Hub : Genes

MRM1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Artery Tibial	0.1038	0.0442	4.5e-03	0.040	NA	-0.003	NA	0.010	0.00044	NA	0.65000	NA	0.05400
2	GTEx	Cells Transformed fibroblasts	0.1770	0.0500	1.7e-05	0.021	NA	0.035	NA	0.031	0.00980	NA	0.00110	NA	0.00230
3	TCGA	Bladder Urothelial Carcinoma	0.0470	0.0270	6.9e-03	0.016	0.003	0.014	NA	0.014	0.01400	1.6e-01	0.02200	NA	0.02100
4	TCGA	Colon Adenocarcinoma	0.0580	0.0320	3.7e-03	0.056	0.038	0.048	NA	0.047	0.00037	2.9e-03	0.00094	NA	0.00098
5	TCGA	Head and Neck Squamous Cell Carcinoma	0.0395	0.0226	3.4e-03	0.009	0.002	0.019	NA	0.014	0.02900	1.6e-01	0.00290	NA	0.00940
6	TCGA	Kidney Renal Clear Cell Carcinoma	0.0348	0.0186	3.3e-03	0.018	0.006	0.028	NA	0.025	0.00320	6.9e-02	0.00038	NA	0.00067
7	TCGA	Brain Lower Grade Glioma	0.0422	0.0206	4.8e-04	0.027	0.039	0.032	NA	0.030	0.00047	2.5e-05	0.00014	NA	0.00023

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Bipolar Disorder (2018)	0.7	1.1	6.6	-0.4	-0.6	0.0	2.6	0.0	0.7	0.2
Bipolar Disorder or Schizophrenia	0.8	1.9	11.6	-0.8	-1.1	0.0	3.4	0.0	0.1	-0.3
Depressed Affect (Nagel 2018)	1.1	2.3	3.0	-1.7	-1.0	-1.5	1.4	-1.4	-1.7	-1.7
Depression (Nagel 2018)	2.4	3.7	9.3	-2.8	-1.8	-0.8	3.0	-0.9	-1.3	-1.4
Intelligence (Savage-Jansen 2018)	2.6	7.9	31.2	-3.2	-2.5	-1.2	5.6	-0.7	-1.4	-1.9
Neuroticism (Nagel 2018)	1.2	2.9	4.2	-1.6	-1.8	-1.6	2.1	-1.2	-1.8	-1.6
Schizophrenia (2018)	0.5	1.0	5.4	-0.7	-0.8	0.0	2.3	0.0	-0.4	-0.5
Schizophrenia vs Biploar Disorder	0.1	0.1	0.9	-1.0	-0.1	0.0	0.0	0.0	0.0	0.0
Worry (Nagel 2018)	0.8	1.8	3.1	-1.3	-1.6	-1.2	1.8	-0.6	-1.4	-1.0
Alzheimer’s Disease (in mother)	0.5	0.6	1.6	-0.8	-1.0	-0.8	1.3	0.0	-0.2	-0.6
Alzheimer’s Disease (in father)	1.1	1.2	5.3	-2.3	-0.2	0.6	1.2	0.7	0.4	0.8
Alzheimer’s Disease (including proxy)	0.5	0.7	2.1	-1.4	-0.7	-0.4	1.4	0.4	0.0	-0.0
Crohns Disease (2017)	0.1	0.2	0.7	0.1	0.5	0.0	-0.8	0.2	0.8	0.4
Irritable Bowel Disease (IBD)	0.5	1.3	6.9	0.8	-0.0	0.0	-2.6	-0.5	-0.9	-0.5
Ulcerative Colitis (UC)	1.0	1.9	9.7	1.3	0.3	0.0	-3.1	-0.2	-1.2	-0.3
Major Depression (MDD)	0.2	0.2	0.6	-0.5	0.7	0.0	0.8	0.0	0.3	0.2
Reaction Time	0.4	0.7	2.1	1.4	0.3	-0.5	-0.2	-0.9	-1.0	-0.8
Verbal and Numeric Reasoning (VNR)	4.2	10.0	30.2	-4.1	-2.6	-1.5	5.5	-2.0	-1.8	-2.7
Breast Cancer	0.3	0.8	3.7	0.6	0.6	0.7	1.9	0.8	0.3	0.5
Ovarian Cancer	0.4	0.5	1.1	-1.0	0.2	0.6	0.4	0.9	0.5	0.8
Prostate Cancer	0.3	0.4	0.9	-0.3	-0.6	0.7	0.9	0.9	0.3	0.6
Age at First Birth	1.8	2.6	5.9	0.7	0.5	2.0	0.7	2.4	1.5	2.2
Bipolar Disorder (2011)	0.2	0.2	1.3	-1.1	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	2.7	3.7	15.4	1.8	2.4	0.0	-3.9	0.0	0.6	1.2
Coronary Artery Disease (CAD)	0.4	0.5	1.9	1.2	1.4	0.0	0.0	0.0	0.0	0.0
Crohns Disease (2012)	0.1	0.1	0.4	-0.3	0.5	0.0	-0.6	0.0	0.5	0.0
Mean Putamen Volume	0.9	1.0	2.1	1.2	1.2	0.0	-0.5	0.0	1.4	1.5
Fasting Glucose	1.1	1.4	4.5	1.6	0.9	0.1	-2.1	-1.2	-0.0	-0.6
HbA1C	1.1	1.2	3.9	1.4	-0.6	0.0	-2.0	0.0	-1.0	-1.0
HDL Cholesterol	0.8	1.3	5.0	-0.0	0.4	0.0	0.4	0.0	2.2	1.9
LDL Cholesterol	1.3	2.0	5.4	1.0	2.3	0.0	-1.8	0.0	1.4	1.6
Lupus	0.2	0.2	1.0	0.3	-0.2	-0.5	0.1	1.0	-0.2	0.6
Neuroticism (2016)	0.4	0.6	3.2	-0.5	-0.5	0.0	1.8	0.5	0.5	0.3
Primary Biliary Cirrhosis	1.8	2.6	8.9	2.6	1.6	0.0	-3.0	0.0	0.0	0.0
Rheumatoid Arthritis	0.3	0.4	1.9	1.4	0.1	0.0	-0.7	0.0	0.6	0.6
Schizophrenia (2014)	0.9	1.9	8.2	-1.2	-1.3	0.0	2.9	0.0	-0.8	-1.0
Triglycerides	0.9	1.5	8.0	1.3	0.8	0.0	-2.8	0.0	-0.4	0.2
Type 2 Diabetes (T2D) (2012)	0.6	0.7	2.6	-1.1	-0.5	0.0	-0.9	0.0	-1.6	0.0
Ulcerative Colitis	1.3	1.9	5.5	0.6	0.2	0.0	-2.3	0.0	-2.1	-1.8
Blood Eosinophil Count	0.3	2.5	3.6	-1.6	-1.8	-1.4	1.9	-1.4	-1.4	-1.4
Blood Platelet Count	0.1	1.7	2.6	-1.0	1.0	1.6	1.1	1.2	1.5	1.4
Blood Red Count	0.1	0.9	1.9	-0.1	-0.5	0.9	1.2	1.4	0.8	1.0
Blood White Count	0.1	0.9	2.7	1.6	0.7	0.5	-1.2	0.7	0.4	0.8
Heel T-Score	0.2	1.7	4.2	0.3	2.1	1.6	0.8	0.8	1.4	1.2
BMI	2.2	12.8	67.9	3.1	3.0	0.2	-8.2	0.4	1.0	1.4
Height	0.2	4.0	10.2	-3.1	-1.9	-0.8	3.2	-0.9	-0.9	-1.4
Waist Hip Ratio (WHR)	1.6	7.1	10.0	3.1	2.4	1.7	-3.2	3.0	1.7	3.1
Systolic Blood Pressure	0.3	1.3	7.1	-0.3	-0.5	-1.1	-2.7	-0.3	-0.8	-0.1
Smoking Status	0.7	1.6	3.2	-1.1	0.6	0.9	-1.8	1.4	0.5	1.7
Allergy or Eczema	2.0	5.3	20.5	-2.3	-2.9	-0.8	4.5	-0.6	-0.7	-1.2
Cardiovascular Disease	0.7	2.3	8.6	0.7	1.8	1.0	-2.9	0.8	0.7	1.4
Hypothyroidism (self reported)	0.8	1.8	4.2	-1.8	0.3	1.6	2.1	0.5	1.6	0.5
Respiratory disease	0.6	1.4	8.1	-0.3	-0.3	1.0	2.9	0.5	0.5	0.4
Type 2 Diabetes (T2D) (2018)	1.5	2.7	4.7	0.8	2.2	1.5	-1.6	1.7	1.3	2.0
Lung FEV1/FVC ratio	0.4	1.9	10.2	1.4	0.5	-0.0	-3.2	0.5	-0.1	0.7
Lung FVC	0.2	1.2	2.8	-0.3	-0.7	-1.1	1.7	-1.2	-0.9	-1.3
Neuroticism	0.5	1.1	4.2	-1.3	-0.4	-0.6	2.0	-0.4	-0.8	-0.5
Chronotype (morning person)	2.1	4.9	6.4	2.5	2.4	1.9	-2.2	2.2	1.8	2.3
Hair Pigment	0.0	0.7	1.8	0.7	0.2	0.6	0.1	1.4	0.9	1.2
Tanning	0.1	0.8	1.8	-0.4	-1.3	-0.2	1.3	-0.7	-0.7	-0.8
Hand grip strength (left)	0.1	0.2	1.0	0.2	0.1	-0.4	-1.0	0.1	-0.2	0.1
Number of treatments/medications taken	1.5	2.7	8.0	0.9	2.8	1.3	-2.5	0.7	1.0	1.1
Average weekly spirits intake	0.9	1.1	2.2	1.1	0.6	-1.1	-1.5	-0.9	-1.2	-0.7
Sensitivity / hurt feelings	0.3	0.5	1.4	-0.8	0.1	-1.2	0.3	-0.1	-0.9	-0.4
Frequency of depressed mood in last 2 weeks	2.1	3.0	4.3	-2.1	-1.8	-1.6	1.8	-1.4	-1.6	-1.7
Hearing difficulty/problems: Yes	0.5	0.8	1.4	-1.0	-1.2	-0.8	-0.1	-0.5	-1.1	-0.8
Relative age of first facial hair	0.3	0.6	3.1	1.8	0.7	0.1	0.5	0.6	0.1	0.5
Other serious medical condition/disability diagnosed by doctor	0.1	0.1	0.3	0.0	0.4	0.3	0.3	0.5	0.4	0.4
Ever used hormone-replacement therapy (HRT)	1.8	2.3	8.4	2.2	-0.2	-1.0	-2.9	-0.6	-1.3	-0.5
Ever had hysterectomy (womb removed)	0.4	0.5	0.8	0.5	-0.6	-0.9	-0.8	-0.3	-0.9	-0.4
Systolic blood pressure, automated reading	0.6	1.6	8.2	0.8	0.1	-1.2	-2.9	-0.5	-0.9	-0.2
Eye problems/disorders: Diabetes related eye disease	0.2	0.3	0.7	-0.9	0.4	-0.1	-0.7	0.2	-0.4	0.3
Angina	1.6	2.1	3.8	-0.6	-0.9	-1.7	-0.5	-1.9	-2.0	-1.8
Medication for hormone replacement therapy	0.6	0.6	1.0	0.8	-0.8	0.7	-0.6	1.0	0.5	1.0
Vitamin and mineral supplements	1.5	2.0	5.3	1.1	-0.1	-1.5	-2.3	-1.2	-1.7	-1.0
Supplements: Zinc	0.7	0.7	1.8	-0.9	-1.0	0.2	1.4	0.8	0.5	0.7
Medication: Co-codamol	0.6	0.7	1.2	0.5	0.3	0.8	-0.9	1.1	0.9	1.0
Medication: Metformin	1.4	2.0	5.7	0.6	1.6	1.1	-2.4	1.3	0.4	1.5
Diabetes (father)	0.3	0.4	0.6	-0.7	0.7	0.5	-0.5	0.6	0.5	0.8
Diabetes (mother)	1.0	1.3	5.0	0.9	0.5	-1.1	-2.2	-0.8	-0.9	-0.7
Severe depression (siblings)	0.3	0.3	0.9	0.1	-0.5	0.4	1.0	0.7	0.2	0.6
Pack years adult smoking proportion	1.5	2.2	8.0	1.9	-0.4	-1.0	-2.8	-1.2	-0.9	-0.7
Impedance of leg (right)	0.7	3.3	16.0	-0.3	-1.8	-0.8	4.0	-0.9	-0.7	-1.4
Leg fat-free mass (left)	0.7	4.0	22.0	0.6	1.3	0.4	-4.7	1.1	0.6	1.4
Trunk fat percentage	1.6	6.5	38.1	2.0	1.7	-0.8	-6.2	-0.2	-0.3	0.1
Hand grip strength (right)	0.7	2.0	4.1	-0.1	2.0	1.0	-1.9	1.4	1.1	1.5
Townsend deprivation index at recruitment	0.2	0.3	1.0	0.4	0.4	-0.6	-1.0	-0.6	-0.4	-0.3
Current tobacco smoking	0.1	0.1	0.3	-0.1	0.0	-0.1	-0.6	0.6	0.1	0.5
Average weekly fortified wine intake	1.0	1.2	2.4	0.8	1.5	1.1	1.0	1.1	0.8	1.1
Maternal smoking around birth	5.1	7.3	20.1	3.7	2.0	1.1	-4.5	2.0	1.6	2.3
Fed-up feelings	1.1	2.0	3.5	-1.9	-0.9	-1.7	1.1	-0.8	-1.8	-1.2
Frequency of unenthusiasm / disinterest in last 2 weeks	1.1	1.4	5.0	-1.9	-0.6	-0.6	2.2	-0.2	-0.7	-0.2
Relative age voice broke	0.7	1.0	1.7	0.7	1.1	1.3	0.6	1.1	0.8	1.3
Taking other prescription medications	0.5	0.8	3.9	0.4	1.3	0.1	-2.0	-0.0	0.2	0.3
Age when periods started (menarche)	0.6	1.4	4.8	0.6	1.0	1.0	2.2	0.9	1.1	0.7
Bilateral oophorectomy (both ovaries removed)	0.3	0.3	1.4	1.2	-0.1	-0.3	-0.7	0.2	-0.3	0.2
Heel bone mineral density (BMD) T-score, automated (left)	0.5	1.2	2.3	0.1	0.7	1.5	0.7	1.2	1.4	1.1
Tinnitus: Yes, but not now, but have in the past	0.6	0.7	2.6	0.6	-0.4	-0.4	-1.6	-1.1	-0.2	-0.4
Qualifications: CSEs or equivalent	0.7	0.9	3.9	-0.1	-0.4	0.1	-2.0	1.1	0.5	0.9
Serious illness, injury or assault to yourself	0.5	0.7	2.1	0.2	1.4	0.4	-1.4	0.5	0.2	0.5
High blood pressure	0.3	0.9	3.4	-0.3	1.8	0.7	-1.4	0.2	0.3	0.6
Hayfever, allergic rhinitis or eczema	1.6	3.4	15.2	-2.0	-2.1	-0.3	3.9	0.0	-0.1	-0.5
Multivitamins +/- minerals	1.7	2.2	4.0	-0.5	0.2	1.8	1.2	1.8	2.0	1.7
Stomach or abdominal pain in last month	0.7	0.8	2.2	0.1	0.9	0.4	0.9	1.5	0.6	1.2
Supplements: Glucosamine	2.2	2.9	5.4	0.7	2.3	1.8	-0.7	1.9	1.8	1.9
Diverticular disease/diverticulitis (self-reported)	0.3	0.3	1.6	-1.2	-0.1	-0.2	0.4	-0.6	-0.1	-0.3
Medication: Atenolol	0.6	0.8	2.9	0.9	1.2	-0.0	-1.7	0.3	0.2	0.2
Medication: Levothyroxine sodium	0.1	0.1	0.4	0.1	-0.3	-0.0	0.6	0.1	0.4	-0.2
Sitting height	0.2	1.6	5.8	-1.7	-1.3	0.3	2.4	0.7	0.1	0.2
Chronic bronchitis/emphysema (father)	1.1	1.2	2.5	-0.6	-0.7	-1.6	-0.9	-1.1	-1.2	-1.4
High blood pressure (mother)	1.8	2.6	14.0	1.5	0.6	-0.6	-3.7	-1.0	-0.4	-0.3
Body mass index (BMI)	2.7	11.4	65.8	2.7	2.5	-0.3	-8.1	0.1	0.2	0.9
Impedance of leg (left)	0.8	3.9	16.9	-1.3	-1.7	-0.9	4.1	-1.1	-0.8	-1.7
Leg predicted mass (left)	0.8	4.1	22.2	0.6	1.4	0.4	-4.7	1.1	0.7	1.4
Trunk fat mass	1.6	6.9	41.8	1.7	1.6	-0.8	-6.5	-0.2	-0.2	0.2
Waist circumference	3.1	11.2	59.4	2.7	2.8	-0.1	-7.7	1.1	0.5	1.5
Number of incorrect matches in round	4.2	7.0	13.1	2.2	-2.2	-3.6	-2.7	-2.1	-3.2	-2.2
Past tobacco smoking	0.3	0.6	3.1	-0.0	-0.7	-0.7	1.7	0.0	0.0	-0.5
Alcohol usually taken with meals	0.4	0.6	1.5	0.2	-0.7	0.6	1.2	1.0	0.6	0.7
Nervous feelings	0.7	1.3	2.2	0.0	-1.2	-1.3	1.5	-1.0	-1.2	-1.2
Frequency of tenseness / restlessness in last 2 weeks	0.1	0.2	0.5	-0.1	-0.4	-0.5	0.5	-0.1	-0.7	0.0
Hearing difficulty/problems with background noise	0.3	0.5	1.5	1.1	-0.2	-0.4	-1.2	0.1	-0.5	-0.0
Hair/balding pattern: Pattern 2	0.6	0.7	1.7	1.0	-0.8	-1.3	-0.6	-0.3	-1.1	-0.4
Had menopause	0.2	0.2	0.7	0.3	-0.4	-0.2	0.2	-0.9	-0.2	-0.7
Had other major operations	0.2	0.2	0.9	0.3	0.2	0.3	-1.0	0.4	0.4	0.5
Forced vital capacity (FVC)	0.9	3.6	10.3	-3.2	-1.3	-0.7	2.9	-1.4	-0.7	-1.5
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.2	0.8	-0.1	-0.4	0.4	0.9	0.4	0.3	0.2
Ever unenthusiastic/disinterested for a whole week	0.2	0.2	0.4	0.6	0.7	0.4	-0.3	0.4	0.1	0.4
Qualifications: None of the above	2.1	4.5	20.2	2.5	1.8	-0.9	-4.5	-0.7	-0.6	-0.2
Financial difficulties in last 2 years	0.6	0.9	3.1	0.6	0.5	-0.6	-1.8	1.0	-0.4	0.8
Mouth/teeth dental problems	0.4	0.6	1.8	0.1	0.3	1.2	0.5	0.4	1.3	0.6
Heart attack	1.3	1.7	3.8	0.7	1.9	1.2	-0.8	1.3	1.3	1.4
Allergy	0.9	2.1	10.3	1.7	1.1	-0.1	-3.2	-0.4	-0.1	0.0
Pain all over the body in last month	0.4	0.4	1.8	0.1	1.3	0.6	-0.1	-0.4	0.6	0.2
Diabetes (self-reported)	0.8	1.3	2.3	0.5	1.0	0.9	-1.5	1.5	0.5	1.4
Hayfever/allergic rhinitis (self-reported)	1.2	1.6	2.9	-0.5	0.9	1.7	0.5	1.5	1.7	1.3
Medication: Ramipril	0.5	0.6	1.6	1.0	1.3	0.1	-0.9	0.7	0.1	0.6
Medication: Simvastatin	1.1	1.6	3.8	1.1	1.9	1.3	-1.7	0.5	0.9	0.9
Fluid intelligence score	2.9	6.1	25.4	-3.1	-1.6	-0.7	5.0	-0.9	-1.0	-1.5
Illnesses of siblings	3.7	5.3	8.9	-1.9	1.1	3.0	2.9	1.9	2.6	2.1
Neuroticism score	1.1	2.4	4.5	-2.1	-1.1	-1.6	2.0	-0.7	-1.6	-1.1
Weight	1.4	6.9	41.6	1.4	1.8	-0.1	-6.5	0.6	0.4	1.0
Impedance of arm (right)	0.7	3.3	20.1	0.2	-0.8	1.0	4.5	0.8	0.8	0.1
Arm fat percentage (right)	2.3	9.0	49.2	2.7	2.3	0.1	-7.0	0.3	0.5	0.8
Trunk fat-free mass	0.2	1.0	4.9	-0.3	0.5	0.4	-2.2	0.8	0.5	1.0
Hip circumference	1.1	4.8	29.8	0.7	1.6	-0.2	-5.5	0.3	0.3	0.6
Time employed in main current job	0.1	0.1	0.6	-0.3	-0.0	0.1	0.2	-0.8	-0.0	-0.3
Alcohol intake versus 10 years previously	1.1	1.7	3.6	1.6	1.3	1.3	-1.2	0.4	1.9	0.9
Father’s age at death	1.4	1.9	8.6	0.6	-0.6	1.0	2.9	1.3	0.7	1.0
Worrier / anxious feelings	0.2	0.3	1.1	-0.9	-0.5	-0.5	1.1	-0.0	-0.2	-0.1
Frequency of tiredness / lethargy in last 2 weeks	0.5	0.8	2.6	-1.4	-0.4	-0.4	1.6	0.4	-0.5	-0.1
Falls in the last year	0.9	1.2	4.3	-2.1	0.9	-0.1	-0.5	1.3	0.2	1.0
Hair/balding pattern: Pattern 3	0.7	1.0	2.0	0.5	-1.2	-1.4	-0.3	-0.9	-1.1	-1.2
Number of live births	0.2	0.3	0.7	-0.4	0.8	0.0	0.3	0.9	-0.3	0.5
Forced expiratory volume in 1-second (FEV1)	0.6	2.1	8.0	-2.8	-0.9	-0.0	2.0	-0.8	-0.1	-0.9
Pulse rate	0.1	0.1	0.5	0.3	0.0	-0.1	-0.5	0.7	0.0	0.3
Happiness	0.8	0.9	2.2	-1.5	-0.7	-1.0	1.2	-0.3	-1.0	-0.6
Noisy workplace	2.5	3.1	12.9	2.4	1.4	0.5	-3.6	-0.5	0.6	0.3
Qualifications: A levels/AS levels or equivalent	2.1	4.7	13.6	-3.1	0.6	1.7	3.7	1.6	1.6	1.0
Serious illness, injury or assault of a close relative in last 2 years	1.0	1.1	7.3	-0.4	-0.3	0.4	2.7	0.1	0.3	-0.2
Mouth/teeth dental problems: Dentures	1.1	1.9	4.4	0.0	1.3	1.2	-2.1	1.6	0.9	1.6
Asthma	1.2	2.4	11.2	-1.3	-0.1	1.1	3.4	1.3	0.6	0.9
Medication: Ibuprofen (e.g. Nurofen)	0.8	1.0	1.7	1.3	-1.3	-0.9	-0.0	-0.4	-1.1	-1.0
Medication: Cholesterol lowering	1.1	1.7	3.8	0.3	2.0	1.4	-1.6	0.7	1.0	1.4
Depression (self-reported)	1.4	1.6	6.3	-2.5	-1.3	-0.4	1.2	-0.9	-0.5	-0.9
Medication: Lansoprazole	2.6	3.0	5.8	1.5	2.4	1.6	-2.1	0.9	1.5	1.6
Prospective memory result	0.5	0.6	1.4	1.1	-0.9	-0.7	-1.2	-0.2	-0.3	-0.3
Lung cancer (father)	0.3	0.4	0.8	0.0	-0.2	0.9	-0.3	0.7	0.8	0.9
Illnesses of mother	4.7	5.8	23.2	-2.6	-0.4	1.7	4.8	1.8	1.6	1.3
Forced expiratory volume in 1-second (FEV1), Best measure	0.5	1.4	7.7	-2.8	-0.9	0.0	1.1	-0.5	0.2	-0.5
Pulse wave Arterial Stiffness index	0.5	0.5	1.0	0.1	-0.8	-0.9	-0.6	-0.5	-1.0	-0.7
Impedance of arm (left)	0.7	3.4	22.2	-0.0	-1.0	0.6	4.7	0.5	0.4	-0.2
Arm fat mass (right)	2.3	9.5	54.5	2.6	2.1	-0.3	-7.4	0.2	0.2	0.8
Trunk predicted mass	0.2	1.1	5.1	-0.2	0.5	0.5	-2.2	0.9	0.7	1.1
Standing height	0.3	2.6	8.9	-2.3	-1.4	0.5	3.0	1.1	0.5	0.4
Length of working week for main job	2.4	2.6	5.3	-0.5	-1.0	-2.2	-0.3	-1.8	-2.3	-1.9
Exposure to tobacco smoke at home	1.6	1.7	3.7	-1.1	-1.9	-1.5	-0.5	-1.3	-0.8	-1.5
Breastfed as a baby	0.4	0.6	1.4	-0.1	1.2	0.7	0.7	0.7	0.7	0.8
Tense / ‘highly strung’	5.0	8.3	12.6	-3.0	-3.3	-3.4	2.2	-1.8	-3.6	-2.6
Seen doctor (GP) for nerves, anxiety, tension or depression	0.9	1.4	3.9	-2.0	-1.4	-0.9	1.1	-0.5	-0.7	-0.8
Hair/balding pattern: Pattern 4	0.2	0.5	1.1	-0.9	0.8	0.7	1.1	0.2	0.7	0.2
Birth weight of first child	0.3	0.5	1.4	-0.4	0.8	1.2	0.4	0.7	0.8	0.6
Peak expiratory flow (PEF)	0.8	1.9	6.2	-2.5	0.3	1.3	1.7	0.5	1.3	0.4
Pulse wave reflection index	0.4	0.5	1.1	-0.6	-0.4	-0.5	-0.1	-0.9	-1.0	-0.8
Ever highly irritable/argumentative for 2 days	0.4	0.4	2.0	0.9	0.2	-0.1	-1.4	-0.3	-0.2	-0.1
Loud music exposure frequency	0.2	0.2	0.8	0.6	-0.2	-0.0	0.4	-0.9	-0.2	-0.6
Qualifications: O levels/GCSEs or equivalent	3.0	4.8	17.5	-4.2	-0.8	0.7	3.8	-0.0	0.0	-0.3
Mouth/teeth dental problems: Bleeding gums	0.6	0.8	3.2	-1.0	-0.9	-0.5	1.8	-0.1	-0.3	-0.5
Blood clot in the leg (DVT)	1.0	1.3	2.7	0.4	1.3	0.9	-1.6	1.1	0.9	1.4
Medication: Paracetamol	1.1	1.8	7.0	0.7	1.6	0.3	-2.6	1.1	0.3	1.1
Headache pain in last month	0.4	0.8	1.4	-0.6	1.1	0.3	-0.9	1.2	0.6	0.9
Medication for cholesterol, blood pressure or diabetes	0.8	1.4	4.9	-1.4	-1.4	-0.5	2.2	-0.0	-0.3	-0.6
Glaucoma (self-reported)	0.6	0.8	1.7	0.6	1.3	1.2	-0.1	0.4	1.2	0.6
Gout (self-reported)	0.7	1.0	3.3	-1.8	0.7	0.6	1.2	1.0	0.5	0.6
Hypothyroidism/myxoedema (self-reported)	0.6	1.1	3.9	-1.0	-0.0	1.0	2.0	0.4	1.3	0.3
Medication: Amlodipine	0.8	1.1	5.5	-0.2	-0.7	-0.5	-2.3	-0.5	-1.0	-0.3
Medication: Ventolin 100micrograms inhaler	3.1	4.0	7.5	0.6	1.6	2.7	0.1	2.2	2.5	2.5
Birth weight	0.2	0.5	1.6	-0.4	0.4	-0.3	-1.3	-0.8	-0.7	-0.6
Chronic bronchitis/emphysema (mother)	2.0	2.3	5.0	-0.3	-0.7	-2.2	-1.4	-1.4	-2.0	-1.6
High blood pressure (siblings)	4.0	5.8	11.0	1.6	-1.4	-3.3	-1.7	-2.5	-3.0	-2.6
Forced vital capacity (FVC), Best measure	0.8	3.0	12.1	-3.5	-1.3	-0.5	2.2	-0.9	-0.3	-1.0
Body fat percentage	1.9	7.6	45.2	1.9	1.9	-0.8	-6.7	-0.3	-0.1	0.2
Leg fat percentage (right)	2.2	7.9	47.2	2.0	1.7	-0.9	-6.9	-0.6	-0.2	0.1
Arm fat-free mass (right)	0.5	2.5	15.7	-0.2	0.8	-0.0	-4.0	0.7	0.3	0.9
Exposure to tobacco smoke outside home	2.2	2.9	8.4	-1.2	-2.9	-1.6	0.8	-1.4	-1.5	-1.7
Comparative body size at age 10	2.8	7.6	38.6	1.6	1.0	-1.9	-6.2	-1.6	-2.0	-0.9
Number of full brothers	0.7	0.8	1.6	0.5	0.9	1.0	0.1	1.0	1.0	1.2
Worry too long after embarrassment	1.6	2.8	4.5	-0.5	-1.3	-1.8	1.3	-2.1	-1.8	-2.1
Seen a psychiatrist for nerves, anxiety, tension or depression	1.6	2.1	8.5	-2.9	-1.2	-1.1	1.2	-0.5	-0.9	-1.0
Wheeze or whistling in the chest in last year	0.2	0.4	1.4	-0.1	-1.2	-0.6	0.4	0.4	-0.7	0.2
Number of children fathered	1.9	2.1	4.5	1.4	0.1	-1.1	-2.1	-2.0	-1.2	-1.2
Reason for reducing amount of alcohol drunk: Health precaution	1.3	1.5	3.7	-1.7	-0.7	-0.5	1.9	-1.1	-0.8	-1.1
Age at first live birth	0.6	1.0	3.7	0.0	0.3	1.0	1.9	0.3	1.4	0.3
Pulse wave peak to peak time	0.5	0.6	1.0	-0.3	0.7	0.8	1.0	0.5	1.0	0.7
Health satisfaction	0.9	1.2	2.3	1.3	0.8	0.3	-1.4	1.5	0.3	1.3
Shortness of breath walking on level ground	0.9	1.0	1.8	-1.3	-1.4	-1.2	-0.0	-0.4	-1.3	-0.7
Qualifications: College or University degree	1.6	5.1	20.0	-2.1	0.0	2.0	4.5	1.5	1.9	1.1
Eye problems/disorders: None of the above	0.9	1.0	2.3	-0.4	0.1	1.0	1.5	1.0	1.4	0.9
Mouth/teeth dental problems: Loose teeth	1.4	1.7	3.1	1.1	-1.8	-1.7	-0.4	-0.8	-1.7	-1.0
Emphysema/chronic bronchitis	0.3	0.3	1.2	-0.2	0.1	-0.3	-1.1	-0.6	-0.4	-0.3
Medication for pain relief, constipation, heartburn	0.4	0.7	3.2	-0.9	-0.9	0.0	1.8	-0.3	-0.0	-0.3
Neck or shoulder pain in last month	0.9	1.3	5.1	0.3	0.8	0.3	-2.2	1.1	0.6	1.2
Medication: Blood pressure	0.7	1.2	3.2	0.6	0.4	-1.1	-1.8	-1.1	-1.2	-0.9
Angina (self-reported)	1.3	1.8	3.5	-0.5	-0.6	-1.5	-0.7	-1.9	-1.8	-1.6
Migraine (self-reported)	2.1	2.6	5.8	2.4	1.1	1.4	-1.8	1.0	1.5	1.5
Medication: Ibuprofen	0.3	0.4	0.9	1.0	-0.4	-0.4	-0.2	-0.3	-0.8	-0.7
Medication: Allopurinol	0.2	0.2	1.6	-1.3	0.3	0.2	0.1	-0.2	0.1	-0.0
Medication: Omeprazole	1.1	1.3	3.6	1.8	1.4	-0.4	-1.9	0.1	-0.2	0.4
Medication: Seretide 50 evohaler	0.5	0.5	2.4	1.5	-0.4	-0.8	0.4	0.1	-0.5	-0.3
Mean time to correctly identify matches	0.3	0.5	1.7	1.3	0.5	-0.1	0.3	-0.8	-0.5	-0.6
Heart disease (mother)	1.0	1.2	3.1	0.9	0.0	-1.3	-1.8	-1.0	-0.9	-1.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.5	0.6	1.1	-0.6	-0.7	-0.8	-0.4	-1.1	-0.6	-1.0
Whole body fat mass	2.1	8.7	52.6	1.9	1.8	-0.9	-7.3	-0.2	-0.2	0.3
Leg fat mass (right)	2.6	10.1	61.7	2.1	2.0	-0.8	-7.9	-0.2	-0.1	0.4
Arm predicted mass (right)	0.5	2.7	16.9	-0.2	0.9	-0.2	-4.1	0.5	0.1	0.8
Pulse rate, automated reading	0.1	0.4	2.6	-0.2	0.4	-0.4	-1.6	-0.1	-0.3	0.3
Alcohol intake frequency.	0.2	0.5	1.2	-0.8	-0.4	-1.1	-1.0	0.0	-0.4	-0.5
Comparative height size at age 10	0.4	2.4	4.1	-1.0	-1.5	-1.6	-0.0	-2.0	-1.6	-2.0
Number of full sisters	2.0	2.5	4.6	0.3	-1.3	-2.2	-0.8	-1.9	-1.8	-1.9
Suffer from ‘nerves’	1.1	1.8	5.5	-2.2	-0.6	-0.3	2.4	-0.7	-0.7	-0.7
Overall health rating	0.4	0.8	4.2	0.6	0.6	-0.6	-2.0	-0.2	-0.3	-0.0
Chest pain or discomfort	1.1	1.5	4.2	-1.3	0.3	1.1	2.0	1.3	0.9	1.1
Had major operations	2.5	3.0	5.5	0.8	1.9	1.8	-0.7	2.3	1.9	2.0
Age at last live birth	0.3	0.5	2.7	-0.3	-0.5	-0.1	1.6	-0.2	0.0	-0.4
Family relationship satisfaction	0.7	0.9	4.0	-1.1	-0.5	-0.6	2.0	-0.3	-0.3	-0.6
Leg pain on walking	0.7	0.8	2.5	1.2	-1.6	-0.8	0.5	-0.3	-0.8	-0.6
Qualifications: NVQ or HND or HNC or equivalent	0.6	0.8	1.9	-0.2	-1.1	-0.7	-1.4	-0.7	-1.1	-0.3
Commuting to job workplace: Car/motor vehicle	0.3	0.4	0.5	-0.6	-0.4	-0.7	-0.6	-0.7	-0.7	-0.6
Illness, injury, bereavement, stress in last 2 years	0.1	0.2	0.5	-0.1	-0.7	-0.3	-0.6	-0.3	-0.2	-0.2
Medication: Aspirin	0.6	0.7	1.4	0.5	1.1	1.1	-1.2	-0.1	0.9	0.7
Supplements: Vitamin C	2.0	2.3	3.7	-0.9	1.0	1.9	1.8	1.4	1.8	1.5
Knee pain experienced in last month	1.5	2.3	4.6	0.5	-1.3	-1.8	-2.1	-1.4	-1.3	-1.5
Hypertension (Self-reported)	0.4	1.0	3.6	-0.2	1.9	0.6	-1.7	0.0	0.2	0.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.1	0.1	0.3	0.5	0.1	-0.2	0.6	-0.1	-0.1	-0.2
Illnesses of father: Heart disease	0.3	0.5	1.2	0.1	1.1	-0.6	-0.4	-0.6	-0.7	-0.7
Illnesses of siblings: Diabetes	0.4	0.5	1.0	1.0	-0.0	-0.9	-1.0	-0.2	-0.8	-0.5
Smoking status: Previous	0.7	1.0	4.6	1.2	0.9	0.4	-2.2	-0.5	-0.3	0.2
Forced expiratory volume in 1-second (FEV1), predicted	0.3	0.6	1.9	-1.2	-0.8	0.2	1.4	0.3	0.5	0.1
Whole body fat-free mass	0.4	2.4	12.1	0.0	1.0	0.5	-3.5	1.1	0.7	1.3
Leg fat-free mass (right)	0.6	3.5	18.0	0.0	1.4	0.5	-4.2	1.2	0.7	1.4
Arm fat percentage (left)	2.1	8.2	45.4	2.5	2.3	-0.0	-6.7	0.2	0.4	0.7
Average weekly red wine intake	0.0	0.1	0.2	0.4	-0.3	-0.1	-0.3	-0.1	-0.2	-0.1
Handedness (chirality/laterality): Left-handed	0.7	0.8	4.0	2.0	0.7	0.4	-0.9	0.3	0.2	0.5
Mood swings	0.9	1.6	2.3	-0.8	-0.6	-1.1	1.3	-1.5	-1.5	-1.5
Loneliness, isolation	0.1	0.1	0.3	0.3	0.1	0.2	0.5	0.2	0.2	0.2
Long-standing illness, disability or infirmity	1.0	1.5	3.3	-1.2	-1.2	-1.6	0.7	-0.3	-1.8	-0.8
Ever had bowel cancer screening	0.4	0.5	2.6	-0.5	-0.8	0.1	1.6	-0.0	0.2	-0.2
Diabetes diagnosed by doctor	0.5	0.9	3.1	0.6	0.7	0.3	-1.8	1.0	-0.1	0.9
Ever had stillbirth, spontaneous miscarriage or termination	1.8	1.9	4.9	-1.4	0.3	1.3	2.2	1.7	1.0	1.1
Friendships satisfaction	1.8	2.2	3.8	-1.2	-1.9	-1.4	1.9	-1.0	-1.3	-1.4
Qualifications: nursing, teaching	1.5	2.3	5.2	-1.2	1.2	2.2	1.4	0.9	2.3	1.0
Commuting to job workplace: Walk	0.8	0.8	2.7	-1.0	1.0	0.6	1.6	0.7	0.2	0.4
Eye problems/disorders: Cataract	0.5	0.6	1.2	1.0	0.5	-0.5	-1.1	-0.8	-0.6	-0.6
Mouth/teeth dental problems: Mouth ulcers	0.2	0.4	1.7	0.8	-0.1	-0.3	1.3	0.1	-0.5	-0.2
Medication for cholesterol	0.6	1.0	4.2	0.2	-0.6	-1.1	2.0	-0.1	-0.7	-0.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.0	1.2	2.6	-0.4	0.9	1.1	-0.7	1.6	0.8	1.6
Back pain experienced in last month	0.1	0.2	0.4	-0.6	-0.2	-0.5	-0.5	0.4	-0.4	0.1
Mineral and other dietary supplements	2.3	3.1	5.8	-1.3	-1.4	-2.0	-0.1	-2.0	-2.4	-2.2
Breast cancer (self-reported)	0.8	1.0	3.1	1.4	0.7	-0.6	-1.8	-0.6	-0.5	-0.5
Asthma (self-reported)	1.1	2.3	11.3	-1.1	-0.1	1.2	3.4	1.1	0.5	0.8
Osteoporosis (self-reported)	0.5	0.6	1.0	1.0	-0.1	-1.0	-0.7	-0.8	-0.8	-0.8
Osteoarthritis (self-reported)	0.4	0.5	2.6	1.6	0.3	0.3	-0.5	0.6	0.2	0.3
Medication: Aspirin	0.4	0.6	1.3	0.3	1.2	0.8	-1.1	-0.2	0.5	0.5
Medication: Gliclazide	1.1	1.2	2.7	-0.7	0.7	1.1	-0.0	1.6	1.0	1.6
Illnesses of father: None of the above (group 1)	0.3	0.4	1.4	0.4	-0.1	0.5	-1.2	-0.7	0.7	-0.2
Smoking status: Current	0.2	0.3	1.2	-1.1	-0.2	0.0	0.1	0.7	0.3	0.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.1	2.4	5.6	0.5	-0.3	-1.7	-1.5	-2.4	-1.4	-1.9
Whole body water mass	0.4	2.4	12.4	0.1	1.1	0.5	-3.5	1.0	0.7	1.3
Leg predicted mass (right)	0.6	3.4	18.1	0.1	1.4	0.5	-4.3	1.2	0.6	1.4
Arm fat mass (left)	2.3	9.4	52.4	2.5	2.4	-0.0	-7.2	0.3	0.4	0.9
Number of self-reported non-cancer illnesses	0.2	0.3	1.1	0.7	0.2	0.1	-1.0	0.4	0.2	0.3
Average weekly champagne plus white wine intake	0.4	0.6	2.5	-0.4	-1.0	0.1	1.6	0.7	0.2	0.2
Miserableness	1.1	2.0	7.0	-2.6	-0.1	-0.9	1.7	-0.9	-1.0	-1.1
Guilty feelings	0.3	0.4	1.7	-1.1	-0.1	-0.1	1.3	-0.2	0.1	-0.3
Wears glasses or contact lenses	0.4	0.5	0.7	-0.8	0.3	-0.8	-0.9	-0.7	-0.3	-0.7
Ever taken oral contraceptive pill	0.8	0.9	4.0	-0.8	-0.7	0.8	2.0	0.7	0.2	0.4
Hearing aid user	0.2	0.3	0.7	-0.8	0.3	-0.3	0.1	0.8	-0.4	0.2
Mother’s age at death	1.3	1.7	9.3	-0.9	-0.9	0.7	3.1	-0.1	0.5	-0.3
Financial situation satisfaction	0.3	0.4	1.3	0.4	-0.6	-0.7	-1.1	0.6	-0.5	0.3
Tinnitus: Yes, now most or all of the time	3.3	3.8	7.3	0.0	-0.9	-2.7	-1.3	-2.2	-2.5	-2.4
Commuting to job workplace: Public transport	1.8	2.2	5.3	0.6	0.3	1.3	2.3	1.9	1.4	1.5
Eye problems/disorders: Glaucoma	0.6	0.8	1.6	0.1	1.2	1.1	-0.3	0.7	1.3	0.8
Medication: Blood pressure	1.0	1.9	4.4	-0.2	2.1	1.2	-2.0	0.4	1.3	1.1
Pain type(s) experienced in last month: Hip pain	1.8	2.2	5.1	1.2	2.3	0.8	-1.6	1.6	0.9	1.6
Supplements: Fish oil (including cod liver oil)	2.1	2.7	4.8	1.2	1.3	2.0	0.2	1.7	2.2	1.9
High cholesterol (Self-reported)	1.0	1.8	3.5	0.1	1.9	1.5	-1.8	0.8	1.2	1.3
Medication: Bendroflumethiazide	0.3	0.4	1.3	0.5	1.1	0.2	-0.9	0.1	0.4	0.5
Medication: Paracetamol	1.3	1.9	6.0	0.8	2.5	0.6	-2.0	1.0	0.4	1.1
Medication: Lisinopril	0.2	0.3	1.2	-0.6	0.2	0.2	-1.1	-0.5	0.0	0.0
Medication: Atorvastatin	0.9	1.1	3.8	-1.9	-0.2	-0.4	-2.0	0.2	-0.6	0.2
Illnesses of father: High blood pressure	0.4	0.5	1.1	1.1	-0.1	0.4	0.6	1.0	0.4	0.7
Alcohol drinker status: Never	0.2	0.3	0.7	-0.8	0.2	0.6	0.8	0.5	0.1	0.2
Ever smoked	0.2	0.4	1.1	-0.6	0.9	1.1	-0.5	-0.0	0.4	0.6
Basal metabolic rate	0.6	3.5	19.9	0.4	1.3	0.4	-4.5	1.0	0.6	1.3
Leg fat percentage (left)	2.1	7.8	47.5	1.5	1.8	-0.8	-6.9	-0.6	-0.1	-0.0
Arm fat-free mass (left)	0.7	3.5	20.7	0.3	1.5	0.3	-4.5	0.6	0.6	1.1
Number of operations (self-reported)	1.4	2.1	2.8	0.8	1.6	1.5	-1.5	1.4	1.6	1.7
Average weekly beer plus cider intake	1.2	1.7	4.0	-2.0	-1.2	-1.1	1.2	-1.0	-1.0	-1.3
Irritability	1.5	2.5	8.8	-2.1	-1.6	-0.8	3.0	0.5	-0.9	-0.4
Risk taking	0.1	0.1	0.3	0.6	0.1	0.4	0.4	0.4	0.0	0.1
Ever had prostate specific antigen (PSA) test	0.1	0.1	0.4	0.0	0.6	0.1	0.4	0.2	0.4	0.2
Fractured/broken bones in last 5 years	0.8	1.0	2.2	-1.5	0.1	0.9	1.2	1.1	0.5	0.9
Age started oral contraceptive pill	0.8	1.0	5.3	2.3	0.5	0.1	-0.8	-0.9	-0.2	-0.4
Diastolic blood pressure, automated reading	0.9	2.6	11.3	1.3	1.2	0.5	-3.4	1.1	0.7	1.4
Ever depressed for a whole week	0.3	0.4	1.3	0.5	0.1	0.1	-1.1	0.8	-0.0	0.5
Unable to work because of sickness or disability	1.1	1.5	5.7	1.1	1.7	0.2	-2.4	-0.2	0.5	0.4
Commuting to job workplace: Cycle	1.6	1.9	3.8	1.0	0.9	1.5	0.4	1.9	1.7	1.6
Myopia	0.5	0.7	1.7	0.8	0.7	0.9	0.8	0.6	1.3	0.6
Vascular/heart problems diagnosed by doctor	0.3	0.9	3.5	0.3	-1.9	-0.9	1.1	-0.2	-0.5	-0.7
Cholesterol lowering medication	0.4	0.5	2.2	-1.5	0.3	0.1	-1.2	0.0	0.1	-0.1
Medication: Omeprazole (e.g. Zanprol)	1.2	1.4	3.7	1.9	1.8	0.0	-1.6	0.2	0.2	0.5
Pain experienced in last month	0.7	1.1	2.2	1.3	0.1	1.5	0.8	0.8	1.2	0.9
Supplements: Calcium	0.6	0.7	1.9	-1.2	-0.9	0.7	1.4	0.1	0.4	0.2
Basal cell carcinoma (self-reported)	0.5	0.6	2.7	-0.5	-1.6	-0.2	0.6	-0.2	-0.5	-0.5
Heart attack/myocardial infarction (self-reported)	1.0	1.2	3.1	0.4	1.8	1.0	-0.6	1.1	1.1	1.2
Deep venous thrombosis (DVT) (self-reported)	1.0	1.2	3.3	0.3	1.2	0.8	-1.8	1.0	0.8	1.3
Heart disease (siblings)	0.8	0.9	3.2	0.2	0.3	-1.0	-1.8	-0.9	-0.7	-0.9
Alcohol drinker status: Previous	1.2	1.3	2.0	-1.2	0.8	0.9	-0.8	1.4	1.3	1.4
Pack years of smoking	1.1	1.6	5.9	1.8	0.1	-0.6	-2.4	-0.9	-0.6	-0.5
Impedance of whole body	0.8	4.0	23.6	-0.7	-1.6	-0.2	4.9	-0.2	-0.2	-1.0
Leg fat mass (left)	2.6	10.2	62.3	1.9	2.1	-0.8	-7.9	-0.3	-0.1	0.4
Arm predicted mass (left)	0.7	3.6	21.3	0.4	1.4	0.2	-4.6	0.6	0.5	1.1