Best TWAS P=5.66e-12 · Best GWAS P=2.6e-08 conditioned to 0.0865
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Heart Left Ventricle | KREMEN1 | 0.47 | 0.32 | lasso | 6 | 0.34 | 5.0e-19 | -5.0 | -5.1 | 3.0e-07 | 0.59 | 0.07 | 0.93 | FALSE |
| 2 | The Cancer Genome Atlas | Breast Invasive Carcinoma | C22orf31 | 0.04 | 0.02 | blup | 67 | 0.01 | 2.6e-03 | -5.1 | 5.7 | 1.5e-08 | -0.40 | 0.03 | 0.84 | TRUE |
| 3 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | KREMEN1 | 0.13 | 0.10 | lasso | 5 | 0.11 | 3.3e-12 | -5.0 | -5.4 | 5.2e-08 | 0.56 | 0.03 | 0.96 | FALSE |
| 4 | The Cancer Genome Atlas | Skin Cutaneous Melanoma | ZNRF3 | 0.44 | -0.01 | blup | 126 | 0.05 | 2.0e-02 | 1.4 | -6.9 | 5.7e-12 | 0.26 | 0.01 | 0.16 | TRUE |