Best TWAS P=3.62e-49 · Best GWAS P=1.29e-46 conditioned to NaN
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | CCDC112 | 0.04 | 0.00 | blup | 433 | 0.01 | 3.5e-02 | 2.05 | 6.0 | 2.6e-09 | 0.36 | 0.15 | 0.20 | TRUE |
| 2 | GTEx | Adipose Subcutaneous | CDO1 | 0.12 | 0.04 | lasso | 6 | 0.05 | 7.0e-05 | 14.23 | -13.7 | 8.5e-43 | -0.87 | 0.01 | 0.99 | FALSE |
| 3 | GTEx | Adrenal Gland | PGGT1B | 0.25 | -0.01 | enet | 37 | 0.01 | 1.1e-01 | -0.69 | -5.1 | 2.7e-07 | -0.25 | 0.05 | 0.12 | TRUE |
| 4 | GTEx | Artery Aorta | CDO1 | 0.27 | 0.15 | enet | 16 | 0.15 | 1.7e-08 | 14.23 | -13.9 | 5.8e-44 | -0.92 | 0.01 | 0.99 | FALSE |
| 5 | GTEx | Artery Tibial | CDO1 | 0.24 | 0.15 | lasso | 6 | 0.12 | 5.3e-10 | 14.23 | -14.7 | 3.6e-49 | -0.94 | 0.00 | 1.00 | TRUE |
| 6 | GTEx | Breast Mammary Tissue (Female) | PGGT1B | 0.15 | -0.01 | enet | 29 | 0.00 | 2.7e-01 | 8.24 | -5.4 | 7.5e-08 | -0.38 | 0.05 | 0.06 | FALSE |
| 7 | GTEx | Esophagus Muscularis | AP3S1 | 0.19 | 0.00 | enet | 44 | 0.01 | 4.4e-02 | -3.53 | -5.5 | 4.6e-08 | -0.29 | 0.21 | 0.09 | TRUE |
| 8 | GTEx | Pituitary | AC010226.4 | 0.50 | 0.04 | enet | 23 | 0.21 | 5.1e-06 | 6.96 | -5.8 | 8.7e-09 | -0.27 | 0.12 | 0.14 | TRUE |
| 9 | GTEx | Thyroid | CDO1 | 0.19 | 0.14 | enet | 16 | 0.16 | 1.6e-12 | -2.94 | -6.2 | 5.4e-10 | -0.07 | 1.00 | 0.00 | TRUE |
| 10 | METSIM | Adipose | CDO1 | 0.07 | 0.01 | bslmm | 537 | 0.02 | 7.9e-04 | 14.23 | -13.0 | 1.5e-38 | -0.69 | 0.00 | 0.99 | TRUE |
| 11 | METSIM | Adipose | PGGT1B | 0.05 | 0.02 | bslmm | 424 | 0.02 | 2.1e-03 | 1.20 | -5.5 | 4.7e-08 | -0.32 | 0.22 | 0.11 | TRUE |
| 12 | METSIM | Adipose | TRIM36 | 0.04 | 0.00 | blup | 432 | 0.01 | 1.3e-02 | -2.46 | -5.6 | 2.6e-08 | -0.31 | 0.09 | 0.48 | TRUE |
| 13 | NTR | Blood | TMED7 | 0.02 | 0.02 | enet | 9 | 0.02 | 3.3e-06 | -7.52 | -7.7 | 1.6e-14 | -0.54 | 1.00 | 0.00 | TRUE |
| 14 | ROSMAP | Brain Pre-frontal Cortex | CDO1 | 0.13 | 0.01 | blup | 523 | 0.06 | 9.0e-08 | -3.82 | -7.3 | 2.2e-13 | -0.15 | 0.21 | 0.25 | TRUE |
| 15 | YFS | Blood | CCDC112 | 0.02 | 0.00 | bslmm | 419 | 0.00 | 2.9e-02 | 7.63 | 7.8 | 4.5e-15 | 0.48 | 0.05 | 0.31 | FALSE |
| 16 | The Cancer Genome Atlas | Breast Invasive Carcinoma | TICAM2 | 0.02 | 0.01 | blup | 40 | 0.01 | 2.8e-03 | 7.52 | 7.3 | 3.4e-13 | 0.30 | 0.12 | 0.14 | TRUE |
| 17 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | TICAM2 | 0.04 | 0.00 | blup | 40 | 0.01 | 1.4e-02 | 5.40 | 8.6 | 1.1e-17 | 0.46 | 0.05 | 0.37 | FALSE |
| 18 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | TMED7-TICAM2 | 0.04 | 0.02 | lasso | 4 | 0.02 | 4.8e-03 | -7.32 | 8.7 | 3.0e-18 | 0.50 | 0.04 | 0.40 | TRUE |