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chr21:39,849,553-41,419,624

Best TWAS P=1.47e-10 · Best GWAS P=2.03e-11 conditioned to 0.173

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	BRWD1	0.12	0.15	lasso	8	0.15	1.1e-17	-5.5	5.6	1.7e-08	0.56	0.72	0.28	FALSE
2	CommonMind	Brain Pre-frontal Cortex	PSMG1	0.19	0.24	enet	30	0.26	2.0e-31	4.6	5.4	6.7e-08	0.84	0.98	0.02	FALSE
3	GTEx	Adipose Subcutaneous	PSMG1	0.19	0.12	enet	26	0.13	4.1e-11	-5.8	5.8	5.2e-09	0.72	0.40	0.60	FALSE
4	GTEx	Adipose Visceral Omentum	BRWD1-IT2	0.13	0.01	lasso	3	0.02	2.4e-02	-5.5	-5.7	1.4e-08	-0.59	0.31	0.59	FALSE
5	GTEx	Artery Aorta	PSMG1	0.13	0.08	lasso	2	0.04	3.6e-03	-5.2	5.2	1.6e-07	0.70	0.31	0.12	FALSE
6	GTEx	Brain Hypothalamus	PSMG1	0.46	0.20	lasso	5	0.16	1.5e-04	4.8	5.3	1.2e-07	0.81	0.08	0.88	FALSE
7	GTEx	Breast Mammary Tissue	PSMG1	0.28	0.26	lasso	4	0.23	5.2e-12	-5.7	5.8	7.7e-09	0.64	0.38	0.62	FALSE
8	GTEx	Breast Mammary Tissue (Female)	PSMG1	0.14	0.09	lasso	11	0.07	3.3e-03	-5.7	6.1	9.3e-10	0.64	0.14	0.57	FALSE
9	GTEx	Colon Transverse	PSMG1	0.23	0.19	lasso	5	0.22	1.4e-10	4.8	5.6	2.6e-08	0.82	0.70	0.30	FALSE
10	GTEx	Esophagus Mucosa	PSMG1	0.37	0.38	lasso	5	0.37	6.4e-26	-5.5	5.5	3.1e-08	0.59	0.48	0.52	FALSE
11	GTEx	Esophagus Mucosa	HMGN1	0.11	0.08	lasso	4	0.07	2.6e-05	-4.8	5.4	8.0e-08	0.66	0.59	0.34	FALSE
12	GTEx	Esophagus Mucosa	BRWD1-IT2	0.08	0.06	lasso	5	0.06	3.9e-05	-5.3	-6.4	1.5e-10	-0.88	0.04	0.95	TRUE
13	GTEx	Esophagus Muscularis	PSMG1	0.15	0.10	lasso	4	0.07	3.9e-05	-5.2	5.2	1.6e-07	0.70	0.71	0.27	FALSE
14	GTEx	Heart Atrial Appendage	PSMG1	0.14	0.12	lasso	2	0.10	2.2e-05	-5.2	5.2	1.6e-07	0.70	0.48	0.40	FALSE
15	GTEx	Lung	PSMG1	0.12	0.13	lasso	5	0.12	3.4e-09	-5.5	5.9	4.6e-09	0.78	0.47	0.53	FALSE
16	GTEx	Muscle Skeletal	PSMG1	0.13	0.16	enet	15	0.19	7.1e-18	-4.8	5.5	4.3e-08	0.81	0.81	0.19	FALSE
17	GTEx	Skin Not Sun Exposed Suprapubic	PSMG1	0.26	0.34	lasso	5	0.34	2.1e-19	-5.7	5.4	5.8e-08	0.50	0.46	0.54	FALSE
18	GTEx	Skin Sun Exposed Lower leg	PSMG1	0.32	0.38	lasso	3	0.38	5.5e-33	-5.7	5.7	1.4e-08	0.58	0.45	0.55	FALSE
19	GTEx	Skin Sun Exposed Lower leg	BRWD1	0.09	0.05	lasso	8	0.04	4.9e-04	-5.6	6.3	3.9e-10	0.58	0.08	0.79	FALSE
20	GTEx	Stomach	BRWD1-IT2	0.16	0.10	enet	13	0.07	3.4e-04	-6.0	-5.2	1.7e-07	-0.34	0.10	0.54	TRUE
21	GTEx	Testis	HMGN1	0.21	0.22	lasso	3	0.21	9.7e-10	-4.8	5.1	2.8e-07	0.71	0.85	0.15	FALSE
22	GTEx	Vagina	PSMG1	0.40	0.16	lasso	8	0.20	2.1e-05	4.8	6.2	5.4e-10	0.74	0.15	0.70	FALSE
23	METSIM	Adipose	PSMG1	0.05	0.01	bslmm	638	0.02	3.6e-04	6.7	6.0	1.7e-09	0.78	0.02	0.98	FALSE
24	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	HMGN1	0.07	0.12	lasso	5	0.09	6.2e-08	-4.8	5.1	3.0e-07	0.68	0.22	0.78	FALSE
25	The Cancer Genome Atlas	Breast Invasive Carcinoma	HMGN1	0.04	0.05	lasso	4	0.05	5.9e-10	-4.8	5.2	2.5e-07	0.70	0.25	0.75	FALSE
26	The Cancer Genome Atlas	Breast Invasive Carcinoma	PSMG1	0.05	0.09	lasso	4	0.08	1.7e-16	-5.5	5.6	1.9e-08	0.62	0.01	0.99	FALSE
27	The Cancer Genome Atlas	Colon Adenocarcinoma	PSMG1	0.09	0.05	lasso	2	0.03	6.5e-03	-5.2	5.2	2.6e-07	0.70	0.02	0.64	FALSE
28	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	PSMG1	0.04	0.04	lasso	2	0.03	2.5e-04	-5.2	5.2	1.6e-07	0.70	0.04	0.87	FALSE
29	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	PSMG1	0.08	0.07	lasso	4	0.06	1.4e-07	4.7	5.6	2.1e-08	0.86	0.16	0.84	FALSE
30	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	HMGN1	0.12	0.12	enet	7	0.12	1.9e-06	-5.4	5.4	7.2e-08	0.64	0.02	0.98	FALSE
31	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	PSMG1	0.07	0.07	blup	61	0.04	6.3e-03	-4.8	5.6	2.4e-08	0.76	0.02	0.87	FALSE
32	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	PSMG1	0.04	0.04	blup	61	0.04	2.1e-05	4.7	5.7	1.4e-08	0.82	0.03	0.96	FALSE
33	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	PSMG1	0.11	0.10	blup	61	0.08	2.2e-04	-5.7	5.2	2.4e-07	0.74	0.02	0.96	FALSE
34	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	HMGN1	0.12	0.13	lasso	4	0.12	2.2e-05	-5.8	5.6	2.6e-08	0.60	0.00	0.98	FALSE
35	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	PSMG1	0.07	0.04	blup	61	0.06	1.7e-03	-3.3	5.8	8.6e-09	0.71	0.02	0.92	FALSE
36	The Cancer Genome Atlas	Stomach Adenocarcinoma	BRWD1	0.04	0.02	blup	97	0.03	2.3e-03	-3.6	5.5	3.3e-08	0.63	0.09	0.18	FALSE
37	The Cancer Genome Atlas	Thyroid Carcinoma	PSMG1	0.03	0.01	blup	61	0.02	9.1e-03	-5.2	5.8	7.6e-09	0.70	0.02	0.66	FALSE