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chr5:100,875,868-103,244,640

Best TWAS P=1.64e-16 · Best GWAS P=1.41e-16 conditioned to 0.0696

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	SLCO4C1	0.25	0.28	enet	41	0.30	1.8e-37	5.1	-5.2	1.7e-07	0.05	1.00	0.00	TRUE
2	GTEx	Adipose Subcutaneous	PPIP5K2	0.07	0.10	lasso	3	0.12	1.2e-09	-7.7	7.6	2.3e-14	-0.85	0.22	0.78	FALSE
3	GTEx	Adrenal Gland	PPIP5K2	0.16	0.17	lasso	5	0.18	5.9e-07	-7.8	8.0	1.8e-15	-0.89	0.18	0.82	FALSE
4	GTEx	Artery Aorta	PPIP5K2	0.08	0.07	lasso	3	0.07	1.2e-04	-7.7	7.8	8.6e-15	-0.85	0.22	0.76	FALSE
5	GTEx	Artery Aorta	PAM	0.06	0.03	lasso	6	0.02	2.5e-02	-4.3	-5.4	6.6e-08	0.36	0.21	0.11	FALSE
6	GTEx	Brain Cerebellar Hemisphere	PAM	0.27	0.10	lasso	4	0.13	2.7e-04	-4.5	-5.5	3.1e-08	0.60	0.18	0.74	FALSE
7	GTEx	Brain Nucleus accumbens basal ganglia	PPIP5K2	0.19	0.06	enet	22	0.05	1.7e-02	-7.2	7.0	3.5e-12	-0.85	0.11	0.61	FALSE
8	GTEx	Breast Mammary Tissue	PPIP5K2	0.11	0.10	lasso	5	0.04	2.7e-03	-8.0	7.8	8.1e-15	-0.88	0.09	0.87	FALSE
9	GTEx	Breast Mammary Tissue (Female)	PPIP5K2	0.09	0.01	lasso	7	0.00	2.9e-01	-7.4	7.5	7.8e-14	-0.90	0.08	0.65	FALSE
10	GTEx	Cells EBV-transformed lymphocytes	PPIP5K2	0.37	0.32	enet	22	0.37	6.6e-13	-7.6	-7.3	3.7e-13	0.83	0.38	0.62	FALSE
11	GTEx	Colon Sigmoid	PPIP5K2	0.14	0.00	enet	17	0.04	1.9e-02	-7.9	6.8	1.2e-11	-0.82	0.11	0.80	FALSE
12	GTEx	Esophagus Gastroesophageal Junction	PPIP5K2	0.14	0.09	lasso	2	0.03	3.0e-02	-8.0	7.5	6.3e-14	-0.80	0.09	0.70	FALSE
13	GTEx	Esophagus Muscularis	PPIP5K2	0.05	0.02	enet	14	0.03	9.8e-03	-7.8	7.7	1.1e-14	-0.91	0.12	0.84	FALSE
14	GTEx	Muscle Skeletal	GIN1	0.04	0.01	lasso	3	0.00	1.5e-01	-5.5	-7.3	2.1e-13	0.81	0.12	0.56	FALSE
15	GTEx	Nerve Tibial	PPIP5K2	0.11	0.13	lasso	12	0.11	6.5e-08	-7.6	7.7	1.9e-14	-0.84	0.23	0.77	FALSE
16	GTEx	Pituitary	PPIP5K2	0.15	0.10	enet	13	0.11	1.2e-03	-7.6	7.8	4.4e-15	-0.81	0.13	0.54	FALSE
17	GTEx	Skin Sun Exposed Lower leg	PAM	0.04	0.00	lasso	4	0.04	2.3e-04	-5.6	-6.8	1.4e-11	0.82	0.09	0.53	FALSE
18	GTEx	Spleen	PPIP5K2	0.18	0.19	enet	15	0.19	1.1e-05	-7.4	-7.4	1.4e-13	0.84	0.20	0.77	FALSE
19	GTEx	Stomach	PPIP5K2	0.05	0.04	lasso	2	0.03	8.7e-03	-7.6	7.6	2.1e-14	-0.83	0.11	0.64	FALSE
20	GTEx	Whole Blood	PPIP5K2	0.14	0.06	lasso	6	0.08	1.6e-07	-7.6	6.8	9.6e-12	-0.77	0.27	0.73	FALSE
21	GTEx	Whole Blood	PAM	0.20	0.28	lasso	9	0.27	1.0e-24	-5.3	-5.2	2.4e-07	0.74	1.00	0.00	FALSE
22	METSIM	Adipose	PAM	0.04	0.02	lasso	2	0.02	2.9e-04	-5.4	-5.3	1.3e-07	0.73	0.58	0.13	FALSE
23	METSIM	Adipose	PPIP5K2	0.05	0.07	blup	347	0.07	6.3e-11	-7.7	6.9	3.9e-12	-0.83	0.14	0.86	FALSE
24	NTR	Blood	PAM	0.26	0.29	lasso	1	0.29	2.6e-95	-5.3	-5.3	1.3e-07	0.73	1.00	0.00	FALSE
25	NTR	Blood	PPIP5K2	0.03	0.04	enet	10	0.04	5.3e-14	-7.2	6.8	9.3e-12	-0.76	0.53	0.47	FALSE
26	ROSMAP	Brain Pre-frontal Cortex	GIN1	0.02	0.01	blup	253	0.01	2.3e-02	-7.5	-6.9	5.5e-12	0.85	0.07	0.52	FALSE
27	YFS	Blood	GIN1	0.02	0.04	lasso	7	0.05	5.1e-17	-7.3	-6.7	1.7e-11	0.91	0.08	0.92	FALSE
28	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	PPIP5K2	0.03	0.03	lasso	3	0.03	1.4e-03	-7.5	-7.7	9.5e-15	0.89	0.01	0.88	FALSE
29	The Cancer Genome Atlas	Breast Invasive Carcinoma	GIN1	0.01	0.01	blup	21	0.01	1.7e-03	-7.5	-7.6	2.1e-14	0.87	0.02	0.83	FALSE
30	The Cancer Genome Atlas	Breast Invasive Carcinoma	PPIP5K2	0.01	0.01	blup	17	0.01	9.3e-04	-7.6	-7.7	1.5e-14	0.87	0.02	0.84	FALSE
31	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	GIN1	0.11	0.03	blup	21	0.05	1.7e-03	-7.7	-7.4	9.5e-14	0.82	0.01	0.80	FALSE
32	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	PPIP5K2	0.16	0.03	lasso	3	0.05	2.6e-03	-7.9	-7.4	1.9e-13	0.85	0.00	0.86	FALSE
33	The Cancer Genome Atlas	Colon Adenocarcinoma	PPIP5K2	0.05	0.03	blup	17	0.03	7.1e-03	-7.5	-6.8	7.6e-12	0.78	0.02	0.69	FALSE
34	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	PPIP5K2	0.04	0.04	blup	16	0.05	4.1e-06	-7.6	-7.2	8.3e-13	0.82	0.02	0.98	FALSE
35	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	GIN1	0.13	0.01	enet	6	0.02	7.0e-03	-7.5	-7.4	1.0e-13	0.78	0.01	0.32	FALSE
36	The Cancer Genome Atlas	Brain Lower Grade Glioma	GIN1	0.08	0.08	lasso	5	0.09	3.1e-10	-7.6	-7.0	1.8e-12	0.83	0.02	0.98	FALSE
37	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	PPIP5K2	0.04	0.03	blup	17	0.03	1.1e-02	-7.5	-7.2	5.4e-13	0.83	0.01	0.74	FALSE
38	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	PAM	0.09	0.03	lasso	2	0.03	3.2e-02	-8.0	-8.2	1.6e-16	0.86	0.02	0.38	TRUE
39	The Cancer Genome Atlas	Prostate Adenocarcinoma	GIN1	0.03	0.03	blup	22	0.03	5.5e-04	-7.2	-7.4	1.8e-13	0.87	0.02	0.95	FALSE
40	The Cancer Genome Atlas	Soft Tissue Sarcoma	GIN1	0.03	0.02	blup	21	0.03	7.9e-03	-7.6	-7.7	1.5e-14	0.88	0.01	0.64	FALSE
41	The Cancer Genome Atlas	Testicular Germ Cell Tumors	PPIP5K2	0.26	0.21	lasso	7	0.23	1.2e-08	-7.5	-7.1	9.7e-13	0.82	0.02	0.98	FALSE
42	The Cancer Genome Atlas	Thyroid Carcinoma	GIN1	0.06	0.07	lasso	3	0.06	1.6e-06	-7.6	-7.7	1.3e-14	0.86	0.01	0.99	FALSE