TWAS hub - GPR153

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Breast Mammary Tissue	0.135	0.0560	2.8e-03	0.030	NA	-0.002	NA	0.007	1.1e-02	NA	4.5e-01	NA	1.3e-01
2	GTEx	Breast Mammary Tissue (Male)	0.071	0.0679	1.8e-01	-0.012	NA	-0.012	NA	0.000	8.4e-01	NA	7.5e-01	NA	3.1e-01
3	GTEx	Breast Mammary Tissue (Female)	0.073	0.0865	2.3e-01	-0.010	NA	-0.004	NA	-0.008	9.3e-01	NA	4.4e-01	NA	6.8e-01
4	GTEx	Colon Transverse	0.207	0.0660	2.2e-04	0.002	NA	0.033	NA	0.036	2.4e-01	NA	1.1e-02	NA	8.1e-03
5	GTEx	Spleen	0.498	0.0860	2.4e-05	0.485	NA	0.444	NA	0.507	2.9e-14	NA	8.1e-13	NA	4.4e-15
6	METSIM	Adipose	0.033	0.0158	1.0e-02	0.024	0.014	0.018	0.017	0.022	1.2e-04	2.9e-03	7.5e-04	9.7e-04	2.3e-04
7	ROSMAP	Brain Pre-frontal Cortex	0.105	0.0355	1.5e-04	0.046	0.033	0.026	0.044	0.038	1.1e-06	3.5e-05	2.3e-04	2.3e-06	1.1e-05

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Hearing difficulty/problems: Yes	4.8	7.4	14.0	0.9	3.5	0.5	2.9	3.7	3.4	-2.1
Medication: Blood pressure	4.7	8.3	29.8	-5.5	-0.2	-5.2	-0.7	0.2	0.5	0.3
Medication: Omeprazole	4.7	5.6	10.5	0.4	2.5	0.0	-2.5	3.2	3.1	2.6
Medication for cholesterol, blood pressure or diabetes	4.2	7.0	24.8	5.0	0.0	4.8	0.6	-0.5	-0.6	-0.3
Medication: Cholesterol lowering	4.1	6.4	21.6	-4.7	0.0	-4.5	-0.7	0.8	1.1	-0.0
Medication: Simvastatin	3.9	5.7	20.2	-4.2	0.4	-4.5	-0.7	0.8	1.0	0.5
Medication: Gliclazide	3.7	4.1	5.4	-2.2	1.6	-2.3	-1.3	2.1	2.3	2.1
Medication: Omeprazole (e.g. Zanprol)	3.6	4.3	9.8	0.4	2.6	0.0	-1.4	3.1	2.9	1.8
Lung FEV1/FVC ratio	3.4	17.0	49.4	-7.0	-3.1	-6.9	-0.9	-2.5	-2.4	-0.5
High blood pressure (mother)	3.4	4.8	15.4	-3.5	1.0	-3.9	-1.5	0.4	0.4	1.5
Number of live births	3.4	4.9	11.3	-3.2	-2.0	-3.4	0.9	-2.0	-1.9	-0.9
Pulse rate, automated reading	3.3	10.8	34.2	-2.5	-5.8	-2.2	0.2	-3.7	-4.1	0.4
Illnesses of father: None of the above (group 1)	3.3	4.1	10.4	0.4	-2.6	0.9	0.3	-3.2	-3.2	-0.7
Crohns Disease (2012)	3.2	5.2	11.1	0.5	2.7	0.5	3.3	2.2	2.3	-2.7
Had menopause	3.1	3.8	13.2	3.6	0.0	3.6	-0.3	0.4	0.5	-0.2
Illnesses of siblings: Diabetes	3.1	3.8	8.5	-2.9	-1.8	-2.9	-0.4	-1.6	-1.9	0.5
HbA1C	2.9	3.2	7.4	-1.8	0.7	-2.3	-2.7	0.4	0.5	2.3
Comparative body size at age 10	2.9	7.9	27.5	-4.9	-1.5	-5.2	0.3	-0.9	-0.8	-0.8
BMI	2.8	16.0	42.0	-6.5	-3.7	-5.7	-0.2	-3.6	-3.3	-0.4
Ever depressed for a whole week	2.8	3.4	4.7	1.5	2.1	1.6	-1.9	2.1	2.2	1.5
Waist circumference	2.7	9.7	27.7	-5.3	-1.1	-4.8	-2.2	-2.1	-2.0	1.9
Crohns Disease (2017)	2.6	5.7	12.0	0.9	3.0	0.6	3.5	2.0	2.7	-2.5
Heel T-Score	2.6	21.1	70.7	-8.3	-2.1	-8.4	-1.0	-0.9	-1.0	-0.6
Ever unenthusiastic/disinterested for a whole week	2.6	3.2	6.9	1.4	2.6	1.0	0.2	2.4	2.2	-1.4
Diabetes (self-reported)	2.6	4.0	9.7	-2.9	1.1	-3.1	-2.0	0.4	0.5	2.0
Number of children fathered	2.6	2.9	8.1	0.8	2.8	0.7	0.5	2.2	2.5	0.0
Pain all over the body in last month	2.5	2.6	5.6	0.8	-1.0	1.1	2.4	-1.6	-1.4	-2.3
Pulse rate	2.5	4.2	9.3	-0.7	-3.1	-0.5	1.0	-2.6	-3.0	-1.6
Pulse wave Arterial Stiffness index	2.5	3.0	9.4	0.0	-3.1	0.0	-0.8	-2.3	-2.1	1.1
Hearing difficulty/problems with background noise	2.4	3.8	5.8	1.5	2.0	1.4	2.4	2.1	2.3	-1.4
Diabetes diagnosed by doctor	2.4	4.0	8.7	-2.7	1.1	-3.0	-2.4	-0.1	-0.0	2.2
Qualifications: CSEs or equivalent	2.3	3.0	6.4	-1.6	-2.1	-1.3	-0.8	-2.3	-2.5	0.4
High blood pressure	2.3	6.4	22.7	-4.8	0.1	-4.6	-0.8	0.1	0.4	-0.2
Heel bone mineral density (BMD) T-score, automated (right)	2.3	5.2	12.1	-3.1	-2.1	-3.5	1.5	-1.0	-1.0	-2.5
Illnesses of siblings	2.3	3.2	6.9	1.9	-1.0	2.6	2.0	-1.5	-1.5	-1.5
Leg fat percentage (right)	2.3	8.3	29.0	-5.4	-0.7	-5.2	-0.2	-0.9	-0.6	-0.3
Mineral and other dietary supplements	2.3	3.1	8.2	-1.2	-0.3	-1.4	-2.6	-0.9	-1.3	2.9
Leg fat percentage (left)	2.3	8.2	29.7	-5.5	-0.6	-5.1	-0.3	-0.9	-0.5	-0.2
Bipolar Disorder (2018)	2.2	3.6	8.8	0.0	1.5	0.4	3.0	2.2	1.8	-2.4
Body Mass Index (BMI) (2010)	2.2	3.0	8.6	-2.9	-1.5	-2.8	-0.8	-0.9	-0.9	-0.2
Cardiovascular Disease	2.2	7.3	23.2	-4.7	0.9	-4.8	-1.6	0.6	0.8	0.9
Pulse wave peak to peak time	2.2	2.6	8.9	0.2	3.0	0.2	0.5	2.1	2.0	-0.7
Hypertension (Self-reported)	2.2	6.1	21.1	-4.6	0.6	-4.5	-0.7	0.4	0.7	-0.3
Arm fat percentage (left)	2.2	8.7	26.7	-5.2	-2.1	-4.8	-0.3	-1.9	-1.8	-0.3
Arm fat mass (left)	2.2	8.9	25.8	-5.1	-2.1	-4.7	-0.3	-2.3	-2.2	0.0
Medication: Lisinopril	2.2	2.8	7.8	-1.9	-0.1	-1.3	-2.8	-0.6	-0.3	2.5
Neuroticism (2016)	2.1	3.1	5.2	-0.5	1.0	-1.3	-2.0	2.0	2.3	2.3
Heel bone mineral density (BMD) T-score, automated (left)	2.1	4.7	14.4	-3.8	-1.6	-3.8	0.0	-0.5	-0.6	-1.1
Nervous feelings	2.1	4.0	16.6	1.1	0.2	0.7	-4.1	0.6	0.5	3.0
Birth weight	2.1	4.6	10.7	1.0	-2.9	1.4	0.0	-3.2	-3.3	0.5
Leg fat mass (right)	2.1	8.0	27.0	-5.2	-1.1	-4.8	-0.1	-1.6	-1.4	-0.1
Guilty feelings	2.1	3.1	7.3	2.7	2.2	2.1	-0.6	1.4	1.7	-0.3
Leg fat mass (left)	2.1	8.3	28.9	-5.4	-1.0	-4.9	-0.1	-1.6	-1.3	-0.1
Supplements: Zinc	2.0	2.2	6.3	0.8	-0.5	1.0	2.5	-1.2	-1.3	-2.1
Tinnitus: Yes, but not now, but have in the past	2.0	2.1	3.7	1.4	1.4	0.7	-1.2	1.9	1.9	1.3
Body mass index (BMI)	2.0	8.4	26.5	-5.2	-1.7	-4.8	0.1	-1.8	-1.6	-0.4
Type 2 Diabetes (T2D) (2018)	1.9	3.6	8.5	-2.4	0.6	-2.9	-2.3	0.3	0.3	2.2
Medication: Metformin	1.9	2.7	6.7	-2.6	0.6	-2.5	-1.6	-0.3	-0.0	1.7
Arm fat percentage (right)	1.9	7.5	23.1	-4.8	-1.9	-4.5	-0.4	-1.7	-1.5	-0.2
Happiness	1.9	2.3	4.8	0.4	2.2	0.3	-1.4	2.2	2.0	0.5
Arm fat mass (right)	1.9	7.7	22.1	-4.7	-1.9	-4.4	-0.4	-2.2	-2.0	0.2
High blood pressure (siblings)	1.9	2.8	4.4	-1.3	1.7	-2.0	-1.2	2.1	2.1	0.9
Vascular/heart problems diagnosed by doctor	1.9	5.2	18.1	4.3	-0.0	4.2	0.9	0.0	-0.1	-0.0
Depression (Nagel 2018)	1.8	2.6	9.7	3.1	1.3	2.6	-0.4	0.3	0.1	-0.2
Type 2 Diabetes (T2D) (2012)	1.8	2.1	5.8	-2.1	1.1	-2.4	0.8	1.0	1.1	-0.6
Health satisfaction	1.8	2.3	7.5	1.0	2.7	0.6	-1.2	1.7	1.6	0.5
Illnesses of father: Heart disease	1.8	2.6	5.5	-0.6	1.6	-1.2	-1.3	2.3	2.0	1.5
Miserableness	1.8	3.2	4.9	1.2	2.0	0.6	-2.1	1.7	1.9	2.2
Illnesses of father: High blood pressure	1.8	2.2	6.9	-2.5	-0.4	-2.6	1.3	-0.5	-0.6	-0.3
Mean Putamen Volume	1.7	2.0	5.6	1.6	-0.5	1.3	1.9	0.3	0.3	-2.4
Systolic Blood Pressure	1.7	8.5	28.1	-5.1	1.4	-5.3	-0.3	1.0	1.3	-0.8
Diabetes (mother)	1.7	2.1	5.7	-2.4	-0.5	-2.1	-1.1	0.2	0.1	1.8
Multivitamins +/- minerals	1.7	2.1	5.1	2.0	0.3	2.2	1.5	0.6	0.7	-1.7
Whole body fat mass	1.7	6.9	22.0	-4.7	-1.4	-4.3	-0.5	-1.7	-1.5	0.4
Hearing aid user	1.7	2.0	5.5	-2.3	0.2	-2.4	1.1	0.1	0.2	-1.3
Pain type(s) experienced in last month: Hip pain	1.7	2.2	4.5	0.8	1.8	0.2	-1.3	1.6	1.6	2.1
Waist Hip Ratio (WHR)	1.6	7.4	15.8	-2.2	-1.2	-1.7	-3.8	-2.2	-2.6	4.0
Relative age of first facial hair	1.6	3.3	6.6	1.3	2.5	1.3	0.2	2.6	2.6	-0.4
Heart disease (mother)	1.6	2.0	5.9	0.5	1.5	0.1	1.5	1.3	1.3	-2.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.6	1.9	4.2	0.8	1.5	0.4	1.4	2.0	2.0	-0.3
Osteoarthritis (self-reported)	1.6	2.1	3.2	1.4	-1.8	1.4	1.8	-1.4	-1.2	-0.7
Number of self-reported non-cancer illnesses	1.6	2.8	8.2	-2.9	-0.2	-2.5	-1.6	-0.1	-0.3	1.5
Basal cell carcinoma (self-reported)	1.6	1.9	4.9	1.4	-0.4	1.4	-2.0	-0.0	-0.1	2.2
Frequency of depressed mood in last 2 weeks	1.5	2.0	4.4	1.8	2.1	1.4	-1.5	1.2	0.9	0.5
Pack years adult smoking proportion	1.5	2.3	5.5	-0.1	2.0	-0.6	-0.7	2.3	2.3	0.4
Supplements: Glucosamine	1.5	1.9	6.7	-0.1	-0.5	-0.0	2.6	0.6	0.9	-2.3
Medication: Ramipril	1.5	1.9	6.4	-2.5	0.9	-2.5	0.2	0.3	0.2	-0.0
Body fat percentage	1.5	5.9	20.6	-4.5	-1.0	-4.2	-0.4	-1.0	-0.7	-0.1
Number of full sisters	1.5	1.8	3.7	-1.0	-0.9	-1.0	1.9	-1.1	-1.1	-1.9
Ever taken oral contraceptive pill	1.5	1.7	4.1	-1.0	-0.9	-0.9	2.0	-1.1	-0.8	-1.8
Tinnitus: Yes, now most or all of the time	1.5	1.7	5.9	-0.9	0.0	-0.6	2.4	-0.6	-0.5	-2.1
Medication: Blood pressure	1.5	2.9	10.4	-3.2	-0.3	-2.8	-0.9	-0.9	-0.4	0.8
Supplements: Calcium	1.5	1.7	4.6	1.4	0.7	1.4	2.1	0.7	0.9	-1.0
Vitamin and mineral supplements	1.4	1.8	6.2	-2.1	0.4	-2.5	-0.9	0.1	-0.1	1.2
Medication: Atenolol	1.4	1.8	4.8	-2.1	-0.6	-2.2	-0.8	-0.7	-0.8	1.2
Trunk fat mass	1.4	5.9	19.1	-4.4	-1.4	-3.9	-0.7	-1.5	-1.3	0.4
Noisy workplace	1.4	1.7	3.3	1.8	1.7	1.8	0.8	1.0	1.0	-0.5
Medication: Ventolin 100micrograms inhaler	1.4	1.8	4.8	0.5	-1.6	0.3	0.3	-2.1	-2.2	-0.0
Chronic bronchitis/emphysema (mother)	1.4	1.6	4.5	1.3	-0.6	1.3	2.1	0.4	0.9	-1.3
Reason for reducing amount of alcohol drunk: Health precaution	1.4	1.6	3.0	1.4	1.1	1.4	-0.6	1.5	1.7	-0.5
Age at first live birth	1.4	2.5	7.8	-0.0	2.8	-0.1	0.9	2.0	2.0	-0.9
Angina (self-reported)	1.4	1.8	4.3	-2.1	-1.0	-2.0	0.0	-1.2	-1.5	0.2
Age started oral contraceptive pill	1.4	1.8	4.1	-2.0	-1.4	-1.7	0.4	-1.4	-1.1	-0.4
Bipolar Disorder or Schizophrenia	1.3	3.2	7.2	1.7	0.8	2.0	2.7	1.4	1.2	-2.2
Worry (Nagel 2018)	1.3	2.7	8.1	1.5	-0.4	0.8	-2.9	0.7	0.7	2.7
Major Depression (MDD)	1.3	1.6	10.2	0.0	0.1	3.2	1.0	0.0	0.0	0.5
Ever used hormone-replacement therapy (HRT)	1.3	1.6	4.0	1.5	-2.0	1.9	-0.2	-0.8	-0.9	0.3
Fed-up feelings	1.3	2.3	6.0	-0.1	2.4	-0.5	-0.4	2.0	2.1	1.2
Alcohol intake frequency.	1.3	3.0	9.4	-3.1	-0.9	-2.8	-0.7	-1.1	-0.9	0.3
Supplements: Fish oil (including cod liver oil)	1.3	1.7	3.3	1.7	0.1	1.8	1.5	0.4	0.7	-1.6
Medication: Bendroflumethiazide	1.3	2.0	8.2	-2.9	-0.7	-2.2	-0.5	-0.3	0.2	-0.2
Pack years of smoking	1.3	1.9	4.8	-0.0	1.8	-0.4	-0.6	2.2	2.1	0.1
Neuroticism (Nagel 2018)	1.2	2.8	6.2	1.6	0.8	0.9	-2.5	1.1	1.4	2.5
Irritable Bowel Disease (IBD)	1.2	2.9	8.4	0.8	1.7	1.1	2.9	0.7	0.9	-2.4
Triglycerides	1.2	2.0	4.7	-2.2	0.4	-2.1	-1.1	0.9	0.7	1.4
Trunk fat percentage	1.2	4.8	17.3	-4.2	-1.0	-3.8	-0.4	-0.8	-0.6	-0.1
Relative age voice broke	1.2	1.8	6.9	0.3	2.6	0.2	0.1	1.6	1.5	-0.5
Weight	1.2	5.9	14.5	-3.8	-1.9	-3.3	-0.7	-2.4	-2.3	0.9
Alcohol intake versus 10 years previously	1.2	1.8	3.7	1.2	1.5	1.4	-1.9	0.4	0.5	1.6
Medication: Ibuprofen (e.g. Nurofen)	1.2	1.5	2.3	0.4	1.5	0.4	1.4	1.3	1.4	-1.5
High cholesterol (Self-reported)	1.2	2.1	7.5	-2.5	0.2	-2.7	-0.5	0.4	0.6	0.2
Risk taking	1.2	1.8	4.5	2.1	0.7	1.8	1.5	0.5	0.6	-1.1
Hayfever/allergic rhinitis (self-reported)	1.1	1.5	3.9	1.4	0.5	1.1	-1.3	0.7	1.1	2.0
Gout (self-reported)	1.1	1.5	3.3	1.8	0.8	1.8	-0.7	1.1	1.2	0.6
Medication: Amlodipine	1.1	1.6	3.9	-1.9	1.1	-2.0	-1.0	0.7	0.6	0.7
Seen a psychiatrist for nerves, anxiety, tension or depression	1.1	1.4	4.3	2.1	0.9	2.0	-0.5	-0.1	-0.3	0.3
Illness, injury, bereavement, stress in last 2 years	1.1	1.3	2.6	-0.4	-1.6	0.0	1.5	-1.2	-0.9	-1.3
Irritability	1.1	1.8	3.7	0.2	1.9	-0.3	-1.0	1.8	1.8	1.3
Unable to work because of sickness or disability	1.1	1.4	2.7	-1.1	-1.0	-1.0	1.1	-1.6	-1.6	-0.2
Pain experienced in last month	1.1	1.8	5.9	0.1	-1.2	0.2	2.4	-0.8	-0.7	-2.1
Lupus	1.0	1.5	4.4	-1.3	-0.5	-0.8	-1.4	-1.0	-0.7	2.1
Eye problems/disorders: Diabetes related eye disease	1.0	1.1	2.1	1.5	1.4	0.8	-1.3	0.7	0.8	0.7
Angina	1.0	1.3	3.0	-1.7	-0.6	-1.7	0.2	-0.9	-1.4	0.1
Medication: Co-codamol	1.0	1.1	2.2	0.1	1.0	0.1	-1.2	1.5	1.4	1.1
Hip circumference	1.0	4.3	12.9	-3.6	-1.0	-3.3	-0.5	-1.6	-1.4	0.1
Frequency of tiredness / lethargy in last 2 weeks	1.0	1.6	3.2	-0.2	1.8	-0.5	-1.6	1.3	1.3	1.4
Exposure to tobacco smoke at home	1.0	1.1	4.1	-1.3	-0.6	-1.0	-2.0	-0.2	-0.2	0.9
Eye problems/disorders: None of the above	1.0	1.1	4.0	-0.0	0.4	0.3	-2.0	0.4	0.2	1.9
Neck or shoulder pain in last month	1.0	1.4	4.3	-0.6	0.6	-1.1	-2.1	0.4	-0.1	1.8
Friendships satisfaction	1.0	1.3	3.0	1.0	1.4	0.5	-0.9	1.7	1.3	0.5
Asthma (self-reported)	1.0	1.9	4.1	-0.8	-1.3	-0.6	-0.9	-2.0	-1.9	1.5
Wears glasses or contact lenses	1.0	1.1	3.5	1.5	0.2	1.9	0.7	-0.5	-0.9	-0.7
Eye problems/disorders: Glaucoma	1.0	1.1	4.7	-0.6	-0.3	-0.4	2.2	-0.6	-0.5	-1.4
Alzheimer’s Disease (in mother)	0.9	1.0	3.4	0.8	-0.1	0.9	-1.8	-1.0	-1.1	0.6
Alzheimer’s Disease (including proxy)	0.9	1.3	3.7	0.4	-0.8	0.4	-1.0	-1.8	-1.9	0.6
Fasting Glucose	0.9	1.1	1.7	-1.2	-1.3	-0.7	-1.3	-1.0	-0.6	1.1
Systolic blood pressure, automated reading	0.9	2.7	8.8	-2.8	0.6	-3.0	0.1	0.5	0.7	-1.0
Leg fat-free mass (left)	0.9	4.6	9.4	-2.2	-2.4	-1.8	-0.3	-3.0	-3.1	0.6
Maternal smoking around birth	0.9	1.3	2.5	1.6	1.4	1.4	0.8	0.8	1.1	-0.6
Diverticular disease/diverticulitis (self-reported)	0.9	1.0	2.5	-1.1	-0.8	-1.2	-1.0	-0.5	-0.2	1.6
Worrier / anxious feelings	0.9	1.8	6.2	0.7	-0.4	0.3	-2.5	0.4	0.4	2.3
Serious illness, injury or assault of a close relative in last 2 years	0.9	1.0	1.7	-0.5	0.8	-0.5	-1.2	1.3	1.2	1.0
Asthma	0.9	1.8	4.1	-0.7	-1.4	-0.5	-0.8	-2.0	-1.9	1.3
Ever highly irritable/argumentative for 2 days	0.9	1.1	2.3	1.2	1.1	1.2	1.1	0.2	-0.3	-1.5
Exposure to tobacco smoke outside home	0.9	1.2	3.5	-0.7	-0.9	-0.7	-1.1	-1.1	-0.9	1.9
Suffer from ‘nerves’	0.9	1.4	3.5	0.9	-1.4	0.7	-1.9	-0.0	-0.1	1.8
Supplements: Vitamin C	0.9	1.1	2.7	0.6	-1.0	1.0	0.4	-1.7	-1.3	0.8
Ever had bowel cancer screening	0.9	1.0	5.2	-0.8	-0.1	-0.7	-0.7	0.4	0.4	2.3
Breast cancer (self-reported)	0.9	1.1	2.8	1.6	0.5	1.7	-1.0	-0.0	0.1	1.0
Myopia	0.9	1.3	3.6	1.7	0.5	1.9	-0.1	1.2	0.9	-0.1
Heart disease (siblings)	0.9	1.1	3.8	-1.7	-0.4	-2.0	-0.4	0.1	0.1	0.6
Schizophrenia (2018)	0.8	1.7	5.3	2.2	-0.2	2.3	1.1	-0.0	0.1	-0.8
Verbal and Numeric Reasoning (VNR)	0.8	1.9	6.3	-2.5	-0.7	-2.2	-1.2	-0.2	-0.4	-0.2
HDL Cholesterol	0.8	1.4	2.2	1.4	1.0	1.3	1.5	0.6	0.8	-1.3
Schizophrenia (2014)	0.8	1.7	4.2	1.7	-0.2	2.0	1.8	-0.2	-0.2	-1.3
Ulcerative Colitis	0.8	1.1	2.5	0.6	-1.1	1.2	0.5	-1.3	-1.6	-0.6
Chronotype (morning person)	0.8	1.9	5.4	-2.3	-0.7	-2.2	1.1	-0.8	-0.6	-0.8
Frequency of unenthusiasm / disinterest in last 2 weeks	0.8	1.1	2.3	1.5	1.1	1.0	0.7	0.4	0.4	-1.5
Sitting height	0.8	5.8	17.6	3.7	0.0	4.2	-1.5	0.2	-0.1	2.7
Leg predicted mass (left)	0.8	4.3	8.9	-2.1	-2.3	-1.7	-0.3	-2.9	-3.0	0.6
Frequency of tenseness / restlessness in last 2 weeks	0.8	1.3	3.1	1.8	0.1	1.7	-1.1	0.3	0.4	1.2
Had other major operations	0.8	0.9	2.6	1.2	-0.4	1.6	0.1	-0.8	-1.0	-0.6
Financial difficulties in last 2 years	0.8	1.1	3.5	-1.0	0.9	-1.9	0.5	0.9	0.7	-1.0
Depression (self-reported)	0.8	0.9	2.1	-0.5	-0.2	-0.4	-1.5	-1.0	-1.4	1.0
Medication: Lansoprazole	0.8	0.9	3.9	-0.7	0.1	-0.4	2.0	-0.2	0.1	-1.4
Illnesses of mother	0.8	1.0	2.6	1.5	-0.3	1.6	1.2	0.3	0.0	-0.7
Qualifications: O levels/GCSEs or equivalent	0.8	1.2	3.4	-1.8	0.9	-1.8	0.0	0.8	0.8	0.2
Mouth/teeth dental problems: Bleeding gums	0.8	1.1	1.8	-1.1	-1.3	-0.9	-1.2	-0.8	-1.0	0.7
Wheeze or whistling in the chest in last year	0.8	1.4	3.0	-0.2	0.6	-0.1	-1.7	1.4	1.3	1.7
Qualifications: College or University degree	0.8	2.6	6.2	2.1	-0.6	2.5	1.7	-0.2	-0.4	-1.9
Medication: Ibuprofen	0.8	0.9	2.2	0.3	1.0	0.2	1.5	0.8	0.7	-1.4
Knee pain experienced in last month	0.8	1.3	3.1	-0.1	0.2	-0.5	1.0	1.7	1.4	-1.8
Forced expiratory volume in 1-second (FEV1), predicted	0.8	1.7	6.0	-0.1	-0.9	-0.1	-1.6	-1.2	-1.1	2.5
Commuting to job workplace: Walk	0.8	0.8	2.9	1.4	1.0	1.7	-0.1	0.2	-0.1	0.3
Number of operations (self-reported)	0.8	1.1	3.6	-0.5	-0.9	-0.2	0.5	-1.7	-1.9	-0.2
Cholesterol lowering medication	0.8	1.2	3.8	-1.6	1.0	-1.9	-0.3	0.8	0.7	0.5
Intelligence (Savage-Jansen 2018)	0.7	2.2	4.8	-1.9	-1.6	-1.7	-2.2	-0.8	-0.9	0.4
Age at First Birth	0.7	1.0	3.0	1.1	-0.4	1.5	-1.7	-0.1	-0.2	0.7
Primary Biliary Cirrhosis	0.7	0.9	1.8	-0.6	0.7	-0.4	-1.3	1.0	1.0	1.4
Diabetes (father)	0.7	0.8	2.5	-0.1	0.2	-0.5	-1.5	0.7	0.7	1.6
Taking other prescription medications	0.7	1.1	3.2	-1.2	0.2	-0.8	-1.4	0.5	0.5	1.8
Hair/balding pattern: Pattern 2	0.7	0.8	3.4	0.3	-0.2	0.6	1.8	-0.0	0.1	-1.4
Neuroticism score	0.7	1.5	2.7	0.8	1.3	0.5	-1.5	1.2	1.4	1.6
Headache pain in last month	0.7	1.1	4.2	-0.1	1.0	0.1	-1.6	-0.2	-0.0	2.0
Shortness of breath walking on level ground	0.7	0.8	1.4	-0.9	0.9	-1.0	0.5	1.1	1.2	0.1
Overall health rating	0.7	1.6	6.2	-2.5	0.7	-1.9	-0.5	0.1	0.3	0.4
Chest pain or discomfort	0.7	1.0	2.4	-1.6	-1.0	-1.2	0.4	-0.8	-1.1	-0.1
Commuting to job workplace: Car/motor vehicle	0.7	0.8	2.1	0.8	0.2	0.4	-1.5	0.6	0.8	1.2
Handedness (chirality/laterality): Left-handed	0.7	0.9	2.7	0.0	1.6	0.3	0.1	1.3	1.4	-0.2
Long-standing illness, disability or infirmity	0.7	1.0	2.8	-1.7	0.0	-1.1	-0.4	-1.0	-1.2	0.6
Leg predicted mass (right)	0.7	3.5	7.1	-1.9	-2.2	-1.4	-0.3	-2.6	-2.7	0.7
Mother’s age at death	0.7	0.9	1.9	1.4	0.3	1.0	-0.8	0.7	0.8	1.2
Financial situation satisfaction	0.7	0.8	2.4	0.3	0.9	-0.1	-1.6	-0.2	-0.1	1.5
Commuting to job workplace: Public transport	0.7	0.9	3.1	-0.7	-0.4	-0.3	0.9	-0.8	-0.9	-1.8
Alcohol drinker status: Never	0.7	0.8	2.1	-1.4	-0.1	-0.9	1.3	-0.3	-0.1	-1.1
Basal metabolic rate	0.7	4.0	7.0	-2.3	-1.9	-1.9	-0.5	-2.6	-2.6	1.1
Diastolic blood pressure, automated reading	0.7	2.2	3.2	-1.4	-1.3	-1.4	1.7	-1.5	-1.1	-1.8
Deep venous thrombosis (DVT) (self-reported)	0.7	0.9	2.2	0.5	1.1	0.5	0.2	1.5	1.4	-0.5
Alcohol drinker status: Previous	0.7	0.8	1.9	-0.8	-1.1	-0.7	0.8	-0.6	-0.8	-1.4
Alzheimer’s Disease (in father)	0.6	0.7	1.7	0.2	-1.2	-0.1	0.0	-1.2	-1.3	0.2
Prostate Cancer	0.6	0.9	2.1	1.1	-1.4	1.3	-0.3	-0.5	-0.8	-0.4
Rheumatoid Arthritis	0.6	0.8	1.6	-1.0	1.3	-0.6	0.2	1.2	1.0	-0.2
Blood Platelet Count	0.6	7.2	11.0	-2.5	-3.1	-2.2	-3.3	-2.8	-2.3	2.5
Respiratory disease	0.6	1.4	3.8	0.1	-1.1	0.4	-0.6	-1.9	-1.9	0.9
Average weekly spirits intake	0.6	0.7	2.5	1.0	0.1	1.1	-0.6	0.0	0.2	1.6
Average weekly fortified wine intake	0.6	0.7	1.6	-0.5	-0.7	-1.1	-1.3	-0.8	-0.6	0.5
Bilateral oophorectomy (both ovaries removed)	0.6	0.7	1.0	-0.8	-0.9	-0.8	-0.9	-0.7	-0.6	1.0
Stomach or abdominal pain in last month	0.6	0.7	2.7	-0.1	0.6	-0.3	-1.3	0.4	0.4	1.6
Impedance of leg (left)	0.6	2.8	6.7	0.9	2.3	1.0	-0.5	2.3	2.6	0.6
Number of incorrect matches in round	0.6	1.0	3.0	1.7	-0.0	1.6	-0.6	0.7	0.9	-0.3
Fluid intelligence score	0.6	1.3	3.4	-1.9	-0.8	-1.8	0.4	-0.3	-0.4	-1.1
Trunk fat-free mass	0.6	3.3	7.3	-1.3	-1.8	-0.8	-0.7	-2.7	-2.7	1.5
Time employed in main current job	0.6	0.7	1.9	-0.3	0.4	-0.4	-1.4	0.8	1.0	0.8
Prospective memory result	0.6	0.7	1.2	1.1	-0.0	0.7	1.0	-0.9	-1.0	-0.3
Lung cancer (father)	0.6	0.8	1.8	0.2	-0.8	0.2	-1.2	-0.9	-0.7	1.4
Length of working week for main job	0.6	0.7	2.0	0.1	-1.4	0.1	0.8	-1.0	-0.9	-0.4
Breastfed as a baby	0.6	0.7	2.7	-0.3	-0.2	-0.3	1.6	-0.6	-0.7	-1.1
Medication: Paracetamol	0.6	0.9	2.3	1.2	0.6	1.1	1.5	-0.1	-0.1	-1.0
Family relationship satisfaction	0.6	0.7	2.4	0.7	1.5	0.7	0.8	0.7	0.0	-0.7
Whole body fat-free mass	0.6	3.6	7.6	-1.7	-2.0	-1.3	-0.4	-2.8	-2.8	1.1
Leg fat-free mass (right)	0.6	3.4	7.0	-1.8	-2.2	-1.3	-0.3	-2.6	-2.6	0.7
Mood swings	0.6	1.1	2.3	1.0	0.9	0.7	-1.1	0.9	1.0	1.5
Whole body water mass	0.6	3.3	6.7	-1.7	-1.9	-1.3	-0.5	-2.6	-2.6	1.2
Arm fat-free mass (left)	0.6	2.8	5.5	-2.3	-1.3	-1.9	-0.0	-2.0	-1.9	1.0
Commuting to job workplace: Cycle	0.6	0.7	2.1	-0.5	0.1	-0.4	1.2	-0.6	-0.8	-1.5
Arm predicted mass (left)	0.6	2.8	5.2	-2.3	-1.3	-1.8	-0.5	-2.0	-1.9	1.3
Depressed Affect (Nagel 2018)	0.5	0.9	2.1	0.6	0.9	0.5	-1.3	0.7	1.0	1.4
Ulcerative Colitis (UC)	0.5	1.0	1.7	0.6	-0.5	1.1	1.3	-0.9	-1.2	-1.2
Breast Cancer	0.5	1.2	3.2	-0.9	-0.3	-0.4	-1.8	-1.0	-0.8	1.6
Lung FVC	0.5	2.8	5.6	1.2	2.0	0.6	0.9	2.2	2.4	-1.4
Neuroticism	0.5	1.1	2.2	1.1	0.9	0.8	-0.9	0.9	1.1	1.5
Sensitivity / hurt feelings	0.5	0.9	3.5	1.0	0.2	0.7	-1.9	0.1	0.2	1.1
Medication for hormone replacement therapy	0.5	0.5	2.2	0.8	-0.8	1.5	0.0	-0.1	-0.2	0.5
Qualifications: None of the above	0.5	1.1	3.6	-1.8	0.3	-1.9	-0.3	-0.1	0.0	1.0
Heart attack	0.5	0.7	1.8	-1.3	-0.2	-1.3	-0.5	-0.4	-0.8	0.3
Father’s age at death	0.5	0.7	2.6	1.5	-0.3	1.6	-0.0	-0.0	-0.2	-0.1
Trunk predicted mass	0.5	3.0	7.0	-1.2	-1.6	-0.7	-0.5	-2.6	-2.6	1.5
Blood clot in the leg (DVT)	0.5	0.7	1.4	0.6	1.0	0.6	0.1	1.2	1.1	-0.6
Forced vital capacity (FVC), Best measure	0.5	1.9	6.0	2.4	0.3	2.4	-0.7	-0.3	-0.2	0.9
Arm fat-free mass (right)	0.5	2.4	4.3	-1.8	-1.3	-1.4	-0.4	-2.1	-2.0	1.2
Number of full brothers	0.5	0.7	2.3	-1.2	0.1	-1.5	0.8	0.1	0.6	-0.3
Emphysema/chronic bronchitis	0.5	0.5	0.9	-1.0	-0.4	-0.7	-0.2	-0.7	-0.9	0.9
Arm predicted mass (right)	0.5	2.8	4.9	-2.1	-1.4	-1.6	-0.3	-2.2	-2.1	1.1
Age at last live birth	0.5	0.8	1.8	-1.3	0.4	-1.2	0.8	0.6	0.6	-0.8
Average weekly red wine intake	0.5	0.7	2.1	0.6	-0.5	1.1	1.1	0.2	0.2	-1.5
Qualifications: nursing, teaching	0.5	0.8	1.4	0.5	-0.5	0.7	1.1	-1.2	-1.2	-0.9
Osteoporosis (self-reported)	0.5	0.7	3.2	-0.1	-0.8	0.1	-1.8	-0.4	-0.2	0.8
Average weekly champagne plus white wine intake	0.5	0.6	1.8	1.1	0.5	1.3	0.4	0.2	0.0	-1.0
Medication: Paracetamol	0.5	0.8	2.3	0.8	-0.2	0.9	1.5	-0.5	-0.7	-0.9
Schizophrenia vs Biploar Disorder	0.4	0.6	3.2	0.0	0.6	1.8	-0.4	0.0	0.0	0.6
LDL Cholesterol	0.4	0.7	2.2	-0.2	-1.0	-0.4	-1.1	-0.2	-0.2	1.5
Height	0.4	7.9	15.2	3.9	-0.7	3.9	-2.6	-1.5	-1.5	3.7
Smoking Status	0.4	1.0	2.7	1.0	1.7	1.4	1.1	0.4	0.3	-0.3
Number of treatments/medications taken	0.4	0.7	3.2	-1.8	0.1	-1.0	-0.4	0.2	0.4	0.6
Other serious medical condition/disability diagnosed by doctor	0.4	0.6	2.0	-0.0	0.2	0.4	1.3	-0.2	-0.4	-1.4
Severe depression (siblings)	0.4	0.5	1.2	0.9	-0.0	1.1	-0.9	0.4	0.4	0.3
Impedance of leg (right)	0.4	1.8	3.9	0.9	2.0	0.8	-0.3	1.8	2.0	0.4
Townsend deprivation index at recruitment	0.4	0.6	1.7	0.3	-0.2	0.6	0.5	-1.3	-1.3	-0.2
Chronic bronchitis/emphysema (father)	0.4	0.5	1.4	0.5	0.3	0.7	0.2	1.0	1.2	0.6
Forced vital capacity (FVC)	0.4	1.4	4.6	2.1	0.7	2.0	-0.4	0.3	0.4	0.8
Hair/balding pattern: Pattern 3	0.4	0.6	1.9	0.2	-0.1	0.7	-1.2	-0.2	0.1	1.4
Standing height	0.4	3.9	6.9	2.2	-1.0	2.6	-1.3	-1.8	-1.9	2.5
Tense / ‘highly strung’	0.4	0.7	1.3	0.7	0.6	0.7	-1.0	1.0	0.7	1.2
Peak expiratory flow (PEF)	0.4	0.9	1.7	-1.1	-1.3	-1.0	-0.2	-1.2	-1.0	0.1
Loud music exposure frequency	0.4	0.4	1.1	0.9	0.1	1.0	0.8	-0.4	-0.5	-0.3
Glaucoma (self-reported)	0.4	0.4	1.8	-0.2	0.4	-0.0	1.4	0.2	0.4	-1.0
Worry too long after embarrassment	0.4	0.7	1.8	0.5	1.2	0.1	-0.2	1.1	1.3	0.2
Medication: Allopurinol	0.4	0.5	1.5	1.2	0.4	1.2	-0.1	0.6	0.6	0.1
Medication: Seretide 50 evohaler	0.4	0.5	1.0	-1.0	-0.9	-0.9	-0.3	-0.1	0.1	1.0
Medication for cholesterol	0.4	0.6	1.9	1.4	0.2	1.2	0.2	0.5	0.3	-0.5
Back pain experienced in last month	0.4	0.6	1.5	0.9	0.8	0.8	-1.2	0.2	-0.1	0.8
Medication: Aspirin	0.4	0.6	1.3	-1.1	-0.9	-0.7	0.3	-0.7	-0.8	-0.5
Heart attack/myocardial infarction (self-reported)	0.4	0.6	1.4	-1.1	-0.1	-1.2	-0.7	-0.2	-0.7	0.5
Impedance of whole body	0.4	1.8	2.9	1.6	1.3	1.6	-0.3	1.6	1.7	0.1
Coronary Artery Disease (CAD)	0.3	0.3	0.8	0.2	0.8	0.2	0.1	0.9	0.8	-0.3
Hand grip strength (left)	0.3	0.9	2.2	1.5	-0.2	1.4	1.0	0.3	0.0	-0.9
Current tobacco smoking	0.3	0.5	0.9	-0.1	0.9	-0.3	0.8	0.7	0.6	-1.0
Hayfever, allergic rhinitis or eczema	0.3	0.7	1.7	-0.1	-1.3	-0.0	-0.9	-0.7	-0.5	1.1
Past tobacco smoking	0.3	0.6	1.8	-1.0	-0.4	-1.4	-0.6	0.1	0.4	-0.7
Mouth/teeth dental problems	0.3	0.5	1.6	1.3	0.3	0.8	0.1	0.4	0.7	-0.2
Allergy	0.3	0.8	2.8	0.0	0.6	-0.1	1.0	0.8	0.7	-1.7
Impedance of arm (right)	0.3	1.4	4.2	2.0	0.2	2.0	-0.5	0.8	0.7	-0.1
Falls in the last year	0.3	0.4	1.0	1.0	0.5	1.0	0.4	-0.1	0.3	-0.2
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.5	0.9	0.4	0.9	0.3	-0.6	0.9	0.8	0.7
Hair/balding pattern: Pattern 4	0.3	0.8	2.2	-0.9	1.3	-1.5	-0.1	0.8	0.5	-0.4
Mouth/teeth dental problems: Loose teeth	0.3	0.4	1.0	0.4	-0.9	0.1	0.1	-0.9	-1.0	0.1
Medication for pain relief, constipation, heartburn	0.3	0.5	1.1	0.4	-1.0	0.3	-0.7	-0.8	-1.1	0.0
Migraine (self-reported)	0.3	0.4	0.9	0.3	0.8	0.3	0.9	0.0	-0.0	-1.0
Mean time to correctly identify matches	0.3	0.5	1.5	0.0	0.8	-0.1	-0.0	1.1	1.2	0.4
Had major operations	0.3	0.4	0.7	0.5	-0.5	0.7	0.4	-0.9	-0.8	-0.2
Leg pain on walking	0.3	0.4	0.7	0.6	0.8	0.4	0.8	0.6	0.8	0.1
Smoking status: Previous	0.3	0.5	1.5	0.8	0.5	1.2	0.9	-0.2	-0.3	0.5
Loneliness, isolation	0.3	0.4	1.4	-0.4	0.2	-0.4	-1.0	-0.1	0.2	1.2
Ever had stillbirth, spontaneous miscarriage or termination	0.3	0.3	0.8	-0.2	0.7	0.0	0.5	0.5	0.5	0.9
Eye problems/disorders: Cataract	0.3	0.4	1.3	-0.9	-0.7	-1.1	0.1	-0.1	0.1	-0.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.4	1.9	-0.4	-1.4	-0.4	0.2	-0.2	-0.2	-0.7
Smoking status: Current	0.3	0.4	0.7	0.0	0.8	-0.1	0.8	0.8	0.8	-0.7
Average weekly beer plus cider intake	0.3	0.5	1.5	1.2	0.5	1.0	0.7	0.2	0.0	-0.1
Ever had prostate specific antigen (PSA) test	0.3	0.4	1.0	-0.5	0.3	-0.4	-1.0	0.1	0.1	1.0
Reaction Time	0.2	0.4	1.2	0.4	0.7	0.3	0.2	0.8	1.1	0.5
Blood Eosinophil Count	0.2	1.3	4.5	-0.5	-0.3	-0.8	-2.1	-0.3	-0.1	1.9
Blood Red Count	0.2	1.8	7.0	2.2	0.6	2.6	0.8	0.2	0.0	-0.1
Allergy or Eczema	0.2	0.4	0.8	0.7	-0.3	0.8	-0.2	0.7	0.9	0.8
Tanning	0.2	2.9	9.5	-0.2	1.1	0.2	3.1	1.2	1.0	-2.6
Serious illness, injury or assault to yourself	0.2	0.3	0.9	-0.3	0.6	-0.1	-0.0	-0.6	-0.9	-0.2
Medication: Levothyroxine sodium	0.2	0.3	0.7	0.5	-0.5	0.7	-0.2	-0.3	-0.5	0.9
Qualifications: A levels/AS levels or equivalent	0.2	0.4	1.2	-0.1	0.9	-0.0	0.8	0.2	-0.0	-1.1
Mouth/teeth dental problems: Dentures	0.2	0.3	0.6	-0.6	0.8	-0.2	0.7	-0.2	-0.5	-0.2
Impedance of arm (left)	0.2	0.8	2.6	1.6	0.0	1.6	-0.5	0.6	0.5	-0.0
Birth weight of first child	0.2	0.4	1.0	0.6	-0.4	0.8	-0.2	-0.7	-1.0	0.5
Hypothyroidism/myxoedema (self-reported)	0.2	0.3	0.6	0.8	-0.7	0.7	0.6	-0.2	-0.2	0.2
Qualifications: NVQ or HND or HNC or equivalent	0.2	0.2	0.6	0.8	0.3	0.5	-0.4	0.4	0.1	0.2
Medication: Aspirin	0.2	0.2	0.7	-0.8	-0.5	-0.2	0.1	-0.5	-0.5	-0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.4	2.1	-0.2	-0.5	-0.1	-1.5	-0.6	-0.5	-0.3
Medication: Atorvastatin	0.2	0.2	0.5	-0.5	-0.5	-0.4	-0.7	-0.4	-0.5	0.1
Ever smoked	0.2	0.4	1.2	0.9	-0.2	1.1	0.2	-0.4	-0.7	0.6
Fractured/broken bones in last 5 years	0.2	0.2	0.5	0.7	0.6	0.6	0.2	0.1	0.4	0.1
Ovarian Cancer	0.1	0.1	0.3	0.4	0.1	0.3	-0.3	0.1	0.5	-0.5
Blood White Count	0.1	0.9	1.8	-0.9	0.5	-1.0	-1.3	0.9	1.1	0.7
Hypothyroidism (self reported)	0.1	0.2	0.7	0.2	-0.7	-0.0	0.9	-0.1	-0.1	-0.1
Hair Pigment	0.1	2.5	4.2	2.0	1.5	1.8	-0.0	1.9	2.0	0.3
Ever had hysterectomy (womb removed)	0.1	0.2	0.5	0.3	0.3	0.7	0.3	0.0	0.2	-0.5
Hand grip strength (right)	0.1	0.2	0.3	0.5	-0.5	0.6	0.5	-0.3	-0.4	-0.4
Age when periods started (menarche)	0.1	0.1	0.7	0.1	0.2	0.4	0.1	-0.1	-0.1	0.9
Alcohol usually taken with meals	0.1	0.2	0.9	-0.3	-0.9	0.1	-0.3	-0.0	0.1	-0.2
Forced expiratory volume in 1-second (FEV1)	0.1	0.2	0.7	-0.2	-0.6	-0.2	0.1	-0.9	-0.6	0.2
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.4	1.0	0.4	-0.6	0.5	-0.4	-1.0	-0.9	0.7
Pulse wave reflection index	0.1	0.1	0.5	-0.3	-0.7	-0.6	0.1	-0.2	0.0	0.3
Comparative height size at age 10	0.1	0.8	1.4	-0.0	-0.8	0.4	-1.0	-1.2	-1.1	1.2
Mouth/teeth dental problems: Mouth ulcers	0.1	0.1	0.6	0.0	-0.3	-0.1	-0.5	-0.0	0.2	0.8
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.0	0.0	0.1	0.1	-0.1	-0.2	-0.0	0.3	0.2	-0.3

Hub : Genes

GPR153

Models

Trait associations