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chr17:34,146,026-36,441,093

Best TWAS P=6.34e-19 · Best GWAS P=2.87e-17 conditioned to 0.0195

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	DHRS11	0.22	0.24	bslmm	311	0.25	1.6e-30	-8.3	6.4	1.9e-10	0.62	0.01	0.99	FALSE
2	CommonMind	Brain Pre-frontal Cortex	MYO19	0.05	0.05	lasso	2	0.05	8.4e-07	-7.7	7.8	4.4e-15	0.82	0.22	0.77	FALSE
3	GTEx	Adipose Subcutaneous	GGNBP2	0.10	0.11	enet	9	0.11	3.5e-09	8.0	-8.7	4.6e-18	-0.92	0.04	0.96	FALSE
4	GTEx	Adipose Subcutaneous	MYO19	0.07	0.05	enet	10	0.03	1.3e-03	8.0	8.5	2.6e-17	0.94	0.03	0.97	FALSE
5	GTEx	Adipose Visceral Omentum	GGNBP2	0.13	0.12	enet	11	0.13	1.9e-07	-8.0	-7.7	1.5e-14	-0.80	0.06	0.94	FALSE
6	GTEx	Adipose Visceral Omentum	DHRS11	0.10	0.00	lasso	4	0.00	1.7e-01	-8.2	-5.2	1.5e-07	-0.69	0.08	0.75	FALSE
7	GTEx	Adipose Visceral Omentum	MYO19	0.12	0.02	lasso	4	0.04	5.2e-03	2.8	5.8	6.9e-09	0.63	0.03	0.69	FALSE
8	GTEx	Artery Aorta	GGNBP2	0.13	0.12	lasso	4	0.12	2.4e-07	-8.4	-8.4	4.1e-17	-0.82	0.02	0.98	FALSE
9	GTEx	Artery Aorta	DHRS11	0.10	0.07	lasso	5	0.06	2.7e-04	-8.4	8.4	5.1e-17	0.79	0.02	0.97	FALSE
10	GTEx	Artery Aorta	MYO19	0.20	0.16	enet	9	0.15	1.6e-08	-7.7	7.2	6.7e-13	0.88	0.17	0.83	FALSE
11	GTEx	Artery Tibial	GGNBP2	0.12	0.12	enet	15	0.12	1.2e-09	-8.3	-8.4	5.7e-17	-0.85	0.02	0.98	FALSE
12	GTEx	Artery Tibial	DHRS11	0.14	0.08	enet	11	0.11	7.1e-09	-8.0	8.2	2.8e-16	0.86	0.03	0.97	FALSE
13	GTEx	Artery Tibial	MYO19	0.12	0.11	lasso	6	0.13	4.1e-10	8.0	8.6	9.2e-18	0.93	0.06	0.94	FALSE
14	GTEx	Brain Caudate basal ganglia	DHRS11	0.18	0.12	lasso	4	0.02	9.2e-02	-8.0	8.2	1.7e-16	0.79	0.02	0.85	FALSE
15	GTEx	Brain Cerebellar Hemisphere	CTB-75G16.3	0.27	0.14	lasso	4	0.05	1.8e-02	-8.1	-7.9	3.1e-15	-0.73	0.02	0.79	FALSE
16	GTEx	Brain Cerebellum	DHRS11	0.33	0.23	lasso	4	0.20	1.9e-06	-8.3	8.3	1.5e-16	0.77	0.02	0.98	FALSE
17	GTEx	Brain Cortex	DHRS11	0.23	0.18	enet	24	0.18	8.5e-06	-8.4	8.2	1.8e-16	0.76	0.02	0.98	FALSE
18	GTEx	Brain Cortex	CTB-75G16.3	0.32	0.15	lasso	8	0.14	1.4e-04	-7.7	-5.8	9.0e-09	-0.70	0.17	0.44	FALSE
19	GTEx	Brain Frontal Cortex BA9	DHRS11	0.34	0.26	enet	19	0.25	2.5e-07	-8.3	7.8	4.3e-15	0.76	0.02	0.98	FALSE
20	GTEx	Brain Hypothalamus	DHRS11	0.24	0.12	lasso	2	0.12	1.1e-03	-8.2	8.0	1.1e-15	0.84	0.03	0.89	FALSE
21	GTEx	Brain Nucleus accumbens basal ganglia	DHRS11	0.18	0.20	lasso	3	0.15	8.8e-05	-8.1	8.1	6.8e-16	0.77	0.02	0.95	FALSE
22	GTEx	Breast Mammary Tissue	GGNBP2	0.08	0.06	lasso	2	0.03	7.8e-03	-7.7	-8.7	5.1e-18	-0.73	0.03	0.84	FALSE
23	GTEx	Breast Mammary Tissue	CTB-75G16.3	0.12	0.04	enet	9	0.06	7.2e-04	2.6	-5.1	3.0e-07	-0.62	0.05	0.88	FALSE
24	GTEx	Cells EBV-transformed lymphocytes	GGNBP2	0.13	0.15	lasso	2	0.13	5.5e-05	-8.2	-8.2	2.8e-16	-0.84	0.02	0.94	FALSE
25	GTEx	Cells EBV-transformed lymphocytes	DHRS11	0.14	0.08	enet	3	0.07	3.2e-03	-8.2	8.2	3.1e-16	0.84	0.03	0.84	FALSE
26	GTEx	Cells EBV-transformed lymphocytes	ZNHIT3	0.31	0.32	enet	9	0.22	1.1e-07	8.0	8.3	6.7e-17	0.92	0.10	0.90	FALSE
27	GTEx	Cells Transformed fibroblasts	GGNBP2	0.11	0.10	enet	12	0.10	4.5e-08	-8.0	-7.2	8.0e-13	-0.84	0.03	0.97	FALSE
28	GTEx	Cells Transformed fibroblasts	DHRS11	0.11	0.08	lasso	2	0.08	2.7e-06	-8.3	7.7	1.3e-14	0.75	0.02	0.98	FALSE
29	GTEx	Cells Transformed fibroblasts	ZNHIT3	0.15	0.07	lasso	7	0.05	1.7e-04	8.0	7.6	2.9e-14	0.91	0.08	0.88	FALSE
30	GTEx	Cells Transformed fibroblasts	ACACA	0.09	0.01	lasso	4	0.00	2.6e-01	4.5	5.3	1.3e-07	-0.01	0.11	0.12	TRUE
31	GTEx	Colon Transverse	GGNBP2	0.15	0.15	enet	13	0.11	4.8e-06	-8.4	-7.3	2.5e-13	-0.78	0.02	0.98	FALSE
32	GTEx	Colon Transverse	MYO19	0.13	0.12	lasso	2	0.11	8.0e-06	8.5	8.2	2.6e-16	0.98	0.01	0.99	FALSE
33	GTEx	Esophagus Gastroesophageal Junction	GGNBP2	0.12	0.12	lasso	2	0.09	4.9e-04	-8.3	-8.4	5.7e-17	-0.77	0.02	0.94	FALSE
34	GTEx	Esophagus Mucosa	GGNBP2	0.16	0.16	enet	15	0.18	3.1e-12	-7.5	-8.8	8.6e-19	-0.88	0.05	0.95	FALSE
35	GTEx	Esophagus Mucosa	DHRS11	0.12	0.08	lasso	2	0.06	5.1e-05	8.5	8.8	1.5e-18	0.97	0.01	0.99	FALSE
36	GTEx	Esophagus Mucosa	ZNHIT3	0.22	0.13	enet	15	0.08	8.1e-06	8.0	7.0	1.8e-12	0.84	0.06	0.94	FALSE
37	GTEx	Esophagus Mucosa	MYO19	0.11	0.08	enet	12	0.04	1.2e-03	8.0	7.5	6.3e-14	0.92	0.03	0.96	FALSE
38	GTEx	Esophagus Muscularis	GGNBP2	0.15	0.11	enet	13	0.14	1.4e-08	8.0	-8.3	8.4e-17	-0.82	0.05	0.94	FALSE
39	GTEx	Esophagus Muscularis	DHRS11	0.14	0.08	lasso	5	0.08	8.2e-06	-8.0	8.5	2.2e-17	0.94	0.02	0.98	FALSE
40	GTEx	Esophagus Muscularis	MYO19	0.14	0.14	enet	8	0.15	2.8e-09	8.5	8.3	1.5e-16	0.97	0.02	0.98	FALSE
41	GTEx	Heart Atrial Appendage	MYO19	0.13	0.12	lasso	1	0.11	1.1e-05	-8.0	8.0	1.4e-15	0.86	0.04	0.95	FALSE
42	GTEx	Heart Left Ventricle	DHRS11	0.13	0.10	lasso	1	0.08	3.3e-05	-8.1	8.1	5.6e-16	0.80	0.02	0.98	FALSE
43	GTEx	Heart Left Ventricle	MYO19	0.10	0.06	lasso	3	0.04	5.4e-03	8.5	8.0	1.1e-15	0.96	0.02	0.95	FALSE
44	GTEx	Lung	GGNBP2	0.08	0.01	enet	8	0.01	3.3e-02	8.5	-8.7	2.9e-18	-0.93	0.02	0.98	FALSE
45	GTEx	Lung	DHRS11	0.09	0.08	lasso	5	0.10	3.7e-08	-8.0	8.5	2.5e-17	0.86	0.02	0.98	FALSE
46	GTEx	Lung	MYO19	0.15	0.14	enet	8	0.13	2.1e-10	8.0	7.8	5.7e-15	0.93	0.10	0.90	FALSE
47	GTEx	Muscle Skeletal	GGNBP2	0.08	0.06	enet	14	0.05	2.5e-05	-7.5	-7.3	2.4e-13	-0.77	0.06	0.94	FALSE
48	GTEx	Muscle Skeletal	DHRS11	0.09	0.08	lasso	3	0.09	9.3e-09	-8.0	8.3	1.4e-16	0.82	0.03	0.97	FALSE
49	GTEx	Muscle Skeletal	MYO19	0.04	0.05	enet	14	0.03	6.4e-04	-7.7	7.4	1.1e-13	0.79	0.09	0.87	FALSE
50	GTEx	Nerve Tibial	GGNBP2	0.10	0.04	lasso	3	0.05	2.4e-04	8.0	-8.4	4.8e-17	-0.92	0.03	0.97	FALSE
51	GTEx	Nerve Tibial	MYO19	0.11	0.11	enet	8	0.08	1.4e-06	8.0	7.9	3.5e-15	0.92	0.15	0.85	FALSE
52	GTEx	Pancreas	GGNBP2	0.15	0.09	lasso	2	0.07	5.1e-04	-8.1	-8.2	3.3e-16	-0.82	0.03	0.97	FALSE
53	GTEx	Skin Sun Exposed Lower leg	GGNBP2	0.11	0.06	enet	11	0.10	1.3e-08	-7.5	-8.3	1.1e-16	-0.85	0.05	0.95	FALSE
54	GTEx	Skin Sun Exposed Lower leg	MYO19	0.07	0.01	enet	7	0.03	1.8e-03	8.0	7.3	2.2e-13	0.88	0.12	0.86	FALSE
55	GTEx	Stomach	GGNBP2	0.13	0.06	lasso	3	0.06	5.9e-04	-7.7	-8.1	6.0e-16	-0.81	0.03	0.94	FALSE
56	GTEx	Testis	GGNBP2	0.19	0.19	lasso	1	0.15	3.8e-07	-8.1	-8.1	5.6e-16	-0.80	0.02	0.98	FALSE
57	GTEx	Testis	ZNHIT3	0.27	0.33	lasso	2	0.32	8.0e-15	8.0	-8.0	1.2e-15	-0.93	0.10	0.90	FALSE
58	GTEx	Thyroid	GGNBP2	0.07	0.06	lasso	2	0.04	2.8e-04	-8.4	-8.6	1.1e-17	-0.82	0.02	0.98	FALSE
59	GTEx	Thyroid	MYO19	0.11	0.05	lasso	3	0.04	7.1e-04	-7.7	7.6	3.9e-14	0.79	0.07	0.83	FALSE
60	GTEx	Whole Blood	GGNBP2	0.08	0.01	lasso	4	0.01	3.6e-02	-8.0	-7.8	4.9e-15	-0.85	0.04	0.83	FALSE
61	METSIM	Adipose	GGNBP2	0.16	0.14	lasso	5	0.14	6.2e-21	8.0	-8.3	1.1e-16	-0.92	0.17	0.83	FALSE
62	METSIM	Adipose	MYO19	0.10	0.10	lasso	4	0.10	1.6e-14	8.0	8.1	4.8e-16	0.92	0.16	0.84	FALSE
63	NTR	Blood	GGNBP2	0.03	0.02	bslmm	331	0.02	7.7e-07	-7.5	-8.9	6.3e-19	-0.79	0.06	0.94	TRUE
64	YFS	Blood	DHRS11	0.05	0.06	lasso	7	0.06	2.5e-18	-8.0	8.5	2.2e-17	0.80	0.22	0.78	FALSE
65	YFS	Blood	GGNBP2	0.07	0.09	enet	21	0.10	4.7e-31	8.0	-7.8	7.9e-15	-0.90	0.16	0.84	FALSE
66	YFS	Blood	MYO19	0.12	0.14	enet	14	0.14	4.0e-45	7.9	7.6	2.2e-14	0.91	0.20	0.80	FALSE
67	The Cancer Genome Atlas	Breast Invasive Carcinoma	GGNBP2	0.02	0.00	enet	13	0.01	1.0e-03	-8.0	-5.3	1.1e-07	-0.50	0.01	0.33	FALSE
68	The Cancer Genome Atlas	Breast Invasive Carcinoma	ZNHIT3	0.01	0.00	lasso	3	0.01	4.2e-03	8.0	5.8	5.4e-09	0.81	0.01	0.46	FALSE
69	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	GGNBP2	0.20	0.06	enet	5	0.07	3.2e-04	-8.1	-5.5	5.2e-08	-0.50	0.02	0.79	FALSE
70	The Cancer Genome Atlas	Colon Adenocarcinoma	GGNBP2	0.10	0.05	lasso	3	0.06	2.5e-04	-7.5	-7.4	1.4e-13	-0.80	0.04	0.74	FALSE
71	The Cancer Genome Atlas	Colon Adenocarcinoma	MRM1	0.06	0.06	enet	4	0.05	9.4e-04	-8.3	-8.2	1.7e-16	-0.78	0.00	0.95	FALSE
72	The Cancer Genome Atlas	Esophageal Carcinoma	DHRS11	0.12	0.12	blup	13	0.12	1.5e-04	-8.3	7.4	1.3e-13	0.59	0.00	0.94	FALSE
73	The Cancer Genome Atlas	Esophageal Carcinoma	ZNHIT3	0.11	0.11	lasso	4	0.09	6.2e-04	-8.1	8.1	4.5e-16	0.78	0.01	0.76	FALSE
74	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	ZNHIT3	0.05	0.03	enet	4	0.04	4.7e-05	8.5	8.8	1.3e-18	0.97	0.00	1.00	FALSE
75	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	DHRS11	0.04	0.04	lasso	2	0.04	3.1e-05	-8.3	8.3	9.7e-17	0.78	0.00	1.00	FALSE
76	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	GGNBP2	0.04	0.04	enet	3	0.04	6.3e-05	8.0	-8.7	4.2e-18	-0.90	0.01	0.98	FALSE
77	The Cancer Genome Atlas	Brain Lower Grade Glioma	DHRS11	0.05	0.11	enet	6	0.10	7.4e-12	-8.1	8.3	8.1e-17	0.81	0.00	1.00	FALSE
78	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	GGNBP2	0.05	0.04	lasso	2	0.01	8.1e-02	-8.1	-8.2	3.1e-16	-0.80	0.01	0.75	FALSE
79	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	ZNHIT3	0.03	0.03	enet	4	0.03	1.8e-04	-8.1	8.4	3.5e-17	0.83	0.01	0.93	FALSE
80	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	ZNHIT3	0.19	-0.01	enet	13	0.10	8.2e-05	8.0	5.6	2.6e-08	0.47	0.01	0.24	FALSE
81	The Cancer Genome Atlas	Prostate Adenocarcinoma	GGNBP2	0.02	0.02	enet	4	0.02	6.0e-03	-7.5	-8.0	1.3e-15	-0.88	0.01	0.78	FALSE
82	The Cancer Genome Atlas	Stomach Adenocarcinoma	ZNHIT3	0.06	0.03	enet	2	0.04	1.3e-03	-8.0	8.2	3.2e-16	0.85	0.02	0.91	FALSE
83	The Cancer Genome Atlas	Testicular Germ Cell Tumors	DHRS11	0.06	0.06	blup	12	0.04	2.0e-02	-8.1	7.8	4.0e-15	0.68	0.00	0.69	FALSE
84	The Cancer Genome Atlas	Thyroid Carcinoma	GGNBP2	0.04	0.04	enet	6	0.05	1.4e-05	-8.0	-8.5	1.5e-17	-0.88	0.01	0.98	FALSE