[Hub]/) : Traits : Cardiovascular Disease : ← →

chr7:73,425,238-75,714,883

Best TWAS P=2.06e-10 · Best GWAS P=1.3e-08 conditioned to 0.971

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
17	GTEx	Esophagus Mucosa	PMS2P5	0.14	0.03	lasso	4	0.04	1.7e-03	5.3	-6.4	2.1e-10	-0.79	0.02	0.76	TRUE
4	GTEx	Adipose Subcutaneous	STAG3L1	0.30	0.24	enet	24	0.27	2.4e-22	-4.6	-5.3	9.2e-08	-0.12	0.00	0.97	TRUE
19	GTEx	Heart Atrial Appendage	PMS2P5	0.12	0.03	lasso	5	0.07	3.8e-04	5.3	-5.9	3.6e-09	-0.75	0.02	0.38	FALSE
20	GTEx	Lung	STAG3L2	0.13	0.11	enet	11	0.09	1.4e-07	4.6	-5.9	3.6e-09	-0.77	0.29	0.70	FALSE
16	GTEx	Esophagus Gastroesophageal Junction	PMS2P5	0.23	0.19	lasso	2	0.18	5.4e-07	5.3	-5.8	6.5e-09	-0.77	0.02	0.96	FALSE
21	GTEx	Nerve Tibial	STAG3L2	0.36	0.09	enet	13	0.24	9.5e-17	4.6	-5.7	1.0e-08	-0.75	0.04	0.96	FALSE
22	GTEx	Skin Sun Exposed Lower leg	STAG3L2	0.15	0.05	enet	8	0.08	2.8e-07	4.6	-5.7	1.3e-08	-0.72	0.14	0.69	FALSE
8	GTEx	Artery Tibial	PMS2P5	0.21	0.08	lasso	5	0.07	1.9e-06	4.6	-5.7	1.4e-08	-0.70	0.08	0.86	FALSE
15	GTEx	Cells Transformed fibroblasts	PMS2P5	0.31	0.16	lasso	5	0.18	2.1e-13	4.6	-5.7	1.4e-08	-0.80	0.42	0.58	FALSE
26	GTEx	Thyroid	GTF2IRD2B	0.03	0.04	lasso	1	0.03	1.9e-03	5.6	5.6	1.9e-08	0.96	0.01	0.85	FALSE
12	GTEx	Brain Nucleus accumbens basal ganglia	PMS2P5	0.27	0.00	enet	20	0.03	6.6e-02	4.6	-5.6	2.3e-08	-0.64	0.02	0.38	FALSE
14	GTEx	Cells EBV-transformed lymphocytes	PMS2P5	0.16	0.06	lasso	3	0.04	1.7e-02	5.3	-5.6	2.3e-08	-0.82	0.01	0.75	FALSE
5	GTEx	Adrenal Gland	STAG3L2	0.14	0.07	enet	3	0.11	1.2e-04	5.1	-5.6	2.5e-08	-0.92	0.03	0.71	FALSE
27	METSIM	Adipose	NCF1	0.05	0.03	blup	130	0.04	3.9e-07	5.7	5.5	2.8e-08	0.71	0.01	0.99	FALSE
2	GTEx	Adipose Subcutaneous	STAG3L2	0.16	0.03	enet	11	0.09	1.0e-07	4.6	-5.5	2.9e-08	-0.71	0.11	0.87	FALSE
24	GTEx	Testis	STAG3L2	0.26	0.13	lasso	4	0.22	4.0e-10	3.6	-5.5	3.0e-08	-0.86	0.08	0.91	FALSE
18	GTEx	Esophagus Muscularis	STAG3L2	0.23	0.09	enet	33	0.15	1.9e-09	4.6	-5.5	3.4e-08	-0.76	0.03	0.97	FALSE
6	GTEx	Artery Coronary	PMS2P5	0.15	-0.01	enet	13	0.08	1.4e-03	4.6	-5.5	3.5e-08	-0.68	0.01	0.72	FALSE
9	GTEx	Brain Cerebellum	PMS2P5	0.62	0.08	lasso	6	0.22	3.3e-07	4.6	-5.5	4.7e-08	-0.71	0.02	0.85	FALSE
11	GTEx	Brain Hippocampus	PMS2P5	0.37	0.03	enet	12	0.05	2.9e-02	5.7	-5.4	5.8e-08	-0.87	0.01	0.63	FALSE
13	GTEx	Breast Mammary Tissue	STAG3L2	0.14	0.08	lasso	2	0.11	4.0e-06	4.6	-5.3	8.6e-08	-0.84	0.17	0.77	FALSE
3	GTEx	Adipose Subcutaneous	AC004166.6	0.09	0.08	lasso	2	0.07	3.9e-06	5.3	5.3	9.6e-08	0.85	0.04	0.95	FALSE
7	GTEx	Artery Coronary	STAG3L2	0.16	0.10	lasso	3	0.11	1.5e-04	4.6	-5.3	1.0e-07	-0.83	0.03	0.84	FALSE
10	GTEx	Brain Frontal Cortex BA9	STAG3L2	0.28	0.07	lasso	4	0.11	9.7e-04	5.3	-5.2	1.5e-07	-0.86	0.02	0.60	FALSE
25	GTEx	Testis	STAG3L1	0.24	0.24	enet	14	0.27	1.4e-12	-4.6	-5.2	2.5e-07	-0.12	0.00	0.97	FALSE
1	CommonMind	Brain Pre-frontal Cortex	PMS2P5	0.29	0.05	enet	20	0.14	7.3e-17	4.6	-5.1	2.9e-07	-0.50	0.61	0.38	FALSE
23	GTEx	Testis	PMS2P5	0.22	0.13	lasso	2	0.13	3.1e-06	5.3	-5.1	3.0e-07	-0.75	0.03	0.86	FALSE