TWAS hub - C4orf3

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Adipose Subcutaneous	0.1120	0.0480	6.5e-04	0.013	NA	0.013	NA	0.025	2.7e-02	NA	2.7e-02	NA	3.4e-03
2	GTEx	Artery Tibial	0.0353	0.0195	7.9e-03	-0.001	NA	0.027	NA	0.001	3.6e-01	NA	3.2e-03	NA	2.7e-01
3	GTEx	Esophagus Mucosa	0.0740	0.0380	9.9e-03	-0.001	NA	-0.003	NA	-0.002	4.1e-01	NA	5.5e-01	NA	4.4e-01
4	GTEx	Whole Blood	0.1070	0.0320	4.5e-13	0.163	NA	0.152	NA	0.156	6.7e-15	NA	6.8e-14	NA	3.0e-14
5	NTR	Blood	0.0190	0.0088	2.3e-03	0.001	0.009	0.003	0.009	0.001	1.5e-01	5.9e-04	2.6e-02	5.2e-04	9.2e-02
6	ROSMAP	Brain Pre-frontal Cortex	0.0931	0.0314	6.7e-05	0.004	0.032	0.016	0.032	0.011	9.6e-02	5.2e-05	2.8e-03	4.9e-05	1.2e-02

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Impedance of leg (right)	6.5	31.3	86.3	-6.2	-7.3	-3.2	-9.3	-0.4	-0.5
Impedance of leg (left)	6.4	31.0	78.4	-6.3	-7.4	-3.4	-8.9	-0.6	-0.9
Impedance of whole body	5.0	25.4	63.7	-5.2	-7.0	-3.4	-8.0	-0.9	-1.0
Pulse wave reflection index	3.7	4.6	7.2	2.4	1.7	2.7	2.7	2.1	0.6
Age at last live birth	3.7	5.4	12.3	-2.8	-2.1	-2.5	-3.5	-1.1	-0.5
Diastolic blood pressure, automated reading	3.4	10.7	26.8	-5.2	-3.3	-3.8	-3.0	-0.9	-1.6
HDL Cholesterol	3.2	5.3	15.6	-1.5	-2.0	-3.9	-2.3	-2.2	-0.0
Had other major operations	3.1	3.8	8.6	2.2	2.9	1.9	2.3	-0.6	0.6
Qualifications: NVQ or HND or HNC or equivalent	3.0	3.6	8.2	0.7	1.3	1.9	1.9	2.9	2.0
Knee pain experienced in last month	3.0	4.6	7.9	1.3	2.4	2.7	2.8	1.8	1.5
Impedance of arm (left)	2.9	13.3	31.8	-3.2	-5.3	-2.7	-5.6	-1.3	-0.8
Schizophrenia vs Biploar Disorder	2.7	3.6	6.2	-2.5	-1.5	-2.5	-1.7	-0.8	-1.8
Body Mass Index (BMI) (2010)	2.6	3.6	6.4	0.7	2.0	2.0	2.5	2.2	1.3
Blood Platelet Count	2.6	30.0	54.3	-5.8	-7.4	-5.0	-6.9	-3.9	-2.3
Impedance of arm (right)	2.6	12.3	31.3	-2.7	-5.1	-2.7	-5.6	-1.0	-0.3
Angina (self-reported)	2.6	3.5	5.6	-2.1	-2.4	-0.8	-2.3	0.1	-2.3
Supplements: Glucosamine	2.5	3.2	6.8	0.5	0.9	2.1	2.0	1.7	2.6
Neck or shoulder pain in last month	2.5	3.6	6.1	0.8	1.6	2.5	2.3	0.9	2.4
BMI	2.4	14.2	26.3	2.7	4.9	4.6	5.1	2.5	-0.3
Birth weight of first child	2.4	4.4	8.8	0.9	1.9	3.0	3.0	1.7	1.0
Illnesses of father: Heart disease	2.4	3.4	4.9	-1.9	-1.1	-1.8	-1.8	-2.2	-2.0
Average weekly red wine intake	2.4	3.5	6.6	-2.6	-2.0	-1.6	-2.1	-0.2	-1.9
Systolic Blood Pressure	2.3	11.6	33.2	-5.8	-4.4	-2.3	-3.0	-0.3	-1.6
Angina	2.3	3.0	4.7	-2.2	-2.1	-0.5	-2.1	-0.1	-2.1
Heart attack	2.3	2.9	5.4	-2.3	-1.4	-1.2	-1.8	-0.4	-2.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	2.3	2.7	5.0	0.8	2.1	2.2	2.2	1.3	0.0
Wears glasses or contact lenses	2.3	2.7	4.9	1.2	1.0	2.2	2.1	1.9	-0.9
Medication: Atorvastatin	2.3	2.8	5.4	-1.7	-1.7	-2.3	-2.1	-1.1	-0.2
Townsend deprivation index at recruitment	2.1	3.0	5.6	1.4	2.4	2.2	2.1	1.0	-0.3
Diverticular disease/diverticulitis (self-reported)	2.1	2.5	4.4	-0.8	-2.0	-2.1	-1.7	-1.7	-0.5
Glaucoma (self-reported)	2.1	2.5	6.4	-1.2	-0.6	-1.7	-1.5	-1.3	-2.5
Leg predicted mass (right)	2.1	11.1	25.3	3.5	5.0	2.4	4.8	0.4	0.4
Heart attack/myocardial infarction (self-reported)	2.1	2.7	5.1	-2.1	-1.4	-1.3	-1.7	-0.4	-2.3
Alzheimer’s Disease (in mother)	2.0	2.3	4.5	-1.4	-1.4	-2.0	-2.1	-1.1	-0.2
Coronary Artery Disease (CAD)	2.0	2.4	5.0	-1.3	-2.2	-1.2	-1.5	-1.3	-1.6
Blood White Count	2.0	15.1	31.1	-5.6	-5.6	-2.0	-4.9	-0.8	-0.7
Medication: Cholesterol lowering	2.0	3.0	8.1	-1.6	-2.8	-1.5	-2.1	-0.7	-0.8
Medication for cholesterol, blood pressure or diabetes	2.0	3.3	5.8	1.8	2.4	2.0	2.2	0.6	1.3
Age at first live birth	2.0	3.6	9.4	-2.2	-1.9	-1.6	-3.1	-1.3	0.1
Leg fat-free mass (right)	2.0	10.7	24.1	3.4	4.9	2.4	4.7	0.4	0.4
Age at First Birth	1.9	2.8	7.8	-1.7	-1.6	-1.3	-2.8	0.3	-1.3
Leg fat-free mass (left)	1.9	9.9	23.0	3.2	4.8	2.7	4.3	0.7	0.5
Body mass index (BMI)	1.9	8.1	14.7	2.4	3.6	3.4	3.8	1.8	-0.5
Leg predicted mass (left)	1.9	10.2	23.7	3.3	4.9	2.7	4.3	0.7	0.5
Hearing difficulty/problems with background noise	1.9	3.0	5.4	0.8	1.3	1.9	2.1	1.6	-2.3
Eye problems/disorders: Glaucoma	1.9	2.3	3.8	-1.1	-0.8	-1.9	-1.6	-1.4	-1.9
Pain experienced in last month	1.9	3.2	7.5	-1.0	-1.8	-2.2	-2.7	0.8	-1.3
Ever had stillbirth, spontaneous miscarriage or termination	1.8	2.0	3.9	0.9	1.4	-0.4	2.0	-1.7	-1.4
Commuting to job workplace: Walk	1.8	2.0	3.2	-1.3	-1.6	-1.1	-1.1	-1.8	-1.5
Crohns Disease (2012)	1.7	2.7	4.9	-1.4	-2.2	-0.8	-2.0	0.2	-2.1
Alcohol intake versus 10 years previously	1.7	2.5	7.2	2.7	2.0	0.7	1.5	-0.3	1.0
Breastfed as a baby	1.7	2.1	3.9	-0.5	-1.2	-2.0	-0.7	-1.7	-1.9
Heart disease (mother)	1.7	2.0	4.4	-1.4	-2.1	-1.7	-1.3	0.2	1.2
Bipolar Disorder (2011)	1.6	1.6	2.7	-1.6	-1.3	-0.4	-1.4	-0.9	-1.5
Primary Biliary Cirrhosis	1.6	2.2	5.4	-1.0	-2.0	-1.0	-1.4	-2.3	-0.4
Lung FEV1/FVC ratio	1.6	8.2	19.6	-0.4	-2.0	-3.3	-3.5	-4.4	-1.6
Breast cancer (self-reported)	1.6	1.9	3.3	-1.8	-1.2	-1.7	-1.7	-0.8	-0.5
Systolic blood pressure, automated reading	1.5	4.4	12.5	-3.5	-2.6	-1.4	-1.1	0.1	-2.1
Average weekly fortified wine intake	1.5	1.8	4.7	-2.2	-1.4	0.2	-1.5	0.0	-1.2
Waist circumference	1.5	5.3	13.9	1.9	2.4	3.7	2.4	1.7	0.6
Falls in the last year	1.5	2.0	4.9	2.2	1.7	1.0	1.6	0.9	0.3
Medication: Seretide 50 evohaler	1.5	1.7	6.4	-0.4	0.7	1.3	0.7	2.5	0.9
Whole body water mass	1.5	8.7	23.3	2.9	4.8	2.1	4.0	0.6	0.4
Basal cell carcinoma (self-reported)	1.5	1.8	5.7	2.4	0.2	1.4	1.6	0.6	-0.2
Blood clot in the leg (DVT)	1.4	1.8	3.0	-1.7	-1.5	-1.1	-1.7	0.2	-1.2
Medication: Omeprazole	1.4	1.7	3.5	-1.0	-1.2	-1.5	-0.8	-1.2	-1.9
Whole body fat-free mass	1.4	8.3	22.0	2.8	4.7	2.1	3.9	0.6	0.4
Illnesses of father: High blood pressure	1.4	1.7	2.4	-1.5	-1.0	-1.5	-1.1	-1.5	0.9
Commuting to job workplace: Cycle	1.4	1.7	3.0	1.2	1.3	1.4	1.0	1.2	1.7
Arm predicted mass (left)	1.4	7.1	18.7	2.6	4.3	2.5	3.2	0.9	0.3
Trunk predicted mass	1.3	7.2	20.0	2.7	4.5	1.8	3.5	0.4	0.7
Mouth/teeth dental problems: Loose teeth	1.3	1.5	3.9	-1.2	-2.0	-1.0	-1.0	-1.2	-0.4
Back pain experienced in last month	1.3	1.9	4.0	2.0	0.9	1.0	1.8	-1.0	1.1
Arm fat mass (left)	1.3	5.5	11.5	1.6	2.7	3.4	2.7	2.0	-0.7
Basal metabolic rate	1.3	7.4	19.4	2.6	4.4	2.3	3.5	0.7	0.2
Medication: Omeprazole (e.g. Zanprol)	1.3	1.6	3.3	-1.4	-1.8	-1.1	-1.1	-0.6	-1.3
Cardiovascular Disease	1.2	3.8	8.9	-2.7	-3.0	-1.8	-1.6	-0.4	-0.9
Ever used hormone-replacement therapy (HRT)	1.2	1.5	3.2	1.7	-0.3	1.0	1.8	1.2	-0.6
Trunk fat-free mass	1.2	6.9	19.5	2.6	4.4	1.7	3.4	0.3	0.6
Arm fat mass (right)	1.2	5.1	10.4	1.8	2.6	3.2	2.5	1.9	-0.8
Eye problems/disorders: None of the above	1.2	1.4	2.8	0.1	1.4	1.5	1.0	0.5	1.7
Alcohol intake frequency.	1.2	2.9	5.0	1.9	2.2	1.5	1.8	1.5	1.0
Number of self-reported non-cancer illnesses	1.2	2.1	7.6	-1.8	-0.6	-0.7	0.7	-0.2	-2.8
Arm fat-free mass (left)	1.2	6.1	17.5	2.0	4.2	2.2	3.1	0.8	-0.0
Schizophrenia (2014)	1.1	2.4	5.9	-2.4	-1.3	-0.5	-1.0	-0.0	-2.3
Tinnitus: Yes, but not now, but have in the past	1.1	1.2	3.2	1.8	0.3	0.8	-0.3	-1.2	1.4
Medication: Atenolol	1.1	1.4	3.2	-1.1	-1.6	-0.2	-0.8	-0.8	-1.8
Weight	1.1	5.2	11.0	1.9	3.3	2.8	2.6	1.2	-0.4
Tense / ‘highly strung’	1.1	1.7	8.4	0.5	-1.0	0.4	0.9	-0.1	-2.9
Arm fat-free mass (right)	1.1	5.7	15.8	1.7	4.0	2.1	3.2	0.9	0.1
Medication: Blood pressure	1.1	1.9	3.2	-1.2	-1.8	-1.3	-1.7	-0.5	-1.3
Arm predicted mass (right)	1.1	5.5	16.0	1.6	4.0	2.0	3.0	1.0	-0.1
Mood swings	1.1	2.0	4.9	1.1	1.2	2.2	1.6	0.7	-1.1
Illnesses of father: None of the above (group 1)	1.1	1.4	3.9	2.0	0.7	1.1	1.4	0.6	0.7
Number of operations (self-reported)	1.1	1.6	3.4	1.3	1.6	1.4	1.9	-0.2	0.2
Risk taking	1.1	1.6	3.7	1.5	1.2	-1.2	1.0	-1.9	0.4
Bilateral oophorectomy (both ovaries removed)	1.0	1.2	3.3	1.8	0.2	0.5	1.2	-1.4	-0.6
Serious illness, injury or assault to yourself	1.0	1.2	3.9	-0.8	-0.8	-1.2	-0.7	-0.2	2.0
Prospective memory result	1.0	1.2	3.4	0.7	1.2	1.2	1.8	0.1	0.5
Exposure to tobacco smoke outside home	1.0	1.3	2.5	0.5	1.3	1.3	0.7	1.2	-1.6
Wheeze or whistling in the chest in last year	1.0	1.8	7.4	1.1	1.5	0.5	2.7	-0.1	0.3
Leg fat mass (right)	1.0	3.8	10.4	0.4	1.9	3.2	1.2	2.5	-1.0
Pulse rate, automated reading	1.0	3.2	6.8	-1.9	-1.6	-2.6	-1.3	-2.0	0.3
Supplements: Fish oil (including cod liver oil)	1.0	1.4	3.9	-2.0	-1.5	-0.6	-1.0	-0.1	0.7
Medication: Paracetamol	1.0	1.6	3.2	1.6	1.0	0.9	1.4	-1.8	-0.7
Alcohol drinker status: Never	1.0	1.2	4.5	0.6	-0.4	1.4	0.3	2.1	0.7
Fractured/broken bones in last 5 years	1.0	1.3	5.3	0.6	-0.2	-1.3	-0.6	-2.3	0.4
Breast Cancer	0.9	2.2	9.1	-0.3	0.9	1.1	1.0	1.0	3.0
Triglycerides	0.9	1.5	3.4	-0.2	1.1	1.6	1.9	1.3	-0.3
Chronotype (morning person)	0.9	2.0	5.5	1.6	2.4	0.8	1.6	-0.6	0.6
Other serious medical condition/disability diagnosed by doctor	0.9	1.2	3.3	-0.6	0.4	-1.1	0.2	-1.8	-1.5
Eye problems/disorders: Diabetes related eye disease	0.9	1.0	2.3	-0.2	-1.5	-1.1	-1.1	-0.4	1.0
Supplements: Zinc	0.9	0.9	2.7	-0.3	-1.4	-0.2	0.1	-0.9	1.6
Relative age voice broke	0.9	1.4	4.0	-0.4	2.0	1.4	0.4	0.5	1.3
Multivitamins +/- minerals	0.9	1.2	3.0	1.5	1.2	-0.2	0.6	-0.3	1.7
Chronic bronchitis/emphysema (father)	0.9	1.1	2.1	0.7	0.5	0.3	1.4	1.4	1.3
Pain all over the body in last month	0.9	1.0	4.3	0.0	1.0	0.3	0.7	-0.4	-2.1
Arm fat percentage (right)	0.9	3.4	8.0	1.2	1.4	2.8	1.7	2.3	-0.9
Pulse wave peak to peak time	0.9	1.0	4.8	-0.5	-0.8	-0.5	-2.2	0.4	-0.2
Family relationship satisfaction	0.9	1.1	1.6	-0.2	-1.3	-1.2	-1.1	-1.0	-1.1
Medication: Aspirin	0.9	1.2	3.8	-1.3	-1.1	0.3	-0.5	0.4	-1.9
Arm fat percentage (left)	0.9	3.6	8.5	0.9	1.5	2.9	1.9	2.3	-1.1
Ever taken oral contraceptive pill	0.9	1.0	3.3	1.8	-0.5	-0.7	0.2	-1.4	0.5
Financial situation satisfaction	0.9	1.1	2.8	-0.5	-0.2	0.6	-1.0	1.7	1.4
Average weekly beer plus cider intake	0.9	1.3	2.8	0.8	1.7	1.3	1.4	-0.1	0.9
Vascular/heart problems diagnosed by doctor	0.9	2.3	4.4	1.9	2.1	1.4	1.0	0.9	1.6
Deep venous thrombosis (DVT) (self-reported)	0.9	1.2	2.1	-1.5	-1.1	-0.9	-1.4	0.3	-1.1
Pack years of smoking	0.9	1.3	3.5	0.4	0.4	-0.1	1.8	-0.7	-1.9
Leg fat mass (left)	0.9	3.6	9.7	0.4	1.9	3.1	1.4	2.3	-1.1
Depression (Nagel 2018)	0.8	1.2	2.0	-1.1	-1.4	0.9	-1.1	0.4	-1.4
Crohns Disease (2017)	0.8	1.7	3.8	-1.5	-0.8	-0.5	-1.9	0.8	-1.5
Major Depression (MDD)	0.8	1.0	2.3	-1.0	-1.5	-1.2	-0.7	-0.9	-0.1
Fasting Glucose	0.8	1.0	2.5	1.4	0.8	0.5	0.7	0.3	1.6
Ulcerative Colitis	0.8	1.2	4.8	-0.4	0.7	-0.7	0.8	0.6	-2.2
Waist Hip Ratio (WHR)	0.8	3.4	9.8	-0.0	-0.8	3.1	-0.7	0.9	2.9
Vitamin and mineral supplements	0.8	1.1	3.1	-1.8	0.1	-0.1	0.1	1.1	-1.6
Frequency of tiredness / lethargy in last 2 weeks	0.8	1.4	3.2	1.1	0.0	1.8	1.6	-0.8	0.8
Noisy workplace	0.8	1.0	2.2	1.0	-0.6	-0.6	-1.5	-1.3	-0.3
Length of working week for main job	0.8	0.9	2.7	-0.7	0.2	0.7	0.8	1.6	0.9
Mouth/teeth dental problems: Bleeding gums	0.8	1.1	3.1	-1.0	-0.2	0.7	-0.1	-1.4	-1.8
Handedness (chirality/laterality): Left-handed	0.8	0.9	2.1	1.1	1.2	0.2	1.5	-0.8	-0.1
Medication: Aspirin	0.8	1.1	4.0	-1.2	-0.9	0.3	-0.3	0.3	-2.0
Average weekly champagne plus white wine intake	0.8	1.0	2.4	-0.4	-1.3	0.7	-0.4	1.5	1.2
Hearing aid user	0.8	0.9	2.3	-1.0	-1.5	-0.2	0.1	1.0	-1.1
Ever smoked	0.8	1.4	3.2	-0.7	-0.5	1.4	0.1	1.6	-1.8
Irritability	0.8	1.3	3.7	0.9	-0.6	1.9	0.3	0.8	-1.6
Myopia	0.8	1.1	4.0	-0.1	0.2	0.6	-1.4	0.3	-2.0
Alzheimer’s Disease (in father)	0.7	0.8	1.8	1.2	0.7	1.4	0.5	0.6	-0.2
Respiratory disease	0.7	1.5	4.6	-1.3	-0.3	1.1	0.8	2.1	-0.6
Medication: Metformin	0.7	0.9	1.9	-1.2	-1.1	0.4	-0.6	-0.7	1.4
Taking other prescription medications	0.7	1.1	2.3	-1.5	-1.5	-0.1	-0.5	-0.5	-1.3
Heel bone mineral density (BMD) T-score, automated (left)	0.7	1.7	6.2	-1.0	-1.1	0.7	-0.5	2.5	-0.9
Frequency of tenseness / restlessness in last 2 weeks	0.7	1.1	2.6	1.3	0.0	1.6	1.0	1.0	0.4
Fluid intelligence score	0.7	1.4	3.1	-0.9	-1.3	-1.8	-0.3	-1.4	-0.9
Pulse rate	0.7	1.2	3.8	-0.8	0.1	-1.3	-0.3	-2.0	0.8
Lung cancer (father)	0.7	0.8	2.4	0.5	-0.4	-1.2	-0.4	-1.6	-0.7
Ever highly irritable/argumentative for 2 days	0.7	0.8	3.8	0.8	0.4	-0.2	-0.2	-2.0	-0.0
Reason for reducing amount of alcohol drunk: Health precaution	0.7	0.8	2.9	-0.7	-0.3	-0.4	-1.0	0.1	-1.7
Migraine (self-reported)	0.7	0.9	2.9	0.2	0.4	0.3	0.2	-1.7	-1.5
Mean time to correctly identify matches	0.7	1.4	6.9	-0.0	0.9	-0.2	0.2	-0.9	-2.6
Suffer from ‘nerves’	0.7	1.0	2.9	0.2	-0.1	1.7	1.3	0.7	-1.1
Commuting to job workplace: Car/motor vehicle	0.7	0.8	1.5	0.5	1.0	1.0	1.2	1.1	0.2
Depressed Affect (Nagel 2018)	0.6	1.3	4.5	-0.6	-0.5	2.1	0.2	1.3	-1.1
Alzheimer’s Disease (including proxy)	0.6	0.9	2.4	0.2	-0.4	-1.1	-1.5	-1.0	-0.6
Ovarian Cancer	0.6	0.8	1.6	0.1	1.3	0.3	1.0	1.0	-1.0
Number of treatments/medications taken	0.6	1.1	2.3	-0.7	-1.4	-0.4	-0.2	-1.2	-1.5
Pack years adult smoking proportion	0.6	0.9	2.2	0.2	0.6	-0.2	1.5	-0.7	-1.5
Alcohol usually taken with meals	0.6	1.0	2.7	-0.3	-1.7	-0.4	-1.0	0.8	-1.2
Ever unenthusiastic/disinterested for a whole week	0.6	0.7	1.1	-1.1	-0.8	-1.0	-1.0	-0.5	0.3
Qualifications: None of the above	0.6	1.2	4.6	0.7	0.0	-1.2	0.1	-2.1	-0.9
Financial difficulties in last 2 years	0.6	0.9	2.2	-0.7	-0.8	0.5	-1.1	0.7	1.5
Forced expiratory volume in 1-second (FEV1)	0.6	1.9	5.2	-1.7	-0.5	-1.6	-2.3	-0.8	0.1
Qualifications: O levels/GCSEs or equivalent	0.6	0.9	4.3	0.0	0.0	2.1	-0.2	1.0	0.1
Headache pain in last month	0.6	1.0	1.8	0.5	1.2	1.2	1.2	-1.3	0.1
Chronic bronchitis/emphysema (mother)	0.6	0.7	2.8	1.7	0.4	-0.1	1.0	0.4	0.1
Leg fat percentage (right)	0.6	2.3	6.0	-0.8	0.3	2.5	-0.3	2.4	-1.1
Health satisfaction	0.6	0.8	1.4	1.2	-0.6	1.1	0.8	-0.8	0.7
Whole body fat mass	0.6	2.5	6.3	0.3	1.3	2.5	0.9	2.0	-1.4
Leg pain on walking	0.6	0.8	1.8	0.2	1.1	1.3	1.3	0.2	0.1
Illness, injury, bereavement, stress in last 2 years	0.6	0.7	1.9	0.0	0.5	-0.9	0.3	-1.1	-1.4
Qualifications: nursing, teaching	0.6	0.9	1.5	1.2	1.1	0.6	1.0	0.3	1.0
Osteoarthritis (self-reported)	0.6	0.7	2.2	0.5	-0.2	0.8	1.5	-0.3	1.1
Medication: Gliclazide	0.6	0.7	2.7	0.7	-0.3	-0.1	0.7	-1.6	-0.2
Miserableness	0.6	1.0	4.7	0.3	0.5	2.2	0.3	0.8	-0.6
Pain type(s) experienced in last month: Hip pain	0.6	0.8	2.2	0.8	-0.9	-0.3	0.5	-1.5	-0.7
Leg fat percentage (left)	0.6	2.1	5.4	-0.6	0.3	2.3	0.1	2.2	-1.3
Bipolar Disorder or Schizophrenia	0.5	1.2	4.7	-1.5	-0.6	0.1	-0.4	-0.3	-2.2
Neuroticism (Nagel 2018)	0.5	1.2	3.7	-0.0	-0.6	1.9	0.2	0.1	-1.7
Schizophrenia (2018)	0.5	1.0	3.2	-1.4	-0.5	0.3	-0.4	0.6	-1.8
Irritable Bowel Disease (IBD)	0.5	1.1	3.0	-1.3	-0.2	0.1	-0.5	1.2	-1.7
Verbal and Numeric Reasoning (VNR)	0.5	1.1	2.3	-1.1	-1.5	-0.5	-1.0	-0.6	-1.2
Neuroticism (2016)	0.5	0.7	2.1	0.4	-0.2	-0.2	-0.0	-1.3	-1.5
Blood Eosinophil Count	0.5	4.1	8.6	-1.3	1.1	2.9	1.6	2.9	-1.3
Hearing difficulty/problems: Yes	0.5	0.8	2.1	1.5	0.7	-0.2	0.5	0.0	-1.4
Medication for hormone replacement therapy	0.5	0.6	2.9	1.7	0.1	0.3	0.5	-0.3	-0.4
Medication: Co-codamol	0.5	0.5	1.0	1.0	1.0	0.5	0.6	0.4	-0.7
Diabetes (father)	0.5	0.6	1.9	0.6	0.8	1.4	0.0	-0.5	0.7
Diabetes (mother)	0.5	0.7	1.2	0.8	1.0	0.5	1.1	0.9	-0.3
High blood pressure	0.5	1.4	2.8	-1.7	-1.6	-1.1	-0.7	-0.9	-0.8
Sitting height	0.5	3.9	6.9	2.5	2.6	2.0	1.6	0.2	1.8
Trunk fat mass	0.5	2.1	5.2	-0.0	1.0	2.3	0.6	2.0	-1.4
Mouth/teeth dental problems	0.5	0.8	2.0	-0.5	-0.1	-1.1	-1.0	1.4	0.8
Diabetes (self-reported)	0.5	0.8	2.2	-1.5	-1.2	-0.2	-0.9	-0.4	0.0
Neuroticism score	0.5	1.1	4.2	0.3	-0.3	2.1	0.7	0.6	-1.1
Hip circumference	0.5	2.3	5.0	1.3	2.2	1.3	1.7	0.9	-1.2
Happiness	0.5	0.6	2.1	-0.4	-0.6	-0.5	-1.4	-0.7	-0.0
Asthma	0.5	1.0	2.5	-0.3	-0.1	0.9	1.4	1.6	0.7
Depression (self-reported)	0.5	0.6	1.4	0.9	0.5	-0.4	0.4	-1.2	-0.9
Pulse wave Arterial Stiffness index	0.5	0.6	3.0	0.2	0.4	0.2	1.7	-0.7	0.1
Exposure to tobacco smoke at home	0.5	0.6	2.2	-0.1	-1.5	-0.4	-0.6	0.2	-0.9
Loud music exposure frequency	0.5	0.5	1.5	0.3	-0.2	0.7	-0.6	1.2	0.8
Body fat percentage	0.5	2.1	4.8	-0.7	-0.1	2.1	-0.3	2.2	-1.7
Medication: Allopurinol	0.5	0.6	1.5	1.1	-0.6	0.1	1.2	-0.7	0.0
Comparative height size at age 10	0.5	2.7	7.7	0.8	0.1	-2.5	-1.2	-2.8	-0.4
Hypertension (Self-reported)	0.5	1.4	2.5	-1.2	-1.6	-1.3	-0.6	-1.1	-1.1
Friendships satisfaction	0.5	0.6	1.8	-0.5	-0.7	-0.9	-1.3	-0.0	0.7
Mouth/teeth dental problems: Mouth ulcers	0.5	0.8	1.4	-0.4	-1.0	0.6	-1.2	-0.5	-1.2
Asthma (self-reported)	0.5	1.0	3.2	-0.3	-0.1	0.9	1.3	1.8	0.3
Mother’s age at death	0.5	0.6	0.9	0.8	-0.8	1.0	-0.2	0.9	0.7
Bipolar Disorder (2018)	0.4	0.6	1.7	-0.6	-0.3	-0.2	-0.0	-1.3	-1.3
Intelligence (Savage-Jansen 2018)	0.4	1.3	5.7	-0.6	-0.9	0.4	-0.5	0.6	-2.4
Reaction Time	0.4	0.8	2.7	-0.2	1.5	-0.2	0.1	-0.3	-1.6
HbA1C	0.4	0.5	1.3	-0.3	0.9	0.7	0.3	0.1	1.1
Rheumatoid Arthritis	0.4	0.6	2.0	0.3	1.4	0.4	0.8	0.5	0.5
Neuroticism	0.4	1.0	2.5	-0.0	-0.7	1.6	0.7	0.5	-1.5
Trunk fat percentage	0.4	1.7	3.8	-0.7	-0.3	1.9	-0.4	1.9	-1.6
Maternal smoking around birth	0.4	0.6	3.0	-0.2	0.5	-0.4	0.4	-0.3	-1.7
Frequency of unenthusiasm / disinterest in last 2 weeks	0.4	0.6	2.1	-0.5	-0.6	1.5	-0.5	0.8	-0.1
Age when periods started (menarche)	0.4	0.9	3.1	-1.1	-0.7	-0.5	-1.8	0.0	-0.2
Number of incorrect matches in round	0.4	0.6	2.1	0.8	-0.3	-0.8	0.2	-0.5	-1.5
Nervous feelings	0.4	0.7	1.8	-0.8	-1.0	0.5	0.0	-0.8	-1.3
Had menopause	0.4	0.5	1.6	0.3	0.3	0.0	0.7	0.7	-1.3
Heel bone mineral density (BMD) T-score, automated (right)	0.4	0.9	4.5	-0.0	-0.4	0.4	-0.8	2.1	-0.2
Father’s age at death	0.4	0.6	2.5	-0.3	-0.0	0.3	-0.2	1.6	0.8
Number of live births	0.4	0.6	1.2	0.6	1.1	-0.6	1.0	-0.7	-0.6
Medication: Lansoprazole	0.4	0.5	1.2	0.8	0.7	0.1	1.1	-0.2	-0.5
Illnesses of mother	0.4	0.5	1.0	0.7	0.9	0.7	0.5	-0.3	-1.0
Forced expiratory volume in 1-second (FEV1), Best measure	0.4	1.3	3.3	-1.3	-0.3	-1.5	-1.8	-0.7	0.4
Medication: Paracetamol	0.4	0.7	1.3	0.8	0.7	1.0	0.9	-1.1	0.1
Gout (self-reported)	0.4	0.5	1.4	0.3	-1.1	-0.4	0.6	-1.2	0.1
Birth weight	0.4	0.8	2.2	1.0	1.5	0.6	0.2	-1.0	0.6
Medication for pain relief, constipation, heartburn	0.4	0.6	1.0	0.9	0.5	-1.0	-0.2	1.0	0.9
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.4	0.4	1.6	-0.1	0.4	0.5	-0.7	1.2	-0.3
Chest pain or discomfort	0.4	0.5	2.2	0.1	-0.5	-0.5	-0.4	-0.4	-1.5
Supplements: Vitamin C	0.4	0.5	1.3	0.3	-1.0	-0.3	-1.1	-0.6	0.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.4	0.5	1.3	-0.6	-0.4	-0.5	-0.9	0.1	-1.2
Loneliness, isolation	0.4	0.6	1.5	-0.0	-0.6	0.5	-1.1	1.2	-0.5
Long-standing illness, disability or infirmity	0.4	0.5	1.8	-0.7	-1.3	-0.9	-0.0	-0.4	0.0
Ever had bowel cancer screening	0.4	0.4	1.1	1.1	-0.2	-0.1	0.6	-0.8	0.6
Osteoporosis (self-reported)	0.4	0.5	1.3	1.1	0.6	0.8	0.0	0.5	-0.6
Smoking status: Current	0.4	0.7	2.1	0.1	0.9	1.4	0.7	0.6	-0.2
Tinnitus: Yes, now most or all of the time	0.4	0.5	1.4	-0.9	0.1	0.3	0.2	0.8	-1.2
Age started oral contraceptive pill	0.4	0.5	0.9	-0.7	-0.8	0.0	0.5	1.0	-0.9
Heart disease (siblings)	0.4	0.5	0.9	-0.8	-0.7	-0.0	-0.8	-0.8	-0.9
Worry (Nagel 2018)	0.3	0.7	2.0	-0.2	-0.6	1.1	0.8	0.2	-1.4
Prostate Cancer	0.3	0.4	1.4	-0.7	-0.1	0.5	0.7	-0.1	1.2
Mean Putamen Volume	0.3	0.4	1.2	0.0	1.1	0.4	1.0	0.2	-0.1
LDL Cholesterol	0.3	0.4	1.0	0.4	-0.3	0.4	0.5	-1.0	0.8
Heel T-Score	0.3	2.5	10.9	-0.6	0.6	1.5	0.2	3.3	-1.1
Lung FVC	0.3	1.3	3.4	-1.1	0.9	0.8	0.6	1.9	-1.2
Hand grip strength (left)	0.3	0.7	2.0	-0.7	1.0	0.1	-0.1	1.4	-0.8
Sensitivity / hurt feelings	0.3	0.5	1.6	0.4	-0.8	0.6	-0.1	-0.7	-1.3
Severe depression (siblings)	0.3	0.4	1.0	-0.4	0.9	0.3	1.0	0.0	-0.2
Hand grip strength (right)	0.3	0.9	3.4	-0.8	1.8	0.2	0.2	0.5	-0.8
Qualifications: CSEs or equivalent	0.3	0.4	0.8	-0.9	0.6	0.4	-0.1	0.6	0.7
Medication: Levothyroxine sodium	0.3	0.5	0.9	0.9	0.7	0.5	0.8	0.1	0.6
High blood pressure (mother)	0.3	0.4	1.2	0.4	0.4	0.6	0.2	0.5	1.1
Past tobacco smoking	0.3	0.6	1.3	-0.5	-0.4	-1.1	-0.7	-0.8	0.8
Hair/balding pattern: Pattern 2	0.3	0.4	1.3	-0.7	-1.1	0.4	-0.5	0.2	0.5
Forced vital capacity (FVC)	0.3	1.2	4.1	-2.0	-0.3	-0.7	-1.6	0.1	0.3
Allergy	0.3	0.6	1.4	1.0	1.2	0.3	1.0	-0.7	-0.2
Hayfever/allergic rhinitis (self-reported)	0.3	0.4	0.9	0.6	0.6	0.9	0.8	0.2	0.6
Medication: Simvastatin	0.3	0.4	0.9	0.7	-0.9	-0.2	0.1	-0.9	0.4
Time employed in main current job	0.3	0.4	0.8	0.2	-0.6	0.9	-0.7	0.8	0.1
Hair/balding pattern: Pattern 3	0.3	0.5	0.9	0.7	-0.9	0.5	0.6	0.9	-0.3
Serious illness, injury or assault of a close relative in last 2 years	0.3	0.4	0.8	-0.6	-0.5	-0.7	-0.9	0.7	-0.2
Mouth/teeth dental problems: Dentures	0.3	0.5	2.0	0.8	0.6	0.0	1.4	0.2	0.3
Hair/balding pattern: Pattern 4	0.3	0.6	1.3	0.8	-0.1	-0.4	-0.7	1.1	-1.1
Forced vital capacity (FVC), Best measure	0.3	1.0	3.6	-1.9	-0.1	-0.8	-1.2	-0.1	0.2
Worry too long after embarrassment	0.3	0.4	1.2	-0.3	-1.1	1.1	-0.1	-0.2	-0.4
Seen a psychiatrist for nerves, anxiety, tension or depression	0.3	0.4	1.6	0.6	0.4	0.4	1.3	-0.1	-0.2
Number of children fathered	0.3	0.4	0.7	0.5	0.5	0.3	0.5	0.8	0.8
Shortness of breath walking on level ground	0.3	0.4	1.6	-0.4	0.1	-0.5	0.2	-1.3	-0.5
Qualifications: College or University degree	0.3	1.0	1.6	-0.9	-1.3	-1.3	0.0	-1.2	-0.5
Medication: Ibuprofen	0.3	0.3	1.1	0.7	0.2	0.5	0.3	-1.0	0.1
Number of full sisters	0.3	0.4	1.2	0.8	0.6	1.1	0.2	0.5	-0.0
Had major operations	0.3	0.4	1.9	-0.2	0.0	-0.2	0.4	-1.4	-0.1
Forced expiratory volume in 1-second (FEV1), predicted	0.3	0.7	3.3	-0.5	0.6	-0.1	-1.8	-0.1	0.4
Diabetes diagnosed by doctor	0.3	0.5	1.2	-1.0	-1.1	-0.1	-0.8	-0.3	0.1
Guilty feelings	0.3	0.4	1.6	1.3	0.3	0.7	0.2	-0.0	-0.4
Commuting to job workplace: Public transport	0.3	0.3	1.3	-0.3	-1.1	-0.4	-0.5	-0.4	0.1
Medication: Bendroflumethiazide	0.3	0.5	1.7	-0.2	-1.3	-1.0	0.0	-0.5	0.4
Medication: Lisinopril	0.3	0.4	1.3	-1.1	-0.5	-0.3	-0.7	0.3	-0.2
Ever had prostate specific antigen (PSA) test	0.3	0.4	1.8	-0.2	-1.3	-0.4	-0.3	-0.5	0.3
Type 2 Diabetes (T2D) (2012)	0.2	0.2	0.5	0.0	-0.4	-0.7	-0.7	-0.2	0.3
Height	0.2	4.1	10.1	-0.6	-0.6	-1.8	-3.2	-1.6	2.8
Allergy or Eczema	0.2	0.4	1.1	-0.3	-1.1	0.1	-0.7	0.6	-0.7
Hypothyroidism (self reported)	0.2	0.4	1.0	-1.0	-0.6	0.6	-0.0	-0.0	-1.0
Type 2 Diabetes (T2D) (2018)	0.2	0.3	0.7	-0.6	-0.4	0.8	-0.3	0.0	0.8
Average weekly spirits intake	0.2	0.3	1.0	0.7	-1.0	-0.1	0.3	-0.3	-0.3
Relative age of first facial hair	0.2	0.5	1.9	0.2	1.4	0.7	0.7	-0.3	-0.2
Ever had hysterectomy (womb removed)	0.2	0.3	0.7	0.8	-0.0	-0.3	-0.3	-0.1	-0.8
Current tobacco smoking	0.2	0.3	0.8	-0.1	0.6	0.9	0.4	0.4	-0.4
Fed-up feelings	0.2	0.4	0.8	-0.5	-0.7	0.8	0.1	0.0	-0.9
Stomach or abdominal pain in last month	0.2	0.3	0.8	-0.9	-0.5	-0.6	-0.3	-0.1	-0.4
Illnesses of siblings	0.2	0.3	0.9	0.9	0.3	-0.3	0.1	0.1	0.6
Worrier / anxious feelings	0.2	0.4	1.0	-0.2	-0.2	1.0	0.6	0.5	-0.8
Medication: Ibuprofen (e.g. Nurofen)	0.2	0.3	1.1	-0.2	-0.2	0.5	-0.1	-1.0	0.5
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.3	0.7	-0.8	0.3	-0.2	0.7	0.4	0.6
Peak expiratory flow (PEF)	0.2	0.6	1.6	-0.5	0.1	-1.3	-1.0	-0.0	0.7
Medication: Ventolin 100micrograms inhaler	0.2	0.2	0.5	-0.3	-0.5	-0.6	0.7	-0.1	-0.4
High blood pressure (siblings)	0.2	0.3	0.7	-0.5	0.5	0.9	0.3	0.7	-0.2
Number of full brothers	0.2	0.3	0.8	0.4	-0.1	-0.3	-0.9	-0.5	0.6
Overall health rating	0.2	0.4	1.2	-1.0	-0.4	0.1	0.1	-1.1	-0.5
Illnesses of siblings: Diabetes	0.2	0.2	0.6	-0.3	0.7	0.2	0.3	0.4	0.4
Medication for cholesterol	0.2	0.3	0.6	-0.7	0.0	0.8	-0.2	0.6	0.7
Mineral and other dietary supplements	0.2	0.3	1.0	0.4	0.7	-0.4	0.1	-0.3	-1.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.4	1.8	-0.1	0.5	-1.3	-0.4	-0.2	-0.1
High cholesterol (Self-reported)	0.2	0.3	0.7	-0.8	-0.7	-0.7	0.1	-0.3	-0.4
Unable to work because of sickness or disability	0.2	0.2	1.1	-1.0	-0.3	0.5	-0.1	0.2	-0.2
Cholesterol lowering medication	0.2	0.3	0.9	0.4	0.0	-0.1	0.9	-0.6	0.0
Supplements: Calcium	0.2	0.2	0.7	0.8	-0.3	0.2	-0.7	-0.2	0.3
Alcohol drinker status: Previous	0.2	0.2	0.7	0.0	-0.9	-0.5	-0.0	-0.2	-0.1
Ulcerative Colitis (UC)	0.1	0.2	0.4	-0.2	0.1	0.3	0.6	0.6	-0.2
Lupus	0.1	0.2	0.7	-0.1	-0.2	0.2	0.9	0.3	0.4
Smoking Status	0.1	0.3	0.5	0.5	0.7	0.6	0.6	0.1	-0.7
Tanning	0.1	0.9	2.7	-0.0	0.3	0.8	1.6	1.3	0.1
Frequency of depressed mood in last 2 weeks	0.1	0.2	0.5	-0.1	-0.1	0.7	-0.6	-0.3	-0.6
Hayfever, allergic rhinitis or eczema	0.1	0.3	0.6	-0.1	-0.8	-0.2	-0.8	0.5	0.1
Medication: Ramipril	0.1	0.1	0.2	0.2	-0.3	0.1	0.4	0.3	-0.2
Qualifications: A levels/AS levels or equivalent	0.1	0.3	0.7	0.2	-0.8	0.2	-0.5	-0.4	0.7
Standing height	0.1	1.4	5.6	-0.6	-0.2	-0.9	-2.4	-1.2	0.2
Hypothyroidism/myxoedema (self-reported)	0.1	0.3	0.7	0.0	0.3	0.7	0.8	0.5	0.4
Medication: Amlodipine	0.1	0.2	0.7	0.3	-0.3	0.8	-0.3	-0.4	-0.2
Comparative body size at age 10	0.1	0.4	1.0	0.4	0.9	-0.0	0.6	1.0	-0.2
Emphysema/chronic bronchitis	0.1	0.2	0.7	0.1	-0.4	0.8	-0.1	-0.0	0.4
Smoking status: Previous	0.1	0.1	0.4	-0.1	-0.1	0.2	0.3	0.1	-0.6
Eye problems/disorders: Cataract	0.1	0.2	0.4	0.2	-0.3	-0.6	-0.6	-0.2	-0.2
Medication: Blood pressure	0.1	0.2	0.5	-0.4	0.5	-0.6	0.7	-0.1	0.1
Ever depressed for a whole week	0.1	0.1	0.3	-0.5	0.0	-0.0	-0.6	0.0	0.2
Blood Red Count	0.0	0.4	1.8	-0.7	0.1	-0.2	0.2	-0.0	1.4
Hair Pigment	0.0	0.4	1.3	-0.7	0.2	-0.8	-0.2	0.1	-1.1

Hub : Genes

C4orf3

Models

Trait associations