Hub : Genes

PVRL2

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.1000	0.0320	1.6e-03	0.029	0.029	0.021	NA	0.031	1.5e-04	1.6e-04	1.1e-03	NA	9.3e-05
2	GTEx	Esophagus Mucosa	0.1480	0.0520	4.8e-03	0.008	NA	0.020	NA	0.018	8.8e-02	NA	1.7e-02	NA	2.2e-02
3	GTEx	Liver	0.2910	0.0930	3.1e-03	0.239	NA	0.144	NA	0.212	2.6e-07	NA	8.3e-05	NA	1.4e-06
4	GTEx	Whole Blood	0.5970	0.0400	0.0e+00	0.584	NA	0.611	NA	0.613	5.7e-66	NA	6.5e-71	NA	3.6e-71
5	NTR	Blood	0.2430	0.0256	0.0e+00	0.248	0.219	0.275	0.272	0.282	3.1e-79	9.3e-69	4.2e-89	9.1e-88	8.5e-92
6	YFS	Blood	0.4033	0.0348	0.0e+00	0.334	0.307	0.362	0.363	0.365	1.6e-113	1.3e-102	2.1e-125	1.1e-125	9.5e-127
7	TCGA	Brain Lower Grade Glioma	0.0445	0.0220	2.4e-03	0.013	0.021	0.003	NA	0.003	1.0e-02	1.6e-03	1.2e-01	NA	1.5e-01
8	TCGA	Liver Hepatocellular Carcinoma	0.0890	0.0410	2.3e-03	0.009	0.044	0.009	NA	0.009	1.2e-01	4.0e-03	1.2e-01	NA	1.1e-01
9	TCGA	Prostate Adenocarcinoma	0.1010	0.0404	6.6e-06	0.043	0.044	0.039	NA	0.043	2.3e-05	1.8e-05	5.3e-05	NA	2.6e-05
10	TCGA	Thyroid Carcinoma	0.0860	0.0360	2.2e-04	0.049	0.031	0.021	NA	0.026	1.4e-05	4.6e-04	3.3e-03	NA	1.3e-03

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10
Bipolar Disorder (2018)	0.9	1.4	4.1	1.4	0.5	0.8	0.6	1.5	0.8	1.2	2.0	-1.3	-0.7
Bipolar Disorder or Schizophrenia	0.4	1.0	5.0	1.2	2.2	0.7	-0.2	0.3	-0.1	0.8	1.0	-0.6	-0.8
Depressed Affect (Nagel 2018)	0.9	1.9	4.8	-0.8	0.5	-2.2	-0.6	-1.5	-0.8	-1.3	-1.8	1.5	1.7
Depression (Nagel 2018)	0.4	0.6	4.4	0.3	2.1	-0.2	0.4	0.1	0.3	-0.9	-0.3	0.8	0.2
Intelligence (Savage-Jansen 2018)	1.1	3.5	8.5	-2.9	-1.3	-2.1	-1.4	-2.2	-1.6	0.4	-2.7	-1.5	1.0
Neuroticism (Nagel 2018)	0.8	2.0	5.1	-0.6	1.0	-2.2	0.5	-0.4	0.3	-1.8	-2.0	1.1	2.0
Schizophrenia (2018)	0.4	0.9	6.2	0.4	2.5	0.3	-0.8	-0.8	-0.8	-0.0	-0.3	0.4	-0.4
Schizophrenia vs Biploar Disorder	0.1	0.2	1.6	-0.2	-0.0	1.3	0.4	0.2	0.4	0.0	0.0	0.0	0.0
Worry (Nagel 2018)	0.4	0.9	2.9	-1.4	-0.1	-1.0	0.4	-0.2	0.3	-1.1	-1.7	0.1	1.4
Alzheimer’s Disease (in mother)	17.6	20.6	66.6	-7.5	1.8	5.5	-0.1	-0.1	-0.0	4.7	-3.1	-4.1	-8.2
Alzheimer’s Disease (in father)	10.4	11.3	41.0	-4.4	0.9	3.6	-2.0	-1.7	-1.9	3.7	-2.3	-3.0	-6.4
Alzheimer’s Disease (including proxy)	42.5	61.7	182.2	-13.5	1.9	9.6	-1.7	-2.0	-1.7	8.3	-5.7	-7.8	-12.9
Crohns Disease (2017)	0.4	0.9	2.7	-0.2	1.0	-0.4	1.6	1.2	1.6	-0.8	-0.2	0.8	0.3
Irritable Bowel Disease (IBD)	1.2	3.0	7.9	-0.4	1.5	-1.0	2.8	2.2	2.8	-1.6	-0.9	1.5	-0.1
Ulcerative Colitis (UC)	1.8	3.4	9.3	0.3	1.6	-0.5	3.0	2.7	3.0	-1.5	-0.5	1.6	-0.4
Major Depression (MDD)	0.4	0.4	1.1	0.2	-1.0	0.5	-0.7	-0.3	-0.6	-0.9	-0.5	1.0	0.5
Reaction Time	1.5	2.9	10.2	1.4	3.2	-0.7	1.2	2.3	1.6	-1.1	0.4	1.6	-1.6
Verbal and Numeric Reasoning (VNR)	2.0	4.8	13.0	-3.6	-1.6	-1.1	-1.9	-2.9	-2.2	0.9	-2.5	-2.3	1.4
Breast Cancer	1.2	2.8	10.1	-1.5	0.7	-3.2	-0.3	-1.3	-0.5	-1.8	-2.2	2.3	0.0
Ovarian Cancer	0.4	0.5	3.6	-0.3	-1.9	-0.0	0.1	-0.6	-0.1	-0.4	-0.4	0.5	0.8
Prostate Cancer	2.5	3.5	6.2	2.0	1.8	0.6	0.6	2.0	1.0	2.1	2.5	-2.2	-2.5
Age at First Birth	1.2	1.7	8.7	0.4	0.0	1.6	0.2	0.3	0.2	2.1	1.0	-3.0	-0.3
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	1.0	1.3	3.9	2.0	0.6	-0.9	-1.2	-0.3	-1.0	-0.9	0.2	2.0	-1.0
Coronary Artery Disease (CAD)	0.4	0.4	3.8	-0.0	1.9	-0.3	0.2	0.4	0.3	0.0	0.0	0.0	0.0
Crohns Disease (2012)	0.3	0.5	1.4	-1.0	0.2	-0.7	1.0	0.3	0.9	-0.0	-1.2	-0.6	0.5
Mean Putamen Volume	2.3	2.6	7.5	2.4	1.4	0.1	1.8	2.7	2.1	-0.7	1.1	0.4	-1.2
Fasting Glucose	0.3	0.4	1.5	-0.3	-1.2	-0.7	0.3	-0.3	0.2	-0.4	-0.1	0.5	0.9
HbA1C	1.5	1.7	4.7	-0.1	0.5	-1.2	1.3	0.7	1.2	-2.2	-1.9	1.9	0.4
HDL Cholesterol	1.9	3.2	17.6	0.1	-3.2	-0.9	0.5	-0.7	0.1	-1.4	-0.2	-0.2	4.2
LDL Cholesterol	47.7	75.4	380.2	0.4	16.2	2.6	3.5	7.9	4.8	1.7	1.8	1.0	-19.5
Lupus	1.5	2.3	7.6	-2.8	-0.6	-0.6	1.4	-0.6	1.0	-1.6	-1.4	0.1	2.6
Neuroticism (2016)	0.9	1.3	3.1	-1.3	0.4	-0.9	1.0	-0.1	0.8	-1.6	-0.7	1.5	1.7
Primary Biliary Cirrhosis	1.0	1.4	5.7	-1.4	0.2	-1.8	0.6	-0.7	0.3	-1.2	-2.4	0.3	0.8
Rheumatoid Arthritis	0.6	0.8	1.9	0.9	-0.1	1.3	1.2	0.8	1.2	-0.3	0.0	-0.0	1.4
Schizophrenia (2014)	0.3	0.6	3.8	1.0	1.9	0.6	-0.2	0.3	-0.1	0.6	0.4	-0.6	-0.6
Triglycerides	6.6	10.8	30.8	0.3	-1.1	-0.6	-4.8	-2.6	-4.5	5.5	2.3	-2.1	-4.0
Type 2 Diabetes (T2D) (2012)	0.2	0.2	0.8	0.9	0.3	-0.9	-0.3	0.1	-0.2	0.0	0.0	0.0	0.0
Ulcerative Colitis	0.4	0.5	1.4	-0.4	0.4	-0.5	1.1	1.2	1.1	-0.4	0.0	0.7	-0.5
Blood Eosinophil Count	2.7	21.0	52.9	1.1	5.6	0.1	7.0	7.0	7.3	-3.6	-0.8	2.7	-2.5
Blood Platelet Count	0.2	2.5	14.7	0.2	-1.3	-1.2	0.3	-0.8	0.0	-1.0	-1.9	-1.3	3.8
Blood Red Count	0.4	4.3	19.4	-0.1	-3.2	1.3	-1.2	-2.4	-1.6	-0.2	1.1	0.8	4.4
Blood White Count	1.7	12.4	29.2	-1.1	-1.1	1.8	5.4	2.5	5.0	-4.7	-1.2	2.4	5.4
Heel T-Score	0.2	1.7	7.0	2.6	0.9	1.5	0.3	1.4	0.5	0.5	2.0	0.5	-0.4
BMI	0.8	4.6	14.1	1.7	-0.8	-2.7	-0.1	-0.4	-0.2	-3.4	-0.0	3.8	2.9
Height	0.2	4.1	8.9	2.6	0.7	1.1	-2.4	-1.2	-2.3	3.0	2.8	-1.2	-1.3
Waist Hip Ratio (WHR)	0.2	0.7	3.0	1.7	1.3	-0.8	0.6	0.7	0.6	-0.3	0.5	-0.2	0.4
Systolic Blood Pressure	0.8	4.2	10.3	1.1	3.2	1.8	1.9	2.6	2.1	-0.7	1.5	1.0	-3.0
Smoking Status	0.5	1.2	3.1	1.3	1.1	-0.4	1.7	1.6	1.8	-0.5	0.2	0.4	0.0
Allergy or Eczema	2.0	5.4	23.8	1.3	4.9	-2.3	-1.0	0.1	-0.7	0.0	-1.4	0.9	-4.4
Cardiovascular Disease	3.6	11.9	51.3	-0.5	5.4	-0.0	2.7	4.0	3.2	-1.0	-0.2	1.8	-7.2
Hypothyroidism (self reported)	0.1	0.3	0.8	0.0	-0.6	-0.9	0.9	0.0	0.7	-0.0	-0.4	0.5	0.1
Respiratory disease	3.2	7.0	25.6	0.2	2.2	-3.2	-0.3	-0.4	-0.3	-4.3	-3.2	5.1	0.9
Type 2 Diabetes (T2D) (2018)	3.3	6.1	21.3	-1.2	0.9	-2.6	1.1	-0.2	0.9	-4.6	-2.2	4.2	2.4
Lung FEV1/FVC ratio	0.4	2.2	5.6	0.0	2.1	-2.4	0.5	1.1	0.6	-1.5	-0.5	2.0	-1.9
Lung FVC	1.4	7.0	19.2	3.6	2.9	1.7	-1.2	1.3	-0.7	2.9	3.5	-1.1	-4.4
Neuroticism	0.8	1.8	5.5	0.0	1.2	-1.3	0.6	0.2	0.5	-2.3	-1.1	2.2	1.8
Chronotype (morning person)	0.8	1.8	6.8	0.2	1.0	2.0	0.2	1.3	0.4	0.8	2.0	-0.4	-2.6
Hair Pigment	0.1	2.3	7.2	-0.4	1.4	-2.0	-1.9	-1.1	-1.8	0.5	-0.4	0.9	-2.7
Tanning	0.2	2.7	4.9	-0.1	2.1	-0.7	2.1	1.9	2.2	-1.9	-0.2	2.1	-0.7
Hand grip strength (left)	1.8	4.8	16.6	3.2	2.3	-0.0	0.1	1.9	0.5	2.1	2.5	-0.9	-4.1
Number of treatments/medications taken	1.2	2.2	8.1	0.1	2.0	-0.7	0.7	1.6	0.9	-1.4	-0.9	1.8	-2.9
Average weekly spirits intake	0.8	1.0	3.8	0.3	-0.2	-2.0	0.2	-0.1	0.1	-1.3	-0.8	1.9	0.5
Sensitivity / hurt feelings	0.5	0.9	3.4	-0.1	0.1	-0.8	-0.4	-1.1	-0.6	-1.0	-0.8	1.2	1.9
Frequency of depressed mood in last 2 weeks	0.6	0.8	3.0	1.6	1.7	0.4	-0.6	0.3	-0.4	-0.1	0.7	0.7	-1.0
Hearing difficulty/problems: Yes	0.5	0.8	1.7	-0.4	0.1	0.6	-1.3	-1.0	-1.2	0.8	1.0	-1.0	-0.0
Relative age of first facial hair	0.9	1.9	4.7	2.1	2.2	-0.3	0.1	1.0	0.3	1.4	1.2	-1.0	-2.1
Other serious medical condition/disability diagnosed by doctor	1.2	1.5	5.0	-1.3	0.6	-1.1	0.6	0.4	0.6	-2.2	-1.4	2.0	0.5
Ever used hormone-replacement therapy (HRT)	0.2	0.2	0.7	0.4	0.8	-0.1	0.0	-0.5	-0.1	-0.8	0.4	0.8	0.0
Ever had hysterectomy (womb removed)	0.9	1.0	3.9	-0.1	1.7	0.4	1.0	0.5	0.9	-2.0	-0.3	1.0	0.4
Systolic blood pressure, automated reading	0.6	1.7	4.2	1.2	1.8	0.8	1.4	1.4	1.4	-1.0	2.0	1.1	-0.5
Eye problems/disorders: Diabetes related eye disease	1.5	1.7	4.7	0.1	1.2	-2.2	1.3	1.0	1.3	-1.8	-0.7	1.6	-0.6
Angina	2.2	2.9	6.3	-1.4	2.5	-0.9	1.8	1.2	1.8	-1.8	-1.2	2.4	-1.2
Medication for hormone replacement therapy	0.5	0.5	2.7	0.8	0.9	-0.7	-0.3	0.4	-0.2	0.7	0.1	-0.4	-1.6
Vitamin and mineral supplements	1.3	1.8	8.6	-1.1	-2.2	1.2	0.5	-0.9	0.1	0.2	0.2	-0.8	2.9
Supplements: Zinc	0.3	0.4	0.9	0.2	-1.0	0.7	-0.5	-0.6	-0.6	0.7	0.5	-0.6	0.3
Medication: Co-codamol	0.5	0.6	2.4	-0.3	-0.8	-0.7	0.7	0.3	0.7	-0.6	-1.1	-0.1	1.5
Medication: Metformin	5.0	7.0	22.8	-0.7	0.5	-2.5	2.8	1.3	2.6	-4.8	-1.5	4.3	1.9
Diabetes (father)	1.6	2.0	7.4	-0.7	-0.9	-2.7	1.0	-0.2	0.7	-1.3	-1.4	0.7	2.4
Diabetes (mother)	3.3	4.3	15.7	0.2	-0.7	-1.1	1.5	0.3	1.3	-3.4	-0.7	3.1	4.0
Severe depression (siblings)	0.4	0.5	1.2	-0.6	0.1	0.5	1.1	0.8	1.1	-0.7	0.1	0.0	0.8
Pack years adult smoking proportion	1.4	2.2	4.8	0.9	0.0	-0.9	2.1	1.7	2.1	-1.6	1.0	2.2	0.4
Impedance of leg (right)	0.5	2.5	9.2	0.6	0.2	1.7	0.3	0.8	0.3	3.0	1.6	-2.4	-1.9
Leg fat-free mass (left)	0.5	2.4	8.2	0.8	-0.8	-1.5	-0.4	-0.4	-0.4	-2.5	-0.4	2.9	2.4
Trunk fat percentage	0.9	3.8	17.9	0.6	-2.0	-1.4	-0.9	-1.5	-1.1	-2.0	-0.2	2.3	4.2
Hand grip strength (right)	2.3	6.3	19.5	3.4	1.0	1.3	-0.7	1.8	-0.2	3.2	3.4	-1.7	-4.4
Townsend deprivation index at recruitment	0.7	1.0	3.9	2.0	-0.3	0.9	0.7	1.2	0.9	-0.1	1.4	0.7	0.0
Current tobacco smoking	1.2	2.0	6.8	0.8	-1.1	0.1	1.3	0.7	1.2	-1.8	0.3	2.1	2.6
Average weekly fortified wine intake	1.3	1.6	5.5	1.6	1.6	-0.9	-0.8	0.9	-0.4	0.4	1.2	1.0	-2.3
Maternal smoking around birth	2.8	4.0	10.2	3.2	1.7	2.0	1.1	2.4	1.4	1.8	2.8	-1.2	-1.3
Fed-up feelings	1.0	1.9	4.9	-0.3	-0.8	-0.9	-1.5	-2.2	-1.7	-0.8	-0.9	1.4	1.9
Frequency of unenthusiasm / disinterest in last 2 weeks	1.4	1.9	7.3	0.2	1.0	0.3	0.7	0.0	0.6	-2.6	-0.3	2.7	1.6
Relative age voice broke	0.9	1.4	7.2	2.0	2.7	-0.3	0.0	0.7	0.2	-0.1	-0.0	0.2	-1.4
Taking other prescription medications	2.9	4.4	12.7	0.2	2.3	-2.7	-0.6	0.1	-0.4	-3.1	-2.3	3.6	-1.6
Age when periods started (menarche)	0.0	0.1	0.4	0.3	-0.2	0.1	-0.0	-0.3	-0.1	0.0	0.2	0.2	0.6
Bilateral oophorectomy (both ovaries removed)	0.6	0.7	4.2	0.3	2.0	-0.5	-0.1	0.4	0.1	-0.2	0.2	0.6	-1.3
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.5	1.7	0.7	1.3	-0.7	-0.0	0.7	0.1	0.1	-0.0	0.6	-1.1
Tinnitus: Yes, but not now, but have in the past	0.3	0.3	2.0	0.2	-1.4	0.7	-0.4	0.1	-0.3	-0.6	0.4	0.4	0.3
Qualifications: CSEs or equivalent	0.3	0.4	1.3	-0.3	0.7	0.8	-0.3	0.2	-0.2	1.1	0.4	-1.1	-0.1
Serious illness, injury or assault to yourself	0.2	0.2	0.9	0.6	0.9	0.1	-0.1	0.7	0.1	-0.0	0.8	0.1	-0.2
High blood pressure	0.5	1.5	3.1	0.5	1.3	0.0	1.7	1.6	1.8	-1.1	0.8	1.4	-0.8
Hayfever, allergic rhinitis or eczema	2.2	4.8	21.0	1.8	4.6	-1.1	-0.5	1.1	-0.2	0.3	-0.7	0.3	-4.5
Multivitamins +/- minerals	0.9	1.1	3.5	0.9	1.8	-1.4	-1.0	0.1	-0.8	-0.3	-0.5	0.4	-1.9
Stomach or abdominal pain in last month	0.6	0.8	2.4	-1.4	-0.1	-0.6	0.2	-0.1	0.2	-1.5	-1.5	0.7	0.7
Supplements: Glucosamine	0.3	0.4	1.4	-1.2	-0.7	-0.8	0.4	-0.0	0.3	-0.4	-1.0	-0.3	0.4
Diverticular disease/diverticulitis (self-reported)	0.5	0.6	1.0	-0.9	-0.6	-1.0	-0.9	-1.0	-1.0	-0.2	-0.9	-0.5	0.7
Medication: Atenolol	0.7	0.8	2.3	-1.2	-0.1	-0.8	1.0	0.3	0.9	-0.5	-0.4	1.3	-1.5
Medication: Levothyroxine sodium	0.4	0.6	2.2	-0.7	-1.5	-1.0	-0.3	-1.0	-0.5	-0.3	-1.0	0.6	0.1
Sitting height	0.1	1.0	2.1	1.1	1.0	1.2	-1.0	0.2	-0.7	1.3	1.0	-0.0	-1.4
Chronic bronchitis/emphysema (father)	1.3	1.5	3.8	0.1	-0.8	-0.5	2.0	1.3	1.9	-1.1	0.5	0.5	1.8
High blood pressure (mother)	1.1	1.5	4.6	2.1	1.0	0.8	0.9	1.6	1.1	-0.5	1.9	0.4	-0.2
Body mass index (BMI)	1.3	5.5	16.0	0.3	-1.6	-2.7	-0.4	-1.3	-0.6	-3.6	-1.0	3.7	4.0
Impedance of leg (left)	0.5	2.4	9.1	0.4	0.2	1.7	0.2	0.5	0.2	3.0	1.5	-2.5	-1.7
Leg predicted mass (left)	0.5	2.4	8.2	0.9	-0.8	-1.4	-0.3	-0.4	-0.4	-2.5	-0.3	2.9	2.5
Trunk fat mass	1.0	4.2	16.3	0.8	-1.8	-1.8	-1.0	-1.5	-1.2	-2.3	-0.2	2.9	4.0
Waist circumference	1.0	3.7	15.3	0.9	-1.5	-1.8	-0.7	-1.1	-0.8	-2.5	-0.1	2.8	3.9
Number of incorrect matches in round	0.4	0.6	2.8	0.4	1.7	0.8	-0.1	0.6	0.1	0.5	1.0	-0.3	-0.7
Past tobacco smoking	1.5	2.7	5.4	-1.1	-2.3	0.3	-1.5	-1.8	-1.6	-1.6	-0.2	2.2	2.2
Alcohol usually taken with meals	0.6	0.9	4.3	-0.3	-0.6	0.9	0.4	0.5	0.4	-2.1	-1.1	0.7	1.3
Nervous feelings	1.0	1.9	6.2	-2.3	-0.4	-1.0	-0.2	-1.3	-0.5	-0.7	-2.5	-0.0	2.1
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.4	2.2	0.2	0.1	0.0	0.1	0.3	0.2	-1.1	-0.1	1.5	0.4
Hearing difficulty/problems with background noise	0.6	0.9	2.9	-1.1	0.2	0.2	-1.7	-1.3	-1.6	-0.0	-0.5	-0.4	-0.7
Hair/balding pattern: Pattern 2	1.9	2.4	7.2	1.8	0.9	2.7	1.2	1.7	1.3	0.9	2.2	-0.4	-0.8
Had menopause	0.2	0.3	1.1	-0.6	1.1	-0.8	0.5	-0.4	0.3	-0.3	-0.2	0.3	0.2
Had other major operations	0.4	0.5	1.2	1.0	-0.4	-0.6	0.7	1.1	0.8	-0.6	0.2	0.7	-0.1
Forced vital capacity (FVC)	1.5	5.9	15.7	3.0	3.0	1.7	0.1	1.9	0.5	3.0	2.6	-1.6	-4.0
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.4	1.6	0.2	1.3	-0.7	-0.5	-0.0	-0.4	0.2	-0.4	0.3	-0.9
Ever unenthusiastic/disinterested for a whole week	0.6	0.8	2.8	-0.1	-0.5	-1.1	-0.5	-0.7	-0.5	-0.9	-0.7	1.7	1.1
Qualifications: None of the above	0.7	1.6	6.8	1.0	1.4	-0.1	0.7	0.4	0.7	-1.4	1.1	2.6	1.2
Financial difficulties in last 2 years	1.0	1.4	4.0	-0.1	-0.8	-1.1	-1.7	-2.0	-1.8	-0.5	-0.7	0.7	0.7
Mouth/teeth dental problems	2.6	4.0	10.5	1.4	2.0	-1.0	-3.2	-1.5	-2.9	1.5	0.0	-0.0	-3.0
Heart attack	0.9	1.2	2.7	-1.6	1.2	-1.2	0.4	0.6	0.5	-0.8	-0.6	1.5	-1.4
Allergy	1.8	4.2	14.9	-0.9	-3.9	2.4	0.9	-0.1	0.8	1.7	2.2	-1.9	2.7
Pain all over the body in last month	1.4	1.5	5.9	0.3	1.2	-0.0	1.3	0.8	1.3	-1.8	-0.4	2.4	0.4
Diabetes (self-reported)	3.9	6.0	19.3	-1.3	0.5	-2.1	2.5	1.1	2.3	-4.4	-1.4	3.7	2.4
Hayfever/allergic rhinitis (self-reported)	2.3	3.0	8.2	-0.3	2.9	-2.2	0.7	0.7	0.8	-2.2	-1.8	2.3	-1.2
Medication: Ramipril	1.8	2.3	4.8	-1.1	1.6	-0.6	2.2	1.9	2.2	-1.9	0.1	1.5	-0.2
Medication: Simvastatin	9.2	13.5	51.0	-1.2	6.5	-0.7	2.4	3.5	2.8	-1.9	-1.7	2.6	-7.1
Fluid intelligence score	2.0	4.1	14.0	-1.7	-0.6	-0.1	-2.2	-2.3	-2.3	2.2	-1.9	-3.7	-0.6
Illnesses of siblings	0.6	0.8	4.3	-1.1	0.6	-2.1	-0.6	-0.2	-0.5	0.5	-0.5	-0.1	-0.8
Neuroticism score	0.3	0.6	1.2	0.0	1.0	-0.9	-0.2	-0.4	-0.3	-1.1	-0.8	1.1	0.8
Weight	0.9	4.3	13.5	1.0	-1.2	-2.2	-0.6	-0.9	-0.7	-2.9	-0.2	3.7	3.5
Impedance of arm (right)	0.4	1.8	5.3	0.4	1.0	1.9	0.2	0.6	0.3	2.3	0.6	-2.2	-1.3
Arm fat percentage (right)	1.0	3.9	15.1	0.5	-1.0	-1.9	-0.2	-1.0	-0.4	-2.9	-0.8	3.0	3.9
Trunk fat-free mass	0.3	1.9	10.2	1.0	0.2	-1.5	-0.3	0.2	-0.2	-2.2	-0.0	3.2	1.0
Hip circumference	0.8	3.5	12.6	0.4	-1.7	-1.3	-1.1	-1.4	-1.2	-2.3	-0.6	2.8	3.5
Time employed in main current job	0.6	0.7	3.3	-0.0	-0.7	0.2	-0.6	-1.3	-0.8	-0.5	-0.2	0.9	1.8
Alcohol intake versus 10 years previously	0.8	1.2	3.1	0.1	1.2	1.4	-0.3	0.4	-0.1	1.6	1.8	-0.9	-1.1
Father’s age at death	1.4	1.8	6.9	1.4	-2.0	1.1	0.5	0.7	0.5	0.2	1.5	-0.9	2.6
Worrier / anxious feelings	0.3	0.5	2.5	-1.6	0.4	-0.2	-0.2	-0.9	-0.3	0.1	-1.0	-0.5	0.8
Frequency of tiredness / lethargy in last 2 weeks	0.9	1.5	4.1	-0.5	-0.9	-1.0	-1.7	-2.0	-1.9	-0.4	-0.6	0.9	1.0
Falls in the last year	0.4	0.6	2.0	-0.9	-0.1	-0.5	1.1	0.1	1.0	-0.6	-0.2	0.4	1.4
Hair/balding pattern: Pattern 3	0.1	0.2	0.8	-0.7	-0.4	-0.6	0.1	-0.1	0.0	0.4	-0.3	-0.9	0.2
Number of live births	0.4	0.5	2.3	-0.9	-1.5	-0.2	-0.4	-0.7	-0.5	0.5	0.1	-0.6	0.6
Forced expiratory volume in 1-second (FEV1)	1.5	5.0	16.4	2.6	2.7	1.0	0.1	2.0	0.5	2.8	2.3	-1.4	-4.1
Pulse rate	0.8	1.3	2.5	1.4	-1.0	-0.6	1.4	1.6	1.4	0.6	1.6	-0.6	0.1
Happiness	1.0	1.2	3.9	0.2	1.2	-2.0	-1.3	-1.3	-1.3	0.2	-0.8	0.5	0.2
Noisy workplace	0.8	1.0	3.4	-1.3	-1.9	-0.4	-0.2	-0.4	-0.2	-0.8	-0.7	0.9	1.7
Qualifications: A levels/AS levels or equivalent	0.3	0.7	3.0	-0.3	0.7	0.4	0.6	0.8	0.6	0.8	-1.0	-1.7	-0.9
Serious illness, injury or assault of a close relative in last 2 years	0.7	0.8	1.5	1.1	-0.3	1.0	0.3	1.2	0.4	0.9	1.1	-1.1	-0.8
Mouth/teeth dental problems: Dentures	1.4	2.4	6.0	0.1	0.5	-0.2	2.5	1.6	2.3	-1.9	0.6	1.8	1.4
Asthma	2.6	5.1	14.7	0.4	2.6	-2.7	0.3	0.3	0.3	-3.8	-2.8	3.8	-0.1
Medication: Ibuprofen (e.g. Nurofen)	0.4	0.5	1.1	0.6	-0.9	-1.0	-0.9	-0.5	-0.9	-0.2	-0.9	0.3	0.7
Medication: Cholesterol lowering	6.8	10.6	48.5	-2.5	5.4	-0.3	2.1	2.6	2.4	-1.0	-1.5	1.4	-7.0
Depression (self-reported)	1.1	1.3	5.2	-0.4	-0.3	0.8	0.2	0.3	0.2	-2.0	-0.5	2.3	1.5
Medication: Lansoprazole	0.7	0.8	3.0	-1.7	-0.7	-0.1	-0.2	-1.3	-0.5	-0.0	-0.6	-0.3	1.4
Prospective memory result	0.5	0.6	1.8	0.9	1.0	0.4	-0.0	0.5	0.1	-0.8	0.6	1.3	-0.7
Lung cancer (father)	0.9	1.0	3.9	0.5	-0.5	-0.2	-2.0	-1.3	-1.9	0.1	0.2	0.6	-0.5
Illnesses of mother	1.5	1.9	5.3	1.3	-2.0	-2.3	-1.5	-1.3	-1.6	0.3	0.2	0.2	1.1
Forced expiratory volume in 1-second (FEV1), Best measure	1.1	3.4	16.6	1.5	2.8	-0.5	-0.5	1.2	-0.1	2.0	0.8	-0.4	-4.1
Pulse wave Arterial Stiffness index	0.9	1.0	4.7	1.2	0.0	0.9	-0.7	0.1	-0.6	1.1	1.0	-2.2	-0.2
Impedance of arm (left)	0.5	2.2	8.6	0.0	0.3	2.3	-0.0	0.2	-0.0	2.7	0.9	-2.9	-0.9
Arm fat mass (right)	1.1	4.5	14.1	0.8	-1.3	-2.4	-0.7	-1.3	-0.9	-2.9	-0.7	3.3	3.8
Trunk predicted mass	0.3	2.0	10.3	1.1	0.3	-1.5	-0.3	0.2	-0.2	-2.2	-0.1	3.2	0.9
Standing height	0.1	1.2	4.1	2.0	0.8	0.9	-0.5	0.9	-0.2	1.1	1.8	0.4	-0.8
Length of working week for main job	0.3	0.3	1.1	0.7	-0.1	0.3	-0.6	-0.3	-0.6	0.9	1.0	-0.2	-0.0
Exposure to tobacco smoke at home	3.5	3.9	10.1	-0.2	1.4	-2.2	2.4	1.4	2.2	-2.8	-0.9	3.2	1.3
Breastfed as a baby	0.5	0.7	1.4	-0.8	-0.0	-0.7	-1.2	-0.8	-1.1	-0.5	-0.8	0.4	-1.1
Tense / ‘highly strung’	0.6	1.0	2.0	1.4	1.4	0.8	1.0	1.4	1.1	0.2	0.8	-0.3	-0.6
Seen doctor (GP) for nerves, anxiety, tension or depression	0.4	0.7	1.8	-0.1	-0.9	-0.4	-1.0	-0.8	-1.0	-0.6	-0.1	1.4	1.0
Hair/balding pattern: Pattern 4	0.7	1.6	5.0	-2.2	0.7	-1.4	0.9	0.0	0.8	-1.9	-1.2	1.3	0.9
Birth weight of first child	1.4	2.6	8.5	-1.7	0.9	-2.6	-0.4	-1.1	-0.5	-2.1	-2.9	1.1	0.5
Peak expiratory flow (PEF)	0.2	0.5	2.1	0.9	0.0	0.0	-0.2	0.5	-0.1	-0.0	0.9	0.8	-1.5
Pulse wave reflection index	0.5	0.6	3.6	-0.0	0.2	1.0	-0.2	0.2	-0.1	1.0	0.5	-1.9	-0.2
Ever highly irritable/argumentative for 2 days	1.1	1.3	6.3	2.5	1.7	0.3	-1.0	-0.1	-0.8	0.6	0.9	0.4	-0.9
Loud music exposure frequency	0.5	0.5	2.4	-0.0	0.8	1.6	0.2	-0.2	0.1	0.7	-0.0	-1.1	0.4
Qualifications: O levels/GCSEs or equivalent	1.2	2.0	4.4	1.2	-0.7	1.1	0.8	1.7	1.0	1.7	1.3	-2.1	-1.8
Mouth/teeth dental problems: Bleeding gums	1.2	1.6	5.2	-0.7	-2.3	1.8	0.9	0.3	0.8	0.3	0.4	-1.4	1.9
Blood clot in the leg (DVT)	0.8	1.0	3.9	-0.2	-0.9	-0.7	-1.1	-1.5	-1.2	0.1	-0.2	-0.0	2.0
Medication: Paracetamol	0.6	1.0	2.7	-0.1	-1.6	-1.0	-1.0	-0.7	-0.9	1.2	-0.2	-1.2	1.0
Headache pain in last month	1.6	2.8	5.6	-2.4	-1.0	-2.4	-1.6	-1.9	-1.7	-0.9	-2.1	1.0	0.8
Medication for cholesterol, blood pressure or diabetes	2.1	3.5	11.6	1.1	-3.4	0.6	-1.1	-1.5	-1.3	1.2	0.9	-1.7	3.4
Glaucoma (self-reported)	0.7	0.8	3.1	-0.1	-1.0	0.3	-1.0	-1.7	-1.2	0.7	0.3	-0.5	0.5
Gout (self-reported)	0.8	1.1	3.2	1.2	1.8	-0.9	0.5	1.1	0.7	-0.6	0.4	1.0	-1.5
Hypothyroidism/myxoedema (self-reported)	0.2	0.4	2.0	0.0	-0.4	-1.4	-0.1	-0.4	-0.2	-0.3	-0.7	0.8	-0.6
Medication: Amlodipine	0.4	0.6	1.6	0.7	0.6	-0.3	0.5	0.6	0.6	1.3	0.9	-1.3	-0.3
Medication: Ventolin 100micrograms inhaler	2.1	2.7	7.2	0.0	1.4	-2.3	0.8	0.7	0.8	-2.7	-2.1	2.5	0.2
Birth weight	2.3	5.0	14.7	-2.2	-0.1	-3.8	-1.7	-2.8	-2.0	-1.6	-3.2	1.6	0.3
Chronic bronchitis/emphysema (mother)	0.7	0.8	3.2	0.6	-0.6	-0.5	1.2	0.0	0.9	-1.1	0.1	0.9	1.8
High blood pressure (siblings)	1.1	1.6	6.2	1.0	-1.7	2.5	1.0	0.4	0.9	-0.7	1.2	0.5	1.4
Forced vital capacity (FVC), Best measure	1.1	4.0	16.7	2.0	3.0	-0.1	-0.9	1.0	-0.5	2.5	1.0	-0.6	-4.1
Body fat percentage	1.0	4.0	18.3	0.6	-1.8	-1.8	-0.3	-1.2	-0.6	-2.4	-0.2	2.7	4.3
Leg fat percentage (right)	1.0	3.6	11.9	0.5	-1.2	-2.3	-0.1	-1.0	-0.3	-2.6	-0.3	3.1	3.5
Arm fat-free mass (right)	0.4	2.2	8.2	0.8	-0.9	-1.5	-0.7	-0.6	-0.7	-2.1	0.0	2.9	2.0
Exposure to tobacco smoke outside home	2.0	2.7	4.7	-0.9	1.4	-1.6	2.2	1.7	2.2	-2.1	-0.8	1.9	0.5
Comparative body size at age 10	0.5	1.3	6.2	0.7	1.5	0.9	-0.0	0.9	0.1	0.7	0.9	-1.0	-2.5
Number of full brothers	2.0	2.5	9.8	-1.1	0.8	-0.3	0.2	-0.4	0.1	-3.1	-1.9	2.6	1.6
Worry too long after embarrassment	0.3	0.5	1.3	1.1	1.1	-0.7	-0.5	0.1	-0.4	0.3	0.4	-0.4	-1.0
Seen a psychiatrist for nerves, anxiety, tension or depression	2.1	2.7	4.9	1.4	0.9	0.4	2.1	2.2	2.2	-2.2	0.2	2.2	1.0
Wheeze or whistling in the chest in last year	1.9	3.4	10.5	0.3	1.6	-1.7	1.2	0.5	1.0	-3.2	-1.2	3.0	2.2
Number of children fathered	0.8	0.9	2.5	0.7	0.8	0.0	1.3	1.6	1.4	-1.1	0.1	0.6	-0.3
Reason for reducing amount of alcohol drunk: Health precaution	1.5	1.8	6.6	-0.2	2.0	-0.6	-1.1	-0.6	-1.0	1.5	-1.0	-0.8	-2.6
Age at first live birth	0.8	1.3	3.2	0.9	1.6	1.4	0.6	1.4	0.8	0.6	0.6	-0.9	-1.8
Pulse wave peak to peak time	0.8	1.0	5.1	-1.2	0.2	-1.0	0.5	-0.2	0.4	-1.0	-0.9	2.3	0.1
Health satisfaction	0.9	1.1	4.9	0.5	0.4	-1.2	-1.2	-1.0	-1.2	-0.7	-0.1	2.2	-0.1
Shortness of breath walking on level ground	1.6	1.9	6.7	-0.1	-1.7	-0.2	-0.6	-1.3	-0.8	-1.4	-0.5	2.0	2.6
Qualifications: College or University degree	0.3	0.8	3.3	-1.4	-1.1	0.1	-0.2	-0.7	-0.3	-0.9	-1.8	0.1	0.2
Eye problems/disorders: None of the above	0.7	0.8	1.9	-0.7	-1.2	1.4	0.9	1.0	0.9	0.7	0.6	-0.6	0.3
Mouth/teeth dental problems: Loose teeth	0.1	0.1	0.9	0.3	1.0	-0.7	-0.1	0.0	-0.0	0.1	-0.1	-0.0	0.2
Emphysema/chronic bronchitis	1.8	2.1	4.4	0.0	-2.0	-1.4	-0.8	-1.0	-1.0	-1.8	-0.6	2.1	2.0
Medication for pain relief, constipation, heartburn	0.8	1.3	3.6	1.5	0.6	1.9	1.3	1.2	1.3	-0.0	1.2	-0.6	-0.2
Neck or shoulder pain in last month	0.6	0.9	2.2	-1.3	-0.5	-0.1	-1.4	-1.5	-1.4	0.2	-0.7	0.1	0.4
Medication: Blood pressure	0.4	0.7	2.1	0.4	1.4	-0.1	0.9	1.1	1.0	-0.6	0.1	0.8	-1.0
Angina (self-reported)	2.1	2.8	7.0	-1.1	2.6	-0.7	1.9	1.5	2.0	-1.6	-0.8	2.2	-1.2
Migraine (self-reported)	0.8	1.0	2.9	1.3	0.8	-0.5	0.7	1.2	0.8	0.8	1.0	-0.6	-1.7
Medication: Ibuprofen	0.4	0.5	1.1	1.1	-0.5	-0.7	-1.1	-0.4	-1.0	-0.2	-0.9	0.3	-0.1
Medication: Allopurinol	0.8	1.1	3.7	1.0	1.8	-1.0	-0.8	0.2	-0.6	-0.3	0.1	1.0	-1.9
Medication: Omeprazole	0.9	1.1	2.6	-0.2	-1.4	0.1	-1.4	-1.6	-1.5	-0.2	0.3	0.9	1.4
Medication: Seretide 50 evohaler	2.1	2.5	6.2	-0.7	-0.6	-2.3	-1.0	-1.5	-1.2	-1.6	-2.5	2.0	1.0
Mean time to correctly identify matches	1.6	3.1	8.9	1.0	3.0	-0.5	1.9	2.3	2.1	-2.0	0.5	1.9	-0.0
Heart disease (mother)	1.3	1.6	4.7	-0.4	0.2	0.4	2.2	0.7	2.0	-1.6	0.4	1.1	1.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.4	0.5	1.0	-0.3	-0.2	-1.0	0.9	0.8	0.8	0.1	-0.5	-0.7	-0.9
Whole body fat mass	1.1	4.5	17.1	0.6	-1.6	-2.2	-0.5	-1.2	-0.7	-2.8	-0.4	3.2	4.1
Leg fat mass (right)	1.2	4.6	13.4	0.7	-1.4	-2.5	-0.4	-1.2	-0.6	-3.0	-0.4	3.5	3.7
Arm predicted mass (right)	0.4	2.1	7.7	0.8	-1.0	-1.6	-0.7	-0.6	-0.7	-2.1	-0.2	2.8	1.9
Pulse rate, automated reading	0.3	1.1	4.7	-0.4	-1.4	-1.5	0.3	-0.3	0.1	0.4	0.6	-1.1	2.2
Alcohol intake frequency.	1.0	2.4	10.1	-0.5	0.6	-3.2	-1.5	-1.6	-1.5	-0.9	-0.6	2.1	-0.0
Comparative height size at age 10	0.2	1.3	5.0	2.0	0.5	1.3	-0.5	0.8	-0.3	0.9	2.2	0.3	-0.7
Number of full sisters	2.8	3.4	5.2	-1.9	0.5	-1.9	-1.5	-2.2	-1.7	-2.1	-2.3	2.1	1.7
Suffer from ‘nerves’	0.6	1.0	2.6	-1.0	-0.7	-0.6	-1.1	-1.3	-1.1	-0.8	-1.6	0.6	0.5
Overall health rating	2.3	5.0	23.5	-0.6	0.1	-2.4	0.3	-0.9	0.1	-3.6	-1.5	4.8	2.1
Chest pain or discomfort	1.4	2.0	4.9	0.2	0.6	-2.2	-1.4	-1.6	-1.5	-1.1	-1.7	1.9	0.0
Had major operations	2.9	3.4	7.6	-0.3	2.3	-2.5	0.5	0.3	0.5	-2.6	-2.8	2.6	0.3
Age at last live birth	0.8	1.2	2.9	0.5	1.7	0.8	1.1	1.6	1.2	-0.0	-0.1	0.0	-1.6
Family relationship satisfaction	0.1	0.1	0.6	0.2	0.1	-0.7	0.0	0.1	0.0	-0.3	-0.3	0.8	0.1
Leg pain on walking	1.2	1.5	5.5	-0.0	-1.5	0.7	1.2	0.8	1.1	-1.4	0.5	1.3	2.4
Qualifications: NVQ or HND or HNC or equivalent	0.2	0.2	0.5	0.6	0.2	-0.4	0.4	0.7	0.4	-0.4	0.1	0.1	-0.5
Commuting to job workplace: Car/motor vehicle	0.2	0.2	0.5	-0.6	-0.6	-0.2	-0.1	-0.7	-0.2	-0.3	-0.7	0.1	0.4
Illness, injury, bereavement, stress in last 2 years	0.7	0.8	3.0	0.7	0.8	0.9	-0.5	-0.0	-0.4	1.7	0.9	-1.2	-0.8
Medication: Aspirin	1.6	2.1	5.9	-1.6	1.7	-2.4	0.1	0.1	0.1	-0.6	-1.0	1.7	-2.3
Supplements: Vitamin C	2.7	3.2	10.8	2.2	2.3	0.6	0.7	2.1	1.0	1.5	1.8	-0.3	-3.3
Knee pain experienced in last month	1.3	1.9	4.8	0.1	-0.9	-1.3	-2.1	-2.1	-2.2	-0.7	-1.0	1.3	0.4
Hypertension (Self-reported)	0.5	1.4	3.0	0.5	1.3	-0.3	1.7	1.6	1.7	-1.1	0.5	1.2	-1.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	2.1	2.5	6.0	-1.1	-0.4	-1.9	-1.9	-2.4	-2.1	-0.9	-1.5	1.1	1.2
Illnesses of father: Heart disease	0.5	0.7	4.4	-2.1	0.4	-0.5	-0.0	-0.7	-0.1	0.4	-1.4	-0.2	-0.0
Illnesses of siblings: Diabetes	2.7	3.4	11.0	1.2	0.6	-0.3	1.9	1.2	1.8	-3.0	0.3	3.3	1.9
Smoking status: Previous	1.8	2.8	6.0	1.0	2.2	0.1	1.4	1.5	1.5	1.9	0.6	-2.5	-2.4
Forced expiratory volume in 1-second (FEV1), predicted	0.6	1.3	3.3	-0.7	0.3	-1.7	-1.5	-1.1	-1.4	0.2	-1.8	0.6	-0.6
Whole body fat-free mass	0.4	2.1	9.2	0.9	-0.3	-1.6	-0.5	-0.2	-0.5	-2.3	-0.3	3.0	1.6
Leg fat-free mass (right)	0.4	2.0	6.8	0.7	-0.8	-1.4	-0.4	-0.4	-0.4	-2.3	-0.4	2.6	2.2
Arm fat percentage (left)	1.0	4.1	17.1	0.2	-1.5	-1.8	-0.3	-1.3	-0.6	-2.8	-0.7	2.8	4.1
Average weekly red wine intake	0.7	1.0	3.5	-0.5	-0.2	1.9	1.2	1.4	1.3	-0.9	0.1	-0.5	0.4
Handedness (chirality/laterality): Left-handed	0.9	1.1	2.3	0.0	0.3	-1.5	-1.4	-1.3	-1.4	0.1	-1.0	0.7	-1.2
Mood swings	0.7	1.3	3.2	0.8	1.8	-1.2	-1.5	-1.0	-1.5	-0.1	-0.7	1.1	-0.5
Loneliness, isolation	0.7	1.0	3.4	-0.2	0.4	-1.8	-1.2	-1.1	-1.2	-0.7	-0.9	0.6	0.5
Long-standing illness, disability or infirmity	2.5	3.9	15.6	-0.8	0.6	-2.4	0.3	-0.2	0.2	-3.4	-1.7	3.9	1.2
Ever had bowel cancer screening	0.3	0.4	1.1	0.2	0.7	-0.8	0.4	-0.2	0.3	-0.9	-0.1	0.8	1.1
Diabetes diagnosed by doctor	4.8	7.8	26.5	-1.5	0.5	-3.2	2.4	0.6	2.1	-5.1	-2.2	4.4	2.2
Ever had stillbirth, spontaneous miscarriage or termination	0.5	0.5	2.3	0.9	1.0	-0.1	0.2	0.9	0.4	0.4	0.2	-0.2	-1.5
Friendships satisfaction	0.4	0.5	2.5	0.6	1.6	-0.2	0.9	0.5	0.9	0.3	-0.1	0.0	-0.3
Qualifications: nursing, teaching	1.3	2.1	4.1	-1.6	-2.0	-0.8	-1.1	-2.0	-1.4	0.1	-1.9	-0.7	1.6
Commuting to job workplace: Walk	0.5	0.5	1.5	0.4	1.2	0.1	-0.8	-0.6	-0.8	-0.6	0.3	1.0	0.0
Eye problems/disorders: Cataract	1.1	1.3	4.8	-0.2	1.5	-2.2	-0.8	-1.0	-0.8	-1.0	-1.3	1.1	0.1
Mouth/teeth dental problems: Mouth ulcers	1.6	2.6	6.7	-1.5	-1.0	0.3	2.6	1.1	2.4	-1.7	-1.0	0.6	2.1
Medication for cholesterol	1.9	2.9	17.6	0.9	-2.0	1.1	-0.6	-1.2	-0.8	0.7	1.0	-1.4	4.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	2.5	2.9	6.0	-1.6	0.4	-2.3	-1.6	-2.1	-1.8	-1.6	-2.5	1.4	0.3
Back pain experienced in last month	1.0	1.4	3.7	1.0	-0.7	-1.1	-1.6	-0.8	-1.5	-1.3	-0.1	1.9	0.7
Mineral and other dietary supplements	0.4	0.5	2.2	-0.2	-1.3	0.5	0.2	-0.6	0.1	-0.5	0.1	0.6	1.5
Breast cancer (self-reported)	1.3	1.6	3.0	0.6	1.1	-0.7	1.5	1.6	1.6	-1.7	-0.6	1.7	-0.4
Asthma (self-reported)	2.8	5.5	15.7	0.5	2.9	-2.8	0.5	0.5	0.5	-3.9	-2.8	4.0	-0.1
Osteoporosis (self-reported)	0.6	0.7	2.8	-0.7	-0.3	-1.7	-0.5	-0.6	-0.5	-0.7	-1.4	0.3	0.2
Osteoarthritis (self-reported)	0.4	0.5	1.7	0.6	0.1	-0.6	-1.3	-0.9	-1.3	0.3	-0.4	-0.6	-0.4
Medication: Aspirin	1.4	1.9	5.4	-1.1	1.8	-1.8	0.3	0.5	0.4	-0.8	-0.7	1.9	-2.3
Medication: Gliclazide	2.3	2.6	7.8	-0.4	1.4	-1.0	1.5	1.7	1.6	-2.8	-0.6	2.7	-0.2
Illnesses of father: None of the above (group 1)	1.3	1.6	6.4	2.5	0.5	0.2	0.5	1.8	0.8	0.1	2.1	-0.2	-0.7
Smoking status: Current	1.3	2.1	7.1	0.6	-0.9	0.2	1.6	1.0	1.5	-1.9	0.0	1.9	2.7
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.5	3.2	15.4	1.3	3.2	-1.6	-0.5	0.6	-0.3	0.5	-0.1	0.8	-3.9
Whole body water mass	0.4	2.2	9.6	1.0	-0.2	-1.6	-0.5	-0.2	-0.4	-2.3	-0.2	3.1	1.6
Leg predicted mass (right)	0.4	2.0	7.0	0.7	-0.8	-1.4	-0.4	-0.4	-0.4	-2.3	-0.4	2.6	2.2
Arm fat mass (left)	1.1	4.5	14.5	0.6	-1.4	-2.1	-0.8	-1.5	-1.0	-2.9	-0.6	3.3	3.8
Number of self-reported non-cancer illnesses	2.1	3.7	7.8	-0.9	2.5	-1.2	1.7	2.2	1.9	-2.8	-1.2	2.6	-1.1
Average weekly champagne plus white wine intake	0.4	0.5	1.7	0.9	-0.1	-0.1	0.9	1.3	1.0	-0.7	-0.2	0.6	-0.2
Miserableness	0.6	1.0	4.0	0.1	-1.1	0.1	-0.3	-0.8	-0.5	-0.7	0.2	1.9	2.0
Guilty feelings	0.4	0.6	2.0	0.8	1.4	-0.7	0.6	0.5	0.6	-0.6	-0.9	0.1	1.0
Wears glasses or contact lenses	0.4	0.4	1.6	-0.6	-0.7	0.8	0.6	-0.0	0.4	-0.4	-0.4	-0.6	1.3
Ever taken oral contraceptive pill	1.4	1.6	4.2	-0.5	2.1	-1.8	1.5	1.1	1.5	-0.3	-1.2	-0.7	-0.6
Hearing aid user	0.3	0.3	0.9	0.6	1.0	-0.4	0.2	0.4	0.3	0.7	1.0	-0.3	-0.2
Mother’s age at death	1.4	1.7	8.0	-1.1	-1.2	-0.9	0.7	-0.6	0.4	-1.6	-1.2	0.4	2.8
Financial situation satisfaction	0.3	0.3	2.0	1.4	0.1	-0.3	-0.1	0.5	0.1	0.4	0.6	0.5	-0.4
Tinnitus: Yes, now most or all of the time	0.9	1.1	4.6	-0.5	0.7	-1.8	0.2	-0.0	0.2	-1.1	-1.0	2.1	0.4
Commuting to job workplace: Public transport	1.4	1.7	4.4	0.9	1.3	1.0	0.3	0.8	0.3	2.1	1.3	-2.1	-1.5
Eye problems/disorders: Glaucoma	0.7	0.8	1.8	0.1	-1.3	0.7	-1.1	-1.1	-1.1	1.0	0.8	-0.7	-0.2
Medication: Blood pressure	0.4	0.7	1.6	-0.3	0.3	-0.2	1.1	1.2	1.1	-0.7	0.7	0.7	-1.3
Pain type(s) experienced in last month: Hip pain	1.5	1.8	6.4	0.1	-0.7	0.6	0.4	-0.3	0.3	-2.1	-0.0	2.5	2.5
Supplements: Fish oil (including cod liver oil)	1.4	1.8	5.6	1.3	1.2	0.7	0.4	1.8	0.7	1.2	1.2	-1.5	-2.4
High cholesterol (Self-reported)	14.5	25.7	130.0	-2.3	8.8	-1.1	2.3	4.0	2.9	-1.1	-2.1	2.6	-11.4
Medication: Bendroflumethiazide	0.2	0.3	1.3	-0.8	-1.1	-0.0	0.3	0.0	0.2	0.4	-0.0	-0.6	0.4
Medication: Paracetamol	0.8	1.3	2.8	-0.1	-1.7	-1.0	-1.3	-1.1	-1.3	1.3	-0.5	-1.4	0.7
Medication: Lisinopril	1.1	1.4	3.2	0.4	1.8	0.4	1.4	1.6	1.5	0.4	0.4	-0.9	-1.8
Medication: Atorvastatin	4.5	5.6	26.3	-2.5	4.0	-1.4	0.5	0.5	0.6	-0.2	-1.7	1.3	-5.1
Illnesses of father: High blood pressure	0.3	0.4	1.0	-0.1	-0.6	-0.1	-0.9	-1.0	-1.0	-0.0	-0.3	0.3	0.8
Alcohol drinker status: Never	0.2	0.3	0.7	0.7	0.1	-0.4	-0.0	0.5	0.1	-0.0	0.7	0.8	-0.8
Ever smoked	0.7	1.3	2.1	1.1	1.3	-0.7	1.2	1.2	1.2	1.1	0.3	-1.4	-1.4
Basal metabolic rate	0.5	2.6	10.5	1.1	-0.5	-1.8	-0.6	-0.4	-0.6	-2.4	-0.2	3.2	2.0
Leg fat percentage (left)	1.0	3.6	12.6	0.3	-1.2	-2.2	-0.0	-1.0	-0.3	-2.6	-0.4	3.0	3.5
Arm fat-free mass (left)	0.5	2.4	9.9	1.0	-0.3	-2.0	-0.9	-0.6	-0.9	-2.1	-0.3	3.1	1.5
Number of operations (self-reported)	1.6	2.4	6.9	-0.6	0.9	-2.3	1.1	0.5	1.1	-2.6	-1.8	1.8	1.1
Average weekly beer plus cider intake	0.5	0.8	3.2	1.0	1.8	-0.3	0.8	1.2	0.9	0.3	0.5	0.2	-0.7
Irritability	0.8	1.4	4.3	1.1	2.1	-1.3	-0.2	0.2	-0.1	-1.4	-0.2	2.1	-0.1
Risk taking	0.5	0.8	3.4	0.3	-0.2	-0.4	-0.5	-0.9	-0.6	-0.9	-1.2	0.5	1.8
Ever had prostate specific antigen (PSA) test	0.5	0.6	2.6	-0.2	1.1	-1.6	0.5	0.2	0.5	-1.0	-0.7	0.5	0.4
Fractured/broken bones in last 5 years	0.4	0.5	1.5	-1.2	-1.0	0.4	0.4	-0.1	0.3	-0.2	-0.2	-0.3	1.2
Age started oral contraceptive pill	0.3	0.3	1.2	-0.2	0.4	0.2	0.7	0.5	0.7	-0.5	1.1	0.2	-0.5
Diastolic blood pressure, automated reading	0.4	1.1	4.5	2.1	1.3	0.1	-0.5	0.2	-0.4	0.6	1.9	-0.8	0.2
Ever depressed for a whole week	0.6	0.8	2.9	1.5	-0.4	0.0	-0.8	-0.6	-0.8	-0.5	0.5	1.7	0.7
Unable to work because of sickness or disability	0.7	0.8	3.0	-0.9	-0.3	-1.1	0.4	0.0	0.4	-1.5	-0.6	1.7	0.8
Commuting to job workplace: Cycle	2.3	2.8	7.1	2.1	2.4	0.0	1.6	2.7	1.9	0.3	0.7	-0.2	-2.0
Myopia	0.8	1.2	4.0	-0.1	-0.0	1.8	1.2	0.7	1.1	-0.9	0.3	-0.2	2.0
Vascular/heart problems diagnosed by doctor	1.0	2.8	5.4	-0.4	-2.3	0.2	-2.2	-2.3	-2.3	1.5	-0.6	-1.7	1.4
Cholesterol lowering medication	8.9	13.1	53.7	-2.3	5.5	-1.2	2.2	3.0	2.5	-2.1	-2.0	3.4	-7.3
Medication: Omeprazole (e.g. Zanprol)	0.4	0.5	1.1	0.1	-0.5	0.2	-1.0	-1.0	-1.1	0.0	0.4	0.7	0.8
Pain experienced in last month	1.0	1.7	5.3	0.1	0.4	1.7	1.7	1.1	1.6	1.1	1.1	-2.3	0.2
Supplements: Calcium	0.5	0.6	1.9	0.6	0.2	-0.3	-1.4	-1.2	-1.4	0.5	-0.2	-0.1	0.1
Basal cell carcinoma (self-reported)	0.6	0.7	1.6	0.9	-0.1	0.3	1.1	1.1	1.1	0.6	0.7	-1.3	-0.1
Heart attack/myocardial infarction (self-reported)	0.9	1.1	2.8	-1.7	1.2	-1.1	0.5	0.6	0.6	-0.7	-0.5	1.4	-1.5
Deep venous thrombosis (DVT) (self-reported)	0.7	0.9	4.0	-0.1	-1.3	-0.3	-0.8	-1.3	-1.0	0.2	0.1	-0.1	2.0
Heart disease (siblings)	0.6	0.7	3.3	-1.0	-0.9	0.9	0.2	-0.2	0.1	1.0	0.0	-1.8	-0.3
Alcohol drinker status: Previous	1.7	1.9	7.7	-0.8	0.7	-2.8	-1.2	-1.2	-1.2	-1.1	-1.6	1.6	-0.3
Pack years of smoking	1.6	2.3	5.4	0.9	-0.5	-0.7	2.1	1.6	2.0	-1.6	1.3	2.3	0.9
Impedance of whole body	0.6	3.1	11.2	0.1	0.1	2.4	-0.2	0.1	-0.2	3.3	1.2	-3.3	-1.2
Leg fat mass (left)	1.2	4.6	13.2	0.7	-1.3	-2.5	-0.4	-1.2	-0.6	-3.1	-0.4	3.6	3.6
Arm predicted mass (left)	0.5	2.3	9.7	1.3	-0.3	-1.9	-0.6	-0.3	-0.6	-2.2	-0.1	3.1	1.6