TWAS hub - PLOD1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Nerve Tibial	0.1351	0.0512	4.9e-03	0.144	NA	0.103	NA	0.138	2.2e-10	NA	9.9e-08	NA	5.3e-10
2	GTEx	Whole Blood	0.1890	0.0360	1.8e-12	0.165	NA	0.196	NA	0.218	5.0e-15	NA	7.5e-18	NA	6.9e-20
3	METSIM	Adipose	0.0461	0.0171	1.0e-03	0.011	0.010	0.019	0.018	0.016	8.0e-03	9.9e-03	6.5e-04	8.6e-04	1.6e-03
4	NTR	Blood	0.0332	0.0101	2.4e-05	0.026	0.016	0.019	0.021	0.024	8.5e-09	5.6e-06	5.9e-07	1.6e-07	1.8e-08
5	ROSMAP	Brain Pre-frontal Cortex	0.1069	0.0313	2.1e-05	0.028	0.055	0.055	0.054	0.045	1.3e-04	1.3e-07	1.4e-07	1.7e-07	1.7e-06
6	YFS	Blood	0.2474	0.0276	0.0e+00	0.305	0.339	0.358	0.344	0.357	6.1e-102	1.5e-115	8.7e-124	8.5e-118	2.4e-123
7	TCGA	Pheochromocytoma and Paraganglioma	0.1540	0.0990	1.6e-03	0.130	0.007	0.061	NA	0.018	7.6e-06	1.7e-01	1.9e-03	NA	6.2e-02

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Blood Platelet Count	9.7	112.6	249.6	-3.9	14.0	5.5	11.4	-2.5	15.8	-12.7
Alcohol intake versus 10 years previously	5.4	8.1	15.7	0.8	4.0	2.0	3.4	2.6	3.9	-1.5
High cholesterol (Self-reported)	4.8	8.5	16.6	-0.4	3.8	2.2	3.6	-0.4	4.1	-3.2
Blood Eosinophil Count	4.2	32.4	65.8	-4.0	8.1	2.7	7.5	3.2	6.4	-5.5
Medication: Cholesterol lowering	3.6	5.5	10.4	1.7	2.2	2.2	2.6	-0.4	2.9	-3.2
Average weekly beer plus cider intake	3.4	5.0	10.3	-0.3	2.8	1.7	2.7	0.4	3.2	-2.5
Ever depressed for a whole week	3.2	4.0	8.1	2.8	-2.3	0.3	-1.4	0.9	-2.0	2.7
Age at First Birth	3.1	4.5	13.0	0.3	2.4	1.1	1.9	-0.4	2.7	-3.6
Medication: Lansoprazole	3.0	3.4	5.0	0.2	2.2	2.2	2.2	1.0	2.1	-1.9
Primary Biliary Cirrhosis	2.8	4.0	8.6	1.0	2.4	1.2	2.9	1.6	2.7	-0.9
Smoking Status	2.8	6.8	12.0	0.6	3.3	3.0	3.5	2.3	3.3	-0.3
Leg fat percentage (right)	2.7	9.9	26.6	1.7	2.0	3.8	3.5	5.2	2.3	1.8
Leg fat percentage (left)	2.7	9.8	26.7	1.5	2.1	3.6	3.4	5.2	2.2	2.3
Fractured/broken bones in last 5 years	2.6	3.4	7.6	0.3	2.8	0.6	2.3	1.6	2.7	-0.3
Migraine (self-reported)	2.5	3.1	5.4	0.3	2.0	1.5	2.2	2.3	2.3	-0.2
Wears glasses or contact lenses	2.5	2.9	6.2	0.8	-2.5	-0.4	-2.4	-1.9	-2.1	0.2
Angina	2.4	3.2	7.2	1.1	1.3	2.7	1.4	1.8	1.6	-2.1
Family relationship satisfaction	2.4	2.9	5.9	-2.0	-1.3	-2.1	-1.6	-2.4	-1.3	0.3
Systolic Blood Pressure	2.3	11.6	60.1	3.6	-0.6	-1.1	-0.7	-7.8	-0.1	-2.5
Medication for cholesterol, blood pressure or diabetes	2.3	3.7	8.0	-2.8	-1.5	-1.7	-2.1	0.9	-2.1	1.9
Leg fat mass (right)	2.3	8.9	22.0	2.4	1.8	3.5	3.2	4.7	2.1	2.0
Smoking status: Previous	2.3	3.4	7.1	0.7	2.4	1.5	2.7	1.2	2.6	-0.1
Friendships satisfaction	2.3	2.9	5.8	-1.4	-1.4	-2.3	-1.7	-2.4	-1.5	0.1
Alcohol drinker status: Previous	2.3	2.6	7.6	1.1	-1.7	-0.8	-1.7	-0.1	-1.7	2.8
Leg fat mass (left)	2.3	8.8	21.7	2.2	1.9	3.4	3.3	4.7	2.2	2.2
Waist circumference	2.2	8.2	18.7	1.6	2.0	3.9	3.0	4.3	2.4	1.5
Past tobacco smoking	2.2	4.0	7.6	-0.6	-2.6	-2.0	-2.8	-1.5	-2.6	0.1
Financial difficulties in last 2 years	2.2	3.0	5.3	0.6	1.8	2.1	2.3	1.8	2.0	-0.6
Illnesses of siblings: Diabetes	2.2	2.8	6.4	0.3	-2.1	-0.6	-2.5	-1.8	-1.9	1.2
Mother’s age at death	2.2	2.8	10.3	-3.2	-1.2	-1.3	-1.7	-0.1	-1.3	-1.2
Chronic bronchitis/emphysema (father)	2.1	2.5	7.0	-0.9	1.6	1.4	1.5	2.6	1.3	1.1
Pulse wave reflection index	2.1	2.6	5.2	1.8	1.7	0.0	1.9	-1.2	2.3	-1.4
Prostate Cancer	2.0	2.8	7.4	1.0	2.4	0.5	2.7	0.4	2.3	-0.1
Hearing difficulty/problems: Yes	2.0	3.1	4.8	-0.2	-2.2	-2.2	-1.9	-1.9	-2.1	-0.2
Body mass index (BMI)	2.0	8.5	23.2	2.0	1.7	3.3	2.9	4.8	1.9	2.4
High blood pressure (siblings)	2.0	2.8	8.8	-0.7	-1.2	-1.7	-1.5	-3.0	-2.0	0.4
Alcohol usually taken with meals	1.9	3.0	7.2	-1.4	-1.4	-1.5	-1.7	-0.7	-2.0	2.7
Gout (self-reported)	1.9	2.6	6.5	0.0	2.2	0.8	2.3	1.1	2.5	-0.6
Angina (self-reported)	1.9	2.5	5.7	1.3	1.1	2.4	1.0	1.5	1.4	-1.9
Ever smoked	1.9	3.3	5.6	1.0	2.3	2.0	2.4	1.6	2.0	0.6
Supplements: Calcium	1.9	2.1	3.9	-0.5	-1.9	-1.4	-2.0	-1.7	-1.4	0.3
Bipolar Disorder (2018)	1.8	2.9	5.8	-0.2	2.4	-0.5	2.4	-1.3	2.0	-1.7
Current tobacco smoking	1.8	3.0	6.1	0.4	2.1	1.9	2.5	1.7	1.7	0.8
Serious illness, injury or assault to yourself	1.8	2.2	9.3	3.1	0.8	0.4	1.6	0.8	1.3	0.9
Medication: Simvastatin	1.8	2.6	4.9	0.5	1.7	2.2	2.2	0.1	2.1	-1.1
Hip circumference	1.8	7.8	28.8	1.4	0.4	3.0	1.6	5.4	0.7	3.4
Father’s age at death	1.8	2.4	5.2	-0.8	-2.1	-0.5	-2.3	0.7	-2.1	1.3
Arm fat mass (right)	1.8	7.3	20.3	1.9	1.5	2.9	2.8	4.5	1.7	2.4
Birth weight of first child	1.8	3.3	8.7	-1.2	-2.3	-0.5	-3.0	1.8	-1.9	0.9
Body fat percentage	1.8	7.3	22.1	1.2	1.5	3.2	2.8	4.7	1.6	2.2
Pulse wave peak to peak time	1.8	2.1	7.3	-2.7	-1.3	-0.5	-1.5	0.7	-1.6	-0.6
Had major operations	1.8	2.1	3.3	0.0	-1.8	-0.7	-1.8	-1.2	-1.7	1.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.8	2.1	3.1	-1.1	1.8	1.5	1.8	-0.2	1.5	-1.6
Smoking status: Current	1.8	2.8	5.5	0.2	2.1	2.1	2.3	1.7	1.7	0.4
Rheumatoid Arthritis	1.7	2.4	5.5	1.0	-1.6	0.1	-0.7	2.2	-1.5	2.4
Other serious medical condition/disability diagnosed by doctor	1.7	2.3	3.8	1.9	-1.8	1.5	-1.1	1.6	-1.3	1.1
Serious illness, injury or assault of a close relative in last 2 years	1.7	2.0	4.3	0.9	-2.1	-1.1	-1.5	-0.4	-2.0	1.0
Wheeze or whistling in the chest in last year	1.7	3.0	6.0	-0.0	2.4	0.8	2.0	2.4	2.0	0.6
Whole body fat mass	1.7	7.0	20.1	1.8	1.3	3.1	2.7	4.5	1.6	2.2
Suffer from ‘nerves’	1.7	2.6	7.3	0.4	-2.7	-0.3	-2.0	-0.9	-2.3	0.9
Arm fat mass (left)	1.7	7.0	18.8	2.0	1.5	2.9	2.8	4.3	1.7	2.2
Illnesses of father: High blood pressure	1.7	2.1	4.5	1.2	-1.5	-1.4	-1.4	-2.1	-1.0	-1.1
Pulse wave Arterial Stiffness index	1.6	1.9	6.0	2.4	1.2	0.3	1.5	-0.7	1.5	0.7
Illness, injury, bereavement, stress in last 2 years	1.6	2.0	7.1	-2.7	0.9	0.7	-0.2	-0.9	0.5	-2.1
Handedness (chirality/laterality): Left-handed	1.6	2.0	5.6	0.1	-1.3	-1.3	-1.3	-0.3	-1.7	2.4
Osteoporosis (self-reported)	1.6	1.9	6.9	-2.6	-1.0	-1.4	-1.2	-0.9	-1.1	-0.2
BMI	1.5	8.6	29.3	2.0	1.1	3.4	2.1	5.4	1.3	2.8
Ever had hysterectomy (womb removed)	1.5	1.7	3.0	-1.7	1.6	-0.1	1.2	-0.6	1.4	-1.7
High blood pressure (mother)	1.5	2.2	10.4	0.4	-1.3	-1.1	-0.9	-3.2	-0.9	-0.3
Illnesses of siblings	1.5	2.1	7.5	0.3	1.3	1.2	1.4	2.7	1.6	-0.2
Arm fat percentage (right)	1.5	6.1	19.7	1.0	1.3	2.6	2.4	4.4	1.2	2.4
Reason for reducing amount of alcohol drunk: Health precaution	1.5	1.7	3.2	0.2	-1.8	-1.1	-1.4	-1.6	-1.7	0.3
Medication: Blood pressure	1.5	2.7	12.1	3.5	1.0	1.2	1.6	-0.6	1.2	-0.2
Arm fat percentage (left)	1.5	6.0	18.2	0.9	1.6	2.6	2.7	4.3	1.5	1.9
Unable to work because of sickness or disability	1.5	1.9	6.0	1.9	-0.0	1.2	0.7	2.5	0.3	1.4
Fasting Glucose	1.4	1.7	3.3	1.4	-1.5	0.7	-1.2	1.2	-0.8	1.8
Trunk fat percentage	1.4	5.6	17.8	0.9	1.1	2.6	2.4	4.2	1.1	2.4
Taking other prescription medications	1.4	2.1	4.5	1.0	1.1	2.1	1.5	1.9	1.3	-1.0
Tinnitus: Yes, but not now, but have in the past	1.4	1.5	5.8	-0.0	0.6	2.4	0.6	1.6	1.0	-0.9
Trunk fat mass	1.4	6.0	17.0	1.5	1.3	2.7	2.6	4.1	1.5	2.3
Chronic bronchitis/emphysema (mother)	1.4	1.6	5.4	-1.0	1.1	-0.3	0.6	-1.4	1.2	-2.3
Heart disease (mother)	1.4	1.7	2.9	-1.2	1.2	1.4	1.4	0.5	1.4	-1.7
Back pain experienced in last month	1.4	2.1	3.8	-0.4	1.3	1.1	1.8	2.0	1.4	1.6
Commuting to job workplace: Cycle	1.4	1.7	3.3	0.5	-1.7	-1.0	-1.8	0.9	-1.8	0.7
Cardiovascular Disease	1.3	4.3	15.9	3.3	-0.4	0.6	0.6	-4.0	0.1	-1.6
Townsend deprivation index at recruitment	1.3	1.9	4.7	0.2	2.2	0.3	2.0	0.4	2.0	-0.2
Medication: Atenolol	1.3	1.6	4.4	2.1	0.7	1.4	1.4	-0.4	1.2	-1.0
Weight	1.3	6.2	15.8	2.1	1.3	2.7	2.5	4.0	1.8	2.3
Impedance of arm (right)	1.3	6.0	9.6	-2.5	-2.6	-2.9	-3.1	-1.4	-3.1	0.4
Falls in the last year	1.3	1.7	5.5	1.8	0.2	1.1	0.3	2.3	0.2	1.5
Depression (self-reported)	1.3	1.6	4.6	1.3	-0.8	1.0	-0.2	1.7	-0.8	2.1
Illnesses of mother	1.3	1.6	4.3	1.2	0.1	1.2	0.3	2.0	-0.2	2.1
Exposure to tobacco smoke at home	1.3	1.4	2.6	1.4	1.1	0.5	1.0	-0.3	1.6	-1.6
Pain type(s) experienced in last month: Hip pain	1.3	1.7	3.1	1.5	1.2	1.3	1.8	0.8	1.6	-0.1
Risk taking	1.3	1.9	6.2	1.5	0.6	1.5	0.9	2.5	1.0	0.6
Lupus	1.2	1.7	3.8	-1.9	1.7	-0.4	1.4	-1.4	1.1	0.4
Ulcerative Colitis	1.2	1.7	5.8	-1.4	1.0	1.0	0.5	-1.0	1.1	-2.4
Eye problems/disorders: Diabetes related eye disease	1.2	1.3	3.5	0.5	-1.9	0.5	-1.9	-0.4	-1.3	-0.4
Medication for hormone replacement therapy	1.2	1.3	4.6	-2.1	-0.4	-1.4	-0.4	-1.2	-0.6	-0.7
Relative age voice broke	1.2	1.9	4.4	0.2	1.1	2.1	0.9	-1.2	1.7	-1.4
High blood pressure	1.2	3.2	18.3	4.3	-0.1	0.6	0.7	-1.9	0.1	0.3
Medication: Levothyroxine sodium	1.2	2.0	9.3	-3.0	0.6	0.6	-0.3	0.7	0.2	-1.7
Hearing difficulty/problems with background noise	1.2	2.0	3.8	-0.0	-1.9	-1.3	-1.9	-1.6	-1.6	-0.3
Had other major operations	1.2	1.4	2.3	0.1	1.1	1.2	1.5	1.5	1.4	1.1
Lung cancer (father)	1.2	1.4	2.9	0.7	1.7	-0.3	1.6	-0.3	1.7	-0.8
Impedance of arm (left)	1.2	5.4	8.0	-2.8	-2.1	-2.8	-2.6	-1.7	-2.7	-0.3
Hypothyroidism/myxoedema (self-reported)	1.2	2.4	10.2	-3.2	1.0	-0.1	-0.1	1.1	0.4	-2.1
Seen a psychiatrist for nerves, anxiety, tension or depression	1.2	1.6	4.9	2.0	-0.7	2.2	-0.1	1.4	-0.1	0.2
Qualifications: College or University degree	1.2	3.9	7.8	-2.6	-2.0	-1.4	-2.8	-1.8	-1.8	-0.5
Eye problems/disorders: None of the above	1.2	1.4	3.1	0.2	1.8	0.3	1.6	1.3	1.4	0.6
Medication: Aspirin	1.2	1.5	3.8	-0.0	1.3	1.9	1.5	-0.1	1.4	-0.9
Hypertension (Self-reported)	1.2	3.2	17.6	4.2	-0.3	0.5	0.5	-2.0	-0.2	0.4
Commuting to job workplace: Walk	1.2	1.3	2.6	1.4	-1.6	-0.0	-1.6	-0.5	-0.9	-0.8
Average weekly champagne plus white wine intake	1.2	1.7	2.7	-1.6	-1.0	-1.5	-0.8	-1.6	-1.5	0.5
Diastolic blood pressure, automated reading	1.2	3.9	8.6	1.8	1.6	0.2	1.9	-2.9	2.0	-2.3
Vascular/heart problems diagnosed by doctor	1.2	3.4	17.8	-4.2	0.0	-0.5	-0.9	2.1	-0.3	0.5
Alzheimer’s Disease (in father)	1.1	1.2	3.5	-1.5	-0.1	-1.9	-0.2	-0.7	-0.8	1.3
Major Depression (MDD)	1.1	1.3	3.1	0.2	-1.7	-0.1	-1.2	0.2	-1.7	1.3
Mean Putamen Volume	1.1	1.2	4.2	-0.7	-0.1	-1.9	-0.2	-2.0	-0.2	0.3
LDL Cholesterol	1.1	1.7	5.8	-1.8	0.2	0.7	0.1	-1.3	0.7	-2.4
Systolic blood pressure, automated reading	1.1	3.1	18.5	1.2	0.3	-0.1	0.2	-4.3	0.4	-1.2
Time employed in main current job	1.1	1.3	2.4	1.3	-0.2	1.5	0.6	1.6	-0.1	1.5
Mouth/teeth dental problems: Bleeding gums	1.1	1.5	3.8	1.9	-1.6	-1.0	-0.9	-1.0	-0.9	-0.7
Medication: Paracetamol	1.1	1.8	5.7	0.1	1.4	1.2	1.3	2.4	1.2	-0.5
Exposure to tobacco smoke outside home	1.1	1.5	3.3	0.8	1.3	-0.4	1.3	1.8	1.0	1.3
Age at first live birth	1.1	1.9	5.7	-0.9	1.3	1.1	0.7	0.2	1.8	-2.4
Medication: Seretide 50 evohaler	1.1	1.3	2.2	-1.2	1.2	0.0	0.9	1.2	1.5	-1.3
Qualifications: NVQ or HND or HNC or equivalent	1.1	1.3	3.4	-1.4	-0.5	-1.3	-0.8	-1.9	-0.6	-0.9
Mouth/teeth dental problems: Mouth ulcers	1.1	1.7	5.2	-0.7	0.8	2.0	0.6	2.3	0.9	0.5
Tinnitus: Yes, now most or all of the time	1.1	1.2	2.6	1.2	-1.6	-0.2	-1.3	-1.1	-0.9	0.9
Age started oral contraceptive pill	1.1	1.3	3.6	-0.4	-1.5	-1.1	-1.9	-0.3	-1.4	0.4
Bipolar Disorder or Schizophrenia	1.0	2.3	4.3	-0.2	1.9	-2.1	1.8	-1.9	1.0	-0.5
Alzheimer’s Disease (including proxy)	1.0	1.5	4.3	-0.9	-0.7	-1.6	-0.6	-0.5	-1.2	2.1
Crohns Disease (2017)	1.0	2.2	6.7	0.1	1.3	1.7	1.1	1.0	1.6	-2.6
Irritable Bowel Disease (IBD)	1.0	2.4	7.7	-0.8	1.4	1.6	1.3	0.4	1.5	-2.8
Body Mass Index (BMI) (2010)	1.0	1.4	2.5	0.9	-1.6	0.4	-1.3	0.8	-1.4	1.4
Frequency of depressed mood in last 2 weeks	1.0	1.4	3.9	2.0	-1.8	1.3	-0.6	0.2	-0.9	-0.1
Frequency of tenseness / restlessness in last 2 weeks	1.0	1.5	3.3	1.3	-1.8	0.9	-1.1	1.4	-1.4	-0.1
Hayfever/allergic rhinitis (self-reported)	1.0	1.3	5.7	-1.1	-0.2	-2.4	-0.1	-0.9	-1.2	0.4
Medication: Amlodipine	1.0	1.4	4.9	2.2	0.2	0.3	0.3	-2.2	0.2	0.3
Health satisfaction	1.0	1.3	3.7	0.9	-0.8	1.1	-0.2	1.4	-0.7	1.9
Medication for pain relief, constipation, heartburn	1.0	1.7	3.2	-0.9	-1.2	-1.8	-1.4	-1.5	-1.3	0.4
Eye problems/disorders: Glaucoma	1.0	1.2	2.8	1.0	-1.4	-0.6	-1.1	-1.7	-1.0	-0.4
Medication: Bendroflumethiazide	1.0	1.5	4.6	1.9	-0.2	1.1	0.4	0.9	-0.3	2.1
Cholesterol lowering medication	1.0	1.5	2.8	-1.7	1.4	1.6	1.2	0.3	1.3	0.1
Blood White Count	0.9	6.8	10.9	0.7	2.9	3.0	2.8	3.3	3.2	-0.8
Number of treatments/medications taken	0.9	1.6	4.0	2.0	0.7	1.7	1.2	0.9	0.9	-0.6
Diabetes (mother)	0.9	1.1	4.6	-2.1	1.0	-0.4	0.8	-0.1	0.5	-1.1
Pain all over the body in last month	0.9	1.0	2.0	1.4	0.7	0.2	1.4	0.7	0.5	1.3
Tense / ‘highly strung’	0.9	1.4	3.1	1.3	-1.1	0.0	-0.3	1.8	-1.2	1.6
Arm fat-free mass (right)	0.9	4.8	6.9	2.6	1.8	2.5	2.6	2.0	2.4	0.6
Medication: Allopurinol	0.9	1.3	2.3	-0.3	1.2	1.5	1.3	1.0	1.5	-0.3
Arm predicted mass (right)	0.9	4.6	6.8	2.5	1.7	2.6	2.5	2.1	2.4	0.7
Overall health rating	0.9	1.9	5.2	1.7	0.1	2.0	0.6	2.3	0.4	0.9
Commuting to job workplace: Car/motor vehicle	0.9	1.1	3.9	0.5	0.4	1.2	0.8	2.0	0.5	0.9
Illnesses of father: Heart disease	0.9	1.3	2.3	1.2	1.1	1.5	1.2	0.4	1.5	-0.4
Loneliness, isolation	0.9	1.2	3.3	1.8	-1.3	0.5	-0.8	1.1	-0.9	0.7
Qualifications: nursing, teaching	0.9	1.4	2.6	-1.1	-1.1	-0.9	-1.5	-0.5	-1.6	1.0
Breast cancer (self-reported)	0.9	1.0	5.0	2.2	-0.8	-0.7	-0.7	-0.4	-0.5	-0.1
Medication: Blood pressure	0.9	1.8	7.7	1.8	-0.8	-0.3	-0.5	-2.8	-0.8	-0.2
Medication: Atorvastatin	0.9	1.1	4.1	-0.0	0.9	0.6	0.9	-0.5	1.3	-2.0
Arm fat-free mass (left)	0.9	4.6	7.6	2.8	1.3	2.4	2.3	2.4	1.9	1.7
Deep venous thrombosis (DVT) (self-reported)	0.9	1.2	2.1	0.1	-1.3	0.1	-1.1	1.1	-1.3	1.4
Maternal smoking around birth	0.8	1.2	2.5	0.1	-1.6	-0.6	-1.5	-1.2	-1.1	-0.6
Qualifications: None of the above	0.8	1.7	4.0	1.5	1.3	1.2	2.0	0.3	1.5	-0.1
Noisy workplace	0.8	1.0	3.0	0.9	-1.7	1.0	-1.0	-0.3	-1.1	-0.1
Medication: Ibuprofen (e.g. Nurofen)	0.8	1.0	1.6	0.5	0.9	1.1	1.2	0.5	1.2	-1.3
Length of working week for main job	0.8	0.8	3.8	-0.1	-0.0	1.2	0.3	1.9	0.2	0.6
Seen doctor (GP) for nerves, anxiety, tension or depression	0.8	1.2	3.9	0.9	-0.3	2.0	0.6	1.6	-0.0	0.8
Birth weight	0.8	1.8	5.3	1.0	-1.3	1.5	-1.2	2.3	-0.5	1.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.8	0.9	3.3	1.0	-0.2	0.1	-0.4	1.8	-0.1	1.3
Osteoarthritis (self-reported)	0.8	1.0	2.6	0.8	0.6	1.6	0.7	1.5	0.2	0.6
Medication: Aspirin	0.8	1.0	3.1	0.1	1.0	1.8	1.1	-0.2	1.2	-0.8
Financial situation satisfaction	0.8	1.0	2.2	0.5	1.1	0.6	1.5	0.6	1.5	-0.5
Medication: Paracetamol	0.8	1.2	5.9	0.2	0.7	0.9	0.8	2.4	0.5	0.3
Arm predicted mass (left)	0.8	4.3	6.6	2.6	1.3	2.3	2.3	2.3	1.9	1.6
Depression (Nagel 2018)	0.7	1.0	3.3	0.8	-1.8	0.6	-0.8	-0.5	-1.1	-0.8
Schizophrenia vs Biploar Disorder	0.7	0.9	2.9	0.3	0.9	0.2	1.3	1.7	1.0	-0.0
Alzheimer’s Disease (in mother)	0.7	0.8	1.7	-0.4	-1.2	-0.1	-1.2	-0.8	-1.3	0.7
Ulcerative Colitis (UC)	0.7	1.2	3.7	-1.0	0.8	1.4	0.8	-0.3	0.9	-1.9
Coronary Artery Disease (CAD)	0.7	0.8	4.0	2.0	-0.5	0.3	0.0	-1.2	-0.1	-0.4
Type 2 Diabetes (T2D) (2012)	0.7	0.8	1.3	-0.1	0.9	0.8	1.1	-1.1	0.6	-1.1
Chronotype (morning person)	0.7	1.6	3.7	0.0	-1.2	-1.9	-1.3	-0.6	-1.1	1.7
Frequency of unenthusiasm / disinterest in last 2 weeks	0.7	0.9	3.3	1.1	-1.8	0.5	-0.6	-0.6	-0.9	-0.6
Nervous feelings	0.7	1.3	2.8	0.5	-1.7	1.2	-0.9	0.6	-1.4	1.0
Hair/balding pattern: Pattern 2	0.7	0.9	2.0	-0.4	1.2	1.2	1.1	1.4	0.3	0.1
Worrier / anxious feelings	0.7	1.3	3.0	1.7	-1.0	1.7	-0.8	1.0	-0.2	-0.5
Prospective memory result	0.7	0.8	3.7	-0.7	0.8	1.9	0.4	-0.2	0.9	-0.3
Medication: Ventolin 100micrograms inhaler	0.7	0.9	2.0	-0.4	1.4	-1.2	1.1	-1.0	0.9	0.1
Supplements: Vitamin C	0.7	0.8	2.2	1.5	-0.0	1.3	0.3	1.1	0.3	0.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.7	1.4	3.2	-0.0	-1.4	-1.4	-1.2	-1.8	-1.2	-0.3
Supplements: Fish oil (including cod liver oil)	0.7	0.9	1.6	-1.2	1.3	0.2	0.9	0.5	1.2	-1.1
Alcohol drinker status: Never	0.7	0.9	2.1	-1.4	0.3	-0.6	0.6	-1.5	0.4	-1.0
Basal metabolic rate	0.7	3.8	6.9	2.1	1.1	2.1	2.0	2.6	1.6	1.7
Schizophrenia (2018)	0.6	1.2	5.2	-0.1	0.5	-2.3	0.4	-1.4	-0.3	0.6
Blood Red Count	0.6	5.7	15.2	-1.4	-1.5	0.4	-1.4	3.9	-1.8	3.9
Hypothyroidism (self reported)	0.6	1.3	4.5	-2.1	0.4	-0.2	-0.2	1.4	0.0	-1.4
Ever used hormone-replacement therapy (HRT)	0.6	0.8	1.6	-1.2	0.5	-1.2	0.2	-0.8	0.3	-1.3
Supplements: Zinc	0.6	0.7	2.1	-0.7	-0.2	-0.4	-0.8	1.2	-0.1	1.4
Severe depression (siblings)	0.6	0.7	1.4	-0.1	-0.8	0.7	-0.8	0.6	-1.0	1.2
Multivitamins +/- minerals	0.6	0.7	2.2	-1.0	0.6	-0.7	0.7	-1.5	0.6	-0.3
Had menopause	0.6	0.8	2.0	-1.4	-0.8	-0.7	-0.9	0.6	-0.8	0.6
Heel bone mineral density (BMD) T-score, automated (right)	0.6	1.3	3.0	0.8	1.2	1.1	1.2	0.8	1.7	-0.9
Medication: Ramipril	0.6	0.8	2.7	1.2	0.0	1.6	-0.0	0.4	0.3	-1.1
Blood clot in the leg (DVT)	0.6	0.8	1.5	-0.1	-1.2	-0.2	-1.2	0.8	-1.2	1.0
Medication: Ibuprofen	0.6	0.7	2.0	0.7	0.4	0.9	0.8	0.3	0.9	-1.4
Long-standing illness, disability or infirmity	0.6	0.9	2.8	1.7	-0.5	1.2	0.1	1.3	-0.1	0.4
Illnesses of father: None of the above (group 1)	0.6	0.7	2.5	-0.7	-0.2	-1.6	-0.6	-0.7	-0.9	0.6
Miserableness	0.6	1.1	2.8	1.1	-0.8	1.7	-0.1	1.7	-0.1	0.3
Basal cell carcinoma (self-reported)	0.6	0.7	4.2	-0.6	-0.2	-0.2	-0.1	-0.7	-0.0	-2.1
Heart attack/myocardial infarction (self-reported)	0.6	0.8	2.7	0.4	-0.0	1.3	0.3	-0.9	0.4	-1.6
Breast Cancer	0.5	1.3	2.6	-1.4	1.4	-1.6	0.8	-0.5	0.9	0.9
HbA1C	0.5	0.6	1.6	0.6	0.6	0.2	0.8	-1.3	0.8	0.5
Neuroticism (2016)	0.5	0.8	2.0	0.8	-1.4	0.8	-0.5	0.3	-1.3	-0.0
Triglycerides	0.5	0.8	2.2	-1.2	-0.6	-0.7	-0.7	-1.5	-0.7	-0.2
Waist Hip Ratio (WHR)	0.5	2.4	4.1	-0.7	1.8	1.0	1.5	-1.5	1.8	-2.0
Medication: Co-codamol	0.5	0.5	1.2	0.4	1.0	0.6	0.6	1.1	0.7	-0.5
Diabetes (father)	0.5	0.6	2.6	-0.1	0.1	0.6	0.1	1.6	-0.0	1.1
Average weekly fortified wine intake	0.5	0.5	2.6	-1.6	0.6	0.2	0.1	-0.9	0.2	0.1
Hayfever, allergic rhinitis or eczema	0.5	1.1	3.4	-1.8	0.3	-0.8	-0.3	-1.0	-0.4	-1.4
Diverticular disease/diverticulitis (self-reported)	0.5	0.6	1.8	0.8	0.2	1.3	0.9	0.5	0.8	0.4
Ever unenthusiastic/disinterested for a whole week	0.5	0.6	3.3	1.8	-0.2	0.1	0.3	0.6	0.1	0.4
Heart attack	0.5	0.6	1.7	0.7	-0.1	1.3	0.2	-0.6	0.2	-1.3
Allergy	0.5	1.1	2.6	1.6	0.1	1.0	0.9	0.9	0.8	1.3
Trunk fat-free mass	0.5	2.8	5.2	2.3	1.0	1.9	1.8	1.7	1.7	0.9
Number of live births	0.5	0.7	1.7	-0.5	-1.2	0.2	-1.3	-0.9	-0.9	-0.0
Happiness	0.5	0.5	1.4	-0.9	-0.5	-1.2	-0.5	-0.8	-0.5	-0.5
Mouth/teeth dental problems: Dentures	0.5	0.8	2.5	0.0	-0.6	-1.6	-0.7	-0.1	-0.9	1.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.5	1.5	3.1	0.2	-1.5	-1.8	-1.0	-0.8	-1.4	1.3
Trunk predicted mass	0.5	2.9	5.4	2.3	1.0	2.0	1.8	1.7	1.8	0.8
Breastfed as a baby	0.5	0.6	2.9	0.2	-0.3	-0.5	-0.4	-1.7	-0.4	-0.6
Loud music exposure frequency	0.5	0.5	1.4	-1.0	0.4	0.1	0.6	0.7	-0.3	1.2
Medication: Omeprazole	0.5	0.6	1.7	-1.0	0.5	1.0	0.6	1.3	0.3	-0.3
Age at last live birth	0.5	0.8	2.3	-1.5	0.3	1.5	0.1	-0.1	0.4	-0.9
Knee pain experienced in last month	0.5	0.8	3.5	0.5	-0.0	1.9	0.8	1.1	-0.0	0.5
Whole body fat-free mass	0.5	2.8	4.1	2.0	1.1	1.7	1.8	1.9	1.6	1.4
Average weekly red wine intake	0.5	0.7	1.8	-0.2	-1.3	-0.5	-1.3	-0.4	-1.0	0.3
Ever had bowel cancer screening	0.5	0.5	1.5	0.2	0.4	1.2	0.2	0.2	0.8	-1.2
Diabetes diagnosed by doctor	0.5	0.8	2.3	0.9	0.5	1.5	0.8	1.0	0.9	-0.1
Eye problems/disorders: Cataract	0.5	0.6	1.4	-1.2	-0.1	-0.3	-0.0	-1.2	-0.1	-1.1
Whole body water mass	0.5	2.7	4.3	2.1	1.1	1.7	1.8	1.8	1.6	1.3
Commuting to job workplace: Public transport	0.5	0.6	1.4	-0.1	-1.1	-0.9	-0.9	0.0	-1.2	0.1
Ever had prostate specific antigen (PSA) test	0.5	0.5	1.6	-1.3	0.4	-0.3	-0.3	-1.3	0.1	-0.5
Pain experienced in last month	0.5	0.8	2.0	-0.0	-0.3	-1.4	-1.1	-1.2	-0.6	-0.9
Heart disease (siblings)	0.5	0.6	2.4	0.8	-0.1	0.8	-0.0	-0.8	0.1	-1.6
Impedance of whole body	0.5	2.7	4.0	-1.9	-1.7	-1.7	-1.9	-1.4	-2.0	-0.6
Intelligence (Savage-Jansen 2018)	0.4	1.2	2.7	-0.8	-0.6	-1.6	-1.1	-1.6	-1.0	-0.5
Reaction Time	0.4	0.8	2.1	1.2	-0.3	-0.1	-0.1	1.4	-0.5	1.4
Ovarian Cancer	0.4	0.5	2.8	-0.4	0.4	-0.3	0.3	-1.7	0.1	-0.4
HDL Cholesterol	0.4	0.7	2.0	-0.5	-0.4	-0.4	-0.7	1.4	-0.7	1.0
Schizophrenia (2014)	0.4	0.8	1.5	-0.4	1.2	-0.9	1.0	-0.9	0.7	-1.0
Type 2 Diabetes (T2D) (2018)	0.4	0.7	1.7	0.5	0.2	1.2	0.8	1.3	0.1	0.6
Relative age of first facial hair	0.4	0.8	2.1	0.1	0.7	0.9	0.5	-0.8	1.0	-1.5
Pack years adult smoking proportion	0.4	0.6	2.7	0.6	-0.0	-1.6	0.2	0.3	-0.4	1.1
Leg fat-free mass (left)	0.4	2.2	4.5	1.4	0.9	1.3	1.5	2.1	1.2	1.7
Supplements: Glucosamine	0.4	0.5	1.0	-0.5	-0.2	-1.0	-0.6	-0.8	-0.9	0.8
Leg predicted mass (left)	0.4	2.3	4.9	1.4	0.9	1.3	1.5	2.2	1.2	1.7
Mouth/teeth dental problems	0.4	0.7	2.2	-0.6	0.7	0.3	0.5	-0.9	0.7	-1.5
Fluid intelligence score	0.4	0.8	3.8	1.1	-0.2	-1.9	-0.3	0.1	-0.6	0.4
Frequency of tiredness / lethargy in last 2 weeks	0.4	0.7	3.0	0.3	-0.2	1.0	0.7	1.7	0.1	-0.1
Qualifications: O levels/GCSEs or equivalent	0.4	0.7	1.8	-0.6	-0.8	-0.8	-1.2	-0.2	-1.3	0.4
Headache pain in last month	0.4	0.7	2.3	-1.2	0.4	0.7	0.1	1.5	0.2	-0.7
Glaucoma (self-reported)	0.4	0.5	2.7	1.6	-0.3	0.5	-0.0	-0.8	0.1	-0.0
Forced vital capacity (FVC), Best measure	0.4	1.5	3.5	-0.1	-1.2	-1.9	-0.8	-1.4	-1.1	1.4
Shortness of breath walking on level ground	0.4	0.5	1.9	1.4	-0.4	-0.1	-0.4	-1.0	0.1	-0.2
Chest pain or discomfort	0.4	0.6	2.0	1.4	0.5	0.7	0.7	0.7	0.5	0.3
Leg fat-free mass (right)	0.4	2.0	4.5	1.4	0.8	1.0	1.2	1.9	1.0	2.1
Ever had stillbirth, spontaneous miscarriage or termination	0.4	0.4	1.8	-1.3	0.8	-0.2	0.5	-0.3	0.2	0.4
Leg predicted mass (right)	0.4	2.1	4.7	1.5	0.8	1.1	1.3	1.9	1.0	2.2
Ever taken oral contraceptive pill	0.4	0.5	2.0	-0.1	0.0	-0.8	-0.5	-1.4	0.2	-0.6
Medication: Lisinopril	0.4	0.5	1.4	-0.8	0.7	-1.2	0.2	-0.9	0.5	-0.2
Number of operations (self-reported)	0.4	0.6	2.8	0.1	-0.4	0.8	0.2	0.9	-0.3	1.7
Irritability	0.4	0.6	1.9	0.0	0.6	1.4	0.7	0.7	0.8	-0.8
Depressed Affect (Nagel 2018)	0.3	0.7	1.7	1.3	-1.0	0.8	-0.1	0.9	-0.7	-0.4
Neuroticism (Nagel 2018)	0.3	0.7	1.9	1.4	-1.0	0.9	-0.0	0.4	-0.4	-0.8
Worry (Nagel 2018)	0.3	0.7	1.5	0.8	-1.2	1.0	-0.5	0.7	-0.9	-0.1
Verbal and Numeric Reasoning (VNR)	0.3	0.7	3.7	0.5	-0.1	-1.9	-0.6	-0.3	-0.5	-0.5
Hand grip strength (left)	0.3	0.7	3.4	0.7	0.3	0.1	0.9	0.5	0.3	1.9
Sensitivity / hurt feelings	0.3	0.6	2.4	0.9	-0.3	-0.9	0.2	-1.6	0.2	-0.1
Fed-up feelings	0.3	0.6	1.4	1.2	-0.4	-0.7	0.4	-0.7	-0.3	-1.1
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.7	1.5	1.0	1.0	-0.5	0.8	-0.2	1.2	-0.9
Qualifications: CSEs or equivalent	0.3	0.4	0.9	0.3	0.9	-0.3	0.9	0.6	0.6	0.3
Neuroticism score	0.3	0.6	2.1	1.5	-1.0	0.7	-0.1	0.2	-0.6	0.4
Hair/balding pattern: Pattern 3	0.3	0.4	1.3	-0.1	-0.3	1.0	-0.7	0.2	0.5	-1.1
Pulse rate	0.3	0.5	1.7	0.6	0.9	-0.2	1.3	-0.1	0.9	0.1
Hair/balding pattern: Pattern 4	0.3	0.7	2.6	-0.6	0.0	-1.2	0.3	-0.5	-0.1	1.6
Ever highly irritable/argumentative for 2 days	0.3	0.4	1.1	0.5	-0.5	0.7	0.1	0.5	-0.5	1.0
Worry too long after embarrassment	0.3	0.4	1.6	1.3	-0.3	0.2	0.6	-0.8	0.2	-0.6
Emphysema/chronic bronchitis	0.3	0.4	1.1	-0.2	0.6	0.4	-0.1	1.1	0.5	-0.8
Neck or shoulder pain in last month	0.3	0.4	1.2	0.8	0.0	1.1	0.5	0.2	0.5	-0.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.3	0.4	1.3	-0.4	-0.4	0.5	-0.6	1.1	-0.3	-0.4
Alcohol intake frequency.	0.3	0.6	1.4	-1.2	0.2	-1.2	0.1	0.3	-0.4	1.1
Leg pain on walking	0.3	0.3	1.0	-1.0	0.5	0.6	0.7	0.1	0.5	-0.0
Mood swings	0.3	0.5	1.2	1.1	-1.1	0.3	-0.1	0.3	-0.9	-0.3
Medication for cholesterol	0.3	0.5	2.7	0.2	0.5	-0.1	0.4	1.6	0.6	-0.5
Guilty feelings	0.3	0.5	1.1	1.1	-0.6	0.9	-0.2	0.6	-0.2	-0.8
Hearing aid user	0.3	0.3	1.1	0.1	-0.0	1.1	0.1	1.0	0.3	0.2
Myopia	0.3	0.4	1.4	1.1	0.0	1.2	0.1	0.3	-0.2	0.6
Pack years of smoking	0.3	0.5	1.5	0.9	-0.2	-1.2	0.0	0.5	-0.3	0.8
Crohns Disease (2012)	0.2	0.3	1.5	-0.1	0.1	0.2	0.0	-0.6	0.4	-1.2
Allergy or Eczema	0.2	0.6	1.7	-0.6	-0.3	-0.4	-0.5	-1.1	-0.7	-1.3
Average weekly spirits intake	0.2	0.2	0.7	0.6	-0.2	-0.0	-0.0	-0.7	-0.1	-0.8
Medication: Metformin	0.2	0.3	0.7	-0.2	-0.8	0.6	-0.3	0.4	-0.8	0.2
Bilateral oophorectomy (both ovaries removed)	0.2	0.2	0.5	-0.4	0.5	-0.5	0.7	-0.0	0.3	-0.3
Number of incorrect matches in round	0.2	0.4	1.1	0.3	0.6	0.1	0.5	-0.4	1.0	-0.8
Asthma	0.2	0.4	1.1	-0.5	0.4	-0.9	-0.3	-0.4	-0.2	-1.1
Comparative body size at age 10	0.2	0.5	1.8	-0.7	0.7	0.5	0.4	1.4	0.7	0.3
Number of full brothers	0.2	0.2	0.8	0.9	-0.3	0.7	0.0	-0.3	0.0	0.4
Number of children fathered	0.2	0.3	0.6	0.4	-0.7	-0.4	-0.1	0.4	-0.5	0.8
Mean time to correctly identify matches	0.2	0.4	1.3	1.0	0.1	0.5	0.0	1.1	-0.2	0.7
Comparative height size at age 10	0.2	0.9	4.2	2.1	-0.1	-0.2	0.2	-0.2	0.3	1.3
Number of full sisters	0.2	0.2	1.0	0.2	0.5	-0.1	0.1	1.0	0.1	0.4
Asthma (self-reported)	0.2	0.3	1.2	-0.5	0.6	-0.7	-0.1	-0.4	0.1	-1.1
Medication: Gliclazide	0.2	0.3	0.6	-0.0	-0.8	0.3	-0.5	0.5	-0.7	-0.1
Medication: Omeprazole (e.g. Zanprol)	0.2	0.3	0.8	-0.4	-0.3	0.7	-0.0	0.9	-0.5	-0.2
Respiratory disease	0.1	0.1	0.3	-0.3	0.2	-0.3	-0.4	-0.2	-0.4	-0.6
Lung FEV1/FVC ratio	0.1	0.3	0.6	-0.7	-0.8	0.3	-0.2	0.5	-0.7	0.5
Lung FVC	0.1	0.4	1.2	-0.1	-0.4	-1.1	-0.6	-0.7	-0.4	0.7
Neuroticism	0.1	0.3	1.7	1.3	-0.6	0.2	0.1	-0.3	-0.3	-0.3
Hair Pigment	0.1	1.9	4.7	-0.1	2.0	0.7	1.8	-0.2	2.2	-1.1
Vitamin and mineral supplements	0.1	0.2	0.9	0.7	0.1	-0.1	-0.2	0.9	-0.1	0.1
Impedance of leg (right)	0.1	0.5	2.7	-0.8	-0.3	0.5	0.1	-0.2	-0.1	-1.6
Hand grip strength (right)	0.1	0.3	1.0	-0.3	0.4	-0.7	0.6	-0.4	0.3	1.0
Age when periods started (menarche)	0.1	0.3	1.1	0.5	0.4	-0.4	0.7	-1.1	0.3	0.3
Stomach or abdominal pain in last month	0.1	0.1	0.4	-0.4	-0.2	0.4	0.2	-0.1	-0.2	-0.7
Sitting height	0.1	0.7	2.9	-0.2	-0.7	-1.7	-0.7	-0.6	-0.4	0.8
Forced vital capacity (FVC)	0.1	0.3	1.0	-0.0	-0.0	-0.7	0.1	-0.5	0.0	1.0
Diabetes (self-reported)	0.1	0.1	0.3	0.5	-0.4	0.2	-0.3	0.2	-0.1	0.5
Forced expiratory volume in 1-second (FEV1)	0.1	0.2	0.6	-0.4	-0.3	-0.8	-0.0	-0.6	-0.2	0.4
Qualifications: A levels/AS levels or equivalent	0.1	0.2	0.8	-0.9	0.5	0.0	-0.4	0.1	0.1	0.1
Standing height	0.1	0.9	3.3	0.3	-0.7	-1.3	-0.6	-1.8	-0.2	0.1
Peak expiratory flow (PEF)	0.1	0.2	1.1	-1.1	0.3	0.2	0.3	-0.3	0.1	-0.3
Mouth/teeth dental problems: Loose teeth	0.1	0.2	0.4	-0.4	0.0	0.5	-0.1	-0.6	-0.2	0.6
Pulse rate, automated reading	0.1	0.2	0.8	-0.1	-0.0	-0.3	-0.0	0.9	-0.2	0.8
Forced expiratory volume in 1-second (FEV1), predicted	0.1	0.1	0.5	0.3	0.1	0.0	0.5	0.7	0.1	-0.1
Mineral and other dietary supplements	0.1	0.2	0.8	0.9	-0.3	0.5	0.1	0.1	0.0	0.4
Number of self-reported non-cancer illnesses	0.1	0.2	0.5	-0.4	0.3	0.6	0.7	-0.3	-0.1	-0.4
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Heel T-Score	0.0	0.4	1.3	0.6	0.2	0.2	-0.2	-1.2	0.5	-0.7
Height	0.0	0.4	1.2	1.1	-0.5	0.0	0.2	-0.4	0.5	-1.0
Tanning	0.0	0.6	2.8	1.7	-0.0	0.2	0.2	-0.9	-0.0	0.6
Impedance of leg (left)	0.0	0.2	0.6	-0.7	-0.3	0.3	0.0	-0.2	-0.3	-0.8

Hub : Genes

PLOD1

Models

Trait associations