TWAS hub - ENKUR

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	ROSMAP	Brain Pre-frontal Cortex	0.0459	0.0191	0.0027	0.032	0.016	-0.001	0.013	0.009	5.5e-05	0.0034	0.48	0.0069	0.024
2	TCGA	Testicular Germ Cell Tumors	0.3020	0.1050	0.0021	-0.004	0.010	0.000	NA	-0.008	4.7e-01	0.1300	0.33	NA	0.790

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Time employed in main current job	4.5	5.2	9.6	3.1	0.9
Noisy workplace	4.4	5.4	10.2	3.2	0.8
Average weekly fortified wine intake	4.3	5.1	9.3	-3.1	-0.9
Mean Putamen Volume	3.9	4.4	8.8	-3.0	0.3
Eye problems/disorders: None of the above	3.8	4.4	6.6	2.6	-1.4
Ever taken oral contraceptive pill	3.3	3.7	6.5	2.5	-0.9
Frequency of tiredness / lethargy in last 2 weeks	3.2	5.2	7.7	-1.7	2.8
Qualifications: NVQ or HND or HNC or equivalent	3.1	3.7	6.9	2.6	0.7
Ever had hysterectomy (womb removed)	3.0	3.4	5.6	-2.4	1.1
Wears glasses or contact lenses	2.6	3.0	3.2	-1.8	1.7
Lung cancer (father)	2.4	2.8	4.9	0.9	2.2
Medication: Ibuprofen	2.4	2.9	5.3	-0.6	2.3
Average weekly beer plus cider intake	2.4	3.5	5.2	2.3	-1.3
Medication: Ibuprofen (e.g. Nurofen)	2.3	2.9	5.1	0.8	2.2
Osteoarthritis (self-reported)	2.3	3.0	5.7	-2.4	0.5
Commuting to job workplace: Public transport	2.3	2.8	4.8	-0.9	2.2
Exposure to tobacco smoke at home	2.2	2.5	3.1	-1.4	1.8
Supplements: Zinc	2.1	2.3	4.1	-0.7	2.0
Schizophrenia vs Biploar Disorder	2.0	2.7	4.3	-2.1	1.0
Respiratory disease	2.0	4.3	8.0	0.8	-2.8
Diabetes (mother)	2.0	2.6	4.6	2.1	-0.8
Ever had prostate specific antigen (PSA) test	2.0	2.3	3.7	-0.9	-1.9
Height	1.9	37.3	69.4	-8.3	-2.3
Standing height	1.9	18.7	36.0	-6.0	-1.2
Mood swings	1.9	3.5	6.6	-0.6	2.6
Commuting to job workplace: Cycle	1.9	2.2	4.3	2.1	-0.4
Depression (Nagel 2018)	1.8	2.7	3.7	-1.3	1.9
Townsend deprivation index at recruitment	1.8	2.5	4.4	2.1	0.8
Medication: Ventolin 100micrograms inhaler	1.8	2.3	4.3	0.4	-2.1
Current tobacco smoking	1.7	2.7	3.8	1.9	1.3
Qualifications: nursing, teaching	1.7	2.7	4.6	-2.1	0.9
High cholesterol (Self-reported)	1.7	3.0	5.8	-0.5	2.4
Diabetes (father)	1.6	2.0	3.5	1.9	0.7
Hair/balding pattern: Pattern 3	1.6	2.4	4.8	-2.2	0.2
Smoking status: Current	1.6	2.6	4.4	2.1	0.9
Eye problems/disorders: Cataract	1.5	1.7	2.6	-1.6	0.9
Deep venous thrombosis (DVT) (self-reported)	1.5	1.9	3.7	-0.3	-1.9
Supplements: Glucosamine	1.4	1.9	3.7	-1.9	0.1
Asthma	1.4	2.8	4.5	1.1	-2.1
Average weekly red wine intake	1.4	2.1	2.3	-1.5	-1.4
Mouth/teeth dental problems: Mouth ulcers	1.4	2.2	2.5	-1.6	1.4
Breast cancer (self-reported)	1.4	1.7	3.3	-0.2	1.8
Guilty feelings	1.4	2.1	4.0	2.0	0.4
Myopia	1.4	2.0	3.9	-2.0	0.3
Heart disease (siblings)	1.4	1.7	3.0	-0.6	-1.7
Blood White Count	1.3	9.6	19.0	-4.4	0.4
Frequency of depressed mood in last 2 weeks	1.3	1.9	2.0	-1.4	1.4
Severe depression (siblings)	1.3	1.4	2.5	-1.6	0.5
Stomach or abdominal pain in last month	1.3	1.6	1.9	1.1	-1.4
Had other major operations	1.3	1.6	1.8	-1.3	-1.2
Medication: Amlodipine	1.3	1.8	2.5	1.0	1.6
Birth weight	1.3	2.8	4.1	-1.2	-2.0
Health satisfaction	1.3	1.6	3.2	-1.8	0.3
Knee pain experienced in last month	1.3	2.0	2.0	-1.4	1.4
Forced expiratory volume in 1-second (FEV1), predicted	1.3	2.7	4.9	-2.2	-0.7
Risk taking	1.3	1.8	3.3	1.8	-0.6
Ever depressed for a whole week	1.3	1.6	2.0	1.1	-1.4
Alzheimer’s Disease (in mother)	1.2	1.4	2.2	1.5	0.8
Neuroticism (2016)	1.2	1.7	2.9	1.7	0.7
Triglycerides	1.2	2.0	4.0	-0.1	2.0
Medication: Atenolol	1.2	1.5	3.0	1.7	0.1
Pulse wave reflection index	1.2	1.5	2.8	-0.4	-1.7
Mouth/teeth dental problems: Bleeding gums	1.2	1.6	2.7	-1.6	0.7
Age at first live birth	1.2	2.2	2.8	-1.7	1.2
Medication: Seretide 50 evohaler	1.2	1.4	2.4	-1.5	-0.7
Illnesses of father: Heart disease	1.2	1.7	2.5	0.9	-1.6
Friendships satisfaction	1.2	1.4	2.4	1.6	0.7
Asthma (self-reported)	1.2	2.4	4.0	0.9	-2.0
Depressed Affect (Nagel 2018)	1.1	2.4	3.7	1.0	1.9
Body Mass Index (BMI) (2010)	1.1	1.5	2.5	-0.7	1.6
Hearing difficulty/problems: Yes	1.1	1.7	3.4	0.1	1.8
Frequency of unenthusiasm / disinterest in last 2 weeks	1.1	1.4	2.8	0.3	1.7
Diverticular disease/diverticulitis (self-reported)	1.1	1.3	2.0	0.7	-1.4
Number of incorrect matches in round	1.1	1.8	2.0	1.3	1.4
Happiness	1.1	1.3	2.6	-0.1	1.6
Number of children fathered	1.1	1.2	2.1	1.5	0.6
Medication: Omeprazole	1.1	1.3	2.6	1.6	-0.2
Neuroticism (Nagel 2018)	1.0	2.5	2.5	1.6	1.6
Cardiovascular Disease	1.0	3.3	4.4	-1.5	2.1
High blood pressure (mother)	1.0	1.3	2.6	-0.3	1.6
Medication: Simvastatin	1.0	1.5	2.9	-0.4	1.7
Medication: Cholesterol lowering	1.0	1.5	2.7	0.6	1.6
Length of working week for main job	1.0	1.1	1.5	1.2	0.9
Pulse wave peak to peak time	1.0	1.2	1.8	-1.3	-0.7
Had major operations	1.0	1.2	1.4	1.2	-1.0
LDL Cholesterol	0.9	1.4	2.1	-0.9	1.4
Sensitivity / hurt feelings	0.9	1.5	2.3	0.9	1.5
Eye problems/disorders: Diabetes related eye disease	0.9	1.0	1.2	1.1	0.9
Mouth/teeth dental problems	0.9	1.4	2.6	1.6	-0.5
Medication: Ramipril	0.9	1.1	1.9	-1.4	0.5
Blood clot in the leg (DVT)	0.9	1.2	2.4	-0.1	-1.5
Seen a psychiatrist for nerves, anxiety, tension or depression	0.9	1.2	2.2	0.4	1.5
Emphysema/chronic bronchitis	0.9	1.0	2.0	-1.4	0.1
Neck or shoulder pain in last month	0.9	1.2	1.5	-1.0	1.2
Suffer from ‘nerves’	0.9	1.4	2.5	0.5	1.6
Chest pain or discomfort	0.9	1.3	2.3	-1.5	-0.6
Miserableness	0.9	1.6	2.4	1.5	0.9
Medication: Lisinopril	0.9	1.2	1.7	-1.3	-0.8
Cholesterol lowering medication	0.9	1.4	2.4	-0.7	1.5
Bipolar Disorder (2018)	0.8	1.3	2.2	-0.6	-1.5
Bipolar Disorder (2011)	0.8	0.8	1.3	0.5	-1.2
Primary Biliary Cirrhosis	0.8	1.1	1.2	-1.0	-1.1
Lung FVC	0.8	4.2	5.1	1.8	2.3
Chronotype (morning person)	0.8	1.8	2.3	1.1	-1.5
Sitting height	0.8	5.5	10.6	-3.3	-0.6
Alcohol usually taken with meals	0.8	1.4	2.3	-0.7	-1.5
Fluid intelligence score	0.8	1.7	3.4	-0.0	-1.8
Tense / ‘highly strung’	0.8	1.4	2.6	1.6	-0.4
Exposure to tobacco smoke outside home	0.8	1.1	1.3	-0.9	1.1
Medication: Allopurinol	0.8	1.0	1.2	-0.9	1.1
Comparative height size at age 10	0.8	4.2	7.0	-2.6	-1.2
Smoking status: Previous	0.8	1.2	2.0	-0.7	-1.4
Financial situation satisfaction	0.8	1.0	2.0	0.0	-1.4
Fractured/broken bones in last 5 years	0.8	1.1	1.7	-0.7	-1.3
Supplements: Calcium	0.8	0.9	1.6	-0.4	1.3
Reaction Time	0.7	1.4	1.5	-1.2	-1.1
Fasting Glucose	0.7	0.8	1.6	-1.3	-0.0
Vitamin and mineral supplements	0.7	0.9	1.6	0.4	-1.3
Pack years adult smoking proportion	0.7	1.1	2.1	1.4	-0.2
Multivitamins +/- minerals	0.7	0.9	1.8	-0.3	1.4
Hair/balding pattern: Pattern 2	0.7	0.9	0.9	1.0	-0.9
Hayfever/allergic rhinitis (self-reported)	0.7	0.9	1.2	-1.1	0.8
Trunk fat-free mass	0.7	3.9	7.1	-2.7	-0.8
Illnesses of mother	0.7	0.9	1.8	-0.2	-1.3
Ever highly irritable/argumentative for 2 days	0.7	0.9	1.0	1.0	-0.9
Mean time to correctly identify matches	0.7	1.3	2.3	-1.5	-0.5
Age at last live birth	0.7	1.0	1.9	-1.4	-0.2
Illnesses of siblings: Diabetes	0.7	0.9	1.0	1.0	0.9
Loneliness, isolation	0.7	1.0	2.0	0.3	1.4
Ever had bowel cancer screening	0.7	0.9	1.7	-1.3	0.0
Pain experienced in last month	0.7	1.2	2.2	1.5	-0.4
Ovarian Cancer	0.6	0.7	0.9	0.9	-0.8
Leg fat-free mass (left)	0.6	3.0	4.4	-2.1	-1.3
Taking other prescription medications	0.6	0.9	1.6	1.3	-0.4
Frequency of tenseness / restlessness in last 2 weeks	0.6	1.0	2.0	-0.2	1.4
Pain all over the body in last month	0.6	0.7	0.9	0.7	1.0
Alcohol intake versus 10 years previously	0.6	0.8	1.6	1.3	-0.2
Medication: Lansoprazole	0.6	0.7	1.4	0.1	-1.2
Trunk predicted mass	0.6	3.6	6.5	-2.5	-0.8
Medication for cholesterol, blood pressure or diabetes	0.6	1.0	2.0	-0.2	-1.4
High blood pressure (siblings)	0.6	0.9	1.6	-1.3	0.5
Illness, injury, bereavement, stress in last 2 years	0.6	0.7	1.4	-0.0	-1.2
Whole body fat-free mass	0.6	3.6	6.2	-2.5	-1.0
Leg fat-free mass (right)	0.6	3.2	4.0	-2.0	-1.6
Back pain experienced in last month	0.6	0.9	1.8	-0.3	1.3
Illnesses of father: None of the above (group 1)	0.6	0.7	1.1	-1.0	0.7
Whole body water mass	0.6	3.6	6.5	-2.5	-0.9
Leg predicted mass (right)	0.6	3.3	4.2	-2.1	-1.5
Irritability	0.6	1.0	1.1	1.0	1.0
Worry (Nagel 2018)	0.5	1.0	1.9	1.4	0.4
Alzheimer’s Disease (including proxy)	0.5	0.8	1.4	1.2	0.4
Waist Hip Ratio (WHR)	0.5	2.3	4.0	2.0	0.8
Bilateral oophorectomy (both ovaries removed)	0.5	0.6	0.6	-0.7	0.8
Leg predicted mass (left)	0.5	2.9	4.3	-2.1	-1.2
Ever unenthusiastic/disinterested for a whole week	0.5	0.6	1.1	1.0	0.4
Impedance of arm (right)	0.5	2.6	5.1	-2.3	0.1
Number of live births	0.5	0.8	1.4	0.4	-1.2
Qualifications: A levels/AS levels or equivalent	0.5	1.1	1.3	-1.1	-0.9
Qualifications: O levels/GCSEs or equivalent	0.5	0.9	1.1	-1.1	-0.8
Gout (self-reported)	0.5	0.7	0.9	0.7	1.0
Forced vital capacity (FVC), Best measure	0.5	1.7	3.2	-1.8	-0.5
Leg fat percentage (right)	0.5	1.6	1.7	1.2	1.3
Comparative body size at age 10	0.5	1.3	2.5	0.2	-1.6
Medication for pain relief, constipation, heartburn	0.5	0.8	1.6	-0.2	-1.3
Medication: Blood pressure	0.5	0.9	1.6	-0.4	1.3
Number of full sisters	0.5	0.6	1.2	1.1	-0.1
Supplements: Vitamin C	0.5	0.6	1.0	-0.5	1.0
Hypertension (Self-reported)	0.5	1.4	1.5	-1.1	1.2
Number of self-reported non-cancer illnesses	0.5	0.8	1.5	-1.2	0.3
Pain type(s) experienced in last month: Hip pain	0.5	0.7	1.1	0.5	1.1
Alcohol drinker status: Never	0.5	0.6	0.9	-0.6	0.9
Basal metabolic rate	0.5	2.8	4.4	-2.1	-1.0
Leg fat percentage (left)	0.5	1.8	2.1	1.4	1.2
Pack years of smoking	0.5	0.7	1.4	1.2	-0.2
Schizophrenia (2018)	0.4	0.8	1.0	-1.0	0.8
Coronary Artery Disease (CAD)	0.4	0.4	0.6	0.6	-0.8
Crohns Disease (2012)	0.4	0.6	1.0	1.0	0.4
Lung FEV1/FVC ratio	0.4	1.9	3.6	1.9	0.4
Angina	0.4	0.5	0.6	0.6	-0.8
Hand grip strength (right)	0.4	1.0	1.4	-1.2	-0.7
Forced vital capacity (FVC)	0.4	1.5	1.8	-1.1	1.3
Neuroticism score	0.4	0.9	1.3	0.8	1.1
Father’s age at death	0.4	0.6	1.0	-0.3	-1.0
Mouth/teeth dental problems: Dentures	0.4	0.6	0.6	-0.8	0.8
Forced expiratory volume in 1-second (FEV1), Best measure	0.4	1.3	2.3	-1.5	-0.5
Pulse wave Arterial Stiffness index	0.4	0.5	0.9	0.9	0.3
Impedance of arm (left)	0.4	1.8	3.5	-1.9	-0.2
Seen doctor (GP) for nerves, anxiety, tension or depression	0.4	0.6	0.7	0.9	0.8
Birth weight of first child	0.4	0.7	1.3	-1.2	0.2
Arm fat-free mass (right)	0.4	1.9	3.4	-1.9	-0.6
Reason for reducing amount of alcohol drunk: Health precaution	0.4	0.4	0.8	0.4	-0.9
Heart disease (mother)	0.4	0.5	0.9	0.3	0.9
Arm predicted mass (right)	0.4	2.1	4.1	-2.0	-0.3
Alcohol intake frequency.	0.4	1.0	1.6	-1.2	0.6
Tinnitus: Yes, now most or all of the time	0.4	0.4	0.9	0.1	-0.9
Medication: Bendroflumethiazide	0.4	0.6	1.2	1.1	0.1
Arm fat-free mass (left)	0.4	1.9	3.5	-1.9	-0.6
Number of operations (self-reported)	0.4	0.6	1.2	-1.1	-0.3
Alcohol drinker status: Previous	0.4	0.4	0.8	-0.9	-0.3
Arm predicted mass (left)	0.4	1.9	3.6	-1.9	-0.5
Bipolar Disorder or Schizophrenia	0.3	0.7	1.3	-1.2	-0.3
Intelligence (Savage-Jansen 2018)	0.3	0.9	1.6	-0.4	1.3
Breast Cancer	0.3	0.7	1.3	0.2	1.1
Age at First Birth	0.3	0.4	0.4	-0.7	-0.6
Smoking Status	0.3	0.8	1.5	1.2	-0.0
Number of treatments/medications taken	0.3	0.6	0.9	0.6	1.0
Average weekly spirits intake	0.3	0.4	0.7	-0.9	-0.2
Systolic blood pressure, automated reading	0.3	0.9	1.7	0.3	1.3
Medication: Metformin	0.3	0.5	0.9	-0.2	0.9
Impedance of leg (right)	0.3	1.4	2.8	-0.3	1.7
Maternal smoking around birth	0.3	0.4	0.4	0.7	0.6
Fed-up feelings	0.3	0.6	1.0	0.5	1.0
Relative age voice broke	0.3	0.4	0.7	0.9	0.2
Serious illness, injury or assault to yourself	0.3	0.4	0.6	-0.8	0.4
High blood pressure	0.3	0.9	1.2	-0.8	1.1
Body mass index (BMI)	0.3	1.1	2.0	1.4	-0.5
Had menopause	0.3	0.4	0.6	-0.8	0.3
Weight	0.3	1.4	1.8	-1.3	-1.0
Hip circumference	0.3	1.4	2.0	-0.8	-1.4
Pulse rate	0.3	0.6	0.8	0.9	0.5
Prospective memory result	0.3	0.4	0.6	-0.8	0.4
Loud music exposure frequency	0.3	0.4	0.4	-0.6	-0.6
Worry too long after embarrassment	0.3	0.5	0.6	0.8	-0.6
Qualifications: College or University degree	0.3	0.9	1.5	-0.6	-1.2
Angina (self-reported)	0.3	0.5	0.6	0.5	-0.8
Migraine (self-reported)	0.3	0.3	0.5	-0.4	0.7
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.3	0.4	0.7	-0.9	-0.2
Overall health rating	0.3	0.7	1.2	-1.1	-0.3
Handedness (chirality/laterality): Left-handed	0.3	0.3	0.4	-0.6	0.6
Ever had stillbirth, spontaneous miscarriage or termination	0.3	0.3	0.4	-0.4	-0.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.3	0.6	0.6	0.7	-0.8
Eye problems/disorders: Glaucoma	0.3	0.3	0.5	-0.4	-0.7
Supplements: Fish oil (including cod liver oil)	0.3	0.4	0.6	-0.4	-0.7
Unable to work because of sickness or disability	0.3	0.4	0.9	-0.9	-0.1
Medication: Omeprazole (e.g. Zanprol)	0.3	0.3	0.4	0.6	0.5
Alzheimer’s Disease (in father)	0.2	0.2	0.2	-0.4	0.5
Major Depression (MDD)	0.2	0.2	0.4	-0.6	-0.0
Prostate Cancer	0.2	0.2	0.5	0.7	-0.2
Lupus	0.2	0.3	0.5	-0.7	0.5
Schizophrenia (2014)	0.2	0.5	0.5	-0.7	0.6
Ulcerative Colitis	0.2	0.2	0.4	0.6	0.3
Allergy or Eczema	0.2	0.4	0.8	-0.9	-0.3
Type 2 Diabetes (T2D) (2018)	0.2	0.4	0.7	0.9	0.2
Hand grip strength (left)	0.2	0.6	1.1	0.2	-1.1
Medication for hormone replacement therapy	0.2	0.2	0.3	0.4	0.6
Tinnitus: Yes, but not now, but have in the past	0.2	0.2	0.4	0.6	0.0
Medication: Levothyroxine sodium	0.2	0.4	0.7	-0.3	0.8
Chronic bronchitis/emphysema (father)	0.2	0.2	0.2	-0.4	0.5
Impedance of leg (left)	0.2	1.0	1.9	0.3	1.4
Past tobacco smoking	0.2	0.3	0.4	0.4	0.7
Nervous feelings	0.2	0.3	0.7	0.1	0.8
Heart attack	0.2	0.2	0.3	-0.4	-0.5
Allergy	0.2	0.4	0.9	-0.1	0.9
Worrier / anxious feelings	0.2	0.3	0.4	0.7	-0.4
Forced expiratory volume in 1-second (FEV1)	0.2	0.7	0.9	-0.7	0.9
Depression (self-reported)	0.2	0.3	0.5	0.3	0.7
Peak expiratory flow (PEF)	0.2	0.4	0.7	-0.8	0.1
Mouth/teeth dental problems: Loose teeth	0.2	0.3	0.5	-0.3	0.7
Pulse rate, automated reading	0.2	0.6	1.1	1.0	-0.2
Family relationship satisfaction	0.2	0.2	0.3	-0.5	0.4
Commuting to job workplace: Car/motor vehicle	0.2	0.2	0.4	0.6	-0.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.2	0.3	0.4	0.7	0.3
Arm fat percentage (left)	0.2	0.8	1.3	1.1	-0.5
Long-standing illness, disability or infirmity	0.2	0.3	0.5	-0.7	0.3
Medication for cholesterol	0.2	0.3	0.6	-0.2	-0.8
Mother’s age at death	0.2	0.3	0.5	-0.2	-0.7
Medication: Paracetamol	0.2	0.3	0.4	-0.6	0.4
Illnesses of father: High blood pressure	0.2	0.3	0.5	0.7	0.1
Vascular/heart problems diagnosed by doctor	0.2	0.5	0.5	0.7	-0.7
Impedance of whole body	0.2	0.8	1.2	-1.1	0.6
HbA1C	0.1	0.1	0.3	-0.5	0.0
HDL Cholesterol	0.1	0.1	0.2	0.1	0.4
Rheumatoid Arthritis	0.1	0.2	0.4	-0.0	0.6
Blood Eosinophil Count	0.1	0.8	1.1	-1.1	0.7
Blood Platelet Count	0.1	1.7	3.1	-1.8	0.5
Blood Red Count	0.1	1.1	1.3	1.0	-1.1
Heel T-Score	0.1	0.7	1.4	0.0	-1.2
BMI	0.1	0.4	0.7	0.8	0.3
Hypothyroidism (self reported)	0.1	0.3	0.6	-0.2	0.8
Neuroticism	0.1	0.3	0.4	0.6	0.5
Tanning	0.1	0.7	1.3	0.4	-1.1
Other serious medical condition/disability diagnosed by doctor	0.1	0.2	0.2	-0.5	-0.3
Ever used hormone-replacement therapy (HRT)	0.1	0.2	0.2	-0.4	0.4
Trunk fat mass	0.1	0.3	0.4	-0.4	-0.6
Waist circumference	0.1	0.3	0.4	0.5	-0.6
Qualifications: None of the above	0.1	0.3	0.5	0.7	-0.0
Diabetes (self-reported)	0.1	0.2	0.4	0.6	0.1
Illnesses of siblings	0.1	0.1	0.3	-0.5	-0.1
Arm fat percentage (right)	0.1	0.6	0.9	1.0	-0.4
Serious illness, injury or assault of a close relative in last 2 years	0.1	0.1	0.2	0.4	-0.1
Arm fat mass (right)	0.1	0.3	0.4	0.4	-0.7
Hair/balding pattern: Pattern 4	0.1	0.3	0.5	0.3	0.7
Medication: Paracetamol	0.1	0.1	0.2	0.2	-0.4
Headache pain in last month	0.1	0.2	0.5	-0.7	0.1
Hypothyroidism/myxoedema (self-reported)	0.1	0.1	0.2	-0.2	0.5
Chronic bronchitis/emphysema (mother)	0.1	0.1	0.2	-0.0	0.5
Body fat percentage	0.1	0.2	0.5	0.7	-0.0
Wheeze or whistling in the chest in last year	0.1	0.1	0.1	-0.3	0.3
Leg fat mass (right)	0.1	0.2	0.3	0.5	0.4
Medication: Aspirin	0.1	0.1	0.2	-0.3	0.4
Diabetes diagnosed by doctor	0.1	0.1	0.2	0.4	0.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.1	0.1	0.2	-0.4	-0.0
Mineral and other dietary supplements	0.1	0.2	0.3	0.5	0.3
Medication: Aspirin	0.1	0.1	0.1	-0.1	0.4
Medication: Gliclazide	0.1	0.1	0.1	-0.4	0.3
Arm fat mass (left)	0.1	0.3	0.3	0.5	-0.5
Average weekly champagne plus white wine intake	0.1	0.1	0.2	-0.1	0.5
Hearing aid user	0.1	0.1	0.3	0.0	-0.5
Medication: Blood pressure	0.1	0.2	0.4	-0.6	-0.3
Ever smoked	0.1	0.1	0.2	-0.4	0.1
Basal cell carcinoma (self-reported)	0.1	0.1	0.2	-0.1	0.5
Heart attack/myocardial infarction (self-reported)	0.1	0.1	0.1	-0.4	-0.2
Leg fat mass (left)	0.1	0.4	0.6	0.8	0.3
Crohns Disease (2017)	0.0	0.0	0.1	0.3	0.1
Irritable Bowel Disease (IBD)	0.0	0.1	0.1	0.4	0.2
Ulcerative Colitis (UC)	0.0	0.0	0.0	0.0	0.1
Verbal and Numeric Reasoning (VNR)	0.0	0.1	0.2	0.5	-0.1
Type 2 Diabetes (T2D) (2012)	0.0	0.0	0.0	-0.1	-0.1
Systolic Blood Pressure	0.0	0.2	0.4	-0.6	0.3
Hair Pigment	0.0	0.2	0.2	-0.4	0.5
Relative age of first facial hair	0.0	0.0	0.1	-0.0	-0.2
Medication: Co-codamol	0.0	0.1	0.1	0.1	-0.3
Trunk fat percentage	0.0	0.2	0.3	0.2	-0.6
Age when periods started (menarche)	0.0	0.0	0.1	0.3	0.1
Heel bone mineral density (BMD) T-score, automated (left)	0.0	0.1	0.1	0.4	-0.2
Qualifications: CSEs or equivalent	0.0	0.0	0.1	-0.1	0.3
Hayfever, allergic rhinitis or eczema	0.0	0.0	0.1	0.1	0.2
Hearing difficulty/problems with background noise	0.0	0.0	0.0	0.0	0.0
Heel bone mineral density (BMD) T-score, automated (right)	0.0	0.0	0.1	-0.2	-0.2
Financial difficulties in last 2 years	0.0	0.0	0.1	0.2	0.2
Falls in the last year	0.0	0.0	0.0	-0.0	-0.1
Breastfed as a baby	0.0	0.0	0.1	0.1	-0.3
Glaucoma (self-reported)	0.0	0.0	0.0	0.2	-0.1
Number of full brothers	0.0	0.0	0.1	-0.0	-0.3
Shortness of breath walking on level ground	0.0	0.0	0.1	0.3	0.0
Whole body fat mass	0.0	0.1	0.2	0.1	-0.4
Leg pain on walking	0.0	0.0	0.0	-0.0	0.2
Commuting to job workplace: Walk	0.0	0.0	0.0	0.0	0.1
Osteoporosis (self-reported)	0.0	0.0	0.0	0.2	-0.2
Medication: Atorvastatin	0.0	0.0	0.1	-0.2	0.0
Age started oral contraceptive pill	0.0	0.0	0.1	-0.3	-0.0
Diastolic blood pressure, automated reading	0.0	0.0	0.0	0.2	0.0

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