Hub : Genes

TEC

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.1400 0.0410 5.8e-08 0.006 0.071 0.064 0.067 0.050 5.5e-02 5.1e-09 3.4e-08 1.5e-08 9.4e-07
2 GTEx Artery Aorta 0.1090 0.0480 3.4e-03 0.074 NA 0.071 NA 0.089 6.4e-05 NA 9.4e-05 NA 1.3e-05
3 GTEx Artery Tibial 0.0629 0.0306 8.2e-03 0.006 NA 0.011 NA 0.001 1.1e-01 NA 4.5e-02 NA 2.7e-01
4 GTEx Cells Transformed fibroblasts 0.3620 0.0670 1.3e-09 0.169 NA 0.168 NA 0.168 1.1e-12 NA 1.2e-12 NA 1.2e-12
5 GTEx Esophagus Mucosa 0.3400 0.0690 2.7e-08 0.042 NA 0.115 NA 0.150 8.6e-04 NA 4.4e-08 NA 3.4e-10
6 GTEx Heart Atrial Appendage 0.0840 0.0390 7.0e-03 0.005 NA 0.018 NA 0.011 1.8e-01 NA 5.1e-02 NA 1.0e-01
7 GTEx Lung 0.1907 0.0566 5.3e-07 0.152 NA 0.149 NA 0.147 9.9e-12 NA 1.6e-11 NA 2.5e-11
8 GTEx Nerve Tibial 0.0902 0.0404 3.7e-03 -0.002 NA 0.011 NA -0.003 5.3e-01 NA 4.8e-02 NA 6.2e-01
9 GTEx Pituitary 0.2140 0.0830 5.9e-03 -0.012 NA -0.007 NA -0.011 9.6e-01 NA 5.4e-01 NA 8.4e-01
10 GTEx Skin Not Sun Exposed Suprapubic 0.1610 0.0490 1.2e-05 0.169 NA 0.074 NA 0.164 1.5e-09 NA 6.9e-05 NA 2.5e-09
11 GTEx Skin Sun Exposed Lower leg 0.0900 0.0350 8.1e-04 -0.003 NA 0.021 NA 0.010 8.6e-01 NA 6.2e-03 NA 4.4e-02
12 GTEx Whole Blood 0.0800 0.0320 2.7e-03 0.014 NA 0.013 NA 0.011 1.7e-02 NA 2.1e-02 NA 3.3e-02
13 TCGA Head and Neck Squamous Cell Carcinoma 0.0587 0.0368 5.2e-03 -0.001 0.013 0.013 NA 0.002 5.1e-01 1.2e-02 1.2e-02 NA 1.5e-01
14 TCGA Kidney Renal Clear Cell Carcinoma 0.0544 0.0250 9.7e-04 0.013 0.027 0.006 NA 0.007 1.1e-02 4.2e-04 6.8e-02 NA 5.1e-02
15 TCGA Prostate Adenocarcinoma 0.0405 0.0218 7.5e-03 -0.002 0.012 -0.002 NA -0.002 6.4e-01 1.8e-02 7.8e-01 NA 6.2e-01
16 TCGA Thyroid Carcinoma 0.1230 0.0370 8.1e-08 0.108 0.070 0.107 NA 0.103 1.1e-10 2.3e-07 1.3e-10 NA 3.1e-10

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16
Bipolar Disorder (2018) 0.3 0.5 3.2 0.8 0.1 0.2 0.1 -0.4 0.0 -0.4 0.9 -0.7 -0.5 1.2 1.8 0.8 0.1 0.3 -0.0
Bipolar Disorder or Schizophrenia 0.4 0.9 2.4 1.4 0.7 -0.2 -0.5 -0.8 0.0 -1.4 -0.7 -0.7 -1.3 0.4 1.3 1.2 -0.1 1.5 -0.6
Depressed Affect (Nagel 2018) 1.2 2.5 7.5 -0.3 -1.1 -2.7 1.1 -0.5 0.0 -2.3 -2.4 -2.0 -2.7 -1.4 1.4 0.5 -1.5 -0.3 1.3
Depression (Nagel 2018) 0.8 1.2 3.2 -0.0 -0.6 -1.1 1.7 0.0 0.0 -0.9 -0.5 -1.3 -1.7 0.4 1.6 1.5 -0.6 -0.6 1.8
Intelligence (Savage-Jansen 2018) 0.2 0.7 3.8 0.0 0.0 0.6 1.9 0.7 0.0 -0.1 -0.5 -0.7 -0.2 0.6 0.9 0.8 0.2 -0.3 1.8
Neuroticism (Nagel 2018) 0.4 0.9 3.5 -1.0 -0.6 -0.7 0.7 0.0 0.0 -1.0 -1.5 -0.4 -1.9 0.0 1.0 0.2 -1.4 0.8 0.9
Schizophrenia (2018) 0.4 0.9 3.1 1.2 0.8 -0.5 -0.7 -0.7 0.0 -1.4 -1.7 -0.4 -1.3 -0.6 0.2 0.8 -0.2 1.8 -0.7
Schizophrenia vs Biploar Disorder 0.5 0.6 3.3 -0.4 -0.6 -0.7 -0.2 -1.2 0.0 -0.2 -1.1 -0.3 -1.1 -0.9 -1.8 -0.2 -0.7 -0.3 -0.1
Worry (Nagel 2018) 0.2 0.4 1.8 -1.3 -0.7 0.4 0.3 -0.2 0.0 0.4 -0.5 0.7 -0.4 1.0 0.1 -0.3 -1.2 0.7 0.3
Alzheimer’s Disease (in mother) 0.7 0.8 1.6 -0.8 0.6 0.1 1.2 1.1 0.0 -1.2 -1.2 -0.9 -0.6 -0.9 0.4 0.9 -0.7 1.2 1.3
Alzheimer’s Disease (in father) 0.2 0.3 2.0 0.4 0.2 0.6 0.3 0.0 0.0 0.2 -0.5 0.4 1.4 -0.5 -0.3 0.6 0.4 0.6 0.2
Alzheimer’s Disease (including proxy) 0.3 0.4 1.0 -0.2 -0.2 -0.3 0.9 0.2 0.0 -0.7 -0.8 -0.7 -0.1 -0.7 0.7 0.9 -1.0 1.0 0.9
Crohns Disease (2017) 2.1 4.5 12.3 1.6 -0.2 2.6 -2.4 -0.4 0.0 3.1 0.4 3.1 3.3 -0.8 -3.5 -0.3 2.5 -0.7 -2.6
Irritable Bowel Disease (IBD) 0.8 2.0 6.0 1.4 0.0 2.3 -0.6 -0.1 0.0 1.8 0.6 2.2 1.8 -0.3 -2.5 0.6 2.0 -0.8 -0.9
Ulcerative Colitis (UC) 0.2 0.4 1.6 0.6 0.3 1.3 0.9 0.2 0.0 -0.1 0.5 0.5 -0.1 0.3 -1.0 0.9 1.0 -0.5 0.7
Major Depression (MDD) 4.4 5.3 16.7 -1.2 -2.2 -4.1 2.7 -0.1 0.0 -1.7 -0.4 -3.6 -3.0 -1.3 2.9 0.9 -1.0 -2.5 3.2
Reaction Time 0.8 1.5 3.9 1.1 1.4 -0.4 0.8 1.3 0.0 -2.0 -1.9 -0.9 -1.4 0.3 1.4 1.4 0.2 1.7 0.9
Verbal and Numeric Reasoning (VNR) 0.1 0.1 0.5 0.0 -0.5 -0.2 0.7 -0.4 0.0 0.1 -0.1 -0.5 -0.7 -0.0 0.2 0.0 -0.2 -0.4 0.7
Breast Cancer 2.1 5.0 13.4 2.1 2.6 1.3 3.7 3.6 0.0 -2.3 -1.0 -0.7 -0.1 1.3 1.9 3.1 2.8 -0.3 3.3
Ovarian Cancer 1.1 1.5 4.5 -2.1 -1.1 0.8 -0.7 -1.0 0.0 1.4 2.1 1.0 0.4 1.5 -0.4 -1.8 -1.6 -0.2 -0.6
Prostate Cancer 0.2 0.3 1.8 -1.4 -0.2 -0.3 -0.7 -0.6 0.0 0.7 -0.0 -0.2 0.1 -0.3 -0.4 -1.0 -0.6 -0.0 -0.7
Age at First Birth 0.9 1.3 5.2 0.7 1.7 1.3 0.8 2.3 0.0 0.2 0.3 0.1 1.6 0.3 -0.5 0.6 2.2 0.8 0.7
Bipolar Disorder (2011) 0.3 0.3 1.4 -0.2 -0.4 0.2 -0.9 -0.9 0.0 0.0 1.2 -0.1 -0.1 0.1 0.4 -0.6 -0.4 0.4 -1.0
Body Mass Index (BMI) (2010) 1.1 1.5 5.0 0.9 1.7 1.6 1.1 1.4 0.0 -1.1 -2.2 0.9 -0.3 0.4 -0.4 1.6 1.2 1.4 1.0
Coronary Artery Disease (CAD) 1.0 1.2 4.9 -0.7 0.2 0.1 -2.2 -1.0 0.0 -0.0 -0.5 0.1 -0.3 -1.9 -1.6 -0.4 -1.0 0.7 -2.1
Crohns Disease (2012) 2.5 4.0 10.8 0.9 -0.5 2.0 -3.1 -1.1 0.0 3.1 0.7 3.1 3.0 0.8 -2.0 -1.4 1.2 -0.0 -3.3
Mean Putamen Volume 0.8 1.0 3.1 -0.3 -0.1 0.6 -1.5 -1.2 0.0 0.6 -0.1 1.0 1.4 0.5 -1.6 -0.8 0.6 0.7 -1.8
Fasting Glucose 1.3 1.5 6.2 -1.2 -1.4 -1.1 -0.2 -1.5 0.0 -0.8 1.5 -0.6 -2.5 -1.6 -0.2 -0.8 -2.1 -0.7 0.2
HbA1C 1.1 1.2 4.6 2.1 0.9 -1.0 0.0 0.4 0.0 -1.5 -1.4 -0.5 -0.8 -1.7 0.9 1.9 0.7 0.2 0.2
HDL Cholesterol 0.7 1.2 5.0 2.1 1.5 0.5 1.1 1.5 0.0 -0.9 0.2 -0.3 0.1 -0.3 0.1 2.2 1.4 0.8 0.8
LDL Cholesterol 1.1 1.8 5.2 -0.9 -2.1 -2.0 -0.2 -2.3 0.0 0.1 -0.2 -1.7 -1.8 -0.8 -0.4 -1.1 -1.7 -1.7 0.0
Lupus 0.5 0.8 3.0 -1.0 -0.2 -0.4 1.4 0.5 0.0 0.4 0.8 -1.7 -0.1 0.1 1.6 0.9 -0.6 -0.5 1.4
Neuroticism (2016) 0.2 0.2 1.7 -0.2 0.1 -0.1 -0.1 -0.1 0.0 0.7 0.3 -0.1 0.3 0.5 1.3 0.4 -0.6 0.5 -0.1
Primary Biliary Cirrhosis 2.1 3.0 7.5 -2.3 -0.7 1.7 -1.4 0.0 0.0 2.6 2.2 1.8 2.7 2.4 -1.1 -2.5 -0.3 -0.3 -1.4
Rheumatoid Arthritis 3.7 5.1 17.7 -2.2 -2.4 -0.3 0.5 -0.6 0.0 2.9 3.7 0.3 1.5 4.2 0.8 -3.2 -1.5 -3.8 0.5
Schizophrenia (2014) 0.7 1.5 4.3 2.1 0.9 -0.7 -0.7 -1.2 0.0 -1.9 -1.5 -0.9 -1.9 -0.8 0.7 1.5 0.0 1.5 -0.8
Triglycerides 0.6 1.0 7.1 0.2 0.9 0.8 0.1 0.0 0.0 -1.1 -2.7 -0.0 -1.0 -0.2 -0.9 0.9 0.8 1.5 0.1
Type 2 Diabetes (T2D) (2012) 0.3 0.3 2.5 -0.5 -0.1 0.7 -0.2 -0.2 0.0 -0.4 -0.4 0.2 -0.3 -0.8 -1.6 -0.1 -0.7 0.5 -0.2
Ulcerative Colitis 0.2 0.3 0.7 -0.2 0.4 0.8 0.5 0.4 0.0 0.7 0.4 0.4 0.4 0.4 -0.8 0.6 0.6 0.4 0.4
Blood Eosinophil Count 0.8 6.2 21.0 4.3 3.8 2.1 0.3 2.4 0.0 -2.1 -2.7 1.0 1.2 -1.1 0.4 3.4 4.6 2.7 0.0
Blood Platelet Count 0.4 4.8 22.4 2.2 1.7 1.8 2.5 2.9 0.0 -0.3 2.2 -0.6 2.1 0.3 3.2 1.8 4.7 -1.2 2.0
Blood Red Count 0.3 3.4 11.0 -0.5 1.4 2.7 -0.1 1.7 0.0 2.2 0.2 2.1 3.3 3.1 -1.5 -1.5 2.6 -0.3 -0.4
Blood White Count 0.3 2.2 8.4 2.9 0.8 -0.9 -0.3 -0.1 0.0 -1.9 -2.5 -1.7 -0.5 -2.7 -0.2 1.4 1.6 0.3 -0.4
Heel T-Score 0.4 3.3 7.1 2.2 1.9 -0.2 1.9 2.4 0.0 -2.5 -1.8 0.0 -2.1 -0.6 2.2 2.7 1.9 0.6 2.1
BMI 0.3 2.0 8.3 1.4 -0.3 -1.5 -0.5 -0.8 0.0 -1.9 -2.9 -0.9 -2.2 -2.5 1.1 0.7 -0.8 0.6 -0.0
Height 0.3 5.3 32.5 -0.6 1.0 -1.2 2.4 1.8 0.0 -1.3 -1.4 -3.9 -1.2 -5.7 -0.8 3.0 1.9 0.2 2.7
Waist Hip Ratio (WHR) 0.2 1.1 4.2 -0.4 0.5 0.1 -1.7 -0.5 0.0 -1.1 -0.9 0.2 0.1 -1.1 -1.5 -1.3 -0.2 2.1 -1.6
Systolic Blood Pressure 0.4 1.8 5.3 2.2 2.3 1.0 -0.7 1.1 0.0 -0.5 -1.4 -0.2 0.8 -2.2 -0.4 1.0 2.2 1.2 -0.9
Smoking Status 1.2 2.8 9.8 2.3 0.5 -1.8 -1.3 -1.4 0.0 -2.9 -1.9 -1.7 -1.9 -3.1 -0.0 0.7 0.3 1.6 -1.2
Allergy or Eczema 1.3 3.5 14.7 2.8 2.6 1.8 -0.1 1.7 0.0 -0.7 -2.4 1.0 1.7 -0.6 -0.6 2.1 3.8 2.0 -0.6
Cardiovascular Disease 0.3 0.8 5.0 0.2 -0.7 -2.0 -0.9 -0.9 0.0 0.2 -1.3 -0.4 -0.1 -2.2 -0.3 -0.3 -0.2 -0.3 -0.6
Hypothyroidism (self reported) 1.1 2.6 9.1 2.7 2.3 0.3 -1.1 0.6 0.0 -1.7 -3.0 0.9 -0.9 -0.7 -0.2 1.8 1.6 2.4 -1.2
Respiratory disease 0.7 1.5 7.9 0.3 0.4 0.9 -1.9 -0.3 0.0 1.5 -0.3 2.8 1.1 0.9 -1.1 -0.9 0.9 0.7 -2.0
Type 2 Diabetes (T2D) (2018) 0.2 0.3 0.9 -0.3 0.8 0.4 -0.8 0.5 0.0 0.4 -0.7 0.6 0.4 -0.8 -0.3 -0.2 0.6 0.9 -0.6
Lung FEV1/FVC ratio 0.6 3.0 14.5 -2.3 -1.2 -1.1 2.2 0.9 0.0 -0.3 1.6 -3.8 -2.3 0.4 1.6 0.2 -0.8 -1.7 2.5
Lung FVC 0.3 1.8 10.7 -1.2 -1.0 1.0 0.7 -0.5 0.0 1.4 2.1 1.4 1.2 3.3 0.7 -1.1 -0.7 -1.2 0.4
Neuroticism 0.5 1.2 5.8 0.3 -0.2 -0.9 -0.0 -0.4 0.0 -1.6 -2.4 -0.3 -2.1 -1.3 0.9 0.4 -1.1 1.3 0.2
Chronotype (morning person) 0.8 1.9 8.5 0.4 1.1 2.9 -0.6 0.0 0.0 1.5 -0.2 1.5 2.0 2.8 -1.0 -0.7 1.1 0.1 -1.0
Hair Pigment 0.0 1.3 6.6 0.9 -0.6 -1.1 -1.6 -1.5 0.0 0.2 -1.4 -0.5 0.5 -2.6 -1.2 -0.3 -0.2 -0.1 -1.6
Tanning 0.2 2.4 6.7 0.3 1.8 2.5 -0.5 1.2 0.0 1.4 -0.1 2.6 2.5 1.5 -1.9 -0.1 2.0 1.8 -0.7
Hand grip strength (left) 0.3 0.9 2.9 0.3 -0.1 -0.8 1.2 0.2 0.0 -1.3 0.7 -1.2 -1.7 -0.3 1.4 1.2 -0.6 0.2 1.3
Number of treatments/medications taken 0.4 0.7 2.7 0.0 1.0 0.9 -0.9 0.2 0.0 0.8 -0.5 1.6 1.2 0.3 -0.1 -0.5 1.4 0.7 -1.0
Average weekly spirits intake 0.2 0.2 0.8 0.3 -0.1 0.6 -0.3 0.1 0.0 0.7 0.3 -0.2 0.9 0.6 0.7 -0.2 0.0 0.7 -0.5
Sensitivity / hurt feelings 0.2 0.4 1.7 1.3 0.1 1.1 -0.6 -0.4 0.0 0.2 0.1 0.2 -0.1 0.5 0.2 0.3 -0.6 1.2 -0.8
Frequency of depressed mood in last 2 weeks 0.6 0.9 3.2 0.4 -0.1 -1.1 0.6 0.0 0.0 -1.5 -0.8 -1.5 -1.8 -1.0 0.3 1.6 -0.4 0.6 0.7
Hearing difficulty/problems: Yes 0.5 0.7 2.9 -1.0 0.5 -0.3 1.7 1.4 0.0 0.2 -0.1 -0.2 0.1 0.7 1.1 0.6 0.9 -0.3 1.7
Relative age of first facial hair 0.6 1.3 4.3 0.2 0.5 -0.2 -1.9 -0.6 0.0 0.1 -2.0 1.3 -0.1 -0.3 -2.1 -0.7 0.7 1.2 -1.8
Other serious medical condition/disability diagnosed by doctor 0.6 0.7 2.6 -0.7 -0.9 0.2 -0.8 -1.1 0.0 0.9 1.1 0.5 0.2 1.1 -0.1 -1.4 0.1 -1.6 -0.8
Ever used hormone-replacement therapy (HRT) 0.4 0.5 1.2 0.1 1.0 0.5 0.6 0.9 0.0 -0.5 1.0 0.6 0.7 1.1 1.0 0.1 0.2 0.5 0.4
Ever had hysterectomy (womb removed) 1.7 1.9 6.3 0.7 1.4 0.4 -1.9 -0.6 0.0 -1.5 -2.3 1.2 -0.5 -1.1 -2.1 0.0 -0.0 2.5 -1.8
Systolic blood pressure, automated reading 0.7 2.0 10.6 2.3 1.4 0.2 -0.2 0.8 0.0 -1.2 -2.5 0.7 -0.8 -3.2 -0.6 1.1 1.6 0.7 -0.1
Eye problems/disorders: Diabetes related eye disease 0.5 0.5 1.3 -0.6 0.6 -0.4 0.9 0.7 0.0 -0.4 0.9 -1.1 -0.6 -0.1 1.1 0.8 -1.0 -0.2 1.0
Angina 0.5 0.7 3.2 0.3 -0.4 -0.4 -1.7 -1.5 0.0 0.8 -0.2 -0.1 -0.0 -0.4 -0.4 -0.8 -0.6 -0.3 -1.8
Medication for hormone replacement therapy 0.6 0.7 2.9 0.2 0.9 1.2 -0.2 0.8 0.0 0.9 0.2 0.9 1.5 1.7 0.5 -0.1 0.5 0.9 -0.5
Vitamin and mineral supplements 0.7 0.9 3.5 0.2 -0.0 -0.1 1.6 1.3 0.0 -0.2 0.1 -1.9 0.4 -1.0 0.9 1.2 0.2 -0.7 1.6
Supplements: Zinc 1.3 1.4 5.2 -0.3 -0.8 -0.0 -2.2 -2.3 0.0 0.7 0.6 0.5 -0.1 -0.3 -1.0 -1.9 -1.2 0.2 -2.1
Medication: Co-codamol 0.4 0.4 1.5 -0.1 -0.9 -0.4 -0.1 -0.4 0.0 0.7 -1.1 0.6 -1.2 0.3 1.1 -0.1 -0.7 -0.2 0.1
Medication: Metformin 0.3 0.5 2.1 -0.3 1.4 0.8 -0.3 0.7 0.0 -0.1 -0.6 0.3 0.5 -1.0 0.2 -0.0 1.0 1.1 -0.3
Diabetes (father) 0.5 0.6 3.0 -0.3 0.5 0.5 -1.1 0.5 0.0 1.0 0.3 0.5 1.7 0.1 -0.1 -1.3 0.4 0.4 -1.2
Diabetes (mother) 0.6 0.8 2.1 0.8 1.3 -0.3 -0.1 0.4 0.0 -1.4 -1.5 1.0 -1.2 -0.5 -0.2 0.6 0.9 1.2 0.1
Severe depression (siblings) 1.1 1.2 4.6 1.6 1.3 0.4 0.5 0.8 0.0 -1.7 -0.7 -2.1 -0.5 -0.6 1.1 1.9 0.7 0.5 0.5
Pack years adult smoking proportion 0.5 0.7 3.7 -0.5 0.4 0.0 0.8 0.1 0.0 -1.2 -1.9 -1.0 -0.4 -0.6 -1.0 1.2 0.0 1.0 0.8
Impedance of leg (right) 0.4 2.1 8.7 0.5 0.5 -0.8 -2.6 -1.4 0.0 0.3 -1.0 1.1 0.7 -1.6 -3.0 -1.2 0.3 0.8 -2.8
Leg fat-free mass (left) 0.4 2.1 7.0 -0.2 -0.2 -0.7 1.7 0.8 0.0 -1.5 -1.1 -2.6 -2.1 -2.4 1.0 1.7 -0.1 -0.4 2.1
Trunk fat percentage 0.9 3.7 17.6 1.4 0.1 -1.4 -1.6 -1.5 0.0 -2.6 -4.2 -0.7 -2.1 -4.1 -0.9 0.4 0.1 0.9 -1.3
Hand grip strength (right) 0.2 0.6 2.7 -0.8 -0.3 -0.3 -0.5 -0.7 0.0 -0.4 1.4 -0.4 -1.0 -1.2 0.2 -0.6 -1.6 0.5 -0.2
Townsend deprivation index at recruitment 2.0 2.8 11.5 1.6 -0.0 -2.0 -1.0 -1.0 0.0 -2.3 -1.4 -3.4 -2.2 -3.3 0.7 1.1 0.4 -0.2 -0.7
Current tobacco smoking 0.8 1.4 4.4 1.9 1.2 0.4 -0.0 0.5 0.0 -2.1 -1.2 -0.9 -0.7 -2.1 -0.6 1.1 1.6 1.0 -0.1
Average weekly fortified wine intake 0.7 0.8 4.9 -0.2 -0.1 1.1 0.3 0.3 0.0 0.9 1.4 0.3 1.1 2.2 1.1 -0.7 -0.5 -1.1 0.1
Maternal smoking around birth 0.8 1.1 2.6 -1.3 -1.2 -0.8 -1.6 -1.3 0.0 -0.1 0.8 0.5 0.1 -1.2 -1.4 -1.6 -1.3 0.1 -1.3
Fed-up feelings 1.7 3.1 10.0 0.2 -1.1 -3.2 0.3 -1.3 0.0 -2.3 -1.9 -2.8 -3.0 -2.2 1.5 0.6 -1.7 -0.1 0.6
Frequency of unenthusiasm / disinterest in last 2 weeks 0.3 0.4 2.5 0.3 0.0 -0.6 1.0 0.2 0.0 -0.6 -0.4 -0.3 -0.6 0.5 1.1 1.6 0.1 0.2 0.9
Relative age voice broke 0.1 0.2 0.5 -0.7 0.5 -0.6 -0.2 0.2 0.0 -0.4 -0.4 -0.6 -0.2 -0.2 0.5 -0.5 0.7 0.7 -0.0
Taking other prescription medications 1.0 1.5 6.2 1.9 1.3 0.2 -1.4 -0.1 0.0 -0.8 -2.5 1.1 -0.2 -1.0 0.3 0.3 1.0 2.1 -1.4
Age when periods started (menarche) 0.6 1.4 5.2 1.0 2.1 -0.6 -0.3 1.2 0.0 -2.3 -1.1 -0.8 -0.4 -0.6 1.0 1.0 1.0 2.2 -0.3
Bilateral oophorectomy (both ovaries removed) 0.6 0.7 2.2 0.0 1.0 -0.0 0.9 1.1 0.0 -1.5 0.2 -0.2 -1.2 -0.5 1.4 0.2 0.1 0.0 1.1
Heel bone mineral density (BMD) T-score, automated (left) 0.4 0.9 7.3 2.7 0.3 0.0 -0.9 -0.9 0.0 -0.4 -0.6 1.0 -0.3 -1.1 -0.5 0.5 1.3 0.0 -1.1
Tinnitus: Yes, but not now, but have in the past 0.9 0.9 3.7 -1.6 -0.6 -0.8 -0.4 -1.0 0.0 -0.4 0.7 -1.3 -0.5 -1.2 0.0 -1.9 -1.5 -0.4 -0.2
Qualifications: CSEs or equivalent 0.3 0.4 1.1 0.6 -0.2 -0.9 -0.9 -0.6 0.0 -0.5 -0.8 0.8 -0.1 -1.1 -0.4 0.2 -0.1 0.8 -0.9
Serious illness, injury or assault to yourself 0.9 1.0 3.6 0.6 0.5 0.3 1.2 0.9 0.0 -1.7 -0.9 -1.2 -0.7 0.2 1.9 1.4 1.1 -0.1 1.2
High blood pressure 0.2 0.7 1.6 -0.2 -0.5 -0.0 -1.2 -1.0 0.0 1.1 0.1 1.1 0.9 -1.1 -0.9 -1.3 0.3 -0.3 -1.1
Hayfever, allergic rhinitis or eczema 0.6 1.3 5.3 1.4 1.3 1.3 -0.4 0.4 0.0 -0.2 -1.9 0.8 1.1 -0.3 -0.7 0.9 2.3 1.5 -0.7
Multivitamins +/- minerals 0.9 1.1 3.8 0.8 0.5 0.2 -1.6 -1.2 0.0 -0.4 -0.7 2.0 -0.0 0.8 -1.5 -0.5 0.0 1.5 -1.7
Stomach or abdominal pain in last month 0.5 0.6 2.3 -0.7 -0.8 -0.5 -1.0 -1.5 0.0 -0.3 -0.3 0.1 -0.8 0.0 -0.3 -0.4 -1.4 1.1 -1.0
Supplements: Glucosamine 0.5 0.7 2.4 0.9 0.6 0.2 1.6 1.3 0.0 -0.2 -0.3 -0.3 0.1 -0.1 0.3 1.2 1.1 -0.7 1.4
Diverticular disease/diverticulitis (self-reported) 1.0 1.2 4.5 -0.1 -0.9 -0.9 -1.4 -2.1 0.0 0.5 -0.5 0.5 -0.9 -1.8 -1.3 -0.8 -1.4 0.8 -1.2
Medication: Atenolol 0.9 1.2 3.3 1.1 1.5 1.7 -1.1 0.5 0.0 1.0 -0.3 1.5 0.8 0.6 -0.5 0.9 0.7 1.8 -1.3
Medication: Levothyroxine sodium 1.5 2.5 6.6 2.6 2.1 1.3 -2.1 0.1 0.0 -0.4 -2.2 1.7 0.6 0.2 -0.3 0.7 1.5 2.4 -2.4
Sitting height 0.6 4.3 15.8 1.0 0.8 -1.9 2.0 1.2 0.0 -1.8 -1.4 -4.0 -2.2 -3.8 1.4 3.3 0.1 0.2 2.2
Chronic bronchitis/emphysema (father) 0.9 1.1 3.2 -1.5 -0.8 -0.7 0.1 -1.4 0.0 -0.9 -1.3 1.0 -1.8 -0.7 -1.6 -0.3 -1.5 0.4 0.4
High blood pressure (mother) 0.4 0.6 3.4 0.5 0.9 -0.5 0.3 0.6 0.0 -1.1 -1.8 0.7 -1.0 -0.5 1.0 0.2 0.2 0.5 0.6
Body mass index (BMI) 0.4 1.6 8.1 1.1 -0.3 -0.9 0.1 -0.4 0.0 -1.9 -2.9 -0.6 -1.8 -2.1 1.1 1.1 -0.4 0.5 0.4
Impedance of leg (left) 0.5 2.4 9.5 0.6 0.6 -0.7 -2.8 -1.5 0.0 0.1 -1.1 1.2 0.6 -1.5 -3.1 -1.3 0.4 0.9 -3.0
Leg predicted mass (left) 0.4 2.2 7.2 -0.2 -0.2 -0.7 1.8 0.9 0.0 -1.5 -1.2 -2.7 -2.2 -2.4 1.0 1.8 -0.1 -0.4 2.2
Trunk fat mass 0.8 3.6 18.5 1.4 0.1 -1.6 -1.0 -1.0 0.0 -2.6 -4.0 -1.3 -2.4 -4.3 -0.5 0.9 0.1 0.7 -0.6
Waist circumference 0.6 2.3 9.8 0.4 -0.8 -1.5 -0.5 -1.4 0.0 -2.1 -3.1 -1.0 -2.4 -3.0 -0.2 0.4 -0.9 0.5 -0.2
Number of incorrect matches in round 0.4 0.7 4.1 -1.4 -0.4 0.1 -0.2 -0.3 0.0 0.5 2.0 -0.4 0.2 0.7 -0.7 -1.2 -0.9 -1.3 -0.1
Past tobacco smoking 0.7 1.2 3.5 -1.9 -0.4 1.2 1.4 0.9 0.0 1.5 0.8 0.5 0.8 1.6 -0.3 -0.0 0.8 -1.4 1.4
Alcohol usually taken with meals 1.3 2.0 8.2 -0.7 0.3 2.5 -0.2 0.6 0.0 2.5 0.9 2.1 2.9 1.1 -1.4 -1.2 0.9 -0.4 -0.4
Nervous feelings 0.3 0.5 1.9 0.3 0.6 0.2 0.3 0.7 0.0 -0.3 -1.4 -0.2 -0.5 -1.1 -0.1 1.1 0.3 1.3 0.3
Frequency of tenseness / restlessness in last 2 weeks 0.8 1.3 3.6 0.4 -0.0 -1.3 -0.3 -0.8 0.0 -1.4 -1.6 -1.6 -1.9 -1.8 -0.0 1.4 -0.6 1.2 -0.3
Hearing difficulty/problems with background noise 0.1 0.1 0.7 -0.2 0.1 0.5 -0.2 -0.1 0.0 0.1 -0.3 0.1 0.4 0.5 0.6 -0.3 -0.3 0.8 -0.3
Hair/balding pattern: Pattern 2 0.4 0.5 2.8 0.5 0.1 -0.8 0.5 0.4 0.0 -0.8 -0.7 -0.9 -0.9 -1.7 0.5 0.7 -0.1 -0.4 0.6
Had menopause 1.2 1.5 3.7 1.9 1.7 1.4 0.9 1.7 0.0 0.1 0.5 -0.3 1.3 1.7 1.4 1.3 1.5 -0.6 0.5
Had other major operations 0.2 0.3 1.5 0.1 1.1 0.5 -0.3 0.3 0.0 0.1 0.2 0.1 0.0 1.2 0.7 0.2 -0.6 0.7 -0.4
Forced vital capacity (FVC) 0.3 1.2 3.8 -1.6 -1.2 -0.6 -1.0 -1.4 0.0 0.9 1.8 -0.3 -0.2 0.0 -0.6 -1.7 -1.9 0.0 -0.9
Heel bone mineral density (BMD) T-score, automated (right) 0.5 1.3 7.0 2.6 0.3 -0.2 0.4 -0.2 0.0 -1.3 -1.4 0.9 -1.2 -1.3 0.3 1.5 1.6 -0.2 0.3
Ever unenthusiastic/disinterested for a whole week 1.4 1.7 6.2 -0.5 -0.0 -1.1 1.6 0.2 0.0 -2.5 -1.5 -1.7 -1.6 -0.9 0.2 2.1 0.0 1.0 1.8
Qualifications: None of the above 0.3 0.6 3.0 0.9 0.4 0.2 -1.7 -0.8 0.0 -0.5 -0.8 -0.4 -0.3 -0.9 -0.2 -0.2 0.2 0.8 -1.7
Financial difficulties in last 2 years 1.0 1.3 4.1 -0.5 -1.3 -2.0 -0.6 -1.2 0.0 -1.0 -0.7 -1.7 -2.0 -1.9 -0.5 -0.3 -0.8 -1.0 -0.3
Mouth/teeth dental problems 0.7 1.1 3.3 0.9 -1.2 -0.2 1.8 -0.1 0.0 0.6 1.6 -0.5 0.5 1.2 1.1 0.2 -0.1 -1.7 1.6
Heart attack 0.7 0.9 6.4 -0.1 -0.2 -0.2 -0.2 -0.3 0.0 -0.9 -2.5 0.4 -0.8 -0.6 -1.1 0.8 -0.4 1.7 -0.1
Allergy 0.5 1.1 3.0 -0.5 -0.6 -1.3 1.1 0.5 0.0 -0.6 1.4 -1.7 -1.3 -0.5 1.1 0.2 -1.7 -1.2 1.4
Pain all over the body in last month 0.3 0.3 1.1 0.3 -0.5 -0.9 -0.3 -0.3 0.0 -0.3 0.2 -0.1 -0.4 -0.7 0.7 -0.4 -1.0 -0.6 -0.2
Diabetes (self-reported) 0.4 0.5 2.7 0.8 1.6 0.7 0.5 1.2 0.0 -0.6 -0.2 0.2 0.1 -0.8 0.3 0.6 1.2 -0.0 0.5
Hayfever/allergic rhinitis (self-reported) 0.8 1.1 4.6 0.0 1.2 1.2 -1.5 0.0 0.0 -0.3 -1.6 -0.1 0.3 -0.9 -1.0 0.3 1.2 2.1 -1.5
Medication: Ramipril 0.1 0.2 0.9 -0.2 0.4 0.6 -0.1 -0.1 0.0 -0.5 -0.9 0.2 -0.1 -0.4 -0.8 -0.2 0.4 0.4 -0.1
Medication: Simvastatin 0.9 1.4 4.8 -1.3 -1.0 -1.5 -0.6 -1.6 0.0 -0.2 -2.2 0.2 -1.2 -1.9 -0.8 -0.4 -1.6 0.7 -0.3
Fluid intelligence score 0.3 0.7 2.5 0.3 -1.4 -1.0 -0.6 -1.6 0.0 0.4 -0.2 0.0 -1.2 -0.5 -0.1 -0.9 -1.1 -0.7 -0.5
Illnesses of siblings 0.3 0.4 1.7 -0.6 -0.9 0.0 -0.1 -0.0 0.0 0.8 1.3 -0.7 0.5 0.5 0.9 -0.4 -0.6 -0.5 -0.1
Neuroticism score 1.0 2.2 8.7 0.7 -0.1 -1.5 -0.6 -0.9 0.0 -2.2 -3.0 -1.2 -2.5 -2.0 0.1 0.6 -1.4 1.9 -0.4
Weight 0.7 3.5 16.6 1.0 -0.1 -1.7 0.5 -0.2 0.0 -2.6 -3.3 -2.2 -2.8 -4.1 0.5 1.8 -0.2 0.3 0.9
Impedance of arm (right) 0.4 1.7 8.2 -0.4 0.2 0.3 -2.1 -1.3 0.0 0.1 -0.4 0.9 0.6 -1.8 -2.9 -1.2 0.4 0.9 -2.2
Arm fat percentage (right) 0.6 2.2 13.1 1.2 -0.0 -0.6 -0.8 -0.8 0.0 -2.1 -3.6 -0.3 -1.7 -3.0 -0.1 0.8 0.1 1.0 -0.6
Trunk fat-free mass 0.4 2.5 7.3 0.2 0.5 -0.5 2.4 1.8 0.0 -1.0 -0.8 -2.7 -1.7 -2.0 1.2 2.6 0.3 -0.3 2.7
Hip circumference 0.6 2.7 10.2 0.2 -1.7 -2.3 -0.3 -1.7 0.0 -1.6 -2.5 -1.2 -3.2 -2.8 0.1 0.6 -1.5 -0.3 0.3
Time employed in main current job 1.2 1.4 4.9 -1.1 0.3 -0.3 2.1 1.6 0.0 0.4 1.2 -0.5 -0.1 0.3 2.2 0.6 0.1 -1.1 2.2
Alcohol intake versus 10 years previously 0.3 0.5 4.0 0.6 0.3 -0.0 -0.6 -0.2 0.0 0.0 -1.1 1.1 -0.1 -0.0 -2.0 0.6 0.2 0.1 -0.6
Father’s age at death 1.5 2.0 6.1 2.5 2.2 2.2 0.6 2.3 0.0 -0.3 -0.4 0.8 1.3 1.5 -0.2 1.5 1.7 0.6 0.2
Worrier / anxious feelings 0.8 1.5 4.3 -1.0 -0.3 0.9 -1.5 -0.3 0.0 1.8 0.4 1.4 2.1 0.1 -1.9 -1.4 -0.3 1.1 -1.6
Frequency of tiredness / lethargy in last 2 weeks 0.3 0.5 3.7 0.6 -0.5 -0.7 -0.4 -0.9 0.0 -0.6 -0.6 -0.1 -0.9 -0.3 1.9 -0.0 -0.7 0.3 -0.3
Falls in the last year 0.2 0.3 1.0 1.0 0.6 0.3 -0.3 0.3 0.0 -0.4 -0.2 -0.3 0.0 -0.8 0.9 0.5 -0.3 0.8 -0.4
Hair/balding pattern: Pattern 3 0.2 0.3 1.8 -0.2 0.2 0.3 -0.7 -0.2 0.0 -0.0 -0.0 0.8 0.0 0.1 -1.3 -0.3 0.1 1.0 -0.5
Number of live births 0.7 1.0 3.0 -1.0 0.7 0.5 1.7 1.4 0.0 -0.8 0.1 -0.7 -0.4 1.1 1.5 0.9 -0.3 0.6 1.7
Forced expiratory volume in 1-second (FEV1) 0.4 1.3 4.5 -1.8 -1.5 -0.8 0.0 -1.0 0.0 0.8 2.1 -1.1 -0.6 0.4 0.0 -1.4 -1.9 -0.8 0.1
Pulse rate 0.2 0.3 1.2 -0.1 0.2 0.5 0.3 0.1 0.0 -1.1 -0.5 0.5 -0.8 -0.3 -0.8 0.2 -0.5 0.8 0.3
Happiness 0.3 0.4 1.9 -1.4 -0.9 -0.2 0.6 -0.0 0.0 0.4 0.8 -0.6 0.5 0.8 0.5 0.2 -0.6 0.1 0.7
Noisy workplace 1.0 1.2 5.9 -1.3 -0.3 -1.2 1.4 -0.1 0.0 -0.4 -0.0 -2.0 -0.7 -0.2 2.4 0.6 -0.9 -0.8 1.5
Qualifications: A levels/AS levels or equivalent 0.8 1.7 5.8 0.5 1.7 1.8 2.1 2.4 0.0 -0.4 0.7 -0.4 0.1 0.1 0.0 1.6 1.7 0.1 2.0
Serious illness, injury or assault of a close relative in last 2 years 0.8 0.9 3.2 -0.4 0.4 0.7 -1.8 -0.5 0.0 1.3 -0.3 0.9 1.6 0.6 0.1 -1.4 0.3 0.6 -1.8
Mouth/teeth dental problems: Dentures 0.7 1.1 4.8 -1.1 0.6 -0.5 -0.6 0.2 0.0 -1.2 -2.2 -0.4 -1.6 -2.0 -1.2 0.6 -0.1 0.8 -0.4
Asthma 0.6 1.2 5.9 -0.1 -0.3 0.3 -1.5 -1.2 0.0 0.8 -1.6 2.4 -0.1 0.6 -1.5 -0.5 0.2 0.8 -1.5
Medication: Ibuprofen (e.g. Nurofen) 1.5 1.9 7.8 -0.6 -0.1 0.3 -2.7 -1.2 0.0 1.0 0.0 1.2 1.8 1.0 -1.4 -2.0 0.2 0.6 -2.8
Medication: Cholesterol lowering 0.2 0.3 1.8 0.6 0.1 -0.5 0.1 0.2 0.0 0.1 -0.5 0.1 0.4 -1.0 1.3 0.3 0.4 -0.5 0.2
Depression (self-reported) 0.8 1.0 4.8 0.3 -0.9 -2.2 -0.6 -1.0 0.0 -0.8 -0.8 -1.3 -1.1 -1.3 0.9 -0.1 -1.1 0.2 -0.5
Medication: Lansoprazole 0.2 0.2 1.2 0.7 0.4 -0.3 -0.4 0.1 0.0 0.1 -0.3 0.0 -0.1 0.9 1.1 0.2 0.1 0.2 -0.4
Prospective memory result 0.9 1.2 2.9 -1.7 -0.5 1.3 -1.7 -0.9 0.0 1.3 -0.1 0.4 0.7 0.9 -1.0 -1.7 -0.4 0.6 -1.6
Lung cancer (father) 0.4 0.5 2.3 -0.2 0.6 -0.8 -0.6 -0.3 0.0 -0.9 0.9 -1.5 0.2 -0.7 0.6 -0.2 -0.1 0.9 -0.6
Illnesses of mother 1.3 1.6 11.2 -1.4 -1.0 0.4 0.0 0.0 0.0 1.4 3.3 -1.4 1.5 1.1 0.1 -0.8 0.1 -1.7 -0.1
Forced expiratory volume in 1-second (FEV1), Best measure 0.4 1.2 3.3 -1.2 -1.4 -0.7 1.2 -0.3 0.0 0.6 1.8 -1.6 -0.7 0.5 0.9 -0.5 -1.3 -1.5 1.3
Pulse wave Arterial Stiffness index 0.5 0.5 2.7 1.6 -0.2 -0.8 0.3 -0.3 0.0 -0.4 0.2 -0.6 -0.8 -1.2 1.1 0.4 -0.2 -0.9 0.4
Impedance of arm (left) 0.5 2.2 7.9 -0.2 -0.2 -0.6 -2.6 -2.2 0.0 -0.3 -1.0 0.7 0.1 -2.0 -2.8 -1.7 -0.1 0.7 -2.6
Arm fat mass (right) 0.6 2.5 12.5 1.0 -0.2 -1.2 -0.5 -0.7 0.0 -2.2 -3.5 -1.1 -2.2 -3.5 0.1 1.0 -0.3 0.6 -0.1
Trunk predicted mass 0.5 2.7 8.3 0.1 0.4 -0.6 2.5 1.8 0.0 -1.0 -0.7 -2.9 -1.8 -2.0 1.2 2.6 0.3 -0.5 2.8
Standing height 0.3 3.2 21.6 -0.1 0.4 -1.9 0.7 0.4 0.0 -1.2 -1.0 -3.5 -2.2 -4.7 -1.1 1.6 0.2 -0.4 1.1
Length of working week for main job 0.5 0.5 3.4 0.6 0.3 -0.1 0.7 0.8 0.0 -0.5 0.6 -0.8 0.1 -0.4 1.8 1.0 0.5 -0.6 0.7
Exposure to tobacco smoke at home 0.7 0.7 2.6 0.2 0.2 -0.5 -1.0 -0.4 0.0 -0.8 -1.1 -1.6 -0.6 -1.6 -0.9 -0.6 -0.9 0.2 -1.0
Breastfed as a baby 0.5 0.6 2.4 -1.4 -0.8 0.6 0.2 -0.8 0.0 0.6 -0.8 1.2 -0.8 1.5 -0.1 -0.3 -0.9 0.2 0.2
Tense / ‘highly strung’ 0.5 0.8 3.5 -0.2 -1.6 -1.1 0.4 -1.1 0.0 -0.6 -0.9 -0.2 -1.9 0.1 1.0 0.1 -1.4 -0.4 0.5
Seen doctor (GP) for nerves, anxiety, tension or depression 1.3 2.0 6.2 -0.1 -1.3 -2.3 -1.3 -2.5 0.0 -1.5 -0.9 -0.8 -2.3 -1.9 -0.2 -0.3 -1.6 0.7 -1.0
Hair/balding pattern: Pattern 4 0.3 0.8 3.3 -0.8 -1.0 -1.2 -0.7 -0.9 0.0 -0.3 0.1 0.1 -0.0 -0.2 -1.3 -1.5 -1.8 -0.4 -0.6
Birth weight of first child 0.1 0.1 0.6 -0.1 -0.6 -0.1 0.2 -0.6 0.0 -0.4 -0.8 -0.0 -0.6 -0.2 -0.4 0.2 -0.2 -0.3 0.3
Peak expiratory flow (PEF) 0.1 0.3 0.9 -0.4 0.0 0.6 0.1 0.3 0.0 0.3 0.9 -0.2 -0.3 -0.9 -1.0 -0.0 -0.7 0.7 0.1
Pulse wave reflection index 0.5 0.6 2.0 -0.1 -0.7 -1.4 -0.3 -0.6 0.0 0.5 0.5 -0.8 -0.2 0.2 1.3 -1.1 -0.5 -1.4 -0.2
Ever highly irritable/argumentative for 2 days 0.9 1.0 2.9 -0.8 -1.0 -1.7 -0.5 -1.1 0.0 -1.2 -0.5 -0.7 -1.5 -1.5 -1.2 -0.0 -1.6 -0.1 -0.2
Loud music exposure frequency 1.0 1.1 3.5 1.0 0.4 0.1 1.5 1.9 0.0 -0.4 1.6 -0.6 0.1 1.6 1.0 0.7 0.6 -1.3 1.4
Qualifications: O levels/GCSEs or equivalent 0.9 1.5 4.0 0.8 1.2 -0.7 2.0 2.0 0.0 -1.3 -0.6 -0.9 -0.6 0.0 1.3 1.9 0.8 -0.1 2.0
Mouth/teeth dental problems: Bleeding gums 0.6 0.8 2.1 -0.2 1.3 0.8 0.5 1.4 0.0 0.4 0.7 0.3 1.2 1.4 1.5 -0.1 1.0 0.3 0.4
Blood clot in the leg (DVT) 0.5 0.6 2.9 0.4 0.9 1.1 0.2 0.5 0.0 -1.0 -1.3 -0.3 -0.1 -0.1 -0.4 1.1 0.7 1.7 0.2
Medication: Paracetamol 0.9 1.5 4.8 -1.3 -1.5 -0.4 -1.4 -1.7 0.0 1.1 -0.1 1.8 0.6 0.5 -0.6 -2.2 -1.4 -0.7 -1.3
Headache pain in last month 0.9 1.5 5.4 0.6 0.0 -0.5 -2.3 -1.8 0.0 -0.1 -2.0 1.6 -0.6 -0.1 -0.7 -0.9 -0.3 0.8 -2.3
Medication for cholesterol, blood pressure or diabetes 0.2 0.3 1.3 -0.1 -0.3 -0.3 -0.0 -0.2 0.0 -0.4 0.4 -1.1 -0.9 0.7 -0.4 -0.0 -0.7 0.1 -0.1
Glaucoma (self-reported) 1.4 1.6 7.6 -0.2 0.4 2.1 0.6 1.2 0.0 1.8 1.1 1.7 1.4 2.8 -1.1 0.1 0.9 -0.4 0.5
Gout (self-reported) 0.6 0.8 2.4 1.6 1.4 0.9 0.6 1.3 0.0 -0.9 -0.8 0.0 -0.4 -0.6 0.4 1.1 0.8 1.2 0.6
Hypothyroidism/myxoedema (self-reported) 1.8 3.6 10.3 3.2 3.2 1.3 -1.4 1.0 0.0 -1.0 -3.2 1.7 0.5 0.1 -0.3 1.6 2.2 2.7 -1.7
Medication: Amlodipine 0.2 0.3 1.7 -0.7 0.0 -0.2 -0.6 -0.4 0.0 0.1 -0.0 0.0 0.3 -0.8 -1.3 -0.8 -0.7 0.0 -0.5
Medication: Ventolin 100micrograms inhaler 0.6 0.8 5.1 -0.5 0.0 -0.4 -0.8 -0.4 0.0 -0.5 -2.2 1.0 -0.9 -1.2 -0.8 0.3 0.1 1.3 -0.5
Birth weight 0.5 1.2 6.9 0.1 1.3 2.6 0.8 0.7 0.0 -0.5 0.5 1.1 0.3 -0.9 -1.2 1.1 1.1 1.4 0.7
Chronic bronchitis/emphysema (mother) 0.4 0.5 1.5 -0.3 -0.8 -0.4 -0.8 -1.1 0.0 0.7 1.2 0.3 0.5 0.3 -0.1 -1.2 -0.8 -0.5 -0.6
High blood pressure (siblings) 0.6 0.9 3.5 -0.3 0.5 -0.3 -0.5 -0.3 0.0 -1.6 -1.3 0.5 -1.6 -1.9 -1.4 0.0 -0.2 0.7 -0.2
Forced vital capacity (FVC), Best measure 0.2 0.6 2.1 -0.9 -1.1 -0.5 0.0 -1.0 0.0 0.6 1.0 -0.7 -0.7 -0.1 -0.1 -0.8 -1.4 -0.6 0.1
Body fat percentage 0.9 3.5 18.1 1.5 -0.0 -1.4 -1.5 -1.5 0.0 -2.6 -4.2 -0.6 -2.1 -3.9 -0.6 0.5 -0.2 0.9 -1.3
Leg fat percentage (right) 0.6 2.2 13.1 1.5 0.1 -1.0 -0.9 -0.8 0.0 -2.1 -3.6 -0.4 -1.6 -2.9 -0.1 0.8 0.0 0.9 -0.7
Arm fat-free mass (right) 0.5 2.6 9.3 0.3 0.1 -1.5 1.8 1.0 0.0 -1.6 -1.2 -3.0 -2.3 -2.1 1.8 2.0 -0.3 -0.7 2.2
Exposure to tobacco smoke outside home 0.5 0.7 3.7 -0.6 -1.1 -0.3 -0.7 -1.4 0.0 0.4 0.1 -1.0 -0.9 -0.1 -0.3 -0.5 -1.9 -0.5 -0.6
Comparative body size at age 10 0.6 1.8 5.0 -0.5 -1.8 -0.7 -1.7 -2.2 0.0 1.2 1.2 0.7 0.8 1.1 -0.8 -2.2 -1.4 -0.9 -1.7
Number of full brothers 1.3 1.7 4.9 -1.0 -2.0 -1.9 -0.6 -2.2 0.0 0.6 0.8 -1.1 -0.8 0.5 1.7 -1.0 -2.2 -0.6 -0.4
Worry too long after embarrassment 1.1 1.8 6.4 1.5 -0.6 -1.6 -0.4 -0.7 0.0 -1.9 -2.2 -0.8 -2.5 -2.4 0.2 0.8 -0.8 0.9 -0.0
Seen a psychiatrist for nerves, anxiety, tension or depression 1.1 1.4 4.7 0.2 -0.5 -1.6 0.8 -0.4 0.0 -1.9 -1.8 -1.2 -1.8 -2.2 0.4 0.8 -0.8 0.5 1.1
Wheeze or whistling in the chest in last year 0.6 1.1 2.7 0.1 0.8 1.6 -1.5 -0.3 0.0 0.6 -0.7 1.5 1.4 0.9 -0.8 -0.8 1.4 0.7 -1.6
Number of children fathered 0.6 0.7 2.8 -0.2 -1.1 0.8 -0.0 -0.6 0.0 1.7 0.9 1.3 1.1 1.0 -0.1 -0.9 -0.4 -0.7 -0.2
Reason for reducing amount of alcohol drunk: Health precaution 0.6 0.7 1.9 -0.6 -0.4 -1.0 1.3 0.4 0.0 -0.4 0.8 -1.2 -1.3 0.4 0.6 0.3 -0.4 -0.8 1.4
Age at first live birth 0.3 0.6 3.0 0.5 0.9 1.7 0.0 0.4 0.0 -0.7 -0.1 1.4 0.2 0.7 -0.6 0.3 0.8 1.3 -0.1
Pulse wave peak to peak time 0.4 0.4 2.7 -1.6 0.3 0.8 -0.2 0.4 0.0 0.3 -0.1 0.4 0.6 0.7 -1.3 -0.3 0.1 0.9 -0.3
Health satisfaction 0.4 0.6 1.8 -1.4 -0.3 -0.0 1.2 0.6 0.0 -0.4 -0.6 0.9 -0.7 1.0 0.5 0.6 -0.3 0.4 1.4
Shortness of breath walking on level ground 0.1 0.1 0.8 -0.1 -0.4 -0.4 0.3 0.2 0.0 0.1 -0.2 0.3 0.3 0.9 -0.4 0.5 0.2 0.1 0.2
Qualifications: College or University degree 0.3 1.0 4.7 -0.6 -0.4 0.2 2.1 0.7 0.0 0.2 1.3 -0.8 -0.3 0.9 0.8 0.4 -0.1 -1.5 2.2
Eye problems/disorders: None of the above 0.6 0.7 2.0 -1.2 -1.4 -0.4 -0.3 -0.8 0.0 -0.2 -1.2 0.1 -0.3 -1.1 -1.3 -1.1 -0.8 -0.4 -0.3
Mouth/teeth dental problems: Loose teeth 0.7 0.8 2.2 0.3 0.7 0.2 1.5 1.4 0.0 0.2 0.1 -1.2 0.4 -0.5 0.4 1.1 0.9 -1.2 1.5
Emphysema/chronic bronchitis 0.4 0.5 1.7 0.7 0.6 0.7 -0.2 0.6 0.0 -0.1 1.3 -0.1 0.7 1.1 1.2 0.1 1.0 -0.2 -0.4
Medication for pain relief, constipation, heartburn 1.5 2.5 9.5 1.7 1.3 0.6 2.5 1.9 0.0 -1.3 -0.3 -2.0 -1.1 -0.5 1.1 3.1 1.4 0.3 2.4
Neck or shoulder pain in last month 0.2 0.3 2.1 -0.2 0.0 0.3 -0.2 -0.4 0.0 0.3 -1.0 0.8 0.4 1.5 0.9 -0.1 -0.1 0.2 -0.4
Medication: Blood pressure 0.3 0.4 1.3 -0.1 0.4 0.8 -0.9 -0.5 0.0 0.5 0.1 1.1 1.0 -0.4 -0.4 -0.8 1.0 0.3 -0.9
Angina (self-reported) 0.7 0.9 3.9 0.2 -0.7 -0.3 -1.9 -1.7 0.0 1.3 -0.0 0.3 0.2 -0.0 -0.5 -1.1 -0.7 -0.5 -2.0
Migraine (self-reported) 0.8 1.0 3.1 0.5 0.2 0.2 -1.7 -1.0 0.0 0.8 -1.4 1.6 0.3 0.7 -1.2 -0.4 0.5 0.6 -1.8
Medication: Ibuprofen 2.0 2.3 7.8 -0.6 -0.5 0.2 -2.6 -1.4 0.0 1.8 0.9 1.5 1.9 1.8 -1.6 -2.2 0.1 0.0 -2.8
Medication: Allopurinol 0.8 1.1 3.3 1.5 1.8 0.8 0.6 1.6 0.0 -1.1 -0.9 0.0 -0.3 -0.2 0.7 1.3 1.3 1.3 0.5
Medication: Omeprazole 1.3 1.5 5.8 -0.3 0.1 0.0 -2.4 -1.4 0.0 0.7 -0.5 1.3 1.2 -0.7 -1.2 -1.6 -0.0 1.5 -2.4
Medication: Seretide 50 evohaler 0.6 0.7 2.7 0.0 -0.5 0.5 -0.9 -1.1 0.0 1.3 0.7 1.6 0.6 0.7 -0.9 -0.9 0.0 -0.3 -1.0
Mean time to correctly identify matches 0.7 1.4 3.0 1.2 1.7 0.2 1.1 1.7 0.0 -1.2 -1.5 -0.5 -0.4 0.7 1.5 1.6 0.5 1.7 1.0
Heart disease (mother) 0.6 0.7 2.4 0.9 -0.2 -1.5 -0.3 -0.7 0.0 -1.5 -0.5 -0.5 -1.4 -1.4 -0.4 -0.2 -0.5 -0.2 -0.2
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.4 0.5 1.9 -0.7 -0.9 0.3 0.0 -0.6 0.0 0.9 1.1 0.4 0.8 0.1 -0.7 -0.7 -0.5 -1.4 0.0
Whole body fat mass 0.8 3.4 17.3 1.2 -0.1 -1.6 -0.8 -1.1 0.0 -2.6 -3.9 -1.3 -2.4 -4.2 -0.2 0.9 -0.2 0.7 -0.5
Leg fat mass (right) 0.7 2.6 12.4 1.0 -0.4 -1.5 -0.4 -0.9 0.0 -2.3 -3.3 -1.3 -2.3 -3.5 0.1 0.9 -0.4 0.3 -0.1
Arm predicted mass (right) 0.5 2.4 8.4 0.3 0.1 -1.3 1.9 1.1 0.0 -1.4 -1.0 -2.9 -2.1 -2.0 1.5 1.9 -0.1 -1.0 2.3
Pulse rate, automated reading 0.1 0.3 1.0 0.3 0.2 1.0 -0.3 -0.0 0.0 -0.2 0.1 0.8 0.4 0.4 -1.0 -0.3 -0.3 0.8 -0.4
Alcohol intake frequency. 0.3 0.8 3.7 -0.6 -0.5 1.4 -0.8 -0.7 0.0 0.7 -0.4 1.9 0.1 -0.9 -1.7 -0.3 0.4 0.4 -0.7
Comparative height size at age 10 0.5 2.6 19.4 -0.4 -1.0 -1.6 -0.8 -1.4 0.0 -0.5 -0.2 -1.8 -1.6 -4.4 -2.8 -0.1 -1.0 -0.5 -0.6
Number of full sisters 0.9 1.1 2.8 -0.6 -1.6 -1.6 -0.2 -1.4 0.0 0.6 0.4 -1.0 -0.2 -0.1 1.4 -1.1 -1.4 -1.7 -0.2
Suffer from ‘nerves’ 0.6 0.9 3.0 0.5 0.2 -1.0 0.1 -0.6 0.0 -1.7 -1.6 -1.0 -1.7 -0.6 1.0 0.5 -0.8 0.8 0.1
Overall health rating 0.3 0.6 3.8 1.2 0.0 -0.1 0.6 0.2 0.0 -0.8 -1.9 0.7 -0.5 -0.9 0.6 1.2 0.5 -0.0 0.5
Chest pain or discomfort 1.0 1.4 4.2 -0.6 -1.9 -1.9 -1.2 -2.0 0.0 0.7 -0.6 0.6 -1.2 -0.7 -0.1 -1.3 -1.3 -1.3 -0.9
Had major operations 0.2 0.3 1.8 0.2 -0.1 0.6 -0.3 -0.1 0.0 0.6 0.3 0.6 0.1 1.3 0.9 -0.1 -0.1 -0.1 -0.3
Age at last live birth 0.2 0.3 1.2 -0.2 -0.1 0.9 0.1 -0.6 0.0 -1.1 0.6 0.5 -0.7 0.4 -0.2 -0.1 -0.3 0.6 0.1
Family relationship satisfaction 1.0 1.2 5.1 -0.4 1.4 0.9 -0.9 0.4 0.0 -0.8 -2.0 0.1 0.1 0.0 -2.1 0.4 0.6 2.3 -0.8
Leg pain on walking 0.8 0.9 2.8 -1.1 -1.5 -1.7 0.3 -0.9 0.0 -0.6 -1.1 0.3 -1.1 -1.3 -0.3 -0.9 -1.0 -1.0 0.6
Qualifications: NVQ or HND or HNC or equivalent 1.0 1.2 3.8 -1.2 -1.5 -1.1 1.0 -0.3 0.0 0.5 0.6 -0.3 -1.0 0.4 1.9 -0.3 -1.7 -2.0 1.2
Commuting to job workplace: Car/motor vehicle 0.9 1.1 6.1 -0.6 1.3 1.3 -0.7 1.0 0.0 -0.2 -0.3 1.7 0.8 0.6 -0.7 0.4 0.6 2.5 -0.8
Illness, injury, bereavement, stress in last 2 years 1.3 1.5 6.5 -0.8 -1.8 -1.7 -0.8 -2.2 0.0 0.5 -0.1 0.7 -1.0 0.0 -0.5 -1.8 -2.6 -0.4 -0.7
Medication: Aspirin 0.3 0.4 1.7 -1.2 -0.9 -1.3 -0.2 -0.7 0.0 0.3 0.4 0.1 -0.4 -0.7 -0.2 -0.4 -0.5 -0.6 -0.0
Supplements: Vitamin C 0.6 0.7 2.9 -1.0 -0.3 -0.1 -1.0 -1.0 0.0 0.2 0.9 0.3 0.3 0.5 -1.4 -1.7 -0.4 -0.5 -1.0
Knee pain experienced in last month 1.4 2.2 6.4 2.5 1.4 0.3 1.5 1.4 0.0 -2.0 -1.6 -0.8 -1.1 -0.5 1.8 2.2 1.9 0.1 1.4
Hypertension (Self-reported) 0.1 0.4 1.2 -0.2 -0.3 0.1 -0.6 -0.5 0.0 1.1 -0.3 0.9 1.0 -1.1 -0.7 -0.6 0.7 -0.3 -0.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.6 0.7 2.5 0.0 -0.3 0.1 -1.6 -1.0 0.0 1.2 0.4 0.7 0.8 0.1 -0.7 -1.2 -0.4 0.7 -1.6
Illnesses of father: Heart disease 0.8 1.2 3.8 -0.9 0.5 0.4 -1.9 -0.6 0.0 0.1 -0.9 1.7 0.7 -0.0 -1.5 -1.7 0.7 0.6 -1.9
Illnesses of siblings: Diabetes 0.2 0.2 0.7 -0.3 0.5 0.7 0.8 0.3 0.0 -0.3 0.1 -0.3 0.1 0.5 0.8 0.2 -0.2 0.3 0.7
Smoking status: Previous 0.6 0.8 3.6 1.0 0.3 -0.6 -1.8 -1.1 0.0 0.0 0.0 0.4 0.2 -0.2 0.3 -0.8 -1.1 1.4 -1.9
Forced expiratory volume in 1-second (FEV1), predicted 1.1 2.3 10.7 -0.9 -1.4 -2.5 1.6 0.1 0.0 -0.6 0.2 -3.3 -1.5 -1.3 1.0 0.4 -0.5 -2.0 1.8
Whole body fat-free mass 0.5 2.6 8.7 0.1 0.3 -0.7 2.2 1.5 0.0 -1.4 -1.0 -3.0 -2.0 -2.3 1.2 2.3 0.2 -0.4 2.6
Leg fat-free mass (right) 0.4 2.2 7.2 -0.1 -0.2 -0.7 1.9 0.9 0.0 -1.6 -1.2 -2.7 -2.3 -2.2 1.1 1.8 -0.1 -0.4 2.3
Arm fat percentage (left) 0.6 2.5 15.1 1.3 -0.2 -0.9 -1.0 -1.2 0.0 -2.3 -3.9 -0.4 -1.9 -3.0 -0.0 0.7 -0.1 0.9 -0.8
Average weekly red wine intake 0.8 1.1 3.7 1.1 1.4 0.5 1.1 1.4 0.0 -0.1 -1.1 -0.7 1.0 0.1 1.9 0.9 1.9 0.3 1.0
Handedness (chirality/laterality): Left-handed 1.0 1.2 4.6 1.0 1.4 0.3 1.1 1.8 0.0 -1.3 0.1 -2.2 -0.3 -0.1 1.3 1.6 0.7 0.2 1.0
Mood swings 1.0 1.8 5.1 -1.4 -1.0 -2.3 0.4 -0.2 0.0 -1.3 -0.7 -2.1 -2.2 -1.0 1.7 -0.5 -1.9 -0.3 0.8
Loneliness, isolation 1.2 1.6 6.0 0.0 0.0 -1.7 -0.2 -0.4 0.0 -1.8 -1.9 -1.7 -2.5 -1.9 0.3 0.9 -0.9 1.4 0.0
Long-standing illness, disability or infirmity 0.4 0.7 2.3 0.6 0.9 1.1 0.0 0.8 0.0 0.3 -0.3 1.0 0.9 1.5 0.9 0.3 1.4 -0.1 -0.1
Ever had bowel cancer screening 1.5 1.8 6.0 2.2 0.3 0.6 1.7 -0.2 0.0 -1.5 0.1 -2.1 -1.6 -1.4 1.0 2.5 0.7 -0.3 1.5
Diabetes diagnosed by doctor 0.1 0.2 1.0 -0.1 1.0 0.9 0.1 0.6 0.0 0.3 -0.0 0.7 0.3 -0.2 0.5 0.0 0.7 -0.0 0.1
Ever had stillbirth, spontaneous miscarriage or termination 0.7 0.8 2.8 -0.5 -0.3 -0.7 -0.8 -1.0 0.0 0.8 0.9 0.2 0.6 0.6 1.7 -1.6 -0.7 -0.8 -0.8
Friendships satisfaction 0.7 0.9 2.8 -1.0 1.1 1.7 -0.6 0.7 0.0 0.6 0.6 0.2 1.6 1.3 -0.1 -0.3 0.4 1.5 -0.9
Qualifications: nursing, teaching 0.3 0.4 1.3 0.9 0.8 1.2 -0.5 0.0 0.0 0.1 -0.5 0.2 0.4 0.4 -0.9 0.6 1.0 0.7 -0.7
Commuting to job workplace: Walk 1.3 1.4 5.2 -0.3 -1.2 -0.5 2.2 0.2 0.0 0.1 1.2 -0.4 -0.1 1.6 1.2 0.7 0.1 -2.3 2.2
Eye problems/disorders: Cataract 0.9 1.0 2.8 0.8 0.7 -1.3 1.1 0.9 0.0 -1.0 -0.0 -1.1 -1.3 0.2 1.7 1.6 1.0 0.1 1.1
Mouth/teeth dental problems: Mouth ulcers 1.3 2.0 6.2 -0.3 -0.9 0.2 -2.5 -1.5 0.0 1.4 0.7 2.3 0.2 1.2 -1.2 -2.4 -0.6 -0.1 -2.4
Medication for cholesterol 0.6 0.9 2.9 1.1 0.2 -0.4 1.2 0.9 0.0 -0.9 0.2 -1.2 -0.9 0.6 1.7 1.1 0.6 -0.9 1.2
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.8 0.9 2.4 -0.0 0.5 -0.3 1.4 0.7 0.0 -1.5 -1.0 -0.9 -1.5 -0.7 0.2 1.2 -1.2 0.5 1.5
Back pain experienced in last month 0.9 1.3 4.2 -1.0 -1.4 -1.6 -0.1 -1.7 0.0 -0.8 -1.9 -0.9 -2.1 -1.4 0.3 0.1 -1.2 -0.1 0.2
Mineral and other dietary supplements 0.5 0.7 3.4 1.2 0.3 -0.3 0.3 0.5 0.0 -0.8 -1.0 -1.3 -0.2 -1.9 0.3 1.2 0.7 0.3 0.4
Breast cancer (self-reported) 1.1 1.3 3.8 -0.4 -1.8 -1.4 -1.3 -1.9 0.0 0.6 0.4 0.3 -0.3 -1.5 -0.2 -1.6 -1.6 -0.7 -1.2
Asthma (self-reported) 0.6 1.1 5.7 -0.2 -0.2 0.6 -1.4 -0.9 0.0 1.0 -1.3 2.4 0.2 1.0 -1.5 -0.6 0.3 0.7 -1.4
Osteoporosis (self-reported) 0.9 1.2 3.4 0.2 -0.5 0.9 -1.4 -1.5 0.0 1.9 0.5 1.0 0.9 1.6 1.1 -1.1 -0.4 -0.2 -1.6
Osteoarthritis (self-reported) 1.7 2.2 5.1 2.3 1.9 1.1 0.6 1.8 0.0 -0.1 -1.6 2.1 1.0 1.7 1.4 1.9 2.0 0.9 0.4
Medication: Aspirin 0.3 0.4 1.6 -0.7 -0.8 -1.3 -0.6 -1.0 0.0 0.3 0.4 0.2 -0.6 -0.8 -0.5 -0.5 -0.6 -0.6 -0.4
Medication: Gliclazide 0.5 0.5 3.0 -0.5 1.1 1.0 -0.7 0.3 0.0 0.1 0.3 0.1 1.7 -0.5 -0.3 -0.5 0.6 1.0 -0.8
Illnesses of father: None of the above (group 1) 0.3 0.3 1.5 0.5 -0.4 -0.7 -0.4 -0.5 0.0 -0.2 0.2 -1.2 -1.0 -0.1 0.3 0.2 -0.8 0.0 -0.4
Smoking status: Current 1.2 1.8 6.9 1.7 1.1 -0.3 0.6 0.6 0.0 -2.6 -1.6 -1.5 -1.5 -2.3 -0.3 1.5 1.4 0.8 0.6
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.7 1.5 6.7 0.0 -0.0 2.1 -0.3 -0.1 0.0 1.6 2.5 1.0 1.6 2.6 0.2 -0.8 -0.1 -0.4 -0.6
Whole body water mass 0.4 2.5 8.0 0.1 0.3 -0.7 2.1 1.5 0.0 -1.4 -1.1 -2.8 -2.0 -2.2 1.2 2.3 0.2 -0.3 2.5
Leg predicted mass (right) 0.4 2.2 7.1 -0.2 -0.2 -0.6 1.9 1.0 0.0 -1.6 -1.1 -2.7 -2.2 -2.1 1.1 1.8 -0.1 -0.4 2.3
Arm fat mass (left) 0.7 2.7 13.3 1.1 -0.1 -1.1 -0.4 -0.8 0.0 -2.3 -3.6 -1.1 -2.2 -3.6 0.1 1.2 -0.1 0.7 -0.1
Number of self-reported non-cancer illnesses 0.6 1.0 5.5 1.0 0.2 -0.3 -1.5 -0.8 0.0 0.7 -2.4 1.4 0.0 -0.7 -0.5 0.1 0.7 0.6 -1.6
Average weekly champagne plus white wine intake 0.8 1.0 3.1 -1.4 0.4 0.8 1.8 1.7 0.0 0.8 0.4 0.1 0.4 1.7 0.2 0.4 0.0 -0.6 1.8
Miserableness 1.9 3.2 9.9 0.8 0.2 -2.8 -0.0 -0.7 0.0 -3.1 -2.9 -2.2 -2.3 -2.7 0.5 1.2 -1.4 1.5 0.1
Guilty feelings 0.9 1.4 4.4 0.4 0.4 -0.9 1.5 1.0 0.0 -1.9 -0.9 -1.7 -1.2 -2.1 0.2 1.5 0.1 0.3 1.5
Wears glasses or contact lenses 0.6 0.7 2.2 0.4 0.7 1.5 -1.2 -0.3 0.0 0.5 0.2 1.2 1.1 0.3 -1.3 -0.6 -0.1 0.5 -1.3
Ever taken oral contraceptive pill 0.6 0.7 5.6 2.4 0.3 0.3 0.3 0.4 0.0 -0.6 -0.4 -0.0 1.2 -0.3 1.2 0.3 1.0 -0.7 0.1
Hearing aid user 0.6 0.7 2.4 -0.2 -1.0 -1.4 -0.8 -1.0 0.0 0.7 -1.1 -0.8 0.2 -1.5 0.8 -0.4 -0.6 -0.4 -0.6
Mother’s age at death 0.3 0.4 2.1 1.5 0.2 0.8 0.3 -0.1 0.0 -0.1 0.4 1.0 -0.1 1.3 -0.0 0.9 0.3 0.4 0.1
Financial situation satisfaction 0.7 0.8 4.4 -2.1 -1.3 -1.2 -0.4 -0.5 0.0 0.8 0.2 -0.5 -0.4 0.2 -0.6 -1.5 -1.2 -0.7 -0.0
Tinnitus: Yes, now most or all of the time 0.2 0.2 1.8 -0.2 -0.3 0.3 0.3 0.1 0.0 0.2 1.3 -0.7 -0.4 -0.1 -0.0 0.7 -0.7 0.3 0.3
Commuting to job workplace: Public transport 1.3 1.5 4.1 0.0 -2.0 -1.6 -0.3 -1.5 0.0 0.7 1.4 -1.6 -0.9 -1.5 0.6 -0.7 -1.3 -2.0 -0.1
Eye problems/disorders: Glaucoma 1.7 2.0 6.4 0.9 1.4 2.5 -0.7 1.0 0.0 1.5 0.7 2.1 2.0 2.4 -1.3 -0.1 1.5 0.7 -0.9
Medication: Blood pressure 0.2 0.3 1.2 -0.8 0.1 0.8 -0.5 -0.2 0.0 0.8 -0.1 0.1 0.9 -0.3 -1.1 -0.2 -0.2 0.8 -0.5
Pain type(s) experienced in last month: Hip pain 0.4 0.5 1.3 0.9 1.1 0.4 -0.5 0.7 0.0 -1.1 -0.8 -0.2 0.2 -1.1 -0.0 0.7 0.5 0.9 -0.6
Supplements: Fish oil (including cod liver oil) 0.3 0.4 1.3 0.2 0.5 0.3 -0.3 -0.5 0.0 -0.8 -0.7 1.1 -0.8 0.9 -0.4 -0.1 -0.6 1.1 -0.4
High cholesterol (Self-reported) 0.7 1.2 6.5 -0.1 -0.7 -0.9 -0.5 -1.4 0.0 -0.6 -2.5 0.1 -0.7 -2.5 -1.2 0.5 -0.3 0.1 -0.3
Medication: Bendroflumethiazide 0.5 0.8 3.3 -0.4 0.0 -1.3 -0.8 -0.8 0.0 -0.7 -1.8 0.1 -0.6 -1.8 -0.2 -0.8 -0.6 1.0 -0.5
Medication: Paracetamol 1.1 1.7 5.0 -1.2 -1.6 0.2 -1.4 -1.7 0.0 1.5 0.3 2.2 0.7 0.7 -1.3 -2.1 -1.2 -0.7 -1.3
Medication: Lisinopril 0.5 0.7 3.1 0.2 0.7 -0.3 -1.0 -0.2 0.0 0.5 0.0 0.7 1.5 -1.1 -1.8 -0.2 0.3 0.7 -1.1
Medication: Atorvastatin 0.8 1.0 4.4 1.3 1.2 2.1 0.0 0.9 0.0 -0.3 -0.4 -0.0 1.2 -0.5 -1.3 1.2 1.5 0.0 -0.3
Illnesses of father: High blood pressure 0.4 0.5 2.5 1.6 0.8 0.2 -0.2 0.3 0.0 -1.0 -0.4 0.2 0.0 -0.7 0.1 1.0 1.1 0.8 -0.2
Alcohol drinker status: Never 1.1 1.3 5.0 -0.5 -0.1 2.2 0.0 0.4 0.0 2.2 1.2 1.5 1.7 1.2 -1.0 -0.8 1.2 -0.4 -0.1
Ever smoked 0.9 1.5 5.8 2.4 0.2 -1.1 -1.6 -1.1 0.0 -1.7 -1.0 -0.5 -1.3 -2.0 -0.5 -0.0 -0.6 1.0 -1.6
Basal metabolic rate 0.4 2.4 7.5 0.3 0.2 -0.9 1.6 1.0 0.0 -1.7 -1.6 -2.7 -2.2 -2.7 0.9 2.1 0.1 -0.2 2.0
Leg fat percentage (left) 0.6 2.3 14.3 1.7 0.5 -0.8 -1.0 -0.7 0.0 -2.3 -3.8 -0.1 -1.5 -2.6 -0.1 0.9 0.3 1.1 -0.8
Arm fat-free mass (left) 0.5 2.3 6.3 0.4 0.5 -0.8 1.6 1.2 0.0 -1.5 -1.6 -2.5 -2.1 -2.5 1.0 2.2 0.3 0.0 2.0
Number of operations (self-reported) 0.4 0.5 2.5 0.4 0.6 1.2 0.9 0.9 0.0 0.1 -0.1 0.3 0.1 1.6 1.3 0.4 -0.2 -0.1 0.7
Average weekly beer plus cider intake 0.5 0.8 4.0 2.0 0.3 0.2 -1.4 -0.8 0.0 -0.3 -1.1 0.6 -0.8 -0.9 -0.6 0.2 0.2 0.5 -1.4
Irritability 1.1 1.9 4.2 -0.9 0.3 -1.6 -1.6 -1.3 0.0 -1.4 -2.0 -0.1 -2.1 -1.2 -0.5 -1.4 -1.8 1.9 -1.2
Risk taking 0.4 0.5 1.6 0.9 1.3 0.1 0.0 0.2 0.0 -1.0 -0.9 -0.4 -0.6 -0.4 1.3 0.6 -0.6 1.0 -0.0
Ever had prostate specific antigen (PSA) test 0.4 0.5 1.8 0.5 -0.4 -1.2 1.1 0.5 0.0 -0.4 -0.7 -0.4 -0.7 0.2 1.3 0.7 0.1 0.0 1.2
Fractured/broken bones in last 5 years 0.2 0.3 1.1 -0.1 -0.2 -0.1 -1.0 -0.2 0.0 -0.1 -0.1 0.1 -0.1 -0.6 -0.9 -1.0 -0.1 0.2 -0.9
Age started oral contraceptive pill 0.4 0.6 2.5 -1.0 0.5 0.5 -0.5 -0.2 0.0 1.3 1.0 -0.0 1.6 0.9 0.3 -0.6 -0.4 0.1 -0.5
Diastolic blood pressure, automated reading 0.2 0.5 3.6 0.4 0.1 0.2 -0.6 0.0 0.0 -0.7 -1.9 0.5 -1.1 -1.3 -0.2 -0.4 -0.3 0.5 -0.4
Ever depressed for a whole week 1.5 1.9 6.9 0.2 0.1 -2.1 0.3 -0.6 0.0 -2.6 -1.7 -1.1 -2.6 -1.9 -0.6 1.4 -0.3 1.2 0.6
Unable to work because of sickness or disability 0.4 0.6 1.7 -0.2 -1.1 -1.1 -0.6 -1.3 0.0 -0.4 0.1 -0.7 -1.3 -0.3 0.4 -0.9 -0.8 -0.6 -0.4
Commuting to job workplace: Cycle 0.4 0.4 1.8 -1.1 -0.2 -0.2 1.1 0.5 0.0 -0.6 0.2 -0.8 -0.8 -0.4 0.5 0.4 -0.5 -0.3 1.3
Myopia 0.1 0.2 0.6 0.2 0.6 -0.0 -0.1 0.2 0.0 0.1 -0.8 -0.6 0.3 -0.7 0.2 0.3 0.4 0.5 -0.0
Vascular/heart problems diagnosed by doctor 0.3 0.7 1.9 -0.1 0.5 0.2 1.4 1.1 0.0 -0.9 0.6 -1.3 -0.6 1.1 1.0 0.9 -0.3 -0.1 1.3
Cholesterol lowering medication 1.8 2.6 7.5 -0.9 -1.1 -1.2 -1.9 -2.2 0.0 -0.3 -2.5 0.6 -1.4 -2.7 -2.4 -0.8 -1.8 0.8 -1.6
Medication: Omeprazole (e.g. Zanprol) 1.2 1.5 5.9 -0.2 0.4 -0.0 -2.4 -1.2 0.0 0.7 -0.4 0.9 1.2 -0.7 -1.3 -1.6 -0.2 1.5 -2.4
Pain experienced in last month 0.3 0.5 2.0 -0.4 -0.3 0.8 0.5 0.3 0.0 0.6 1.4 -0.8 0.5 -0.4 -1.4 0.2 0.4 -0.5 0.5
Supplements: Calcium 1.5 1.6 5.4 -1.0 -1.5 -0.0 -1.7 -2.2 0.0 1.0 1.3 -0.1 0.2 1.0 -0.4 -2.3 -0.6 -1.4 -1.7
Basal cell carcinoma (self-reported) 0.3 0.3 1.5 0.9 0.3 0.4 -0.0 0.2 0.0 0.6 0.5 0.7 0.7 0.3 -1.2 0.5 0.8 -0.4 -0.3
Heart attack/myocardial infarction (self-reported) 0.7 0.9 6.0 0.2 0.0 -0.2 -0.0 0.0 0.0 -1.1 -2.4 0.1 -0.9 -0.9 -1.3 1.1 -0.1 1.5 0.1
Deep venous thrombosis (DVT) (self-reported) 0.6 0.7 3.3 0.6 1.1 1.2 0.1 0.7 0.0 -0.9 -1.3 0.1 0.1 0.1 -0.2 1.1 1.0 1.8 0.1
Heart disease (siblings) 0.5 0.7 2.7 -0.4 -1.3 0.4 0.3 -0.5 0.0 1.6 1.1 0.5 0.9 1.0 0.2 -0.4 -0.2 -1.4 0.2
Alcohol drinker status: Previous 1.2 1.3 4.2 1.9 1.5 2.0 0.1 0.7 0.0 -0.3 -0.9 1.7 0.4 0.8 0.3 1.1 2.0 1.1 -0.1
Pack years of smoking 0.4 0.6 3.3 -0.8 0.1 0.1 0.8 0.0 0.0 -0.8 -1.8 -0.7 -0.2 -0.7 -1.2 0.9 0.1 0.6 0.8
Impedance of whole body 0.4 2.3 8.5 0.1 0.0 -0.8 -2.7 -1.9 0.0 -0.1 -0.8 0.8 0.4 -1.9 -2.9 -1.6 0.0 0.6 -2.9
Leg fat mass (left) 0.6 2.4 11.1 1.1 -0.2 -1.3 -0.5 -0.9 0.0 -2.3 -3.3 -1.1 -2.2 -3.3 0.0 1.0 -0.2 0.5 -0.2
Arm predicted mass (left) 0.5 2.3 7.6 0.2 0.5 -0.8 1.7 1.4 0.0 -1.5 -1.4 -2.8 -2.2 -2.4 1.1 2.1 0.1 -0.0 2.0