[Hub]/) : Traits : BMI :

chr1:10,391,536-12,731,572

Best TWAS P=1.96e-11 · Best GWAS P=1.6e-11 conditioned to 1

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex EXOSC10 0.06 0.08 lasso 2 0.07 6.8e-09 6.0 6.0 2.0e-09 0.93 0.22 0.78 FALSE
2 CommonMind Brain Pre-frontal Cortex MTOR 0.13 0.15 lasso 4 0.15 5.6e-18 5.5 5.9 4.1e-09 0.88 0.43 0.57 FALSE
3 GTEx Adipose Subcutaneous MASP2 0.10 0.06 lasso 2 0.03 8.8e-04 5.5 5.5 4.5e-08 0.73 0.31 0.56 FALSE
4 GTEx Adipose Visceral Omentum RP4-635E18.7 0.19 0.08 lasso 6 0.05 9.0e-04 6.0 5.5 4.0e-08 0.90 0.06 0.86 FALSE
5 GTEx Artery Tibial EXOSC10 0.09 0.02 lasso 5 0.01 6.6e-02 5.9 -5.3 9.9e-08 0.13 0.09 0.35 TRUE
6 GTEx Brain Cerebellar Hemisphere EXOSC10 0.23 0.10 lasso 3 0.12 6.4e-04 6.1 6.6 3.5e-11 0.96 0.02 0.90 FALSE
7 GTEx Brain Cerebellum EXOSC10 0.33 0.16 lasso 6 0.18 3.8e-06 5.6 6.2 4.2e-10 0.93 0.05 0.94 FALSE
8 GTEx Brain Cerebellum RP4-635E18.7 0.17 0.17 lasso 5 0.09 1.3e-03 5.6 5.9 4.5e-09 0.91 0.06 0.86 FALSE
9 GTEx Brain Cortex RP4-635E18.7 0.17 0.05 lasso 4 0.07 6.4e-03 5.6 5.8 6.2e-09 0.89 0.08 0.55 FALSE
10 GTEx Lung EXOSC10 0.11 0.07 lasso 4 0.05 1.2e-04 5.6 5.7 1.1e-08 0.90 0.60 0.32 FALSE
11 GTEx Nerve Tibial MASP2 0.14 0.07 lasso 5 0.09 1.2e-06 5.5 5.3 1.1e-07 0.68 0.68 0.15 FALSE
12 GTEx Skin Not Sun Exposed Suprapubic CLCN6 0.12 0.03 lasso 3 0.04 3.3e-03 5.5 5.5 3.4e-08 0.12 0.00 0.98 FALSE
13 GTEx Thyroid RP4-635E18.7 0.07 0.02 lasso 2 0.01 5.5e-02 5.6 6.2 7.8e-10 0.87 0.11 0.41 FALSE
14 METSIM Adipose MTOR 0.04 0.02 bslmm 434 0.02 1.5e-04 5.5 6.0 1.9e-09 0.85 0.28 0.69 FALSE
15 ROSMAP Brain Pre-frontal Cortex PLOD1 0.11 0.03 blup 459 0.05 1.3e-07 3.8 5.4 6.1e-08 0.10 0.26 0.69 FALSE
16 ROSMAP Brain Pre-frontal Cortex EXOSC10 0.06 0.06 lasso 2 0.06 4.9e-08 6.0 6.0 1.6e-09 0.93 0.19 0.81 FALSE
17 ROSMAP Brain Pre-frontal Cortex MTOR 0.07 0.05 bslmm 423 0.04 2.0e-06 5.5 6.4 1.3e-10 0.88 0.21 0.79 FALSE
18 The Cancer Genome Atlas Colon Adenocarcinoma CLCN6 0.14 0.05 blup 104 0.09 1.2e-05 4.1 5.6 2.6e-08 0.14 0.07 0.89 TRUE
19 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma MTOR 0.02 0.02 blup 54 0.02 5.4e-03 6.7 6.7 2.0e-11 0.98 0.02 0.91 TRUE
20 The Cancer Genome Atlas Brain Lower Grade Glioma MTOR 0.03 0.01 blup 54 0.02 5.9e-03 6.7 6.4 1.3e-10 0.93 0.03 0.72 FALSE
21 The Cancer Genome Atlas Liver Hepatocellular Carcinoma MASP2 0.05 0.03 blup 30 0.04 6.0e-03 3.6 -5.3 1.0e-07 -0.80 0.02 0.62 FALSE