Best TWAS P=5.58e-13 · Best GWAS P=5.89e-22 conditioned to 3.14e-12
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | SRR | 0.27 | 0.48 | lasso | 1 | 0.48 | 3.5e-65 | -6.1 | 6.1 | 1.2e-09 | -0.03 | 1.00 | 0.00 | FALSE |
| 2 | GTEx | Adipose Subcutaneous | SRR | 0.16 | 0.16 | lasso | 9 | 0.18 | 1.9e-14 | -6.4 | 7.2 | 5.6e-13 | -0.07 | 1.00 | 0.00 | TRUE |
| 3 | GTEx | Adipose Visceral Omentum | SRR | 0.29 | 0.26 | lasso | 5 | 0.25 | 1.8e-13 | -6.1 | 6.4 | 2.0e-10 | -0.05 | 1.00 | 0.00 | FALSE |
| 4 | GTEx | Adrenal Gland | SRR | 0.38 | 0.37 | lasso | 6 | 0.38 | 8.1e-15 | -6.1 | 7.0 | 2.7e-12 | -0.06 | 1.00 | 0.00 | FALSE |
| 5 | GTEx | Artery Aorta | SRR | 0.33 | 0.33 | lasso | 2 | 0.32 | 6.1e-18 | -6.1 | 6.2 | 7.3e-10 | -0.03 | 1.00 | 0.00 | FALSE |
| 6 | GTEx | Artery Coronary | SRR | 0.44 | 0.28 | lasso | 8 | 0.26 | 2.5e-09 | -6.4 | 6.0 | 1.6e-09 | -0.06 | 0.99 | 0.00 | FALSE |
| 7 | GTEx | Artery Tibial | SRR | 0.22 | 0.23 | lasso | 4 | 0.24 | 3.9e-19 | -6.4 | 6.1 | 8.7e-10 | -0.06 | 1.00 | 0.00 | FALSE |
| 8 | GTEx | Brain Cerebellar Hemisphere | SRR | 0.37 | 0.24 | lasso | 7 | 0.22 | 2.1e-06 | -6.1 | 5.7 | 1.2e-08 | -0.02 | 0.62 | 0.02 | FALSE |
| 9 | GTEx | Brain Cerebellum | SRR | 0.26 | 0.20 | lasso | 3 | 0.21 | 8.7e-07 | -6.1 | 6.6 | 3.8e-11 | -0.03 | 0.39 | 0.04 | FALSE |
| 10 | GTEx | Brain Frontal Cortex BA9 | SRR | 0.25 | 0.24 | lasso | 3 | 0.21 | 3.5e-06 | -6.1 | 6.2 | 5.7e-10 | -0.03 | 0.27 | 0.07 | FALSE |
| 11 | GTEx | Breast Mammary Tissue | SRR | 0.20 | 0.21 | lasso | 3 | 0.20 | 8.2e-11 | -6.3 | 6.2 | 4.7e-10 | -0.07 | 1.00 | 0.00 | FALSE |
| 12 | GTEx | Breast Mammary Tissue (Female) | SRR | 0.24 | 0.25 | lasso | 3 | 0.21 | 6.3e-07 | -6.3 | 6.4 | 1.2e-10 | -0.07 | 0.78 | 0.02 | FALSE |
| 13 | GTEx | Cells EBV-transformed lymphocytes | SRR | 0.39 | 0.34 | lasso | 5 | 0.35 | 3.1e-12 | -6.1 | 6.5 | 9.8e-11 | -0.04 | 1.00 | 0.00 | FALSE |
| 14 | GTEx | Cells Transformed fibroblasts | SRR | 0.36 | 0.38 | lasso | 4 | 0.38 | 8.2e-30 | -6.1 | 6.2 | 4.8e-10 | -0.03 | 1.00 | 0.00 | FALSE |
| 15 | GTEx | Colon Sigmoid | SRR | 0.32 | 0.35 | enet | 8 | 0.32 | 9.2e-12 | -6.1 | 6.1 | 8.7e-10 | -0.05 | 1.00 | 0.00 | FALSE |
| 16 | GTEx | Colon Transverse | SRR | 0.28 | 0.21 | lasso | 5 | 0.19 | 1.6e-09 | -6.1 | 5.6 | 2.3e-08 | 0.03 | 1.00 | 0.00 | FALSE |
| 17 | GTEx | Esophagus Gastroesophageal Junction | SRR | 0.40 | 0.35 | lasso | 3 | 0.36 | 1.1e-13 | -6.1 | 6.0 | 1.5e-09 | -0.03 | 1.00 | 0.00 | FALSE |
| 18 | GTEx | Esophagus Mucosa | SRR | 0.23 | 0.24 | lasso | 5 | 0.24 | 2.0e-16 | -6.4 | 6.6 | 4.0e-11 | -0.06 | 1.00 | 0.00 | FALSE |
| 19 | GTEx | Esophagus Muscularis | SRR | 0.30 | 0.39 | lasso | 3 | 0.38 | 3.4e-24 | -6.1 | 6.0 | 1.5e-09 | -0.03 | 1.00 | 0.00 | FALSE |
| 20 | GTEx | Heart Atrial Appendage | SRR | 0.35 | 0.30 | lasso | 7 | 0.29 | 1.4e-13 | -6.4 | 5.8 | 7.6e-09 | -0.05 | 1.00 | 0.00 | FALSE |
| 21 | GTEx | Heart Left Ventricle | SRR | 0.15 | 0.16 | lasso | 3 | 0.13 | 2.9e-07 | -6.1 | 5.4 | 5.4e-08 | 0.03 | 0.94 | 0.04 | FALSE |
| 22 | GTEx | Liver | SRR | 0.31 | 0.00 | lasso | 7 | 0.00 | 3.0e-01 | -5.2 | 5.4 | 7.6e-08 | -0.40 | 0.06 | 0.14 | FALSE |
| 23 | GTEx | Lung | SRR | 0.24 | 0.28 | lasso | 2 | 0.26 | 3.4e-20 | -6.1 | 6.0 | 1.5e-09 | -0.04 | 1.00 | 0.00 | FALSE |
| 24 | GTEx | Lung | RTN4RL1 | 0.21 | 0.25 | lasso | 3 | 0.25 | 3.6e-19 | -5.1 | -5.2 | 2.5e-07 | 0.21 | 1.00 | 0.00 | FALSE |
| 25 | GTEx | Muscle Skeletal | SRR | 0.27 | 0.27 | lasso | 6 | 0.27 | 7.1e-27 | -6.1 | 6.2 | 4.5e-10 | -0.04 | 1.00 | 0.00 | FALSE |
| 26 | GTEx | Nerve Tibial | SRR | 0.15 | 0.13 | lasso | 3 | 0.13 | 2.9e-09 | -6.4 | 6.0 | 1.8e-09 | -0.06 | 1.00 | 0.00 | FALSE |
| 27 | GTEx | Pancreas | SRR | 0.13 | 0.17 | lasso | 3 | 0.15 | 5.2e-07 | -6.4 | 6.3 | 2.4e-10 | -0.06 | 0.95 | 0.00 | FALSE |
| 28 | GTEx | Skin Not Sun Exposed Suprapubic | SRR | 0.18 | 0.16 | enet | 18 | 0.19 | 7.9e-11 | -6.1 | 5.8 | 5.7e-09 | -0.04 | 0.98 | 0.00 | FALSE |
| 29 | GTEx | Skin Sun Exposed Lower leg | SRR | 0.13 | 0.15 | lasso | 4 | 0.14 | 2.0e-11 | -6.1 | 5.9 | 4.1e-09 | -0.04 | 1.00 | 0.00 | FALSE |
| 30 | GTEx | Skin Sun Exposed Lower leg | TSR1 | 0.20 | 0.05 | enet | 24 | 0.06 | 5.4e-06 | 3.0 | -5.7 | 1.5e-08 | 0.12 | 0.88 | 0.00 | FALSE |
| 31 | GTEx | Skin Sun Exposed Lower leg | RTN4RL1 | 0.19 | 0.11 | lasso | 6 | 0.11 | 2.0e-09 | -5.4 | 6.2 | 6.2e-10 | -0.28 | 1.00 | 0.00 | TRUE |
| 32 | GTEx | Spleen | SRR | 0.21 | 0.10 | lasso | 4 | 0.04 | 3.1e-02 | -6.1 | 6.4 | 1.3e-10 | -0.04 | 0.13 | 0.06 | FALSE |
| 33 | GTEx | Stomach | SRR | 0.27 | 0.30 | lasso | 7 | 0.28 | 7.1e-14 | -6.3 | 6.2 | 5.4e-10 | -0.07 | 1.00 | 0.00 | FALSE |
| 34 | GTEx | Testis | SRR | 0.13 | 0.12 | lasso | 2 | 0.09 | 6.6e-05 | -6.3 | 6.2 | 5.4e-10 | -0.07 | 0.57 | 0.02 | FALSE |
| 35 | GTEx | Thyroid | SRR | 0.26 | 0.27 | lasso | 4 | 0.25 | 2.0e-19 | -6.1 | 6.1 | 1.2e-09 | -0.03 | 1.00 | 0.00 | FALSE |
| 36 | GTEx | Whole Blood | SRR | 0.09 | 0.03 | enet | 8 | 0.02 | 4.5e-03 | -6.1 | 5.2 | 1.5e-07 | -0.04 | 0.75 | 0.01 | FALSE |
| 37 | METSIM | Adipose | SERPINF1 | 0.06 | 0.00 | bslmm | 450 | 0.02 | 2.5e-04 | -1.7 | 6.2 | 7.1e-10 | -0.19 | 0.15 | 0.24 | TRUE |
| 38 | METSIM | Adipose | SRR | 0.07 | 0.07 | enet | 21 | 0.06 | 4.4e-09 | -6.1 | 6.5 | 1.0e-10 | -0.01 | 1.00 | 0.00 | FALSE |
| 39 | ROSMAP | Brain Pre-frontal Cortex | SRR | 0.25 | 0.39 | lasso | 3 | 0.39 | 5.6e-53 | -6.1 | 6.2 | 4.0e-10 | -0.03 | 1.00 | 0.00 | FALSE |
| 40 | YFS | Blood | SRR | 0.17 | 0.22 | lasso | 7 | 0.23 | 2.5e-72 | -6.1 | 6.3 | 3.7e-10 | -0.04 | 1.00 | 0.00 | FALSE |
| 41 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | SRR | 0.11 | 0.09 | lasso | 4 | 0.10 | 6.8e-09 | -6.1 | 6.0 | 2.2e-09 | -0.04 | 0.18 | 0.82 | FALSE |
| 42 | The Cancer Genome Atlas | Breast Invasive Carcinoma | RTN4RL1 | 0.06 | 0.06 | lasso | 1 | 0.06 | 1.5e-11 | -5.2 | 5.2 | 1.7e-07 | -0.21 | 1.00 | 0.00 | FALSE |
| 43 | The Cancer Genome Atlas | Breast Invasive Carcinoma | SRR | 0.16 | 0.16 | lasso | 5 | 0.16 | 2.3e-32 | -6.4 | 6.4 | 1.2e-10 | -0.07 | 0.08 | 0.92 | FALSE |
| 44 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | SRR | 0.15 | 0.11 | blup | 61 | 0.07 | 4.0e-04 | -6.1 | 6.1 | 8.8e-10 | -0.06 | 0.13 | 0.56 | FALSE |
| 45 | The Cancer Genome Atlas | Colon Adenocarcinoma | SRR | 0.32 | 0.24 | lasso | 3 | 0.23 | 1.5e-13 | -6.1 | 6.1 | 1.0e-09 | -0.03 | 0.31 | 0.69 | FALSE |
| 46 | The Cancer Genome Atlas | Esophageal Carcinoma | SRR | 0.32 | 0.13 | lasso | 2 | 0.16 | 9.2e-06 | -6.3 | 6.2 | 4.3e-10 | -0.07 | 0.14 | 0.77 | FALSE |
| 47 | The Cancer Genome Atlas | Glioblastoma Multiforme | SRR | 0.24 | 0.16 | lasso | 1 | 0.13 | 9.0e-05 | -6.1 | 6.1 | 1.2e-09 | -0.03 | 0.06 | 0.55 | FALSE |
| 48 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | SRR | 0.10 | 0.10 | lasso | 2 | 0.09 | 1.0e-10 | -6.1 | 6.2 | 4.1e-10 | -0.04 | 0.18 | 0.82 | FALSE |
| 49 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | SRR | 0.30 | 0.40 | lasso | 7 | 0.39 | 8.5e-47 | -6.4 | 6.8 | 1.4e-11 | -0.07 | 0.07 | 0.93 | FALSE |
| 50 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | SRR | 0.22 | 0.23 | lasso | 2 | 0.21 | 2.3e-12 | -6.1 | 6.1 | 8.3e-10 | -0.03 | 0.24 | 0.76 | FALSE |
| 51 | The Cancer Genome Atlas | Brain Lower Grade Glioma | SRR | 0.29 | 0.26 | lasso | 2 | 0.27 | 1.9e-30 | -6.4 | 6.4 | 1.2e-10 | -0.07 | 0.08 | 0.92 | FALSE |
| 52 | The Cancer Genome Atlas | Liver Hepatocellular Carcinoma | SRR | 0.08 | 0.09 | enet | 3 | 0.08 | 1.7e-04 | -6.1 | 6.3 | 3.8e-10 | -0.04 | 0.08 | 0.57 | FALSE |
| 53 | The Cancer Genome Atlas | Lung Adenocarcinoma | SRR | 0.14 | 0.18 | lasso | 2 | 0.18 | 4.3e-21 | -6.1 | 6.3 | 4.0e-10 | -0.04 | 0.20 | 0.80 | FALSE |
| 54 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | SRR | 0.11 | 0.12 | lasso | 2 | 0.12 | 4.3e-13 | -6.1 | 6.1 | 8.5e-10 | -0.03 | 0.32 | 0.68 | FALSE |
| 55 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | SRR | 0.16 | 0.20 | lasso | 3 | 0.20 | 2.8e-13 | -6.4 | 6.6 | 4.6e-11 | -0.07 | 0.10 | 0.90 | FALSE |
| 56 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | SRR | 0.34 | 0.30 | lasso | 4 | 0.30 | 2.9e-13 | -6.1 | 6.2 | 4.7e-10 | -0.04 | 0.19 | 0.81 | FALSE |
| 57 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | SRR | 0.27 | 0.19 | enet | 5 | 0.21 | 8.9e-09 | -6.4 | 6.5 | 8.2e-11 | -0.07 | 0.08 | 0.91 | FALSE |
| 58 | The Cancer Genome Atlas | Prostate Adenocarcinoma | SRR | 0.30 | 0.35 | lasso | 3 | 0.36 | 7.5e-39 | -6.1 | 6.3 | 2.2e-10 | -0.04 | 0.22 | 0.78 | FALSE |
| 59 | The Cancer Genome Atlas | Soft Tissue Sarcoma | SRR | 0.20 | 0.18 | lasso | 2 | 0.20 | 8.8e-12 | -6.1 | 6.3 | 2.5e-10 | -0.05 | 0.14 | 0.86 | FALSE |
| 60 | The Cancer Genome Atlas | Skin Cutaneous Melanoma | SRR | 0.16 | 0.03 | blup | 61 | 0.02 | 8.7e-02 | -6.3 | 7.1 | 1.6e-12 | -0.07 | 0.01 | 0.57 | FALSE |
| 61 | The Cancer Genome Atlas | Stomach Adenocarcinoma | SRR | 0.21 | 0.15 | enet | 11 | 0.16 | 1.1e-11 | -6.4 | 5.9 | 2.8e-09 | -0.03 | 0.08 | 0.92 | FALSE |
| 62 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | SGSM2 | 0.13 | 0.01 | blup | 81 | 0.01 | 1.1e-01 | 6.3 | -7.1 | 1.1e-12 | 0.08 | 0.01 | 0.65 | FALSE |
| 63 | The Cancer Genome Atlas | Thyroid Carcinoma | SRR | 0.56 | 0.50 | lasso | 4 | 0.50 | 5.2e-55 | -6.1 | 6.2 | 5.6e-10 | -0.03 | 0.40 | 0.60 | FALSE |