Best TWAS P=3.85e-16 · Best GWAS P=1.45e-14 conditioned to 1.27e-06
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | PCDHGA3 | 0.05 | 0.03 | lasso | 1 | 0.02 | 3.7e-03 | 5.7 | 5.7 | 1.3e-08 | -0.04 | 0.00 | 0.99 | TRUE |
| 2 | GTEx | Colon Transverse | TMCO6 | 0.15 | 0.06 | enet | 16 | 0.05 | 1.4e-03 | 3.3 | -5.2 | 1.8e-07 | -0.09 | 0.19 | 0.48 | TRUE |
| 3 | GTEx | Skin Not Sun Exposed Suprapubic | ZMAT2 | 0.16 | 0.01 | enet | 19 | 0.04 | 1.7e-03 | -4.4 | -5.1 | 3.0e-07 | 0.02 | 0.14 | 0.05 | FALSE |
| 4 | GTEx | Vagina | PURA | 0.52 | 0.05 | enet | 51 | 0.09 | 3.6e-03 | 4.0 | -6.2 | 7.2e-10 | -0.41 | 0.06 | 0.11 | FALSE |
| 5 | ROSMAP | Brain Pre-frontal Cortex | ZMAT2 | 0.03 | 0.02 | bslmm | 185 | 0.02 | 6.5e-04 | -4.3 | -5.2 | 2.6e-07 | -0.06 | 0.64 | 0.21 | FALSE |
| 6 | YFS | Blood | CXXC5 | 0.01 | 0.00 | bslmm | 244 | 0.01 | 2.6e-03 | 6.9 | -8.1 | 3.8e-16 | -0.36 | 0.06 | 0.37 | TRUE |
| 7 | YFS | Blood | HBEGF | 0.02 | 0.02 | lasso | 3 | 0.02 | 9.8e-07 | 5.5 | 5.5 | 5.0e-08 | 0.07 | 0.37 | 0.63 | FALSE |
| 8 | The Cancer Genome Atlas | Brain Lower Grade Glioma | PFDN1 | 0.05 | 0.01 | blup | 47 | 0.01 | 1.9e-02 | -5.4 | 5.3 | 8.7e-08 | 0.09 | 0.01 | 0.86 | FALSE |
| 9 | The Cancer Genome Atlas | Lung Adenocarcinoma | PFDN1 | 0.03 | 0.02 | blup | 47 | 0.02 | 5.5e-03 | -5.3 | 5.2 | 1.8e-07 | 0.06 | 0.04 | 0.53 | FALSE |
| 10 | The Cancer Genome Atlas | Prostate Adenocarcinoma | HBEGF | 0.03 | 0.03 | lasso | 3 | 0.02 | 2.2e-03 | -6.3 | 6.5 | 7.8e-11 | 0.10 | 0.00 | 0.98 | FALSE |