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chr10:27,265,641-33,021,290

Best TWAS P=1.32e-32 · Best GWAS P=4.95e-29 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	GTEx	Adipose Subcutaneous	WAC-AS1	0.39	0.46	lasso	5	0.45	1.1e-40	9.7	9.0	1.6e-19	0.91	1.00	0.00	FALSE
2	GTEx	Adipose Visceral Omentum	WAC-AS1	0.21	0.17	enet	16	0.18	2.0e-09	9.6	8.8	1.7e-18	0.88	0.04	0.96	FALSE
3	GTEx	Adrenal Gland	WAC-AS1	0.28	0.19	lasso	4	0.14	7.2e-06	9.7	9.5	1.8e-21	0.91	0.07	0.91	FALSE
4	GTEx	Artery Aorta	ARHGAP12	0.14	0.03	lasso	5	0.05	1.2e-03	-3.5	-5.7	1.0e-08	0.00	0.02	0.79	FALSE
5	GTEx	Artery Aorta	WAC-AS1	0.39	0.38	lasso	6	0.38	3.1e-22	9.7	8.8	1.4e-18	0.90	0.98	0.02	FALSE
6	GTEx	Artery Coronary	WAC-AS1	0.41	0.21	lasso	6	0.19	4.0e-07	9.7	9.8	1.0e-22	0.90	0.15	0.84	FALSE
7	GTEx	Artery Tibial	WAC	0.10	0.00	enet	32	0.00	5.6e-01	-7.9	-5.3	9.0e-08	-0.37	0.08	0.15	FALSE
8	GTEx	Artery Tibial	WAC-AS1	0.44	0.43	lasso	4	0.44	4.0e-37	9.7	8.9	3.6e-19	0.90	1.00	0.00	FALSE
9	GTEx	Brain Hippocampus	WAC-AS1	0.29	0.01	enet	10	-0.01	8.5e-01	9.8	9.6	1.1e-21	0.81	0.04	0.56	FALSE
10	GTEx	Brain Nucleus accumbens basal ganglia	WAC-AS1	0.38	0.07	enet	11	0.08	4.3e-03	9.7	6.1	9.4e-10	0.74	0.05	0.71	FALSE
11	GTEx	Breast Mammary Tissue	WAC-AS1	0.29	0.32	lasso	2	0.31	2.1e-16	9.7	9.7	2.8e-22	0.91	0.40	0.60	FALSE
12	GTEx	Breast Mammary Tissue (Female)	WAC-AS1	0.30	0.30	enet	13	0.33	1.7e-10	9.7	8.6	6.4e-18	0.91	0.18	0.82	FALSE
13	GTEx	Cells EBV-transformed lymphocytes	KIF5B	0.17	0.10	lasso	6	0.05	1.0e-02	-5.9	-6.3	2.9e-10	-0.04	0.07	0.44	TRUE
14	GTEx	Cells EBV-transformed lymphocytes	WAC-AS1	0.45	0.36	enet	12	0.41	1.1e-14	9.7	8.4	6.4e-17	0.85	0.07	0.93	FALSE
15	GTEx	Cells Transformed fibroblasts	KIAA1462	0.36	0.26	lasso	6	0.25	1.6e-18	-6.7	-6.7	2.9e-11	-0.01	0.02	0.98	TRUE
16	GTEx	Cells Transformed fibroblasts	WAC-AS1	0.58	0.62	lasso	12	0.64	9.7e-62	9.7	9.5	2.8e-21	0.92	0.97	0.03	FALSE
17	GTEx	Colon Sigmoid	WAC-AS1	0.36	0.23	lasso	9	0.22	2.6e-08	9.7	9.1	7.0e-20	0.88	0.39	0.60	FALSE
18	GTEx	Colon Transverse	WAC-AS1	0.36	0.17	enet	16	0.31	3.6e-15	6.6	7.2	5.9e-13	0.76	0.20	0.80	FALSE
19	GTEx	Esophagus Gastroesophageal Junction	WAC-AS1	0.37	0.16	lasso	6	0.20	9.1e-08	11.2	9.6	5.2e-22	0.91	0.02	0.98	FALSE
20	GTEx	Esophagus Mucosa	WAC-AS1	0.52	0.44	lasso	16	0.51	1.2e-38	9.7	7.9	2.4e-15	0.86	0.72	0.28	FALSE
21	GTEx	Esophagus Muscularis	WAC-AS1	0.37	0.29	enet	32	0.38	5.5e-24	9.7	7.6	2.7e-14	0.80	0.09	0.91	FALSE
22	GTEx	Heart Atrial Appendage	WAC-AS1	0.18	0.12	enet	6	0.15	2.5e-07	9.7	9.2	2.5e-20	0.85	0.20	0.79	FALSE
23	GTEx	Heart Left Ventricle	WAC-AS1	0.39	0.08	lasso	8	0.20	1.3e-10	6.6	5.9	3.4e-09	0.67	0.12	0.88	FALSE
24	GTEx	Liver	WAC-AS1	0.37	0.34	lasso	3	0.34	3.1e-10	9.7	9.7	2.7e-22	0.90	0.08	0.92	FALSE
25	GTEx	Lung	WAC-AS1	0.32	0.13	enet	26	0.24	4.7e-18	9.7	8.6	1.2e-17	0.86	0.03	0.97	FALSE
26	GTEx	Muscle Skeletal	WAC-AS1	0.29	0.15	enet	26	0.22	8.7e-21	6.6	5.4	5.8e-08	0.70	0.59	0.41	FALSE
27	GTEx	Nerve Tibial	WAC-AS1	0.45	0.55	lasso	5	0.56	1.4e-46	9.7	9.4	3.5e-21	0.92	1.00	0.00	FALSE
28	GTEx	Pancreas	WAC-AS1	0.45	0.33	lasso	8	0.34	6.4e-15	9.6	9.3	1.7e-20	0.92	0.08	0.92	FALSE
29	GTEx	Skin Not Sun Exposed Suprapubic	KIF5B	0.15	0.03	enet	12	0.05	6.5e-04	-3.2	-5.3	1.5e-07	0.08	0.28	0.04	FALSE
30	GTEx	Skin Not Sun Exposed Suprapubic	WAC-AS1	0.48	0.48	enet	37	0.56	6.1e-37	9.7	7.9	3.2e-15	0.86	0.44	0.56	FALSE
31	GTEx	Skin Sun Exposed Lower leg	WAC-AS1	0.34	0.39	enet	21	0.45	7.7e-41	9.7	7.5	9.0e-14	0.86	1.00	0.00	FALSE
32	GTEx	Stomach	WAC-AS1	0.39	0.31	lasso	8	0.33	1.1e-16	9.7	8.7	2.8e-18	0.89	0.06	0.94	FALSE
33	GTEx	Testis	WAC	0.23	0.05	enet	11	0.09	1.3e-04	-4.4	-6.5	1.1e-10	-0.30	0.60	0.02	FALSE
34	GTEx	Testis	WAC-AS1	0.45	0.47	lasso	3	0.48	4.3e-24	9.7	9.7	2.2e-22	0.91	0.98	0.02	FALSE
35	GTEx	Thyroid	WAC-AS1	0.21	0.13	enet	12	0.20	1.6e-15	9.7	7.0	2.9e-12	0.86	0.32	0.68	FALSE
36	GTEx	Vagina	WAC-AS1	0.55	0.25	lasso	5	0.22	1.0e-05	9.7	10.7	1.0e-26	0.85	0.05	0.92	FALSE
37	METSIM	Adipose	ARHGAP12	0.04	0.03	lasso	2	0.02	2.6e-04	5.5	-5.4	5.3e-08	0.04	0.31	0.06	FALSE
38	METSIM	Adipose	MKX	0.08	0.10	lasso	5	0.09	2.4e-13	6.9	-7.0	3.6e-12	-0.04	1.00	0.00	TRUE
39	ROSMAP	Brain Pre-frontal Cortex	BAMBI	0.07	0.05	lasso	3	0.04	2.8e-06	5.7	6.2	5.2e-10	0.54	0.93	0.04	FALSE
40	ROSMAP	Brain Pre-frontal Cortex	WAC	0.21	0.29	lasso	5	0.29	5.9e-37	11.1	11.4	5.1e-30	0.99	0.01	0.99	FALSE
41	ROSMAP	Brain Pre-frontal Cortex	KIF5B	0.06	0.02	lasso	2	0.03	5.6e-05	-3.9	5.2	2.5e-07	0.00	0.21	0.22	FALSE
42	ROSMAP	Brain Pre-frontal Cortex	WAC-AS1	0.39	0.35	bslmm	570	0.49	1.8e-72	6.6	5.9	3.6e-09	0.68	1.00	0.00	FALSE
43	YFS	Blood	WAC	0.06	0.08	bslmm	649	0.08	2.2e-24	11.0	-10.9	1.5e-27	-0.99	0.01	0.99	FALSE
44	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	ZNF438	0.10	0.04	lasso	5	0.04	5.9e-05	3.1	5.1	3.1e-07	0.01	0.25	0.28	FALSE
45	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	ZNF438	0.04	0.02	lasso	5	0.03	6.8e-04	-6.5	6.6	5.3e-11	-0.01	0.07	0.60	TRUE
46	The Cancer Genome Atlas	Brain Lower Grade Glioma	ZNF438	0.09	0.03	enet	10	0.03	7.1e-05	2.0	5.2	2.0e-07	-0.01	0.52	0.06	FALSE
47	The Cancer Genome Atlas	Lung Adenocarcinoma	ZNF438	0.07	0.03	lasso	5	0.04	1.9e-05	4.1	6.3	2.1e-10	0.01	0.01	0.99	FALSE
48	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	WAC	0.11	0.04	blup	83	0.07	1.3e-03	11.2	8.8	1.1e-18	0.91	0.01	0.87	FALSE
49	The Cancer Genome Atlas	Prostate Adenocarcinoma	WAC	0.07	0.02	blup	83	0.06	8.7e-07	1.5	7.8	8.1e-15	0.76	0.04	0.95	FALSE
50	The Cancer Genome Atlas	Thyroid Carcinoma	WAC	0.06	0.04	lasso	3	0.03	4.2e-04	11.1	11.9	1.3e-32	0.98	0.01	0.94	TRUE