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chr4:47,444,186-55,394,323

Best TWAS P=1.05e-35 · Best GWAS P=1.33e-36 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	SGCB	0.02	0.02	enet	21	0.01	9.7e-03	6.8	5.4	8.1e-08	0.37	0.04	0.88	FALSE
2	GTEx	Adipose Subcutaneous	SLAIN2	0.13	0.04	lasso	4	0.07	1.4e-06	-5.3	5.1	2.9e-07	0.23	0.68	0.03	TRUE
3	GTEx	Adrenal Gland	OCIAD1	0.10	-0.01	enet	11	0.02	5.5e-02	-11.0	-11.3	7.7e-30	-0.82	0.05	0.67	TRUE
4	GTEx	Artery Aorta	OCIAD1	0.09	0.10	lasso	4	0.10	2.4e-06	11.3	-11.4	3.8e-30	-0.92	0.30	0.70	FALSE
5	GTEx	Artery Tibial	OCIAD1	0.09	0.12	enet	6	0.11	1.1e-08	11.6	-11.4	7.1e-30	-0.90	0.34	0.66	FALSE
6	GTEx	Artery Tibial	OCIAD1-AS1	0.07	0.00	enet	13	0.02	7.0e-03	-11.0	7.8	5.2e-15	0.40	0.09	0.29	FALSE
7	GTEx	Brain Cerebellum	OCIAD1	0.10	0.04	lasso	5	0.02	1.1e-01	11.5	-9.9	3.3e-23	-0.82	0.08	0.24	FALSE
8	GTEx	Breast Mammary Tissue	DCUN1D4	0.08	0.02	enet	11	0.04	2.4e-03	8.5	8.5	1.5e-17	0.41	0.07	0.82	FALSE
9	GTEx	Breast Mammary Tissue (Female)	DCUN1D4	0.02	0.03	lasso	1	0.02	8.2e-02	8.5	8.5	1.8e-17	0.48	0.02	0.16	TRUE
10	GTEx	Cells Transformed fibroblasts	DCUN1D4	0.05	0.04	enet	15	0.04	7.8e-04	8.8	7.4	1.5e-13	0.41	0.08	0.85	FALSE
11	GTEx	Colon Sigmoid	OCIAD1	0.08	0.04	lasso	8	0.02	8.6e-02	12.0	-10.0	1.6e-23	-0.87	0.09	0.51	FALSE
12	GTEx	Colon Transverse	OCIAD1	0.07	0.07	lasso	5	0.05	2.8e-03	11.6	-11.5	1.2e-30	-0.90	0.16	0.70	FALSE
13	GTEx	Esophagus Gastroesophageal Junction	OCIAD2	0.07	0.01	lasso	4	0.02	8.3e-02	-7.8	-8.3	1.0e-16	-0.75	0.07	0.50	FALSE
14	GTEx	Esophagus Mucosa	OCIAD1	0.07	0.06	lasso	4	0.06	9.9e-05	11.8	-11.8	4.4e-32	-0.94	0.12	0.87	FALSE
15	GTEx	Esophagus Mucosa	OCIAD1-AS1	0.11	0.01	lasso	7	0.01	1.2e-01	-8.4	6.7	1.8e-11	0.53	0.09	0.10	FALSE
16	GTEx	Esophagus Muscularis	OCIAD1	0.12	0.16	lasso	6	0.17	9.1e-11	11.6	-12.1	9.2e-34	-0.91	0.51	0.49	FALSE
17	GTEx	Heart Atrial Appendage	LRRC66	0.06	0.02	lasso	3	0.01	7.9e-02	9.0	8.2	2.6e-16	0.37	0.05	0.76	FALSE
18	GTEx	Lung	OCIAD1	0.09	0.00	lasso	4	0.00	1.4e-01	-7.0	-8.3	9.8e-17	-0.62	0.05	0.45	FALSE
19	GTEx	Nerve Tibial	SLAIN2	0.10	0.09	lasso	4	0.08	4.2e-06	-5.9	5.9	3.8e-09	0.51	0.88	0.05	FALSE
20	GTEx	Nerve Tibial	OCIAD1	0.14	0.04	enet	25	0.03	3.7e-03	12.4	-10.6	4.9e-26	-0.79	0.05	0.94	FALSE
21	GTEx	Nerve Tibial	DCUN1D4	0.10	0.09	lasso	3	0.10	6.8e-08	8.8	9.1	1.3e-19	0.48	0.04	0.96	FALSE
22	GTEx	Ovary	FRYL	0.12	-0.01	enet	21	0.03	7.2e-02	12.0	12.5	1.0e-35	0.96	0.04	0.70	TRUE
23	GTEx	Skin Sun Exposed Lower leg	FRYL	0.05	0.01	enet	19	0.02	8.6e-03	-8.6	9.1	1.0e-19	0.69	0.09	0.76	FALSE
24	GTEx	Skin Sun Exposed Lower leg	TEC	0.09	0.00	enet	25	0.02	6.2e-03	1.2	-5.7	1.2e-08	-0.37	0.17	0.17	FALSE
25	GTEx	Testis	DCUN1D4	0.19	0.17	enet	14	0.16	8.7e-08	9.0	9.2	5.4e-20	0.46	0.02	0.98	FALSE
26	GTEx	Testis	OCIAD2	0.19	0.09	lasso	3	0.10	3.2e-05	-7.9	8.1	3.8e-16	0.55	0.22	0.17	TRUE
27	GTEx	Thyroid	DCUN1D4	0.03	0.05	lasso	1	0.04	2.4e-04	8.5	8.5	1.8e-17	0.48	0.06	0.87	FALSE
28	GTEx	Thyroid	OCIAD1-AS1	0.05	0.02	lasso	4	0.03	2.0e-03	5.7	6.7	2.1e-11	0.61	0.05	0.69	TRUE
29	NTR	Blood	OCIAD1	0.01	0.01	bslmm	207	0.00	1.8e-02	11.5	-11.4	4.9e-30	-0.85	0.29	0.64	FALSE
30	ROSMAP	Brain Pre-frontal Cortex	OCIAD1	0.06	0.07	enet	13	0.07	3.8e-09	11.6	-10.1	6.4e-24	-0.78	0.99	0.01	FALSE
31	ROSMAP	Brain Pre-frontal Cortex	SGCB	0.03	0.03	enet	9	0.03	7.0e-05	9.1	7.9	2.0e-15	0.50	0.05	0.94	FALSE
32	YFS	Blood	OCIAD2	0.05	0.05	lasso	5	0.04	1.8e-14	-8.6	9.0	1.5e-19	0.58	1.00	0.00	FALSE
33	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	LRRC66	0.06	0.02	blup	37	0.02	5.4e-03	8.4	-6.2	5.6e-10	-0.44	0.06	0.07	TRUE
34	The Cancer Genome Atlas	Breast Invasive Carcinoma	PDGFRA	0.03	0.00	blup	448	0.01	2.3e-02	2.4	-5.3	1.4e-07	0.01	0.03	0.08	TRUE
35	The Cancer Genome Atlas	Colon Adenocarcinoma	LRRC66	0.07	0.03	lasso	3	0.05	8.0e-04	8.4	-8.4	3.8e-17	-0.51	0.03	0.46	FALSE
36	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	OCIAD1	0.05	0.03	enet	8	0.04	1.0e-05	11.6	-9.6	6.4e-22	-0.76	0.04	0.81	FALSE
37	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	SCFD2	0.07	0.06	lasso	2	0.05	7.0e-06	5.5	-5.2	1.8e-07	0.00	0.00	0.99	FALSE
38	The Cancer Genome Atlas	Brain Lower Grade Glioma	SLC10A4	0.05	0.07	blup	36	0.07	6.0e-08	11.8	10.6	4.7e-26	0.88	0.04	0.96	FALSE
39	The Cancer Genome Atlas	Lung Adenocarcinoma	FRYL	0.04	0.00	blup	93	0.01	1.6e-02	12.4	8.0	1.9e-15	0.67	0.02	0.57	FALSE
40	The Cancer Genome Atlas	Lung Adenocarcinoma	SCFD2	0.06	0.02	blup	189	0.02	6.4e-04	-2.4	-5.3	1.3e-07	-0.15	0.03	0.67	TRUE
41	The Cancer Genome Atlas	Lung Adenocarcinoma	SLC10A4	0.03	0.03	lasso	2	0.02	8.1e-04	5.7	5.7	1.0e-08	0.57	0.09	0.40	FALSE
42	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	SLC10A4	0.05	0.02	blup	36	0.03	6.3e-03	-8.5	10.1	3.7e-24	0.87	0.05	0.38	FALSE
43	The Cancer Genome Atlas	Prostate Adenocarcinoma	FRYL	0.03	0.03	enet	8	0.03	3.2e-04	10.6	10.1	3.4e-24	0.88	0.05	0.80	FALSE
44	The Cancer Genome Atlas	Testicular Germ Cell Tumors	SLC10A4	0.09	0.04	lasso	4	0.05	7.5e-03	12.2	12.1	1.6e-33	0.96	0.01	0.84	FALSE
45	The Cancer Genome Atlas	Thyroid Carcinoma	FRYL	0.02	0.01	blup	93	0.01	3.6e-02	11.6	12.0	3.5e-33	0.96	0.03	0.73	FALSE
46	The Cancer Genome Atlas	Thyroid Carcinoma	OCIAD1	0.08	0.05	enet	16	0.06	8.5e-07	11.5	-9.3	1.1e-20	-0.68	0.06	0.88	FALSE