Hub : Genes

OTUD1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Nerve Tibial 0.0657 0.0292 0.0015 0.043 NA 0.027 NA 0.025 0.00048 NA 0.0052 NA 0.00620
2 TCGA Liver Hepatocellular Carcinoma 0.1120 0.0730 0.0024 0.070 0.036 0.043 NA 0.064 0.00032 0.0084 0.0042 NA 0.00057

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bipolar Disorder (2018) 0.0 0.0 0.1 0.2 -0.2
Bipolar Disorder or Schizophrenia 0.5 1.2 2.4 -0.2 -1.5
Depressed Affect (Nagel 2018) 1.0 2.1 2.4 1.3 -1.5
Depression (Nagel 2018) 0.4 0.6 0.8 -0.9 0.6
Intelligence (Savage-Jansen 2018) 0.8 2.5 3.4 -1.8 -1.3
Neuroticism (Nagel 2018) 0.9 2.2 3.2 1.8 -1.0
Schizophrenia (2018) 0.8 1.7 3.3 -0.4 -1.8
Schizophrenia vs Biploar Disorder 1.4 1.9 2.0 1.3 -1.4
Worry (Nagel 2018) 0.3 0.6 1.2 1.1 0.1
Alzheimer’s Disease (in mother) 0.5 0.5 0.5 -0.7 0.7
Alzheimer’s Disease (in father) 0.4 0.5 0.5 0.7 0.7
Alzheimer’s Disease (including proxy) 0.6 0.8 1.6 -0.2 1.3
Crohns Disease (2017) 0.1 0.3 0.4 0.4 0.7
Irritable Bowel Disease (IBD) 0.7 1.6 2.9 -0.6 1.7
Ulcerative Colitis (UC) 1.6 2.9 4.1 -1.3 2.0
Major Depression (MDD) 0.1 0.2 0.3 0.5 0.3
Reaction Time 0.1 0.3 0.3 -0.6 0.4
Verbal and Numeric Reasoning (VNR) 1.1 2.6 4.4 -0.9 -2.1
Breast Cancer 0.6 1.5 3.0 -0.2 1.7
Ovarian Cancer 0.3 0.3 0.6 0.8 0.3
Prostate Cancer 1.7 2.4 4.3 0.7 -2.1
Age at First Birth 0.5 0.7 1.0 -1.0 0.6
Bipolar Disorder (2011) 0.5 0.5 1.1 -1.0 0.0
Body Mass Index (BMI) (2010) 0.9 1.2 2.3 -1.5 0.4
Coronary Artery Disease (CAD) 0.3 0.3 0.4 -0.6 -0.6
Crohns Disease (2012) 1.5 2.3 3.8 2.0 -0.9
Mean Putamen Volume 0.3 0.3 0.7 -0.0 -0.8
Fasting Glucose 0.5 0.6 0.6 -0.8 -0.8
HbA1C 3.4 3.8 6.9 0.8 -2.6
HDL Cholesterol 0.4 0.7 0.7 0.9 -0.8
LDL Cholesterol 1.4 2.2 3.6 -1.9 0.9
Lupus 0.2 0.4 0.6 0.4 -0.8
Neuroticism (2016) 1.3 1.9 3.3 1.8 -0.7
Primary Biliary Cirrhosis 0.8 1.2 2.0 -1.4 0.6
Rheumatoid Arthritis 0.0 0.0 0.1 -0.0 -0.3
Schizophrenia (2014) 0.5 1.1 2.0 0.4 -1.4
Triglycerides 0.3 0.4 0.8 0.2 -0.9
Type 2 Diabetes (T2D) (2012) 0.2 0.3 0.5 0.7 0.2
Ulcerative Colitis 0.3 0.4 0.8 -0.2 0.9
Blood Eosinophil Count 0.3 2.3 4.5 0.3 -2.1
Blood Platelet Count 0.2 1.8 2.5 -1.6 1.0
Blood Red Count 1.1 11.0 19.2 -1.7 4.4
Blood White Count 0.3 2.5 3.6 -1.2 1.9
Heel T-Score 0.7 5.2 10.0 0.6 -3.2
BMI 0.3 1.6 2.6 0.8 -1.6
Height 2.7 52.1 73.6 5.5 -8.6
Waist Hip Ratio (WHR) 0.2 1.1 2.1 0.0 -1.4
Systolic Blood Pressure 0.6 3.2 3.3 1.7 1.8
Smoking Status 2.5 6.0 6.6 2.3 -2.6
Allergy or Eczema 0.8 2.2 3.7 -1.9 0.9
Cardiovascular Disease 1.3 4.2 7.1 -1.1 2.7
Hypothyroidism (self reported) 0.5 1.2 2.3 0.3 -1.5
Respiratory disease 0.4 1.0 1.8 0.3 -1.4
Type 2 Diabetes (T2D) (2018) 0.3 0.5 0.7 0.6 -0.8
Lung FEV1/FVC ratio 2.0 10.4 11.8 -3.4 3.0
Lung FVC 0.2 0.8 0.9 0.8 0.9
Neuroticism 0.6 1.4 2.6 1.6 -0.4
Chronotype (morning person) 0.2 0.4 0.7 0.8 -0.4
Hair Pigment 0.0 0.6 1.2 1.1 0.1
Tanning 0.0 0.1 0.3 0.5 0.1
Hand grip strength (left) 0.7 2.0 3.9 0.1 -2.0
Number of treatments/medications taken 1.1 2.1 2.5 -1.6 1.3
Average weekly spirits intake 0.7 0.9 1.0 -1.0 0.9
Sensitivity / hurt feelings 0.2 0.3 0.4 0.7 -0.4
Frequency of depressed mood in last 2 weeks 0.4 0.6 1.1 -0.3 1.1
Hearing difficulty/problems: Yes 2.1 3.2 5.4 1.0 -2.3
Relative age of first facial hair 1.8 3.7 4.4 -2.1 1.7
Other serious medical condition/disability diagnosed by doctor 0.1 0.1 0.3 0.0 0.5
Ever used hormone-replacement therapy (HRT) 0.0 0.0 0.0 -0.0 -0.1
Ever had hysterectomy (womb removed) 0.5 0.6 1.2 -0.0 1.1
Systolic blood pressure, automated reading 0.5 1.4 2.0 0.9 1.4
Eye problems/disorders: Diabetes related eye disease 0.2 0.2 0.3 -0.3 0.6
Angina 2.0 2.6 4.1 -2.0 1.0
Medication for hormone replacement therapy 0.3 0.3 0.6 0.1 -0.8
Vitamin and mineral supplements 1.3 1.8 2.1 -1.2 1.4
Supplements: Zinc 2.3 2.5 2.7 1.5 -1.6
Medication: Co-codamol 1.4 1.6 3.2 0.2 -1.8
Medication: Metformin 0.9 1.3 2.6 -0.2 1.6
Diabetes (father) 0.4 0.5 1.0 -1.0 -0.2
Diabetes (mother) 0.8 1.1 1.4 0.9 -1.2
Severe depression (siblings) 3.4 3.8 4.5 1.8 -2.1
Pack years adult smoking proportion 0.3 0.4 0.6 0.5 -0.8
Impedance of leg (right) 0.0 0.2 0.2 0.5 -0.4
Leg fat-free mass (left) 1.8 9.3 13.6 2.3 -3.7
Trunk fat percentage 1.6 6.2 10.0 1.5 -3.2
Hand grip strength (right) 0.4 1.0 2.0 0.1 -1.4
Townsend deprivation index at recruitment 0.5 0.8 1.0 0.7 -1.0
Current tobacco smoking 1.0 1.6 2.0 1.1 -1.4
Average weekly fortified wine intake 0.5 0.6 1.2 -0.1 -1.1
Maternal smoking around birth 2.1 3.1 4.5 2.1 -1.3
Fed-up feelings 2.4 4.3 4.5 2.1 -2.0
Frequency of unenthusiasm / disinterest in last 2 weeks 0.0 0.0 0.1 0.1 0.3
Relative age voice broke 2.3 3.6 5.6 -2.4 1.2
Taking other prescription medications 0.6 0.9 1.6 -1.3 -0.3
Age when periods started (menarche) 1.1 2.7 3.3 -1.8 1.5
Bilateral oophorectomy (both ovaries removed) 0.1 0.1 0.1 -0.3 0.1
Heel bone mineral density (BMD) T-score, automated (left) 0.6 1.3 2.6 -0.3 -1.6
Tinnitus: Yes, but not now, but have in the past 0.1 0.2 0.3 -0.2 0.5
Qualifications: CSEs or equivalent 0.6 0.8 1.7 1.3 0.0
Serious illness, injury or assault to yourself 0.0 0.0 0.1 -0.2 -0.1
High blood pressure 0.4 1.1 2.1 -0.3 1.4
Hayfever, allergic rhinitis or eczema 0.0 0.1 0.1 -0.2 0.4
Multivitamins +/- minerals 0.1 0.1 0.2 -0.2 -0.4
Stomach or abdominal pain in last month 0.6 0.8 1.4 0.4 -1.2
Supplements: Glucosamine 0.4 0.5 0.7 0.5 -0.8
Diverticular disease/diverticulitis (self-reported) 0.1 0.1 0.1 0.3 -0.2
Medication: Atenolol 0.5 0.6 1.2 0.0 1.1
Medication: Levothyroxine sodium 0.3 0.5 0.9 0.4 -0.9
Sitting height 4.5 32.1 37.6 6.1 -5.2
Chronic bronchitis/emphysema (father) 0.1 0.1 0.1 0.3 -0.3
High blood pressure (mother) 1.3 1.8 2.5 -1.6 1.0
Body mass index (BMI) 0.2 0.9 1.7 -0.0 -1.3
Impedance of leg (left) 0.0 0.1 0.2 0.4 -0.0
Leg predicted mass (left) 1.7 9.0 13.1 2.2 -3.6
Trunk fat mass 2.5 10.6 16.7 2.1 -4.1
Waist circumference 1.2 4.3 8.1 0.7 -2.8
Number of incorrect matches in round 0.3 0.5 0.7 -0.5 -0.8
Past tobacco smoking 0.9 1.7 1.7 -1.3 1.3
Alcohol usually taken with meals 1.8 3.0 3.8 -1.4 2.0
Nervous feelings 0.1 0.2 0.2 0.4 0.5
Frequency of tenseness / restlessness in last 2 weeks 0.1 0.1 0.2 -0.5 -0.0
Hearing difficulty/problems with background noise 1.3 2.0 2.2 1.4 -1.5
Hair/balding pattern: Pattern 2 0.5 0.6 1.1 -1.0 0.4
Had menopause 0.2 0.3 0.5 0.7 -0.2
Had other major operations 2.1 2.5 3.4 1.3 -1.9
Forced vital capacity (FVC) 1.7 6.6 12.6 3.5 -0.7
Heel bone mineral density (BMD) T-score, automated (right) 0.6 1.4 2.6 0.3 -1.6
Ever unenthusiastic/disinterested for a whole week 0.5 0.6 1.2 -0.3 1.1
Qualifications: None of the above 0.5 1.1 1.6 0.7 -1.3
Financial difficulties in last 2 years 4.1 5.6 6.6 2.6 -2.1
Mouth/teeth dental problems 1.1 1.7 2.6 -0.9 1.6
Heart attack 0.2 0.2 0.4 0.0 0.6
Allergy 0.0 0.0 0.1 0.1 -0.3
Pain all over the body in last month 1.7 1.9 2.0 1.3 -1.4
Diabetes (self-reported) 0.8 1.2 1.4 -1.0 1.2
Hayfever/allergic rhinitis (self-reported) 0.4 0.6 1.1 -0.0 1.1
Medication: Ramipril 1.1 1.4 2.3 -0.7 1.5
Medication: Simvastatin 3.9 5.7 6.5 -2.5 2.2
Fluid intelligence score 1.3 2.6 3.7 -1.2 -1.9
Illnesses of siblings 0.4 0.5 0.8 0.9 0.6
Neuroticism score 0.6 1.3 2.3 1.5 -0.4
Weight 2.0 9.7 15.3 2.0 -3.9
Impedance of arm (right) 0.2 0.8 1.5 1.2 -0.2
Arm fat percentage (right) 0.4 1.5 2.7 0.6 -1.6
Trunk fat-free mass 1.8 10.5 15.8 2.2 -4.0
Hip circumference 1.3 5.5 8.4 1.6 -2.9
Time employed in main current job 0.7 0.8 1.6 -1.3 0.3
Alcohol intake versus 10 years previously 0.1 0.1 0.3 0.5 0.1
Father’s age at death 2.3 3.1 3.6 1.6 -1.9
Worrier / anxious feelings 0.4 0.7 1.4 1.2 0.2
Frequency of tiredness / lethargy in last 2 weeks 1.0 1.7 3.4 -0.1 -1.8
Falls in the last year 1.1 1.5 2.9 -1.7 -0.1
Hair/balding pattern: Pattern 3 0.3 0.4 0.6 0.8 -0.4
Number of live births 0.1 0.2 0.3 0.5 -0.2
Forced expiratory volume in 1-second (FEV1) 0.6 2.0 3.9 2.0 0.3
Pulse rate 0.2 0.3 0.5 0.3 -0.7
Happiness 0.7 0.8 1.0 1.0 0.8
Noisy workplace 1.0 1.2 1.5 1.2 1.0
Qualifications: A levels/AS levels or equivalent 1.0 2.2 2.4 -1.4 1.5
Serious illness, injury or assault of a close relative in last 2 years 0.8 0.9 1.7 1.3 -0.5
Mouth/teeth dental problems: Dentures 0.3 0.5 0.9 0.2 -1.0
Asthma 0.0 0.0 0.0 0.1 -0.1
Medication: Ibuprofen (e.g. Nurofen) 0.1 0.2 0.2 -0.4 0.4
Medication: Cholesterol lowering 6.0 9.4 9.5 -3.1 3.1
Depression (self-reported) 1.1 1.3 1.4 1.1 -1.2
Medication: Lansoprazole 1.7 1.9 2.6 -1.6 1.1
Prospective memory result 0.3 0.4 0.4 -0.7 -0.6
Lung cancer (father) 0.5 0.6 1.1 0.0 1.1
Illnesses of mother 1.0 1.3 1.4 1.2 -1.0
Forced expiratory volume in 1-second (FEV1), Best measure 0.6 2.1 3.8 1.9 0.6
Pulse wave Arterial Stiffness index 0.5 0.5 1.0 -1.0 0.2
Impedance of arm (left) 0.3 1.4 2.8 1.7 -0.1
Arm fat mass (right) 1.0 4.2 6.8 1.2 -2.6
Trunk predicted mass 1.8 10.3 15.6 2.2 -4.0
Standing height 3.2 32.1 38.3 5.1 -6.2
Length of working week for main job 0.6 0.7 1.4 -0.2 -1.2
Exposure to tobacco smoke at home 0.2 0.2 0.4 0.3 -0.6
Breastfed as a baby 0.9 1.1 1.4 -0.9 1.2
Tense / ‘highly strung’ 0.4 0.7 0.9 0.9 -0.7
Seen doctor (GP) for nerves, anxiety, tension or depression 0.6 1.0 1.9 1.4 0.2
Hair/balding pattern: Pattern 4 0.0 0.0 0.0 -0.2 0.2
Birth weight of first child 0.5 0.9 1.9 0.1 1.4
Peak expiratory flow (PEF) 0.1 0.2 0.3 0.5 -0.1
Pulse wave reflection index 2.3 2.9 4.6 -2.1 1.1
Ever highly irritable/argumentative for 2 days 1.2 1.4 2.4 1.5 -0.7
Loud music exposure frequency 4.1 4.5 6.7 2.6 -1.5
Qualifications: O levels/GCSEs or equivalent 0.1 0.2 0.4 0.7 0.2
Mouth/teeth dental problems: Bleeding gums 2.7 3.5 4.8 1.5 -2.2
Blood clot in the leg (DVT) 1.6 2.1 3.8 -2.0 0.5
Medication: Paracetamol 0.0 0.0 0.0 -0.2 -0.1
Headache pain in last month 4.3 7.4 8.4 -2.5 2.9
Medication for cholesterol, blood pressure or diabetes 3.5 5.8 6.9 2.6 -2.2
Glaucoma (self-reported) 0.1 0.1 0.1 0.3 0.3
Gout (self-reported) 2.2 3.1 5.7 2.4 -0.7
Hypothyroidism/myxoedema (self-reported) 1.0 2.0 2.5 1.3 -1.6
Medication: Amlodipine 0.3 0.4 0.8 -0.0 0.9
Medication: Ventolin 100micrograms inhaler 0.3 0.4 0.7 -0.9 -0.3
Birth weight 0.0 0.0 0.1 -0.2 -0.2
Chronic bronchitis/emphysema (mother) 0.5 0.5 0.8 0.9 -0.5
High blood pressure (siblings) 1.0 1.4 2.4 -1.5 -0.7
Forced vital capacity (FVC), Best measure 1.6 5.9 11.2 3.3 -0.7
Body fat percentage 0.9 3.5 6.5 0.7 -2.5
Leg fat percentage (right) 0.6 2.3 4.5 -0.4 -2.1
Arm fat-free mass (right) 2.0 10.2 15.7 2.2 -4.0
Exposure to tobacco smoke outside home 0.3 0.5 0.9 -0.9 0.2
Comparative body size at age 10 0.3 0.8 0.8 -0.9 0.9
Number of full brothers 0.3 0.4 0.8 -0.9 -0.0
Worry too long after embarrassment 1.1 1.9 3.8 -0.1 2.0
Seen a psychiatrist for nerves, anxiety, tension or depression 0.3 0.4 0.5 0.7 0.5
Wheeze or whistling in the chest in last year 0.0 0.0 0.0 0.2 -0.2
Number of children fathered 4.4 4.9 9.6 0.5 -3.1
Reason for reducing amount of alcohol drunk: Health precaution 0.3 0.4 0.6 -0.8 -0.4
Age at first live birth 0.1 0.2 0.2 -0.5 -0.5
Pulse wave peak to peak time 1.0 1.1 1.8 1.4 -0.7
Health satisfaction 0.3 0.4 0.8 -0.1 0.9
Shortness of breath walking on level ground 0.3 0.4 0.5 -0.7 -0.5
Qualifications: College or University degree 2.1 6.8 9.8 -3.1 1.9
Eye problems/disorders: None of the above 0.2 0.2 0.4 -0.6 0.3
Mouth/teeth dental problems: Loose teeth 2.1 2.5 4.5 -2.1 0.8
Emphysema/chronic bronchitis 0.4 0.5 0.8 -0.9 0.4
Medication for pain relief, constipation, heartburn 1.0 1.7 2.8 1.7 -0.8
Neck or shoulder pain in last month 0.1 0.2 0.3 -0.5 -0.2
Medication: Blood pressure 2.2 3.9 4.8 -2.2 1.7
Angina (self-reported) 2.3 3.0 5.0 -2.2 1.0
Migraine (self-reported) 0.7 0.9 1.1 -1.1 0.8
Medication: Ibuprofen 0.1 0.2 0.2 -0.3 0.5
Medication: Allopurinol 0.7 1.0 1.9 1.4 -0.2
Medication: Omeprazole 0.7 0.8 1.6 -1.3 0.2
Medication: Seretide 50 evohaler 0.1 0.1 0.2 0.4 -0.1
Mean time to correctly identify matches 0.6 1.1 2.1 -1.4 0.3
Heart disease (mother) 0.5 0.6 0.6 -0.8 0.8
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.2 0.2 0.3 0.5 0.4
Whole body fat mass 1.5 6.3 10.8 1.4 -3.3
Leg fat mass (right) 0.9 3.7 6.8 0.7 -2.6
Arm predicted mass (right) 1.8 9.0 14.4 1.9 -3.8
Pulse rate, automated reading 0.5 1.6 2.3 1.5 -0.9
Alcohol intake frequency. 1.6 3.7 5.8 -2.4 1.3
Comparative height size at age 10 4.3 23.7 33.2 3.8 -5.8
Number of full sisters 0.3 0.4 0.6 0.4 -0.8
Suffer from ‘nerves’ 0.4 0.6 1.2 0.3 1.1
Overall health rating 0.6 1.2 2.4 1.6 -0.1
Chest pain or discomfort 0.1 0.1 0.2 0.3 0.4
Had major operations 2.0 2.4 4.7 -2.2 -0.1
Age at last live birth 0.2 0.3 0.6 0.0 0.8
Family relationship satisfaction 0.6 0.8 1.5 -0.3 1.2
Leg pain on walking 0.8 1.0 2.0 -1.4 0.3
Qualifications: NVQ or HND or HNC or equivalent 0.4 0.5 0.9 0.1 -1.0
Commuting to job workplace: Car/motor vehicle 0.2 0.2 0.4 -0.2 0.6
Illness, injury, bereavement, stress in last 2 years 0.6 0.7 1.5 0.2 1.2
Medication: Aspirin 1.4 1.9 2.4 -1.1 1.6
Supplements: Vitamin C 2.0 2.3 2.4 1.5 -1.5
Knee pain experienced in last month 1.5 2.3 3.2 -1.2 -1.8
Hypertension (Self-reported) 0.5 1.4 2.8 -0.2 1.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.9 1.1 1.7 -1.3 0.7
Illnesses of father: Heart disease 0.3 0.4 0.4 0.7 -0.6
Illnesses of siblings: Diabetes 0.1 0.1 0.3 -0.1 -0.5
Smoking status: Previous 1.2 1.8 2.5 1.6 -1.1
Forced expiratory volume in 1-second (FEV1), predicted 0.3 0.6 1.1 1.0 -0.3
Whole body fat-free mass 1.8 10.1 15.3 2.2 -3.9
Leg fat-free mass (right) 1.5 7.9 11.0 2.2 -3.3
Arm fat percentage (left) 0.3 1.4 2.3 0.6 -1.5
Average weekly red wine intake 0.1 0.1 0.2 -0.5 -0.2
Handedness (chirality/laterality): Left-handed 1.3 1.6 2.1 1.1 -1.4
Mood swings 1.8 3.3 4.7 1.4 -2.2
Loneliness, isolation 0.0 0.0 0.0 0.1 -0.2
Long-standing illness, disability or infirmity 0.0 0.1 0.1 0.3 0.1
Ever had bowel cancer screening 1.5 1.7 2.6 -0.9 -1.6
Diabetes diagnosed by doctor 0.6 1.0 1.2 -0.9 1.1
Ever had stillbirth, spontaneous miscarriage or termination 0.4 0.4 0.5 -0.7 0.5
Friendships satisfaction 1.5 1.9 3.6 1.9 -0.4
Qualifications: nursing, teaching 1.3 2.0 2.8 -1.7 1.1
Commuting to job workplace: Walk 0.8 0.9 1.5 -1.2 -0.6
Eye problems/disorders: Cataract 0.3 0.4 0.8 -0.1 -0.9
Mouth/teeth dental problems: Mouth ulcers 0.1 0.1 0.2 0.4 0.3
Medication for cholesterol 0.9 1.3 1.9 0.9 -1.4
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.2 0.2 0.3 -0.4 -0.5
Back pain experienced in last month 0.7 1.1 1.9 -0.4 -1.4
Mineral and other dietary supplements 2.2 2.9 3.0 -1.7 1.7
Breast cancer (self-reported) 1.9 2.2 4.5 0.2 -2.1
Asthma (self-reported) 0.0 0.1 0.1 0.2 -0.3
Osteoporosis (self-reported) 2.5 3.1 4.1 2.0 -1.5
Osteoarthritis (self-reported) 5.6 7.3 14.2 0.6 -3.8
Medication: Aspirin 1.5 1.9 2.0 -1.3 1.4
Medication: Gliclazide 3.1 3.5 5.4 -1.3 2.3
Illnesses of father: None of the above (group 1) 0.1 0.1 0.2 0.2 0.4
Smoking status: Current 1.0 1.5 2.5 0.8 -1.6
Forced expiratory volume in 1-second (FEV1), predicted percentage 1.3 2.7 5.1 -0.6 2.3
Whole body water mass 1.8 10.0 15.1 2.2 -3.9
Leg predicted mass (right) 1.5 7.8 10.6 2.2 -3.2
Arm fat mass (left) 1.0 3.9 6.1 1.3 -2.5
Number of self-reported non-cancer illnesses 0.0 0.1 0.1 -0.0 0.3
Average weekly champagne plus white wine intake 0.1 0.1 0.1 0.4 0.2
Miserableness 2.4 4.1 4.5 2.1 -2.0
Guilty feelings 0.5 0.8 1.6 1.3 -0.2
Wears glasses or contact lenses 1.6 1.9 1.9 -1.4 1.3
Ever taken oral contraceptive pill 0.6 0.6 1.0 1.0 -0.5
Hearing aid user 2.2 2.5 2.6 1.5 -1.6
Mother’s age at death 0.2 0.3 0.4 -0.7 0.4
Financial situation satisfaction 0.9 1.1 1.8 1.4 0.7
Tinnitus: Yes, now most or all of the time 0.4 0.5 1.0 1.0 -0.0
Commuting to job workplace: Public transport 1.1 1.4 2.7 -1.6 0.1
Eye problems/disorders: Glaucoma 0.3 0.3 0.7 0.8 -0.1
Medication: Blood pressure 0.4 0.7 1.3 0.4 1.2
Pain type(s) experienced in last month: Hip pain 0.2 0.3 0.4 -0.6 -0.4
Supplements: Fish oil (including cod liver oil) 2.9 3.8 4.2 1.9 -2.0
High cholesterol (Self-reported) 4.5 8.0 10.5 -3.2 2.4
Medication: Bendroflumethiazide 0.5 0.7 1.3 0.4 1.1
Medication: Paracetamol 0.3 0.5 0.9 -0.9 0.4
Medication: Lisinopril 0.2 0.3 0.5 -0.2 0.7
Medication: Atorvastatin 0.4 0.5 1.0 -1.0 -0.2
Illnesses of father: High blood pressure 0.2 0.2 0.4 -0.6 -0.1
Alcohol drinker status: Never 0.4 0.5 0.7 0.8 -0.6
Ever smoked 1.8 3.1 4.7 2.2 -1.2
Basal metabolic rate 1.8 9.8 15.0 2.1 -3.9
Leg fat percentage (left) 0.5 1.9 3.7 -0.3 -1.9
Arm fat-free mass (left) 1.9 9.8 16.7 1.7 -4.1
Number of operations (self-reported) 0.2 0.3 0.6 -0.2 -0.8
Average weekly beer plus cider intake 0.6 0.9 1.4 1.2 -0.6
Irritability 0.8 1.3 2.7 0.1 -1.6
Risk taking 3.9 5.6 8.6 1.6 -2.9
Ever had prostate specific antigen (PSA) test 0.2 0.2 0.3 -0.4 0.5
Fractured/broken bones in last 5 years 0.3 0.3 0.6 0.2 0.8
Age started oral contraceptive pill 0.5 0.6 0.8 0.6 -0.9
Diastolic blood pressure, automated reading 0.2 0.7 1.4 0.1 1.2
Ever depressed for a whole week 0.6 0.7 1.0 -0.6 1.0
Unable to work because of sickness or disability 2.2 2.9 3.8 -1.9 1.4
Commuting to job workplace: Cycle 1.0 1.2 1.7 1.3 -0.8
Myopia 0.5 0.8 1.6 0.1 1.2
Vascular/heart problems diagnosed by doctor 0.7 1.8 3.2 0.6 -1.8
Cholesterol lowering medication 1.0 1.5 1.7 -1.3 1.2
Medication: Omeprazole (e.g. Zanprol) 0.9 1.1 2.1 -1.5 0.3
Pain experienced in last month 0.9 1.4 1.8 1.1 1.3
Supplements: Calcium 4.2 4.6 8.1 2.9 -1.0
Basal cell carcinoma (self-reported) 0.2 0.2 0.3 -0.3 -0.6
Heart attack/myocardial infarction (self-reported) 0.2 0.2 0.3 0.5 0.4
Deep venous thrombosis (DVT) (self-reported) 1.2 1.6 2.8 -1.7 0.7
Heart disease (siblings) 0.0 0.0 0.0 -0.0 -0.2
Alcohol drinker status: Previous 3.0 3.4 6.8 -2.6 0.1
Pack years of smoking 0.3 0.4 0.6 0.3 -0.8
Impedance of whole body 0.2 0.9 1.8 1.3 -0.3
Leg fat mass (left) 1.0 3.7 6.7 0.9 -2.6
Arm predicted mass (left) 1.9 9.7 16.3 1.8 -4.0