TWAS
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Genes
Traits
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Traits
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BMI
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chr17:73,059,836-74,629,867
Best TWAS P=2.32e-08 · Best GWAS P=1.35e-07 conditioned to 0.326
73M
73.2M
73.4M
73.6M
73.8M
74M
74.2M
74.4M
74.6M
0
2
4
6
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
2
GTEx
Brain Hypothalamus
TRIM65
0.26
0.09
lasso
7
0.12
9.7e-04
4.8
5.6
2.3e-08
0.85
0.02
0.71
TRUE
4
GTEx
Lung
RP11-552F3.10
0.12
0.02
lasso
2
0.03
4.4e-03
5.3
-5.5
3.8e-08
-0.96
0.02
0.53
FALSE
5
YFS
Blood
GALK1
0.05
0.04
enet
26
0.04
2.4e-13
5.2
-5.4
8.5e-08
-0.63
0.00
0.99
FALSE
3
GTEx
Breast Mammary Tissue (Female)
FBF1
0.14
0.13
lasso
3
0.13
1.2e-04
4.8
5.3
1.4e-07
0.82
0.04
0.67
FALSE
1
GTEx
Brain Cerebellum
TRIM47
0.30
0.17
lasso
2
0.17
1.1e-05
5.2
-5.1
2.8e-07
-0.97
0.01
0.97
FALSE