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chr7:814,788-3,778,937

Best TWAS P=1.34e-246 · Best GWAS P=1.45e-248 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	AMZ1	0.19	0.12	enet	22	0.13	5.7e-16	17.06	18.2	3.5e-74	-0.44	1.00	0.00	TRUE
2	CommonMind	Brain Pre-frontal Cortex	GNA12	0.06	0.00	bslmm	603	0.02	3.7e-03	-0.64	11.2	4.1e-29	-0.44	0.12	0.10	TRUE
3	GTEx	Adipose Subcutaneous	GNA12	0.11	0.08	lasso	4	0.07	1.3e-06	-23.32	-24.3	3.9e-130	0.73	0.64	0.36	FALSE
4	GTEx	Adipose Subcutaneous	ELFN1	0.06	0.04	lasso	3	0.02	9.5e-03	8.24	8.0	1.6e-15	-0.06	0.01	0.94	FALSE
5	GTEx	Adipose Visceral Omentum	GNA12	0.28	0.06	enet	46	0.08	8.0e-05	14.99	-9.6	6.3e-22	0.38	0.11	0.74	FALSE
6	GTEx	Adrenal Gland	GNA12	0.33	-0.01	enet	41	0.10	1.6e-04	2.00	-8.2	2.4e-16	0.22	0.06	0.29	FALSE
7	GTEx	Artery Tibial	GNA12	0.24	0.13	enet	20	0.22	3.5e-17	-33.67	-30.8	9.1e-209	0.87	0.01	0.99	FALSE
8	GTEx	Brain Cortex	FTSJ2	0.17	0.01	enet	16	0.06	1.1e-02	-3.08	-5.3	1.1e-07	0.00	0.11	0.06	FALSE
9	GTEx	Breast Mammary Tissue (Male)	EIF3B	0.38	-0.01	enet	28	0.12	1.3e-03	20.00	-5.9	3.2e-09	0.06	0.04	0.07	FALSE
10	GTEx	Breast Mammary Tissue (Female)	GNA12	0.10	-0.01	enet	16	0.00	4.5e-01	-0.68	-5.2	2.2e-07	0.14	0.04	0.24	FALSE
11	GTEx	Cells EBV-transformed lymphocytes	GNA12	0.46	0.51	lasso	5	0.50	7.9e-19	-32.55	-32.6	1.6e-232	0.92	0.60	0.40	FALSE
12	GTEx	Cells Transformed fibroblasts	GNA12	0.21	0.11	lasso	11	0.15	1.7e-11	-33.58	-28.2	1.1e-174	0.89	0.02	0.98	FALSE
13	GTEx	Colon Sigmoid	GNA12	0.14	0.05	lasso	3	0.03	3.6e-02	-22.74	-29.4	3.5e-190	0.84	0.02	0.92	FALSE
14	GTEx	Colon Transverse	GNA12	0.19	0.08	lasso	4	0.10	2.3e-05	19.87	-22.3	3.0e-110	0.64	0.25	0.73	FALSE
15	GTEx	Esophagus Gastroesophageal Junction	GNA12	0.20	0.12	lasso	6	0.12	3.4e-05	-23.32	-29.1	3.3e-186	0.85	0.05	0.93	FALSE
16	GTEx	Esophagus Mucosa	GNA12	0.16	0.13	lasso	3	0.13	3.0e-09	-32.60	-31.1	1.1e-212	0.89	0.01	0.99	FALSE
17	GTEx	Esophagus Muscularis	MAD1L1	0.22	0.01	enet	40	0.05	5.6e-04	-1.97	-5.7	1.2e-08	-0.03	0.18	0.13	FALSE
18	GTEx	Esophagus Muscularis	GNA12	0.32	0.31	lasso	3	0.34	2.1e-21	-33.67	-32.9	2.2e-237	0.98	0.00	1.00	FALSE
19	GTEx	Esophagus Muscularis	AC004840.9	0.19	0.07	enet	34	0.10	1.2e-06	-2.75	5.6	1.8e-08	-0.23	0.47	0.06	TRUE
20	GTEx	Liver	AC004840.9	0.27	0.01	enet	27	0.06	7.0e-03	1.82	17.1	9.5e-66	-0.37	0.07	0.19	FALSE
21	GTEx	Lung	SNX8	0.14	0.01	lasso	6	0.04	4.1e-04	-3.28	8.8	1.1e-18	-0.29	0.25	0.14	FALSE
22	GTEx	Lung	GNA12	0.16	0.08	enet	21	0.12	1.2e-09	-32.51	-27.8	4.2e-170	0.77	0.02	0.98	TRUE
23	GTEx	Nerve Tibial	GNA12	0.31	0.34	lasso	7	0.36	9.6e-27	-23.11	-28.8	4.9e-182	0.85	0.86	0.14	FALSE
24	GTEx	Pituitary	INTS1	0.29	0.33	enet	8	0.20	9.1e-06	5.82	5.2	1.6e-07	-0.09	0.44	0.33	FALSE
25	GTEx	Prostate	MAFK	0.43	-0.01	enet	22	0.01	1.8e-01	8.12	-8.1	6.0e-16	0.02	0.02	0.57	TRUE
26	GTEx	Skin Not Sun Exposed Suprapubic	GNA12	0.10	0.15	lasso	3	0.12	4.2e-07	14.99	-17.3	2.7e-67	0.53	0.34	0.64	FALSE
27	GTEx	Skin Sun Exposed Lower leg	GNA12	0.17	0.16	lasso	3	0.18	1.3e-14	-22.48	-28.8	6.5e-182	0.88	0.07	0.93	FALSE
28	GTEx	Skin Sun Exposed Lower leg	AC004840.9	0.18	0.01	enet	36	0.02	3.7e-03	6.17	-9.8	7.8e-23	0.13	0.20	0.13	TRUE
29	GTEx	Small Intestine Terminal Ileum	GNA12	0.34	0.20	lasso	5	0.16	2.4e-04	-22.78	-23.5	2.0e-122	0.73	0.07	0.77	FALSE
30	GTEx	Stomach	GNA12	0.18	0.16	lasso	2	0.13	6.6e-07	-22.74	-22.8	4.0e-115	0.68	0.76	0.23	FALSE
31	GTEx	Testis	IQCE	0.47	0.00	enet	19	0.14	8.9e-07	-4.31	-5.3	9.3e-08	0.16	0.15	0.18	TRUE
32	GTEx	Thyroid	AC004840.9	0.11	0.10	enet	25	0.13	4.3e-10	-2.75	-5.7	1.4e-08	0.07	0.89	0.00	FALSE
33	GTEx	Uterus	INTS1	0.47	0.07	enet	22	0.05	4.1e-02	5.75	6.8	1.2e-11	-0.08	0.03	0.62	FALSE
34	GTEx	Whole Blood	GNA12	0.09	0.01	enet	4	0.00	3.3e-01	-32.17	-32.4	2.4e-230	0.95	0.02	0.91	FALSE
35	METSIM	Adipose	CARD11	0.05	0.01	blup	642	0.03	2.0e-05	1.57	5.4	8.4e-08	-0.19	0.40	0.03	FALSE
36	METSIM	Adipose	GNA12	0.07	0.05	lasso	3	0.05	3.3e-08	-22.78	-23.2	4.8e-119	0.74	0.28	0.72	FALSE
37	NTR	Blood	GNA12	0.07	0.03	bslmm	597	0.06	1.3e-17	-22.64	-20.6	3.5e-94	0.63	0.91	0.09	FALSE
38	ROSMAP	Brain Pre-frontal Cortex	SNX8	0.09	0.04	blup	452	0.05	1.2e-06	2.91	-6.7	1.8e-11	0.10	0.93	0.00	TRUE
39	ROSMAP	Brain Pre-frontal Cortex	GNA12	0.13	0.08	bslmm	585	0.08	5.3e-11	10.23	-5.8	6.8e-09	0.11	1.00	0.00	FALSE
40	ROSMAP	Brain Pre-frontal Cortex	AMZ1	0.09	0.05	lasso	6	0.04	2.4e-06	-33.67	33.5	1.3e-246	-0.95	0.00	1.00	TRUE
41	YFS	Blood	CHST12	0.04	0.00	enet	25	0.02	1.0e-06	-1.64	7.5	4.9e-14	-0.15	0.04	0.04	TRUE
42	YFS	Blood	GNA12	0.23	0.15	bslmm	570	0.25	4.5e-82	11.40	-18.1	2.1e-73	0.51	1.00	0.00	FALSE
43	YFS	Blood	SNX8	0.03	0.00	blup	442	0.02	6.6e-06	1.68	-5.5	2.9e-08	0.14	0.44	0.02	TRUE
44	YFS	Blood	TTYH3	0.02	0.01	lasso	4	0.01	2.6e-04	3.54	5.6	2.4e-08	-0.17	0.61	0.01	FALSE
45	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	TMEM184A	0.03	0.01	lasso	2	0.02	1.5e-02	8.15	8.0	1.9e-15	-0.05	0.01	0.73	FALSE
46	The Cancer Genome Atlas	Breast Invasive Carcinoma	TMEM184A	0.02	0.03	lasso	2	0.02	1.7e-05	6.35	7.2	8.9e-13	-0.05	0.02	0.98	FALSE
47	The Cancer Genome Atlas	Colon Adenocarcinoma	GNA12	0.09	0.00	blup	103	0.03	9.3e-03	-23.11	-14.7	4.5e-49	0.51	0.04	0.12	FALSE
48	The Cancer Genome Atlas	Colon Adenocarcinoma	TMEM184A	0.12	0.16	lasso	4	0.15	4.8e-09	7.79	7.8	9.5e-15	-0.05	0.03	0.97	FALSE
49	The Cancer Genome Atlas	Esophageal Carcinoma	AMZ1	0.18	0.05	blup	69	0.05	1.4e-02	18.79	-27.1	3.5e-161	0.74	0.01	0.71	FALSE
50	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	GNA12	0.03	0.04	lasso	1	0.04	3.0e-05	-23.32	-23.3	3.1e-120	0.70	0.08	0.76	FALSE
51	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	AMZ1	0.33	0.20	lasso	3	0.19	4.5e-11	6.85	6.6	3.5e-11	-0.26	1.00	0.00	FALSE
52	The Cancer Genome Atlas	Brain Lower Grade Glioma	AMZ1	0.04	0.04	lasso	3	0.02	1.3e-03	18.79	22.2	7.0e-109	-0.64	0.03	0.91	FALSE
53	The Cancer Genome Atlas	Lung Adenocarcinoma	GNA12	0.03	0.01	enet	7	0.02	1.5e-03	16.70	-28.0	9.3e-173	0.78	0.07	0.69	FALSE
54	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	AMZ1	0.14	0.06	enet	15	0.06	7.4e-08	6.85	12.6	4.0e-36	-0.33	0.84	0.04	FALSE
55	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	AMZ1	0.17	0.11	enet	9	0.10	5.0e-05	6.85	14.9	2.1e-50	-0.47	0.05	0.46	FALSE
56	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	INTS1	0.07	0.00	blup	46	0.01	1.8e-01	5.75	5.3	1.5e-07	-0.05	0.02	0.36	FALSE
57	The Cancer Genome Atlas	Prostate Adenocarcinoma	AMZ1	0.08	0.01	blup	71	0.05	1.3e-05	-23.32	19.2	2.7e-82	-0.64	0.06	0.71	FALSE
58	The Cancer Genome Atlas	Prostate Adenocarcinoma	TMEM184A	0.06	0.10	lasso	4	0.10	3.1e-10	8.15	7.8	5.0e-15	-0.04	0.01	0.99	FALSE
59	The Cancer Genome Atlas	Thyroid Carcinoma	AMZ1	0.32	0.04	enet	19	0.20	3.3e-19	-22.64	17.6	1.5e-69	-0.56	0.19	0.81	TRUE