Hub : Genes

ZNRF3

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Artery Aorta	0.1670	0.0550	2.3e-05	0.169	NA	0.131	NA	0.173	1.3e-09	NA	1.1e-07	NA	8.1e-10
2	GTEx	Artery Tibial	0.0786	0.0325	2.0e-03	0.015	NA	-0.001	NA	0.001	2.1e-02	NA	3.7e-01	NA	2.9e-01
3	GTEx	Lung	0.0838	0.0347	3.8e-03	-0.003	NA	0.021	NA	0.001	6.2e-01	NA	8.6e-03	NA	2.6e-01
4	TCGA	Brain Lower Grade Glioma	0.0845	0.0398	3.0e-03	0.021	-0.002	0.021	NA	0.008	1.7e-03	0.87	1.6e-03	NA	3.9e-02
5	TCGA	Skin Cutaneous Melanoma	0.4380	0.1460	2.5e-03	-0.011	0.048	0.012	NA	-0.010	9.5e-01	0.02	1.5e-01	NA	7.8e-01

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bipolar Disorder (2018)	0.3	0.4	0.7	-0.1	-0.4	-0.7	-0.9	0.9
Bipolar Disorder or Schizophrenia	1.3	3.3	5.3	-2.3	-2.1	-0.9	-2.0	-1.4
Depressed Affect (Nagel 2018)	0.4	0.8	2.9	-0.4	0.1	0.7	-0.6	-1.7
Depression (Nagel 2018)	2.8	4.2	16.3	-1.1	-0.7	0.6	-1.6	-4.0
Intelligence (Savage-Jansen 2018)	0.8	2.6	4.0	1.8	1.2	2.0	1.2	1.6
Neuroticism (Nagel 2018)	1.4	3.2	9.7	-1.7	-1.0	0.7	-1.4	-3.1
Schizophrenia (2018)	2.2	4.5	8.1	-2.8	-2.4	-0.5	-1.7	-2.4
Schizophrenia vs Biploar Disorder	0.9	1.2	4.0	-0.8	-0.4	0.6	0.9	-2.0
Worry (Nagel 2018)	1.2	2.4	5.4	-2.3	-1.5	0.2	-0.7	-2.0
Alzheimer’s Disease (in mother)	0.7	0.8	1.4	-1.2	-0.9	-1.0	0.7	0.4
Alzheimer’s Disease (in father)	0.4	0.4	1.5	-0.1	-0.3	-0.3	-1.2	-0.6
Alzheimer’s Disease (including proxy)	0.6	0.9	2.5	-0.9	-0.6	-1.6	0.1	0.9
Crohns Disease (2017)	1.3	2.9	7.0	1.6	2.0	-2.6	0.7	0.8
Irritable Bowel Disease (IBD)	1.5	3.5	9.5	1.8	2.0	-3.1	-0.3	1.0
Ulcerative Colitis (UC)	1.0	1.8	4.3	1.3	1.1	-2.1	-1.0	1.0
Major Depression (MDD)	0.6	0.8	2.6	-1.0	-0.3	-1.6	-0.2	0.3
Reaction Time	0.6	1.1	3.7	0.2	0.9	0.2	-0.8	1.9
Verbal and Numeric Reasoning (VNR)	0.8	1.9	4.5	2.1	1.6	0.6	-0.1	1.4
Breast Cancer	4.0	9.7	16.5	4.1	2.6	0.6	3.9	3.1
Ovarian Cancer	0.3	0.4	1.1	-0.8	0.2	-1.1	-0.2	-0.4
Prostate Cancer	1.2	1.7	5.2	0.6	1.2	-2.3	-0.4	-1.0
Age at First Birth	0.6	0.8	1.8	1.1	0.7	-0.4	0.6	1.3
Bipolar Disorder (2011)	0.3	0.3	1.2	0.2	0.1	-0.0	-1.1	-0.5
Body Mass Index (BMI) (2010)	0.9	1.2	2.8	1.1	1.3	-1.7	0.4	0.3
Coronary Artery Disease (CAD)	1.2	1.4	3.2	1.8	0.9	1.2	0.7	-1.2
Crohns Disease (2012)	1.2	1.9	4.7	1.4	2.2	-1.5	0.4	0.5
Mean Putamen Volume	0.7	0.7	1.4	-1.2	-1.0	-0.3	1.1	0.2
Fasting Glucose	0.2	0.2	0.9	0.1	-0.9	0.0	-0.5	0.2
HbA1C	0.7	0.8	2.4	0.1	0.4	-1.5	-1.2	0.0
HDL Cholesterol	1.5	2.5	6.9	-2.3	-2.6	-0.0	-0.2	0.3
LDL Cholesterol	0.1	0.1	0.4	-0.0	0.0	-0.5	0.1	-0.6
Lupus	0.6	0.9	3.8	0.6	0.4	0.2	-1.9	-0.4
Neuroticism (2016)	3.5	5.1	9.7	-3.1	-2.5	0.4	-1.3	-2.8
Primary Biliary Cirrhosis	0.5	0.7	1.2	-0.9	-1.1	0.9	-0.7	-0.1
Rheumatoid Arthritis	1.3	1.8	6.7	0.9	1.0	0.2	-0.7	2.6
Schizophrenia (2014)	3.3	7.2	14.2	-3.8	-3.2	-0.6	-1.6	-2.9
Triglycerides	0.6	1.1	2.8	1.5	1.7	0.2	0.2	-0.1
Type 2 Diabetes (T2D) (2012)	1.1	1.3	4.0	-0.8	-0.8	0.7	-0.7	-2.0
Ulcerative Colitis	1.2	1.8	6.9	0.4	0.8	-2.6	-1.1	-0.3
Blood Eosinophil Count	0.4	2.7	7.7	-2.8	-1.9	-1.2	-1.0	-0.2
Blood Platelet Count	0.4	5.1	13.4	-2.9	-1.8	-3.7	-0.9	0.1
Blood Red Count	1.0	10.1	24.4	3.4	4.9	-2.9	-0.1	2.5
Blood White Count	0.2	1.8	8.0	-0.7	-0.2	-0.8	-2.8	0.1
Heel T-Score	9.0	71.9	196.0	9.1	7.5	-2.9	-4.1	14.0
BMI	0.1	0.6	1.6	1.3	0.9	0.5	-0.1	-0.5
Height	0.2	3.7	11.8	0.4	-2.0	-1.1	1.1	3.4
Waist Hip Ratio (WHR)	3.8	17.0	42.5	-0.1	2.5	-1.9	-5.7	-6.5
Systolic Blood Pressure	3.8	18.8	51.5	-3.6	-3.2	1.1	-4.3	-7.2
Smoking Status	2.0	4.7	9.0	-2.9	-3.0	0.7	-0.1	-2.4
Allergy or Eczema	2.4	6.3	16.2	-2.7	-1.3	-4.0	-2.5	0.1
Cardiovascular Disease	3.9	12.9	47.4	-2.0	-2.2	1.3	-2.5	-6.9
Hypothyroidism (self reported)	0.8	1.9	6.4	-0.1	0.2	-1.5	0.8	2.5
Respiratory disease	0.3	0.8	2.6	-1.6	-0.6	-0.5	0.7	-0.1
Type 2 Diabetes (T2D) (2018)	1.3	2.4	4.4	-1.1	-1.4	1.9	0.8	-2.1
Lung FEV1/FVC ratio	0.7	3.4	7.8	2.8	2.5	0.3	-0.1	1.6
Lung FVC	0.5	2.5	4.5	-1.9	-2.1	-1.0	-1.8	-0.5
Neuroticism	0.8	1.8	4.9	-1.4	-0.5	1.3	-0.6	-2.2
Chronotype (morning person)	0.3	0.6	1.2	-0.9	-0.4	1.1	0.9	0.2
Hair Pigment	0.2	6.4	25.8	-1.9	0.3	0.4	-1.5	-5.1
Tanning	0.2	2.7	6.2	-1.1	-0.6	-2.5	1.4	1.8
Hand grip strength (left)	0.2	0.4	1.1	0.6	0.4	-1.0	-0.7	0.2
Number of treatments/medications taken	5.2	9.4	17.8	-3.8	-2.9	0.1	-2.4	-4.2
Average weekly spirits intake	0.5	0.6	2.0	-0.3	-0.6	0.1	-0.6	-1.4
Sensitivity / hurt feelings	3.0	5.1	9.3	-2.7	-2.3	0.5	-1.8	-3.1
Frequency of depressed mood in last 2 weeks	2.6	3.6	12.4	-0.9	-0.4	-0.6	-2.1	-3.5
Hearing difficulty/problems: Yes	2.6	4.0	8.0	-2.2	-2.1	-0.2	-2.8	-1.6
Relative age of first facial hair	3.2	6.7	17.3	-4.2	-3.5	1.0	-1.3	-1.1
Other serious medical condition/disability diagnosed by doctor	1.3	1.7	5.7	-0.1	-0.3	1.5	-0.8	-2.4
Ever used hormone-replacement therapy (HRT)	3.0	3.9	6.0	-2.0	-1.7	2.4	1.4	-2.1
Ever had hysterectomy (womb removed)	0.3	0.4	1.1	-1.1	-0.8	-0.2	-0.2	-0.3
Systolic blood pressure, automated reading	3.3	9.6	22.8	-3.2	-2.8	0.9	-2.6	-4.8
Eye problems/disorders: Diabetes related eye disease	2.0	2.2	2.9	-1.7	-1.7	1.2	-1.2	-1.6
Angina	1.1	1.5	2.5	-1.6	-0.9	0.2	-1.4	-1.4
Medication for hormone replacement therapy	2.2	2.4	4.8	-1.5	-1.1	1.8	-0.7	-2.2
Vitamin and mineral supplements	1.6	2.2	5.4	1.0	1.0	-1.8	0.0	2.3
Supplements: Zinc	0.3	0.3	1.3	0.2	0.4	-1.1	-0.3	0.4
Medication: Co-codamol	1.6	1.8	5.9	-1.4	-1.0	-0.1	0.7	-2.4
Medication: Metformin	1.8	2.6	6.6	-1.1	-1.5	1.4	0.8	-2.6
Diabetes (father)	2.0	2.4	5.7	2.4	1.9	1.6	0.7	0.0
Diabetes (mother)	0.7	0.9	2.7	1.6	1.0	-0.7	-0.4	-0.3
Severe depression (siblings)	1.6	1.8	3.2	-1.8	-1.5	-1.2	1.5	0.1
Pack years adult smoking proportion	0.9	1.4	2.1	-1.2	-1.4	1.4	-0.5	-1.2
Impedance of leg (right)	0.5	2.4	6.1	-2.5	-2.1	0.8	0.9	-0.1
Leg fat-free mass (left)	0.2	0.9	2.9	1.7	0.6	-0.7	-0.6	0.4
Trunk fat percentage	0.3	1.0	2.7	-0.8	-1.6	1.2	0.2	0.3
Hand grip strength (right)	0.4	1.1	3.7	-0.1	-0.4	-0.8	-1.9	-1.1
Townsend deprivation index at recruitment	2.4	3.3	7.7	-2.8	-2.3	-0.1	-1.1	-1.6
Current tobacco smoking	3.2	5.2	9.3	-2.6	-3.1	0.7	-0.3	-3.0
Average weekly fortified wine intake	0.3	0.3	0.9	-0.2	-0.2	0.4	-0.9	-0.7
Maternal smoking around birth	3.7	5.3	9.9	-2.9	-3.1	2.0	0.0	-2.2
Fed-up feelings	0.2	0.4	0.9	0.0	0.2	-0.9	-0.4	-1.0
Frequency of unenthusiasm / disinterest in last 2 weeks	3.1	4.1	10.2	-1.5	-1.2	0.5	-2.5	-3.2
Relative age voice broke	1.4	2.2	5.1	-2.3	-2.1	1.1	-0.1	0.3
Taking other prescription medications	8.1	12.5	22.3	-4.7	-4.3	0.3	-2.8	-3.7
Age when periods started (menarche)	0.8	1.9	5.4	1.5	1.4	0.4	-0.5	2.3
Bilateral oophorectomy (both ovaries removed)	5.5	6.4	9.8	-3.1	-3.1	1.8	-2.0	-2.3
Heel bone mineral density (BMD) T-score, automated (left)	7.8	17.7	53.3	4.0	3.3	-2.4	-1.4	7.3
Tinnitus: Yes, but not now, but have in the past	2.4	2.6	12.5	-0.4	0.0	-3.5	-0.6	0.0
Qualifications: CSEs or equivalent	0.7	1.0	2.7	0.3	0.6	-1.6	-1.3	-0.2
Serious illness, injury or assault to yourself	1.4	1.7	4.6	-2.1	-1.3	-0.6	0.1	-1.2
High blood pressure	5.8	16.1	50.8	-3.2	-3.4	2.5	-1.3	-7.1
Hayfever, allergic rhinitis or eczema	1.5	3.3	11.7	-1.7	-0.4	-3.4	-1.4	-0.1
Multivitamins +/- minerals	0.8	1.0	2.8	-0.3	-0.6	1.3	-0.2	-1.7
Stomach or abdominal pain in last month	0.8	1.0	2.2	-1.3	-0.8	-1.5	-0.5	0.0
Supplements: Glucosamine	1.0	1.3	5.9	-0.1	-0.0	-0.3	2.4	0.6
Diverticular disease/diverticulitis (self-reported)	0.9	1.1	2.9	0.9	0.4	1.3	-1.7	0.0
Medication: Atenolol	2.7	3.4	8.3	-2.2	-1.9	0.2	-0.5	-2.9
Medication: Levothyroxine sodium	0.6	1.0	3.0	-0.7	-0.4	-1.7	-0.1	1.1
Sitting height	0.9	6.1	18.2	2.6	1.1	-2.0	-0.5	4.3
Chronic bronchitis/emphysema (father)	1.0	1.2	2.7	-0.1	0.5	-0.9	1.4	1.6
High blood pressure (mother)	0.7	1.0	2.3	-0.0	-0.2	0.8	-1.5	-1.5
Body mass index (BMI)	0.1	0.5	0.7	0.7	0.5	0.8	-0.4	-0.9
Impedance of leg (left)	0.6	3.0	7.7	-2.8	-2.3	0.9	0.8	-0.5
Leg predicted mass (left)	0.2	0.9	3.3	1.8	0.7	-0.6	-0.5	0.4
Trunk fat mass	0.1	0.3	0.9	-0.0	-0.9	0.7	0.0	0.3
Waist circumference	0.3	1.1	3.7	0.2	0.5	-0.6	-1.0	-1.9
Number of incorrect matches in round	0.9	1.5	3.5	-1.1	-0.8	-1.9	0.5	-1.4
Past tobacco smoking	1.5	2.8	6.8	2.6	2.2	-0.8	-0.8	1.0
Alcohol usually taken with meals	4.5	7.2	18.7	4.3	3.4	-0.5	0.0	2.4
Nervous feelings	3.9	7.2	12.1	-3.5	-2.8	0.5	-2.7	-2.8
Frequency of tenseness / restlessness in last 2 weeks	3.5	5.5	12.5	-2.9	-2.2	0.9	-0.7	-3.5
Hearing difficulty/problems with background noise	2.2	3.4	6.7	-2.6	-2.5	-0.2	-0.5	-2.0
Hair/balding pattern: Pattern 2	1.4	1.7	3.2	1.5	1.2	1.0	1.8	0.8
Had menopause	1.0	1.2	3.3	1.2	0.6	1.8	0.9	0.4
Had other major operations	1.1	1.3	4.5	-0.8	-0.5	0.5	-1.0	-2.1
Forced vital capacity (FVC)	0.5	1.9	3.8	-1.0	-1.6	-2.0	-0.2	1.5
Heel bone mineral density (BMD) T-score, automated (right)	8.1	18.5	50.9	4.5	3.9	-2.2	-1.2	7.1
Ever unenthusiastic/disinterested for a whole week	1.7	2.1	4.0	-1.7	-1.4	-0.6	-1.1	-2.0
Qualifications: None of the above	1.6	3.5	7.6	-2.8	-2.1	1.4	0.1	-1.8
Financial difficulties in last 2 years	2.8	3.7	11.8	-0.1	0.2	-3.4	-1.6	-2.0
Mouth/teeth dental problems	0.2	0.4	0.9	0.9	0.7	0.4	0.3	0.3
Heart attack	0.7	0.9	1.9	1.2	1.0	1.4	-0.6	-0.1
Allergy	1.4	3.2	11.7	1.9	0.4	3.4	0.9	0.1
Pain all over the body in last month	1.4	1.5	3.5	-1.0	-1.2	0.9	-0.7	-1.9
Diabetes (self-reported)	1.3	2.1	5.3	-1.0	-0.9	1.0	1.5	-2.3
Hayfever/allergic rhinitis (self-reported)	2.0	2.6	6.1	-2.1	-1.3	-2.5	0.4	1.0
Medication: Ramipril	0.2	0.3	1.1	-0.1	-0.3	0.4	-0.5	-1.0
Medication: Simvastatin	0.5	0.7	2.5	0.3	-0.2	0.9	-0.3	-1.6
Fluid intelligence score	2.5	5.3	11.5	2.8	2.5	-0.8	0.7	3.4
Illnesses of siblings	0.8	1.1	3.0	0.8	0.8	0.0	-1.1	1.7
Neuroticism score	1.0	2.1	6.2	-1.6	-0.9	0.3	-0.9	-2.5
Weight	0.0	0.2	1.1	1.0	0.1	0.3	0.1	0.2
Impedance of arm (right)	1.2	5.5	10.5	-2.4	-3.1	0.8	1.0	3.2
Arm fat percentage (right)	0.2	0.7	2.6	0.2	-0.4	1.6	0.4	0.8
Trunk fat-free mass	0.5	3.0	8.3	2.9	2.4	-1.1	-0.1	0.1
Hip circumference	0.4	1.8	3.0	-0.8	-1.7	1.0	1.6	1.2
Time employed in main current job	0.2	0.2	0.5	-0.1	-0.2	-0.7	-0.5	0.3
Alcohol intake versus 10 years previously	0.7	1.0	3.3	-0.8	-0.4	1.8	-0.2	-0.9
Father’s age at death	0.8	1.0	1.7	1.3	0.8	-1.0	-1.3	0.3
Worrier / anxious feelings	1.3	2.4	4.4	-1.8	-1.3	-1.2	-1.1	-2.1
Frequency of tiredness / lethargy in last 2 weeks	4.1	6.7	11.6	-2.8	-2.4	1.0	-2.7	-3.4
Falls in the last year	0.3	0.4	1.1	-1.0	-0.6	-0.3	-0.6	-0.2
Hair/balding pattern: Pattern 3	0.8	1.3	3.4	-1.0	-1.8	-0.6	0.8	0.9
Number of live births	1.0	1.5	3.7	-0.4	-0.2	-1.9	1.5	-1.1
Forced expiratory volume in 1-second (FEV1)	0.3	1.0	2.1	-0.2	-1.0	-1.3	-0.3	1.4
Pulse rate	1.0	1.6	3.7	-1.2	-1.4	0.9	0.6	-1.9
Happiness	0.7	0.8	1.5	-0.9	-1.2	-0.1	-1.0	-1.0
Noisy workplace	1.2	1.4	3.5	-1.9	-1.3	-0.2	-0.6	-1.3
Qualifications: A levels/AS levels or equivalent	3.4	7.6	13.6	3.7	2.8	-1.8	-1.2	3.4
Serious illness, injury or assault of a close relative in last 2 years	0.3	0.4	1.7	-0.2	-0.0	-0.2	-0.3	-1.3
Mouth/teeth dental problems: Dentures	1.4	2.3	6.1	1.0	1.4	-2.5	-1.2	1.1
Asthma	0.6	1.2	3.3	-1.8	-0.8	0.1	1.2	-0.7
Medication: Ibuprofen (e.g. Nurofen)	1.0	1.3	2.5	-1.6	-1.3	-1.3	0.1	0.7
Medication: Cholesterol lowering	0.4	0.6	1.5	1.1	1.2	-0.6	-0.2	0.1
Depression (self-reported)	1.5	1.7	3.7	-1.9	-1.7	-0.5	-0.9	-1.1
Medication: Lansoprazole	0.8	0.9	1.8	-1.1	-1.3	-0.7	0.8	-0.2
Prospective memory result	1.8	2.2	3.8	-1.7	-1.9	1.2	-0.6	-1.5
Lung cancer (father)	0.6	0.7	1.4	-1.2	-1.2	0.0	0.7	-0.7
Illnesses of mother	0.9	1.1	2.6	0.8	0.9	-1.0	1.6	0.6
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	1.1	2.0	-0.5	-1.3	-1.1	-0.3	1.4
Pulse wave Arterial Stiffness index	0.4	0.4	1.2	0.1	0.4	1.1	-0.3	-0.8
Impedance of arm (left)	1.1	5.2	12.7	-2.5	-3.6	0.6	0.4	2.6
Arm fat mass (right)	0.1	0.3	0.9	0.7	0.0	0.9	0.2	0.2
Trunk predicted mass	0.5	3.1	8.5	2.9	2.5	-1.0	-0.1	0.1
Standing height	0.1	1.4	3.6	0.8	-0.8	-1.2	0.8	1.9
Length of working week for main job	1.3	1.4	3.1	1.7	1.0	0.1	-0.0	1.8
Exposure to tobacco smoke at home	0.1	0.1	0.3	0.0	-0.5	0.2	0.1	0.1
Breastfed as a baby	0.3	0.4	1.0	0.3	0.4	1.0	0.7	-0.3
Tense / ‘highly strung’	1.9	3.1	5.9	-2.4	-2.4	0.8	-0.9	-1.5
Seen doctor (GP) for nerves, anxiety, tension or depression	2.7	4.1	6.9	-2.6	-1.8	-0.1	-2.4	-2.1
Hair/balding pattern: Pattern 4	5.1	12.4	25.1	-3.5	-5.0	2.6	-2.5	-3.4
Birth weight of first child	0.2	0.3	0.5	0.4	0.7	0.1	0.7	0.6
Peak expiratory flow (PEF)	0.2	0.5	1.3	1.1	0.2	0.8	0.9	-0.1
Pulse wave reflection index	1.9	2.3	4.5	1.8	2.1	-0.2	-2.0	-0.3
Ever highly irritable/argumentative for 2 days	0.5	0.6	1.6	-0.2	-0.2	1.3	-0.3	-1.1
Loud music exposure frequency	3.4	3.7	7.9	-2.8	-2.7	-0.1	-1.0	-1.5
Qualifications: O levels/GCSEs or equivalent	1.3	2.1	5.9	0.8	-0.0	-2.4	-0.2	2.0
Mouth/teeth dental problems: Bleeding gums	3.1	4.0	9.5	-3.1	-2.8	0.3	-0.0	-1.6
Blood clot in the leg (DVT)	1.0	1.3	5.7	0.1	0.5	-2.4	-0.4	0.8
Medication: Paracetamol	2.2	3.6	6.7	-2.3	-1.6	-1.6	-2.6	-1.1
Headache pain in last month	1.6	2.7	5.1	-1.9	-1.6	-2.3	-1.5	-0.3
Medication for cholesterol, blood pressure or diabetes	0.5	0.8	3.1	-0.1	-0.3	0.2	0.8	1.7
Glaucoma (self-reported)	1.9	2.2	10.1	-0.5	-0.1	-0.9	0.2	-3.2
Gout (self-reported)	0.1	0.1	0.3	0.1	-0.0	-0.5	0.5	-0.4
Hypothyroidism/myxoedema (self-reported)	0.5	0.9	1.6	-0.9	-0.7	-1.3	-0.4	1.2
Medication: Amlodipine	2.4	3.4	9.2	-1.7	-1.6	1.0	-1.3	-3.0
Medication: Ventolin 100micrograms inhaler	0.5	0.6	2.0	-0.9	0.3	-0.2	-1.4	-0.4
Birth weight	3.0	6.4	21.5	1.2	1.5	-2.6	0.3	4.6
Chronic bronchitis/emphysema (mother)	1.1	1.3	2.5	-1.4	-1.6	-1.2	0.8	-0.1
High blood pressure (siblings)	1.8	2.6	4.4	-2.1	-1.9	-0.2	-0.8	-2.1
Forced vital capacity (FVC), Best measure	0.5	1.8	3.7	-1.2	-1.9	-1.2	-0.1	1.5
Body fat percentage	0.2	0.9	1.9	-0.7	-1.4	1.4	0.0	-0.1
Leg fat percentage (right)	0.3	1.1	3.3	-0.5	-0.4	1.8	0.3	-1.3
Arm fat-free mass (right)	0.4	2.1	5.0	2.2	1.7	-1.1	-0.6	-1.2
Exposure to tobacco smoke outside home	0.4	0.5	1.0	-1.0	-0.9	0.1	-0.9	-0.1
Comparative body size at age 10	0.7	1.9	7.1	0.7	0.4	-1.4	-2.7	0.2
Number of full brothers	0.6	0.8	1.2	1.1	0.9	0.2	0.8	-1.1
Worry too long after embarrassment	2.1	3.6	6.2	-2.1	-1.9	0.7	-1.7	-2.5
Seen a psychiatrist for nerves, anxiety, tension or depression	0.6	0.7	1.3	0.9	1.1	0.1	-0.5	1.1
Wheeze or whistling in the chest in last year	1.8	3.1	6.7	-2.6	-1.7	-0.6	-0.9	-2.2
Number of children fathered	0.4	0.4	1.9	-0.0	-0.1	0.4	-0.3	-1.4
Reason for reducing amount of alcohol drunk: Health precaution	0.7	0.9	3.3	-0.6	-0.8	-0.2	1.8	-0.1
Age at first live birth	4.3	7.6	14.1	3.8	3.1	-1.7	0.9	3.3
Pulse wave peak to peak time	0.6	0.6	1.5	0.1	-0.3	-1.2	0.4	1.2
Health satisfaction	2.9	3.7	8.0	-2.8	-2.5	1.1	-0.4	-1.8
Shortness of breath walking on level ground	1.1	1.4	2.6	-0.9	-0.8	-0.1	-1.6	-1.6
Qualifications: College or University degree	1.4	4.5	9.6	3.1	2.8	0.6	-0.2	2.1
Eye problems/disorders: None of the above	1.3	1.4	3.1	0.9	1.3	0.6	1.1	1.7
Mouth/teeth dental problems: Loose teeth	0.9	1.1	2.7	-0.0	-0.0	1.6	0.7	-1.4
Emphysema/chronic bronchitis	0.8	1.0	4.2	-0.1	0.3	-2.0	-0.5	-0.4
Medication for pain relief, constipation, heartburn	1.7	3.0	4.9	2.1	1.3	0.4	1.9	2.2
Neck or shoulder pain in last month	0.2	0.3	0.9	-0.4	-0.2	-0.8	0.9	-0.1
Medication: Blood pressure	1.1	2.0	8.6	-0.3	-0.2	0.3	-1.1	-2.9
Angina (self-reported)	0.7	0.9	1.7	-1.2	-0.5	0.4	-1.0	-1.3
Migraine (self-reported)	1.5	1.9	3.5	-1.9	-1.5	-1.7	-0.8	-0.1
Medication: Ibuprofen	1.5	1.7	3.4	-1.8	-1.3	-1.6	-1.0	0.3
Medication: Allopurinol	0.8	1.1	3.5	-0.7	-0.5	-0.7	0.9	-1.9
Medication: Omeprazole	2.0	2.3	4.2	-1.5	-1.5	1.2	2.0	-1.2
Medication: Seretide 50 evohaler	0.3	0.3	1.2	0.5	0.3	-1.1	0.2	0.2
Mean time to correctly identify matches	0.3	0.6	1.8	0.1	0.8	0.6	-0.4	1.3
Heart disease (mother)	1.1	1.3	4.0	-0.7	-0.6	0.3	-2.0	-1.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.1	1.4	4.5	-0.6	-0.7	1.0	0.5	-2.1
Whole body fat mass	0.1	0.2	0.6	-0.0	-0.8	0.8	-0.1	-0.1
Leg fat mass (right)	0.1	0.6	1.4	0.1	-0.3	1.2	-0.2	-1.1
Arm predicted mass (right)	0.4	2.1	5.1	2.3	1.7	-1.0	-0.6	-1.1
Pulse rate, automated reading	0.1	0.2	0.4	0.6	0.6	-0.2	-0.0	-0.5
Alcohol intake frequency.	0.2	0.6	2.5	0.1	0.4	-0.2	-1.6	0.3
Comparative height size at age 10	0.2	0.9	2.6	-0.9	-1.6	-0.0	0.9	-0.4
Number of full sisters	1.7	2.1	4.0	-1.6	-2.0	0.2	1.9	0.0
Suffer from ‘nerves’	1.5	2.3	4.1	-2.0	-1.4	0.9	-1.6	-1.5
Overall health rating	3.0	6.4	12.7	-3.0	-2.6	0.6	-1.9	-3.6
Chest pain or discomfort	0.3	0.4	1.6	-0.5	0.4	-0.2	-1.3	-0.2
Had major operations	0.8	1.0	2.0	1.4	1.4	0.5	-0.8	0.1
Age at last live birth	4.9	7.1	13.0	3.6	2.9	-1.9	1.6	2.8
Family relationship satisfaction	1.4	1.7	5.6	-1.3	-1.2	-0.1	0.1	-2.4
Leg pain on walking	0.8	1.0	3.9	-0.3	-0.1	2.0	-0.9	-0.5
Qualifications: NVQ or HND or HNC or equivalent	1.6	1.9	6.8	1.1	1.0	-0.5	2.6	0.5
Commuting to job workplace: Car/motor vehicle	0.2	0.2	0.7	0.3	0.4	-0.8	0.5	-0.2
Illness, injury, bereavement, stress in last 2 years	1.4	1.7	3.8	0.5	0.3	1.6	1.3	2.0
Medication: Aspirin	1.0	1.3	3.3	0.7	1.0	0.8	-1.0	-1.8
Supplements: Vitamin C	0.3	0.3	0.7	-0.3	-0.8	0.8	0.1	-0.6
Knee pain experienced in last month	0.2	0.4	0.8	-0.5	-0.6	-0.7	0.9	0.1
Hypertension (Self-reported)	5.6	15.6	48.1	-3.3	-3.4	2.0	-1.8	-6.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.8	0.9	2.5	-0.7	-0.8	-0.7	1.6	-0.6
Illnesses of father: Heart disease	1.0	1.4	2.9	1.4	1.3	0.6	-1.7	-0.1
Illnesses of siblings: Diabetes	0.8	1.0	1.5	1.1	1.0	-1.2	1.2	-0.3
Smoking status: Previous	0.2	0.3	0.7	-0.9	-0.5	-0.1	0.5	0.4
Forced expiratory volume in 1-second (FEV1), predicted	0.6	1.3	3.4	0.5	-0.3	-1.8	-0.4	1.6
Whole body fat-free mass	0.4	2.1	6.3	2.5	1.8	-0.9	-0.3	-0.0
Leg fat-free mass (right)	0.2	1.0	3.5	1.9	0.8	-0.7	-0.4	0.4
Arm fat percentage (left)	0.1	0.5	2.0	0.2	-0.4	1.4	-0.0	0.4
Average weekly red wine intake	1.5	2.2	3.9	2.0	1.8	-0.1	-1.6	1.1
Handedness (chirality/laterality): Left-handed	1.2	1.5	5.1	0.9	0.9	-2.3	-0.1	0.7
Mood swings	0.2	0.3	1.1	-0.0	0.5	0.2	-0.0	-1.1
Loneliness, isolation	1.5	2.1	4.9	-0.8	-0.6	0.2	-2.1	-2.2
Long-standing illness, disability or infirmity	3.2	4.9	12.3	-2.3	-1.5	0.7	-2.1	-3.5
Ever had bowel cancer screening	2.2	2.6	5.9	1.2	1.0	2.4	2.2	-0.2
Diabetes diagnosed by doctor	1.5	2.4	5.0	-0.3	-0.3	1.8	1.9	-2.2
Ever had stillbirth, spontaneous miscarriage or termination	0.4	0.4	0.8	0.3	0.4	0.9	0.7	-0.7
Friendships satisfaction	0.7	0.9	1.7	-1.1	-0.9	0.4	-0.5	-1.3
Qualifications: nursing, teaching	0.6	0.9	1.8	1.0	1.3	-1.2	-0.5	0.4
Commuting to job workplace: Walk	0.3	0.3	0.8	-0.9	-0.0	-0.6	0.4	0.2
Eye problems/disorders: Cataract	0.4	0.4	0.8	-0.7	-0.9	-0.4	-0.4	-0.7
Mouth/teeth dental problems: Mouth ulcers	0.7	1.2	2.2	-0.9	-1.0	1.5	1.3	-0.2
Medication for cholesterol	4.2	6.3	17.5	2.3	2.2	-1.9	0.9	4.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.0	1.2	4.3	0.6	0.7	2.1	-0.4	-0.7
Back pain experienced in last month	0.5	0.7	1.8	-1.3	-0.8	-0.6	-0.9	-0.1
Mineral and other dietary supplements	0.1	0.2	0.3	0.0	-0.5	-0.5	-0.6	0.2
Breast cancer (self-reported)	0.6	0.8	1.3	-1.1	-1.1	-0.2	-1.0	-0.6
Asthma (self-reported)	0.7	1.5	3.9	-2.0	-1.1	0.4	1.3	-0.7
Osteoporosis (self-reported)	1.1	1.4	4.3	-1.3	-0.6	2.1	0.8	-0.2
Osteoarthritis (self-reported)	0.5	0.7	1.6	-1.0	-0.6	0.4	1.2	-0.5
Medication: Aspirin	1.0	1.3	2.9	0.6	0.9	0.8	-1.3	-1.7
Medication: Gliclazide	2.0	2.3	8.0	0.8	0.8	1.2	2.8	-0.7
Illnesses of father: None of the above (group 1)	0.4	0.4	0.8	-0.8	-0.9	0.1	0.9	0.2
Smoking status: Current	3.1	4.9	9.1	-2.6	-3.0	1.0	-0.2	-2.8
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.3	0.7	2.0	-1.0	-1.4	-0.2	-0.4	0.4
Whole body water mass	0.4	2.1	6.3	2.5	1.8	-1.0	-0.4	-0.0
Leg predicted mass (right)	0.2	1.0	3.4	1.9	0.7	-0.7	-0.4	0.4
Arm fat mass (left)	0.1	0.3	0.7	0.8	0.1	0.9	-0.1	0.3
Number of self-reported non-cancer illnesses	4.8	8.4	19.8	-3.5	-2.9	1.0	-0.3	-4.4
Average weekly champagne plus white wine intake	0.5	0.7	3.0	0.4	-0.1	-0.4	0.4	1.7
Miserableness	1.3	2.3	4.0	-2.0	-1.6	1.0	-1.2	-1.5
Guilty feelings	2.3	3.5	11.8	-1.6	-1.1	-0.2	-1.3	-3.4
Wears glasses or contact lenses	0.2	0.2	0.4	-0.2	-0.3	0.2	0.7	0.5
Ever taken oral contraceptive pill	2.6	2.9	11.5	0.9	1.0	-0.6	3.4	0.9
Hearing aid user	1.0	1.2	2.3	1.0	1.0	0.9	-1.5	0.8
Mother’s age at death	0.5	0.7	1.1	0.7	1.0	-0.3	-0.8	1.0
Financial situation satisfaction	1.3	1.6	4.1	-0.4	-0.8	-1.1	-2.0	-1.3
Tinnitus: Yes, now most or all of the time	0.6	0.7	1.4	-0.3	-0.6	-0.8	-1.2	0.9
Commuting to job workplace: Public transport	1.3	1.6	3.3	1.2	1.1	0.1	-1.8	1.4
Eye problems/disorders: Glaucoma	1.8	2.1	9.5	0.1	0.4	-1.0	-0.2	-3.1
Medication: Blood pressure	6.0	11.4	24.8	-3.7	-3.9	1.8	-0.7	-5.0
Pain type(s) experienced in last month: Hip pain	2.8	3.5	7.6	-0.6	-0.5	2.8	2.3	-2.1
Supplements: Fish oil (including cod liver oil)	0.3	0.4	1.5	-0.3	-0.3	1.2	0.4	-0.6
High cholesterol (Self-reported)	0.2	0.4	1.5	0.3	0.4	0.1	1.2	-0.7
Medication: Bendroflumethiazide	3.0	4.5	12.3	-1.8	-2.3	0.1	-1.5	-3.5
Medication: Paracetamol	2.6	4.0	7.9	-2.8	-2.6	-0.7	-1.9	-1.1
Medication: Lisinopril	0.6	0.8	2.0	0.3	0.4	-0.8	-1.4	-1.1
Medication: Atorvastatin	0.7	0.9	2.5	-0.6	0.6	0.6	-0.8	-1.6
Illnesses of father: High blood pressure	1.2	1.5	4.2	-1.1	-1.0	-0.6	-0.8	-2.1
Alcohol drinker status: Never	1.7	2.0	6.4	1.0	1.6	-0.1	-2.5	0.0
Ever smoked	2.1	3.7	8.2	-2.9	-2.5	0.5	0.9	-1.7
Basal metabolic rate	0.2	1.3	4.5	2.1	1.3	-0.6	-0.2	-0.0
Leg fat percentage (left)	0.4	1.5	3.9	-0.8	-0.7	2.0	0.2	-1.6
Arm fat-free mass (left)	0.4	1.8	4.9	2.2	1.8	-0.8	-0.1	-0.5
Number of operations (self-reported)	0.6	0.9	3.0	0.9	0.9	1.7	-0.3	-0.4
Average weekly beer plus cider intake	1.4	2.0	5.6	-1.5	-1.2	0.3	2.4	-0.9
Irritability	1.3	2.1	4.4	1.7	2.1	1.7	-0.3	-0.6
Risk taking	0.5	0.7	1.9	0.9	0.6	-0.6	1.4	-0.2
Ever had prostate specific antigen (PSA) test	1.3	1.5	4.3	1.5	2.1	0.8	-0.6	0.3
Fractured/broken bones in last 5 years	2.2	2.8	5.6	-2.4	-1.6	-1.9	0.6	-1.3
Age started oral contraceptive pill	0.4	0.5	1.6	-0.2	-0.2	-0.8	0.2	1.3
Diastolic blood pressure, automated reading	1.5	4.5	15.4	-1.9	-1.3	-0.0	-1.3	-3.9
Ever depressed for a whole week	1.6	2.0	3.7	-1.9	-1.6	0.1	-0.2	-1.9
Unable to work because of sickness or disability	1.2	1.5	3.5	-1.5	-1.1	0.6	-0.6	-1.9
Commuting to job workplace: Cycle	0.8	1.0	2.0	0.7	1.4	-0.5	0.8	1.2
Myopia	2.1	3.1	6.5	-1.2	-1.2	2.2	1.1	-2.5
Vascular/heart problems diagnosed by doctor	4.7	12.9	40.6	2.5	2.7	-2.7	1.6	6.4
Cholesterol lowering medication	1.4	2.0	5.2	-0.8	-1.0	1.7	-0.6	-2.3
Medication: Omeprazole (e.g. Zanprol)	2.2	2.6	7.2	-0.9	-1.0	1.7	2.7	-1.0
Pain experienced in last month	1.8	2.9	7.4	2.7	2.4	0.7	-0.0	0.9
Supplements: Calcium	0.8	0.8	2.0	-1.1	-0.8	0.5	-1.4	-0.3
Basal cell carcinoma (self-reported)	2.7	3.3	8.3	-1.6	-1.9	-0.9	-2.9	-1.1
Heart attack/myocardial infarction (self-reported)	0.6	0.7	1.5	0.8	0.8	1.2	-0.9	-0.2
Deep venous thrombosis (DVT) (self-reported)	1.6	2.0	8.0	0.2	0.7	-2.8	-0.1	1.2
Heart disease (siblings)	0.5	0.6	0.9	-0.6	-0.6	-0.8	0.9	-0.9
Alcohol drinker status: Previous	0.6	0.6	1.3	-0.5	-0.8	0.5	1.1	0.9
Pack years of smoking	1.2	1.8	3.2	-1.4	-1.6	1.8	-0.2	-1.1
Impedance of whole body	0.9	4.5	10.9	-2.8	-3.3	0.7	0.9	1.6
Leg fat mass (left)	0.2	0.7	1.8	-0.2	-0.5	1.2	-0.4	-1.3
Arm predicted mass (left)	0.4	1.9	5.4	2.3	1.8	-0.8	-0.1	-0.6