TWAS
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Usage
Models
Genes
Traits
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Traits
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Cardiovascular Disease
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chr2:24,021,231-26,068,509
Best TWAS P=7.09e-11 · Best GWAS P=1.62e-08 conditioned to 0.189
24M
24.5M
25M
25.5M
26M
0
2
4
6
8
physical position
-log10 P
Conditional
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
1
GTEx
Adipose Visceral Omentum
NCOA1
0.11
0.02
enet
17
0.02
2.1e-02
-4.7
-6.5
7.1e-11
0.73
0.03
0.85
TRUE
2
ROSMAP
Brain Pre-frontal Cortex
EFR3B
0.07
0.03
bslmm
348
0.03
3.5e-05
4.3
-5.8
8.5e-09
0.34
0.13
0.49
FALSE
3
The Cancer Genome Atlas
Glioblastoma Multiforme
ADCY3
0.36
0.14
enet
7
0.13
8.9e-05
-5.6
5.7
1.3e-08
-0.91
0.00
0.95
FALSE
4
The Cancer Genome Atlas
Prostate Adenocarcinoma
ADCY3
0.09
0.02
enet
11
0.04
3.2e-05
-5.6
5.6
1.9e-08
-0.79
0.00
0.99
FALSE