Best TWAS P=8.87e-11 · Best GWAS P=1.07e-09 conditioned to 0.811
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | DNAJC11 | 0.03 | 0.03 | lasso | 5 | 0.04 | 3.1e-05 | 5.7 | 5.8 | 5.5e-09 | 0.87 | 0.03 | 0.96 | FALSE |
| 2 | GTEx | Breast Mammary Tissue | GPR153 | 0.13 | 0.03 | lasso | 5 | 0.01 | 1.3e-01 | 6.0 | -6.5 | 8.9e-11 | -0.93 | 0.02 | 0.83 | TRUE |
| 3 | GTEx | Breast Mammary Tissue (Female) | GPR153 | 0.07 | -0.01 | enet | 3 | 0.00 | 4.3e-01 | 6.0 | -5.7 | 1.5e-08 | -0.95 | 0.03 | 0.31 | FALSE |
| 4 | GTEx | Testis | THAP3 | 0.22 | 0.19 | lasso | 5 | 0.22 | 3.1e-10 | 6.0 | 6.3 | 2.4e-10 | 0.94 | 0.01 | 0.99 | FALSE |
| 5 | The Cancer Genome Atlas | Brain Lower Grade Glioma | DNAJC11 | 0.02 | 0.00 | blup | 74 | 0.01 | 9.1e-03 | 6.0 | 5.7 | 1.4e-08 | 0.92 | 0.02 | 0.75 | FALSE |
| 6 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | THAP3 | 0.05 | 0.04 | blup | 51 | 0.05 | 4.4e-06 | -4.7 | 5.2 | 1.6e-07 | 0.51 | 0.50 | 0.44 | FALSE |