Best TWAS P=1.03e-18 · Best GWAS P=1.9e-25 conditioned to 4e-05
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Cells Transformed fibroblasts | NLN | 0.17 | 0.03 | lasso | 9 | 0.06 | 2.3e-05 | 4.3 | 5.2 | 2.2e-07 | -0.11 | 0.95 | 0.00 | FALSE |
| 2 | METSIM | Adipose | NLN | 0.06 | 0.03 | enet | 15 | 0.03 | 6.4e-06 | -3.9 | 5.1 | 2.7e-07 | -0.13 | 0.98 | 0.01 | FALSE |
| 3 | METSIM | Adipose | SGTB | 0.03 | 0.00 | bslmm | 384 | 0.01 | 4.7e-03 | -4.2 | 6.5 | 8.1e-11 | -0.12 | 0.19 | 0.21 | TRUE |
| 4 | The Cancer Genome Atlas | Breast Invasive Carcinoma | ADAMTS6 | 0.03 | 0.02 | lasso | 4 | 0.01 | 3.4e-03 | -9.3 | 8.8 | 1.0e-18 | -0.87 | 0.03 | 0.96 | TRUE |
| 5 | The Cancer Genome Atlas | Breast Invasive Carcinoma | NLN | 0.04 | 0.02 | lasso | 7 | 0.02 | 3.2e-05 | 4.9 | 5.6 | 2.2e-08 | -0.15 | 0.01 | 0.95 | FALSE |