Best TWAS P=2.35e-28 · Best GWAS P=1.23e-40 conditioned to 5.78e-16
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | GLCCI1 | 0.20 | 0.10 | enet | 44 | 0.15 | 9.5e-18 | -8.0 | -9.7 | 2.9e-22 | 0.76 | 0.01 | 0.99 | FALSE |
| 2 | GTEx | Colon Transverse | RP5-1159O4.1 | 0.21 | 0.03 | enet | 22 | 0.04 | 6.6e-03 | -12.8 | -8.0 | 1.6e-15 | 0.71 | 0.06 | 0.72 | FALSE |
| 3 | GTEx | Testis | KDELR2 | 0.36 | 0.33 | lasso | 4 | 0.31 | 1.7e-14 | 5.6 | -6.0 | 2.1e-09 | -0.01 | 0.00 | 1.00 | TRUE |
| 4 | METSIM | Adipose | KDELR2 | 0.03 | 0.04 | lasso | 7 | 0.02 | 3.7e-04 | 5.6 | 5.1 | 2.7e-07 | -0.01 | 0.00 | 1.00 | FALSE |
| 5 | ROSMAP | Brain Pre-frontal Cortex | GLCCI1 | 0.19 | 0.15 | enet | 19 | 0.20 | 1.8e-25 | -8.5 | -11.0 | 2.3e-28 | 0.68 | 0.88 | 0.12 | TRUE |
| 6 | ROSMAP | Brain Pre-frontal Cortex | AC006042.8 | 0.24 | 0.07 | lasso | 4 | 0.17 | 3.1e-21 | -12.8 | 8.7 | 3.9e-18 | -0.79 | 0.04 | 0.96 | FALSE |