TWAS hub - PCDHGA3

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.053	0.0220	5.5e-03	0.028	0.010	0.004	0.011	0.016	0.00019	1.9e-02	1.0e-01	1.5e-02	3.6e-03
2	GTEx	Prostate	0.312	0.1150	8.0e-03	-0.012	NA	-0.009	NA	-0.011	0.87000	NA	6.4e-01	NA	7.5e-01
3	ROSMAP	Brain Pre-frontal Cortex	0.142	0.0424	2.3e-05	0.017	0.048	0.056	0.066	0.064	0.00280	7.5e-07	9.6e-08	6.5e-09	1.3e-08

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Angina	6.9	9.0	19.9	4.5	1.9	1.8
Angina (self-reported)	6.7	8.8	21.0	4.6	1.7	1.7
Pain type(s) experienced in last month: Hip pain	5.0	6.4	17.6	4.2	1.2	0.0
Financial difficulties in last 2 years	3.7	4.9	9.9	3.1	2.2	0.1
High blood pressure (siblings)	3.7	5.3	9.6	3.1	-0.0	2.5
Exposure to tobacco smoke outside home	3.7	4.9	8.0	2.6	-0.3	2.8
Shortness of breath walking on level ground	3.7	4.4	6.9	2.3	2.6	0.9
Crohns Disease (2017)	3.6	8.0	13.2	3.6	1.9	2.7
Mouth/teeth dental problems	3.4	5.2	14.4	-3.8	-0.9	-0.5
Friendships satisfaction	3.4	4.2	8.3	0.4	-2.9	-2.0
Major Depression (MDD)	3.3	4.0	6.3	-2.5	-1.2	-2.1
Leg fat percentage (left)	3.3	11.9	19.8	4.5	0.2	4.0
Waist circumference	3.2	11.7	18.8	4.3	-0.9	3.9
Leg fat percentage (right)	3.2	11.7	19.3	4.4	0.5	3.9
Mother’s age at death	3.2	3.9	8.9	-1.2	-3.0	1.2
Neuroticism (2016)	2.9	4.2	9.0	1.9	-3.0	0.4
Body mass index (BMI)	2.9	12.3	27.6	5.2	-0.2	3.0
Leg fat mass (right)	2.9	11.3	18.4	4.3	-0.1	3.9
Leg fat mass (left)	2.9	11.4	19.3	4.4	-0.1	3.9
Mouth/teeth dental problems: Bleeding gums	2.8	3.7	8.3	2.9	0.1	1.6
Number of full sisters	2.8	3.4	9.0	3.0	-0.5	0.9
Age at last live birth	2.8	4.0	9.1	-3.0	0.1	-1.7
Medication: Metformin	2.7	3.8	6.3	2.2	0.3	2.5
Irritable Bowel Disease (IBD)	2.5	5.9	9.4	2.5	1.3	3.1
Eye problems/disorders: Diabetes related eye disease	2.5	2.8	5.5	1.3	-2.4	1.0
Fed-up feelings	2.5	4.5	11.8	1.1	-3.4	-0.8
Tinnitus: Yes, but not now, but have in the past	2.5	2.6	3.7	1.7	1.1	1.9
Hayfever/allergic rhinitis (self-reported)	2.5	3.3	9.2	-0.6	-3.0	0.5
Illnesses of siblings	2.5	3.5	7.6	-2.8	-0.4	-1.6
Qualifications: A levels/AS levels or equivalent	2.5	5.5	9.3	-3.0	-2.4	-1.1
Tense / ‘highly strung’	2.5	4.1	6.2	-1.9	-2.5	-1.6
BMI	2.4	13.8	32.4	5.7	-0.7	2.9
Arm fat percentage (right)	2.4	9.7	18.6	4.3	-0.0	3.2
Age at first live birth	2.4	4.3	10.7	-3.3	-1.1	-1.0
Arm fat percentage (left)	2.4	9.4	16.1	4.0	0.0	3.5
Ever unenthusiastic/disinterested for a whole week	2.3	2.8	3.9	-1.9	-1.0	-2.0
Lung cancer (father)	2.3	2.7	5.9	1.5	2.4	0.2
Arm fat mass (right)	2.3	9.4	17.1	4.1	-0.5	3.3
Exposure to tobacco smoke at home	2.3	2.6	3.0	1.6	-1.5	1.7
Body fat percentage	2.3	9.0	13.7	3.6	0.1	3.7
Qualifications: College or University degree	2.2	7.0	15.8	-4.0	-1.7	-1.6
Whole body fat mass	2.2	9.2	13.9	3.7	-0.3	3.7
Mood swings	2.2	4.0	9.6	-0.8	-3.1	-1.3
Arm fat mass (left)	2.2	9.2	16.0	4.0	-0.3	3.4
Trunk fat mass	2.1	8.8	14.7	3.4	-0.3	3.8
Heart attack	2.1	2.7	7.2	2.7	-0.2	0.9
Commuting to job workplace: Walk	2.1	2.3	3.5	-1.9	0.3	-1.8
Crohns Disease (2012)	2.0	3.3	8.4	2.9	0.8	0.9
Supplements: Zinc	2.0	2.2	5.2	-0.8	-2.3	-0.9
Serious illness, injury or assault of a close relative in last 2 years	2.0	2.3	3.9	2.0	-1.1	1.3
Chest pain or discomfort	2.0	2.9	7.0	2.6	-1.1	0.7
Knee pain experienced in last month	2.0	3.1	5.0	2.2	-0.1	2.1
Heart attack/myocardial infarction (self-reported)	2.0	2.6	6.7	2.6	-0.2	1.1
Worry (Nagel 2018)	1.9	4.0	7.8	-2.8	-2.0	-0.3
Frequency of unenthusiasm / disinterest in last 2 weeks	1.9	2.5	4.4	1.1	-1.4	-2.1
Worrier / anxious feelings	1.9	3.5	5.1	-2.3	-2.3	-0.5
Medication: Paracetamol	1.9	3.2	6.3	0.8	-2.5	1.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.9	2.2	5.1	1.2	0.3	2.3
Medication: Paracetamol	1.9	3.0	8.2	0.5	-2.9	0.7
Irritability	1.9	3.2	8.7	-0.8	-2.9	-0.6
Supplements: Calcium	1.9	2.1	3.2	0.0	1.8	-1.7
Body Mass Index (BMI) (2010)	1.8	2.5	5.1	2.3	1.4	0.6
Trunk fat percentage	1.8	7.3	13.0	3.0	0.0	3.6
Number of children fathered	1.8	2.0	5.0	0.8	-0.7	-2.2
Medication: Seretide 50 evohaler	1.8	2.0	3.9	0.9	1.2	2.0
Qualifications: NVQ or HND or HNC or equivalent	1.8	2.2	5.0	2.2	0.9	0.9
Medication: Aspirin	1.8	2.4	5.8	2.4	-0.7	-0.8
Medication for cholesterol	1.8	2.7	4.3	-2.1	1.3	1.5
Guilty feelings	1.8	2.7	6.3	1.1	-0.7	2.5
Weight	1.7	8.4	13.5	3.7	-0.6	3.4
Impedance of arm (left)	1.7	7.7	22.9	-4.8	-0.2	-0.3
Loud music exposure frequency	1.7	1.8	2.8	0.1	1.6	1.7
Overall health rating	1.7	3.6	10.2	3.2	0.6	0.4
Bipolar Disorder (2011)	1.6	1.5	4.4	0.2	2.1	0.4
LDL Cholesterol	1.6	2.5	3.5	1.5	1.9	1.3
Triglycerides	1.6	2.6	5.2	1.1	2.3	-1.1
Blood White Count	1.6	12.0	22.3	4.7	0.9	3.6
Current tobacco smoking	1.6	2.7	7.1	-0.9	0.4	-2.7
Frequency of tenseness / restlessness in last 2 weeks	1.6	2.4	5.1	-0.0	-2.3	-1.5
Peak expiratory flow (PEF)	1.6	3.7	8.2	2.9	-0.1	1.7
Medication: Aspirin	1.6	2.0	5.3	2.3	-0.5	-0.7
Bipolar Disorder (2018)	1.5	2.3	5.2	-2.3	0.1	-1.3
Chronotype (morning person)	1.5	3.4	8.2	-0.9	-1.1	-2.9
Chronic bronchitis/emphysema (father)	1.5	1.7	1.9	1.2	1.3	1.4
Smoking status: Current	1.5	2.4	6.5	-0.7	0.5	-2.5
Ever taken oral contraceptive pill	1.5	1.7	2.3	1.5	1.2	1.1
Myopia	1.5	2.1	5.7	-2.4	0.3	-0.8
Heart disease (siblings)	1.5	1.9	4.4	2.1	0.9	0.7
Vitamin and mineral supplements	1.4	1.8	4.9	-0.5	-0.6	-2.2
Multivitamins +/- minerals	1.4	1.8	5.0	0.7	0.1	2.2
Hip circumference	1.4	6.1	11.4	2.5	-0.8	3.4
Mouth/teeth dental problems: Dentures	1.4	2.4	3.9	2.0	1.7	-0.7
Ever had bowel cancer screening	1.4	1.7	4.0	-0.9	-2.0	-0.4
High cholesterol (Self-reported)	1.4	2.5	4.6	0.8	-1.5	-2.1
Ulcerative Colitis	1.3	1.9	2.5	1.6	-0.8	1.6
Neuroticism	1.3	3.1	6.3	-1.6	-2.5	-0.7
Relative age of first facial hair	1.3	2.7	7.5	0.8	0.1	2.7
Diverticular disease/diverticulitis (self-reported)	1.3	1.5	2.7	-1.6	-0.9	-1.0
Diabetes (self-reported)	1.3	2.0	3.9	2.0	-0.5	1.4
Medication: Ibuprofen (e.g. Nurofen)	1.3	1.7	2.3	1.2	1.5	1.1
Medication: Lansoprazole	1.3	1.5	2.4	-1.6	1.1	-0.9
Birth weight of first child	1.3	2.4	3.6	-1.9	1.6	1.0
Leg pain on walking	1.3	1.6	2.4	1.4	1.6	0.7
Qualifications: nursing, teaching	1.3	2.1	4.5	-2.1	-1.3	0.0
Eye problems/disorders: Cataract	1.3	1.5	2.4	1.5	0.2	1.6
Mineral and other dietary supplements	1.3	1.7	2.8	-0.3	-1.5	-1.7
Ever had prostate specific antigen (PSA) test	1.3	1.5	2.5	0.2	-1.4	-1.6
Impedance of whole body	1.3	6.8	19.9	-4.5	0.3	-0.6
HDL Cholesterol	1.2	2.0	3.1	-1.7	-1.8	-0.3
Number of treatments/medications taken	1.2	2.2	4.5	2.1	1.3	-0.4
Hand grip strength (right)	1.2	3.2	8.6	2.9	1.0	0.2
Neuroticism score	1.2	2.5	6.8	-0.8	-2.6	-0.3
Impedance of arm (right)	1.2	5.7	17.0	-4.1	-0.2	-0.5
Falls in the last year	1.2	1.6	2.0	0.9	-1.4	-1.4
Ever highly irritable/argumentative for 2 days	1.2	1.5	2.6	-1.6	-1.4	-0.1
Emphysema/chronic bronchitis	1.2	1.3	2.5	1.6	1.2	-0.3
Medication for pain relief, constipation, heartburn	1.2	2.1	3.3	-1.8	1.5	-0.9
Diabetes diagnosed by doctor	1.2	1.9	3.0	1.5	-0.7	1.7
Depressed Affect (Nagel 2018)	1.1	2.3	4.5	1.2	-2.1	-1.0
Medication: Co-codamol	1.1	1.2	2.0	0.7	-1.1	1.4
Townsend deprivation index at recruitment	1.1	1.6	2.2	1.3	1.5	-0.9
Relative age voice broke	1.1	1.7	2.6	0.3	1.6	1.6
Supplements: Glucosamine	1.1	1.5	4.0	0.4	-0.5	2.0
Health satisfaction	1.1	1.4	2.1	1.4	0.9	-1.1
Loneliness, isolation	1.1	1.6	4.7	0.1	-2.2	-0.0
Long-standing illness, disability or infirmity	1.1	1.7	3.0	1.7	-0.2	1.5
Number of self-reported non-cancer illnesses	1.1	2.0	4.2	1.3	0.0	2.0
Average weekly beer plus cider intake	1.1	1.6	2.2	1.3	-1.0	1.5
Unable to work because of sickness or disability	1.1	1.4	4.2	2.1	0.2	0.1
Cholesterol lowering medication	1.1	1.6	2.6	1.2	-1.6	-0.9
Basal cell carcinoma (self-reported)	1.1	1.3	1.9	1.2	1.4	0.6
Age at First Birth	1.0	1.4	2.5	-1.6	-1.3	-0.4
Hand grip strength (left)	1.0	2.7	6.5	2.5	1.2	-0.1
Alcohol usually taken with meals	1.0	1.6	2.5	1.6	-0.7	1.4
Nervous feelings	1.0	1.9	2.9	-1.7	-1.1	1.3
Medication: Simvastatin	1.0	1.5	2.8	1.7	-0.7	-1.1
Alcohol intake versus 10 years previously	1.0	1.5	3.7	1.9	0.1	0.9
Hair/balding pattern: Pattern 3	1.0	1.5	2.4	-1.3	0.5	-1.6
Arm fat-free mass (right)	1.0	4.9	7.6	2.8	-1.0	2.5
Illnesses of father: None of the above (group 1)	1.0	1.3	2.3	-1.2	0.2	-1.5
Alcohol drinker status: Never	1.0	1.2	3.0	-1.7	0.7	0.1
Basal metabolic rate	1.0	5.3	7.7	2.8	-0.9	2.7
Ever depressed for a whole week	1.0	1.2	3.2	-0.6	-1.8	-0.2
Depression (Nagel 2018)	0.9	1.4	3.7	0.4	-0.6	-1.9
Alzheimer’s Disease (in father)	0.9	1.0	1.7	-1.0	-1.3	-0.5
Ulcerative Colitis (UC)	0.9	1.7	4.6	0.7	0.1	2.1
HbA1C	0.9	0.9	1.3	1.1	0.6	1.1
Medication for hormone replacement therapy	0.9	1.1	2.1	1.4	0.9	0.4
Medication: Atenolol	0.9	1.1	2.9	1.7	-0.1	0.6
High blood pressure (mother)	0.9	1.3	2.1	-0.3	-1.3	1.4
Medication: Ramipril	0.9	1.2	1.5	1.2	-0.8	1.2
Father’s age at death	0.9	1.2	2.1	-1.4	0.4	1.2
Medication: Cholesterol lowering	0.9	1.5	4.2	2.0	-0.2	-0.4
Illnesses of mother	0.9	1.1	1.8	-1.0	0.6	-1.3
Headache pain in last month	0.9	1.6	4.2	-2.0	-0.3	-0.7
Wheeze or whistling in the chest in last year	0.9	1.6	4.3	2.1	-0.7	0.3
Heart disease (mother)	0.9	1.1	3.0	1.7	-0.6	0.2
Arm predicted mass (right)	0.9	4.9	7.2	2.5	-0.9	2.7
Alcohol intake frequency.	0.9	2.0	4.1	1.4	2.0	0.1
Smoking status: Previous	0.9	1.4	2.1	1.4	-0.5	1.3
Forced expiratory volume in 1-second (FEV1), predicted	0.9	1.9	4.7	-2.2	-0.4	0.9
Mouth/teeth dental problems: Mouth ulcers	0.9	1.4	3.7	1.9	-0.5	0.4
Osteoarthritis (self-reported)	0.9	1.1	3.3	0.3	-0.3	1.8
Arm predicted mass (left)	0.9	4.5	6.8	2.6	-1.0	2.4
Blood Eosinophil Count	0.8	6.0	11.8	3.4	0.8	2.4
Frequency of depressed mood in last 2 weeks	0.8	1.2	2.5	0.0	-1.6	-1.0
Ever used hormone-replacement therapy (HRT)	0.8	1.0	2.1	1.4	0.7	-0.7
Severe depression (siblings)	0.8	0.9	1.6	-1.3	-0.6	-0.9
Leg fat-free mass (left)	0.8	4.3	6.0	2.4	-1.0	2.4
Leg predicted mass (left)	0.8	4.1	5.8	2.4	-0.9	2.4
Happiness	0.8	1.0	1.8	-0.6	-1.4	-0.9
Pulse wave reflection index	0.8	1.0	2.6	0.7	0.1	1.6
Reason for reducing amount of alcohol drunk: Health precaution	0.8	0.9	1.7	1.0	-1.3	0.3
Pulse wave peak to peak time	0.8	0.9	1.5	-1.2	-0.9	-0.7
Family relationship satisfaction	0.8	1.0	1.4	1.0	-1.2	-0.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.8	1.0	1.4	-1.2	-1.0	-0.7
Whole body fat-free mass	0.8	4.5	6.0	2.5	-1.2	2.5
Whole body water mass	0.8	4.8	6.8	2.6	-1.1	2.5
Medication: Blood pressure	0.8	1.5	2.4	1.6	-1.2	-0.9
Medication: Atorvastatin	0.8	1.0	1.9	0.8	-1.4	0.6
Arm fat-free mass (left)	0.8	4.2	6.5	2.5	-1.3	2.1
Number of operations (self-reported)	0.8	1.1	3.0	0.6	0.1	1.7
Vascular/heart problems diagnosed by doctor	0.8	2.2	5.6	-2.4	0.4	-0.9
Blood Platelet Count	0.7	8.1	20.8	4.6	1.7	0.9
Cardiovascular Disease	0.7	2.2	3.5	1.9	-1.7	-0.3
Bilateral oophorectomy (both ovaries removed)	0.7	0.8	2.3	-0.2	1.5	-0.5
Qualifications: CSEs or equivalent	0.7	0.9	2.6	1.6	-0.4	0.2
Serious illness, injury or assault to yourself	0.7	0.8	2.0	0.3	-0.5	-1.4
Past tobacco smoking	0.7	1.2	2.4	-1.5	0.4	-1.0
Seen doctor (GP) for nerves, anxiety, tension or depression	0.7	1.0	2.7	0.5	-1.6	0.4
Migraine (self-reported)	0.7	0.8	2.0	-1.4	-0.7	-0.1
Comparative height size at age 10	0.7	3.6	7.4	-1.8	-2.7	0.4
Commuting to job workplace: Car/motor vehicle	0.7	0.8	1.4	-1.2	0.2	1.0
Hypertension (Self-reported)	0.7	2.0	3.6	1.9	-0.8	1.3
Illnesses of siblings: Diabetes	0.7	0.9	1.9	1.4	0.9	0.1
Leg fat-free mass (right)	0.7	3.7	5.1	2.2	-1.1	2.3
Leg predicted mass (right)	0.7	3.9	5.3	2.3	-1.1	2.3
Hearing aid user	0.7	0.8	2.1	-0.5	-0.3	1.5
Neuroticism (Nagel 2018)	0.6	1.5	4.5	-0.2	-2.1	0.3
Prostate Cancer	0.6	0.8	2.4	0.2	-0.0	1.5
Rheumatoid Arthritis	0.6	0.8	2.1	1.5	-0.5	-0.4
Impedance of leg (right)	0.6	2.7	7.0	-2.6	1.0	0.2
High blood pressure	0.6	1.7	2.8	1.7	-1.1	1.0
Fluid intelligence score	0.6	1.2	3.0	-0.0	-1.7	-0.9
Trunk fat-free mass	0.6	3.6	5.4	2.3	-1.0	2.1
Frequency of tiredness / lethargy in last 2 weeks	0.6	0.9	1.7	1.3	-0.5	-0.9
Prospective memory result	0.6	0.7	2.1	0.1	1.4	-0.3
Pulse wave Arterial Stiffness index	0.6	0.7	1.1	1.0	0.6	0.7
Trunk predicted mass	0.6	3.5	5.0	2.2	-0.9	2.2
Breastfed as a baby	0.6	0.8	1.6	-0.8	-1.3	-0.2
Hair/balding pattern: Pattern 4	0.6	1.5	2.2	1.2	-1.5	0.8
Illness, injury, bereavement, stress in last 2 years	0.6	0.7	1.7	-1.3	0.5	-0.3
Average weekly red wine intake	0.6	0.9	1.1	1.0	-1.1	0.8
Ever had stillbirth, spontaneous miscarriage or termination	0.6	0.6	1.4	0.1	1.2	0.6
Osteoporosis (self-reported)	0.6	0.7	1.1	1.0	0.2	1.0
Average weekly champagne plus white wine intake	0.6	0.8	1.1	0.7	1.1	-0.9
Wears glasses or contact lenses	0.6	0.7	1.7	-0.6	-0.3	-1.3
Financial situation satisfaction	0.6	0.7	1.9	1.4	-0.4	0.3
Tinnitus: Yes, now most or all of the time	0.6	0.7	1.7	-1.3	-0.4	-0.3
Medication: Lisinopril	0.6	0.8	1.6	1.3	-0.7	-0.4
Illnesses of father: High blood pressure	0.6	0.8	1.7	-0.4	-0.7	1.3
Medication: Omeprazole (e.g. Zanprol)	0.6	0.7	1.3	0.7	0.7	1.1
Bipolar Disorder or Schizophrenia	0.5	1.1	2.1	-1.4	-0.6	-1.0
Alzheimer’s Disease (in mother)	0.5	0.6	0.9	0.7	0.6	0.9
Lupus	0.5	0.7	1.1	-0.7	-0.8	-1.0
Schizophrenia (2014)	0.5	1.0	1.3	-1.2	-0.6	-1.1
Allergy or Eczema	0.5	1.3	3.1	-1.8	-0.5	0.8
Type 2 Diabetes (T2D) (2018)	0.5	1.0	2.4	1.6	0.3	0.6
Average weekly fortified wine intake	0.5	0.6	1.1	-1.0	0.1	-0.8
Hayfever, allergic rhinitis or eczema	0.5	1.0	2.2	-1.5	-0.7	0.5
Impedance of leg (left)	0.5	2.6	7.3	-2.7	0.7	0.2
Number of incorrect matches in round	0.5	0.9	2.5	-0.1	-1.6	-0.2
Hearing difficulty/problems with background noise	0.5	0.7	1.3	0.1	-0.9	1.1
Had menopause	0.5	0.6	1.5	0.1	-0.6	-1.2
Qualifications: None of the above	0.5	1.1	3.1	1.8	0.2	0.5
Depression (self-reported)	0.5	0.5	1.1	0.5	-0.4	1.1
Medication for cholesterol, blood pressure or diabetes	0.5	0.8	2.0	-1.4	0.4	0.3
Medication: Amlodipine	0.5	0.8	2.1	-0.3	-1.5	-0.3
Worry too long after embarrassment	0.5	0.9	2.3	-0.1	-0.6	1.5
Eye problems/disorders: None of the above	0.5	0.5	0.8	-0.9	-0.2	-0.8
Medication: Ibuprofen	0.5	0.6	1.1	0.7	1.1	0.3
Medication: Allopurinol	0.5	0.7	1.7	1.3	-0.5	0.3
Schizophrenia vs Biploar Disorder	0.4	0.6	1.0	0.3	-1.0	0.8
Reaction Time	0.4	0.8	2.2	-1.5	0.4	-0.1
Breast Cancer	0.4	1.1	3.1	1.8	0.0	-0.3
Coronary Artery Disease (CAD)	0.4	0.5	0.9	1.0	0.5	-0.5
Type 2 Diabetes (T2D) (2012)	0.4	0.4	1.0	-0.1	-1.0	-0.6
Waist Hip Ratio (WHR)	0.4	1.8	3.8	2.0	-0.9	0.8
Lung FEV1/FVC ratio	0.4	2.1	4.5	2.1	0.2	1.4
Average weekly spirits intake	0.4	0.6	1.1	1.0	-0.0	0.8
Systolic blood pressure, automated reading	0.4	1.1	2.3	1.0	0.3	1.5
Maternal smoking around birth	0.4	0.6	0.8	0.8	-0.6	-0.9
Age when periods started (menarche)	0.4	1.0	1.7	-0.5	1.3	-1.0
Hair/balding pattern: Pattern 2	0.4	0.5	1.2	1.1	0.1	0.5
Heel bone mineral density (BMD) T-score, automated (right)	0.4	1.0	3.0	-0.2	-1.7	-0.3
Time employed in main current job	0.4	0.4	0.8	0.5	0.4	0.9
Pulse rate	0.4	0.7	1.7	0.7	-0.1	-1.3
Standing height	0.4	3.9	9.8	-3.1	-0.9	1.1
Length of working week for main job	0.4	0.4	1.1	0.3	-1.1	0.3
Glaucoma (self-reported)	0.4	0.5	1.1	-0.6	-1.0	-0.1
Gout (self-reported)	0.4	0.6	1.2	0.4	0.6	-1.1
Chronic bronchitis/emphysema (mother)	0.4	0.5	0.9	-0.1	0.8	-0.9
Had major operations	0.4	0.5	1.0	-0.6	-0.2	1.0
Illnesses of father: Heart disease	0.4	0.5	0.8	0.5	-0.7	0.9
Back pain experienced in last month	0.4	0.5	1.2	0.6	0.2	-1.1
Commuting to job workplace: Public transport	0.4	0.5	1.3	1.1	-0.2	-0.3
Age started oral contraceptive pill	0.4	0.5	0.7	-0.9	0.8	0.4
Fasting Glucose	0.3	0.4	0.9	-0.2	-0.9	-0.5
Primary Biliary Cirrhosis	0.3	0.4	1.1	0.0	0.3	-1.1
Smoking Status	0.3	0.8	1.4	1.2	0.3	-1.0
Hearing difficulty/problems: Yes	0.3	0.4	0.6	0.5	0.6	0.8
Other serious medical condition/disability diagnosed by doctor	0.3	0.4	1.0	1.0	-0.1	-0.4
Ever had hysterectomy (womb removed)	0.3	0.3	1.0	0.0	-0.2	-1.0
Pack years adult smoking proportion	0.3	0.4	0.9	-1.0	0.0	-0.6
Sitting height	0.3	2.2	6.2	-2.5	-0.3	-0.6
Had other major operations	0.3	0.4	0.6	0.8	-0.7	0.4
Pain all over the body in last month	0.3	0.3	0.6	0.2	-0.8	-0.5
Blood clot in the leg (DVT)	0.3	0.4	0.7	-0.5	0.8	-0.3
Hypothyroidism/myxoedema (self-reported)	0.3	0.6	1.0	-0.5	-0.7	-1.0
Number of full brothers	0.3	0.3	0.8	0.9	0.2	-0.3
Mouth/teeth dental problems: Loose teeth	0.3	0.4	0.7	0.6	-0.3	-0.8
Medication: Blood pressure	0.3	0.5	0.8	0.9	-0.8	0.3
Suffer from ‘nerves’	0.3	0.4	0.8	-0.9	-0.7	-0.2
Supplements: Vitamin C	0.3	0.3	0.6	0.4	-0.3	0.8
Breast cancer (self-reported)	0.3	0.3	0.7	-0.3	-0.4	0.8
Ovarian Cancer	0.2	0.3	0.6	0.5	0.1	0.8
Mean Putamen Volume	0.2	0.2	0.5	0.4	0.1	0.7
Blood Red Count	0.2	1.5	2.6	0.9	1.0	1.6
Height	0.2	4.1	10.0	-3.2	-0.8	1.4
Hypothyroidism (self reported)	0.2	0.6	1.2	-0.4	-0.5	-1.1
Sensitivity / hurt feelings	0.2	0.4	0.7	0.8	0.4	0.6
Diabetes (mother)	0.2	0.2	0.4	-0.1	-0.5	0.7
Taking other prescription medications	0.2	0.3	0.5	0.7	0.6	0.1
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.6	1.3	0.2	-1.1	-0.6
Allergy	0.2	0.4	0.5	0.7	-0.6	-0.7
Noisy workplace	0.2	0.3	0.5	0.7	0.2	-0.5
Qualifications: O levels/GCSEs or equivalent	0.2	0.4	0.7	-0.9	-0.4	0.4
Medication: Ventolin 100micrograms inhaler	0.2	0.3	0.5	-0.7	0.5	0.2
Birth weight	0.2	0.3	0.5	-0.3	-0.7	0.6
Mean time to correctly identify matches	0.2	0.4	1.0	-1.0	0.4	-0.2
Handedness (chirality/laterality): Left-handed	0.2	0.3	0.8	0.0	-0.2	-0.9
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.2	0.2	0.3	0.4	-0.6	-0.3
Miserableness	0.2	0.4	1.0	-0.0	-1.0	-0.4
Eye problems/disorders: Glaucoma	0.2	0.3	0.5	-0.6	-0.7	0.0
Supplements: Fish oil (including cod liver oil)	0.2	0.3	0.7	0.2	0.2	0.8
Ever smoked	0.2	0.3	0.5	0.7	-0.7	0.3
Commuting to job workplace: Cycle	0.2	0.2	0.6	-0.1	-0.3	-0.8
Alcohol drinker status: Previous	0.2	0.3	0.4	0.6	0.6	-0.1
Pack years of smoking	0.2	0.3	0.7	-0.8	0.1	-0.5
Intelligence (Savage-Jansen 2018)	0.1	0.3	0.5	-0.6	-0.1	-0.7
Schizophrenia (2018)	0.1	0.2	0.6	0.0	-0.8	-0.2
Alzheimer’s Disease (including proxy)	0.1	0.1	0.2	-0.3	0.0	0.4
Systolic Blood Pressure	0.1	0.6	1.0	0.4	1.0	0.8
Lung FVC	0.1	0.5	1.1	1.0	0.2	0.5
Tanning	0.1	1.0	2.4	0.0	1.5	0.8
Diabetes (father)	0.1	0.1	0.1	0.1	0.4	0.3
Medication: Levothyroxine sodium	0.1	0.2	0.2	0.2	-0.5	-0.5
Forced vital capacity (FVC)	0.1	0.2	0.3	-0.5	-0.5	0.3
Forced expiratory volume in 1-second (FEV1)	0.1	0.4	0.6	0.4	-0.5	0.8
Asthma	0.1	0.1	0.2	-0.3	0.5	-0.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.2	0.5	-0.1	-0.7	-0.1
Forced vital capacity (FVC), Best measure	0.1	0.2	0.4	-0.6	-0.6	-0.1
Comparative body size at age 10	0.1	0.3	0.6	-0.1	-0.8	-0.5
Neck or shoulder pain in last month	0.1	0.1	0.2	-0.0	-0.5	-0.3
Pulse rate, automated reading	0.1	0.3	0.4	-0.7	0.5	-0.4
Asthma (self-reported)	0.1	0.2	0.4	-0.3	0.6	-0.0
Medication: Gliclazide	0.1	0.2	0.4	-0.6	-0.1	0.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.1	0.2	0.6	0.8	-0.0	-0.0
Medication: Bendroflumethiazide	0.1	0.2	0.3	0.3	-0.6	-0.5
Risk taking	0.1	0.2	0.5	0.7	0.3	0.0
Diastolic blood pressure, automated reading	0.1	0.4	1.1	0.2	0.2	1.1
Pain experienced in last month	0.1	0.2	0.7	-0.8	0.1	-0.2
Deep venous thrombosis (DVT) (self-reported)	0.1	0.1	0.2	-0.2	0.5	0.3
Verbal and Numeric Reasoning (VNR)	0.0	0.1	0.1	0.3	0.3	0.1
Heel T-Score	0.0	0.3	0.7	-0.0	0.5	0.8
Respiratory disease	0.0	0.1	0.1	0.4	0.3	-0.1
Hair Pigment	0.0	0.5	1.2	-1.1	-0.4	-0.5
Stomach or abdominal pain in last month	0.0	0.0	0.1	0.2	0.1	0.3
Number of live births	0.0	0.1	0.1	-0.2	-0.2	0.4
Seen a psychiatrist for nerves, anxiety, tension or depression	0.0	0.1	0.1	0.3	-0.0	0.3
Medication: Omeprazole	0.0	0.0	0.0	-0.2	0.0	0.2
Fractured/broken bones in last 5 years	0.0	0.0	0.0	-0.1	-0.1	0.1

Hub : Genes

PCDHGA3

Models

Trait associations