Best TWAS P=3.51e-40 · Best GWAS P=5.71e-48 conditioned to 3.34e-11
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Adipose Subcutaneous | CEP120 | 0.12 | 0.08 | lasso | 3 | 0.05 | 5.5e-05 | 5.4 | 5.9 | 3.2e-09 | -0.29 | 0.87 | 0.01 | FALSE |
2 | GTEx | Artery Aorta | CSNK1G3 | 0.11 | 0.07 | lasso | 2 | 0.01 | 6.5e-02 | -9.0 | -9.0 | 2.0e-19 | 0.52 | 0.15 | 0.09 | FALSE |
3 | GTEx | Artery Aorta | KRT8P33 | 0.10 | 0.04 | lasso | 6 | 0.05 | 9.1e-04 | -7.9 | 10.9 | 8.2e-28 | -0.62 | 0.03 | 0.87 | FALSE |
4 | GTEx | Esophagus Mucosa | CSNK1G3 | 0.14 | 0.05 | lasso | 3 | 0.07 | 2.0e-05 | 9.3 | 9.5 | 2.2e-21 | -0.44 | 0.78 | 0.11 | FALSE |
5 | METSIM | Adipose | LOX | 0.11 | 0.06 | enet | 15 | 0.07 | 2.7e-10 | 6.1 | -6.3 | 3.1e-10 | 0.03 | 0.88 | 0.12 | FALSE |
6 | The Cancer Genome Atlas | Breast Invasive Carcinoma | CSNK1G3 | 0.04 | 0.02 | enet | 8 | 0.02 | 1.2e-04 | 9.4 | 11.0 | 3.1e-28 | -0.56 | 0.00 | 0.88 | TRUE |
7 | The Cancer Genome Atlas | Colon Adenocarcinoma | CEP120 | 0.06 | 0.02 | blup | 70 | 0.04 | 3.6e-03 | 7.7 | 10.7 | 7.2e-27 | -0.64 | 0.08 | 0.44 | FALSE |
8 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | CEP120 | 0.03 | 0.02 | enet | 5 | 0.04 | 7.3e-05 | -7.9 | 10.7 | 9.3e-27 | -0.66 | 0.04 | 0.81 | FALSE |
9 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | LOX | 0.17 | 0.15 | blup | 35 | 0.17 | 6.8e-19 | 6.1 | 7.2 | 7.4e-13 | 0.08 | 0.02 | 0.98 | TRUE |
10 | The Cancer Genome Atlas | Lung Adenocarcinoma | CSNK1G3 | 0.06 | 0.05 | lasso | 2 | 0.04 | 2.0e-05 | 9.3 | 9.3 | 2.2e-20 | -0.44 | 0.00 | 1.00 | FALSE |
11 | The Cancer Genome Atlas | Prostate Adenocarcinoma | CEP120 | 0.10 | 0.14 | blup | 70 | 0.14 | 2.6e-14 | -14.3 | 13.3 | 3.5e-40 | -0.83 | 0.04 | 0.96 | TRUE |
12 | The Cancer Genome Atlas | Prostate Adenocarcinoma | CSNK1G3 | 0.06 | 0.04 | enet | 10 | 0.05 | 2.3e-06 | 8.0 | 10.1 | 3.8e-24 | -0.57 | 0.13 | 0.84 | FALSE |