TWAS hub - GTF2IRD2B

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Adrenal Gland	0.386	0.113	0.0016	0.008	NA	0.119	NA	0.044	0.160	NA	4.8e-05	NA	0.0110
2	GTEx	Thyroid	0.025	0.016	0.0067	0.035	NA	0.023	NA	0.031	0.001	NA	6.2e-03	NA	0.0019

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Illnesses of mother	7.5	9.2	13.7	2.2	-3.7
Number of self-reported non-cancer illnesses	7.2	12.6	23.3	-1.4	4.8
Long-standing illness, disability or infirmity	6.9	10.5	16.2	-2.2	4.0
Taking other prescription medications	6.8	10.5	18.5	-1.6	4.3
Number of treatments/medications taken	6.6	11.9	23.6	-0.5	4.9
Age when periods started (menarche)	6.6	15.8	24.2	2.7	-4.9
Other serious medical condition/disability diagnosed by doctor	6.5	8.4	11.2	-2.4	3.3
Mouth/teeth dental problems	6.5	9.9	11.8	2.8	-3.4
Medication for cholesterol, blood pressure or diabetes	6.1	10.0	19.6	-0.7	-4.4
Hypertension (Self-reported)	6.1	16.8	31.6	-1.5	5.6
Diabetes (self-reported)	6.0	9.3	16.0	-1.6	4.0
Vascular/heart problems diagnosed by doctor	6.0	16.3	31.9	0.8	-5.7
High blood pressure	5.9	16.4	30.6	-1.5	5.5
Relative age voice broke	5.8	8.8	16.4	1.1	-4.1
Mouth/teeth dental problems: Dentures	5.7	9.7	14.6	-2.2	3.8
Overall health rating	5.7	12.3	22.6	-1.4	4.8
Medication: Blood pressure	5.6	9.8	19.2	0.6	4.4
Illnesses of siblings: Diabetes	5.6	6.8	10.6	-1.8	3.3
Irritable Bowel Disease (IBD)	5.4	12.9	15.1	3.3	-3.9
Heart disease (mother)	5.3	6.5	8.7	-2.1	2.9
Diabetes diagnosed by doctor	5.2	8.5	14.4	-1.6	3.8
Medication: Metformin	5.1	7.2	11.8	-1.6	3.4
Lupus	5.0	7.6	9.6	3.1	2.4
Cardiovascular Disease	5.0	16.4	31.6	-1.1	5.6
Medication: Amlodipine	5.0	7.0	13.7	-0.5	3.7
Supplements: Fish oil (including cod liver oil)	5.0	6.5	11.7	3.4	-1.1
Waist circumference	4.8	17.6	33.9	1.2	5.8
Type 2 Diabetes (T2D) (2018)	4.7	8.9	11.1	-2.6	3.3
Body mass index (BMI)	4.7	20.0	40.1	0.2	6.3
Alcohol intake frequency.	4.6	10.6	19.3	-1.4	4.4
Osteoarthritis (self-reported)	4.6	5.9	11.7	-0.4	3.4
Ulcerative Colitis (UC)	4.2	7.9	8.0	2.8	-2.8
BMI	4.2	24.6	49.1	0.1	7.0
Pack years adult smoking proportion	4.0	6.1	7.6	-2.1	2.8
Medication: Lisinopril	4.0	5.2	9.8	0.7	3.1
Crohns Disease (2017)	3.9	8.6	11.0	2.5	-3.3
Alcohol drinker status: Previous	3.9	4.4	6.1	-1.7	2.5
Pack years of smoking	3.9	5.7	6.8	-2.1	2.6
Impedance of leg (right)	3.8	18.6	34.0	1.8	-5.8
Diabetes (father)	3.7	4.6	6.8	-2.6	1.6
Happiness	3.7	4.5	4.7	-2.2	2.1
Headache pain in last month	3.7	6.4	7.0	-2.4	2.7
Age at last live birth	3.7	5.4	9.1	3.0	-1.3
Mean time to correctly identify matches	3.6	6.9	12.7	-1.1	3.6
Impedance of whole body	3.6	18.5	34.9	1.4	-5.9
Leg fat mass (left)	3.6	14.0	27.2	0.9	5.2
Arm fat percentage (right)	3.5	13.6	26.7	0.7	5.2
Illnesses of siblings	3.4	4.8	8.5	1.1	-2.9
Arm fat percentage (left)	3.4	13.6	27.0	0.4	5.2
Unable to work because of sickness or disability	3.4	4.5	8.8	0.4	3.0
Multivitamins +/- minerals	3.3	4.2	8.3	2.9	0.3
Arm fat mass (right)	3.3	13.5	26.2	0.9	5.1
Eye problems/disorders: Glaucoma	3.3	3.9	7.5	-2.7	0.6
Leg fat percentage (left)	3.3	11.8	23.1	0.7	4.8
Impedance of leg (left)	3.2	15.3	27.5	1.8	-5.2
Medication: Ramipril	3.2	4.1	8.1	-0.4	2.8
Medication: Cholesterol lowering	3.2	4.9	8.4	1.2	2.9
Leg fat mass (right)	3.2	12.5	24.2	0.9	4.9
Arm fat mass (left)	3.2	13.1	25.9	0.6	5.1
Commuting to job workplace: Cycle	3.2	3.9	5.4	-2.3	1.5
Lung FEV1/FVC ratio	3.1	15.5	16.1	-4.0	3.9
Mouth/teeth dental problems: Bleeding gums	3.1	4.0	5.5	-1.6	2.4
Medication: Blood pressure	3.1	6.0	10.7	-1.1	3.3
Medication: Atenolol	3.0	3.7	7.2	-0.5	2.7
High blood pressure (mother)	3.0	4.2	5.6	-2.4	1.7
Medication: Omeprazole	3.0	3.6	4.2	-2.0	1.8
Diastolic blood pressure, automated reading	3.0	9.2	16.6	-1.4	4.1
Breast Cancer	2.9	6.9	12.6	1.0	-3.6
High blood pressure (siblings)	2.9	4.2	5.8	-1.6	2.4
Medication: Simvastatin	2.8	4.1	7.7	0.7	2.8
Medication for cholesterol	2.8	4.2	7.2	1.1	-2.7
Medication: Bendroflumethiazide	2.8	4.2	7.1	-1.1	2.7
Mean Putamen Volume	2.7	3.1	4.0	1.5	-2.0
Whole body fat mass	2.7	11.2	21.3	1.1	4.6
Qualifications: None of the above	2.6	5.6	11.2	-0.1	3.3
Impedance of arm (right)	2.6	12.3	22.9	1.3	-4.8
Leg fat percentage (right)	2.6	9.4	18.2	0.7	4.3
Wheeze or whistling in the chest in last year	2.6	4.6	9.1	-0.4	3.0
Relative age of first facial hair	2.5	5.2	10.3	-0.0	-3.2
Heel bone mineral density (BMD) T-score, automated (right)	2.5	5.7	11.0	0.6	-3.3
Hip circumference	2.5	10.8	21.5	-0.2	4.6
Qualifications: A levels/AS levels or equivalent	2.5	5.6	11.0	0.5	-3.3
Impedance of arm (left)	2.5	11.7	23.2	0.5	-4.8
Medication: Paracetamol	2.5	4.1	8.2	-0.2	2.9
Body fat percentage	2.5	10.1	18.9	1.1	4.3
Average weekly champagne plus white wine intake	2.5	3.5	3.7	1.9	-1.8
Number of operations (self-reported)	2.5	3.7	7.4	-0.0	2.7
Intelligence (Savage-Jansen 2018)	2.4	7.2	13.3	1.1	-3.6
Systolic blood pressure, automated reading	2.4	7.0	9.5	-2.1	3.1
Age at first live birth	2.4	4.2	5.5	2.4	-1.7
Mineral and other dietary supplements	2.4	3.2	4.4	-2.1	1.4
Reaction Time	2.3	4.5	7.3	-1.3	2.7
Townsend deprivation index at recruitment	2.3	3.2	4.3	1.5	2.1
Ever highly irritable/argumentative for 2 days	2.3	2.7	5.3	-0.4	2.3
Qualifications: O levels/GCSEs or equivalent	2.3	3.6	6.2	1.1	-2.5
Medication for pain relief, constipation, heartburn	2.3	3.8	7.7	-0.1	-2.8
Medication: Omeprazole (e.g. Zanprol)	2.3	2.8	3.1	-1.8	1.6
Weight	2.2	10.6	20.2	1.1	4.5
Medication: Lansoprazole	2.2	2.5	4.8	0.4	2.2
Pulse rate, automated reading	2.2	7.0	13.2	0.8	3.6
Medication: Aspirin	2.2	2.9	4.6	1.1	2.1
Medication: Gliclazide	2.2	2.5	3.1	-1.8	1.3
Ever taken oral contraceptive pill	2.2	2.4	4.6	2.1	0.5
Alcohol drinker status: Never	2.2	2.7	5.4	-0.0	2.3
Cholesterol lowering medication	2.2	3.2	6.4	-0.1	2.5
Trunk fat mass	2.1	8.9	16.0	1.4	4.0
Smoking status: Current	2.1	3.3	5.0	2.2	1.3
Medication: Paracetamol	2.1	3.3	6.6	-0.2	2.6
Current tobacco smoking	2.0	3.3	4.5	2.1	1.4
Heel bone mineral density (BMD) T-score, automated (left)	2.0	4.6	8.2	1.0	-2.9
Stomach or abdominal pain in last month	2.0	2.5	3.1	-1.8	1.3
Diverticular disease/diverticulitis (self-reported)	2.0	2.4	4.0	-2.0	0.8
Forced expiratory volume in 1-second (FEV1), predicted	2.0	4.2	6.5	2.6	-1.4
Handedness (chirality/laterality): Left-handed	2.0	2.4	2.7	1.4	-1.6
Back pain experienced in last month	2.0	2.9	5.8	0.0	2.4
High cholesterol (Self-reported)	2.0	3.5	7.0	0.2	2.6
Ovarian Cancer	1.9	2.6	5.1	-0.0	-2.3
Primary Biliary Cirrhosis	1.9	2.7	5.2	0.4	-2.3
Vitamin and mineral supplements	1.9	2.6	3.1	-1.8	-1.4
Medication: Co-codamol	1.9	2.2	3.2	1.8	1.1
Frequency of tenseness / restlessness in last 2 weeks	1.9	2.9	5.2	-0.8	2.3
Allergy	1.9	4.3	8.4	0.3	-2.9
Number of full brothers	1.9	2.4	3.6	1.9	1.1
Medication: Aspirin	1.9	2.5	4.2	0.9	2.0
Mother’s age at death	1.9	2.4	4.4	0.7	-2.1
Prostate Cancer	1.8	2.6	5.1	0.2	-2.3
Severe depression (siblings)	1.8	2.0	2.1	1.5	1.4
Trunk fat percentage	1.8	7.2	12.9	1.3	3.6
Frequency of tiredness / lethargy in last 2 weeks	1.8	2.9	5.8	-0.1	2.4
Shortness of breath walking on level ground	1.8	2.2	4.3	0.2	2.1
Rheumatoid Arthritis	1.7	2.4	3.9	0.9	2.0
Supplements: Zinc	1.7	1.8	3.2	0.7	-1.8
Nervous feelings	1.7	3.2	5.4	-2.3	1.0
Father’s age at death	1.7	2.2	4.3	-0.4	-2.1
Lung cancer (father)	1.7	2.0	3.9	-0.0	2.0
Ever had hysterectomy (womb removed)	1.6	1.8	3.3	-0.6	1.8
Medication for hormone replacement therapy	1.6	1.7	3.5	-1.9	0.0
Chronic bronchitis/emphysema (mother)	1.6	1.9	3.4	0.6	1.9
Medication: Allopurinol	1.6	2.1	2.8	1.7	1.2
Schizophrenia (2018)	1.5	3.1	5.6	0.7	2.4
Body Mass Index (BMI) (2010)	1.5	2.0	4.1	0.1	2.0
Chest pain or discomfort	1.5	2.1	2.5	-1.6	1.3
Allergy or Eczema	1.4	3.6	7.1	-0.3	2.7
Fluid intelligence score	1.4	3.0	5.9	0.1	-2.4
LDL Cholesterol	1.3	2.1	2.9	-1.7	1.2
Maternal smoking around birth	1.3	1.8	2.8	1.0	1.7
Had menopause	1.3	1.6	3.2	-1.8	0.3
Heart attack	1.3	1.7	2.3	1.0	1.5
Medication: Seretide 50 evohaler	1.3	1.5	2.2	-0.9	1.5
Illnesses of father: Heart disease	1.3	1.8	3.6	1.9	0.1
HbA1C	1.2	1.3	2.6	0.2	-1.6
Neuroticism (2016)	1.2	1.7	1.9	1.2	-1.4
Ulcerative Colitis	1.2	1.7	3.4	0.2	-1.8
Alcohol usually taken with meals	1.2	1.9	2.6	1.1	-1.6
Pain all over the body in last month	1.2	1.3	2.6	1.6	0.2
Number of children fathered	1.2	1.3	2.7	1.6	-0.1
Medication: Atorvastatin	1.2	1.5	2.9	-0.2	1.7
Schizophrenia (2014)	1.1	2.4	3.3	1.2	1.8
Heel T-Score	1.1	9.1	16.2	1.4	-4.0
Sensitivity / hurt feelings	1.1	2.0	2.6	-1.2	-1.6
Diabetes (mother)	1.1	1.4	2.7	0.1	1.7
Leg predicted mass (left)	1.1	5.6	10.6	0.8	3.3
Pulse rate	1.1	1.9	2.9	1.7	1.0
Loud music exposure frequency	1.1	1.2	1.8	-0.8	1.3
Glaucoma (self-reported)	1.1	1.3	2.7	-1.6	0.0
Commuting to job workplace: Car/motor vehicle	1.1	1.3	2.3	0.5	-1.5
Leg fat-free mass (right)	1.1	5.8	11.2	0.6	3.4
Leg predicted mass (right)	1.1	5.9	11.4	0.7	3.4
Financial situation satisfaction	1.1	1.4	2.0	-0.8	1.4
Fractured/broken bones in last 5 years	1.1	1.4	2.1	0.8	-1.5
Alzheimer’s Disease (in mother)	1.0	1.2	2.4	0.1	-1.6
Alzheimer’s Disease (including proxy)	1.0	1.4	2.8	-0.3	-1.7
Systolic Blood Pressure	1.0	5.2	8.3	-1.5	2.9
Eye problems/disorders: Diabetes related eye disease	1.0	1.1	1.3	-1.0	1.1
Leg fat-free mass (left)	1.0	5.4	10.3	0.7	3.2
Number of incorrect matches in round	1.0	1.6	2.5	0.9	1.6
Asthma	1.0	2.0	3.5	0.7	1.9
Standing height	1.0	10.3	15.4	2.3	-3.9
Birth weight	1.0	2.1	2.4	1.3	-1.6
Health satisfaction	1.0	1.3	1.7	-0.9	1.3
Qualifications: nursing, teaching	1.0	1.6	3.1	-0.3	-1.8
Arm fat-free mass (left)	1.0	4.9	7.7	1.4	2.8
Ever had prostate specific antigen (PSA) test	1.0	1.1	2.0	1.4	0.4
Myopia	1.0	1.4	2.7	0.3	-1.6
Pain experienced in last month	1.0	1.7	3.3	-0.3	-1.8
Arm predicted mass (left)	1.0	5.2	8.5	1.4	2.9
Smoking Status	0.9	2.0	4.1	2.0	-0.1
Hayfever, allergic rhinitis or eczema	0.9	1.9	3.9	-0.1	2.0
Serious illness, injury or assault of a close relative in last 2 years	0.9	1.1	1.9	1.4	-0.5
Exposure to tobacco smoke outside home	0.9	1.2	2.4	-1.5	0.3
Family relationship satisfaction	0.9	1.1	1.7	-1.3	0.8
Leg pain on walking	0.9	1.1	2.2	-0.3	1.5
Asthma (self-reported)	0.9	1.7	3.0	0.6	1.7
Osteoporosis (self-reported)	0.9	1.1	1.4	-1.2	0.9
Basal metabolic rate	0.9	5.2	9.0	1.2	3.0
Heart attack/myocardial infarction (self-reported)	0.9	1.2	1.6	0.8	1.3
Deep venous thrombosis (DVT) (self-reported)	0.9	1.2	2.2	-1.5	0.4
Heart disease (siblings)	0.9	1.2	2.3	1.5	-0.1
Tinnitus: Yes, but not now, but have in the past	0.8	0.8	0.9	-0.9	0.9
Blood clot in the leg (DVT)	0.8	1.0	2.0	-1.4	0.1
Arm predicted mass (right)	0.8	4.1	7.6	0.8	2.8
Ever had stillbirth, spontaneous miscarriage or termination	0.8	0.9	1.8	1.3	-0.0
Basal cell carcinoma (self-reported)	0.8	0.9	1.9	0.0	1.4
Major Depression (MDD)	0.7	0.9	1.5	0.5	1.2
Verbal and Numeric Reasoning (VNR)	0.7	1.6	2.7	0.7	-1.6
Fasting Glucose	0.7	0.8	1.6	0.2	1.3
Lung FVC	0.7	3.4	3.6	-1.9	1.8
Qualifications: CSEs or equivalent	0.7	0.9	1.8	1.4	0.0
Number of live births	0.7	1.1	1.3	1.1	-0.9
Noisy workplace	0.7	0.9	1.6	-0.4	1.2
Birth weight of first child	0.7	1.3	2.5	-0.3	-1.6
Arm fat-free mass (right)	0.7	3.8	7.0	0.8	2.6
Qualifications: NVQ or HND or HNC or equivalent	0.7	0.8	1.3	1.2	-0.6
Supplements: Vitamin C	0.7	0.8	1.5	-0.1	1.2
Commuting to job workplace: Walk	0.7	0.8	1.5	-1.2	0.1
Whole body water mass	0.7	4.0	7.0	1.1	2.6
Triglycerides	0.6	1.0	2.0	0.1	1.4
Respiratory disease	0.6	1.3	1.7	1.0	1.3
Hand grip strength (left)	0.6	1.5	2.3	-0.8	-1.5
Ever used hormone-replacement therapy (HRT)	0.6	0.7	1.4	-1.2	0.2
Angina	0.6	0.7	1.5	-0.1	1.2
Serious illness, injury or assault to yourself	0.6	0.8	1.5	0.1	1.2
Sitting height	0.6	4.2	5.9	2.4	-1.6
Prospective memory result	0.6	0.7	1.4	0.2	-1.2
Seen doctor (GP) for nerves, anxiety, tension or depression	0.6	1.0	1.8	0.4	1.3
Angina (self-reported)	0.6	0.8	1.6	0.0	1.3
Number of full sisters	0.6	0.7	0.8	0.8	-0.9
Knee pain experienced in last month	0.6	0.9	1.6	-0.4	1.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.6	0.7	1.2	0.5	1.1
Whole body fat-free mass	0.6	3.4	5.9	1.0	2.4
Eye problems/disorders: Cataract	0.6	0.6	1.3	1.1	-0.1
Commuting to job workplace: Public transport	0.6	0.8	0.8	-0.8	0.9
Risk taking	0.6	0.9	1.3	1.1	-0.7
Age started oral contraceptive pill	0.6	0.7	0.9	0.7	1.0
Bipolar Disorder or Schizophrenia	0.5	1.3	1.8	0.9	1.4
Height	0.5	10.0	13.3	2.6	-3.6
Frequency of depressed mood in last 2 weeks	0.5	0.7	0.7	0.8	0.8
Average weekly fortified wine intake	0.5	0.6	1.0	-0.4	-1.0
Had other major operations	0.5	0.6	0.9	0.9	0.6
Length of working week for main job	0.5	0.5	1.0	-1.0	-0.1
Gout (self-reported)	0.5	0.7	1.0	0.7	1.0
Seen a psychiatrist for nerves, anxiety, tension or depression	0.5	0.6	0.9	0.6	0.9
Average weekly red wine intake	0.5	0.7	1.1	0.6	-1.0
Mood swings	0.5	0.8	1.6	0.2	-1.3
Hearing aid user	0.5	0.5	1.1	1.0	-0.1
Ever smoked	0.5	0.9	1.0	-1.0	0.8
Ever depressed for a whole week	0.5	0.6	0.6	-0.8	0.8
Frequency of unenthusiasm / disinterest in last 2 weeks	0.4	0.6	0.8	0.9	0.6
Hair/balding pattern: Pattern 3	0.4	0.6	0.6	-0.7	0.8
Exposure to tobacco smoke at home	0.4	0.5	0.8	0.9	0.4
Breastfed as a baby	0.4	0.5	0.7	-0.6	-0.8
Qualifications: College or University degree	0.4	1.1	2.2	-0.2	-1.5
Comparative height size at age 10	0.4	2.0	3.9	0.4	2.0
Mouth/teeth dental problems: Mouth ulcers	0.4	0.7	0.7	-0.8	-0.9
Depression (Nagel 2018)	0.3	0.5	1.0	0.3	1.0
Blood Red Count	0.3	2.4	4.9	-0.1	2.2
Waist Hip Ratio (WHR)	0.3	1.3	2.5	1.6	-0.3
Average weekly spirits intake	0.3	0.3	0.5	0.7	0.4
Supplements: Glucosamine	0.3	0.4	0.7	0.8	-0.4
Forced vital capacity (FVC)	0.3	1.3	1.8	0.9	-1.3
Trunk fat-free mass	0.3	1.8	2.7	1.0	1.6
Falls in the last year	0.3	0.4	0.9	-0.9	-0.0
Trunk predicted mass	0.3	2.0	2.8	1.1	1.7
Reason for reducing amount of alcohol drunk: Health precaution	0.3	0.3	0.6	-0.8	0.2
Mouth/teeth dental problems: Loose teeth	0.3	0.4	0.7	-0.8	0.3
Emphysema/chronic bronchitis	0.3	0.4	0.6	-0.3	0.8
Neck or shoulder pain in last month	0.3	0.5	0.8	0.3	0.9
Illness, injury, bereavement, stress in last 2 years	0.3	0.4	0.8	-0.9	0.0
Tinnitus: Yes, now most or all of the time	0.3	0.4	0.6	-0.3	0.8
Bipolar Disorder (2018)	0.2	0.3	0.7	0.1	-0.8
Worry (Nagel 2018)	0.2	0.5	1.0	-0.1	1.0
Blood Eosinophil Count	0.2	1.7	2.1	1.2	-1.4
Hearing difficulty/problems: Yes	0.2	0.4	0.5	0.7	0.5
Fed-up feelings	0.2	0.3	0.6	0.8	-0.2
Chronic bronchitis/emphysema (father)	0.2	0.2	0.3	-0.4	0.5
Hayfever/allergic rhinitis (self-reported)	0.2	0.2	0.4	0.3	0.6
Worrier / anxious feelings	0.2	0.3	0.5	-0.7	-0.4
Depression (self-reported)	0.2	0.2	0.3	0.4	0.5
Tense / ‘highly strung’	0.2	0.3	0.6	-0.8	0.3
Hair/balding pattern: Pattern 4	0.2	0.5	0.8	0.3	-0.9
Peak expiratory flow (PEF)	0.2	0.4	0.6	0.5	-0.8
Forced vital capacity (FVC), Best measure	0.2	0.8	1.5	0.2	-1.2
Migraine (self-reported)	0.2	0.3	0.5	-0.7	0.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.2	0.2	0.3	-0.6	-0.3
Had major operations	0.2	0.2	0.3	-0.3	0.5
Smoking status: Previous	0.2	0.4	0.5	-0.5	-0.7
Loneliness, isolation	0.2	0.2	0.3	-0.6	-0.4
Breast cancer (self-reported)	0.2	0.2	0.2	0.5	0.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.4	0.5	-0.5	0.7
Neuroticism (Nagel 2018)	0.1	0.1	0.2	-0.4	0.3
Alzheimer’s Disease (in father)	0.1	0.1	0.1	-0.3	-0.2
Age at First Birth	0.1	0.1	0.2	-0.1	-0.4
HDL Cholesterol	0.1	0.1	0.1	-0.3	0.3
Blood White Count	0.1	0.9	1.1	1.1	0.8
Neuroticism	0.1	0.1	0.3	0.5	-0.2
Chronotype (morning person)	0.1	0.2	0.2	0.4	0.4
Hair Pigment	0.1	2.6	4.7	-0.8	-2.2
Tanning	0.1	0.7	1.2	0.5	1.1
Hand grip strength (right)	0.1	0.3	0.5	-0.4	-0.7
Bilateral oophorectomy (both ovaries removed)	0.1	0.1	0.2	0.3	0.4
Medication: Levothyroxine sodium	0.1	0.2	0.4	-0.3	0.6
Past tobacco smoking	0.1	0.1	0.2	0.1	-0.5
Ever unenthusiastic/disinterested for a whole week	0.1	0.1	0.2	-0.5	-0.0
Financial difficulties in last 2 years	0.1	0.1	0.1	0.2	0.3
Time employed in main current job	0.1	0.1	0.2	-0.4	-0.3
Alcohol intake versus 10 years previously	0.1	0.1	0.2	0.2	0.4
Forced expiratory volume in 1-second (FEV1)	0.1	0.2	0.4	0.1	-0.6
Medication: Ibuprofen (e.g. Nurofen)	0.1	0.1	0.2	-0.1	-0.4
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.4	0.5	-0.7	-0.6
Pulse wave reflection index	0.1	0.1	0.2	-0.1	-0.4
Medication: Ventolin 100micrograms inhaler	0.1	0.1	0.3	-0.5	0.1
Worry too long after embarrassment	0.1	0.2	0.3	-0.5	0.4
Eye problems/disorders: None of the above	0.1	0.1	0.1	-0.3	-0.3
Medication: Ibuprofen	0.1	0.1	0.2	-0.4	-0.1
Suffer from ‘nerves’	0.1	0.2	0.4	-0.1	0.6
Friendships satisfaction	0.1	0.2	0.4	-0.6	-0.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.1	0.1	0.1	0.3	-0.1
Wears glasses or contact lenses	0.1	0.1	0.1	0.2	-0.3
Pain type(s) experienced in last month: Hip pain	0.1	0.1	0.3	0.5	0.1
Illnesses of father: High blood pressure	0.1	0.1	0.3	-0.5	-0.1
Average weekly beer plus cider intake	0.1	0.2	0.2	0.4	-0.5
Irritability	0.1	0.2	0.3	0.2	-0.5
Depressed Affect (Nagel 2018)	0.0	0.0	0.0	0.2	0.1
Schizophrenia vs Biploar Disorder	0.0	0.0	0.0	0.0	0.0
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0
Coronary Artery Disease (CAD)	0.0	0.0	0.0	0.0	0.0
Crohns Disease (2012)	0.0	0.0	0.0	0.0	0.0
Type 2 Diabetes (T2D) (2012)	0.0	0.0	0.0	0.0	0.0
Blood Platelet Count	0.0	0.3	0.3	-0.6	0.4
Hypothyroidism (self reported)	0.0	0.1	0.1	0.2	0.3
Hearing difficulty/problems with background noise	0.0	0.1	0.1	-0.2	-0.2
Hair/balding pattern: Pattern 2	0.0	0.0	0.1	0.1	0.3
Neuroticism score	0.0	0.0	0.1	0.1	-0.3
Pulse wave Arterial Stiffness index	0.0	0.0	0.0	-0.2	0.1
Hypothyroidism/myxoedema (self-reported)	0.0	0.1	0.1	0.3	0.2
Comparative body size at age 10	0.0	0.1	0.2	0.2	-0.4
Pulse wave peak to peak time	0.0	0.1	0.1	0.1	-0.3
Ever had bowel cancer screening	0.0	0.0	0.0	-0.1	0.0
Illnesses of father: None of the above (group 1)	0.0	0.0	0.1	0.0	-0.3
Miserableness	0.0	0.1	0.1	0.3	0.2
Guilty feelings	0.0	0.0	0.0	0.0	0.2
Supplements: Calcium	0.0	0.0	0.0	-0.2	-0.0

Hub : Genes

GTF2IRD2B

Models

Trait associations