TWAS hub - ADAMTS6

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	ROSMAP	Brain Pre-frontal Cortex	0.0296	0.0167	0.0290	-0.002	0.002	0.006	0.002	-0.001	0.86000	0.1500	0.047	0.15	0.5500
2	TCGA	Breast Invasive Carcinoma	0.0321	0.0140	0.0011	0.016	0.010	0.006	NA	0.010	0.00028	0.0037	0.020	NA	0.0034

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Number of full sisters	9.1	11.1	18.4	1.9	4.3
Forced vital capacity (FVC), Best measure	7.4	27.1	33.5	4.5	5.8
Forced vital capacity (FVC)	6.7	25.7	32.5	4.3	5.7
Forced expiratory volume in 1-second (FEV1), predicted	6.1	12.7	17.1	2.9	4.1
Forced expiratory volume in 1-second (FEV1), Best measure	5.5	17.5	23.9	3.3	4.9
Forced expiratory volume in 1-second (FEV1)	5.0	16.9	24.0	3.1	4.9
Comparative body size at age 10	4.8	13.3	20.9	-4.6	-2.4
Medication: Ramipril	4.7	6.0	9.3	-3.0	-1.7
Medication: Seretide 50 evohaler	4.6	5.3	6.0	2.2	2.5
Hair/balding pattern: Pattern 2	4.2	5.3	10.4	0.5	3.2
Age started oral contraceptive pill	3.7	4.7	9.3	-3.0	-0.3
Had other major operations	3.6	4.4	7.2	-1.3	-2.7
Hair/balding pattern: Pattern 3	3.6	5.4	5.6	-2.3	-2.4
Age when periods started (menarche)	3.4	8.3	8.6	2.8	2.9
Lung FVC	3.2	16.1	20.0	4.5	3.5
Diabetes (father)	3.2	4.0	4.9	1.7	2.2
Pulse wave Arterial Stiffness index	3.2	3.7	6.5	2.5	1.0
Eye problems/disorders: Cataract	3.2	3.7	4.6	-1.7	-2.1
Pack years of smoking	3.1	4.5	6.9	-1.4	-2.6
Smoking status: Previous	3.0	4.6	5.3	2.3	2.0
Length of working week for main job	2.7	3.0	5.4	-2.3	0.8
Pulse wave peak to peak time	2.7	3.2	6.1	-2.5	-0.6
Wears glasses or contact lenses	2.7	3.1	5.3	-2.3	-1.0
Risk taking	2.7	4.0	6.2	2.5	1.4
Impedance of arm (right)	2.5	11.8	12.4	3.5	3.4
Impedance of arm (left)	2.5	11.6	12.3	3.3	3.5
Long-standing illness, disability or infirmity	2.5	3.8	4.2	2.0	1.9
Coronary Artery Disease (CAD)	2.4	2.8	3.5	-1.9	-1.5
Standing height	2.4	23.9	42.7	2.3	6.5
Breast Cancer	2.3	5.5	7.1	2.0	2.7
Height	2.3	44.6	78.0	3.3	8.8
Asthma	2.3	4.5	8.7	2.9	0.6
Prospective memory result	2.3	2.8	5.0	-0.7	-2.2
Illnesses of mother	2.3	2.8	3.7	1.9	1.4
Tinnitus: Yes, now most or all of the time	2.3	2.6	4.9	0.6	-2.2
Pulse rate	2.2	3.7	6.3	2.5	1.1
Asthma (self-reported)	2.2	4.4	8.6	2.9	0.2
Alcohol intake versus 10 years previously	2.1	3.1	4.5	1.3	2.1
Shortness of breath walking on level ground	2.1	2.6	4.5	0.8	2.1
Wheeze or whistling in the chest in last year	2.0	3.7	6.2	2.5	1.0
Supplements: Vitamin C	2.0	2.3	3.6	1.9	1.0
Friendships satisfaction	2.0	2.5	3.3	-1.3	1.8
Illnesses of father: None of the above (group 1)	2.0	2.4	4.1	-0.9	-2.0
Type 2 Diabetes (T2D) (2012)	1.9	2.1	2.6	1.6	1.3
Medication for hormone replacement therapy	1.9	2.1	3.8	-0.6	1.9
Taking other prescription medications	1.9	3.0	3.7	1.9	1.5
Qualifications: CSEs or equivalent	1.9	2.5	3.1	1.4	1.8
Past tobacco smoking	1.9	3.6	3.9	-1.8	-2.0
Medication: Lisinopril	1.9	2.5	4.9	2.2	-0.3
Eye problems/disorders: None of the above	1.8	2.1	2.7	1.6	1.2
Mean time to correctly identify matches	1.8	3.4	6.6	-0.4	-2.6
Comparative height size at age 10	1.8	9.7	19.2	0.6	4.4
Schizophrenia vs Biploar Disorder	1.7	2.2	3.6	-1.0	-1.9
Alcohol usually taken with meals	1.7	2.7	3.8	-2.0	-1.3
Illnesses of father: Heart disease	1.7	2.3	4.1	-2.0	0.7
Verbal and Numeric Reasoning (VNR)	1.6	3.9	5.4	1.5	2.3
Lung FEV1/FVC ratio	1.6	8.1	11.1	-3.3	-2.3
Breastfed as a baby	1.6	1.9	3.9	-0.0	-2.0
Medication: Ventolin 100micrograms inhaler	1.6	2.1	4.2	2.0	0.2
High blood pressure (siblings)	1.6	2.3	4.6	-0.2	-2.2
Average weekly red wine intake	1.6	2.4	3.6	-1.9	-1.1
Pack years adult smoking proportion	1.5	2.2	3.3	-1.1	-1.8
Birth weight	1.5	3.2	3.3	1.8	1.7
Reason for reducing amount of alcohol drunk: Health precaution	1.5	1.7	3.1	-1.8	-0.6
Medication for cholesterol	1.5	2.3	4.4	0.5	-2.1
Lupus	1.4	2.1	3.8	0.6	2.0
Waist Hip Ratio (WHR)	1.4	6.3	10.8	1.4	-3.3
Heel bone mineral density (BMD) T-score, automated (left)	1.4	3.2	6.2	-0.4	2.5
Heel bone mineral density (BMD) T-score, automated (right)	1.4	3.1	6.2	-0.3	2.5
Health satisfaction	1.4	1.9	3.3	-0.7	1.8
Impedance of whole body	1.4	7.1	8.0	2.8	2.5
Heel T-Score	1.3	10.6	21.3	0.1	4.6
Respiratory disease	1.3	2.9	5.7	2.4	0.1
Diabetes (self-reported)	1.3	2.0	3.9	-2.0	-0.0
Commuting to job workplace: Car/motor vehicle	1.3	1.5	3.1	1.8	0.1
Trunk fat mass	1.2	5.0	10.0	-0.0	3.2
Illnesses of siblings	1.2	1.7	3.4	-0.2	1.8
Hypothyroidism/myxoedema (self-reported)	1.2	2.4	4.8	-2.2	-0.1
Number of full brothers	1.2	1.5	2.7	1.6	-0.6
LDL Cholesterol	1.1	1.8	2.0	-1.4	-1.2
Type 2 Diabetes (T2D) (2018)	1.1	2.2	3.6	-1.9	0.8
Number of treatments/medications taken	1.1	2.0	2.0	1.4	1.4
Leg fat-free mass (left)	1.1	6.0	11.8	-0.3	3.4
Trunk fat percentage	1.1	4.3	8.5	0.1	2.9
Sitting height	1.1	7.6	14.8	0.6	3.9
Leg predicted mass (left)	1.1	5.9	11.8	-0.4	3.4
Number of incorrect matches in round	1.1	1.9	3.6	0.4	1.9
Leg fat-free mass (right)	1.1	6.0	11.8	-0.4	3.4
Loneliness, isolation	1.1	1.6	1.8	1.2	1.3
Diabetes diagnosed by doctor	1.1	1.8	3.7	-1.9	-0.2
Leg predicted mass (right)	1.1	6.1	12.0	-0.3	3.5
Reaction Time	1.0	1.8	3.5	-0.4	-1.9
Medication: Atenolol	1.0	1.2	2.4	-1.5	0.3
Medication: Simvastatin	1.0	1.5	2.9	-1.7	0.3
Hair/balding pattern: Pattern 4	1.0	2.3	3.3	-1.2	-1.8
Seen a psychiatrist for nerves, anxiety, tension or depression	1.0	1.4	2.6	-0.4	1.6
Family relationship satisfaction	1.0	1.3	2.4	-1.6	0.3
Illness, injury, bereavement, stress in last 2 years	1.0	1.2	1.8	-1.3	-0.9
Osteoarthritis (self-reported)	1.0	1.3	1.5	-1.2	-1.0
Supplements: Calcium	1.0	1.1	2.1	0.4	1.4
Alzheimer’s Disease (including proxy)	0.9	1.3	1.9	-0.9	-1.4
Systolic blood pressure, automated reading	0.9	2.5	3.5	1.2	-1.9
Hayfever/allergic rhinitis (self-reported)	0.9	1.2	2.2	0.3	1.5
Qualifications: NVQ or HND or HNC or equivalent	0.9	1.1	1.8	-1.3	-0.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.9	1.9	2.5	1.1	1.6
Eye problems/disorders: Diabetes related eye disease	0.8	0.9	1.1	-0.8	-1.1
Supplements: Zinc	0.8	0.9	1.5	1.2	0.6
High blood pressure (mother)	0.8	1.1	2.2	-1.5	-0.4
Hip circumference	0.8	3.5	6.6	-0.6	2.6
Qualifications: A levels/AS levels or equivalent	0.8	1.9	3.3	-0.6	1.8
Lung cancer (father)	0.8	0.9	1.9	-0.2	-1.4
Mouth/teeth dental problems: Bleeding gums	0.8	1.0	1.9	-1.4	-0.4
Glaucoma (self-reported)	0.8	0.9	1.4	1.2	0.6
Medication: Blood pressure	0.8	1.4	2.6	-0.5	-1.6
Whole body fat-free mass	0.8	4.5	8.4	-0.7	2.9
Medication: Gliclazide	0.8	0.9	1.4	-0.7	-1.2
Hearing aid user	0.8	0.9	1.4	-0.6	-1.2
Ever smoked	0.8	1.4	1.4	1.1	1.2
Basal metabolic rate	0.8	4.5	8.6	-0.7	2.9
Irritability	0.8	1.3	2.1	1.4	0.7
Medication: Omeprazole (e.g. Zanprol)	0.8	1.0	1.9	-0.2	1.4
Intelligence (Savage-Jansen 2018)	0.7	2.3	4.3	0.4	2.1
Alzheimer’s Disease (in father)	0.7	0.7	1.0	-0.7	-1.0
Systolic Blood Pressure	0.7	3.4	6.1	2.5	-0.9
Diabetes (mother)	0.7	0.9	1.7	-0.4	-1.3
Heart attack	0.7	0.9	1.5	-0.5	-1.2
Weight	0.7	3.5	6.6	-0.6	2.6
Worrier / anxious feelings	0.7	1.4	2.6	-0.4	1.6
Exposure to tobacco smoke at home	0.7	0.8	0.9	-1.0	-0.8
Peak expiratory flow (PEF)	0.7	1.7	2.5	0.9	1.6
Loud music exposure frequency	0.7	0.8	0.9	-1.0	0.8
Number of children fathered	0.7	0.8	1.1	-0.7	-1.1
Migraine (self-reported)	0.7	0.9	1.7	0.4	1.3
Whole body fat mass	0.7	3.0	5.9	-0.2	2.4
Knee pain experienced in last month	0.7	1.0	1.8	0.6	-1.3
Whole body water mass	0.7	4.2	7.8	-0.8	2.8
Medication: Blood pressure	0.7	1.3	2.3	0.5	1.5
Ovarian Cancer	0.6	0.9	1.1	-1.0	-0.8
Bipolar Disorder (2011)	0.6	0.6	1.0	1.0	0.4
HDL Cholesterol	0.6	1.0	1.2	1.1	0.9
Impedance of leg (right)	0.6	2.7	5.2	2.3	0.4
Frequency of unenthusiasm / disinterest in last 2 weeks	0.6	0.8	1.2	-0.6	-1.1
Relative age voice broke	0.6	1.0	1.6	-0.6	-1.3
Tinnitus: Yes, but not now, but have in the past	0.6	0.7	1.0	0.6	1.0
Serious illness, injury or assault to yourself	0.6	0.7	1.3	-0.3	-1.1
Supplements: Glucosamine	0.6	0.8	1.3	1.1	0.5
Had menopause	0.6	0.7	0.9	-0.9	-0.7
Qualifications: None of the above	0.6	1.3	2.2	0.7	-1.5
Falls in the last year	0.6	0.8	1.5	-0.2	-1.2
Arm fat mass (right)	0.6	2.3	4.3	-0.5	2.1
Ever highly irritable/argumentative for 2 days	0.6	0.7	1.4	0.3	1.2
Headache pain in last month	0.6	1.0	1.6	-1.3	0.6
Arm fat-free mass (right)	0.6	3.0	4.6	-1.2	2.1
Mouth/teeth dental problems: Loose teeth	0.6	0.7	1.0	-1.0	-0.6
Angina (self-reported)	0.6	0.9	1.1	-1.1	-0.8
Arm predicted mass (right)	0.6	3.2	4.3	-1.4	2.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.6	0.7	0.8	-0.7	-0.9
Arm fat percentage (left)	0.6	2.5	5.0	0.1	2.2
Arm fat mass (left)	0.6	2.5	4.7	-0.5	2.2
Ever taken oral contraceptive pill	0.6	0.7	1.3	0.2	1.1
Arm fat-free mass (left)	0.6	2.9	3.5	-1.6	1.9
Average weekly beer plus cider intake	0.6	0.9	1.8	-0.0	-1.3
Pain experienced in last month	0.6	1.1	1.8	-1.4	-0.5
Alcohol drinker status: Previous	0.6	0.7	1.2	0.5	-1.1
Arm predicted mass (left)	0.6	2.8	4.2	-1.2	2.0
Blood White Count	0.5	3.7	6.6	0.9	-2.6
Chronotype (morning person)	0.5	1.2	1.8	-0.8	-1.4
Tanning	0.5	5.8	10.9	0.9	-3.3
Average weekly spirits intake	0.5	0.6	0.9	-0.6	-0.9
Frequency of depressed mood in last 2 weeks	0.5	0.7	1.4	0.2	1.2
Other serious medical condition/disability diagnosed by doctor	0.5	0.7	1.4	-0.1	1.2
Ever used hormone-replacement therapy (HRT)	0.5	0.7	1.4	0.1	1.2
Angina	0.5	0.7	0.8	-0.9	-0.8
Impedance of leg (left)	0.5	2.3	4.3	2.1	0.4
Arm fat percentage (right)	0.5	1.9	3.9	0.0	2.0
Trunk fat-free mass	0.5	3.0	5.3	-0.8	2.3
Happiness	0.5	0.6	1.1	-1.0	0.4
Depression (self-reported)	0.5	0.6	1.2	-0.1	-1.1
Trunk predicted mass	0.5	2.8	5.0	-0.8	2.2
Chronic bronchitis/emphysema (mother)	0.5	0.6	0.8	0.9	-0.5
Body fat percentage	0.5	1.8	3.6	-0.1	1.9
Neck or shoulder pain in last month	0.5	0.8	0.9	-0.9	-0.8
Medication: Omeprazole	0.5	0.6	1.1	0.2	1.1
Medication: Aspirin	0.5	0.7	1.1	-1.1	-0.4
Guilty feelings	0.5	0.8	1.4	1.2	0.5
Mother’s age at death	0.5	0.7	1.3	-1.1	-0.2
Unable to work because of sickness or disability	0.5	0.7	0.8	0.9	-0.7
Commuting to job workplace: Cycle	0.5	0.6	0.8	-0.9	0.7
Major Depression (MDD)	0.4	0.5	1.0	1.0	0.0
BMI	0.4	2.3	4.0	-2.0	0.8
Medication: Metformin	0.4	0.5	0.8	-0.9	0.4
Multivitamins +/- minerals	0.4	0.5	1.0	0.1	1.0
Diverticular disease/diverticulitis (self-reported)	0.4	0.4	0.9	-0.9	0.2
Ever unenthusiastic/disinterested for a whole week	0.4	0.5	0.7	0.6	0.8
Mouth/teeth dental problems	0.4	0.6	0.8	0.9	0.6
Qualifications: O levels/GCSEs or equivalent	0.4	0.7	1.3	-0.1	1.1
Medication: Paracetamol	0.4	0.6	1.2	-0.2	1.1
Exposure to tobacco smoke outside home	0.4	0.6	0.9	-0.5	-0.9
Worry too long after embarrassment	0.4	0.7	1.1	0.5	1.0
Had major operations	0.4	0.4	0.8	0.2	0.9
Medication: Aspirin	0.4	0.5	0.9	-1.0	-0.4
Ever had bowel cancer screening	0.4	0.4	0.5	-0.7	-0.6
Breast cancer (self-reported)	0.4	0.5	0.5	0.7	-0.7
Osteoporosis (self-reported)	0.4	0.5	1.1	-1.0	0.1
Number of self-reported non-cancer illnesses	0.4	0.7	1.4	1.2	-0.0
Miserableness	0.4	0.8	1.1	1.0	-0.7
Commuting to job workplace: Public transport	0.4	0.5	0.6	-0.8	-0.6
Medication: Bendroflumethiazide	0.4	0.6	0.6	0.8	0.8
Ever depressed for a whole week	0.4	0.5	0.6	0.6	0.8
Basal cell carcinoma (self-reported)	0.4	0.5	0.8	-0.9	0.3
Heart attack/myocardial infarction (self-reported)	0.4	0.6	0.9	-0.5	-0.9
Heart disease (siblings)	0.4	0.5	0.8	0.4	0.9
Bipolar Disorder (2018)	0.3	0.5	0.8	-0.5	-0.9
Alzheimer’s Disease (in mother)	0.3	0.3	0.7	-0.8	-0.0
Prostate Cancer	0.3	0.5	0.9	-0.1	0.9
Mean Putamen Volume	0.3	0.4	0.7	0.2	-0.8
Fasting Glucose	0.3	0.3	0.6	-0.3	-0.8
Triglycerides	0.3	0.6	0.6	-0.8	0.7
Hypothyroidism (self reported)	0.3	0.7	1.0	-1.0	0.7
Sensitivity / hurt feelings	0.3	0.5	0.9	-0.2	0.9
Severe depression (siblings)	0.3	0.4	0.4	-0.6	0.6
Townsend deprivation index at recruitment	0.3	0.5	0.7	0.5	0.8
Body mass index (BMI)	0.3	1.4	2.8	-1.7	-0.2
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.4	0.5	-0.6	0.7
Financial difficulties in last 2 years	0.3	0.5	0.9	0.9	0.1
Allergy	0.3	0.7	0.8	-0.8	-0.9
Pain all over the body in last month	0.3	0.4	0.5	0.7	0.5
Neuroticism score	0.3	0.6	0.6	0.8	0.8
Father’s age at death	0.3	0.4	0.8	-0.1	0.9
Number of live births	0.3	0.4	0.5	-0.7	-0.6
Medication: Lansoprazole	0.3	0.3	0.6	-0.1	-0.8
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.4	0.9	-0.9	-0.1
Birth weight of first child	0.3	0.6	1.0	-0.5	1.0
Medication for cholesterol, blood pressure or diabetes	0.3	0.5	0.7	-0.6	0.9
Pulse rate, automated reading	0.3	1.0	1.8	1.3	-0.6
Leg pain on walking	0.3	0.4	0.5	0.5	0.7
Qualifications: nursing, teaching	0.3	0.5	0.5	0.7	0.7
Commuting to job workplace: Walk	0.3	0.3	0.5	-0.7	-0.0
Back pain experienced in last month	0.3	0.4	0.6	0.8	0.3
Eye problems/disorders: Glaucoma	0.3	0.4	0.5	0.7	0.5
Supplements: Fish oil (including cod liver oil)	0.3	0.3	0.6	0.3	0.8
High cholesterol (Self-reported)	0.3	0.5	1.0	-1.0	0.2
Medication: Paracetamol	0.3	0.5	1.1	0.0	1.0
Ever had prostate specific antigen (PSA) test	0.3	0.4	0.6	-0.7	-0.4
Bipolar Disorder or Schizophrenia	0.2	0.6	0.8	-0.9	-0.7
Crohns Disease (2012)	0.2	0.3	0.5	-0.3	-0.7
HbA1C	0.2	0.2	0.4	-0.2	-0.6
Neuroticism (2016)	0.2	0.3	0.6	0.8	0.0
Schizophrenia (2014)	0.2	0.3	0.4	0.5	-0.7
Blood Red Count	0.2	1.7	2.2	1.5	1.1
Smoking Status	0.2	0.4	0.6	0.4	0.8
Vitamin and mineral supplements	0.2	0.3	0.5	-0.3	-0.7
Current tobacco smoking	0.2	0.4	0.6	0.4	-0.8
Average weekly fortified wine intake	0.2	0.2	0.3	-0.5	-0.3
Fed-up feelings	0.2	0.3	0.6	0.8	0.3
Bilateral oophorectomy (both ovaries removed)	0.2	0.2	0.3	-0.3	0.5
High blood pressure	0.2	0.5	1.0	-0.1	-1.0
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.2	0.4	-0.4	-0.6
Mouth/teeth dental problems: Dentures	0.2	0.3	0.5	0.7	0.3
Medication: Ibuprofen (e.g. Nurofen)	0.2	0.3	0.5	0.2	0.7
Medication: Cholesterol lowering	0.2	0.4	0.7	-0.2	-0.8
Tense / ‘highly strung’	0.2	0.4	0.6	0.8	-0.4
Pulse wave reflection index	0.2	0.2	0.2	0.5	-0.4
Gout (self-reported)	0.2	0.3	0.5	0.3	0.7
Medication for pain relief, constipation, heartburn	0.2	0.4	0.7	0.0	-0.8
Medication: Allopurinol	0.2	0.2	0.4	0.3	0.6
Heart disease (mother)	0.2	0.3	0.5	-0.7	-0.2
Leg fat mass (right)	0.2	0.7	1.0	-0.7	1.0
Alcohol intake frequency.	0.2	0.5	0.8	-0.3	-0.9
Chest pain or discomfort	0.2	0.3	0.4	-0.3	0.6
Hypertension (Self-reported)	0.2	0.4	0.9	-0.1	-0.9
Illnesses of siblings: Diabetes	0.2	0.2	0.4	0.6	-0.2
Ever had stillbirth, spontaneous miscarriage or termination	0.2	0.3	0.4	-0.4	-0.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.2	0.3	0.5	-0.7	0.1
Mineral and other dietary supplements	0.2	0.3	0.6	0.2	-0.8
Alcohol drinker status: Never	0.2	0.3	0.5	0.1	-0.7
Diastolic blood pressure, automated reading	0.2	0.6	1.1	1.1	-0.0
Myopia	0.2	0.3	0.4	0.6	0.5
Vascular/heart problems diagnosed by doctor	0.2	0.5	1.0	0.2	1.0
Leg fat mass (left)	0.2	0.7	1.1	-0.6	1.0
Depressed Affect (Nagel 2018)	0.1	0.2	0.5	0.7	0.1
Neuroticism (Nagel 2018)	0.1	0.3	0.4	0.7	0.3
Schizophrenia (2018)	0.1	0.3	0.6	-0.8	-0.1
Crohns Disease (2017)	0.1	0.2	0.5	-0.7	-0.0
Irritable Bowel Disease (IBD)	0.1	0.2	0.2	-0.5	0.4
Ulcerative Colitis (UC)	0.1	0.2	0.2	-0.4	0.4
Body Mass Index (BMI) (2010)	0.1	0.2	0.4	-0.1	-0.6
Rheumatoid Arthritis	0.1	0.2	0.4	0.2	0.6
Neuroticism	0.1	0.2	0.3	0.4	-0.5
Hand grip strength (left)	0.1	0.3	0.4	0.6	0.5
Relative age of first facial hair	0.1	0.2	0.3	0.6	-0.3
Maternal smoking around birth	0.1	0.1	0.2	0.1	0.4
Medication: Levothyroxine sodium	0.1	0.2	0.3	-0.6	-0.2
Chronic bronchitis/emphysema (father)	0.1	0.1	0.2	-0.2	0.4
Waist circumference	0.1	0.5	0.9	-1.0	0.2
Nervous feelings	0.1	0.2	0.5	-0.7	0.1
Hearing difficulty/problems with background noise	0.1	0.2	0.2	-0.5	-0.3
Fluid intelligence score	0.1	0.3	0.6	0.0	0.8
Frequency of tiredness / lethargy in last 2 weeks	0.1	0.1	0.2	0.1	-0.5
Noisy workplace	0.1	0.2	0.3	0.5	-0.2
Blood clot in the leg (DVT)	0.1	0.1	0.2	-0.5	0.2
Medication: Amlodipine	0.1	0.1	0.1	0.3	-0.3
Leg fat percentage (right)	0.1	0.3	0.3	-0.6	-0.5
Age at first live birth	0.1	0.2	0.4	-0.7	-0.0
Qualifications: College or University degree	0.1	0.2	0.3	0.1	0.6
Medication: Ibuprofen	0.1	0.1	0.1	-0.2	0.4
Mood swings	0.1	0.2	0.2	-0.5	-0.3
Mouth/teeth dental problems: Mouth ulcers	0.1	0.2	0.3	-0.3	0.5
Smoking status: Current	0.1	0.1	0.2	0.2	-0.4
Average weekly champagne plus white wine intake	0.1	0.1	0.2	-0.5	0.0
Financial situation satisfaction	0.1	0.1	0.2	-0.2	0.4
Pain type(s) experienced in last month: Hip pain	0.1	0.1	0.1	0.2	0.3
Medication: Atorvastatin	0.1	0.1	0.1	0.3	0.2
Illnesses of father: High blood pressure	0.1	0.2	0.3	0.5	-0.1
Leg fat percentage (left)	0.1	0.2	0.2	-0.5	-0.4
Number of operations (self-reported)	0.1	0.1	0.2	-0.4	-0.2
Fractured/broken bones in last 5 years	0.1	0.1	0.2	0.1	-0.4
Cholesterol lowering medication	0.1	0.2	0.4	-0.2	0.6
Depression (Nagel 2018)	0.0	0.1	0.1	-0.3	-0.1
Worry (Nagel 2018)	0.0	0.0	0.0	-0.1	-0.2
Age at First Birth	0.0	0.0	0.1	-0.0	-0.3
Primary Biliary Cirrhosis	0.0	0.0	0.0	0.2	-0.2
Ulcerative Colitis	0.0	0.0	0.1	0.0	0.3
Blood Eosinophil Count	0.0	0.1	0.1	0.3	-0.3
Blood Platelet Count	0.0	0.0	0.0	0.1	-0.2
Allergy or Eczema	0.0	0.1	0.1	0.4	-0.2
Cardiovascular Disease	0.0	0.1	0.1	0.2	-0.3
Hair Pigment	0.0	1.4	2.5	1.6	-0.5
Hearing difficulty/problems: Yes	0.0	0.0	0.0	0.1	0.1
Ever had hysterectomy (womb removed)	0.0	0.0	0.0	-0.1	0.0
Medication: Co-codamol	0.0	0.0	0.0	-0.2	0.2
Hand grip strength (right)	0.0	0.1	0.1	0.4	0.3
Hayfever, allergic rhinitis or eczema	0.0	0.1	0.1	-0.2	0.3
Stomach or abdominal pain in last month	0.0	0.0	0.0	0.0	-0.1
Time employed in main current job	0.0	0.0	0.1	0.0	-0.2
Emphysema/chronic bronchitis	0.0	0.0	0.0	0.1	0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.0	0.0	0.0	-0.1	0.2
Suffer from ‘nerves’	0.0	0.1	0.1	-0.2	0.3
Overall health rating	0.0	0.1	0.1	-0.3	-0.1
Age at last live birth	0.0	0.0	0.0	-0.2	-0.1
Handedness (chirality/laterality): Left-handed	0.0	0.0	0.1	-0.0	0.3
Deep venous thrombosis (DVT) (self-reported)	0.0	0.0	0.0	-0.1	-0.1

Hub : Genes

ADAMTS6

Models

Trait associations