[Hub]/) : Traits : BMI :

chr17:34,146,026-36,441,093

Best TWAS P=6.34e-19 · Best GWAS P=2.87e-17 conditioned to 0.0195

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex DHRS11 0.22 0.24 bslmm 311 0.25 1.6e-30 -8.3 6.4 1.9e-10 0.62 0.01 0.99 FALSE
2 CommonMind Brain Pre-frontal Cortex MYO19 0.05 0.05 lasso 2 0.05 8.4e-07 -7.7 7.8 4.4e-15 0.82 0.22 0.77 FALSE
3 GTEx Adipose Subcutaneous GGNBP2 0.10 0.11 enet 9 0.11 3.5e-09 8.0 -8.7 4.6e-18 -0.92 0.04 0.96 FALSE
4 GTEx Adipose Subcutaneous MYO19 0.07 0.05 enet 10 0.03 1.3e-03 8.0 8.5 2.6e-17 0.94 0.03 0.97 FALSE
5 GTEx Adipose Visceral Omentum GGNBP2 0.13 0.12 enet 11 0.13 1.9e-07 -8.0 -7.7 1.5e-14 -0.80 0.06 0.94 FALSE
6 GTEx Adipose Visceral Omentum DHRS11 0.10 0.00 lasso 4 0.00 1.7e-01 -8.2 -5.2 1.5e-07 -0.69 0.08 0.75 FALSE
7 GTEx Adipose Visceral Omentum MYO19 0.12 0.02 lasso 4 0.04 5.2e-03 2.8 5.8 6.9e-09 0.63 0.03 0.69 FALSE
8 GTEx Artery Aorta GGNBP2 0.13 0.12 lasso 4 0.12 2.4e-07 -8.4 -8.4 4.1e-17 -0.82 0.02 0.98 FALSE
9 GTEx Artery Aorta DHRS11 0.10 0.07 lasso 5 0.06 2.7e-04 -8.4 8.4 5.1e-17 0.79 0.02 0.97 FALSE
10 GTEx Artery Aorta MYO19 0.20 0.16 enet 9 0.15 1.6e-08 -7.7 7.2 6.7e-13 0.88 0.17 0.83 FALSE
11 GTEx Artery Tibial GGNBP2 0.12 0.12 enet 15 0.12 1.2e-09 -8.3 -8.4 5.7e-17 -0.85 0.02 0.98 FALSE
12 GTEx Artery Tibial DHRS11 0.14 0.08 enet 11 0.11 7.1e-09 -8.0 8.2 2.8e-16 0.86 0.03 0.97 FALSE
13 GTEx Artery Tibial MYO19 0.12 0.11 lasso 6 0.13 4.1e-10 8.0 8.6 9.2e-18 0.93 0.06 0.94 FALSE
14 GTEx Brain Caudate basal ganglia DHRS11 0.18 0.12 lasso 4 0.02 9.2e-02 -8.0 8.2 1.7e-16 0.79 0.02 0.85 FALSE
15 GTEx Brain Cerebellar Hemisphere CTB-75G16.3 0.27 0.14 lasso 4 0.05 1.8e-02 -8.1 -7.9 3.1e-15 -0.73 0.02 0.79 FALSE
16 GTEx Brain Cerebellum DHRS11 0.33 0.23 lasso 4 0.20 1.9e-06 -8.3 8.3 1.5e-16 0.77 0.02 0.98 FALSE
17 GTEx Brain Cortex DHRS11 0.23 0.18 enet 24 0.18 8.5e-06 -8.4 8.2 1.8e-16 0.76 0.02 0.98 FALSE
18 GTEx Brain Cortex CTB-75G16.3 0.32 0.15 lasso 8 0.14 1.4e-04 -7.7 -5.8 9.0e-09 -0.70 0.17 0.44 FALSE
19 GTEx Brain Frontal Cortex BA9 DHRS11 0.34 0.26 enet 19 0.25 2.5e-07 -8.3 7.8 4.3e-15 0.76 0.02 0.98 FALSE
20 GTEx Brain Hypothalamus DHRS11 0.24 0.12 lasso 2 0.12 1.1e-03 -8.2 8.0 1.1e-15 0.84 0.03 0.89 FALSE
21 GTEx Brain Nucleus accumbens basal ganglia DHRS11 0.18 0.20 lasso 3 0.15 8.8e-05 -8.1 8.1 6.8e-16 0.77 0.02 0.95 FALSE
22 GTEx Breast Mammary Tissue GGNBP2 0.08 0.06 lasso 2 0.03 7.8e-03 -7.7 -8.7 5.1e-18 -0.73 0.03 0.84 FALSE
23 GTEx Breast Mammary Tissue CTB-75G16.3 0.12 0.04 enet 9 0.06 7.2e-04 2.6 -5.1 3.0e-07 -0.62 0.05 0.88 FALSE
24 GTEx Cells EBV-transformed lymphocytes GGNBP2 0.13 0.15 lasso 2 0.13 5.5e-05 -8.2 -8.2 2.8e-16 -0.84 0.02 0.94 FALSE
25 GTEx Cells EBV-transformed lymphocytes DHRS11 0.14 0.08 enet 3 0.07 3.2e-03 -8.2 8.2 3.1e-16 0.84 0.03 0.84 FALSE
26 GTEx Cells EBV-transformed lymphocytes ZNHIT3 0.31 0.32 enet 9 0.22 1.1e-07 8.0 8.3 6.7e-17 0.92 0.10 0.90 FALSE
27 GTEx Cells Transformed fibroblasts GGNBP2 0.11 0.10 enet 12 0.10 4.5e-08 -8.0 -7.2 8.0e-13 -0.84 0.03 0.97 FALSE
28 GTEx Cells Transformed fibroblasts DHRS11 0.11 0.08 lasso 2 0.08 2.7e-06 -8.3 7.7 1.3e-14 0.75 0.02 0.98 FALSE
29 GTEx Cells Transformed fibroblasts ZNHIT3 0.15 0.07 lasso 7 0.05 1.7e-04 8.0 7.6 2.9e-14 0.91 0.08 0.88 FALSE
30 GTEx Cells Transformed fibroblasts ACACA 0.09 0.01 lasso 4 0.00 2.6e-01 4.5 5.3 1.3e-07 -0.01 0.11 0.12 TRUE
31 GTEx Colon Transverse GGNBP2 0.15 0.15 enet 13 0.11 4.8e-06 -8.4 -7.3 2.5e-13 -0.78 0.02 0.98 FALSE
32 GTEx Colon Transverse MYO19 0.13 0.12 lasso 2 0.11 8.0e-06 8.5 8.2 2.6e-16 0.98 0.01 0.99 FALSE
33 GTEx Esophagus Gastroesophageal Junction GGNBP2 0.12 0.12 lasso 2 0.09 4.9e-04 -8.3 -8.4 5.7e-17 -0.77 0.02 0.94 FALSE
34 GTEx Esophagus Mucosa GGNBP2 0.16 0.16 enet 15 0.18 3.1e-12 -7.5 -8.8 8.6e-19 -0.88 0.05 0.95 FALSE
35 GTEx Esophagus Mucosa DHRS11 0.12 0.08 lasso 2 0.06 5.1e-05 8.5 8.8 1.5e-18 0.97 0.01 0.99 FALSE
36 GTEx Esophagus Mucosa ZNHIT3 0.22 0.13 enet 15 0.08 8.1e-06 8.0 7.0 1.8e-12 0.84 0.06 0.94 FALSE
37 GTEx Esophagus Mucosa MYO19 0.11 0.08 enet 12 0.04 1.2e-03 8.0 7.5 6.3e-14 0.92 0.03 0.96 FALSE
38 GTEx Esophagus Muscularis GGNBP2 0.15 0.11 enet 13 0.14 1.4e-08 8.0 -8.3 8.4e-17 -0.82 0.05 0.94 FALSE
39 GTEx Esophagus Muscularis DHRS11 0.14 0.08 lasso 5 0.08 8.2e-06 -8.0 8.5 2.2e-17 0.94 0.02 0.98 FALSE
40 GTEx Esophagus Muscularis MYO19 0.14 0.14 enet 8 0.15 2.8e-09 8.5 8.3 1.5e-16 0.97 0.02 0.98 FALSE
41 GTEx Heart Atrial Appendage MYO19 0.13 0.12 lasso 1 0.11 1.1e-05 -8.0 8.0 1.4e-15 0.86 0.04 0.95 FALSE
42 GTEx Heart Left Ventricle DHRS11 0.13 0.10 lasso 1 0.08 3.3e-05 -8.1 8.1 5.6e-16 0.80 0.02 0.98 FALSE
43 GTEx Heart Left Ventricle MYO19 0.10 0.06 lasso 3 0.04 5.4e-03 8.5 8.0 1.1e-15 0.96 0.02 0.95 FALSE
44 GTEx Lung GGNBP2 0.08 0.01 enet 8 0.01 3.3e-02 8.5 -8.7 2.9e-18 -0.93 0.02 0.98 FALSE
45 GTEx Lung DHRS11 0.09 0.08 lasso 5 0.10 3.7e-08 -8.0 8.5 2.5e-17 0.86 0.02 0.98 FALSE
46 GTEx Lung MYO19 0.15 0.14 enet 8 0.13 2.1e-10 8.0 7.8 5.7e-15 0.93 0.10 0.90 FALSE
47 GTEx Muscle Skeletal GGNBP2 0.08 0.06 enet 14 0.05 2.5e-05 -7.5 -7.3 2.4e-13 -0.77 0.06 0.94 FALSE
48 GTEx Muscle Skeletal DHRS11 0.09 0.08 lasso 3 0.09 9.3e-09 -8.0 8.3 1.4e-16 0.82 0.03 0.97 FALSE
49 GTEx Muscle Skeletal MYO19 0.04 0.05 enet 14 0.03 6.4e-04 -7.7 7.4 1.1e-13 0.79 0.09 0.87 FALSE
50 GTEx Nerve Tibial GGNBP2 0.10 0.04 lasso 3 0.05 2.4e-04 8.0 -8.4 4.8e-17 -0.92 0.03 0.97 FALSE
51 GTEx Nerve Tibial MYO19 0.11 0.11 enet 8 0.08 1.4e-06 8.0 7.9 3.5e-15 0.92 0.15 0.85 FALSE
52 GTEx Pancreas GGNBP2 0.15 0.09 lasso 2 0.07 5.1e-04 -8.1 -8.2 3.3e-16 -0.82 0.03 0.97 FALSE
53 GTEx Skin Sun Exposed Lower leg GGNBP2 0.11 0.06 enet 11 0.10 1.3e-08 -7.5 -8.3 1.1e-16 -0.85 0.05 0.95 FALSE
54 GTEx Skin Sun Exposed Lower leg MYO19 0.07 0.01 enet 7 0.03 1.8e-03 8.0 7.3 2.2e-13 0.88 0.12 0.86 FALSE
55 GTEx Stomach GGNBP2 0.13 0.06 lasso 3 0.06 5.9e-04 -7.7 -8.1 6.0e-16 -0.81 0.03 0.94 FALSE
56 GTEx Testis GGNBP2 0.19 0.19 lasso 1 0.15 3.8e-07 -8.1 -8.1 5.6e-16 -0.80 0.02 0.98 FALSE
57 GTEx Testis ZNHIT3 0.27 0.33 lasso 2 0.32 8.0e-15 8.0 -8.0 1.2e-15 -0.93 0.10 0.90 FALSE
58 GTEx Thyroid GGNBP2 0.07 0.06 lasso 2 0.04 2.8e-04 -8.4 -8.6 1.1e-17 -0.82 0.02 0.98 FALSE
59 GTEx Thyroid MYO19 0.11 0.05 lasso 3 0.04 7.1e-04 -7.7 7.6 3.9e-14 0.79 0.07 0.83 FALSE
60 GTEx Whole Blood GGNBP2 0.08 0.01 lasso 4 0.01 3.6e-02 -8.0 -7.8 4.9e-15 -0.85 0.04 0.83 FALSE
61 METSIM Adipose GGNBP2 0.16 0.14 lasso 5 0.14 6.2e-21 8.0 -8.3 1.1e-16 -0.92 0.17 0.83 FALSE
62 METSIM Adipose MYO19 0.10 0.10 lasso 4 0.10 1.6e-14 8.0 8.1 4.8e-16 0.92 0.16 0.84 FALSE
63 NTR Blood GGNBP2 0.03 0.02 bslmm 331 0.02 7.7e-07 -7.5 -8.9 6.3e-19 -0.79 0.06 0.94 TRUE
64 YFS Blood DHRS11 0.05 0.06 lasso 7 0.06 2.5e-18 -8.0 8.5 2.2e-17 0.80 0.22 0.78 FALSE
65 YFS Blood GGNBP2 0.07 0.09 enet 21 0.10 4.7e-31 8.0 -7.8 7.9e-15 -0.90 0.16 0.84 FALSE
66 YFS Blood MYO19 0.12 0.14 enet 14 0.14 4.0e-45 7.9 7.6 2.2e-14 0.91 0.20 0.80 FALSE
67 The Cancer Genome Atlas Breast Invasive Carcinoma GGNBP2 0.02 0.00 enet 13 0.01 1.0e-03 -8.0 -5.3 1.1e-07 -0.50 0.01 0.33 FALSE
68 The Cancer Genome Atlas Breast Invasive Carcinoma ZNHIT3 0.01 0.00 lasso 3 0.01 4.2e-03 8.0 5.8 5.4e-09 0.81 0.01 0.46 FALSE
69 The Cancer Genome Atlas Cervical Squamous Cell Carcinoma GGNBP2 0.20 0.06 enet 5 0.07 3.2e-04 -8.1 -5.5 5.2e-08 -0.50 0.02 0.79 FALSE
70 The Cancer Genome Atlas Colon Adenocarcinoma GGNBP2 0.10 0.05 lasso 3 0.06 2.5e-04 -7.5 -7.4 1.4e-13 -0.80 0.04 0.74 FALSE
71 The Cancer Genome Atlas Colon Adenocarcinoma MRM1 0.06 0.06 enet 4 0.05 9.4e-04 -8.3 -8.2 1.7e-16 -0.78 0.00 0.95 FALSE
72 The Cancer Genome Atlas Esophageal Carcinoma DHRS11 0.12 0.12 blup 13 0.12 1.5e-04 -8.3 7.4 1.3e-13 0.59 0.00 0.94 FALSE
73 The Cancer Genome Atlas Esophageal Carcinoma ZNHIT3 0.11 0.11 lasso 4 0.09 6.2e-04 -8.1 8.1 4.5e-16 0.78 0.01 0.76 FALSE
74 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma ZNHIT3 0.05 0.03 enet 4 0.04 4.7e-05 8.5 8.8 1.3e-18 0.97 0.00 1.00 FALSE
75 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma DHRS11 0.04 0.04 lasso 2 0.04 3.1e-05 -8.3 8.3 9.7e-17 0.78 0.00 1.00 FALSE
76 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma GGNBP2 0.04 0.04 enet 3 0.04 6.3e-05 8.0 -8.7 4.2e-18 -0.90 0.01 0.98 FALSE
77 The Cancer Genome Atlas Brain Lower Grade Glioma DHRS11 0.05 0.11 enet 6 0.10 7.4e-12 -8.1 8.3 8.1e-17 0.81 0.00 1.00 FALSE
78 The Cancer Genome Atlas Liver Hepatocellular Carcinoma GGNBP2 0.05 0.04 lasso 2 0.01 8.1e-02 -8.1 -8.2 3.1e-16 -0.80 0.01 0.75 FALSE
79 The Cancer Genome Atlas Lung Squamous Cell Carcinoma ZNHIT3 0.03 0.03 enet 4 0.03 1.8e-04 -8.1 8.4 3.5e-17 0.83 0.01 0.93 FALSE
80 The Cancer Genome Atlas Pancreatic Adenocarcinoma ZNHIT3 0.19 -0.01 enet 13 0.10 8.2e-05 8.0 5.6 2.6e-08 0.47 0.01 0.24 FALSE
81 The Cancer Genome Atlas Prostate Adenocarcinoma GGNBP2 0.02 0.02 enet 4 0.02 6.0e-03 -7.5 -8.0 1.3e-15 -0.88 0.01 0.78 FALSE
82 The Cancer Genome Atlas Stomach Adenocarcinoma ZNHIT3 0.06 0.03 enet 2 0.04 1.3e-03 -8.0 8.2 3.2e-16 0.85 0.02 0.91 FALSE
83 The Cancer Genome Atlas Testicular Germ Cell Tumors DHRS11 0.06 0.06 blup 12 0.04 2.0e-02 -8.1 7.8 4.0e-15 0.68 0.00 0.69 FALSE
84 The Cancer Genome Atlas Thyroid Carcinoma GGNBP2 0.04 0.04 enet 6 0.05 1.4e-05 -8.0 -8.5 1.5e-17 -0.88 0.01 0.98 FALSE