Best TWAS P=8.88e-17 · Best GWAS P=4.66e-16 conditioned to 0.000334
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | CHST3 | 0.12 | 0.12 | lasso | 6 | 0.11 | 1.1e-13 | 7.2 | 7.8 | 4.5e-15 | 0.96 | 0.08 | 0.92 | FALSE |
| 2 | GTEx | Adrenal Gland | SPOCK2 | 0.44 | 0.46 | lasso | 15 | 0.46 | 3.5e-18 | -5.4 | 6.4 | 2.0e-10 | 0.70 | 0.99 | 0.01 | FALSE |
| 3 | GTEx | Adrenal Gland | DNAJB12 | 0.18 | 0.06 | lasso | 5 | 0.10 | 2.2e-04 | 4.2 | 6.0 | 1.8e-09 | 0.51 | 0.22 | 0.61 | FALSE |
| 4 | GTEx | Breast Mammary Tissue | DNAJB12 | 0.05 | 0.04 | enet | 18 | 0.08 | 6.3e-05 | 4.3 | 5.8 | 5.1e-09 | 0.28 | 0.31 | 0.03 | FALSE |
| 5 | GTEx | Breast Mammary Tissue (Male) | SPOCK2 | 0.17 | -0.01 | enet | 41 | -0.01 | 6.8e-01 | -3.8 | -5.3 | 9.9e-08 | -0.50 | 0.05 | 0.15 | FALSE |
| 6 | GTEx | Esophagus Muscularis | DNAJB12 | 0.07 | 0.07 | lasso | 3 | 0.06 | 2.6e-04 | 4.1 | 5.4 | 7.0e-08 | 0.48 | 0.47 | 0.14 | FALSE |
| 7 | GTEx | Muscle Skeletal | SPOCK2 | 0.08 | 0.03 | lasso | 3 | 0.05 | 2.5e-05 | -4.1 | -6.3 | 2.3e-10 | -0.73 | 0.38 | 0.59 | FALSE |
| 8 | GTEx | Stomach | ASCC1 | 0.20 | 0.02 | lasso | 5 | 0.02 | 3.1e-02 | 3.6 | 5.2 | 1.6e-07 | 0.40 | 0.24 | 0.05 | FALSE |
| 9 | METSIM | Adipose | MICU1 | 0.08 | 0.07 | blup | 406 | 0.09 | 4.5e-13 | 4.3 | 5.9 | 3.8e-09 | 0.37 | 1.00 | 0.00 | FALSE |
| 10 | METSIM | Adipose | SPOCK2 | 0.06 | 0.06 | lasso | 10 | 0.07 | 1.3e-10 | 7.3 | -6.6 | 3.8e-11 | -0.77 | 0.08 | 0.92 | FALSE |
| 11 | NTR | Blood | SPOCK2 | 0.03 | 0.02 | enet | 10 | 0.02 | 1.2e-07 | -6.1 | -6.2 | 7.7e-10 | -0.67 | 0.98 | 0.02 | FALSE |
| 12 | ROSMAP | Brain Pre-frontal Cortex | CHST3 | 0.15 | 0.18 | lasso | 5 | 0.18 | 1.1e-22 | 8.1 | 8.0 | 1.3e-15 | 1.00 | 0.00 | 1.00 | FALSE |
| 13 | The Cancer Genome Atlas | Breast Invasive Carcinoma | SPOCK2 | 0.02 | 0.01 | blup | 66 | 0.01 | 7.8e-04 | -3.8 | -6.2 | 5.2e-10 | -0.62 | 0.37 | 0.32 | FALSE |
| 14 | The Cancer Genome Atlas | Esophageal Carcinoma | ASCC1 | 0.11 | 0.01 | blup | 58 | 0.02 | 1.0e-01 | -6.2 | 6.0 | 1.5e-09 | 0.66 | 0.02 | 0.58 | FALSE |
| 15 | The Cancer Genome Atlas | Brain Lower Grade Glioma | ASCC1 | 0.07 | 0.05 | blup | 73 | 0.09 | 1.1e-10 | 7.1 | 8.3 | 8.9e-17 | 0.65 | 0.02 | 0.98 | TRUE |
| 16 | The Cancer Genome Atlas | Brain Lower Grade Glioma | CHST3 | 0.11 | 0.04 | blup | 99 | 0.04 | 8.7e-06 | -3.0 | 5.4 | 7.7e-08 | 0.55 | 0.32 | 0.43 | FALSE |
| 17 | The Cancer Genome Atlas | Liver Hepatocellular Carcinoma | CHST3 | 0.10 | 0.03 | blup | 99 | 0.04 | 5.8e-03 | 7.3 | 5.6 | 2.2e-08 | 0.88 | 0.02 | 0.55 | FALSE |
| 18 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | ASCC1 | 0.13 | 0.07 | lasso | 9 | 0.09 | 1.9e-04 | -4.1 | 5.2 | 2.6e-07 | 0.44 | 0.40 | 0.22 | FALSE |
| 19 | The Cancer Genome Atlas | Soft Tissue Sarcoma | SPOCK2 | 0.07 | 0.08 | enet | 11 | 0.07 | 5.4e-05 | 7.5 | -7.6 | 3.0e-14 | -0.68 | 0.01 | 0.98 | FALSE |
| 20 | The Cancer Genome Atlas | Stomach Adenocarcinoma | SPOCK2 | 0.05 | 0.05 | lasso | 1 | 0.02 | 1.2e-02 | -5.4 | 5.4 | 6.8e-08 | 0.56 | 0.09 | 0.16 | FALSE |
| 21 | The Cancer Genome Atlas | Thyroid Carcinoma | CHST3 | 0.05 | 0.03 | lasso | 2 | 0.03 | 4.0e-04 | -3.1 | 5.3 | 9.3e-08 | 0.62 | 0.10 | 0.85 | FALSE |