Best TWAS P=9.71e-18 · Best GWAS P=2.29e-29 conditioned to 7.68e-27
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | PRTFDC1 | 0.12 | 0.03 | bslmm | 481 | 0.04 | 3.6e-05 | 6.4 | -7.7 | 1.3e-14 | -0.17 | 0.48 | 0.02 | TRUE |
| 2 | GTEx | Artery Tibial | PIP4K2A | 0.06 | 0.01 | enet | 8 | 0.02 | 2.1e-02 | 5.7 | -5.3 | 9.5e-08 | -0.02 | 0.12 | 0.51 | FALSE |
| 3 | GTEx | Cells Transformed fibroblasts | PIP4K2A | 0.24 | 0.20 | lasso | 2 | 0.19 | 2.9e-14 | 5.7 | -5.6 | 2.1e-08 | 0.01 | 0.83 | 0.17 | FALSE |
| 4 | GTEx | Nerve Tibial | OTUD1 | 0.07 | 0.04 | enet | 12 | 0.03 | 5.2e-03 | 5.3 | 5.5 | 3.2e-08 | -0.08 | 0.15 | 0.44 | FALSE |
| 5 | GTEx | Testis | THNSL1 | 0.14 | 0.22 | lasso | 1 | 0.22 | 5.3e-10 | 6.3 | 6.3 | 2.6e-10 | 0.05 | 0.91 | 0.08 | FALSE |
| 6 | METSIM | Adipose | PIP4K2A | 0.04 | 0.00 | bslmm | 324 | 0.01 | 4.0e-02 | 4.9 | -5.7 | 1.4e-08 | -0.02 | 0.05 | 0.69 | TRUE |
| 7 | ROSMAP | Brain Pre-frontal Cortex | ENKUR | 0.05 | 0.03 | blup | 418 | 0.02 | 3.4e-03 | -5.1 | -8.3 | 7.9e-17 | -0.03 | 0.22 | 0.03 | TRUE |
| 8 | ROSMAP | Brain Pre-frontal Cortex | THNSL1 | 0.08 | 0.06 | blup | 393 | 0.07 | 6.6e-09 | 5.8 | 5.3 | 1.5e-07 | 0.10 | 1.00 | 0.00 | FALSE |
| 9 | YFS | Blood | ARHGAP21 | 0.05 | 0.04 | enet | 35 | 0.05 | 9.5e-15 | -6.2 | -5.9 | 3.5e-09 | -0.14 | 1.00 | 0.00 | FALSE |
| 10 | The Cancer Genome Atlas | Liver Hepatocellular Carcinoma | OTUD1 | 0.11 | 0.07 | lasso | 2 | 0.06 | 5.7e-04 | 8.5 | -8.6 | 9.7e-18 | 0.06 | 0.00 | 0.94 | TRUE |
| 11 | The Cancer Genome Atlas | Liver Hepatocellular Carcinoma | THNSL1 | 0.07 | 0.03 | lasso | 2 | 0.03 | 1.6e-02 | 5.8 | 6.3 | 3.9e-10 | 0.08 | 0.07 | 0.35 | FALSE |