Best TWAS P=6.95e-65 · Best GWAS P=1.53e-85 conditioned to NaN
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | PPA2 | 0.08 | 0.03 | bslmm | 429 | 0.04 | 2.2e-05 | -12.25 | -14.0 | 1.1e-44 | -0.55 | 0.18 | 0.74 | TRUE |
| 2 | GTEx | Adipose Subcutaneous | PPA2 | 0.15 | 0.02 | enet | 36 | 0.06 | 7.0e-06 | 10.69 | -8.0 | 1.3e-15 | -0.44 | 0.23 | 0.24 | TRUE |
| 3 | GTEx | Adipose Visceral Omentum | PPA2 | 0.15 | 0.04 | lasso | 6 | 0.05 | 9.1e-04 | 9.60 | -6.0 | 2.6e-09 | -0.38 | 0.14 | 0.09 | FALSE |
| 4 | GTEx | Artery Aorta | PPA2 | 0.11 | -0.01 | enet | 24 | 0.01 | 1.6e-01 | -17.55 | -11.1 | 1.3e-28 | -0.49 | 0.06 | 0.40 | FALSE |
| 5 | GTEx | Artery Tibial | PPA2 | 0.08 | 0.02 | enet | 19 | 0.04 | 5.0e-04 | -12.65 | -5.3 | 1.4e-07 | -0.38 | 0.18 | 0.16 | FALSE |
| 6 | GTEx | Brain Cerebellum | PPA2 | 0.22 | 0.01 | lasso | 4 | 0.03 | 3.7e-02 | -12.65 | -10.0 | 1.5e-23 | -0.44 | 0.09 | 0.10 | FALSE |
| 7 | GTEx | Brain Cortex | PPA2 | 0.14 | 0.09 | lasso | 9 | 0.09 | 1.6e-03 | -14.03 | -14.2 | 4.7e-46 | -0.54 | 0.04 | 0.73 | TRUE |
| 8 | GTEx | Breast Mammary Tissue | PPA2 | 0.26 | 0.06 | lasso | 5 | 0.04 | 2.7e-03 | 0.59 | -5.5 | 3.6e-08 | -0.28 | 0.14 | 0.20 | FALSE |
| 9 | GTEx | Breast Mammary Tissue (Female) | PPA2 | 0.15 | 0.02 | lasso | 4 | 0.00 | 2.8e-01 | -8.02 | -5.2 | 2.5e-07 | -0.23 | 0.05 | 0.12 | TRUE |
| 10 | GTEx | Cells Transformed fibroblasts | PPA2 | 0.11 | 0.03 | lasso | 3 | 0.01 | 6.5e-02 | -9.92 | -11.4 | 6.5e-30 | -0.39 | 0.40 | 0.15 | FALSE |
| 11 | GTEx | Esophagus Gastroesophageal Junction | PPA2 | 0.29 | 0.15 | lasso | 5 | 0.14 | 8.8e-06 | -17.55 | -17.0 | 7.0e-65 | -0.64 | 0.03 | 0.95 | TRUE |
| 12 | GTEx | Esophagus Mucosa | PPA2 | 0.18 | 0.06 | enet | 14 | 0.12 | 2.5e-08 | 18.02 | -17.0 | 1.9e-64 | -0.76 | 0.07 | 0.93 | TRUE |
| 13 | GTEx | Heart Atrial Appendage | PPA2 | 0.15 | 0.05 | lasso | 7 | 0.06 | 7.4e-04 | -14.76 | -8.5 | 2.6e-17 | -0.29 | 0.22 | 0.43 | TRUE |
| 14 | GTEx | Lung | PPA2 | 0.09 | 0.02 | enet | 16 | 0.03 | 1.4e-03 | 2.83 | -8.4 | 3.8e-17 | -0.46 | 0.20 | 0.31 | FALSE |
| 15 | GTEx | Muscle Skeletal | PPA2 | 0.19 | 0.06 | enet | 28 | 0.11 | 8.7e-11 | -13.76 | -10.5 | 1.1e-25 | -0.41 | 0.93 | 0.06 | FALSE |
| 16 | GTEx | Nerve Tibial | PPA2 | 0.13 | 0.07 | enet | 23 | 0.07 | 2.1e-05 | -12.65 | -12.3 | 5.1e-35 | -0.45 | 0.38 | 0.42 | FALSE |
| 17 | GTEx | Ovary | PPA2 | 0.18 | 0.10 | lasso | 3 | 0.14 | 2.2e-04 | -12.65 | -15.1 | 2.3e-51 | -0.58 | 0.05 | 0.73 | TRUE |
| 18 | GTEx | Skin Sun Exposed Lower leg | PPA2 | 0.09 | 0.07 | lasso | 3 | 0.04 | 4.3e-04 | 9.60 | -9.7 | 3.4e-22 | -0.46 | 0.65 | 0.05 | FALSE |
| 19 | GTEx | Skin Sun Exposed Lower leg | TET2 | 0.09 | 0.01 | enet | 18 | 0.02 | 3.6e-03 | -18.14 | -12.1 | 9.5e-34 | -0.49 | 0.01 | 0.94 | TRUE |
| 20 | GTEx | Thyroid | PPA2 | 0.22 | 0.01 | enet | 18 | 0.12 | 2.9e-09 | 10.57 | -9.1 | 1.1e-19 | -0.53 | 0.74 | 0.07 | FALSE |
| 21 | METSIM | Adipose | PPA2 | 0.08 | 0.05 | lasso | 2 | 0.04 | 3.7e-07 | 9.60 | 10.1 | 5.7e-24 | 0.46 | 0.96 | 0.01 | TRUE |
| 22 | ROSMAP | Brain Pre-frontal Cortex | PPA2 | 0.32 | 0.38 | lasso | 2 | 0.38 | 1.1e-51 | 9.60 | -10.5 | 6.0e-26 | -0.48 | 1.00 | 0.00 | FALSE |
| 23 | YFS | Blood | PPA2 | 0.22 | 0.05 | lasso | 19 | 0.12 | 9.7e-38 | -6.23 | 8.8 | 9.3e-19 | 0.33 | 1.00 | 0.00 | FALSE |
| 24 | The Cancer Genome Atlas | Breast Invasive Carcinoma | ARHGEF38 | 0.02 | 0.01 | blup | 82 | 0.01 | 2.0e-03 | -3.18 | -7.7 | 1.5e-14 | -0.17 | 0.01 | 0.06 | TRUE |
| 25 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | PPA2 | 0.11 | 0.03 | blup | 84 | 0.03 | 4.7e-04 | -12.65 | -8.0 | 1.5e-15 | -0.34 | 0.18 | 0.68 | TRUE |
| 26 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | PPA2 | 0.29 | 0.01 | blup | 84 | 0.10 | 4.3e-06 | -8.02 | -6.0 | 1.9e-09 | -0.31 | 0.13 | 0.12 | FALSE |
| 27 | The Cancer Genome Atlas | Brain Lower Grade Glioma | PPA2 | 0.11 | 0.02 | blup | 84 | 0.02 | 1.5e-03 | -8.02 | -6.3 | 3.9e-10 | -0.30 | 0.48 | 0.04 | TRUE |
| 28 | The Cancer Genome Atlas | Thyroid Carcinoma | PPA2 | 0.04 | 0.02 | blup | 84 | 0.04 | 6.1e-05 | -13.76 | -12.2 | 5.0e-34 | -0.44 | 0.14 | 0.65 | FALSE |