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chr3:135,273,949-138,894,063

Best TWAS P=3.09e-14 · Best GWAS P=1.83e-18 conditioned to 7.7e-06

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
3	GTEx	Artery Aorta	PCCB	0.12	0.03	enet	11	0.09	2.0e-05	-8.6	7.6	3.1e-14	-0.82	0.07	0.90	TRUE
10	GTEx	Brain Frontal Cortex BA9	DBR1	0.18	0.10	lasso	5	0.11	9.7e-04	6.1	6.3	3.2e-10	0.00	0.03	0.86	TRUE
21	ROSMAP	Brain Pre-frontal Cortex	PCCB	0.10	0.07	lasso	4	0.10	4.2e-13	4.5	7.5	5.2e-14	-0.78	0.06	0.94	FALSE
8	GTEx	Brain Cerebellar Hemisphere	RP11-731C17.2	0.16	0.02	enet	24	0.09	3.0e-03	-7.2	7.1	1.8e-12	-0.82	0.08	0.67	FALSE
9	GTEx	Brain Frontal Cortex BA9	PCCB	0.11	0.01	enet	9	0.01	1.7e-01	-5.7	6.9	4.7e-12	-0.72	0.06	0.52	FALSE
18	GTEx	Thyroid	PCCB	0.10	0.09	lasso	6	0.09	1.3e-07	4.7	6.7	1.5e-11	-0.71	0.31	0.68	FALSE
28	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	PCCB	0.07	0.06	blup	53	0.06	2.1e-04	3.5	6.6	3.9e-11	-0.68	0.12	0.58	FALSE
33	The Cancer Genome Atlas	Testicular Germ Cell Tumors	PCCB	0.13	0.02	blup	53	0.02	4.4e-02	1.9	6.6	4.4e-11	-0.73	0.02	0.38	FALSE
19	GTEx	Thyroid	RP11-85F14.5	0.07	0.00	lasso	7	0.01	4.7e-02	-5.4	6.6	4.8e-11	-0.69	0.07	0.53	FALSE
27	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	PCCB	0.05	0.05	blup	54	0.05	3.5e-06	4.4	6.3	3.0e-10	-0.64	0.72	0.27	FALSE
24	The Cancer Genome Atlas	Breast Invasive Carcinoma	MSL2	0.05	0.01	enet	6	0.01	1.5e-03	2.1	6.3	3.4e-10	-0.69	0.01	0.90	FALSE
20	METSIM	Adipose	PCCB	0.07	0.06	lasso	12	0.06	4.1e-09	4.3	6.2	4.5e-10	-0.65	0.96	0.04	FALSE
6	GTEx	Artery Tibial	PCCB	0.05	0.02	lasso	5	0.02	1.7e-02	4.4	6.1	9.9e-10	-0.60	0.34	0.56	FALSE
29	The Cancer Genome Atlas	Brain Lower Grade Glioma	MRAS	0.03	0.01	blup	49	0.01	9.6e-03	5.2	-6.1	1.2e-09	-0.03	0.04	0.71	FALSE
23	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	PCCB	0.05	0.03	blup	53	0.03	1.2e-03	4.4	6.1	1.3e-09	-0.63	0.15	0.21	FALSE
30	The Cancer Genome Atlas	Brain Lower Grade Glioma	PCCB	0.06	0.05	lasso	2	0.03	1.2e-04	4.5	6.1	1.3e-09	-0.59	0.22	0.72	FALSE
7	GTEx	Artery Tibial	MRAS	0.24	0.20	enet	7	0.20	2.3e-15	6.1	6.0	1.5e-09	0.01	0.02	0.98	FALSE
11	GTEx	Brain Hippocampus	RP11-731C17.2	0.19	0.06	enet	24	0.11	1.8e-03	-2.5	6.0	1.6e-09	-0.72	0.09	0.69	FALSE
4	GTEx	Artery Aorta	MRAS	0.52	0.53	lasso	5	0.54	2.5e-34	6.1	6.0	2.0e-09	-0.01	0.02	0.98	FALSE
5	GTEx	Artery Coronary	MRAS	0.32	0.10	lasso	4	0.12	7.4e-05	6.1	6.0	2.7e-09	-0.01	0.02	0.96	FALSE
32	The Cancer Genome Atlas	Soft Tissue Sarcoma	MRAS	0.04	0.03	blup	49	0.04	1.8e-03	5.1	5.9	3.0e-09	0.03	0.06	0.55	FALSE
15	GTEx	Muscle Skeletal	PCCB	0.09	0.09	enet	13	0.11	1.2e-10	3.5	5.8	6.1e-09	-0.57	1.00	0.00	FALSE
17	GTEx	Testis	MRAS	0.20	0.14	lasso	4	0.11	1.2e-05	5.2	-5.8	6.4e-09	-0.03	0.08	0.88	FALSE
31	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	PCCB	0.12	0.07	enet	3	0.06	1.0e-04	4.6	5.7	9.5e-09	-0.60	0.23	0.46	FALSE
25	The Cancer Genome Atlas	Breast Invasive Carcinoma	PCCB	0.05	0.02	enet	12	0.04	4.0e-09	3.6	5.7	1.1e-08	-0.58	0.32	0.68	FALSE
16	GTEx	Testis	PCCB	0.26	0.22	lasso	10	0.22	4.7e-10	4.4	5.7	1.2e-08	-0.58	0.99	0.01	FALSE
2	GTEx	Adipose Subcutaneous	PCCB	0.07	0.05	enet	4	0.02	6.6e-03	-5.8	5.6	2.8e-08	-0.55	0.36	0.15	FALSE
14	GTEx	Lung	RP11-85F14.5	0.07	0.05	lasso	19	0.05	8.8e-05	-5.4	5.5	4.5e-08	-0.67	0.93	0.03	FALSE
1	CommonMind	Brain Pre-frontal Cortex	ESYT3	0.04	0.01	blup	314	0.04	2.4e-05	4.2	5.5	4.9e-08	0.03	0.29	0.62	FALSE
13	GTEx	Esophagus Mucosa	RP11-85F14.5	0.13	0.10	lasso	3	0.11	5.1e-08	-5.4	5.5	5.0e-08	-0.65	0.99	0.01	FALSE
22	YFS	Blood	NCK1	0.01	0.02	enet	4	0.02	2.2e-06	-5.4	5.4	5.6e-08	-0.65	0.91	0.08	FALSE
26	The Cancer Genome Atlas	Breast Invasive Carcinoma	TMEM22	0.03	0.01	enet	9	0.01	4.0e-03	-5.4	5.4	7.0e-08	-0.61	0.07	0.53	FALSE
12	GTEx	Breast Mammary Tissue	PCCB	0.08	0.05	lasso	3	0.03	1.3e-02	-5.8	5.2	1.5e-07	-0.53	0.20	0.34	FALSE