TWAS hub - BCAM

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Pancreas	0.286	0.090	0.0046	0.006	NA	-0.007	NA	0.002	0.17	NA	0.820	NA	0.26
2	GTEx	Stomach	0.331	0.108	0.0035	0.002	NA	0.011	NA	0.007	0.25	NA	0.096	NA	0.13

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
LDL Cholesterol	54.2	85.8	171.6	0.3	-13.1
Alzheimer’s Disease (including proxy)	26.1	37.9	48.9	-5.2	-7.0
High cholesterol (Self-reported)	22.4	39.7	77.1	1.5	-8.8
Alzheimer’s Disease (in mother)	19.1	22.4	35.2	-3.1	-5.9
Medication: Simvastatin	11.4	16.7	30.8	1.6	-5.5
Medication: Cholesterol lowering	11.2	17.5	34.7	0.5	-5.9
Cholesterol lowering medication	10.0	14.8	25.8	1.9	-5.1
Cardiovascular Disease	7.6	25.0	45.5	2.1	-6.7
Chronic bronchitis/emphysema (mother)	6.8	8.0	15.6	0.6	4.0
Medication: Atorvastatin	6.7	8.3	16.6	0.1	-4.1
Alzheimer’s Disease (in father)	4.6	5.0	5.9	-2.4	-2.0
Medication for cholesterol, blood pressure or diabetes	4.5	7.4	14.4	-0.6	3.8
Ulcerative Colitis	4.4	6.4	12.1	0.8	-3.5
Ulcerative Colitis (UC)	4.0	7.5	10.4	2.1	-3.2
Triglycerides	4.0	6.6	11.2	-3.3	1.4
Coronary Artery Disease (CAD)	3.7	4.4	8.8	-0.2	-3.0
Exposure to tobacco smoke at home	3.5	3.9	5.9	2.4	1.4
Medication: Co-codamol	3.4	4.0	4.8	1.8	2.2
Hayfever/allergic rhinitis (self-reported)	3.4	4.5	7.3	1.3	-2.7
Seen a psychiatrist for nerves, anxiety, tension or depression	3.1	4.0	7.8	2.8	-0.4
Mouth/teeth dental problems: Dentures	3.0	5.0	8.9	3.0	-1.0
Rheumatoid Arthritis	2.8	3.9	7.6	0.5	-2.8
Current tobacco smoking	2.7	4.4	6.2	2.5	1.6
Fluid intelligence score	2.7	5.7	11.1	-3.3	-0.5
Allergy	2.6	6.0	8.3	1.9	2.9
Number of self-reported non-cancer illnesses	2.6	4.6	6.2	1.7	-2.5
Leg fat percentage (left)	2.6	9.3	15.8	1.7	4.0
Heart disease (mother)	2.5	3.1	4.2	2.0	-1.4
Smoking status: Current	2.5	3.9	6.8	2.6	1.0
Frequency of tiredness / lethargy in last 2 weeks	2.4	3.9	7.8	-0.1	2.8
HDL Cholesterol	2.3	3.9	6.3	1.2	2.5
Body fat percentage	2.3	9.2	17.5	0.9	4.2
Leg fat percentage (right)	2.3	8.2	13.8	1.6	3.7
Leg pain on walking	2.3	2.9	3.8	2.0	1.4
Pulse rate, automated reading	2.2	7.1	12.9	-1.2	3.6
Pain type(s) experienced in last month: Hip pain	2.2	2.8	4.3	2.1	1.1
Number of treatments/medications taken	2.1	3.7	6.5	0.9	-2.5
Medication: Omeprazole	2.1	2.6	3.3	1.3	-1.8
Mean time to correctly identify matches	2.1	4.1	7.6	2.7	0.8
Leg fat mass (left)	2.1	8.1	14.4	1.4	3.8
Ever had hysterectomy (womb removed)	2.0	2.2	3.3	1.8	-1.1
Pulse rate	2.0	3.3	6.3	-0.6	2.5
Leg fat mass (right)	2.0	7.7	13.6	1.4	3.7
Commuting to job workplace: Car/motor vehicle	2.0	2.3	4.3	-0.6	-2.1
Prostate Cancer	1.9	2.7	5.1	0.5	2.2
Trunk fat percentage	1.9	7.6	15.1	0.3	3.9
Pulse wave Arterial Stiffness index	1.9	2.2	4.1	-0.6	2.0
Medication for cholesterol	1.9	2.9	5.3	-0.7	2.3
Breast cancer (self-reported)	1.9	2.2	4.1	2.0	-0.6
Irritability	1.9	3.1	5.8	2.4	0.7
Mean Putamen Volume	1.8	2.0	3.0	1.7	-1.1
Eye problems/disorders: Diabetes related eye disease	1.8	2.0	3.7	0.6	1.9
Heart attack	1.8	2.3	4.6	-0.1	-2.1
Whole body fat mass	1.8	7.6	14.5	0.8	3.8
Heart attack/myocardial infarction (self-reported)	1.8	2.3	4.5	-0.3	-2.1
Blood Eosinophil Count	1.7	13.1	18.1	2.9	-4.2
Hearing difficulty/problems: Yes	1.7	2.6	3.4	1.8	1.4
Supplements: Zinc	1.7	1.9	3.5	0.5	1.9
Medication: Atenolol	1.7	2.1	4.1	-0.1	-2.0
Trunk fat mass	1.7	7.4	14.6	0.3	3.8
Waist circumference	1.7	6.1	11.4	0.9	3.4
Diabetes (self-reported)	1.7	2.7	4.8	2.2	0.7
Pulse wave peak to peak time	1.7	2.0	3.7	0.6	-1.9
Systolic blood pressure, automated reading	1.6	4.6	8.2	2.9	-1.0
Hair/balding pattern: Pattern 2	1.6	2.0	3.3	1.8	0.8
Arm fat percentage (right)	1.6	6.2	12.0	0.5	3.5
Illnesses of father: Heart disease	1.6	2.2	4.3	-0.2	-2.1
Handedness (chirality/laterality): Left-handed	1.6	1.9	3.0	-0.9	-1.7
Commuting to job workplace: Public transport	1.6	1.9	3.8	-0.1	1.9
Illnesses of siblings: Diabetes	1.5	1.9	3.8	1.9	0.0
Arm fat percentage (left)	1.5	6.2	12.1	0.5	3.5
Medication: Aspirin	1.5	1.9	2.9	1.0	-1.7
Medication: Lisinopril	1.5	2.0	2.7	1.6	-1.1
Irritable Bowel Disease (IBD)	1.4	3.4	4.3	1.6	-2.1
Verbal and Numeric Reasoning (VNR)	1.4	3.4	6.7	-2.6	0.4
Allergy or Eczema	1.4	3.6	5.5	-1.3	-2.4
Angina	1.4	1.8	2.8	0.9	-1.7
Maternal smoking around birth	1.4	2.1	4.0	2.0	0.4
Hip circumference	1.4	6.1	11.2	1.0	3.4
Alcohol intake versus 10 years previously	1.4	2.1	3.4	-0.8	-1.8
Prospective memory result	1.4	1.7	2.8	1.7	-0.8
Arm fat mass (right)	1.4	5.9	11.4	0.6	3.4
Medication: Blood pressure	1.4	2.4	4.7	0.4	-2.2
Qualifications: nursing, teaching	1.4	2.2	3.3	-1.0	1.8
Arm fat mass (left)	1.4	5.7	11.4	0.1	3.4
Supplements: Fish oil (including cod liver oil)	1.4	1.8	3.4	1.9	-0.4
Vascular/heart problems diagnosed by doctor	1.4	3.8	4.3	-2.1	1.8
Ovarian Cancer	1.3	1.7	3.5	0.1	1.9
Diabetes (father)	1.3	1.6	1.8	-1.2	1.4
Hayfever, allergic rhinitis or eczema	1.3	2.9	4.7	-1.1	-2.2
Gout (self-reported)	1.3	1.8	2.8	1.7	-0.9
Angina (self-reported)	1.3	1.7	2.1	1.2	-1.4
Number of full sisters	1.3	1.6	2.0	1.0	1.4
Commuting to job workplace: Cycle	1.3	1.6	1.7	1.3	1.2
Blood White Count	1.2	8.6	14.0	3.7	-1.8
Systolic Blood Pressure	1.2	5.8	7.8	2.0	-2.8
Average weekly spirits intake	1.2	1.5	1.8	-1.1	1.3
Frequency of depressed mood in last 2 weeks	1.2	1.7	3.4	0.2	1.8
Medication: Metformin	1.2	1.7	3.3	1.8	0.4
Frequency of unenthusiasm / disinterest in last 2 weeks	1.2	1.6	2.3	1.5	0.9
Medication: Ramipril	1.2	1.6	2.5	0.8	-1.6
Headache pain in last month	1.2	2.1	4.0	-2.0	-0.5
Medication: Aspirin	1.2	1.6	2.9	0.6	-1.7
Forced expiratory volume in 1-second (FEV1), predicted	1.2	2.5	3.0	-1.7	1.4
Eye problems/disorders: Cataract	1.2	1.4	2.3	-0.8	-1.5
Medication: Omeprazole (e.g. Zanprol)	1.2	1.5	1.9	1.1	-1.4
Body mass index (BMI)	1.1	4.7	8.8	0.8	3.0
Weight	1.1	5.3	10.2	0.7	3.2
Length of working week for main job	1.1	1.2	2.5	-0.1	1.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.1	1.3	1.8	-0.9	1.4
Had major operations	1.1	1.3	2.5	0.4	1.6
Ever had bowel cancer screening	1.1	1.3	2.3	1.5	0.5
Diabetes diagnosed by doctor	1.1	1.8	3.2	1.8	0.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.1	1.3	1.5	1.2	-1.0
Miserableness	1.1	1.9	2.5	1.2	1.6
Pack years of smoking	1.1	1.6	3.2	1.8	-0.2
Intelligence (Savage-Jansen 2018)	1.0	3.1	6.1	-2.5	-0.4
Major Depression (MDD)	1.0	1.3	1.9	1.4	0.8
Hypothyroidism (self reported)	1.0	2.2	2.5	1.4	1.6
Respiratory disease	1.0	2.2	4.3	-0.3	-2.1
Other serious medical condition/disability diagnosed by doctor	1.0	1.3	1.3	1.1	-1.2
Had other major operations	1.0	1.2	2.3	1.5	-0.4
Mouth/teeth dental problems	1.0	1.5	2.8	-1.7	0.4
Back pain experienced in last month	1.0	1.5	2.9	0.3	1.7
Ever taken oral contraceptive pill	1.0	1.2	2.1	-1.5	-0.4
Heart disease (siblings)	1.0	1.2	2.4	0.3	-1.5
Birth weight of first child	0.9	1.7	2.1	-1.4	-1.1
Pulse wave reflection index	0.9	1.1	1.8	-1.3	-0.7
Blood clot in the leg (DVT)	0.9	1.2	2.3	-1.5	-0.2
High blood pressure (siblings)	0.9	1.3	2.3	0.6	-1.5
Hypertension (Self-reported)	0.9	2.4	3.4	1.2	-1.8
Deep venous thrombosis (DVT) (self-reported)	0.9	1.2	1.7	-1.3	-0.8
Bipolar Disorder (2018)	0.8	1.2	2.1	1.4	0.6
Type 2 Diabetes (T2D) (2018)	0.8	1.6	3.1	1.8	0.2
Fed-up feelings	0.8	1.4	2.6	-0.4	1.6
High blood pressure	0.8	2.2	2.5	1.4	-1.6
Illnesses of mother	0.8	1.0	2.0	-1.4	0.2
Knee pain experienced in last month	0.8	1.2	1.5	1.2	0.9
Long-standing illness, disability or infirmity	0.8	1.2	2.3	1.5	0.0
Ever had stillbirth, spontaneous miscarriage or termination	0.8	0.8	1.4	0.5	-1.2
Pain experienced in last month	0.8	1.4	2.7	0.2	-1.6
BMI	0.7	3.9	6.5	1.1	2.5
Vitamin and mineral supplements	0.7	0.9	1.2	-1.1	0.8
Pack years adult smoking proportion	0.7	1.0	2.0	1.4	-0.1
Average weekly fortified wine intake	0.7	0.9	1.5	0.5	-1.2
Pain all over the body in last month	0.7	0.8	1.1	1.0	0.7
Illnesses of siblings	0.7	0.9	1.1	-0.9	1.0
Time employed in main current job	0.7	0.8	1.1	-0.6	-1.1
Hair/balding pattern: Pattern 4	0.7	1.8	3.5	0.3	-1.9
Loud music exposure frequency	0.7	0.7	1.0	-0.7	1.0
Birth weight	0.7	1.5	2.2	-1.5	-0.9
Exposure to tobacco smoke outside home	0.7	0.9	0.9	0.9	-1.0
Neck or shoulder pain in last month	0.7	1.0	1.3	-1.1	0.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.7	0.8	1.1	1.0	0.7
Number of operations (self-reported)	0.7	1.0	1.3	0.9	1.1
Age at First Birth	0.6	0.9	1.4	-0.6	1.2
Body Mass Index (BMI) (2010)	0.6	0.8	1.0	1.0	0.8
Relative age of first facial hair	0.6	1.3	2.3	-0.5	-1.5
Hearing difficulty/problems with background noise	0.6	1.0	1.9	0.2	1.4
Noisy workplace	0.6	0.8	1.5	0.3	1.2
Qualifications: O levels/GCSEs or equivalent	0.6	1.0	1.9	-0.3	1.4
Mouth/teeth dental problems: Bleeding gums	0.6	0.7	1.3	-0.3	1.2
Hypothyroidism/myxoedema (self-reported)	0.6	1.3	2.0	0.7	1.4
Health satisfaction	0.6	0.8	1.6	0.2	1.2
Qualifications: College or University degree	0.6	1.8	2.6	-1.0	-1.6
Emphysema/chronic bronchitis	0.6	0.6	1.0	-0.5	-1.0
Overall health rating	0.6	1.3	1.6	1.1	1.2
Loneliness, isolation	0.6	0.8	1.6	0.1	1.3
Mineral and other dietary supplements	0.6	0.8	0.9	-0.9	-0.9
Osteoarthritis (self-reported)	0.6	0.8	1.4	0.5	1.2
Average weekly champagne plus white wine intake	0.6	0.8	1.3	1.1	0.5
Medication: Blood pressure	0.6	1.1	1.4	1.2	-0.9
Reaction Time	0.5	0.9	1.8	1.4	-0.1
Lupus	0.5	0.7	0.8	-0.8	-0.9
Smoking Status	0.5	1.3	2.5	1.6	-0.3
Sensitivity / hurt feelings	0.5	0.8	1.2	0.6	1.1
Diabetes (mother)	0.5	0.6	1.3	1.1	0.2
Townsend deprivation index at recruitment	0.5	0.7	1.4	-0.1	1.2
Taking other prescription medications	0.5	0.7	1.3	0.4	-1.1
Heel bone mineral density (BMD) T-score, automated (left)	0.5	1.1	2.0	0.4	-1.4
Qualifications: CSEs or equivalent	0.5	0.6	1.0	-1.0	0.5
Multivitamins +/- minerals	0.5	0.6	1.0	1.0	-0.5
High blood pressure (mother)	0.5	0.6	1.0	1.0	0.6
Lung cancer (father)	0.5	0.6	0.9	-1.0	0.5
Breastfed as a baby	0.5	0.6	1.0	-1.0	-0.5
Medication: Allopurinol	0.5	0.7	1.1	0.6	-1.0
Suffer from ‘nerves’	0.5	0.8	1.5	-1.2	-0.4
Asthma (self-reported)	0.5	0.9	1.8	-0.2	-1.3
Medication: Gliclazide	0.5	0.6	0.7	0.8	0.7
Hearing aid user	0.5	0.6	1.1	-0.3	-1.0
Medication: Bendroflumethiazide	0.5	0.7	1.5	-1.2	0.1
Myopia	0.5	0.7	1.3	1.1	-0.2
Bipolar Disorder or Schizophrenia	0.4	1.1	1.6	0.8	1.3
HbA1C	0.4	0.4	0.9	0.0	-0.9
Neuroticism (2016)	0.4	0.6	0.8	0.9	0.7
Ever used hormone-replacement therapy (HRT)	0.4	0.5	1.0	1.0	-0.1
Severe depression (siblings)	0.4	0.5	0.9	0.2	-1.0
Relative age voice broke	0.4	0.6	1.1	-0.4	-1.0
Had menopause	0.4	0.6	0.6	0.8	-0.7
Qualifications: None of the above	0.4	0.8	1.5	1.2	-0.2
Father’s age at death	0.4	0.6	0.6	-0.8	0.8
Hair/balding pattern: Pattern 3	0.4	0.6	0.9	-0.9	0.5
Qualifications: A levels/AS levels or equivalent	0.4	1.0	1.9	-1.4	-0.2
Asthma	0.4	0.9	1.7	-0.0	-1.3
Medication: Ibuprofen (e.g. Nurofen)	0.4	0.4	0.5	-0.6	-0.7
Forced expiratory volume in 1-second (FEV1), Best measure	0.4	1.2	1.6	-1.3	-0.9
Number of children fathered	0.4	0.5	0.6	0.8	0.6
Medication: Ibuprofen	0.4	0.4	0.5	-0.7	-0.6
Medication: Seretide 50 evohaler	0.4	0.5	1.0	-1.0	0.2
Illness, injury, bereavement, stress in last 2 years	0.4	0.5	0.5	-0.7	0.7
Friendships satisfaction	0.4	0.5	0.7	-0.5	-0.8
Osteoporosis (self-reported)	0.4	0.5	0.8	-0.9	0.5
Mother’s age at death	0.4	0.4	0.8	-0.3	0.9
Risk taking	0.4	0.6	0.7	0.7	0.8
Alcohol drinker status: Previous	0.4	0.4	0.7	0.9	0.3
Schizophrenia (2018)	0.3	0.7	1.4	0.1	1.2
Medication: Levothyroxine sodium	0.3	0.5	0.8	0.5	0.9
Number of incorrect matches in round	0.3	0.5	0.7	0.5	-0.8
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.7	1.4	0.2	-1.2
Ever unenthusiastic/disinterested for a whole week	0.3	0.4	0.4	0.6	0.6
Financial difficulties in last 2 years	0.3	0.4	0.7	-0.3	0.8
Depression (self-reported)	0.3	0.3	0.7	-0.8	-0.0
Tense / ‘highly strung’	0.3	0.6	0.8	0.9	0.5
Medication: Ventolin 100micrograms inhaler	0.3	0.4	0.7	0.3	-0.9
Forced vital capacity (FVC), Best measure	0.3	1.2	2.2	-1.5	-0.5
Comparative body size at age 10	0.3	0.9	1.2	0.8	-1.1
Number of full brothers	0.3	0.3	0.6	0.3	-0.8
Worry too long after embarrassment	0.3	0.6	0.8	-0.9	-0.5
Reason for reducing amount of alcohol drunk: Health precaution	0.3	0.3	0.5	-0.7	-0.3
Migraine (self-reported)	0.3	0.3	0.6	-0.8	0.3
Age at last live birth	0.3	0.4	0.7	-0.1	0.9
Supplements: Vitamin C	0.3	0.3	0.4	0.6	0.5
Commuting to job workplace: Walk	0.3	0.3	0.4	0.7	0.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.3	0.7	1.4	-0.1	-1.2
Eye problems/disorders: Glaucoma	0.3	0.4	0.5	-0.7	-0.6
Medication: Paracetamol	0.3	0.5	0.7	-0.8	0.5
Ever had prostate specific antigen (PSA) test	0.3	0.3	0.6	0.1	0.8
Age started oral contraceptive pill	0.3	0.4	0.7	0.8	-0.2
Unable to work because of sickness or disability	0.3	0.3	0.6	-0.3	-0.8
Depression (Nagel 2018)	0.2	0.2	0.4	0.4	0.6
Worry (Nagel 2018)	0.2	0.3	0.6	0.0	-0.8
Breast Cancer	0.2	0.4	0.5	0.7	-0.6
Fasting Glucose	0.2	0.3	0.5	-0.7	-0.1
Schizophrenia (2014)	0.2	0.4	0.8	0.2	0.9
Type 2 Diabetes (T2D) (2012)	0.2	0.3	0.5	0.3	0.7
Blood Red Count	0.2	1.8	3.1	-0.7	1.8
Heel T-Score	0.2	1.5	3.0	1.7	-0.1
Neuroticism	0.2	0.4	0.8	0.9	-0.2
Hand grip strength (left)	0.2	0.4	0.5	-0.6	-0.7
Leg fat-free mass (left)	0.2	1.0	1.9	0.2	1.4
Serious illness, injury or assault to yourself	0.2	0.2	0.3	-0.4	0.5
Leg predicted mass (left)	0.2	0.9	1.8	0.2	1.4
Alcohol usually taken with meals	0.2	0.4	0.6	0.7	0.5
Nervous feelings	0.2	0.3	0.4	-0.5	-0.6
Falls in the last year	0.2	0.2	0.4	0.0	0.6
Forced expiratory volume in 1-second (FEV1)	0.2	0.7	0.9	-0.9	-0.8
Happiness	0.2	0.2	0.3	-0.6	0.2
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.3	0.7	0.0	0.8
Ever highly irritable/argumentative for 2 days	0.2	0.3	0.4	-0.3	-0.7
Glaucoma (self-reported)	0.2	0.2	0.4	-0.0	0.7
Medication: Amlodipine	0.2	0.3	0.5	0.1	-0.7
Arm fat-free mass (right)	0.2	0.8	1.6	0.1	1.2
Wheeze or whistling in the chest in last year	0.2	0.4	0.8	0.9	0.1
Age at first live birth	0.2	0.4	0.7	-0.9	0.2
Shortness of breath walking on level ground	0.2	0.3	0.5	0.2	0.7
Medication for pain relief, constipation, heartburn	0.2	0.4	0.7	0.0	0.9
Arm predicted mass (right)	0.2	0.9	1.8	0.0	1.3
Alcohol intake frequency.	0.2	0.4	0.5	-0.7	0.5
Family relationship satisfaction	0.2	0.2	0.2	0.5	-0.4
Leg fat-free mass (right)	0.2	1.2	2.4	0.2	1.5
Illnesses of father: None of the above (group 1)	0.2	0.3	0.3	0.6	0.5
Leg predicted mass (right)	0.2	1.2	2.3	0.2	1.5
Illnesses of father: High blood pressure	0.2	0.3	0.4	-0.5	0.6
Basal metabolic rate	0.2	1.3	2.6	0.2	1.6
Arm fat-free mass (left)	0.2	1.0	1.9	0.1	1.4
Diastolic blood pressure, automated reading	0.2	0.6	0.7	0.7	0.8
Supplements: Calcium	0.2	0.2	0.2	0.4	0.4
Arm predicted mass (left)	0.2	1.0	1.8	0.4	1.3
Neuroticism (Nagel 2018)	0.1	0.1	0.2	0.4	0.4
Schizophrenia vs Biploar Disorder	0.1	0.2	0.4	0.1	0.6
Crohns Disease (2017)	0.1	0.2	0.4	0.6	-0.0
Crohns Disease (2012)	0.1	0.1	0.2	-0.3	-0.4
Height	0.1	2.4	4.7	-0.0	2.2
Waist Hip Ratio (WHR)	0.1	0.2	0.5	0.1	-0.7
Lung FEV1/FVC ratio	0.1	0.5	0.8	0.9	0.4
Chronotype (morning person)	0.1	0.3	0.5	0.4	-0.7
Hair Pigment	0.1	1.7	3.2	-1.8	0.3
Tanning	0.1	1.8	2.3	1.5	-1.2
Medication for hormone replacement therapy	0.1	0.1	0.1	0.1	0.3
Hand grip strength (right)	0.1	0.4	0.4	-0.5	-0.7
Age when periods started (menarche)	0.1	0.1	0.2	-0.2	-0.4
Tinnitus: Yes, but not now, but have in the past	0.1	0.1	0.1	0.2	0.3
Stomach or abdominal pain in last month	0.1	0.1	0.2	-0.4	0.1
Diverticular disease/diverticulitis (self-reported)	0.1	0.1	0.2	0.5	0.2
Sitting height	0.1	0.5	1.0	-1.0	0.2
Chronic bronchitis/emphysema (father)	0.1	0.1	0.1	0.4	0.2
Impedance of leg (left)	0.1	0.3	0.4	-0.6	0.5
Frequency of tenseness / restlessness in last 2 weeks	0.1	0.1	0.2	0.4	-0.3
Forced vital capacity (FVC)	0.1	0.5	0.7	-0.8	-0.5
Impedance of arm (right)	0.1	0.3	0.6	-0.8	-0.1
Worrier / anxious feelings	0.1	0.2	0.4	-0.6	-0.0
Number of live births	0.1	0.2	0.2	-0.5	-0.4
Serious illness, injury or assault of a close relative in last 2 years	0.1	0.1	0.1	0.3	-0.2
Impedance of arm (left)	0.1	0.4	0.7	-0.8	0.2
Standing height	0.1	0.6	0.8	-0.5	0.9
Peak expiratory flow (PEF)	0.1	0.2	0.3	-0.5	-0.3
Eye problems/disorders: None of the above	0.1	0.1	0.2	-0.4	0.1
Comparative height size at age 10	0.1	0.4	0.7	0.3	0.9
Chest pain or discomfort	0.1	0.2	0.3	-0.5	0.3
Qualifications: NVQ or HND or HNC or equivalent	0.1	0.1	0.2	0.4	0.2
Smoking status: Previous	0.1	0.2	0.4	-0.6	0.3
Whole body fat-free mass	0.1	0.6	1.1	0.1	1.1
Average weekly red wine intake	0.1	0.2	0.2	-0.5	-0.3
Mood swings	0.1	0.1	0.2	0.2	0.4
Whole body water mass	0.1	0.6	1.1	0.2	1.0
Wears glasses or contact lenses	0.1	0.1	0.3	0.1	0.5
Financial situation satisfaction	0.1	0.1	0.1	0.3	0.2
Alcohol drinker status: Never	0.1	0.1	0.1	0.4	0.2
Fractured/broken bones in last 5 years	0.1	0.2	0.3	-0.6	0.2
Ever depressed for a whole week	0.1	0.1	0.1	-0.4	0.0
Basal cell carcinoma (self-reported)	0.1	0.1	0.1	0.3	0.3
Impedance of whole body	0.1	0.5	0.7	-0.8	0.5
Depressed Affect (Nagel 2018)	0.0	0.1	0.1	0.0	0.4
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0
Primary Biliary Cirrhosis	0.0	0.0	0.1	-0.1	0.2
Blood Platelet Count	0.0	0.1	0.1	-0.3	0.2
Lung FVC	0.0	0.2	0.3	-0.6	0.0
Impedance of leg (right)	0.0	0.2	0.4	-0.7	-0.2
Bilateral oophorectomy (both ovaries removed)	0.0	0.1	0.1	0.3	-0.1
Supplements: Glucosamine	0.0	0.0	0.0	0.0	0.1
Past tobacco smoking	0.0	0.0	0.0	0.0	-0.0
Neuroticism score	0.0	0.0	0.1	0.1	0.3
Trunk fat-free mass	0.0	0.1	0.2	0.2	0.5
Medication: Lansoprazole	0.0	0.0	0.1	-0.2	0.2
Trunk predicted mass	0.0	0.2	0.3	0.2	0.5
Medication: Paracetamol	0.0	0.1	0.1	-0.3	0.0
Mouth/teeth dental problems: Loose teeth	0.0	0.1	0.1	-0.0	0.3
Mouth/teeth dental problems: Mouth ulcers	0.0	0.1	0.1	-0.3	-0.1
Guilty feelings	0.0	0.0	0.0	-0.1	0.1
Tinnitus: Yes, now most or all of the time	0.0	0.0	0.0	-0.2	-0.1
Ever smoked	0.0	0.0	0.0	-0.0	0.0
Average weekly beer plus cider intake	0.0	0.0	0.1	0.3	0.0

Hub : Genes

BCAM

Models

Trait associations