TWAS hub - C22orf31

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	TCGA	Breast Invasive Carcinoma	0.0374	0.0181	0.00093	0.021	0.010	0.003	NA	0.003	3.4e-05	0.00260	0.0780	NA	0.070
2	TCGA	Colon Adenocarcinoma	0.0710	0.0360	0.00073	0.017	0.059	0.039	NA	0.023	3.4e-02	0.00027	0.0026	NA	0.017

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Waist Hip Ratio (WHR)	8.2	36.7	73.0	8.5	-0.6
Heel bone mineral density (BMD) T-score, automated (left)	8.0	18.0	35.6	0.7	6.0
Eye problems/disorders: Glaucoma	7.7	9.1	14.9	3.9	-1.8
Heel T-Score	7.3	58.5	116.6	-0.5	10.8
High blood pressure	6.3	17.5	26.3	5.1	-3.0
Glaucoma (self-reported)	6.1	7.1	10.5	3.2	-1.9
Cardiovascular Disease	5.7	18.8	32.1	5.7	-2.3
Heel bone mineral density (BMD) T-score, automated (right)	5.7	13.2	26.2	0.3	5.1
Illness, injury, bereavement, stress in last 2 years	5.7	7.0	13.9	-3.7	-0.2
Emphysema/chronic bronchitis	5.6	6.3	11.6	3.4	0.9
Hypertension (Self-reported)	5.4	15.0	23.9	4.9	-2.4
Medication: Lisinopril	5.3	6.8	11.0	3.3	1.6
Hair/balding pattern: Pattern 4	5.1	12.3	16.0	-4.0	-2.9
Illnesses of father: High blood pressure	4.8	6.0	11.5	3.4	0.7
Systolic Blood Pressure	4.7	23.6	46.2	6.8	-1.0
Eye problems/disorders: None of the above	4.7	5.4	10.8	-3.3	0.0
Vascular/heart problems diagnosed by doctor	4.6	12.4	18.0	-4.2	2.6
Chest pain or discomfort	4.4	6.4	10.7	3.3	1.5
Major Depression (MDD)	4.0	4.8	6.3	2.5	1.8
Crohns Disease (2012)	3.7	6.0	10.3	3.2	1.3
Systolic blood pressure, automated reading	3.7	10.8	20.8	4.6	-0.9
Qualifications: CSEs or equivalent	3.6	4.7	7.8	2.8	1.3
Irritable Bowel Disease (IBD)	3.5	8.4	11.9	3.5	2.2
Myopia	3.5	5.1	8.6	-1.3	-2.9
Crohns Disease (2017)	3.3	7.3	12.4	3.5	1.5
Tinnitus: Yes, but not now, but have in the past	3.2	3.4	5.7	2.4	1.0
Medication: Blood pressure	3.2	5.6	10.2	3.2	-1.1
Diastolic blood pressure, automated reading	3.2	9.9	19.3	4.4	-0.8
Medication: Atenolol	3.1	3.9	7.5	2.7	-0.4
Medication for cholesterol, blood pressure or diabetes	3.1	5.1	10.1	-3.2	0.2
HDL Cholesterol	3.0	5.1	10.1	-3.2	-0.2
Lung FEV1/FVC ratio	3.0	15.2	23.6	4.9	2.6
Impedance of arm (right)	2.9	13.5	23.7	-4.9	1.8
Medication for cholesterol	2.8	4.2	6.1	-2.5	1.5
Medication: Cholesterol lowering	2.7	4.2	7.4	2.7	1.0
Illnesses of father: None of the above (group 1)	2.7	3.3	6.2	-2.5	-0.6
Pain type(s) experienced in last month: Hip pain	2.6	3.3	6.4	0.3	-2.5
Ever used hormone-replacement therapy (HRT)	2.5	3.2	4.8	-1.2	-2.2
Impedance of arm (left)	2.5	11.5	20.0	-4.5	1.7
Birth weight	2.5	5.5	9.5	-1.2	3.1
Depression (Nagel 2018)	2.4	3.6	4.0	1.8	-2.0
Commuting to job workplace: Car/motor vehicle	2.4	2.8	4.9	2.2	0.9
Ulcerative Colitis (UC)	2.3	4.4	4.8	2.0	2.2
Prospective memory result	2.3	2.8	3.2	-1.6	-1.8
Financial situation satisfaction	2.3	2.8	5.2	2.3	0.6
Qualifications: O levels/GCSEs or equivalent	2.2	3.5	6.8	0.5	2.6
Medication: Aspirin	2.2	2.8	4.9	2.2	-0.9
Medication: Aspirin	2.2	2.8	5.2	2.3	-0.6
Medication: Blood pressure	2.2	4.2	5.6	2.4	-1.7
Financial difficulties in last 2 years	2.1	2.8	5.5	2.3	-0.3
Mouth/teeth dental problems: Dentures	2.1	3.6	6.2	1.0	2.5
Number of full brothers	2.1	2.6	4.1	2.0	-1.1
Pulse wave peak to peak time	2.1	2.5	4.5	0.6	2.1
Guilty feelings	2.1	3.1	6.1	0.3	-2.5
Ulcerative Colitis	2.0	2.9	4.4	2.1	1.2
Reason for reducing amount of alcohol drunk: Health precaution	2.0	2.3	3.8	-1.9	-0.9
Number of self-reported non-cancer illnesses	2.0	3.5	3.5	1.9	-1.9
Rheumatoid Arthritis	1.9	2.7	4.7	-0.8	2.2
Frequency of depressed mood in last 2 weeks	1.9	2.6	4.1	2.0	-1.0
Medication: Co-codamol	1.9	2.2	3.0	1.2	-1.7
Severe depression (siblings)	1.9	2.2	3.9	-2.0	-0.7
Headache pain in last month	1.9	3.2	3.5	1.7	1.9
Long-standing illness, disability or infirmity	1.9	2.9	5.5	2.3	-0.6
Other serious medical condition/disability diagnosed by doctor	1.8	2.3	3.4	1.8	-1.1
Trunk fat percentage	1.8	7.2	13.8	-3.7	-0.7
Angina	1.7	2.2	4.0	2.0	0.6
Had other major operations	1.7	2.1	3.9	0.4	-2.0
Pulse wave Arterial Stiffness index	1.7	1.9	3.4	-0.7	-1.8
Medication: Allopurinol	1.7	2.3	2.5	1.6	-1.4
Had major operations	1.7	2.0	3.0	1.7	1.0
Diabetes diagnosed by doctor	1.7	2.7	3.7	1.9	-1.3
LDL Cholesterol	1.6	2.5	4.9	2.2	0.3
Number of treatments/medications taken	1.6	2.9	5.6	2.4	-0.4
Had menopause	1.6	2.0	2.8	-1.7	-1.1
Diabetes (self-reported)	1.6	2.5	3.7	1.9	-1.1
Time employed in main current job	1.6	1.9	3.6	-1.9	-0.4
Worrier / anxious feelings	1.6	3.0	5.9	2.4	0.2
High blood pressure (siblings)	1.6	2.4	4.7	2.2	0.1
Medication: Bendroflumethiazide	1.6	2.5	3.7	1.9	-1.1
Medication: Metformin	1.5	2.1	2.3	1.5	-1.4
Serious illness, injury or assault to yourself	1.5	1.9	3.7	1.9	0.1
Qualifications: A levels/AS levels or equivalent	1.5	3.3	6.6	-0.1	2.6
Age at first live birth	1.5	2.7	4.8	0.8	2.2
Angina (self-reported)	1.5	1.9	3.6	1.9	0.4
Back pain experienced in last month	1.5	2.3	2.5	1.6	1.4
Heart disease (siblings)	1.5	1.9	3.8	1.9	-0.1
High blood pressure (mother)	1.4	1.9	3.8	1.9	0.3
Fluid intelligence score	1.4	3.0	5.5	-0.7	2.3
Serious illness, injury or assault of a close relative in last 2 years	1.4	1.6	3.1	1.8	-0.3
Number of full sisters	1.4	1.7	2.6	-1.6	-0.8
Commuting to job workplace: Cycle	1.4	1.6	3.3	-1.8	-0.1
Cholesterol lowering medication	1.4	2.0	4.0	0.0	-2.0
Deep venous thrombosis (DVT) (self-reported)	1.4	1.9	2.6	1.0	1.6
Schizophrenia vs Biploar Disorder	1.3	1.7	2.3	1.5	-1.0
Alzheimer’s Disease (including proxy)	1.3	1.9	3.6	0.6	1.9
Lupus	1.3	1.9	3.4	1.8	0.7
Hand grip strength (left)	1.3	3.5	4.3	2.1	1.6
Frequency of tenseness / restlessness in last 2 weeks	1.3	2.0	2.2	1.5	-1.4
Arm fat percentage (right)	1.3	5.2	10.1	-3.2	-0.5
Number of live births	1.3	1.8	2.7	1.7	-0.9
Arm fat percentage (left)	1.3	5.3	10.1	-3.2	-0.6
Coronary Artery Disease (CAD)	1.2	1.5	2.3	0.8	-1.5
HbA1C	1.2	1.4	2.3	1.5	0.7
Type 2 Diabetes (T2D) (2012)	1.2	1.4	2.5	0.4	-1.6
Vitamin and mineral supplements	1.2	1.6	2.8	0.6	1.7
Multivitamins +/- minerals	1.2	1.5	3.0	-0.3	-1.7
Chronic bronchitis/emphysema (father)	1.2	1.4	1.5	1.2	1.2
Medication: Simvastatin	1.2	1.7	3.1	1.8	-0.6
Illnesses of siblings	1.2	1.7	2.8	-1.7	0.8
Alcohol intake versus 10 years previously	1.2	1.8	1.8	-1.3	-1.3
Body fat percentage	1.2	4.7	8.6	-2.9	-0.9
Wheeze or whistling in the chest in last year	1.2	2.2	4.4	2.1	-0.2
Commuting to job workplace: Public transport	1.2	1.4	1.4	-1.2	1.2
Supplements: Fish oil (including cod liver oil)	1.2	1.5	2.2	-1.5	-1.0
Alcohol drinker status: Never	1.2	1.4	1.7	1.0	1.3
Neuroticism (Nagel 2018)	1.1	2.6	4.4	2.1	-0.9
Worry (Nagel 2018)	1.1	2.3	4.6	2.1	0.2
Reaction Time	1.1	2.1	2.4	-1.3	1.5
Prostate Cancer	1.1	1.5	3.1	1.8	-0.1
Current tobacco smoking	1.1	1.7	3.4	0.3	-1.8
Trunk fat mass	1.1	4.7	8.9	-3.0	-0.8
Breastfed as a baby	1.1	1.4	2.5	-0.5	-1.6
Blood clot in the leg (DVT)	1.1	1.4	1.8	1.0	1.3
Number of children fathered	1.1	1.3	2.2	1.5	-0.6
Leg pain on walking	1.1	1.3	2.7	-1.6	-0.2
Friendships satisfaction	1.1	1.4	2.1	-0.8	-1.4
Tinnitus: Yes, now most or all of the time	1.1	1.3	2.6	-0.1	1.6
Average weekly fortified wine intake	1.0	1.2	1.6	-0.9	-1.3
Hayfever/allergic rhinitis (self-reported)	1.0	1.3	2.4	-0.6	1.5
Frequency of tiredness / lethargy in last 2 weeks	1.0	1.6	2.8	-0.7	-1.7
Seen a psychiatrist for nerves, anxiety, tension or depression	1.0	1.3	2.6	0.1	1.6
Medication: Seretide 50 evohaler	1.0	1.2	2.4	1.5	0.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.0	1.2	2.5	0.1	-1.6
Family relationship satisfaction	1.0	1.2	1.5	1.2	-1.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.0	1.1	2.3	1.5	-0.1
Ever had bowel cancer screening	1.0	1.2	2.3	-0.2	-1.5
Commuting to job workplace: Walk	1.0	1.1	2.0	-1.4	-0.5
Eye problems/disorders: Cataract	1.0	1.2	2.3	1.5	0.2
Smoking status: Current	1.0	1.6	3.2	0.1	-1.8
Medication: Atorvastatin	1.0	1.3	1.4	1.1	-1.2
Triglycerides	0.9	1.4	2.8	1.7	0.1
Blood Red Count	0.9	8.7	9.2	3.0	2.9
Smoking Status	0.9	2.2	3.4	-1.0	-1.9
Neuroticism	0.9	2.3	4.5	2.1	-0.1
Ever had hysterectomy (womb removed)	0.9	1.1	1.3	0.9	1.2
Maternal smoking around birth	0.9	1.3	1.6	-1.0	-1.3
Hip circumference	0.9	3.9	7.7	-2.8	-0.3
Exposure to tobacco smoke at home	0.9	1.0	2.0	-1.4	-0.2
Medication: Amlodipine	0.9	1.3	1.6	1.0	-1.3
Overall health rating	0.9	1.9	2.2	1.3	-1.5
Age at last live birth	0.9	1.3	2.2	0.7	1.5
Handedness (chirality/laterality): Left-handed	0.9	1.1	1.5	0.8	1.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.9	1.1	1.6	-0.7	-1.3
Number of operations (self-reported)	0.9	1.4	2.7	1.6	-0.0
Ever depressed for a whole week	0.9	1.2	1.9	0.7	-1.4
Pain experienced in last month	0.9	1.5	2.8	-1.7	-0.5
Impedance of whole body	0.9	4.7	8.1	-2.8	1.2
Depressed Affect (Nagel 2018)	0.8	1.6	2.9	1.7	-0.5
Hypothyroidism (self reported)	0.8	1.8	3.6	0.0	1.9
Relative age of first facial hair	0.8	1.7	3.4	-1.8	0.2
Frequency of unenthusiasm / disinterest in last 2 weeks	0.8	1.1	2.0	0.5	-1.4
Pulse rate	0.8	1.4	2.5	-0.4	-1.6
Whole body fat mass	0.8	3.2	5.7	-2.4	-0.9
Average weekly red wine intake	0.8	1.3	2.4	0.3	1.6
Mouth/teeth dental problems: Mouth ulcers	0.8	1.3	1.5	-1.1	-1.2
Unable to work because of sickness or disability	0.8	1.0	1.8	1.3	-0.4
Medication: Omeprazole (e.g. Zanprol)	0.8	1.0	1.9	-0.1	-1.4
Allergy or Eczema	0.7	1.8	3.3	-0.5	1.8
Type 2 Diabetes (T2D) (2018)	0.7	1.3	1.8	0.9	-1.3
Medication for hormone replacement therapy	0.7	0.8	1.5	0.4	-1.2
Stomach or abdominal pain in last month	0.7	0.9	1.0	0.9	1.0
Arm fat mass (right)	0.7	2.9	5.0	-2.2	-0.8
Forced vital capacity (FVC), Best measure	0.7	2.6	4.5	-2.1	0.8
Mouth/teeth dental problems: Loose teeth	0.7	0.8	1.7	-0.1	-1.3
Mean time to correctly identify matches	0.7	1.3	2.2	-1.5	0.7
Qualifications: NVQ or HND or HNC or equivalent	0.7	0.8	1.6	1.3	-0.3
Loneliness, isolation	0.7	0.9	1.4	1.2	-0.6
Qualifications: nursing, teaching	0.7	1.1	1.5	1.2	0.9
Medication: Gliclazide	0.7	0.8	1.0	0.8	-1.0
Leg fat percentage (left)	0.7	2.5	3.6	-1.2	-1.9
Fractured/broken bones in last 5 years	0.7	0.9	1.7	1.3	0.4
Age started oral contraceptive pill	0.7	0.9	1.3	-1.1	0.7
Leg fat mass (left)	0.7	2.7	3.1	-1.5	-1.8
Intelligence (Savage-Jansen 2018)	0.6	1.8	3.5	-1.9	0.2
Alzheimer’s Disease (in mother)	0.6	0.7	1.2	0.4	1.1
Age at First Birth	0.6	0.9	1.7	0.3	1.3
Relative age voice broke	0.6	1.0	1.8	-1.3	0.4
Medication: Levothyroxine sodium	0.6	1.1	2.1	0.3	1.4
Sitting height	0.6	4.2	4.5	-2.0	2.1
Waist circumference	0.6	2.2	4.2	2.0	-0.5
Nervous feelings	0.6	1.0	2.1	1.4	-0.2
Qualifications: None of the above	0.6	1.3	1.9	-0.8	-1.4
Neuroticism score	0.6	1.2	2.1	1.4	-0.5
Hair/balding pattern: Pattern 3	0.6	0.9	1.0	-0.9	1.0
Length of working week for main job	0.6	0.7	1.1	-0.6	1.0
Medication for pain relief, constipation, heartburn	0.6	1.0	1.8	-1.3	0.5
Medication: Ibuprofen	0.6	0.7	1.4	-0.2	1.2
Forced expiratory volume in 1-second (FEV1), predicted	0.6	1.1	1.3	-1.1	1.0
Arm fat mass (left)	0.6	2.6	4.8	-2.2	-0.7
Hair Pigment	0.5	15.4	24.8	5.0	-2.5
Sensitivity / hurt feelings	0.5	0.8	1.2	0.7	-1.1
Past tobacco smoking	0.5	0.9	1.0	1.0	0.8
Alcohol usually taken with meals	0.5	0.8	1.2	0.6	1.1
Pain all over the body in last month	0.5	0.5	1.0	-0.1	-1.0
Father’s age at death	0.5	0.7	1.3	1.1	0.4
Hypothyroidism/myxoedema (self-reported)	0.5	1.0	1.1	-1.0	1.0
Exposure to tobacco smoke outside home	0.5	0.6	0.8	-0.9	0.7
Leg fat mass (right)	0.5	2.0	2.4	-1.3	-1.5
Supplements: Vitamin C	0.5	0.6	1.1	-1.1	-0.3
Risk taking	0.5	0.7	1.4	1.2	-0.2
Supplements: Calcium	0.5	0.6	1.1	-1.1	-0.1
Alzheimer’s Disease (in father)	0.4	0.4	0.7	0.8	0.4
Verbal and Numeric Reasoning (VNR)	0.4	1.0	1.7	-1.3	0.6
Neuroticism (2016)	0.4	0.6	1.0	0.5	-1.0
Chronotype (morning person)	0.4	1.0	1.8	-1.3	-0.4
Diabetes (father)	0.4	0.4	0.8	-0.3	-0.9
Pack years adult smoking proportion	0.4	0.6	1.0	1.0	0.4
Hand grip strength (right)	0.4	1.0	1.5	1.2	0.7
Supplements: Glucosamine	0.4	0.6	1.0	1.0	0.4
Hearing difficulty/problems with background noise	0.4	0.7	1.3	0.3	-1.1
Mouth/teeth dental problems	0.4	0.7	1.1	-0.5	-1.1
Trunk fat-free mass	0.4	2.1	4.1	2.0	-0.2
Medication: Ibuprofen (e.g. Nurofen)	0.4	0.5	0.8	-0.4	0.9
Trunk predicted mass	0.4	2.1	4.2	2.0	-0.1
Leg fat percentage (right)	0.4	1.5	2.4	-0.8	-1.6
Arm fat-free mass (right)	0.4	2.1	2.8	1.7	-1.2
Worry too long after embarrassment	0.4	0.6	0.7	0.7	-0.8
Qualifications: College or University degree	0.4	1.2	2.0	-1.4	0.7
Neck or shoulder pain in last month	0.4	0.6	0.8	0.9	-0.6
Migraine (self-reported)	0.4	0.5	0.9	0.4	1.0
Arm predicted mass (right)	0.4	2.0	2.9	1.7	-1.1
Illnesses of siblings: Diabetes	0.4	0.5	0.9	-0.4	-0.9
Ever taken oral contraceptive pill	0.4	0.4	0.8	0.9	0.2
High cholesterol (Self-reported)	0.4	0.8	1.2	1.1	-0.6
Average weekly beer plus cider intake	0.4	0.5	0.7	0.6	-0.8
Ever had prostate specific antigen (PSA) test	0.4	0.5	0.8	0.9	-0.4
Bipolar Disorder (2018)	0.3	0.5	1.1	-0.1	1.0
Body Mass Index (BMI) (2010)	0.3	0.4	0.8	0.9	-0.1
Height	0.3	6.0	8.4	-2.9	1.9
Eye problems/disorders: Diabetes related eye disease	0.3	0.4	0.7	0.8	-0.1
Fed-up feelings	0.3	0.6	1.3	1.1	-0.0
Age when periods started (menarche)	0.3	0.8	1.1	-0.6	1.0
Hayfever, allergic rhinitis or eczema	0.3	0.6	0.8	-0.6	0.9
Body mass index (BMI)	0.3	1.4	1.6	-1.1	-1.3
Number of incorrect matches in round	0.3	0.4	0.5	0.7	-0.6
Forced vital capacity (FVC)	0.3	1.3	1.6	-1.3	1.0
Ever unenthusiastic/disinterested for a whole week	0.3	0.4	0.4	0.6	-0.6
Heart attack	0.3	0.3	0.6	-0.8	-0.2
Allergy	0.3	0.8	1.2	-0.6	-1.1
Weight	0.3	1.7	2.7	-1.7	-0.8
Medication: Lansoprazole	0.3	0.4	0.7	-0.8	-0.2
Illnesses of mother	0.3	0.4	0.5	-0.7	-0.5
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	1.1	1.7	-0.7	1.3
Pulse wave reflection index	0.3	0.4	0.5	0.6	-0.7
Gout (self-reported)	0.3	0.4	0.7	0.8	-0.3
Chronic bronchitis/emphysema (mother)	0.3	0.3	0.4	-0.6	0.5
Medication: Omeprazole	0.3	0.4	0.8	0.1	-0.9
Comparative height size at age 10	0.3	1.4	2.0	-1.4	-0.9
Illnesses of father: Heart disease	0.3	0.4	0.7	0.8	0.4
Smoking status: Previous	0.3	0.4	0.8	-0.9	0.1
Osteoporosis (self-reported)	0.3	0.4	0.7	0.8	-0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.3	0.5	0.6	-0.7	0.7
Wears glasses or contact lenses	0.3	0.3	0.6	-0.8	-0.1
Hearing aid user	0.3	0.3	0.3	0.6	0.6
Medication: Paracetamol	0.3	0.4	0.7	-0.8	-0.3
Ever smoked	0.3	0.6	1.1	-0.2	-1.1
Heart attack/myocardial infarction (self-reported)	0.3	0.4	0.8	-0.9	-0.1
Arm predicted mass (left)	0.3	1.4	2.0	1.4	-0.9
Breast Cancer	0.2	0.5	1.0	-1.0	0.1
Ovarian Cancer	0.2	0.2	0.3	-0.5	-0.4
Primary Biliary Cirrhosis	0.2	0.2	0.4	0.4	0.6
Schizophrenia (2014)	0.2	0.4	0.4	0.6	-0.7
Blood Eosinophil Count	0.2	1.5	2.9	-1.7	-0.2
BMI	0.2	1.1	1.9	-0.5	-1.4
Respiratory disease	0.2	0.4	0.7	0.8	0.3
Lung FVC	0.2	1.0	2.0	-1.4	0.2
Average weekly spirits intake	0.2	0.3	0.3	-0.5	-0.6
Impedance of leg (right)	0.2	0.8	1.1	1.1	0.7
Townsend deprivation index at recruitment	0.2	0.3	0.5	-0.7	-0.3
Taking other prescription medications	0.2	0.3	0.6	0.8	-0.2
Bilateral oophorectomy (both ovaries removed)	0.2	0.2	0.5	-0.7	-0.0
Leg predicted mass (left)	0.2	0.9	1.5	-1.2	-0.6
Falls in the last year	0.2	0.3	0.5	0.3	0.7
Forced expiratory volume in 1-second (FEV1)	0.2	0.8	1.6	-0.2	1.3
Lung cancer (father)	0.2	0.2	0.4	0.7	0.2
Tense / ‘highly strung’	0.2	0.3	0.5	0.7	-0.1
Peak expiratory flow (PEF)	0.2	0.4	0.6	0.4	-0.8
Ever highly irritable/argumentative for 2 days	0.2	0.2	0.3	0.6	0.3
Loud music exposure frequency	0.2	0.2	0.5	0.2	-0.7
Heart disease (mother)	0.2	0.2	0.5	-0.1	-0.7
Alcohol intake frequency.	0.2	0.4	0.6	0.5	0.7
Leg fat-free mass (right)	0.2	1.1	1.8	-1.3	-0.6
Mood swings	0.2	0.4	0.7	0.9	-0.2
Ever had stillbirth, spontaneous miscarriage or termination	0.2	0.2	0.2	0.4	-0.4
Leg predicted mass (right)	0.2	1.3	2.0	-1.4	-0.7
Arm fat-free mass (left)	0.2	1.2	1.7	1.3	-0.8
Irritability	0.2	0.4	0.8	0.9	-0.1
Alcohol drinker status: Previous	0.2	0.2	0.4	-0.3	0.6
Schizophrenia (2018)	0.1	0.3	0.6	0.1	-0.8
Bipolar Disorder (2011)	0.1	0.1	0.1	-0.1	-0.3
Mean Putamen Volume	0.1	0.2	0.3	-0.6	0.1
Fasting Glucose	0.1	0.1	0.1	-0.4	0.3
Tanning	0.1	0.9	1.5	-0.5	1.2
Hearing difficulty/problems: Yes	0.1	0.1	0.1	-0.4	-0.4
Supplements: Zinc	0.1	0.1	0.1	-0.1	0.4
Diabetes (mother)	0.1	0.2	0.3	0.6	0.0
Leg fat-free mass (left)	0.1	0.8	1.3	-1.1	-0.5
Diverticular disease/diverticulitis (self-reported)	0.1	0.1	0.2	-0.5	-0.1
Happiness	0.1	0.1	0.1	0.3	-0.3
Noisy workplace	0.1	0.1	0.2	0.4	-0.1
Asthma	0.1	0.1	0.2	0.3	-0.4
Standing height	0.1	0.8	1.1	-1.0	0.7
Medication: Ventolin 100micrograms inhaler	0.1	0.1	0.2	0.1	0.5
Comparative body size at age 10	0.1	0.2	0.3	-0.1	0.6
Health satisfaction	0.1	0.2	0.2	0.5	-0.3
Shortness of breath walking on level ground	0.1	0.2	0.3	0.6	0.1
Suffer from ‘nerves’	0.1	0.1	0.3	0.1	-0.5
Whole body fat-free mass	0.1	0.5	0.7	0.8	-0.5
Osteoarthritis (self-reported)	0.1	0.2	0.2	-0.4	-0.5
Whole body water mass	0.1	0.5	0.8	0.9	-0.5
Average weekly champagne plus white wine intake	0.1	0.1	0.3	-0.1	0.5
Miserableness	0.1	0.1	0.2	-0.4	-0.2
Mother’s age at death	0.1	0.1	0.2	-0.2	0.4
Basal cell carcinoma (self-reported)	0.1	0.1	0.2	-0.4	0.3
Pack years of smoking	0.1	0.2	0.2	0.5	0.3
Bipolar Disorder or Schizophrenia	0.0	0.0	0.0	0.0	0.0
Blood Platelet Count	0.0	0.4	0.6	0.3	0.8
Blood White Count	0.0	0.3	0.6	-0.1	0.8
Impedance of leg (left)	0.0	0.2	0.3	0.6	0.2
Hair/balding pattern: Pattern 2	0.0	0.0	0.0	0.1	0.1
Medication: Ramipril	0.0	0.0	0.0	0.2	-0.0
Depression (self-reported)	0.0	0.0	0.1	-0.3	0.1
Seen doctor (GP) for nerves, anxiety, tension or depression	0.0	0.0	0.0	0.0	0.1
Birth weight of first child	0.0	0.0	0.0	-0.1	-0.1
Mouth/teeth dental problems: Bleeding gums	0.0	0.0	0.1	0.1	-0.3
Medication: Paracetamol	0.0	0.1	0.1	0.3	0.2
Pulse rate, automated reading	0.0	0.1	0.2	0.4	-0.1
Knee pain experienced in last month	0.0	0.0	0.1	-0.3	-0.0
Mineral and other dietary supplements	0.0	0.0	0.1	0.3	0.0
Breast cancer (self-reported)	0.0	0.0	0.0	0.1	0.1
Asthma (self-reported)	0.0	0.1	0.2	0.1	-0.4
Basal metabolic rate	0.0	0.3	0.5	0.2	-0.7

Hub : Genes

C22orf31

Models

Trait associations