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chr17:26,375,467-29,547,601

Best TWAS P=1.51e-10 · Best GWAS P=9.05e-11 conditioned to 3.19e-05

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	EFCAB5	0.11	0.18	blup	392	0.17	1.7e-20	-5.4	-5.7	1.3e-08	-0.58	0.30	0.70	FALSE
2	GTEx	Brain Cortex	GOSR1	0.20	0.20	enet	7	0.18	1.4e-05	4.7	5.2	2.1e-07	0.48	0.75	0.12	FALSE
3	GTEx	Brain Nucleus accumbens basal ganglia	CORO6	0.11	0.10	lasso	2	0.05	2.2e-02	-5.5	5.6	2.1e-08	0.57	0.07	0.73	FALSE
4	GTEx	Cells Transformed fibroblasts	TRAF4	0.08	0.08	lasso	5	0.11	2.2e-08	-4.3	5.4	5.3e-08	-0.01	0.42	0.52	TRUE
5	GTEx	Lung	SSH2	0.08	0.05	lasso	6	0.06	2.7e-05	-5.2	-5.9	3.8e-09	-0.64	0.25	0.75	FALSE
6	GTEx	Nerve Tibial	SSH2	0.05	0.06	lasso	10	0.06	7.8e-05	-5.4	-5.5	4.3e-08	-0.52	0.28	0.71	FALSE
7	GTEx	Skin Sun Exposed Lower leg	RP11-68I3.4	0.03	0.00	lasso	3	0.00	4.5e-01	4.8	-5.2	2.3e-07	-0.49	0.08	0.17	FALSE
8	GTEx	Thyroid	GIT1	0.06	0.08	lasso	5	0.09	3.7e-07	5.0	-5.3	1.2e-07	-0.57	0.35	0.64	FALSE
9	GTEx	Thyroid	SSH2	0.12	0.17	enet	10	0.18	2.0e-13	5.0	-5.3	1.2e-07	-0.55	0.91	0.09	FALSE
10	GTEx	Thyroid	CORO6	0.23	0.36	lasso	5	0.37	1.2e-29	5.0	-5.3	1.2e-07	-0.61	0.79	0.21	FALSE
11	GTEx	Thyroid	ANKRD13B	0.23	0.12	lasso	6	0.18	2.3e-13	-5.0	-6.4	1.5e-10	-0.44	0.61	0.39	TRUE
12	METSIM	Adipose	SSH2	0.03	0.03	blup	422	0.02	1.5e-04	5.6	-5.3	1.0e-07	-0.55	0.41	0.59	FALSE
13	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	EFCAB5	0.06	0.08	lasso	2	0.07	1.4e-06	-5.4	-5.8	5.0e-09	-0.68	0.07	0.93	FALSE
14	The Cancer Genome Atlas	Breast Invasive Carcinoma	EFCAB5	0.02	0.04	lasso	4	0.04	1.9e-08	-5.4	-5.5	4.0e-08	-0.54	0.08	0.92	FALSE
15	The Cancer Genome Atlas	Breast Invasive Carcinoma	SSH2	0.01	0.01	blup	111	0.01	1.0e-03	5.5	-5.4	7.4e-08	-0.50	0.10	0.87	FALSE
16	The Cancer Genome Atlas	Colon Adenocarcinoma	CCDC55	0.15	0.01	blup	64	0.04	1.9e-03	-6.1	6.3	3.1e-10	0.72	0.02	0.57	FALSE
17	The Cancer Genome Atlas	Colon Adenocarcinoma	EFCAB5	0.06	0.05	blup	79	0.03	5.7e-03	-5.4	-5.6	2.1e-08	-0.56	0.05	0.91	FALSE
18	The Cancer Genome Atlas	Esophageal Carcinoma	CCDC55	0.27	0.00	blup	64	0.00	3.5e-01	-1.2	6.3	3.4e-10	0.89	0.01	0.32	FALSE
19	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	EFCAB5	0.09	0.12	lasso	5	0.12	3.1e-13	-5.4	-5.3	1.5e-07	-0.50	0.19	0.81	FALSE
20	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	SSH2	0.03	0.02	blup	112	0.03	2.4e-04	-5.2	-5.2	2.0e-07	-0.55	0.22	0.74	FALSE
21	The Cancer Genome Atlas	Brain Lower Grade Glioma	EFCAB5	0.07	0.09	enet	16	0.08	4.0e-09	-5.5	-5.1	2.7e-07	-0.47	0.04	0.96	FALSE
22	The Cancer Genome Atlas	Lung Adenocarcinoma	EFCAB5	0.06	0.09	lasso	1	0.09	2.9e-10	-5.3	-5.3	1.4e-07	-0.50	0.26	0.74	FALSE
23	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	EFCAB5	0.04	0.04	lasso	4	0.05	5.9e-06	-5.7	-6.0	1.7e-09	-0.59	0.05	0.95	FALSE
24	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	EFCAB5	0.08	0.01	blup	79	0.03	1.7e-02	-5.9	-5.1	2.8e-07	-0.51	0.04	0.64	FALSE
25	The Cancer Genome Atlas	Prostate Adenocarcinoma	EFCAB5	0.04	0.03	enet	10	0.02	6.0e-03	-5.5	-5.6	1.7e-08	-0.68	0.04	0.92	FALSE
26	The Cancer Genome Atlas	Soft Tissue Sarcoma	EFCAB5	0.06	0.07	lasso	2	0.05	8.2e-04	-5.4	-5.5	3.1e-08	-0.56	0.07	0.91	FALSE
27	The Cancer Genome Atlas	Thyroid Carcinoma	EFCAB5	0.11	0.18	enet	13	0.20	5.8e-19	-5.4	-5.9	2.9e-09	-0.58	0.08	0.92	FALSE
28	The Cancer Genome Atlas	Thyroid Carcinoma	GIT1	0.06	0.05	blup	47	0.05	5.2e-06	5.0	-5.9	4.2e-09	-0.48	0.02	0.97	FALSE
29	The Cancer Genome Atlas	Thyroid Carcinoma	SLC6A4	0.02	0.03	lasso	3	0.03	2.8e-04	-5.7	5.5	3.4e-08	0.62	0.05	0.40	FALSE
30	The Cancer Genome Atlas	Thyroid Carcinoma	SSH2	0.25	0.18	lasso	5	0.17	4.8e-16	5.0	-5.2	2.5e-07	-0.56	0.74	0.26	FALSE