TWAS hub - MRM1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Artery Tibial	0.1038	0.0442	4.5e-03	0.040	NA	-0.003	NA	0.010	0.00044	NA	0.65000	NA	0.05400
2	GTEx	Cells Transformed fibroblasts	0.1770	0.0500	1.7e-05	0.021	NA	0.035	NA	0.031	0.00980	NA	0.00110	NA	0.00230
3	TCGA	Bladder Urothelial Carcinoma	0.0470	0.0270	6.9e-03	0.016	0.003	0.014	NA	0.014	0.01400	1.6e-01	0.02200	NA	0.02100
4	TCGA	Colon Adenocarcinoma	0.0580	0.0320	3.7e-03	0.056	0.038	0.048	NA	0.047	0.00037	2.9e-03	0.00094	NA	0.00098
5	TCGA	Head and Neck Squamous Cell Carcinoma	0.0395	0.0226	3.4e-03	0.009	0.002	0.019	NA	0.014	0.02900	1.6e-01	0.00290	NA	0.00940
6	TCGA	Kidney Renal Clear Cell Carcinoma	0.0348	0.0186	3.3e-03	0.018	0.006	0.028	NA	0.025	0.00320	6.9e-02	0.00038	NA	0.00067
7	TCGA	Brain Lower Grade Glioma	0.0422	0.0206	4.8e-04	0.027	0.039	0.032	NA	0.030	0.00047	2.5e-05	0.00014	NA	0.00023

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Maternal smoking around birth	5.1	7.3	20.1	3.7	2.0	1.1	-4.5	2.0	1.6	2.3
Tense / ‘highly strung’	5.0	8.3	12.6	-3.0	-3.3	-3.4	2.2	-1.8	-3.6	-2.6
Illnesses of mother	4.7	5.8	23.2	-2.6	-0.4	1.7	4.8	1.8	1.6	1.3
Verbal and Numeric Reasoning (VNR)	4.2	10.0	30.2	-4.1	-2.6	-1.5	5.5	-2.0	-1.8	-2.7
Number of incorrect matches in round	4.2	7.0	13.1	2.2	-2.2	-3.6	-2.7	-2.1	-3.2	-2.2
High blood pressure (siblings)	4.0	5.8	11.0	1.6	-1.4	-3.3	-1.7	-2.5	-3.0	-2.6
Illnesses of siblings	3.7	5.3	8.9	-1.9	1.1	3.0	2.9	1.9	2.6	2.1
Tinnitus: Yes, now most or all of the time	3.3	3.8	7.3	0.0	-0.9	-2.7	-1.3	-2.2	-2.5	-2.4
Waist circumference	3.1	11.2	59.4	2.7	2.8	-0.1	-7.7	1.1	0.5	1.5
Medication: Ventolin 100micrograms inhaler	3.1	4.0	7.5	0.6	1.6	2.7	0.1	2.2	2.5	2.5
Qualifications: O levels/GCSEs or equivalent	3.0	4.8	17.5	-4.2	-0.8	0.7	3.8	-0.0	0.0	-0.3
Fluid intelligence score	2.9	6.1	25.4	-3.1	-1.6	-0.7	5.0	-0.9	-1.0	-1.5
Comparative body size at age 10	2.8	7.6	38.6	1.6	1.0	-1.9	-6.2	-1.6	-2.0	-0.9
Body Mass Index (BMI) (2010)	2.7	3.7	15.4	1.8	2.4	0.0	-3.9	0.0	0.6	1.2
Body mass index (BMI)	2.7	11.4	65.8	2.7	2.5	-0.3	-8.1	0.1	0.2	0.9
Intelligence (Savage-Jansen 2018)	2.6	7.9	31.2	-3.2	-2.5	-1.2	5.6	-0.7	-1.4	-1.9
Medication: Lansoprazole	2.6	3.0	5.8	1.5	2.4	1.6	-2.1	0.9	1.5	1.6
Leg fat mass (right)	2.6	10.1	61.7	2.1	2.0	-0.8	-7.9	-0.2	-0.1	0.4
Leg fat mass (left)	2.6	10.2	62.3	1.9	2.1	-0.8	-7.9	-0.3	-0.1	0.4
Noisy workplace	2.5	3.1	12.9	2.4	1.4	0.5	-3.6	-0.5	0.6	0.3
Had major operations	2.5	3.0	5.5	0.8	1.9	1.8	-0.7	2.3	1.9	2.0
Depression (Nagel 2018)	2.4	3.7	9.3	-2.8	-1.8	-0.8	3.0	-0.9	-1.3	-1.4
Length of working week for main job	2.4	2.6	5.3	-0.5	-1.0	-2.2	-0.3	-1.8	-2.3	-1.9
Arm fat percentage (right)	2.3	9.0	49.2	2.7	2.3	0.1	-7.0	0.3	0.5	0.8
Arm fat mass (right)	2.3	9.5	54.5	2.6	2.1	-0.3	-7.4	0.2	0.2	0.8
Mineral and other dietary supplements	2.3	3.1	5.8	-1.3	-1.4	-2.0	-0.1	-2.0	-2.4	-2.2
Arm fat mass (left)	2.3	9.4	52.4	2.5	2.4	-0.0	-7.2	0.3	0.4	0.9
BMI	2.2	12.8	67.9	3.1	3.0	0.2	-8.2	0.4	1.0	1.4
Supplements: Glucosamine	2.2	2.9	5.4	0.7	2.3	1.8	-0.7	1.9	1.8	1.9
Leg fat percentage (right)	2.2	7.9	47.2	2.0	1.7	-0.9	-6.9	-0.6	-0.2	0.1
Exposure to tobacco smoke outside home	2.2	2.9	8.4	-1.2	-2.9	-1.6	0.8	-1.4	-1.5	-1.7
Chronotype (morning person)	2.1	4.9	6.4	2.5	2.4	1.9	-2.2	2.2	1.8	2.3
Frequency of depressed mood in last 2 weeks	2.1	3.0	4.3	-2.1	-1.8	-1.6	1.8	-1.4	-1.6	-1.7
Qualifications: None of the above	2.1	4.5	20.2	2.5	1.8	-0.9	-4.5	-0.7	-0.6	-0.2
Qualifications: A levels/AS levels or equivalent	2.1	4.7	13.6	-3.1	0.6	1.7	3.7	1.6	1.6	1.0
Migraine (self-reported)	2.1	2.6	5.8	2.4	1.1	1.4	-1.8	1.0	1.5	1.5
Whole body fat mass	2.1	8.7	52.6	1.9	1.8	-0.9	-7.3	-0.2	-0.2	0.3
Arm fat percentage (left)	2.1	8.2	45.4	2.5	2.3	-0.0	-6.7	0.2	0.4	0.7
Supplements: Fish oil (including cod liver oil)	2.1	2.7	4.8	1.2	1.3	2.0	0.2	1.7	2.2	1.9
Leg fat percentage (left)	2.1	7.8	47.5	1.5	1.8	-0.8	-6.9	-0.6	-0.1	-0.0
Allergy or Eczema	2.0	5.3	20.5	-2.3	-2.9	-0.8	4.5	-0.6	-0.7	-1.2
Chronic bronchitis/emphysema (mother)	2.0	2.3	5.0	-0.3	-0.7	-2.2	-1.4	-1.4	-2.0	-1.6
Number of full sisters	2.0	2.5	4.6	0.3	-1.3	-2.2	-0.8	-1.9	-1.8	-1.9
Supplements: Vitamin C	2.0	2.3	3.7	-0.9	1.0	1.9	1.8	1.4	1.8	1.5
Body fat percentage	1.9	7.6	45.2	1.9	1.9	-0.8	-6.7	-0.3	-0.1	0.2
Number of children fathered	1.9	2.1	4.5	1.4	0.1	-1.1	-2.1	-2.0	-1.2	-1.2
Age at First Birth	1.8	2.6	5.9	0.7	0.5	2.0	0.7	2.4	1.5	2.2
Primary Biliary Cirrhosis	1.8	2.6	8.9	2.6	1.6	0.0	-3.0	0.0	0.0	0.0
Ever used hormone-replacement therapy (HRT)	1.8	2.3	8.4	2.2	-0.2	-1.0	-2.9	-0.6	-1.3	-0.5
High blood pressure (mother)	1.8	2.6	14.0	1.5	0.6	-0.6	-3.7	-1.0	-0.4	-0.3
Ever had stillbirth, spontaneous miscarriage or termination	1.8	1.9	4.9	-1.4	0.3	1.3	2.2	1.7	1.0	1.1
Friendships satisfaction	1.8	2.2	3.8	-1.2	-1.9	-1.4	1.9	-1.0	-1.3	-1.4
Commuting to job workplace: Public transport	1.8	2.2	5.3	0.6	0.3	1.3	2.3	1.9	1.4	1.5
Pain type(s) experienced in last month: Hip pain	1.8	2.2	5.1	1.2	2.3	0.8	-1.6	1.6	0.9	1.6
Multivitamins +/- minerals	1.7	2.2	4.0	-0.5	0.2	1.8	1.2	1.8	2.0	1.7
Waist Hip Ratio (WHR)	1.6	7.1	10.0	3.1	2.4	1.7	-3.2	3.0	1.7	3.1
Angina	1.6	2.1	3.8	-0.6	-0.9	-1.7	-0.5	-1.9	-2.0	-1.8
Trunk fat percentage	1.6	6.5	38.1	2.0	1.7	-0.8	-6.2	-0.2	-0.3	0.1
Hayfever, allergic rhinitis or eczema	1.6	3.4	15.2	-2.0	-2.1	-0.3	3.9	0.0	-0.1	-0.5
Trunk fat mass	1.6	6.9	41.8	1.7	1.6	-0.8	-6.5	-0.2	-0.2	0.2
Exposure to tobacco smoke at home	1.6	1.7	3.7	-1.1	-1.9	-1.5	-0.5	-1.3	-0.8	-1.5
Worry too long after embarrassment	1.6	2.8	4.5	-0.5	-1.3	-1.8	1.3	-2.1	-1.8	-2.1
Seen a psychiatrist for nerves, anxiety, tension or depression	1.6	2.1	8.5	-2.9	-1.2	-1.1	1.2	-0.5	-0.9	-1.0
Qualifications: College or University degree	1.6	5.1	20.0	-2.1	0.0	2.0	4.5	1.5	1.9	1.1
Commuting to job workplace: Cycle	1.6	1.9	3.8	1.0	0.9	1.5	0.4	1.9	1.7	1.6
Type 2 Diabetes (T2D) (2018)	1.5	2.7	4.7	0.8	2.2	1.5	-1.6	1.7	1.3	2.0
Number of treatments/medications taken	1.5	2.7	8.0	0.9	2.8	1.3	-2.5	0.7	1.0	1.1
Vitamin and mineral supplements	1.5	2.0	5.3	1.1	-0.1	-1.5	-2.3	-1.2	-1.7	-1.0
Pack years adult smoking proportion	1.5	2.2	8.0	1.9	-0.4	-1.0	-2.8	-1.2	-0.9	-0.7
Knee pain experienced in last month	1.5	2.3	4.6	0.5	-1.3	-1.8	-2.1	-1.4	-1.3	-1.5
Qualifications: nursing, teaching	1.5	2.3	5.2	-1.2	1.2	2.2	1.4	0.9	2.3	1.0
Irritability	1.5	2.5	8.8	-2.1	-1.6	-0.8	3.0	0.5	-0.9	-0.4
Medication: Metformin	1.4	2.0	5.7	0.6	1.6	1.1	-2.4	1.3	0.4	1.5
Weight	1.4	6.9	41.6	1.4	1.8	-0.1	-6.5	0.6	0.4	1.0
Father’s age at death	1.4	1.9	8.6	0.6	-0.6	1.0	2.9	1.3	0.7	1.0
Depression (self-reported)	1.4	1.6	6.3	-2.5	-1.3	-0.4	1.2	-0.9	-0.5	-0.9
Mouth/teeth dental problems: Loose teeth	1.4	1.7	3.1	1.1	-1.8	-1.7	-0.4	-0.8	-1.7	-1.0
Number of operations (self-reported)	1.4	2.1	2.8	0.8	1.6	1.5	-1.5	1.4	1.6	1.7
LDL Cholesterol	1.3	2.0	5.4	1.0	2.3	0.0	-1.8	0.0	1.4	1.6
Ulcerative Colitis	1.3	1.9	5.5	0.6	0.2	0.0	-2.3	0.0	-2.1	-1.8
Heart attack	1.3	1.7	3.8	0.7	1.9	1.2	-0.8	1.3	1.3	1.4
Reason for reducing amount of alcohol drunk: Health precaution	1.3	1.5	3.7	-1.7	-0.7	-0.5	1.9	-1.1	-0.8	-1.1
Angina (self-reported)	1.3	1.8	3.5	-0.5	-0.6	-1.5	-0.7	-1.9	-1.8	-1.6
Mother’s age at death	1.3	1.7	9.3	-0.9	-0.9	0.7	3.1	-0.1	0.5	-0.3
Medication: Paracetamol	1.3	1.9	6.0	0.8	2.5	0.6	-2.0	1.0	0.4	1.1
Neuroticism (Nagel 2018)	1.2	2.9	4.2	-1.6	-1.8	-1.6	2.1	-1.2	-1.8	-1.6
Hayfever/allergic rhinitis (self-reported)	1.2	1.6	2.9	-0.5	0.9	1.7	0.5	1.5	1.7	1.3
Asthma	1.2	2.4	11.2	-1.3	-0.1	1.1	3.4	1.3	0.6	0.9
Average weekly beer plus cider intake	1.2	1.7	4.0	-2.0	-1.2	-1.1	1.2	-1.0	-1.0	-1.3
Medication: Omeprazole (e.g. Zanprol)	1.2	1.4	3.7	1.9	1.8	0.0	-1.6	0.2	0.2	0.5
Alcohol drinker status: Previous	1.2	1.3	2.0	-1.2	0.8	0.9	-0.8	1.4	1.3	1.4
Depressed Affect (Nagel 2018)	1.1	2.3	3.0	-1.7	-1.0	-1.5	1.4	-1.4	-1.7	-1.7
Alzheimer’s Disease (in father)	1.1	1.2	5.3	-2.3	-0.2	0.6	1.2	0.7	0.4	0.8
Fasting Glucose	1.1	1.4	4.5	1.6	0.9	0.1	-2.1	-1.2	-0.0	-0.6
HbA1C	1.1	1.2	3.9	1.4	-0.6	0.0	-2.0	0.0	-1.0	-1.0
Fed-up feelings	1.1	2.0	3.5	-1.9	-0.9	-1.7	1.1	-0.8	-1.8	-1.2
Frequency of unenthusiasm / disinterest in last 2 weeks	1.1	1.4	5.0	-1.9	-0.6	-0.6	2.2	-0.2	-0.7	-0.2
Chronic bronchitis/emphysema (father)	1.1	1.2	2.5	-0.6	-0.7	-1.6	-0.9	-1.1	-1.2	-1.4
Medication: Simvastatin	1.1	1.6	3.8	1.1	1.9	1.3	-1.7	0.5	0.9	0.9
Neuroticism score	1.1	2.4	4.5	-2.1	-1.1	-1.6	2.0	-0.7	-1.6	-1.1
Hip circumference	1.1	4.8	29.8	0.7	1.6	-0.2	-5.5	0.3	0.3	0.6
Alcohol intake versus 10 years previously	1.1	1.7	3.6	1.6	1.3	1.3	-1.2	0.4	1.9	0.9
Mouth/teeth dental problems: Dentures	1.1	1.9	4.4	0.0	1.3	1.2	-2.1	1.6	0.9	1.6
Medication: Cholesterol lowering	1.1	1.7	3.8	0.3	2.0	1.4	-1.6	0.7	1.0	1.4
Medication: Paracetamol	1.1	1.8	7.0	0.7	1.6	0.3	-2.6	1.1	0.3	1.1
Medication: Omeprazole	1.1	1.3	3.6	1.8	1.4	-0.4	-1.9	0.1	-0.2	0.4
Suffer from ‘nerves’	1.1	1.8	5.5	-2.2	-0.6	-0.3	2.4	-0.7	-0.7	-0.7
Chest pain or discomfort	1.1	1.5	4.2	-1.3	0.3	1.1	2.0	1.3	0.9	1.1
Asthma (self-reported)	1.1	2.3	11.3	-1.1	-0.1	1.2	3.4	1.1	0.5	0.8
Medication: Gliclazide	1.1	1.2	2.7	-0.7	0.7	1.1	-0.0	1.6	1.0	1.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.1	2.4	5.6	0.5	-0.3	-1.7	-1.5	-2.4	-1.4	-1.9
Miserableness	1.1	2.0	7.0	-2.6	-0.1	-0.9	1.7	-0.9	-1.0	-1.1
Unable to work because of sickness or disability	1.1	1.5	5.7	1.1	1.7	0.2	-2.4	-0.2	0.5	0.4
Pack years of smoking	1.1	1.6	5.9	1.8	0.1	-0.6	-2.4	-0.9	-0.6	-0.5
Ulcerative Colitis (UC)	1.0	1.9	9.7	1.3	0.3	0.0	-3.1	-0.2	-1.2	-0.3
Diabetes (mother)	1.0	1.3	5.0	0.9	0.5	-1.1	-2.2	-0.8	-0.9	-0.7
Average weekly fortified wine intake	1.0	1.2	2.4	0.8	1.5	1.1	1.0	1.1	0.8	1.1
Serious illness, injury or assault of a close relative in last 2 years	1.0	1.1	7.3	-0.4	-0.3	0.4	2.7	0.1	0.3	-0.2
Blood clot in the leg (DVT)	1.0	1.3	2.7	0.4	1.3	0.9	-1.6	1.1	0.9	1.4
Heart disease (mother)	1.0	1.2	3.1	0.9	0.0	-1.3	-1.8	-1.0	-0.9	-1.0
Long-standing illness, disability or infirmity	1.0	1.5	3.3	-1.2	-1.2	-1.6	0.7	-0.3	-1.8	-0.8
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.0	1.2	2.6	-0.4	0.9	1.1	-0.7	1.6	0.8	1.6
Medication: Blood pressure	1.0	1.9	4.4	-0.2	2.1	1.2	-2.0	0.4	1.3	1.1
High cholesterol (Self-reported)	1.0	1.8	3.5	0.1	1.9	1.5	-1.8	0.8	1.2	1.3
Heart attack/myocardial infarction (self-reported)	1.0	1.2	3.1	0.4	1.8	1.0	-0.6	1.1	1.1	1.2
Deep venous thrombosis (DVT) (self-reported)	1.0	1.2	3.3	0.3	1.2	0.8	-1.8	1.0	0.8	1.3
Mean Putamen Volume	0.9	1.0	2.1	1.2	1.2	0.0	-0.5	0.0	1.4	1.5
Schizophrenia (2014)	0.9	1.9	8.2	-1.2	-1.3	0.0	2.9	0.0	-0.8	-1.0
Triglycerides	0.9	1.5	8.0	1.3	0.8	0.0	-2.8	0.0	-0.4	0.2
Average weekly spirits intake	0.9	1.1	2.2	1.1	0.6	-1.1	-1.5	-0.9	-1.2	-0.7
Forced vital capacity (FVC)	0.9	3.6	10.3	-3.2	-1.3	-0.7	2.9	-1.4	-0.7	-1.5
Allergy	0.9	2.1	10.3	1.7	1.1	-0.1	-3.2	-0.4	-0.1	0.0
Falls in the last year	0.9	1.2	4.3	-2.1	0.9	-0.1	-0.5	1.3	0.2	1.0
Seen doctor (GP) for nerves, anxiety, tension or depression	0.9	1.4	3.9	-2.0	-1.4	-0.9	1.1	-0.5	-0.7	-0.8
Health satisfaction	0.9	1.2	2.3	1.3	0.8	0.3	-1.4	1.5	0.3	1.3
Shortness of breath walking on level ground	0.9	1.0	1.8	-1.3	-1.4	-1.2	-0.0	-0.4	-1.3	-0.7
Eye problems/disorders: None of the above	0.9	1.0	2.3	-0.4	0.1	1.0	1.5	1.0	1.4	0.9
Neck or shoulder pain in last month	0.9	1.3	5.1	0.3	0.8	0.3	-2.2	1.1	0.6	1.2
Mood swings	0.9	1.6	2.3	-0.8	-0.6	-1.1	1.3	-1.5	-1.5	-1.5
Medication: Atorvastatin	0.9	1.1	3.8	-1.9	-0.2	-0.4	-2.0	0.2	-0.6	0.2
Diastolic blood pressure, automated reading	0.9	2.6	11.3	1.3	1.2	0.5	-3.4	1.1	0.7	1.4
Bipolar Disorder or Schizophrenia	0.8	1.9	11.6	-0.8	-1.1	0.0	3.4	0.0	0.1	-0.3
Worry (Nagel 2018)	0.8	1.8	3.1	-1.3	-1.6	-1.2	1.8	-0.6	-1.4	-1.0
HDL Cholesterol	0.8	1.3	5.0	-0.0	0.4	0.0	0.4	0.0	2.2	1.9
Hypothyroidism (self reported)	0.8	1.8	4.2	-1.8	0.3	1.6	2.1	0.5	1.6	0.5
Impedance of leg (left)	0.8	3.9	16.9	-1.3	-1.7	-0.9	4.1	-1.1	-0.8	-1.7
Leg predicted mass (left)	0.8	4.1	22.2	0.6	1.4	0.4	-4.7	1.1	0.7	1.4
Diabetes (self-reported)	0.8	1.3	2.3	0.5	1.0	0.9	-1.5	1.5	0.5	1.4
Happiness	0.8	0.9	2.2	-1.5	-0.7	-1.0	1.2	-0.3	-1.0	-0.6
Medication: Ibuprofen (e.g. Nurofen)	0.8	1.0	1.7	1.3	-1.3	-0.9	-0.0	-0.4	-1.1	-1.0
Peak expiratory flow (PEF)	0.8	1.9	6.2	-2.5	0.3	1.3	1.7	0.5	1.3	0.4
Medication for cholesterol, blood pressure or diabetes	0.8	1.4	4.9	-1.4	-1.4	-0.5	2.2	-0.0	-0.3	-0.6
Medication: Amlodipine	0.8	1.1	5.5	-0.2	-0.7	-0.5	-2.3	-0.5	-1.0	-0.3
Forced vital capacity (FVC), Best measure	0.8	3.0	12.1	-3.5	-1.3	-0.5	2.2	-0.9	-0.3	-1.0
Commuting to job workplace: Walk	0.8	0.8	2.7	-1.0	1.0	0.6	1.6	0.7	0.2	0.4
Breast cancer (self-reported)	0.8	1.0	3.1	1.4	0.7	-0.6	-1.8	-0.6	-0.5	-0.5
Ever taken oral contraceptive pill	0.8	0.9	4.0	-0.8	-0.7	0.8	2.0	0.7	0.2	0.4
Fractured/broken bones in last 5 years	0.8	1.0	2.2	-1.5	0.1	0.9	1.2	1.1	0.5	0.9
Age started oral contraceptive pill	0.8	1.0	5.3	2.3	0.5	0.1	-0.8	-0.9	-0.2	-0.4
Heart disease (siblings)	0.8	0.9	3.2	0.2	0.3	-1.0	-1.8	-0.9	-0.7	-0.9
Impedance of whole body	0.8	4.0	23.6	-0.7	-1.6	-0.2	4.9	-0.2	-0.2	-1.0
Bipolar Disorder (2018)	0.7	1.1	6.6	-0.4	-0.6	0.0	2.6	0.0	0.7	0.2
Smoking Status	0.7	1.6	3.2	-1.1	0.6	0.9	-1.8	1.4	0.5	1.7
Cardiovascular Disease	0.7	2.3	8.6	0.7	1.8	1.0	-2.9	0.8	0.7	1.4
Supplements: Zinc	0.7	0.7	1.8	-0.9	-1.0	0.2	1.4	0.8	0.5	0.7
Impedance of leg (right)	0.7	3.3	16.0	-0.3	-1.8	-0.8	4.0	-0.9	-0.7	-1.4
Leg fat-free mass (left)	0.7	4.0	22.0	0.6	1.3	0.4	-4.7	1.1	0.6	1.4
Hand grip strength (right)	0.7	2.0	4.1	-0.1	2.0	1.0	-1.9	1.4	1.1	1.5
Relative age voice broke	0.7	1.0	1.7	0.7	1.1	1.3	0.6	1.1	0.8	1.3
Qualifications: CSEs or equivalent	0.7	0.9	3.9	-0.1	-0.4	0.1	-2.0	1.1	0.5	0.9
Stomach or abdominal pain in last month	0.7	0.8	2.2	0.1	0.9	0.4	0.9	1.5	0.6	1.2
Nervous feelings	0.7	1.3	2.2	0.0	-1.2	-1.3	1.5	-1.0	-1.2	-1.2
Impedance of arm (right)	0.7	3.3	20.1	0.2	-0.8	1.0	4.5	0.8	0.8	0.1
Hair/balding pattern: Pattern 3	0.7	1.0	2.0	0.5	-1.2	-1.4	-0.3	-0.9	-1.1	-1.2
Impedance of arm (left)	0.7	3.4	22.2	-0.0	-1.0	0.6	4.7	0.5	0.4	-0.2
Gout (self-reported)	0.7	1.0	3.3	-1.8	0.7	0.6	1.2	1.0	0.5	0.6
Number of full brothers	0.7	0.8	1.6	0.5	0.9	1.0	0.1	1.0	1.0	1.2
Medication: Blood pressure	0.7	1.2	3.2	0.6	0.4	-1.1	-1.8	-1.1	-1.2	-0.9
Family relationship satisfaction	0.7	0.9	4.0	-1.1	-0.5	-0.6	2.0	-0.3	-0.3	-0.6
Leg pain on walking	0.7	0.8	2.5	1.2	-1.6	-0.8	0.5	-0.3	-0.8	-0.6
Smoking status: Previous	0.7	1.0	4.6	1.2	0.9	0.4	-2.2	-0.5	-0.3	0.2
Handedness (chirality/laterality): Left-handed	0.7	0.8	4.0	2.0	0.7	0.4	-0.9	0.3	0.2	0.5
Arm fat-free mass (left)	0.7	3.5	20.7	0.3	1.5	0.3	-4.5	0.6	0.6	1.1
Pain experienced in last month	0.7	1.1	2.2	1.3	0.1	1.5	0.8	0.8	1.2	0.9
Arm predicted mass (left)	0.7	3.6	21.3	0.4	1.4	0.2	-4.6	0.6	0.5	1.1
Type 2 Diabetes (T2D) (2012)	0.6	0.7	2.6	-1.1	-0.5	0.0	-0.9	0.0	-1.6	0.0
Respiratory disease	0.6	1.4	8.1	-0.3	-0.3	1.0	2.9	0.5	0.5	0.4
Systolic blood pressure, automated reading	0.6	1.6	8.2	0.8	0.1	-1.2	-2.9	-0.5	-0.9	-0.2
Medication for hormone replacement therapy	0.6	0.6	1.0	0.8	-0.8	0.7	-0.6	1.0	0.5	1.0
Medication: Co-codamol	0.6	0.7	1.2	0.5	0.3	0.8	-0.9	1.1	0.9	1.0
Age when periods started (menarche)	0.6	1.4	4.8	0.6	1.0	1.0	2.2	0.9	1.1	0.7
Tinnitus: Yes, but not now, but have in the past	0.6	0.7	2.6	0.6	-0.4	-0.4	-1.6	-1.1	-0.2	-0.4
Medication: Atenolol	0.6	0.8	2.9	0.9	1.2	-0.0	-1.7	0.3	0.2	0.2
Hair/balding pattern: Pattern 2	0.6	0.7	1.7	1.0	-0.8	-1.3	-0.6	-0.3	-1.1	-0.4
Financial difficulties in last 2 years	0.6	0.9	3.1	0.6	0.5	-0.6	-1.8	1.0	-0.4	0.8
Forced expiratory volume in 1-second (FEV1)	0.6	2.1	8.0	-2.8	-0.9	-0.0	2.0	-0.8	-0.1	-0.9
Mouth/teeth dental problems: Bleeding gums	0.6	0.8	3.2	-1.0	-0.9	-0.5	1.8	-0.1	-0.3	-0.5
Glaucoma (self-reported)	0.6	0.8	1.7	0.6	1.3	1.2	-0.1	0.4	1.2	0.6
Hypothyroidism/myxoedema (self-reported)	0.6	1.1	3.9	-1.0	-0.0	1.0	2.0	0.4	1.3	0.3
Age at first live birth	0.6	1.0	3.7	0.0	0.3	1.0	1.9	0.3	1.4	0.3
Qualifications: NVQ or HND or HNC or equivalent	0.6	0.8	1.9	-0.2	-1.1	-0.7	-1.4	-0.7	-1.1	-0.3
Medication: Aspirin	0.6	0.7	1.4	0.5	1.1	1.1	-1.2	-0.1	0.9	0.7
Leg fat-free mass (right)	0.6	3.5	18.0	0.0	1.4	0.5	-4.2	1.2	0.7	1.4
Medication for cholesterol	0.6	1.0	4.2	0.2	-0.6	-1.1	2.0	-0.1	-0.7	-0.6
Leg predicted mass (right)	0.6	3.4	18.1	0.1	1.4	0.5	-4.3	1.2	0.6	1.4
Eye problems/disorders: Glaucoma	0.6	0.8	1.6	0.1	1.2	1.1	-0.3	0.7	1.3	0.8
Basal metabolic rate	0.6	3.5	19.9	0.4	1.3	0.4	-4.5	1.0	0.6	1.3
Supplements: Calcium	0.6	0.7	1.9	-1.2	-0.9	0.7	1.4	0.1	0.4	0.2
Schizophrenia (2018)	0.5	1.0	5.4	-0.7	-0.8	0.0	2.3	0.0	-0.4	-0.5
Alzheimer’s Disease (in mother)	0.5	0.6	1.6	-0.8	-1.0	-0.8	1.3	0.0	-0.2	-0.6
Alzheimer’s Disease (including proxy)	0.5	0.7	2.1	-1.4	-0.7	-0.4	1.4	0.4	0.0	-0.0
Irritable Bowel Disease (IBD)	0.5	1.3	6.9	0.8	-0.0	0.0	-2.6	-0.5	-0.9	-0.5
Neuroticism	0.5	1.1	4.2	-1.3	-0.4	-0.6	2.0	-0.4	-0.8	-0.5
Hearing difficulty/problems: Yes	0.5	0.8	1.4	-1.0	-1.2	-0.8	-0.1	-0.5	-1.1	-0.8
Taking other prescription medications	0.5	0.8	3.9	0.4	1.3	0.1	-2.0	-0.0	0.2	0.3
Heel bone mineral density (BMD) T-score, automated (left)	0.5	1.2	2.3	0.1	0.7	1.5	0.7	1.2	1.4	1.1
Serious illness, injury or assault to yourself	0.5	0.7	2.1	0.2	1.4	0.4	-1.4	0.5	0.2	0.5
Medication: Ramipril	0.5	0.6	1.6	1.0	1.3	0.1	-0.9	0.7	0.1	0.6
Frequency of tiredness / lethargy in last 2 weeks	0.5	0.8	2.6	-1.4	-0.4	-0.4	1.6	0.4	-0.5	-0.1
Prospective memory result	0.5	0.6	1.4	1.1	-0.9	-0.7	-1.2	-0.2	-0.3	-0.3
Forced expiratory volume in 1-second (FEV1), Best measure	0.5	1.4	7.7	-2.8	-0.9	0.0	1.1	-0.5	0.2	-0.5
Pulse wave Arterial Stiffness index	0.5	0.5	1.0	0.1	-0.8	-0.9	-0.6	-0.5	-1.0	-0.7
Arm fat-free mass (right)	0.5	2.5	15.7	-0.2	0.8	-0.0	-4.0	0.7	0.3	0.9
Pulse wave peak to peak time	0.5	0.6	1.0	-0.3	0.7	0.8	1.0	0.5	1.0	0.7
Medication: Seretide 50 evohaler	0.5	0.5	2.4	1.5	-0.4	-0.8	0.4	0.1	-0.5	-0.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.5	0.6	1.1	-0.6	-0.7	-0.8	-0.4	-1.1	-0.6	-1.0
Arm predicted mass (right)	0.5	2.7	16.9	-0.2	0.9	-0.2	-4.1	0.5	0.1	0.8
Diabetes diagnosed by doctor	0.5	0.9	3.1	0.6	0.7	0.3	-1.8	1.0	-0.1	0.9
Eye problems/disorders: Cataract	0.5	0.6	1.2	1.0	0.5	-0.5	-1.1	-0.8	-0.6	-0.6
Osteoporosis (self-reported)	0.5	0.6	1.0	1.0	-0.1	-1.0	-0.7	-0.8	-0.8	-0.8
Myopia	0.5	0.7	1.7	0.8	0.7	0.9	0.8	0.6	1.3	0.6
Basal cell carcinoma (self-reported)	0.5	0.6	2.7	-0.5	-1.6	-0.2	0.6	-0.2	-0.5	-0.5
Reaction Time	0.4	0.7	2.1	1.4	0.3	-0.5	-0.2	-0.9	-1.0	-0.8
Ovarian Cancer	0.4	0.5	1.1	-1.0	0.2	0.6	0.4	0.9	0.5	0.8
Coronary Artery Disease (CAD)	0.4	0.5	1.9	1.2	1.4	0.0	0.0	0.0	0.0	0.0
Neuroticism (2016)	0.4	0.6	3.2	-0.5	-0.5	0.0	1.8	0.5	0.5	0.3
Lung FEV1/FVC ratio	0.4	1.9	10.2	1.4	0.5	-0.0	-3.2	0.5	-0.1	0.7
Ever had hysterectomy (womb removed)	0.4	0.5	0.8	0.5	-0.6	-0.9	-0.8	-0.3	-0.9	-0.4
Alcohol usually taken with meals	0.4	0.6	1.5	0.2	-0.7	0.6	1.2	1.0	0.6	0.7
Mouth/teeth dental problems	0.4	0.6	1.8	0.1	0.3	1.2	0.5	0.4	1.3	0.6
Pain all over the body in last month	0.4	0.4	1.8	0.1	1.3	0.6	-0.1	-0.4	0.6	0.2
Breastfed as a baby	0.4	0.6	1.4	-0.1	1.2	0.7	0.7	0.7	0.7	0.8
Pulse wave reflection index	0.4	0.5	1.1	-0.6	-0.4	-0.5	-0.1	-0.9	-1.0	-0.8
Ever highly irritable/argumentative for 2 days	0.4	0.4	2.0	0.9	0.2	-0.1	-1.4	-0.3	-0.2	-0.1
Headache pain in last month	0.4	0.8	1.4	-0.6	1.1	0.3	-0.9	1.2	0.6	0.9
Medication for pain relief, constipation, heartburn	0.4	0.7	3.2	-0.9	-0.9	0.0	1.8	-0.3	-0.0	-0.3
Comparative height size at age 10	0.4	2.4	4.1	-1.0	-1.5	-1.6	-0.0	-2.0	-1.6	-2.0
Overall health rating	0.4	0.8	4.2	0.6	0.6	-0.6	-2.0	-0.2	-0.3	-0.0
Hypertension (Self-reported)	0.4	1.0	3.6	-0.2	1.9	0.6	-1.7	0.0	0.2	0.4
Illnesses of siblings: Diabetes	0.4	0.5	1.0	1.0	-0.0	-0.9	-1.0	-0.2	-0.8	-0.5
Whole body fat-free mass	0.4	2.4	12.1	0.0	1.0	0.5	-3.5	1.1	0.7	1.3
Ever had bowel cancer screening	0.4	0.5	2.6	-0.5	-0.8	0.1	1.6	-0.0	0.2	-0.2
Osteoarthritis (self-reported)	0.4	0.5	2.6	1.6	0.3	0.3	-0.5	0.6	0.2	0.3
Medication: Aspirin	0.4	0.6	1.3	0.3	1.2	0.8	-1.1	-0.2	0.5	0.5
Whole body water mass	0.4	2.4	12.4	0.1	1.1	0.5	-3.5	1.0	0.7	1.3
Average weekly champagne plus white wine intake	0.4	0.6	2.5	-0.4	-1.0	0.1	1.6	0.7	0.2	0.2
Wears glasses or contact lenses	0.4	0.5	0.7	-0.8	0.3	-0.8	-0.9	-0.7	-0.3	-0.7
Illnesses of father: High blood pressure	0.4	0.5	1.1	1.1	-0.1	0.4	0.6	1.0	0.4	0.7
Cholesterol lowering medication	0.4	0.5	2.2	-1.5	0.3	0.1	-1.2	0.0	0.1	-0.1
Breast Cancer	0.3	0.8	3.7	0.6	0.6	0.7	1.9	0.8	0.3	0.5
Prostate Cancer	0.3	0.4	0.9	-0.3	-0.6	0.7	0.9	0.9	0.3	0.6
Rheumatoid Arthritis	0.3	0.4	1.9	1.4	0.1	0.0	-0.7	0.0	0.6	0.6
Blood Eosinophil Count	0.3	2.5	3.6	-1.6	-1.8	-1.4	1.9	-1.4	-1.4	-1.4
Systolic Blood Pressure	0.3	1.3	7.1	-0.3	-0.5	-1.1	-2.7	-0.3	-0.8	-0.1
Sensitivity / hurt feelings	0.3	0.5	1.4	-0.8	0.1	-1.2	0.3	-0.1	-0.9	-0.4
Relative age of first facial hair	0.3	0.6	3.1	1.8	0.7	0.1	0.5	0.6	0.1	0.5
Diabetes (father)	0.3	0.4	0.6	-0.7	0.7	0.5	-0.5	0.6	0.5	0.8
Severe depression (siblings)	0.3	0.3	0.9	0.1	-0.5	0.4	1.0	0.7	0.2	0.6
Bilateral oophorectomy (both ovaries removed)	0.3	0.3	1.4	1.2	-0.1	-0.3	-0.7	0.2	-0.3	0.2
High blood pressure	0.3	0.9	3.4	-0.3	1.8	0.7	-1.4	0.2	0.3	0.6
Diverticular disease/diverticulitis (self-reported)	0.3	0.3	1.6	-1.2	-0.1	-0.2	0.4	-0.6	-0.1	-0.3
Past tobacco smoking	0.3	0.6	3.1	-0.0	-0.7	-0.7	1.7	0.0	0.0	-0.5
Hearing difficulty/problems with background noise	0.3	0.5	1.5	1.1	-0.2	-0.4	-1.2	0.1	-0.5	-0.0
Lung cancer (father)	0.3	0.4	0.8	0.0	-0.2	0.9	-0.3	0.7	0.8	0.9
Standing height	0.3	2.6	8.9	-2.3	-1.4	0.5	3.0	1.1	0.5	0.4
Birth weight of first child	0.3	0.5	1.4	-0.4	0.8	1.2	0.4	0.7	0.8	0.6
Emphysema/chronic bronchitis	0.3	0.3	1.2	-0.2	0.1	-0.3	-1.1	-0.6	-0.4	-0.3
Medication: Ibuprofen	0.3	0.4	0.9	1.0	-0.4	-0.4	-0.2	-0.3	-0.8	-0.7
Mean time to correctly identify matches	0.3	0.5	1.7	1.3	0.5	-0.1	0.3	-0.8	-0.5	-0.6
Age at last live birth	0.3	0.5	2.7	-0.3	-0.5	-0.1	1.6	-0.2	0.0	-0.4
Commuting to job workplace: Car/motor vehicle	0.3	0.4	0.5	-0.6	-0.4	-0.7	-0.6	-0.7	-0.7	-0.6
Illnesses of father: Heart disease	0.3	0.5	1.2	0.1	1.1	-0.6	-0.4	-0.6	-0.7	-0.7
Forced expiratory volume in 1-second (FEV1), predicted	0.3	0.6	1.9	-1.2	-0.8	0.2	1.4	0.3	0.5	0.1
Illnesses of father: None of the above (group 1)	0.3	0.4	1.4	0.4	-0.1	0.5	-1.2	-0.7	0.7	-0.2
Guilty feelings	0.3	0.4	1.7	-1.1	-0.1	-0.1	1.3	-0.2	0.1	-0.3
Financial situation satisfaction	0.3	0.4	1.3	0.4	-0.6	-0.7	-1.1	0.6	-0.5	0.3
Medication: Bendroflumethiazide	0.3	0.4	1.3	0.5	1.1	0.2	-0.9	0.1	0.4	0.5
Ever depressed for a whole week	0.3	0.4	1.3	0.5	0.1	0.1	-1.1	0.8	-0.0	0.5
Vascular/heart problems diagnosed by doctor	0.3	0.9	3.5	0.3	-1.9	-0.9	1.1	-0.2	-0.5	-0.7
Major Depression (MDD)	0.2	0.2	0.6	-0.5	0.7	0.0	0.8	0.0	0.3	0.2
Bipolar Disorder (2011)	0.2	0.2	1.3	-1.1	0.0	0.0	0.0	0.0	0.0	0.0
Lupus	0.2	0.2	1.0	0.3	-0.2	-0.5	0.1	1.0	-0.2	0.6
Heel T-Score	0.2	1.7	4.2	0.3	2.1	1.6	0.8	0.8	1.4	1.2
Height	0.2	4.0	10.2	-3.1	-1.9	-0.8	3.2	-0.9	-0.9	-1.4
Lung FVC	0.2	1.2	2.8	-0.3	-0.7	-1.1	1.7	-1.2	-0.9	-1.3
Eye problems/disorders: Diabetes related eye disease	0.2	0.3	0.7	-0.9	0.4	-0.1	-0.7	0.2	-0.4	0.3
Townsend deprivation index at recruitment	0.2	0.3	1.0	0.4	0.4	-0.6	-1.0	-0.6	-0.4	-0.3
Sitting height	0.2	1.6	5.8	-1.7	-1.3	0.3	2.4	0.7	0.1	0.2
Had menopause	0.2	0.2	0.7	0.3	-0.4	-0.2	0.2	-0.9	-0.2	-0.7
Had other major operations	0.2	0.2	0.9	0.3	0.2	0.3	-1.0	0.4	0.4	0.5
Ever unenthusiastic/disinterested for a whole week	0.2	0.2	0.4	0.6	0.7	0.4	-0.3	0.4	0.1	0.4
Trunk fat-free mass	0.2	1.0	4.9	-0.3	0.5	0.4	-2.2	0.8	0.5	1.0
Worrier / anxious feelings	0.2	0.3	1.1	-0.9	-0.5	-0.5	1.1	-0.0	-0.2	-0.1
Number of live births	0.2	0.3	0.7	-0.4	0.8	0.0	0.3	0.9	-0.3	0.5
Trunk predicted mass	0.2	1.1	5.1	-0.2	0.5	0.5	-2.2	0.9	0.7	1.1
Hair/balding pattern: Pattern 4	0.2	0.5	1.1	-0.9	0.8	0.7	1.1	0.2	0.7	0.2
Loud music exposure frequency	0.2	0.2	0.8	0.6	-0.2	-0.0	0.4	-0.9	-0.2	-0.6
Birth weight	0.2	0.5	1.6	-0.4	0.4	-0.3	-1.3	-0.8	-0.7	-0.6
Wheeze or whistling in the chest in last year	0.2	0.4	1.4	-0.1	-1.2	-0.6	0.4	0.4	-0.7	0.2
Medication: Allopurinol	0.2	0.2	1.6	-1.3	0.3	0.2	0.1	-0.2	0.1	-0.0
Alcohol intake frequency.	0.2	0.5	1.2	-0.8	-0.4	-1.1	-1.0	0.0	-0.4	-0.5
Mouth/teeth dental problems: Mouth ulcers	0.2	0.4	1.7	0.8	-0.1	-0.3	1.3	0.1	-0.5	-0.2
Smoking status: Current	0.2	0.3	1.2	-1.1	-0.2	0.0	0.1	0.7	0.3	0.6
Number of self-reported non-cancer illnesses	0.2	0.3	1.1	0.7	0.2	0.1	-1.0	0.4	0.2	0.3
Hearing aid user	0.2	0.3	0.7	-0.8	0.3	-0.3	0.1	0.8	-0.4	0.2
Medication: Lisinopril	0.2	0.3	1.2	-0.6	0.2	0.2	-1.1	-0.5	0.0	0.0
Alcohol drinker status: Never	0.2	0.3	0.7	-0.8	0.2	0.6	0.8	0.5	0.1	0.2
Ever smoked	0.2	0.4	1.1	-0.6	0.9	1.1	-0.5	-0.0	0.4	0.6
Schizophrenia vs Biploar Disorder	0.1	0.1	0.9	-1.0	-0.1	0.0	0.0	0.0	0.0	0.0
Crohns Disease (2017)	0.1	0.2	0.7	0.1	0.5	0.0	-0.8	0.2	0.8	0.4
Crohns Disease (2012)	0.1	0.1	0.4	-0.3	0.5	0.0	-0.6	0.0	0.5	0.0
Blood Platelet Count	0.1	1.7	2.6	-1.0	1.0	1.6	1.1	1.2	1.5	1.4
Blood Red Count	0.1	0.9	1.9	-0.1	-0.5	0.9	1.2	1.4	0.8	1.0
Blood White Count	0.1	0.9	2.7	1.6	0.7	0.5	-1.2	0.7	0.4	0.8
Tanning	0.1	0.8	1.8	-0.4	-1.3	-0.2	1.3	-0.7	-0.7	-0.8
Hand grip strength (left)	0.1	0.2	1.0	0.2	0.1	-0.4	-1.0	0.1	-0.2	0.1
Other serious medical condition/disability diagnosed by doctor	0.1	0.1	0.3	0.0	0.4	0.3	0.3	0.5	0.4	0.4
Current tobacco smoking	0.1	0.1	0.3	-0.1	0.0	-0.1	-0.6	0.6	0.1	0.5
Medication: Levothyroxine sodium	0.1	0.1	0.4	0.1	-0.3	-0.0	0.6	0.1	0.4	-0.2
Frequency of tenseness / restlessness in last 2 weeks	0.1	0.2	0.5	-0.1	-0.4	-0.5	0.5	-0.1	-0.7	0.0
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.2	0.8	-0.1	-0.4	0.4	0.9	0.4	0.3	0.2
Time employed in main current job	0.1	0.1	0.6	-0.3	-0.0	0.1	0.2	-0.8	-0.0	-0.3
Pulse rate	0.1	0.1	0.5	0.3	0.0	-0.1	-0.5	0.7	0.0	0.3
Pulse rate, automated reading	0.1	0.4	2.6	-0.2	0.4	-0.4	-1.6	-0.1	-0.3	0.3
Illness, injury, bereavement, stress in last 2 years	0.1	0.2	0.5	-0.1	-0.7	-0.3	-0.6	-0.3	-0.2	-0.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.1	0.1	0.3	0.5	0.1	-0.2	0.6	-0.1	-0.1	-0.2
Loneliness, isolation	0.1	0.1	0.3	0.3	0.1	0.2	0.5	0.2	0.2	0.2
Back pain experienced in last month	0.1	0.2	0.4	-0.6	-0.2	-0.5	-0.5	0.4	-0.4	0.1
Risk taking	0.1	0.1	0.3	0.6	0.1	0.4	0.4	0.4	0.0	0.1
Ever had prostate specific antigen (PSA) test	0.1	0.1	0.4	0.0	0.6	0.1	0.4	0.2	0.4	0.2
Hair Pigment	0.0	0.7	1.8	0.7	0.2	0.6	0.1	1.4	0.9	1.2
Average weekly red wine intake	0.0	0.1	0.2	0.4	-0.3	-0.1	-0.3	-0.1	-0.2	-0.1

Hub : Genes

MRM1

Models

Trait associations