Hub : Genes

GLCCI1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.198	0.0340	1.5e-14	0.097	0.125	0.149	0.136	0.142	7.1e-12	5.5e-15	9.5e-18	3.3e-16	5.8e-17
2	ROSMAP	Brain Pre-frontal Cortex	0.190	0.0326	3.7e-15	0.150	0.152	0.202	0.188	0.196	8.8e-19	5.0e-19	1.8e-25	1.5e-23	1.2e-24
3	TCGA	Thyroid Carcinoma	0.187	0.0480	9.1e-08	0.092	0.085	0.072	NA	0.081	3.0e-09	1.1e-08	1.4e-07	NA	2.6e-08

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bipolar Disorder (2018)	0.3	0.5	0.9	-0.9	-0.3	-0.6
Bipolar Disorder or Schizophrenia	0.5	1.2	1.9	-1.4	-1.1	-0.6
Depressed Affect (Nagel 2018)	0.2	0.3	0.8	0.4	-0.9	0.2
Depression (Nagel 2018)	0.4	0.6	1.5	1.2	-0.2	0.4
Intelligence (Savage-Jansen 2018)	3.8	11.8	23.6	-3.2	-4.9	-1.0
Neuroticism (Nagel 2018)	0.3	0.7	2.1	1.5	-0.0	-0.1
Schizophrenia (2018)	0.4	0.9	1.7	-1.0	-1.3	-0.1
Schizophrenia vs Biploar Disorder	0.3	0.4	0.8	-0.1	-0.9	0.7
Worry (Nagel 2018)	1.7	3.5	8.9	3.0	1.3	-0.1
Alzheimer’s Disease (in mother)	2.6	3.0	4.6	1.8	1.0	-2.2
Alzheimer’s Disease (in father)	3.4	3.6	5.2	2.0	2.3	-1.3
Alzheimer’s Disease (including proxy)	4.6	6.7	7.6	2.7	2.6	-2.5
Crohns Disease (2017)	1.5	3.3	9.5	0.0	-0.6	3.1
Irritable Bowel Disease (IBD)	1.6	3.9	4.4	2.1	1.8	2.0
Ulcerative Colitis (UC)	3.8	7.1	11.9	3.0	3.5	0.6
Major Depression (MDD)	0.1	0.1	0.2	-0.0	0.3	-0.4
Reaction Time	0.0	0.1	0.2	-0.1	0.1	-0.4
Verbal and Numeric Reasoning (VNR)	2.2	5.2	10.2	-2.2	-3.2	-0.8
Breast Cancer	1.1	2.7	6.4	1.0	0.9	2.5
Ovarian Cancer	0.2	0.2	0.4	-0.5	-0.6	0.3
Prostate Cancer	1.9	2.7	5.3	2.3	1.2	-1.2
Age at First Birth	1.3	1.8	4.2	-1.1	-2.1	0.1
Bipolar Disorder (2011)	1.2	1.2	3.0	-1.7	-0.7	-0.1
Body Mass Index (BMI) (2010)	0.0	0.0	0.1	-0.2	0.1	-0.3
Coronary Artery Disease (CAD)	0.4	0.4	1.2	-0.0	-1.1	0.3
Crohns Disease (2012)	0.3	0.5	1.4	0.2	0.4	1.2
Mean Putamen Volume	1.8	2.0	3.6	1.1	1.1	-1.9
Fasting Glucose	2.0	2.3	5.5	0.1	-1.2	-2.3
HbA1C	0.8	0.9	1.7	-1.3	-0.6	0.7
HDL Cholesterol	0.5	0.8	1.6	0.7	1.3	-0.5
LDL Cholesterol	0.4	0.6	1.4	-0.7	0.2	1.2
Lupus	0.3	0.4	0.8	0.3	-0.9	-0.5
Neuroticism (2016)	0.5	0.7	1.8	-0.3	-1.3	0.6
Primary Biliary Cirrhosis	1.3	1.8	5.4	-0.0	-0.1	-2.3
Rheumatoid Arthritis	0.7	1.0	1.6	-0.9	-1.3	0.7
Schizophrenia (2014)	0.3	0.6	1.2	-0.6	-1.1	-0.5
Triglycerides	0.1	0.2	0.5	-0.2	0.7	-0.4
Type 2 Diabetes (T2D) (2012)	0.8	0.9	2.3	0.5	-0.3	1.5
Ulcerative Colitis	5.3	7.7	12.9	3.1	3.6	0.4
Blood Eosinophil Count	0.4	3.1	5.8	-0.7	-2.4	-1.8
Blood Platelet Count	0.1	1.3	2.1	-1.4	-1.3	-0.4
Blood Red Count	0.1	0.8	2.0	-0.5	-0.3	-1.4
Blood White Count	0.6	4.4	12.6	0.7	-3.5	0.5
Heel T-Score	0.2	1.8	3.5	1.3	0.5	-1.9
BMI	0.3	1.5	4.2	2.0	0.3	-0.5
Height	3.8	73.0	121.0	-9.7	-11.0	2.0
Waist Hip Ratio (WHR)	0.1	0.6	0.9	0.6	0.9	0.7
Systolic Blood Pressure	0.2	0.8	1.4	1.2	-0.1	-1.0
Smoking Status	0.1	0.1	0.3	0.4	0.0	-0.5
Allergy or Eczema	0.0	0.1	0.1	0.1	-0.2	0.4
Cardiovascular Disease	0.1	0.3	0.4	-0.4	-0.5	-0.7
Hypothyroidism (self reported)	0.3	0.7	1.7	0.4	1.3	-0.5
Respiratory disease	0.1	0.3	0.6	0.2	-0.4	-0.8
Type 2 Diabetes (T2D) (2018)	1.8	3.3	4.3	2.1	1.5	-1.9
Lung FEV1/FVC ratio	0.3	1.3	2.1	0.7	-1.2	1.5
Lung FVC	1.7	8.8	13.5	3.6	3.7	-0.3
Neuroticism	0.1	0.3	0.5	0.7	-0.6	0.4
Chronotype (morning person)	0.4	0.9	2.4	-0.6	-1.5	0.2
Hair Pigment	0.2	5.8	10.8	-2.4	-3.3	-0.8
Tanning	0.2	2.8	3.5	1.3	1.9	1.9
Hand grip strength (left)	1.8	4.8	10.3	-1.9	-3.2	-0.8
Number of treatments/medications taken	0.7	1.2	2.4	1.5	0.4	-1.1
Average weekly spirits intake	1.3	1.6	3.6	1.0	-0.4	-1.9
Sensitivity / hurt feelings	0.2	0.3	0.9	0.9	-0.4	0.1
Frequency of depressed mood in last 2 weeks	0.4	0.6	1.6	-0.1	-0.5	1.2
Hearing difficulty/problems: Yes	0.5	0.8	2.2	0.0	0.5	1.5
Relative age of first facial hair	0.3	0.7	1.1	0.9	0.4	-1.0
Other serious medical condition/disability diagnosed by doctor	0.3	0.4	0.9	-1.0	-0.5	0.2
Ever used hormone-replacement therapy (HRT)	0.8	1.0	2.2	-0.6	-0.6	1.5
Ever had hysterectomy (womb removed)	1.7	1.9	3.6	-1.9	-0.6	1.3
Systolic blood pressure, automated reading	0.6	1.8	4.3	2.1	0.9	-0.5
Eye problems/disorders: Diabetes related eye disease	3.2	3.5	5.1	2.1	2.3	-1.1
Angina	0.1	0.1	0.2	0.4	0.0	0.4
Medication for hormone replacement therapy	2.4	2.7	7.7	-0.4	-2.8	-0.3
Vitamin and mineral supplements	0.2	0.3	0.9	-0.2	-0.2	-0.9
Supplements: Zinc	0.2	0.2	0.5	0.0	0.2	0.7
Medication: Co-codamol	1.8	2.0	3.6	1.9	1.6	0.2
Medication: Metformin	2.0	2.8	5.7	2.4	1.6	-0.4
Diabetes (father)	0.3	0.3	0.7	0.8	0.1	-0.6
Diabetes (mother)	0.6	0.7	1.8	-0.5	-1.3	-0.4
Severe depression (siblings)	3.1	3.5	6.2	-2.0	-2.5	-0.5
Pack years adult smoking proportion	0.0	0.0	0.1	-0.2	-0.2	0.1
Impedance of leg (right)	0.3	1.6	1.8	-1.2	1.3	-1.3
Leg fat-free mass (left)	1.1	6.0	13.6	-2.1	-3.7	0.3
Trunk fat percentage	0.4	1.5	3.5	0.8	0.6	-1.9
Hand grip strength (right)	1.9	5.2	11.0	-2.1	-3.3	0.4
Townsend deprivation index at recruitment	0.9	1.3	2.0	1.4	1.4	0.1
Current tobacco smoking	0.6	0.9	1.7	-0.6	-0.8	-1.3
Average weekly fortified wine intake	0.7	0.8	1.3	1.1	1.1	0.1
Maternal smoking around birth	0.2	0.3	0.6	0.8	-0.3	-0.4
Fed-up feelings	0.2	0.3	0.9	0.9	0.3	-0.0
Frequency of unenthusiasm / disinterest in last 2 weeks	0.1	0.2	0.2	0.3	-0.4	0.5
Relative age voice broke	0.6	0.9	1.4	1.2	0.1	-1.1
Taking other prescription medications	1.5	2.3	3.8	2.0	1.0	-1.4
Age when periods started (menarche)	0.7	1.7	2.7	1.6	1.5	-0.5
Bilateral oophorectomy (both ovaries removed)	0.1	0.1	0.3	-0.2	0.0	-0.5
Heel bone mineral density (BMD) T-score, automated (left)	0.9	2.0	3.6	1.9	1.1	-1.1
Tinnitus: Yes, but not now, but have in the past	0.5	0.6	1.0	-1.0	-0.6	0.6
Qualifications: CSEs or equivalent	1.4	1.9	3.8	1.1	0.7	2.0
Serious illness, injury or assault to yourself	0.2	0.2	0.3	0.6	-0.1	0.5
High blood pressure	0.0	0.1	0.1	0.3	0.2	-0.2
Hayfever, allergic rhinitis or eczema	0.3	0.6	0.8	-0.4	-0.9	0.9
Multivitamins +/- minerals	0.2	0.2	0.4	-0.5	0.1	0.6
Stomach or abdominal pain in last month	0.7	0.9	1.6	1.3	0.5	-0.9
Supplements: Glucosamine	0.8	1.1	2.3	-0.6	-1.5	0.7
Diverticular disease/diverticulitis (self-reported)	1.6	2.0	4.7	-0.5	-2.2	-0.9
Medication: Atenolol	0.7	0.8	1.4	1.0	1.2	-0.4
Medication: Levothyroxine sodium	0.1	0.1	0.3	0.2	0.5	-0.1
Sitting height	1.5	10.7	18.7	-3.7	-4.3	-0.0
Chronic bronchitis/emphysema (father)	0.6	0.8	1.1	-0.8	-1.1	-0.7
High blood pressure (mother)	0.4	0.5	1.3	-1.1	0.2	-0.6
Body mass index (BMI)	0.6	2.5	5.2	2.3	1.4	-0.7
Impedance of leg (left)	0.4	1.7	3.5	-0.6	1.2	-1.9
Leg predicted mass (left)	1.2	6.3	14.1	-2.2	-3.8	0.3
Trunk fat mass	0.3	1.1	2.2	-0.2	-1.1	-1.5
Waist circumference	0.1	0.5	1.4	1.2	0.1	0.1
Number of incorrect matches in round	0.7	1.1	3.2	-1.8	-0.0	-0.3
Past tobacco smoking	0.0	0.1	0.1	0.1	0.3	0.3
Alcohol usually taken with meals	0.6	0.9	1.4	-0.4	-1.1	-1.2
Nervous feelings	1.1	2.1	5.5	2.4	0.9	0.0
Frequency of tenseness / restlessness in last 2 weeks	1.0	1.5	3.0	1.2	-0.3	1.7
Hearing difficulty/problems with background noise	0.9	1.5	3.5	0.6	0.8	1.9
Hair/balding pattern: Pattern 2	1.2	1.6	3.7	0.9	0.5	1.9
Had menopause	0.2	0.3	0.4	0.6	0.5	0.5
Had other major operations	0.5	0.6	1.5	0.6	1.2	0.2
Forced vital capacity (FVC)	0.5	1.8	3.9	-1.0	-2.0	-0.7
Heel bone mineral density (BMD) T-score, automated (right)	1.2	2.7	4.0	2.0	1.0	-1.8
Ever unenthusiastic/disinterested for a whole week	0.6	0.7	1.1	1.1	0.4	1.0
Qualifications: None of the above	3.0	6.4	9.0	3.0	3.0	1.2
Financial difficulties in last 2 years	1.0	1.3	2.6	1.1	0.4	1.6
Mouth/teeth dental problems	1.6	2.4	3.5	-1.8	-1.9	-0.7
Heart attack	0.7	0.9	1.3	1.1	1.0	0.6
Allergy	0.1	0.3	0.5	-0.1	0.6	-0.7
Pain all over the body in last month	1.1	1.1	2.5	1.6	0.7	-0.6
Diabetes (self-reported)	1.7	2.6	4.2	2.0	1.6	-1.1
Hayfever/allergic rhinitis (self-reported)	0.6	0.8	2.1	0.3	-0.2	-1.5
Medication: Ramipril	0.6	0.8	2.0	-0.0	-0.7	-1.4
Medication: Simvastatin	0.7	1.0	1.8	0.8	1.3	0.8
Fluid intelligence score	0.7	1.5	2.8	-1.2	-1.7	0.4
Illnesses of siblings	0.4	0.6	1.4	0.5	-0.3	-1.2
Neuroticism score	0.4	0.8	1.3	1.1	-0.3	1.1
Weight	0.5	2.4	5.7	-1.1	-2.4	-0.5
Impedance of arm (right)	0.1	0.5	0.8	-0.9	0.5	-0.7
Arm fat percentage (right)	0.6	2.5	4.3	2.1	1.6	-0.8
Trunk fat-free mass	2.2	12.4	25.9	-3.2	-5.1	1.1
Hip circumference	0.2	1.1	2.7	-0.7	-1.6	-0.2
Time employed in main current job	0.2	0.3	0.6	0.4	0.8	-0.3
Alcohol intake versus 10 years previously	0.0	0.1	0.2	0.1	0.4	-0.2
Father’s age at death	0.3	0.4	0.9	-0.3	-0.9	0.5
Worrier / anxious feelings	1.4	2.7	6.5	2.6	1.2	0.4
Frequency of tiredness / lethargy in last 2 weeks	0.4	0.6	1.6	1.2	0.5	0.3
Falls in the last year	1.6	2.2	5.6	-0.8	0.5	-2.4
Hair/balding pattern: Pattern 3	0.1	0.2	0.4	0.4	-0.6	0.2
Number of live births	1.7	2.5	6.0	-0.6	2.5	1.0
Forced expiratory volume in 1-second (FEV1)	0.4	1.2	3.3	-0.6	-1.8	-0.3
Pulse rate	0.2	0.4	0.6	0.7	-0.3	-0.7
Happiness	0.7	0.8	1.3	0.9	-1.1	0.5
Noisy workplace	3.6	4.4	5.3	2.3	1.8	2.1
Qualifications: A levels/AS levels or equivalent	0.6	1.4	2.2	-1.4	-1.5	-0.1
Serious illness, injury or assault of a close relative in last 2 years	2.2	2.6	5.6	-1.3	-2.4	-0.7
Mouth/teeth dental problems: Dentures	0.5	0.8	1.9	-0.0	1.4	0.6
Asthma	0.3	0.6	1.2	1.1	0.5	-0.5
Medication: Ibuprofen (e.g. Nurofen)	1.4	1.8	5.0	0.5	0.2	-2.2
Medication: Cholesterol lowering	0.1	0.1	0.2	-0.4	-0.4	0.3
Depression (self-reported)	1.0	1.2	2.2	1.5	-0.5	1.0
Medication: Lansoprazole	0.9	1.0	2.1	1.4	0.7	-0.7
Prospective memory result	0.6	0.7	1.6	-0.7	0.1	-1.3
Lung cancer (father)	1.2	1.4	1.8	1.3	0.9	-1.3
Illnesses of mother	0.1	0.1	0.2	-0.2	-0.4	0.3
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.8	1.3	0.3	-0.9	1.2
Pulse wave Arterial Stiffness index	0.1	0.2	0.4	-0.2	0.2	-0.6
Impedance of arm (left)	0.2	0.9	1.2	-1.1	0.7	-1.0
Arm fat mass (right)	0.1	0.4	0.9	1.0	0.0	-0.6
Trunk predicted mass	2.1	12.1	25.7	-3.1	-5.1	1.0
Standing height	4.3	42.4	71.7	-7.4	-8.5	0.1
Length of working week for main job	2.1	2.3	4.0	-1.7	-2.0	-0.3
Exposure to tobacco smoke at home	0.0	0.0	0.0	-0.2	-0.1	-0.2
Breastfed as a baby	0.7	0.8	2.4	0.3	0.1	-1.5
Tense / ‘highly strung’	0.2	0.3	0.6	0.7	-0.2	0.7
Seen doctor (GP) for nerves, anxiety, tension or depression	0.1	0.2	0.3	0.3	-0.2	0.6
Hair/balding pattern: Pattern 4	0.6	1.4	4.0	-0.3	-0.0	-2.0
Birth weight of first child	0.3	0.5	1.5	-0.3	0.1	1.2
Peak expiratory flow (PEF)	0.4	0.9	2.3	0.4	-1.5	-0.3
Pulse wave reflection index	0.1	0.2	0.4	0.4	0.6	0.2
Ever highly irritable/argumentative for 2 days	0.5	0.6	1.4	-0.3	-1.2	0.4
Loud music exposure frequency	2.1	2.2	3.8	1.9	1.7	-0.0
Qualifications: O levels/GCSEs or equivalent	0.1	0.1	0.1	-0.3	0.3	-0.4
Mouth/teeth dental problems: Bleeding gums	1.6	2.0	4.8	2.2	1.1	-0.0
Blood clot in the leg (DVT)	0.5	0.7	1.1	-0.8	-0.5	1.0
Medication: Paracetamol	0.0	0.1	0.1	-0.2	-0.3	0.1
Headache pain in last month	0.5	0.9	2.2	-0.3	-1.5	0.5
Medication for cholesterol, blood pressure or diabetes	0.1	0.1	0.2	-0.4	0.1	0.3
Glaucoma (self-reported)	0.7	0.8	1.6	-1.3	-0.9	-0.1
Gout (self-reported)	0.3	0.4	0.6	-0.5	-0.6	0.7
Hypothyroidism/myxoedema (self-reported)	0.6	1.1	1.5	0.7	1.2	-1.1
Medication: Amlodipine	0.4	0.5	1.3	-0.5	-0.2	1.2
Medication: Ventolin 100micrograms inhaler	0.7	0.9	2.4	0.2	0.7	-1.5
Birth weight	0.6	1.2	1.5	-1.0	-1.1	1.2
Chronic bronchitis/emphysema (mother)	0.5	0.5	0.8	0.2	0.9	-0.8
High blood pressure (siblings)	0.6	0.8	2.4	-0.1	-0.1	1.5
Forced vital capacity (FVC), Best measure	0.1	0.4	0.8	-0.1	-0.9	0.7
Body fat percentage	0.5	2.0	3.3	1.3	1.1	-1.8
Leg fat percentage (right)	0.7	2.5	3.3	1.5	1.8	-1.4
Arm fat-free mass (right)	1.7	8.5	18.7	-2.6	-4.3	0.1
Exposure to tobacco smoke outside home	0.6	0.8	2.0	-0.6	-1.4	0.3
Comparative body size at age 10	0.2	0.5	0.9	-0.5	-0.5	-0.9
Number of full brothers	0.2	0.2	0.4	0.3	0.3	-0.7
Worry too long after embarrassment	0.4	0.7	1.8	-0.1	-1.3	0.4
Seen a psychiatrist for nerves, anxiety, tension or depression	0.7	0.9	1.7	-1.3	-0.8	0.7
Wheeze or whistling in the chest in last year	0.5	1.0	1.3	0.9	1.1	0.9
Number of children fathered	2.6	2.9	6.2	-1.3	-2.5	0.9
Reason for reducing amount of alcohol drunk: Health precaution	0.1	0.1	0.2	-0.3	-0.2	0.4
Age at first live birth	1.0	1.8	2.9	-1.5	-1.7	0.5
Pulse wave peak to peak time	0.3	0.3	0.6	-0.4	-0.8	0.5
Health satisfaction	2.8	3.6	7.6	2.8	1.7	0.8
Shortness of breath walking on level ground	0.4	0.4	0.8	0.9	0.3	-0.7
Qualifications: College or University degree	2.9	9.3	15.1	-3.2	-3.9	-1.5
Eye problems/disorders: None of the above	0.7	0.8	2.4	1.5	-0.4	0.2
Mouth/teeth dental problems: Loose teeth	1.7	2.0	4.5	0.8	1.0	-2.1
Emphysema/chronic bronchitis	0.7	0.8	2.4	0.0	-0.4	-1.5
Medication for pain relief, constipation, heartburn	0.3	0.5	0.9	-0.7	-1.0	0.5
Neck or shoulder pain in last month	0.1	0.2	0.2	0.4	0.4	-0.5
Medication: Blood pressure	0.3	0.6	1.5	1.2	0.3	-0.5
Angina (self-reported)	0.1	0.1	0.2	0.5	-0.0	0.2
Migraine (self-reported)	0.8	1.1	3.0	-0.3	-1.7	0.3
Medication: Ibuprofen	2.4	2.8	7.7	0.3	0.8	-2.8
Medication: Allopurinol	1.2	1.6	3.2	-0.9	-0.8	1.8
Medication: Omeprazole	0.2	0.2	0.5	-0.3	-0.2	0.7
Medication: Seretide 50 evohaler	0.4	0.4	1.2	1.1	-0.0	-0.2
Mean time to correctly identify matches	0.0	0.1	0.1	0.0	-0.3	-0.3
Heart disease (mother)	0.0	0.0	0.1	0.1	0.1	0.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.1	0.2	0.4	0.1	-0.6	-0.3
Whole body fat mass	0.2	0.8	2.1	0.3	-0.5	-1.4
Leg fat mass (right)	0.2	0.8	2.1	0.5	0.0	-1.4
Arm predicted mass (right)	1.6	8.1	17.8	-2.5	-4.2	-0.3
Pulse rate, automated reading	1.7	5.5	7.6	2.8	2.0	-2.2
Alcohol intake frequency.	0.1	0.3	0.9	0.9	-0.1	-0.3
Comparative height size at age 10	3.7	20.3	33.8	-5.2	-5.8	-0.5
Number of full sisters	0.4	0.5	0.7	-0.8	0.8	0.5
Suffer from ‘nerves’	0.3	0.5	1.4	1.2	0.0	-0.3
Overall health rating	2.4	5.1	10.9	3.3	1.9	0.9
Chest pain or discomfort	0.8	1.1	1.8	1.3	0.2	-1.2
Had major operations	0.6	0.7	1.1	0.2	1.1	0.9
Age at last live birth	0.5	0.7	1.7	-1.3	-0.4	-0.6
Family relationship satisfaction	0.5	0.6	0.9	1.0	-0.9	0.4
Leg pain on walking	1.5	1.9	3.4	1.8	1.1	-1.1
Qualifications: NVQ or HND or HNC or equivalent	1.0	1.2	3.0	0.7	1.7	0.3
Commuting to job workplace: Car/motor vehicle	0.6	0.7	1.7	0.7	1.3	0.0
Illness, injury, bereavement, stress in last 2 years	1.9	2.3	4.2	-1.6	-0.6	-2.0
Medication: Aspirin	0.1	0.2	0.5	-0.1	-0.1	-0.7
Supplements: Vitamin C	1.3	1.5	3.5	1.9	0.9	0.5
Knee pain experienced in last month	0.4	0.6	1.3	1.1	0.7	-0.3
Hypertension (Self-reported)	0.1	0.2	0.5	0.7	0.3	-0.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.4	0.4	0.7	0.8	-0.7	-0.4
Illnesses of father: Heart disease	2.7	3.8	6.6	1.9	-0.9	-2.6
Illnesses of siblings: Diabetes	1.1	1.4	2.3	-1.0	-1.5	0.9
Smoking status: Previous	0.1	0.1	0.2	-0.1	0.2	0.5
Forced expiratory volume in 1-second (FEV1), predicted	1.6	3.3	6.7	-1.8	-2.6	-0.1
Whole body fat-free mass	1.7	10.0	21.7	-2.8	-4.7	0.7
Leg fat-free mass (right)	1.1	6.0	14.4	-1.9	-3.8	0.2
Arm fat percentage (left)	0.6	2.2	3.3	1.8	1.5	-1.0
Average weekly red wine intake	0.4	0.6	1.2	-0.6	-1.1	-0.6
Handedness (chirality/laterality): Left-handed	0.5	0.6	1.4	-0.6	-1.2	0.3
Mood swings	0.7	1.2	2.9	-0.5	-1.7	-0.7
Loneliness, isolation	0.3	0.4	0.6	0.8	0.0	0.7
Long-standing illness, disability or infirmity	0.1	0.1	0.2	0.4	0.3	0.3
Ever had bowel cancer screening	0.6	0.7	1.7	-0.1	-1.3	-0.6
Diabetes diagnosed by doctor	2.2	3.6	4.6	2.1	1.8	-1.7
Ever had stillbirth, spontaneous miscarriage or termination	0.4	0.4	0.8	0.1	-0.7	-0.9
Friendships satisfaction	0.4	0.5	1.1	-1.0	-0.6	0.1
Qualifications: nursing, teaching	1.7	2.6	2.9	-1.6	-1.7	-1.6
Commuting to job workplace: Walk	0.3	0.3	0.8	0.2	0.9	-0.5
Eye problems/disorders: Cataract	1.0	1.2	2.0	-1.4	-0.9	-0.8
Mouth/teeth dental problems: Mouth ulcers	2.6	4.1	6.3	2.4	2.5	-0.6
Medication for cholesterol	0.7	1.1	3.1	-0.3	1.8	-0.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.2	0.3	0.6	-0.1	-0.4	-0.8
Back pain experienced in last month	0.5	0.7	1.7	1.3	0.6	0.2
Mineral and other dietary supplements	0.4	0.5	1.2	-1.1	0.3	-0.5
Breast cancer (self-reported)	0.3	0.3	0.8	-0.1	0.9	0.3
Asthma (self-reported)	0.4	0.7	1.6	1.2	0.6	-0.5
Osteoporosis (self-reported)	0.7	0.8	1.6	-1.3	-0.6	-0.7
Osteoarthritis (self-reported)	0.2	0.3	0.8	0.3	0.0	-0.9
Medication: Aspirin	0.1	0.2	0.5	0.1	-0.1	-0.7
Medication: Gliclazide	1.1	1.2	3.0	0.6	0.5	1.7
Illnesses of father: None of the above (group 1)	0.9	1.1	3.3	-0.1	0.2	1.8
Smoking status: Current	0.4	0.7	1.8	-0.3	-0.4	-1.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.3	2.7	3.7	1.8	1.9	1.0
Whole body water mass	1.7	9.9	21.9	-2.7	-4.7	0.7
Leg predicted mass (right)	1.1	6.1	14.4	-1.9	-3.8	0.2
Arm fat mass (left)	0.1	0.3	0.6	0.7	-0.2	-0.6
Number of self-reported non-cancer illnesses	1.7	3.0	4.9	-0.5	-2.2	-2.0
Average weekly champagne plus white wine intake	3.4	4.7	8.2	-2.1	-2.9	-1.2
Miserableness	0.3	0.5	0.8	-0.3	-0.9	0.8
Guilty feelings	0.9	1.4	3.8	0.2	-0.5	1.9
Wears glasses or contact lenses	0.8	0.9	1.3	1.1	1.0	-0.5
Ever taken oral contraceptive pill	0.8	0.9	1.6	-0.9	-1.3	-0.6
Hearing aid user	0.1	0.1	0.1	-0.4	0.1	0.1
Mother’s age at death	0.2	0.2	0.6	0.3	0.8	-0.2
Financial situation satisfaction	1.7	2.1	4.0	2.0	1.2	0.9
Tinnitus: Yes, now most or all of the time	0.3	0.3	0.9	-0.9	0.4	-0.1
Commuting to job workplace: Public transport	0.6	0.7	1.0	0.0	-1.0	1.0
Eye problems/disorders: Glaucoma	0.6	0.7	1.8	-1.3	-0.4	-0.2
Medication: Blood pressure	0.1	0.1	0.4	0.2	0.1	-0.6
Pain type(s) experienced in last month: Hip pain	0.7	0.9	1.0	0.9	1.0	-1.0
Supplements: Fish oil (including cod liver oil)	0.3	0.4	1.2	1.1	0.2	0.3
High cholesterol (Self-reported)	0.2	0.3	0.5	0.7	-0.2	0.5
Medication: Bendroflumethiazide	0.2	0.3	0.9	0.4	-0.9	-0.1
Medication: Paracetamol	0.1	0.1	0.1	0.3	0.4	0.2
Medication: Lisinopril	0.9	1.2	3.2	0.0	0.7	-1.8
Medication: Atorvastatin	0.4	0.5	0.6	0.8	-0.6	-0.7
Illnesses of father: High blood pressure	0.4	0.5	1.1	0.5	0.3	-1.1
Alcohol drinker status: Never	0.8	1.0	1.6	1.1	-1.3	-0.5
Ever smoked	0.6	1.1	3.0	-0.3	-1.7	0.3
Basal metabolic rate	1.4	7.5	16.7	-2.4	-4.1	0.5
Leg fat percentage (left)	0.8	2.9	3.4	1.9	1.6	-1.7
Arm fat-free mass (left)	1.4	7.0	17.0	-2.0	-4.1	0.1
Number of operations (self-reported)	0.5	0.8	1.7	-1.3	0.8	-0.2
Average weekly beer plus cider intake	1.8	2.5	5.1	1.6	2.3	-0.1
Irritability	0.7	1.3	2.0	-0.9	-1.4	0.9
Risk taking	0.1	0.1	0.3	-0.3	-0.2	0.5
Ever had prostate specific antigen (PSA) test	0.3	0.3	0.9	0.1	-0.3	0.9
Fractured/broken bones in last 5 years	0.2	0.3	0.5	-0.7	-0.7	-0.2
Age started oral contraceptive pill	0.5	0.6	1.3	-1.1	-0.7	-0.3
Diastolic blood pressure, automated reading	1.8	5.6	13.2	3.6	1.8	-0.4
Ever depressed for a whole week	0.0	0.0	0.1	0.1	0.3	-0.1
Unable to work because of sickness or disability	3.2	4.2	6.1	2.5	2.5	0.6
Commuting to job workplace: Cycle	2.7	3.3	5.9	-1.7	-2.4	1.0
Myopia	0.1	0.1	0.2	0.4	-0.1	0.1
Vascular/heart problems diagnosed by doctor	0.0	0.0	0.0	-0.1	-0.2	0.1
Cholesterol lowering medication	1.1	1.6	4.4	2.1	0.2	0.5
Medication: Omeprazole (e.g. Zanprol)	0.1	0.2	0.3	-0.6	0.0	0.5
Pain experienced in last month	0.3	0.6	1.1	0.0	0.7	1.1
Supplements: Calcium	0.7	0.8	1.9	0.4	-0.4	-1.4
Basal cell carcinoma (self-reported)	0.4	0.5	1.0	0.5	1.0	-0.4
Heart attack/myocardial infarction (self-reported)	0.5	0.6	0.9	0.9	0.9	0.4
Deep venous thrombosis (DVT) (self-reported)	0.4	0.5	1.1	-0.7	-0.2	1.1
Heart disease (siblings)	0.0	0.0	0.0	-0.2	-0.1	0.0
Alcohol drinker status: Previous	0.7	0.8	2.0	1.4	0.7	-0.1
Pack years of smoking	0.1	0.2	0.4	-0.5	-0.6	-0.0
Impedance of whole body	0.4	1.8	3.3	-1.3	0.5	-1.8
Leg fat mass (left)	0.2	1.0	2.3	0.8	-0.1	-1.5
Arm predicted mass (left)	1.5	7.9	18.6	-2.2	-4.3	0.4