TWAS hub - OTUD1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Nerve Tibial	0.0657	0.0292	0.0015	0.043	NA	0.027	NA	0.025	0.00048	NA	0.0052	NA	0.00620
2	TCGA	Liver Hepatocellular Carcinoma	0.1120	0.0730	0.0024	0.070	0.036	0.043	NA	0.064	0.00032	0.0084	0.0042	NA	0.00057

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Medication: Cholesterol lowering	6.0	9.4	9.5	-3.1	3.1
Osteoarthritis (self-reported)	5.6	7.3	14.2	0.6	-3.8
Sitting height	4.5	32.1	37.6	6.1	-5.2
High cholesterol (Self-reported)	4.5	8.0	10.5	-3.2	2.4
Number of children fathered	4.4	4.9	9.6	0.5	-3.1
Headache pain in last month	4.3	7.4	8.4	-2.5	2.9
Comparative height size at age 10	4.3	23.7	33.2	3.8	-5.8
Supplements: Calcium	4.2	4.6	8.1	2.9	-1.0
Financial difficulties in last 2 years	4.1	5.6	6.6	2.6	-2.1
Loud music exposure frequency	4.1	4.5	6.7	2.6	-1.5
Medication: Simvastatin	3.9	5.7	6.5	-2.5	2.2
Risk taking	3.9	5.6	8.6	1.6	-2.9
Medication for cholesterol, blood pressure or diabetes	3.5	5.8	6.9	2.6	-2.2
HbA1C	3.4	3.8	6.9	0.8	-2.6
Severe depression (siblings)	3.4	3.8	4.5	1.8	-2.1
Standing height	3.2	32.1	38.3	5.1	-6.2
Medication: Gliclazide	3.1	3.5	5.4	-1.3	2.3
Alcohol drinker status: Previous	3.0	3.4	6.8	-2.6	0.1
Supplements: Fish oil (including cod liver oil)	2.9	3.8	4.2	1.9	-2.0
Height	2.7	52.1	73.6	5.5	-8.6
Mouth/teeth dental problems: Bleeding gums	2.7	3.5	4.8	1.5	-2.2
Smoking Status	2.5	6.0	6.6	2.3	-2.6
Trunk fat mass	2.5	10.6	16.7	2.1	-4.1
Osteoporosis (self-reported)	2.5	3.1	4.1	2.0	-1.5
Fed-up feelings	2.4	4.3	4.5	2.1	-2.0
Miserableness	2.4	4.1	4.5	2.1	-2.0
Supplements: Zinc	2.3	2.5	2.7	1.5	-1.6
Relative age voice broke	2.3	3.6	5.6	-2.4	1.2
Father’s age at death	2.3	3.1	3.6	1.6	-1.9
Pulse wave reflection index	2.3	2.9	4.6	-2.1	1.1
Angina (self-reported)	2.3	3.0	5.0	-2.2	1.0
Gout (self-reported)	2.2	3.1	5.7	2.4	-0.7
Medication: Blood pressure	2.2	3.9	4.8	-2.2	1.7
Mineral and other dietary supplements	2.2	2.9	3.0	-1.7	1.7
Hearing aid user	2.2	2.5	2.6	1.5	-1.6
Unable to work because of sickness or disability	2.2	2.9	3.8	-1.9	1.4
Hearing difficulty/problems: Yes	2.1	3.2	5.4	1.0	-2.3
Maternal smoking around birth	2.1	3.1	4.5	2.1	-1.3
Had other major operations	2.1	2.5	3.4	1.3	-1.9
Qualifications: College or University degree	2.1	6.8	9.8	-3.1	1.9
Mouth/teeth dental problems: Loose teeth	2.1	2.5	4.5	-2.1	0.8
Lung FEV1/FVC ratio	2.0	10.4	11.8	-3.4	3.0
Angina	2.0	2.6	4.1	-2.0	1.0
Weight	2.0	9.7	15.3	2.0	-3.9
Arm fat-free mass (right)	2.0	10.2	15.7	2.2	-4.0
Had major operations	2.0	2.4	4.7	-2.2	-0.1
Supplements: Vitamin C	2.0	2.3	2.4	1.5	-1.5
Breast cancer (self-reported)	1.9	2.2	4.5	0.2	-2.1
Arm fat-free mass (left)	1.9	9.8	16.7	1.7	-4.1
Arm predicted mass (left)	1.9	9.7	16.3	1.8	-4.0
Relative age of first facial hair	1.8	3.7	4.4	-2.1	1.7
Leg fat-free mass (left)	1.8	9.3	13.6	2.3	-3.7
Alcohol usually taken with meals	1.8	3.0	3.8	-1.4	2.0
Trunk fat-free mass	1.8	10.5	15.8	2.2	-4.0
Trunk predicted mass	1.8	10.3	15.6	2.2	-4.0
Arm predicted mass (right)	1.8	9.0	14.4	1.9	-3.8
Whole body fat-free mass	1.8	10.1	15.3	2.2	-3.9
Mood swings	1.8	3.3	4.7	1.4	-2.2
Whole body water mass	1.8	10.0	15.1	2.2	-3.9
Ever smoked	1.8	3.1	4.7	2.2	-1.2
Basal metabolic rate	1.8	9.8	15.0	2.1	-3.9
Prostate Cancer	1.7	2.4	4.3	0.7	-2.1
Leg predicted mass (left)	1.7	9.0	13.1	2.2	-3.6
Forced vital capacity (FVC)	1.7	6.6	12.6	3.5	-0.7
Pain all over the body in last month	1.7	1.9	2.0	1.3	-1.4
Medication: Lansoprazole	1.7	1.9	2.6	-1.6	1.1
Ulcerative Colitis (UC)	1.6	2.9	4.1	-1.3	2.0
Trunk fat percentage	1.6	6.2	10.0	1.5	-3.2
Blood clot in the leg (DVT)	1.6	2.1	3.8	-2.0	0.5
Forced vital capacity (FVC), Best measure	1.6	5.9	11.2	3.3	-0.7
Alcohol intake frequency.	1.6	3.7	5.8	-2.4	1.3
Wears glasses or contact lenses	1.6	1.9	1.9	-1.4	1.3
Crohns Disease (2012)	1.5	2.3	3.8	2.0	-0.9
Whole body fat mass	1.5	6.3	10.8	1.4	-3.3
Knee pain experienced in last month	1.5	2.3	3.2	-1.2	-1.8
Leg fat-free mass (right)	1.5	7.9	11.0	2.2	-3.3
Ever had bowel cancer screening	1.5	1.7	2.6	-0.9	-1.6
Friendships satisfaction	1.5	1.9	3.6	1.9	-0.4
Medication: Aspirin	1.5	1.9	2.0	-1.3	1.4
Leg predicted mass (right)	1.5	7.8	10.6	2.2	-3.2
Schizophrenia vs Biploar Disorder	1.4	1.9	2.0	1.3	-1.4
LDL Cholesterol	1.4	2.2	3.6	-1.9	0.9
Medication: Co-codamol	1.4	1.6	3.2	0.2	-1.8
Medication: Aspirin	1.4	1.9	2.4	-1.1	1.6
Neuroticism (2016)	1.3	1.9	3.3	1.8	-0.7
Cardiovascular Disease	1.3	4.2	7.1	-1.1	2.7
Vitamin and mineral supplements	1.3	1.8	2.1	-1.2	1.4
High blood pressure (mother)	1.3	1.8	2.5	-1.6	1.0
Hearing difficulty/problems with background noise	1.3	2.0	2.2	1.4	-1.5
Fluid intelligence score	1.3	2.6	3.7	-1.2	-1.9
Hip circumference	1.3	5.5	8.4	1.6	-2.9
Handedness (chirality/laterality): Left-handed	1.3	1.6	2.1	1.1	-1.4
Qualifications: nursing, teaching	1.3	2.0	2.8	-1.7	1.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.3	2.7	5.1	-0.6	2.3
Waist circumference	1.2	4.3	8.1	0.7	-2.8
Ever highly irritable/argumentative for 2 days	1.2	1.4	2.4	1.5	-0.7
Smoking status: Previous	1.2	1.8	2.5	1.6	-1.1
Deep venous thrombosis (DVT) (self-reported)	1.2	1.6	2.8	-1.7	0.7
Verbal and Numeric Reasoning (VNR)	1.1	2.6	4.4	-0.9	-2.1
Blood Red Count	1.1	11.0	19.2	-1.7	4.4
Number of treatments/medications taken	1.1	2.1	2.5	-1.6	1.3
Age when periods started (menarche)	1.1	2.7	3.3	-1.8	1.5
Mouth/teeth dental problems	1.1	1.7	2.6	-0.9	1.6
Medication: Ramipril	1.1	1.4	2.3	-0.7	1.5
Falls in the last year	1.1	1.5	2.9	-1.7	-0.1
Depression (self-reported)	1.1	1.3	1.4	1.1	-1.2
Worry too long after embarrassment	1.1	1.9	3.8	-0.1	2.0
Commuting to job workplace: Public transport	1.1	1.4	2.7	-1.6	0.1
Depressed Affect (Nagel 2018)	1.0	2.1	2.4	1.3	-1.5
Current tobacco smoking	1.0	1.6	2.0	1.1	-1.4
Frequency of tiredness / lethargy in last 2 weeks	1.0	1.7	3.4	-0.1	-1.8
Noisy workplace	1.0	1.2	1.5	1.2	1.0
Qualifications: A levels/AS levels or equivalent	1.0	2.2	2.4	-1.4	1.5
Illnesses of mother	1.0	1.3	1.4	1.2	-1.0
Arm fat mass (right)	1.0	4.2	6.8	1.2	-2.6
Hypothyroidism/myxoedema (self-reported)	1.0	2.0	2.5	1.3	-1.6
High blood pressure (siblings)	1.0	1.4	2.4	-1.5	-0.7
Pulse wave peak to peak time	1.0	1.1	1.8	1.4	-0.7
Medication for pain relief, constipation, heartburn	1.0	1.7	2.8	1.7	-0.8
Smoking status: Current	1.0	1.5	2.5	0.8	-1.6
Arm fat mass (left)	1.0	3.9	6.1	1.3	-2.5
Commuting to job workplace: Cycle	1.0	1.2	1.7	1.3	-0.8
Cholesterol lowering medication	1.0	1.5	1.7	-1.3	1.2
Leg fat mass (left)	1.0	3.7	6.7	0.9	-2.6
Neuroticism (Nagel 2018)	0.9	2.2	3.2	1.8	-1.0
Body Mass Index (BMI) (2010)	0.9	1.2	2.3	-1.5	0.4
Medication: Metformin	0.9	1.3	2.6	-0.2	1.6
Past tobacco smoking	0.9	1.7	1.7	-1.3	1.3
Breastfed as a baby	0.9	1.1	1.4	-0.9	1.2
Body fat percentage	0.9	3.5	6.5	0.7	-2.5
Leg fat mass (right)	0.9	3.7	6.8	0.7	-2.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.9	1.1	1.7	-1.3	0.7
Medication for cholesterol	0.9	1.3	1.9	0.9	-1.4
Financial situation satisfaction	0.9	1.1	1.8	1.4	0.7
Medication: Omeprazole (e.g. Zanprol)	0.9	1.1	2.1	-1.5	0.3
Pain experienced in last month	0.9	1.4	1.8	1.1	1.3
Intelligence (Savage-Jansen 2018)	0.8	2.5	3.4	-1.8	-1.3
Schizophrenia (2018)	0.8	1.7	3.3	-0.4	-1.8
Primary Biliary Cirrhosis	0.8	1.2	2.0	-1.4	0.6
Allergy or Eczema	0.8	2.2	3.7	-1.9	0.9
Diabetes (mother)	0.8	1.1	1.4	0.9	-1.2
Diabetes (self-reported)	0.8	1.2	1.4	-1.0	1.2
Serious illness, injury or assault of a close relative in last 2 years	0.8	0.9	1.7	1.3	-0.5
Leg pain on walking	0.8	1.0	2.0	-1.4	0.3
Commuting to job workplace: Walk	0.8	0.9	1.5	-1.2	-0.6
Irritability	0.8	1.3	2.7	0.1	-1.6
Irritable Bowel Disease (IBD)	0.7	1.6	2.9	-0.6	1.7
Heel T-Score	0.7	5.2	10.0	0.6	-3.2
Hand grip strength (left)	0.7	2.0	3.9	0.1	-2.0
Average weekly spirits intake	0.7	0.9	1.0	-1.0	0.9
Time employed in main current job	0.7	0.8	1.6	-1.3	0.3
Happiness	0.7	0.8	1.0	1.0	0.8
Migraine (self-reported)	0.7	0.9	1.1	-1.1	0.8
Medication: Allopurinol	0.7	1.0	1.9	1.4	-0.2
Medication: Omeprazole	0.7	0.8	1.6	-1.3	0.2
Back pain experienced in last month	0.7	1.1	1.9	-0.4	-1.4
Vascular/heart problems diagnosed by doctor	0.7	1.8	3.2	0.6	-1.8
Alzheimer’s Disease (including proxy)	0.6	0.8	1.6	-0.2	1.3
Breast Cancer	0.6	1.5	3.0	-0.2	1.7
Systolic Blood Pressure	0.6	3.2	3.3	1.7	1.8
Neuroticism	0.6	1.4	2.6	1.6	-0.4
Taking other prescription medications	0.6	0.9	1.6	-1.3	-0.3
Heel bone mineral density (BMD) T-score, automated (left)	0.6	1.3	2.6	-0.3	-1.6
Qualifications: CSEs or equivalent	0.6	0.8	1.7	1.3	0.0
Stomach or abdominal pain in last month	0.6	0.8	1.4	0.4	-1.2
Heel bone mineral density (BMD) T-score, automated (right)	0.6	1.4	2.6	0.3	-1.6
Neuroticism score	0.6	1.3	2.3	1.5	-0.4
Forced expiratory volume in 1-second (FEV1)	0.6	2.0	3.9	2.0	0.3
Forced expiratory volume in 1-second (FEV1), Best measure	0.6	2.1	3.8	1.9	0.6
Length of working week for main job	0.6	0.7	1.4	-0.2	-1.2
Seen doctor (GP) for nerves, anxiety, tension or depression	0.6	1.0	1.9	1.4	0.2
Leg fat percentage (right)	0.6	2.3	4.5	-0.4	-2.1
Mean time to correctly identify matches	0.6	1.1	2.1	-1.4	0.3
Overall health rating	0.6	1.2	2.4	1.6	-0.1
Family relationship satisfaction	0.6	0.8	1.5	-0.3	1.2
Illness, injury, bereavement, stress in last 2 years	0.6	0.7	1.5	0.2	1.2
Diabetes diagnosed by doctor	0.6	1.0	1.2	-0.9	1.1
Ever taken oral contraceptive pill	0.6	0.6	1.0	1.0	-0.5
Average weekly beer plus cider intake	0.6	0.9	1.4	1.2	-0.6
Ever depressed for a whole week	0.6	0.7	1.0	-0.6	1.0
Bipolar Disorder or Schizophrenia	0.5	1.2	2.4	-0.2	-1.5
Alzheimer’s Disease (in mother)	0.5	0.5	0.5	-0.7	0.7
Age at First Birth	0.5	0.7	1.0	-1.0	0.6
Bipolar Disorder (2011)	0.5	0.5	1.1	-1.0	0.0
Fasting Glucose	0.5	0.6	0.6	-0.8	-0.8
Schizophrenia (2014)	0.5	1.1	2.0	0.4	-1.4
Hypothyroidism (self reported)	0.5	1.2	2.3	0.3	-1.5
Ever had hysterectomy (womb removed)	0.5	0.6	1.2	-0.0	1.1
Systolic blood pressure, automated reading	0.5	1.4	2.0	0.9	1.4
Townsend deprivation index at recruitment	0.5	0.8	1.0	0.7	-1.0
Average weekly fortified wine intake	0.5	0.6	1.2	-0.1	-1.1
Medication: Atenolol	0.5	0.6	1.2	0.0	1.1
Hair/balding pattern: Pattern 2	0.5	0.6	1.1	-1.0	0.4
Ever unenthusiastic/disinterested for a whole week	0.5	0.6	1.2	-0.3	1.1
Qualifications: None of the above	0.5	1.1	1.6	0.7	-1.3
Lung cancer (father)	0.5	0.6	1.1	0.0	1.1
Pulse wave Arterial Stiffness index	0.5	0.5	1.0	-1.0	0.2
Birth weight of first child	0.5	0.9	1.9	0.1	1.4
Chronic bronchitis/emphysema (mother)	0.5	0.5	0.8	0.9	-0.5
Heart disease (mother)	0.5	0.6	0.6	-0.8	0.8
Pulse rate, automated reading	0.5	1.6	2.3	1.5	-0.9
Hypertension (Self-reported)	0.5	1.4	2.8	-0.2	1.7
Guilty feelings	0.5	0.8	1.6	1.3	-0.2
Medication: Bendroflumethiazide	0.5	0.7	1.3	0.4	1.1
Leg fat percentage (left)	0.5	1.9	3.7	-0.3	-1.9
Age started oral contraceptive pill	0.5	0.6	0.8	0.6	-0.9
Myopia	0.5	0.8	1.6	0.1	1.2
Depression (Nagel 2018)	0.4	0.6	0.8	-0.9	0.6
Alzheimer’s Disease (in father)	0.4	0.5	0.5	0.7	0.7
HDL Cholesterol	0.4	0.7	0.7	0.9	-0.8
Respiratory disease	0.4	1.0	1.8	0.3	-1.4
Frequency of depressed mood in last 2 weeks	0.4	0.6	1.1	-0.3	1.1
Diabetes (father)	0.4	0.5	1.0	-1.0	-0.2
Hand grip strength (right)	0.4	1.0	2.0	0.1	-1.4
High blood pressure	0.4	1.1	2.1	-0.3	1.4
Supplements: Glucosamine	0.4	0.5	0.7	0.5	-0.8
Hayfever/allergic rhinitis (self-reported)	0.4	0.6	1.1	-0.0	1.1
Illnesses of siblings	0.4	0.5	0.8	0.9	0.6
Arm fat percentage (right)	0.4	1.5	2.7	0.6	-1.6
Worrier / anxious feelings	0.4	0.7	1.4	1.2	0.2
Tense / ‘highly strung’	0.4	0.7	0.9	0.9	-0.7
Emphysema/chronic bronchitis	0.4	0.5	0.8	-0.9	0.4
Suffer from ‘nerves’	0.4	0.6	1.2	0.3	1.1
Qualifications: NVQ or HND or HNC or equivalent	0.4	0.5	0.9	0.1	-1.0
Ever had stillbirth, spontaneous miscarriage or termination	0.4	0.4	0.5	-0.7	0.5
Tinnitus: Yes, now most or all of the time	0.4	0.5	1.0	1.0	-0.0
Medication: Blood pressure	0.4	0.7	1.3	0.4	1.2
Medication: Atorvastatin	0.4	0.5	1.0	-1.0	-0.2
Alcohol drinker status: Never	0.4	0.5	0.7	0.8	-0.6
Worry (Nagel 2018)	0.3	0.6	1.2	1.1	0.1
Ovarian Cancer	0.3	0.3	0.6	0.8	0.3
Coronary Artery Disease (CAD)	0.3	0.3	0.4	-0.6	-0.6
Mean Putamen Volume	0.3	0.3	0.7	-0.0	-0.8
Triglycerides	0.3	0.4	0.8	0.2	-0.9
Ulcerative Colitis	0.3	0.4	0.8	-0.2	0.9
Blood Eosinophil Count	0.3	2.3	4.5	0.3	-2.1
Blood White Count	0.3	2.5	3.6	-1.2	1.9
BMI	0.3	1.6	2.6	0.8	-1.6
Type 2 Diabetes (T2D) (2018)	0.3	0.5	0.7	0.6	-0.8
Medication for hormone replacement therapy	0.3	0.3	0.6	0.1	-0.8
Pack years adult smoking proportion	0.3	0.4	0.6	0.5	-0.8
Medication: Levothyroxine sodium	0.3	0.5	0.9	0.4	-0.9
Number of incorrect matches in round	0.3	0.5	0.7	-0.5	-0.8
Hair/balding pattern: Pattern 3	0.3	0.4	0.6	0.8	-0.4
Mouth/teeth dental problems: Dentures	0.3	0.5	0.9	0.2	-1.0
Prospective memory result	0.3	0.4	0.4	-0.7	-0.6
Impedance of arm (left)	0.3	1.4	2.8	1.7	-0.1
Medication: Amlodipine	0.3	0.4	0.8	-0.0	0.9
Medication: Ventolin 100micrograms inhaler	0.3	0.4	0.7	-0.9	-0.3
Exposure to tobacco smoke outside home	0.3	0.5	0.9	-0.9	0.2
Comparative body size at age 10	0.3	0.8	0.8	-0.9	0.9
Number of full brothers	0.3	0.4	0.8	-0.9	-0.0
Seen a psychiatrist for nerves, anxiety, tension or depression	0.3	0.4	0.5	0.7	0.5
Reason for reducing amount of alcohol drunk: Health precaution	0.3	0.4	0.6	-0.8	-0.4
Health satisfaction	0.3	0.4	0.8	-0.1	0.9
Shortness of breath walking on level ground	0.3	0.4	0.5	-0.7	-0.5
Number of full sisters	0.3	0.4	0.6	0.4	-0.8
Illnesses of father: Heart disease	0.3	0.4	0.4	0.7	-0.6
Forced expiratory volume in 1-second (FEV1), predicted	0.3	0.6	1.1	1.0	-0.3
Arm fat percentage (left)	0.3	1.4	2.3	0.6	-1.5
Eye problems/disorders: Cataract	0.3	0.4	0.8	-0.1	-0.9
Eye problems/disorders: Glaucoma	0.3	0.3	0.7	0.8	-0.1
Medication: Paracetamol	0.3	0.5	0.9	-0.9	0.4
Fractured/broken bones in last 5 years	0.3	0.3	0.6	0.2	0.8
Pack years of smoking	0.3	0.4	0.6	0.3	-0.8
Lupus	0.2	0.4	0.6	0.4	-0.8
Type 2 Diabetes (T2D) (2012)	0.2	0.3	0.5	0.7	0.2
Blood Platelet Count	0.2	1.8	2.5	-1.6	1.0
Waist Hip Ratio (WHR)	0.2	1.1	2.1	0.0	-1.4
Lung FVC	0.2	0.8	0.9	0.8	0.9
Chronotype (morning person)	0.2	0.4	0.7	0.8	-0.4
Sensitivity / hurt feelings	0.2	0.3	0.4	0.7	-0.4
Eye problems/disorders: Diabetes related eye disease	0.2	0.2	0.3	-0.3	0.6
Body mass index (BMI)	0.2	0.9	1.7	-0.0	-1.3
Had menopause	0.2	0.3	0.5	0.7	-0.2
Heart attack	0.2	0.2	0.4	0.0	0.6
Impedance of arm (right)	0.2	0.8	1.5	1.2	-0.2
Pulse rate	0.2	0.3	0.5	0.3	-0.7
Exposure to tobacco smoke at home	0.2	0.2	0.4	0.3	-0.6
Eye problems/disorders: None of the above	0.2	0.2	0.4	-0.6	0.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.2	0.2	0.3	0.5	0.4
Age at last live birth	0.2	0.3	0.6	0.0	0.8
Commuting to job workplace: Car/motor vehicle	0.2	0.2	0.4	-0.2	0.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.2	0.2	0.3	-0.4	-0.5
Mother’s age at death	0.2	0.3	0.4	-0.7	0.4
Pain type(s) experienced in last month: Hip pain	0.2	0.3	0.4	-0.6	-0.4
Medication: Lisinopril	0.2	0.3	0.5	-0.2	0.7
Illnesses of father: High blood pressure	0.2	0.2	0.4	-0.6	-0.1
Number of operations (self-reported)	0.2	0.3	0.6	-0.2	-0.8
Ever had prostate specific antigen (PSA) test	0.2	0.2	0.3	-0.4	0.5
Diastolic blood pressure, automated reading	0.2	0.7	1.4	0.1	1.2
Basal cell carcinoma (self-reported)	0.2	0.2	0.3	-0.3	-0.6
Heart attack/myocardial infarction (self-reported)	0.2	0.2	0.3	0.5	0.4
Impedance of whole body	0.2	0.9	1.8	1.3	-0.3
Crohns Disease (2017)	0.1	0.3	0.4	0.4	0.7
Major Depression (MDD)	0.1	0.2	0.3	0.5	0.3
Reaction Time	0.1	0.3	0.3	-0.6	0.4
Other serious medical condition/disability diagnosed by doctor	0.1	0.1	0.3	0.0	0.5
Bilateral oophorectomy (both ovaries removed)	0.1	0.1	0.1	-0.3	0.1
Tinnitus: Yes, but not now, but have in the past	0.1	0.2	0.3	-0.2	0.5
Multivitamins +/- minerals	0.1	0.1	0.2	-0.2	-0.4
Diverticular disease/diverticulitis (self-reported)	0.1	0.1	0.1	0.3	-0.2
Chronic bronchitis/emphysema (father)	0.1	0.1	0.1	0.3	-0.3
Nervous feelings	0.1	0.2	0.2	0.4	0.5
Frequency of tenseness / restlessness in last 2 weeks	0.1	0.1	0.2	-0.5	-0.0
Alcohol intake versus 10 years previously	0.1	0.1	0.3	0.5	0.1
Number of live births	0.1	0.2	0.3	0.5	-0.2
Medication: Ibuprofen (e.g. Nurofen)	0.1	0.2	0.2	-0.4	0.4
Peak expiratory flow (PEF)	0.1	0.2	0.3	0.5	-0.1
Qualifications: O levels/GCSEs or equivalent	0.1	0.2	0.4	0.7	0.2
Glaucoma (self-reported)	0.1	0.1	0.1	0.3	0.3
Age at first live birth	0.1	0.2	0.2	-0.5	-0.5
Neck or shoulder pain in last month	0.1	0.2	0.3	-0.5	-0.2
Medication: Ibuprofen	0.1	0.2	0.2	-0.3	0.5
Medication: Seretide 50 evohaler	0.1	0.1	0.2	0.4	-0.1
Chest pain or discomfort	0.1	0.1	0.2	0.3	0.4
Illnesses of siblings: Diabetes	0.1	0.1	0.3	-0.1	-0.5
Average weekly red wine intake	0.1	0.1	0.2	-0.5	-0.2
Mouth/teeth dental problems: Mouth ulcers	0.1	0.1	0.2	0.4	0.3
Illnesses of father: None of the above (group 1)	0.1	0.1	0.2	0.2	0.4
Average weekly champagne plus white wine intake	0.1	0.1	0.1	0.4	0.2
Bipolar Disorder (2018)	0.0	0.0	0.1	0.2	-0.2
Rheumatoid Arthritis	0.0	0.0	0.1	-0.0	-0.3
Hair Pigment	0.0	0.6	1.2	1.1	0.1
Tanning	0.0	0.1	0.3	0.5	0.1
Ever used hormone-replacement therapy (HRT)	0.0	0.0	0.0	-0.0	-0.1
Impedance of leg (right)	0.0	0.2	0.2	0.5	-0.4
Frequency of unenthusiasm / disinterest in last 2 weeks	0.0	0.0	0.1	0.1	0.3
Serious illness, injury or assault to yourself	0.0	0.0	0.1	-0.2	-0.1
Hayfever, allergic rhinitis or eczema	0.0	0.1	0.1	-0.2	0.4
Impedance of leg (left)	0.0	0.1	0.2	0.4	-0.0
Allergy	0.0	0.0	0.1	0.1	-0.3
Asthma	0.0	0.0	0.0	0.1	-0.1
Hair/balding pattern: Pattern 4	0.0	0.0	0.0	-0.2	0.2
Medication: Paracetamol	0.0	0.0	0.0	-0.2	-0.1
Birth weight	0.0	0.0	0.1	-0.2	-0.2
Wheeze or whistling in the chest in last year	0.0	0.0	0.0	0.2	-0.2
Loneliness, isolation	0.0	0.0	0.0	0.1	-0.2
Long-standing illness, disability or infirmity	0.0	0.1	0.1	0.3	0.1
Asthma (self-reported)	0.0	0.1	0.1	0.2	-0.3
Number of self-reported non-cancer illnesses	0.0	0.1	0.1	-0.0	0.3
Heart disease (siblings)	0.0	0.0	0.0	-0.0	-0.2

Hub : Genes

OTUD1

Models

Trait associations