Best TWAS P=1.04e-19 · Best GWAS P=2.29e-20 conditioned to 0.287
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Artery Tibial | STRA13 | 0.37 | 0.22 | enet | 14 | 0.22 | 1.6e-17 | 4.7 | -5.2 | 2.0e-07 | -0.07 | 0.23 | 0.76 | TRUE |
| 2 | GTEx | Artery Tibial | CCDC57 | 0.08 | 0.03 | enet | 7 | 0.05 | 5.8e-05 | 4.9 | -5.8 | 5.8e-09 | 0.14 | 0.05 | 0.93 | TRUE |
| 3 | GTEx | Artery Tibial | BAIAP2-AS1 | 0.09 | 0.04 | lasso | 3 | 0.04 | 5.9e-04 | 7.2 | 6.8 | 1.3e-11 | -0.56 | 0.08 | 0.73 | FALSE |
| 4 | GTEx | Brain Cerebellar Hemisphere | BAIAP2 | 0.36 | 0.01 | enet | 22 | 0.02 | 8.5e-02 | 6.3 | -9.1 | 1.0e-19 | 0.43 | 0.04 | 0.14 | TRUE |
| 5 | GTEx | Brain Cerebellum | CCDC57 | 0.40 | 0.44 | lasso | 21 | 0.42 | 7.1e-14 | 5.1 | -5.2 | 2.5e-07 | 0.15 | 0.04 | 0.96 | FALSE |
| 6 | GTEx | Esophagus Mucosa | CCDC57 | 0.13 | 0.10 | lasso | 2 | 0.08 | 2.9e-06 | 5.1 | -5.2 | 1.9e-07 | 0.15 | 0.04 | 0.96 | FALSE |
| 7 | GTEx | Esophagus Mucosa | RP11-1376P16.2 | 0.06 | 0.04 | lasso | 9 | 0.00 | 1.5e-01 | 5.2 | -5.2 | 2.6e-07 | 0.14 | 0.04 | 0.88 | FALSE |
| 8 | GTEx | Lung | CCDC57 | 0.11 | 0.08 | enet | 18 | 0.05 | 8.4e-05 | -5.2 | -5.2 | 1.6e-07 | 0.13 | 0.04 | 0.96 | FALSE |
| 9 | GTEx | Muscle Skeletal | RPTOR | 0.14 | 0.05 | enet | 27 | 0.09 | 8.4e-09 | -7.1 | -8.9 | 4.0e-19 | 0.62 | 0.62 | 0.37 | TRUE |
| 10 | GTEx | Muscle Skeletal | CTD-2561B21.4 | 0.06 | 0.04 | lasso | 7 | 0.03 | 2.3e-04 | -7.1 | -8.1 | 3.8e-16 | 0.64 | 0.16 | 0.76 | FALSE |
| 11 | GTEx | Nerve Tibial | EIF4A3 | 0.09 | 0.01 | lasso | 4 | 0.01 | 7.8e-02 | -6.2 | 5.2 | 2.5e-07 | -0.50 | 0.06 | 0.56 | FALSE |
| 12 | GTEx | Prostate | CARD14 | 0.24 | 0.00 | enet | 23 | 0.01 | 2.0e-01 | -9.1 | -6.5 | 6.5e-11 | 0.59 | 0.03 | 0.62 | FALSE |
| 13 | GTEx | Prostate | CCDC57 | 0.20 | 0.17 | lasso | 3 | 0.15 | 1.6e-04 | -4.2 | -5.1 | 3.0e-07 | 0.15 | 0.04 | 0.88 | FALSE |
| 14 | GTEx | Skin Not Sun Exposed Suprapubic | RPTOR | 0.25 | 0.12 | lasso | 7 | 0.24 | 1.6e-13 | -4.3 | 5.7 | 9.3e-09 | -0.73 | 0.15 | 0.85 | FALSE |
| 15 | GTEx | Skin Not Sun Exposed Suprapubic | CTD-2561B21.4 | 0.19 | 0.06 | enet | 13 | 0.11 | 2.1e-06 | 4.5 | 5.4 | 5.5e-08 | -0.56 | 0.94 | 0.05 | FALSE |
| 16 | GTEx | Skin Sun Exposed Lower leg | RPTOR | 0.29 | 0.27 | lasso | 5 | 0.30 | 1.6e-25 | -4.3 | 6.4 | 1.7e-10 | -0.73 | 1.00 | 0.00 | FALSE |
| 17 | GTEx | Skin Sun Exposed Lower leg | CTD-2561B21.4 | 0.10 | 0.09 | enet | 8 | 0.10 | 2.6e-08 | -4.3 | 6.6 | 4.2e-11 | -0.78 | 0.08 | 0.92 | FALSE |
| 18 | GTEx | Stomach | CCDC57 | 0.11 | 0.09 | lasso | 3 | 0.10 | 2.0e-05 | -5.2 | -5.2 | 1.5e-07 | 0.14 | 0.04 | 0.94 | FALSE |
| 19 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | NPTX1 | 0.06 | 0.04 | lasso | 1 | 0.03 | 7.4e-05 | -6.0 | 6.0 | 2.7e-09 | -0.54 | 0.46 | 0.35 | FALSE |
| 20 | The Cancer Genome Atlas | Thyroid Carcinoma | RPTOR | 0.09 | 0.00 | blup | 267 | 0.04 | 2.0e-04 | 7.2 | 5.8 | 6.9e-09 | -0.44 | 0.10 | 0.18 | FALSE |