Best TWAS P=1.14e-14 · Best GWAS P=3.33e-16 conditioned to 1.84e-11
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Artery Tibial | NSUN6 | 0.18 | 0.11 | lasso | 8 | 0.10 | 4.9e-08 | -3.5 | 5.8 | 4.9e-09 | -0.25 | 1.00 | 0.00 | FALSE |
| 2 | GTEx | Brain Cerebellar Hemisphere | RP11-499P20.2 | 0.38 | -0.01 | enet | 32 | 0.01 | 1.6e-01 | 1.5 | 5.4 | 5.6e-08 | -0.20 | 0.11 | 0.07 | FALSE |
| 3 | GTEx | Nerve Tibial | NSUN6 | 0.37 | 0.35 | enet | 36 | 0.36 | 1.7e-26 | -4.4 | 5.6 | 2.6e-08 | -0.12 | 1.00 | 0.00 | TRUE |
| 4 | GTEx | Whole Blood | NSUN6 | 0.06 | 0.04 | lasso | 2 | 0.04 | 2.4e-04 | -4.4 | 5.2 | 2.3e-07 | -0.19 | 0.62 | 0.02 | FALSE |
| 5 | The Cancer Genome Atlas | Brain Lower Grade Glioma | CACNB2 | 0.05 | 0.05 | enet | 4 | 0.04 | 8.8e-06 | 6.7 | 7.7 | 1.1e-14 | -0.11 | 0.26 | 0.73 | TRUE |