TWAS hub - TSR1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Skin Sun Exposed Lower leg	0.2020	0.0520	7.9e-06	0.054	NA	0.064	NA	0.051	2.6e-05	NA	5.4e-06	NA	4.8e-05
2	NTR	Blood	0.0356	0.0134	7.6e-04	0.001	0.009	0.001	0.01	-0.001	1.4e-01	0.00045	1.3e-01	0.00031	7.8e-01

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Nervous feelings	9.8	18.3	34.1	-1.6	5.8
Suffer from ‘nerves’	6.9	10.9	11.0	-3.3	3.3
Worry (Nagel 2018)	5.8	12.2	18.5	-2.4	4.3
Comparative body size at age 10	5.8	16.0	29.3	-5.4	1.7
Ever had prostate specific antigen (PSA) test	5.6	6.4	11.8	1.0	3.4
Neuroticism (Nagel 2018)	4.9	11.6	20.4	-1.7	4.5
Impedance of leg (left)	4.7	22.9	45.7	6.8	-0.4
Impedance of leg (right)	4.4	21.2	42.4	6.5	-0.3
Neuroticism score	4.1	8.5	15.3	-1.3	3.9
Neuroticism (2016)	4.0	5.7	11.1	-0.6	3.3
Worrier / anxious feelings	3.8	7.1	10.4	-1.9	3.2
Frequency of tenseness / restlessness in last 2 weeks	3.7	5.8	9.4	-1.4	3.1
Qualifications: O levels/GCSEs or equivalent	3.6	5.7	10.2	1.1	-3.2
Diastolic blood pressure, automated reading	3.5	10.9	20.7	-4.5	1.1
Basal cell carcinoma (self-reported)	3.5	4.2	4.2	2.0	-2.0
Allergy or Eczema	3.4	9.0	15.4	3.9	-1.6
Diabetes (father)	3.4	4.3	7.7	0.9	-2.8
Tense / ‘highly strung’	3.4	5.6	10.1	-1.1	3.2
Hair/balding pattern: Pattern 4	3.4	8.3	11.0	-2.4	3.3
Knee pain experienced in last month	3.4	5.3	10.2	-3.2	0.6
Neuroticism	3.3	8.0	14.5	-1.2	3.8
Supplements: Glucosamine	3.3	4.3	7.9	-2.8	-0.8
Hayfever/allergic rhinitis (self-reported)	3.3	4.3	7.2	1.2	-2.7
Frequency of depressed mood in last 2 weeks	3.2	4.5	5.5	-2.3	1.9
Worry too long after embarrassment	3.1	5.3	10.2	0.5	3.2
Smoking Status	3.0	7.2	8.3	2.5	-2.9
Depressed Affect (Nagel 2018)	2.9	6.0	9.9	-1.4	3.1
Systolic blood pressure, automated reading	2.9	8.3	11.3	-3.4	2.3
Average weekly fortified wine intake	2.9	3.4	5.3	2.3	-1.2
Medication: Gliclazide	2.9	3.2	6.0	-2.5	0.7
BMI	2.8	16.4	32.0	-5.7	0.9
Gout (self-reported)	2.6	3.5	7.0	-2.6	0.3
Alzheimer’s Disease (in father)	2.5	2.7	2.7	-1.6	-1.6
Schizophrenia (2014)	2.5	5.6	10.8	3.3	0.5
Loneliness, isolation	2.5	3.5	5.9	-1.0	2.4
Eye problems/disorders: None of the above	2.4	2.8	3.2	-1.6	1.8
Commuting to job workplace: Car/motor vehicle	2.4	2.7	5.4	-2.3	-0.1
Unable to work because of sickness or disability	2.4	3.2	6.1	-0.5	2.5
Ulcerative Colitis	2.3	3.3	6.0	2.4	0.8
Arm fat percentage (right)	2.3	9.2	17.9	-4.2	-0.7
Arm fat mass (right)	2.3	9.4	18.2	-4.3	-0.7
Medication: Amlodipine	2.3	3.3	6.3	-0.5	2.5
Commuting to job workplace: Cycle	2.3	2.8	2.9	1.7	-1.6
Leg fat-free mass (left)	2.2	11.7	23.3	-4.8	0.3
Leg predicted mass (left)	2.2	11.6	23.2	-4.8	0.3
Birth weight	2.2	4.7	5.2	-2.3	2.0
Leg predicted mass (right)	2.2	11.8	23.5	-4.8	0.3
Schizophrenia (2018)	2.1	4.3	8.5	2.9	0.2
Age when periods started (menarche)	2.1	5.0	10.0	3.2	0.3
Body mass index (BMI)	2.1	8.9	17.1	-4.1	-0.8
Leg fat-free mass (right)	2.1	11.4	22.7	-4.8	0.3
Smoking status: Current	2.1	3.4	5.1	2.3	-1.3
Coronary Artery Disease (CAD)	2.0	2.4	3.0	-1.7	1.3
Bilateral oophorectomy (both ovaries removed)	2.0	2.3	4.2	-2.0	-0.7
Hayfever, allergic rhinitis or eczema	2.0	4.3	5.2	2.3	-1.8
Ever highly irritable/argumentative for 2 days	2.0	2.4	2.4	1.5	1.5
Medication: Aspirin	2.0	2.6	2.6	-1.6	1.6
Arm fat mass (left)	2.0	8.1	15.6	-3.9	-0.8
Impedance of whole body	2.0	10.3	20.0	4.5	0.8
Sensitivity / hurt feelings	1.9	3.2	6.3	-0.3	2.5
Current tobacco smoking	1.9	3.2	5.5	2.4	-0.9
Relative age voice broke	1.9	2.9	4.6	2.1	1.1
Waist circumference	1.9	7.0	13.9	-3.7	-0.3
Alcohol intake versus 10 years previously	1.9	2.8	5.0	-2.2	0.8
Medication: Aspirin	1.9	2.5	2.9	-1.7	1.5
Arm fat percentage (left)	1.9	7.4	14.7	-3.8	-0.4
Osteoporosis (self-reported)	1.9	2.4	4.3	0.6	2.1
Miserableness	1.9	3.3	5.4	-1.1	2.3
Depression (Nagel 2018)	1.8	2.7	3.4	-1.4	1.8
Happiness	1.8	2.2	4.0	2.0	0.7
Depression (self-reported)	1.8	2.1	4.2	0.3	2.1
Seen a psychiatrist for nerves, anxiety, tension or depression	1.8	2.3	4.5	-0.4	2.1
Mood swings	1.8	3.3	5.5	-1.0	2.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.8	3.7	7.2	-2.7	0.5
Irritable Bowel Disease (IBD)	1.7	4.2	4.8	2.2	1.9
Ever smoked	1.7	3.0	5.6	0.7	-2.4
Alcohol drinker status: Previous	1.7	1.9	3.7	0.4	1.9
Body Mass Index (BMI) (2010)	1.6	2.2	2.8	-1.7	1.2
Weight	1.6	7.9	15.4	-3.9	-0.7
Number of full sisters	1.6	1.9	3.8	2.0	0.1
Ever depressed for a whole week	1.6	2.0	2.2	1.5	1.4
Hair/balding pattern: Pattern 2	1.5	1.9	3.0	1.7	-0.9
Financial difficulties in last 2 years	1.5	2.0	4.0	2.0	-0.0
Crohns Disease (2012)	1.4	2.2	4.2	2.0	0.4
Heel T-Score	1.4	10.8	21.5	-4.6	0.3
Systolic Blood Pressure	1.4	7.0	7.8	-2.8	2.5
Townsend deprivation index at recruitment	1.4	1.9	2.7	1.6	-1.0
Frequency of unenthusiasm / disinterest in last 2 weeks	1.4	1.8	2.0	-1.3	1.4
High blood pressure (siblings)	1.4	2.1	4.0	-2.0	0.3
Commuting to job workplace: Walk	1.4	1.5	3.0	1.7	0.0
Basal metabolic rate	1.4	7.7	15.0	-3.9	-0.6
Risk taking	1.4	2.0	2.8	1.7	-1.1
Medication: Omeprazole (e.g. Zanprol)	1.4	1.7	2.0	1.2	-1.4
Bipolar Disorder or Schizophrenia	1.3	3.2	6.1	2.5	0.7
Crohns Disease (2017)	1.3	2.8	3.3	1.8	1.6
High blood pressure	1.3	3.7	4.1	-2.0	1.8
Trunk fat mass	1.3	5.8	11.5	-3.4	-0.2
Alcohol usually taken with meals	1.3	2.1	3.7	-0.6	-1.9
Heel bone mineral density (BMD) T-score, automated (right)	1.3	2.9	4.3	-2.1	-1.2
Allergy	1.3	2.9	3.3	-1.6	1.8
Peak expiratory flow (PEF)	1.3	3.1	3.2	-1.8	-1.7
Glaucoma (self-reported)	1.3	1.5	1.8	1.1	-1.3
Chronic bronchitis/emphysema (mother)	1.3	1.5	3.0	1.7	-0.1
Number of full brothers	1.3	1.7	2.3	1.0	1.5
Number of children fathered	1.3	1.5	2.9	-1.7	0.0
Whole body fat mass	1.3	5.6	11.1	-3.3	-0.2
Had major operations	1.3	1.5	2.8	-1.7	0.5
Whole body fat-free mass	1.3	7.3	14.3	-3.8	-0.5
Whole body water mass	1.3	7.3	14.2	-3.8	-0.6
Eye problems/disorders: Glaucoma	1.3	1.5	2.3	0.9	-1.5
Vascular/heart problems diagnosed by doctor	1.3	3.6	4.8	2.2	-1.6
Ulcerative Colitis (UC)	1.2	2.2	3.1	1.7	1.2
Lung FVC	1.2	5.9	8.6	-2.9	1.8
Supplements: Zinc	1.2	1.3	1.4	1.1	-1.2
Qualifications: A levels/AS levels or equivalent	1.2	2.7	3.1	1.5	-1.8
Medication: Lansoprazole	1.2	1.3	2.3	-1.5	0.6
Illness, injury, bereavement, stress in last 2 years	1.2	1.5	2.7	-1.6	-0.4
Wears glasses or contact lenses	1.2	1.4	2.1	0.9	1.5
Fed-up feelings	1.1	2.0	3.4	-0.7	1.9
Serious illness, injury or assault to yourself	1.1	1.3	2.5	-0.4	1.6
Number of incorrect matches in round	1.1	1.8	2.8	1.7	0.9
Medication: Ventolin 100micrograms inhaler	1.1	1.4	2.4	-0.7	-1.6
Hypertension (Self-reported)	1.1	3.0	3.2	-1.7	1.8
Long-standing illness, disability or infirmity	1.1	1.6	2.0	-1.1	1.4
Guilty feelings	1.1	1.7	3.3	0.1	1.8
Mother’s age at death	1.1	1.3	2.0	-0.8	1.4
Relative age of first facial hair	1.0	2.0	3.0	1.7	1.0
Heel bone mineral density (BMD) T-score, automated (left)	1.0	2.2	3.7	-1.9	-0.8
Past tobacco smoking	1.0	1.8	2.9	-0.9	1.7
Had menopause	1.0	1.2	2.0	0.7	1.4
Forced vital capacity (FVC)	1.0	3.9	5.8	-2.4	1.4
Diabetes (self-reported)	1.0	1.5	2.2	-0.9	1.5
Mouth/teeth dental problems: Bleeding gums	1.0	1.3	1.9	-1.4	0.9
Forced vital capacity (FVC), Best measure	1.0	3.7	7.0	-2.6	0.7
Qualifications: nursing, teaching	1.0	1.5	2.2	1.5	-0.9
HDL Cholesterol	0.9	1.4	2.9	1.7	-0.1
LDL Cholesterol	0.9	1.5	2.7	1.7	-0.4
Blood Red Count	0.9	8.8	16.8	-0.9	-4.1
Other serious medical condition/disability diagnosed by doctor	0.9	1.2	2.3	-0.3	1.5
Eye problems/disorders: Diabetes related eye disease	0.9	1.0	1.0	1.0	1.0
Vitamin and mineral supplements	0.9	1.3	2.3	-0.5	1.5
Trunk fat percentage	0.9	3.6	7.3	-2.7	-0.0
Tinnitus: Yes, but not now, but have in the past	0.9	1.0	1.1	0.9	-1.0
Had other major operations	0.9	1.1	1.9	0.6	-1.4
Mouth/teeth dental problems	0.9	1.3	2.6	0.1	-1.6
Medication: Simvastatin	0.9	1.3	2.3	1.5	-0.6
Frequency of tiredness / lethargy in last 2 weeks	0.9	1.4	2.3	-0.8	1.5
Impedance of arm (left)	0.9	4.0	4.1	2.0	1.9
Mouth/teeth dental problems: Loose teeth	0.9	1.1	1.4	-1.2	-0.9
Leg fat mass (right)	0.9	3.5	6.2	-2.5	-0.9
Ever had bowel cancer screening	0.9	1.0	2.0	-1.4	-0.3
High cholesterol (Self-reported)	0.9	1.5	1.6	1.2	-1.3
Arm fat-free mass (left)	0.9	4.5	7.8	-2.8	-1.1
Leg fat mass (left)	0.9	3.4	6.2	-2.5	-0.7
Arm predicted mass (left)	0.9	4.7	7.7	-2.8	-1.3
Major Depression (MDD)	0.8	0.9	1.3	0.8	1.1
Waist Hip Ratio (WHR)	0.8	3.8	7.3	-2.7	0.5
Lung FEV1/FVC ratio	0.8	4.0	7.8	2.8	0.5
Trunk fat-free mass	0.8	4.8	8.8	-3.0	-0.9
Hip circumference	0.8	3.5	6.8	-2.6	-0.3
Illnesses of mother	0.8	1.0	2.0	1.4	-0.1
Trunk predicted mass	0.8	4.7	8.5	-2.9	-0.9
Seen doctor (GP) for nerves, anxiety, tension or depression	0.8	1.3	2.3	0.5	1.5
Pulse wave reflection index	0.8	1.0	1.9	1.4	-0.4
Medication: Blood pressure	0.8	1.4	2.8	-0.1	1.7
Medication: Omeprazole	0.8	0.9	1.6	0.5	-1.3
Supplements: Calcium	0.8	0.8	1.5	-0.4	1.2
HbA1C	0.7	0.8	1.2	-0.6	1.1
Type 2 Diabetes (T2D) (2012)	0.7	0.8	1.2	-1.1	0.6
Chronotype (morning person)	0.7	1.7	2.7	1.6	0.8
Hand grip strength (left)	0.7	1.9	2.5	-1.2	1.6
Average weekly spirits intake	0.7	0.9	1.0	-0.8	1.0
Severe depression (siblings)	0.7	0.7	1.4	1.2	-0.3
Maternal smoking around birth	0.7	1.0	1.8	0.4	-1.3
Qualifications: CSEs or equivalent	0.7	0.9	1.2	0.8	-1.1
Forced expiratory volume in 1-second (FEV1)	0.7	2.2	3.2	-1.8	1.1
Serious illness, injury or assault of a close relative in last 2 years	0.7	0.8	1.1	1.1	-0.7
Forced expiratory volume in 1-second (FEV1), Best measure	0.7	2.4	4.4	-2.1	0.5
Exposure to tobacco smoke at home	0.7	0.8	1.5	1.2	-0.1
Breastfed as a baby	0.7	0.8	1.6	-1.3	-0.2
Medication: Paracetamol	0.7	1.2	2.1	1.5	-0.5
Body fat percentage	0.7	2.9	5.8	-2.4	-0.3
Reason for reducing amount of alcohol drunk: Health precaution	0.7	0.9	1.2	-0.7	-1.1
Health satisfaction	0.7	0.9	1.6	-0.5	1.2
Medication: Ibuprofen	0.7	0.8	1.6	1.3	0.3
Smoking status: Previous	0.7	1.1	1.9	0.5	-1.4
Handedness (chirality/laterality): Left-handed	0.7	0.9	1.7	-0.1	-1.3
Tinnitus: Yes, now most or all of the time	0.7	0.8	1.7	-0.1	1.3
Medication: Paracetamol	0.7	1.0	1.7	1.3	0.6
Heart disease (siblings)	0.7	0.9	1.3	-0.7	-1.1
Medication: Co-codamol	0.6	0.7	1.0	1.0	-0.7
Diverticular disease/diverticulitis (self-reported)	0.6	0.8	1.3	0.5	-1.1
Chronic bronchitis/emphysema (father)	0.6	0.7	1.5	0.1	1.2
Ever unenthusiastic/disinterested for a whole week	0.6	0.8	1.3	-0.4	1.2
Father’s age at death	0.6	0.8	1.3	0.5	-1.1
Number of live births	0.6	0.9	1.6	1.3	-0.3
Medication: Allopurinol	0.6	0.8	1.5	-1.2	0.2
Arm predicted mass (right)	0.6	3.0	5.8	-2.4	-0.4
Chest pain or discomfort	0.6	0.9	1.5	0.5	-1.2
Leg pain on walking	0.6	0.8	1.0	-0.8	1.0
Supplements: Vitamin C	0.6	0.7	1.3	-0.4	-1.2
Friendships satisfaction	0.6	0.8	1.5	1.2	0.3
Breast cancer (self-reported)	0.6	0.8	1.5	-1.2	0.1
Medication: Lisinopril	0.6	0.8	1.3	1.2	0.6
Alcohol drinker status: Never	0.6	0.7	0.9	-0.7	0.9
Number of operations (self-reported)	0.6	0.9	1.6	-1.3	0.3
Fractured/broken bones in last 5 years	0.6	0.7	1.4	0.2	1.2
Ovarian Cancer	0.5	0.6	0.8	0.6	-0.9
Primary Biliary Cirrhosis	0.5	0.7	1.2	1.1	-0.3
Diabetes (mother)	0.5	0.6	1.0	-1.0	0.5
Medication: Ibuprofen (e.g. Nurofen)	0.5	0.6	1.0	1.0	-0.3
Medication for cholesterol, blood pressure or diabetes	0.5	0.9	1.4	-0.6	-1.2
Leg fat percentage (right)	0.5	1.6	2.1	-1.1	-1.4
Arm fat-free mass (right)	0.5	2.6	4.7	-2.2	-0.7
Wheeze or whistling in the chest in last year	0.5	0.9	1.1	-0.8	-1.1
Medication for pain relief, constipation, heartburn	0.5	0.9	1.6	-1.3	-0.3
Comparative height size at age 10	0.5	2.5	3.9	-2.0	1.0
Illnesses of father: Heart disease	0.5	0.7	1.1	-1.0	-0.5
Eye problems/disorders: Cataract	0.5	0.6	1.0	0.5	-1.0
Mouth/teeth dental problems: Mouth ulcers	0.5	0.8	1.3	1.1	0.5
Cholesterol lowering medication	0.5	0.7	1.0	0.5	-1.0
Alzheimer’s Disease (including proxy)	0.4	0.6	1.2	-1.1	-0.3
Breast Cancer	0.4	1.0	2.0	-0.0	-1.4
Cardiovascular Disease	0.4	1.3	1.3	-1.1	1.1
Respiratory disease	0.4	0.9	1.6	-0.5	-1.3
Hearing difficulty/problems: Yes	0.4	0.6	0.8	0.6	-0.9
Angina	0.4	0.5	1.0	-1.0	-0.2
Taking other prescription medications	0.4	0.6	1.0	-0.4	-1.0
Sitting height	0.4	2.9	4.3	-2.1	1.2
High blood pressure (mother)	0.4	0.5	1.0	-1.0	0.4
Illnesses of siblings	0.4	0.5	1.1	1.0	-0.0
Impedance of arm (right)	0.4	1.9	2.5	1.2	1.6
Falls in the last year	0.4	0.5	0.8	-0.5	0.9
Loud music exposure frequency	0.4	0.4	0.8	0.3	0.9
Exposure to tobacco smoke outside home	0.4	0.6	1.0	-1.0	0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.4	0.4	0.8	-0.9	-0.0
Overall health rating	0.4	0.9	0.9	-1.0	0.9
Average weekly red wine intake	0.4	0.6	0.7	-0.8	0.8
Ever had stillbirth, spontaneous miscarriage or termination	0.4	0.5	0.9	0.1	1.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.4	0.4	0.5	-0.6	0.7
Mineral and other dietary supplements	0.4	0.6	0.6	0.7	0.8
Osteoarthritis (self-reported)	0.4	0.5	0.8	-0.3	-0.9
Illnesses of father: None of the above (group 1)	0.4	0.5	1.0	1.0	0.2
Leg fat percentage (left)	0.4	1.5	1.8	-1.1	-1.3
Irritability	0.4	0.6	0.9	-0.6	-0.9
Bipolar Disorder (2018)	0.3	0.4	0.7	0.3	0.9
Schizophrenia vs Biploar Disorder	0.3	0.3	0.6	0.8	-0.3
Prostate Cancer	0.3	0.4	0.8	0.1	-0.9
Lupus	0.3	0.5	0.8	0.5	-0.9
Blood Eosinophil Count	0.3	2.2	4.4	-2.1	-0.2
Blood Platelet Count	0.3	3.4	6.6	2.6	0.4
Ever had hysterectomy (womb removed)	0.3	0.3	0.5	0.4	-0.7
Medication for hormone replacement therapy	0.3	0.3	0.5	-0.7	-0.1
Heart attack	0.3	0.4	0.6	-0.8	0.3
Pain all over the body in last month	0.3	0.3	0.6	-0.3	0.8
Noisy workplace	0.3	0.3	0.5	0.4	-0.7
Medication: Cholesterol lowering	0.3	0.4	0.4	0.7	-0.6
Prospective memory result	0.3	0.4	0.4	-0.6	0.6
Birth weight of first child	0.3	0.6	1.1	-0.2	1.0
Age at first live birth	0.3	0.5	0.9	-1.0	-0.1
Angina (self-reported)	0.3	0.4	0.8	-0.9	-0.0
Age at last live birth	0.3	0.4	0.7	-0.9	-0.0
Family relationship satisfaction	0.3	0.3	0.5	0.7	-0.4
Medication for cholesterol	0.3	0.5	0.5	0.7	0.7
Back pain experienced in last month	0.3	0.4	0.5	0.7	-0.5
Financial situation satisfaction	0.3	0.4	0.4	0.6	-0.6
Verbal and Numeric Reasoning (VNR)	0.2	0.5	0.6	-0.6	0.8
Rheumatoid Arthritis	0.2	0.2	0.3	-0.5	0.4
Tanning	0.2	1.9	3.1	-1.8	0.9
Hand grip strength (right)	0.2	0.4	0.8	-0.9	0.2
Multivitamins +/- minerals	0.2	0.3	0.5	-0.2	-0.7
Stomach or abdominal pain in last month	0.2	0.3	0.4	0.3	0.6
Qualifications: None of the above	0.2	0.4	0.4	-0.6	0.6
Pulse rate	0.2	0.3	0.4	0.6	-0.5
Mouth/teeth dental problems: Dentures	0.2	0.3	0.7	0.0	0.8
Blood clot in the leg (DVT)	0.2	0.3	0.6	0.1	-0.8
Headache pain in last month	0.2	0.3	0.5	0.4	-0.7
Pulse wave peak to peak time	0.2	0.2	0.3	0.2	-0.6
Shortness of breath walking on level ground	0.2	0.3	0.3	0.5	0.5
Emphysema/chronic bronchitis	0.2	0.3	0.4	-0.3	-0.7
Neck or shoulder pain in last month	0.2	0.3	0.4	0.7	0.5
Migraine (self-reported)	0.2	0.3	0.4	0.7	0.3
Qualifications: NVQ or HND or HNC or equivalent	0.2	0.2	0.5	0.1	-0.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.2	0.2	0.3	0.3	-0.6
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.4	0.7	-0.1	0.8
Diabetes diagnosed by doctor	0.2	0.3	0.5	-0.4	0.7
Commuting to job workplace: Public transport	0.2	0.2	0.2	0.5	0.5
Medication: Blood pressure	0.2	0.4	0.7	-0.8	-0.4
Medication: Bendroflumethiazide	0.2	0.3	0.6	-0.3	-0.7
Medication: Atorvastatin	0.2	0.3	0.5	0.2	-0.7
Myopia	0.2	0.3	0.3	-0.5	-0.5
Heart attack/myocardial infarction (self-reported)	0.2	0.3	0.3	-0.6	0.6
Intelligence (Savage-Jansen 2018)	0.1	0.3	0.6	0.8	-0.2
Alzheimer’s Disease (in mother)	0.1	0.1	0.1	-0.4	0.1
Reaction Time	0.1	0.1	0.3	-0.5	0.1
Age at First Birth	0.1	0.2	0.2	-0.4	0.5
Mean Putamen Volume	0.1	0.1	0.2	-0.3	0.4
Fasting Glucose	0.1	0.1	0.1	-0.3	0.3
Blood White Count	0.1	0.9	1.6	0.3	-1.3
Hypothyroidism (self reported)	0.1	0.3	0.6	0.3	-0.8
Type 2 Diabetes (T2D) (2018)	0.1	0.2	0.3	-0.5	0.3
Number of treatments/medications taken	0.1	0.2	0.5	-0.0	0.7
Ever used hormone-replacement therapy (HRT)	0.1	0.1	0.2	0.4	-0.1
Medication: Atenolol	0.1	0.2	0.3	-0.6	0.2
Hearing difficulty/problems with background noise	0.1	0.1	0.3	0.5	0.1
Medication: Ramipril	0.1	0.1	0.1	-0.3	-0.3
Hair/balding pattern: Pattern 3	0.1	0.2	0.3	0.6	0.2
Lung cancer (father)	0.1	0.1	0.1	-0.0	-0.4
Pulse wave Arterial Stiffness index	0.1	0.1	0.2	0.1	0.4
Qualifications: College or University degree	0.1	0.4	0.9	0.1	0.9
Medication: Seretide 50 evohaler	0.1	0.1	0.2	0.4	0.0
Mean time to correctly identify matches	0.1	0.2	0.4	-0.6	-0.1
Heart disease (mother)	0.1	0.1	0.2	-0.4	-0.2
Pulse rate, automated reading	0.1	0.4	0.6	0.8	0.5
Alcohol intake frequency.	0.1	0.3	0.4	-0.5	0.7
Illnesses of siblings: Diabetes	0.1	0.1	0.1	0.2	-0.3
Asthma (self-reported)	0.1	0.1	0.3	-0.0	-0.5
Number of self-reported non-cancer illnesses	0.1	0.2	0.4	-0.1	-0.7
Average weekly champagne plus white wine intake	0.1	0.1	0.1	-0.3	0.3
Ever taken oral contraceptive pill	0.1	0.1	0.1	-0.4	0.2
Illnesses of father: High blood pressure	0.1	0.1	0.2	-0.4	0.2
Average weekly beer plus cider intake	0.1	0.2	0.3	-0.6	-0.0
Age started oral contraceptive pill	0.1	0.1	0.1	-0.1	0.4
Pain experienced in last month	0.1	0.1	0.2	0.2	0.4
Deep venous thrombosis (DVT) (self-reported)	0.1	0.2	0.3	0.2	-0.6
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0
Triglycerides	0.0	0.0	0.0	-0.1	0.0
Height	0.0	0.1	0.1	-0.3	0.4
Hair Pigment	0.0	0.8	1.6	-1.2	0.1
Medication: Metformin	0.0	0.0	0.1	-0.3	-0.1
Pack years adult smoking proportion	0.0	0.0	0.0	-0.1	0.2
Medication: Levothyroxine sodium	0.0	0.0	0.0	-0.1	-0.1
Fluid intelligence score	0.0	0.1	0.1	-0.2	0.3
Time employed in main current job	0.0	0.0	0.0	0.0	-0.0
Asthma	0.0	0.1	0.1	-0.1	-0.4
Standing height	0.0	0.1	0.2	-0.2	0.5
Length of working week for main job	0.0	0.0	0.1	-0.2	0.2
Hypothyroidism/myxoedema (self-reported)	0.0	0.1	0.1	0.4	0.1
Hearing aid user	0.0	0.0	0.0	0.2	0.2
Pain type(s) experienced in last month: Hip pain	0.0	0.0	0.1	0.3	0.1
Supplements: Fish oil (including cod liver oil)	0.0	0.0	0.1	0.1	-0.2
Pack years of smoking	0.0	0.0	0.0	-0.1	0.1

Hub : Genes

TSR1

Models

Trait associations