Best TWAS P=2.34e-10 · Best GWAS P=6.93e-09 conditioned to 0.328
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Visceral Omentum | CCNE2 | 0.16 | 0.08 | enet | 20 | 0.06 | 5.8e-04 | 5.8 | -5.2 | 2.3e-07 | -0.89 | 0.01 | 0.99 | FALSE |
| 2 | GTEx | Artery Aorta | TP53INP1 | 0.08 | 0.02 | enet | 18 | 0.03 | 9.7e-03 | -5.1 | 5.2 | 2.1e-07 | 0.61 | 0.09 | 0.76 | FALSE |
| 3 | GTEx | Brain Cerebellum | NDUFAF6 | 0.28 | 0.13 | lasso | 7 | 0.14 | 5.8e-05 | 5.8 | -5.7 | 1.6e-08 | -0.95 | 0.01 | 0.99 | FALSE |
| 4 | GTEx | Cells Transformed fibroblasts | NDUFAF6 | 0.07 | 0.03 | enet | 9 | 0.01 | 7.6e-02 | 5.8 | -6.3 | 2.3e-10 | -0.83 | 0.01 | 0.97 | TRUE |
| 5 | GTEx | Heart Atrial Appendage | NDUFAF6 | 0.17 | 0.03 | lasso | 6 | 0.04 | 6.7e-03 | -4.6 | -5.7 | 1.5e-08 | -0.77 | 0.05 | 0.75 | FALSE |
| 6 | GTEx | Heart Left Ventricle | NDUFAF6 | 0.10 | 0.05 | lasso | 11 | 0.07 | 1.6e-04 | 4.6 | -5.2 | 1.5e-07 | -0.50 | 0.09 | 0.87 | FALSE |
| 7 | GTEx | Whole Blood | TP53INP1 | 0.07 | 0.04 | enet | 13 | 0.02 | 2.9e-03 | 5.8 | 5.6 | 2.1e-08 | 0.90 | 0.01 | 0.99 | FALSE |
| 8 | YFS | Blood | TP53INP1 | 0.03 | 0.02 | lasso | 5 | 0.02 | 8.0e-07 | 3.8 | 5.7 | 1.2e-08 | 0.82 | 0.04 | 0.96 | FALSE |
| 9 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | TP53INP1 | 0.04 | 0.05 | blup | 56 | 0.06 | 4.2e-07 | 5.8 | 5.9 | 4.1e-09 | 0.95 | 0.01 | 0.99 | FALSE |
| 10 | The Cancer Genome Atlas | Stomach Adenocarcinoma | TP53INP1 | 0.06 | 0.02 | lasso | 3 | 0.03 | 2.8e-03 | 5.8 | 5.8 | 8.0e-09 | 0.96 | 0.01 | 0.97 | FALSE |