[Hub]/) : Traits : Cardiovascular Disease :

chr7:73,425,238-75,714,883

Best TWAS P=2.06e-10 · Best GWAS P=1.3e-08 conditioned to 0.971

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex PMS2P5 0.29 0.05 enet 20 0.14 7.3e-17 4.6 -5.1 2.9e-07 -0.50 0.61 0.38 FALSE
2 GTEx Adipose Subcutaneous STAG3L2 0.16 0.03 enet 11 0.09 1.0e-07 4.6 -5.5 2.9e-08 -0.71 0.11 0.87 FALSE
3 GTEx Adipose Subcutaneous AC004166.6 0.09 0.08 lasso 2 0.07 3.9e-06 5.3 5.3 9.6e-08 0.85 0.04 0.95 FALSE
4 GTEx Adipose Subcutaneous STAG3L1 0.30 0.24 enet 24 0.27 2.4e-22 -4.6 -5.3 9.2e-08 -0.12 0.00 0.97 TRUE
5 GTEx Adrenal Gland STAG3L2 0.14 0.07 enet 3 0.11 1.2e-04 5.1 -5.6 2.5e-08 -0.92 0.03 0.71 FALSE
6 GTEx Artery Coronary PMS2P5 0.15 -0.01 enet 13 0.08 1.4e-03 4.6 -5.5 3.5e-08 -0.68 0.01 0.72 FALSE
7 GTEx Artery Coronary STAG3L2 0.16 0.10 lasso 3 0.11 1.5e-04 4.6 -5.3 1.0e-07 -0.83 0.03 0.84 FALSE
8 GTEx Artery Tibial PMS2P5 0.21 0.08 lasso 5 0.07 1.9e-06 4.6 -5.7 1.4e-08 -0.70 0.08 0.86 FALSE
9 GTEx Brain Cerebellum PMS2P5 0.62 0.08 lasso 6 0.22 3.3e-07 4.6 -5.5 4.7e-08 -0.71 0.02 0.85 FALSE
10 GTEx Brain Frontal Cortex BA9 STAG3L2 0.28 0.07 lasso 4 0.11 9.7e-04 5.3 -5.2 1.5e-07 -0.86 0.02 0.60 FALSE
11 GTEx Brain Hippocampus PMS2P5 0.37 0.03 enet 12 0.05 2.9e-02 5.7 -5.4 5.8e-08 -0.87 0.01 0.63 FALSE
12 GTEx Brain Nucleus accumbens basal ganglia PMS2P5 0.27 0.00 enet 20 0.03 6.6e-02 4.6 -5.6 2.3e-08 -0.64 0.02 0.38 FALSE
13 GTEx Breast Mammary Tissue STAG3L2 0.14 0.08 lasso 2 0.11 4.0e-06 4.6 -5.3 8.6e-08 -0.84 0.17 0.77 FALSE
14 GTEx Cells EBV-transformed lymphocytes PMS2P5 0.16 0.06 lasso 3 0.04 1.7e-02 5.3 -5.6 2.3e-08 -0.82 0.01 0.75 FALSE
15 GTEx Cells Transformed fibroblasts PMS2P5 0.31 0.16 lasso 5 0.18 2.1e-13 4.6 -5.7 1.4e-08 -0.80 0.42 0.58 FALSE
16 GTEx Esophagus Gastroesophageal Junction PMS2P5 0.23 0.19 lasso 2 0.18 5.4e-07 5.3 -5.8 6.5e-09 -0.77 0.02 0.96 FALSE
17 GTEx Esophagus Mucosa PMS2P5 0.14 0.03 lasso 4 0.04 1.7e-03 5.3 -6.4 2.1e-10 -0.79 0.02 0.76 TRUE
18 GTEx Esophagus Muscularis STAG3L2 0.23 0.09 enet 33 0.15 1.9e-09 4.6 -5.5 3.4e-08 -0.76 0.03 0.97 FALSE
19 GTEx Heart Atrial Appendage PMS2P5 0.12 0.03 lasso 5 0.07 3.8e-04 5.3 -5.9 3.6e-09 -0.75 0.02 0.38 FALSE
20 GTEx Lung STAG3L2 0.13 0.11 enet 11 0.09 1.4e-07 4.6 -5.9 3.6e-09 -0.77 0.29 0.70 FALSE
21 GTEx Nerve Tibial STAG3L2 0.36 0.09 enet 13 0.24 9.5e-17 4.6 -5.7 1.0e-08 -0.75 0.04 0.96 FALSE
22 GTEx Skin Sun Exposed Lower leg STAG3L2 0.15 0.05 enet 8 0.08 2.8e-07 4.6 -5.7 1.3e-08 -0.72 0.14 0.69 FALSE
23 GTEx Testis PMS2P5 0.22 0.13 lasso 2 0.13 3.1e-06 5.3 -5.1 3.0e-07 -0.75 0.03 0.86 FALSE
24 GTEx Testis STAG3L2 0.26 0.13 lasso 4 0.22 4.0e-10 3.6 -5.5 3.0e-08 -0.86 0.08 0.91 FALSE
25 GTEx Testis STAG3L1 0.24 0.24 enet 14 0.27 1.4e-12 -4.6 -5.2 2.5e-07 -0.12 0.00 0.97 FALSE
26 GTEx Thyroid GTF2IRD2B 0.03 0.04 lasso 1 0.03 1.9e-03 5.6 5.6 1.9e-08 0.96 0.01 0.85 FALSE
27 METSIM Adipose NCF1 0.05 0.03 blup 130 0.04 3.9e-07 5.7 5.5 2.8e-08 0.71 0.01 0.99 FALSE