Best TWAS P=1.96e-11 · Best GWAS P=1.6e-11 conditioned to 1
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | EXOSC10 | 0.06 | 0.08 | lasso | 2 | 0.07 | 6.8e-09 | 6.0 | 6.0 | 2.0e-09 | 0.93 | 0.22 | 0.78 | FALSE |
2 | CommonMind | Brain Pre-frontal Cortex | MTOR | 0.13 | 0.15 | lasso | 4 | 0.15 | 5.6e-18 | 5.5 | 5.9 | 4.1e-09 | 0.88 | 0.43 | 0.57 | FALSE |
3 | GTEx | Adipose Subcutaneous | MASP2 | 0.10 | 0.06 | lasso | 2 | 0.03 | 8.8e-04 | 5.5 | 5.5 | 4.5e-08 | 0.73 | 0.31 | 0.56 | FALSE |
4 | GTEx | Adipose Visceral Omentum | RP4-635E18.7 | 0.19 | 0.08 | lasso | 6 | 0.05 | 9.0e-04 | 6.0 | 5.5 | 4.0e-08 | 0.90 | 0.06 | 0.86 | FALSE |
5 | GTEx | Artery Tibial | EXOSC10 | 0.09 | 0.02 | lasso | 5 | 0.01 | 6.6e-02 | 5.9 | -5.3 | 9.9e-08 | 0.13 | 0.09 | 0.35 | TRUE |
6 | GTEx | Brain Cerebellar Hemisphere | EXOSC10 | 0.23 | 0.10 | lasso | 3 | 0.12 | 6.4e-04 | 6.1 | 6.6 | 3.5e-11 | 0.96 | 0.02 | 0.90 | FALSE |
7 | GTEx | Brain Cerebellum | EXOSC10 | 0.33 | 0.16 | lasso | 6 | 0.18 | 3.8e-06 | 5.6 | 6.2 | 4.2e-10 | 0.93 | 0.05 | 0.94 | FALSE |
8 | GTEx | Brain Cerebellum | RP4-635E18.7 | 0.17 | 0.17 | lasso | 5 | 0.09 | 1.3e-03 | 5.6 | 5.9 | 4.5e-09 | 0.91 | 0.06 | 0.86 | FALSE |
9 | GTEx | Brain Cortex | RP4-635E18.7 | 0.17 | 0.05 | lasso | 4 | 0.07 | 6.4e-03 | 5.6 | 5.8 | 6.2e-09 | 0.89 | 0.08 | 0.55 | FALSE |
10 | GTEx | Lung | EXOSC10 | 0.11 | 0.07 | lasso | 4 | 0.05 | 1.2e-04 | 5.6 | 5.7 | 1.1e-08 | 0.90 | 0.60 | 0.32 | FALSE |
11 | GTEx | Nerve Tibial | MASP2 | 0.14 | 0.07 | lasso | 5 | 0.09 | 1.2e-06 | 5.5 | 5.3 | 1.1e-07 | 0.68 | 0.68 | 0.15 | FALSE |
12 | GTEx | Skin Not Sun Exposed Suprapubic | CLCN6 | 0.12 | 0.03 | lasso | 3 | 0.04 | 3.3e-03 | 5.5 | 5.5 | 3.4e-08 | 0.12 | 0.00 | 0.98 | FALSE |
13 | GTEx | Thyroid | RP4-635E18.7 | 0.07 | 0.02 | lasso | 2 | 0.01 | 5.5e-02 | 5.6 | 6.2 | 7.8e-10 | 0.87 | 0.11 | 0.41 | FALSE |
14 | METSIM | Adipose | MTOR | 0.04 | 0.02 | bslmm | 434 | 0.02 | 1.5e-04 | 5.5 | 6.0 | 1.9e-09 | 0.85 | 0.28 | 0.69 | FALSE |
15 | ROSMAP | Brain Pre-frontal Cortex | PLOD1 | 0.11 | 0.03 | blup | 459 | 0.05 | 1.3e-07 | 3.8 | 5.4 | 6.1e-08 | 0.10 | 0.26 | 0.69 | FALSE |
16 | ROSMAP | Brain Pre-frontal Cortex | EXOSC10 | 0.06 | 0.06 | lasso | 2 | 0.06 | 4.9e-08 | 6.0 | 6.0 | 1.6e-09 | 0.93 | 0.19 | 0.81 | FALSE |
17 | ROSMAP | Brain Pre-frontal Cortex | MTOR | 0.07 | 0.05 | bslmm | 423 | 0.04 | 2.0e-06 | 5.5 | 6.4 | 1.3e-10 | 0.88 | 0.21 | 0.79 | FALSE |
18 | The Cancer Genome Atlas | Colon Adenocarcinoma | CLCN6 | 0.14 | 0.05 | blup | 104 | 0.09 | 1.2e-05 | 4.1 | 5.6 | 2.6e-08 | 0.14 | 0.07 | 0.89 | TRUE |
19 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | MTOR | 0.02 | 0.02 | blup | 54 | 0.02 | 5.4e-03 | 6.7 | 6.7 | 2.0e-11 | 0.98 | 0.02 | 0.91 | TRUE |
20 | The Cancer Genome Atlas | Brain Lower Grade Glioma | MTOR | 0.03 | 0.01 | blup | 54 | 0.02 | 5.9e-03 | 6.7 | 6.4 | 1.3e-10 | 0.93 | 0.03 | 0.72 | FALSE |
21 | The Cancer Genome Atlas | Liver Hepatocellular Carcinoma | MASP2 | 0.05 | 0.03 | blup | 30 | 0.04 | 6.0e-03 | 3.6 | -5.3 | 1.0e-07 | -0.80 | 0.02 | 0.62 | FALSE |