TWAS
hub
About
Usage
Models
Genes
Traits
[Hub]/) :
Traits
:
Cardiovascular Disease
:
←
chr22:28,794,069-30,261,219
Best TWAS P=5.66e-12 · Best GWAS P=2.6e-08 conditioned to 0.0865
28.8M
29M
29.2M
29.4M
29.6M
29.8M
30M
30.2M
0
2
4
6
8
physical position
-log10 P
Conditional
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
4
The Cancer Genome Atlas
Skin Cutaneous Melanoma
ZNRF3
0.44
-0.01
blup
126
0.05
2.0e-02
1.4
-6.9
5.7e-12
0.26
0.01
0.16
TRUE
2
The Cancer Genome Atlas
Breast Invasive Carcinoma
C22orf31
0.04
0.02
blup
67
0.01
2.6e-03
-5.1
5.7
1.5e-08
-0.40
0.03
0.84
TRUE
3
The Cancer Genome Atlas
Kidney Renal Clear Cell Carcinoma
KREMEN1
0.13
0.10
lasso
5
0.11
3.3e-12
-5.0
-5.4
5.2e-08
0.56
0.03
0.96
FALSE
1
GTEx
Heart Left Ventricle
KREMEN1
0.47
0.32
lasso
6
0.34
5.0e-19
-5.0
-5.1
3.0e-07
0.59
0.07
0.93
FALSE