Hub : Genes

MICU1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0410	0.0170	2.2e-08	0.064	0.062	0.070	0.060	0.071	3.2e-08	5.5e-08	6.2e-09	7.5e-08	4.6e-09
2	GTEx	Adipose Subcutaneous	0.0620	0.0310	7.5e-05	0.047	NA	0.036	NA	0.053	9.2e-05	NA	5.9e-04	NA	3.7e-05
3	GTEx	Artery Tibial	0.0333	0.0166	1.4e-03	0.056	NA	0.027	NA	0.036	3.4e-05	NA	3.0e-03	NA	8.0e-04
4	GTEx	Brain Cortex	0.2710	0.1410	2.9e-03	-0.008	NA	0.004	NA	-0.005	6.2e-01	NA	2.4e-01	NA	4.8e-01
5	GTEx	Cells EBV-transformed lymphocytes	0.1690	0.0720	1.1e-04	0.143	NA	0.133	NA	0.155	2.2e-05	NA	4.4e-05	NA	9.5e-06
6	GTEx	Cells Transformed fibroblasts	0.0820	0.0500	8.7e-04	0.068	NA	0.024	NA	0.058	7.7e-06	NA	6.2e-03	NA	3.9e-05
7	GTEx	Skin Sun Exposed Lower leg	0.0230	0.0130	7.7e-03	0.015	NA	0.000	NA	0.006	1.9e-02	NA	3.3e-01	NA	9.3e-02
8	GTEx	Testis	0.4720	0.0800	2.5e-09	0.038	NA	0.121	NA	0.139	8.4e-03	NA	5.0e-06	NA	9.8e-07
9	METSIM	Adipose	0.0776	0.0283	8.0e-12	0.074	0.088	0.064	0.085	0.076	3.3e-11	4.5e-13	7.2e-10	1.2e-12	1.7e-11
10	ROSMAP	Brain Pre-frontal Cortex	0.0573	0.0253	2.6e-08	0.071	0.066	0.051	0.060	0.075	1.8e-09	7.9e-09	3.9e-07	3.0e-08	5.9e-10

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10
Bipolar Disorder (2018)	0.7	1.1	2.5	-1.3	1.1	1.6	0.5	1.0	1.0	1.0	-0.3	1.1	-0.7
Bipolar Disorder or Schizophrenia	0.1	0.3	0.9	-0.6	0.3	0.9	0.6	0.5	0.2	0.1	-0.2	0.2	-0.8
Depressed Affect (Nagel 2018)	0.6	1.3	7.5	0.1	-0.1	0.0	2.7	0.1	-0.4	-0.4	1.9	-1.2	-0.1
Depression (Nagel 2018)	0.3	0.4	2.5	-0.1	0.6	0.2	1.6	0.4	0.6	0.0	0.8	0.0	-0.1
Intelligence (Savage-Jansen 2018)	5.3	16.2	20.7	-4.0	4.4	4.2	-2.9	4.3	4.3	4.5	-2.8	4.1	-4.2
Neuroticism (Nagel 2018)	0.2	0.4	3.0	-0.2	0.3	0.4	1.7	0.3	-0.2	-0.2	0.7	-0.5	-0.2
Schizophrenia (2018)	0.1	0.2	0.5	0.0	-0.6	-0.0	0.2	-0.1	-0.6	-0.7	-0.2	-0.6	-0.4
Schizophrenia vs Biploar Disorder	0.2	0.3	1.7	-0.3	0.3	-0.1	1.0	0.2	-0.0	0.2	1.3	-0.3	-0.2
Worry (Nagel 2018)	0.3	0.6	1.4	-0.9	1.1	1.2	0.9	0.8	0.3	0.6	-0.1	0.6	-0.7
Alzheimer’s Disease (in mother)	0.4	0.4	1.0	-0.9	0.6	0.3	-0.5	1.0	0.4	0.7	-0.1	0.8	-0.6
Alzheimer’s Disease (in father)	0.2	0.2	0.5	0.5	-0.3	-0.3	0.7	-0.7	-0.5	-0.2	0.3	-0.7	0.3
Alzheimer’s Disease (including proxy)	0.1	0.1	0.6	0.0	0.5	0.1	0.3	-0.0	0.1	0.8	0.2	0.3	0.0
Crohns Disease (2017)	1.1	2.3	3.7	1.9	-1.5	-1.6	-1.2	-1.7	-1.5	-1.9	-0.3	-1.1	1.8
Irritable Bowel Disease (IBD)	1.0	2.4	4.1	1.8	-1.7	-1.1	-1.1	-1.9	-1.7	-2.0	-0.8	-1.1	1.9
Ulcerative Colitis (UC)	0.5	1.0	1.8	1.0	-1.1	-0.3	-0.8	-1.3	-1.0	-1.2	-0.9	-0.6	1.2
Major Depression (MDD)	0.2	0.2	0.6	-0.8	-0.2	0.4	-0.3	0.4	-0.3	-0.3	-0.8	0.3	-0.4
Reaction Time	0.5	0.9	1.8	0.9	-0.8	-1.3	1.0	-0.6	-1.2	-1.0	1.2	-0.7	0.9
Verbal and Numeric Reasoning (VNR)	4.0	9.6	14.8	-3.1	3.8	3.6	-0.9	3.2	3.4	3.8	-1.6	3.0	-3.2
Breast Cancer	0.5	1.1	5.3	0.3	0.7	0.6	2.0	0.2	0.1	0.7	2.3	-0.5	0.2
Ovarian Cancer	0.3	0.3	1.5	0.0	0.4	0.4	1.2	0.0	0.0	0.1	1.2	-0.2	0.3
Prostate Cancer	1.4	2.0	2.8	-1.4	1.0	1.0	-1.3	1.5	1.5	1.2	-1.7	1.7	-1.6
Age at First Birth	0.9	1.3	2.2	-1.1	1.1	0.9	-1.0	1.1	1.2	1.2	-1.0	1.4	-1.5
Bipolar Disorder (2011)	1.0	1.0	1.7	-1.2	0.8	1.1	-1.2	1.3	0.6	0.7	-0.8	0.9	-1.0
Body Mass Index (BMI) (2010)	0.7	0.9	1.9	-1.4	1.0	0.5	-0.1	1.3	1.1	1.1	0.1	0.7	-1.3
Coronary Artery Disease (CAD)	1.6	1.9	3.3	1.3	-1.7	-1.4	1.3	-1.5	-1.8	-1.5	0.3	-1.3	1.1
Crohns Disease (2012)	0.1	0.2	0.7	0.6	0.2	0.1	-0.5	-0.4	-0.0	-0.4	0.4	-0.1	0.8
Mean Putamen Volume	0.6	0.6	4.0	0.2	0.2	0.1	2.0	-0.3	-0.3	-0.2	1.4	-0.1	0.6
Fasting Glucose	0.5	0.6	1.5	-0.5	0.9	0.5	-0.3	0.4	1.1	1.1	0.0	0.4	-1.2
HbA1C	0.4	0.4	1.7	-0.7	-0.0	0.2	0.0	0.7	0.4	-0.0	-1.3	1.0	-0.8
HDL Cholesterol	1.1	1.9	3.7	-1.5	1.4	1.6	-0.0	0.9	1.1	1.1	-1.9	1.8	-1.4
LDL Cholesterol	1.2	1.8	5.8	1.3	-1.2	-1.8	-0.2	-1.6	-0.9	-1.0	-2.4	0.8	1.1
Lupus	0.6	1.0	4.4	-0.6	-0.1	0.0	-1.6	0.7	0.1	0.2	-2.1	1.0	-1.0
Neuroticism (2016)	1.1	1.5	3.7	0.7	-1.1	-0.7	1.9	-0.8	-1.5	-1.4	1.4	-1.3	1.0
Primary Biliary Cirrhosis	0.8	1.1	4.3	-0.8	0.0	-0.4	-1.6	1.0	0.7	0.3	-2.1	1.1	-1.1
Rheumatoid Arthritis	0.7	0.9	2.1	1.1	-0.9	-0.8	0.6	-1.5	-1.4	-0.8	-0.3	-0.1	1.1
Schizophrenia (2014)	0.6	1.4	3.3	-1.3	1.0	1.3	-0.6	1.4	1.0	0.9	-1.2	0.9	-1.8
Triglycerides	2.6	4.3	7.4	1.2	-2.3	-2.2	-0.5	-1.9	-2.3	-2.2	2.7	-2.7	1.6
Type 2 Diabetes (T2D) (2012)	0.4	0.5	1.7	-0.4	-0.5	-1.3	-0.6	0.9	0.3	0.1	-0.9	-0.4	-0.8
Ulcerative Colitis	0.3	0.4	1.2	0.7	-0.5	-0.1	-0.0	-1.1	-0.5	-0.6	-0.3	-0.5	1.0
Blood Eosinophil Count	0.1	0.7	1.7	-1.2	0.3	0.8	0.4	1.1	0.7	0.5	1.3	-0.3	-0.8
Blood Platelet Count	0.0	0.3	0.9	0.4	-0.4	0.4	0.2	-0.9	-0.4	-0.4	-0.6	0.3	0.9
Blood Red Count	0.4	4.1	14.7	1.3	-2.8	-3.8	-0.8	-0.9	-2.2	-2.8	-0.6	-1.3	1.0
Blood White Count	0.0	0.2	0.5	-0.3	-0.5	0.1	-0.3	-0.5	0.2	-0.4	-0.7	-0.2	0.4
Heel T-Score	0.1	0.6	2.9	-0.6	0.5	0.7	1.7	0.1	-0.4	0.5	1.4	0.0	-0.3
BMI	0.7	4.1	10.0	1.6	-1.7	-1.7	3.2	-1.7	-1.1	-1.6	3.0	-2.1	1.7
Height	1.1	20.6	34.7	-4.6	4.7	4.2	-2.6	4.5	4.7	4.7	-4.3	5.9	-4.5
Waist Hip Ratio (WHR)	0.5	2.1	5.4	1.2	-1.7	-2.3	-0.3	-1.4	-1.3	-1.9	-1.1	0.5	1.6
Systolic Blood Pressure	0.3	1.4	6.9	-0.3	1.5	1.3	0.9	-0.2	0.3	1.1	2.6	-0.8	0.1
Smoking Status	2.8	6.6	11.5	2.7	-3.2	-3.1	0.5	-3.4	-2.9	-2.9	-1.0	-1.6	2.5
Allergy or Eczema	0.2	0.4	2.6	-0.3	-0.3	-0.5	-0.4	0.8	-0.3	-0.1	1.6	-0.6	-0.2
Cardiovascular Disease	1.0	3.2	6.0	1.5	-1.1	-0.5	2.5	-2.4	-1.5	-1.5	2.0	-2.2	1.8
Hypothyroidism (self reported)	0.4	1.0	7.2	0.4	-0.1	0.4	2.7	-0.8	-0.5	-0.0	0.8	-0.0	0.7
Respiratory disease	0.4	0.9	1.9	-1.3	0.6	0.6	-0.5	1.2	1.4	0.9	0.9	-0.0	-1.0
Type 2 Diabetes (T2D) (2018)	0.3	0.6	2.5	-0.3	0.7	0.8	0.4	0.2	1.6	0.7	-0.6	0.6	-0.8
Lung FEV1/FVC ratio	0.6	3.2	16.4	-1.0	1.0	0.4	-0.9	1.0	0.9	0.7	-4.0	3.0	-1.0
Lung FVC	2.4	12.3	23.1	-3.5	4.8	4.3	-0.4	3.1	3.8	4.2	-2.0	3.9	-2.7
Neuroticism	0.4	0.9	6.6	-0.0	-0.1	0.4	2.6	-0.1	-0.9	-0.6	0.6	-0.7	0.1
Chronotype (morning person)	1.1	2.6	6.2	1.5	-0.4	-0.6	2.3	-1.5	-1.0	-0.6	2.5	-2.3	1.9
Hair Pigment	0.8	22.7	37.9	-5.2	6.2	5.1	-0.6	4.8	5.8	5.9	-1.1	4.8	-4.5
Tanning	0.9	11.4	15.1	3.9	-3.7	-3.4	2.2	-3.6	-3.1	-3.7	2.5	-3.7	3.6
Hand grip strength (left)	0.2	0.5	1.4	-0.9	0.6	1.2	-0.7	0.5	0.4	0.5	0.6	-0.3	-0.9
Number of treatments/medications taken	0.4	0.8	5.3	0.3	0.4	0.8	2.3	-0.9	-0.0	-0.2	0.4	0.6	0.8
Average weekly spirits intake	0.3	0.3	0.8	0.3	-0.1	0.4	0.9	-0.6	-0.8	-0.6	0.9	-0.4	0.5
Sensitivity / hurt feelings	0.3	0.5	1.2	-0.9	0.5	1.1	0.7	0.8	0.4	0.6	-0.3	0.5	-0.8
Frequency of depressed mood in last 2 weeks	0.2	0.3	1.3	0.5	0.1	-0.1	1.1	-0.1	-0.2	-0.5	-0.3	0.5	0.5
Hearing difficulty/problems: Yes	0.6	0.9	5.6	-0.7	0.2	0.6	-0.6	0.3	0.0	0.0	-2.4	1.4	-0.3
Relative age of first facial hair	0.2	0.5	1.6	0.7	-1.0	-1.3	0.5	-0.5	-0.2	-0.6	0.4	-0.8	0.5
Other serious medical condition/disability diagnosed by doctor	0.2	0.2	1.7	0.2	-0.2	0.0	1.3	-0.4	-0.1	-0.4	-0.2	0.1	0.5
Ever used hormone-replacement therapy (HRT)	0.6	0.8	2.0	-0.6	1.0	0.9	1.2	0.3	0.8	0.8	-0.9	1.4	-0.1
Ever had hysterectomy (womb removed)	3.2	3.6	5.7	-2.0	2.4	2.1	0.1	2.0	2.0	2.3	-0.8	2.2	-1.6
Systolic blood pressure, automated reading	0.5	1.4	7.8	0.2	1.1	1.3	0.6	-0.3	0.5	0.8	2.8	-1.2	0.8
Eye problems/disorders: Diabetes related eye disease	1.6	1.8	3.1	-1.1	1.6	1.6	-0.7	0.8	1.7	1.7	-0.8	1.6	-1.2
Angina	0.7	1.0	1.9	-1.2	1.0	1.1	0.4	0.4	1.4	1.0	-0.9	1.2	-0.8
Medication for hormone replacement therapy	1.0	1.1	2.2	-1.2	0.9	1.1	-0.0	1.0	1.3	0.8	-0.8	1.5	-1.0
Vitamin and mineral supplements	0.9	1.3	6.0	0.4	0.2	0.5	1.7	-0.7	-0.5	-0.4	2.5	-1.0	1.2
Supplements: Zinc	0.3	0.3	0.7	-0.3	0.8	0.6	0.2	0.4	0.8	0.6	-0.4	0.3	-0.5
Medication: Co-codamol	1.1	1.2	3.4	0.7	-1.0	-0.9	0.5	-0.7	-0.6	-0.9	1.9	-1.8	1.1
Medication: Metformin	1.2	1.7	3.5	-1.4	1.3	1.8	-0.1	1.1	1.9	1.0	-0.9	1.1	-1.6
Diabetes (father)	1.6	2.0	3.9	-1.5	1.4	1.0	-1.3	1.6	2.0	1.4	-0.7	1.2	-1.7
Diabetes (mother)	1.8	2.2	5.0	1.7	-2.2	-1.1	-0.8	-1.9	-1.4	-1.9	0.1	-1.2	1.4
Severe depression (siblings)	0.3	0.3	1.5	0.5	0.7	0.3	-1.2	0.3	0.5	0.4	0.2	0.4	0.3
Pack years adult smoking proportion	0.1	0.2	1.1	0.1	0.1	0.7	1.0	-0.3	0.4	0.0	0.6	-0.1	0.1
Impedance of leg (right)	0.1	0.7	3.2	0.3	-0.3	-0.7	-1.8	-0.3	-0.8	-0.6	-1.0	-0.6	0.6
Leg fat-free mass (left)	0.1	0.8	1.7	-0.8	0.6	0.8	0.9	1.1	1.1	0.7	0.6	1.3	-0.9
Trunk fat percentage	0.1	0.2	1.1	0.3	-0.6	-1.0	-0.2	0.3	0.4	-0.2	0.5	-0.1	0.4
Hand grip strength (right)	0.4	1.0	2.1	-1.1	1.1	1.0	-0.3	1.2	1.1	1.0	0.8	0.3	-1.5
Townsend deprivation index at recruitment	0.3	0.4	2.2	-0.4	-0.1	-0.7	-1.5	0.1	0.7	0.3	-0.5	0.6	-0.3
Current tobacco smoking	2.6	4.2	7.6	2.3	-2.5	-2.1	0.7	-2.8	-2.1	-2.4	0.5	-1.9	2.1
Average weekly fortified wine intake	1.1	1.3	2.4	-1.3	1.6	0.8	-0.0	1.3	1.4	1.4	0.3	0.2	-1.5
Maternal smoking around birth	0.8	1.1	2.4	1.0	-1.0	-0.9	1.4	-0.8	-0.5	-0.7	1.1	-1.6	1.0
Fed-up feelings	0.7	1.4	4.7	0.6	-0.6	-0.5	2.2	-0.4	-0.7	-0.5	2.1	-1.6	0.3
Frequency of unenthusiasm / disinterest in last 2 weeks	0.3	0.4	3.5	0.2	0.4	0.1	1.9	-0.2	0.4	-0.0	0.5	0.1	0.1
Relative age voice broke	0.6	0.9	2.9	0.4	-1.3	-1.4	0.5	-0.3	-0.6	-0.9	0.9	-1.7	0.2
Taking other prescription medications	0.0	0.0	0.1	0.2	-0.2	-0.3	0.3	-0.0	0.3	-0.0	0.0	0.1	0.2
Age when periods started (menarche)	2.7	6.4	13.7	2.8	-3.2	-3.7	-0.8	-2.3	-2.7	-3.2	0.2	-2.2	2.1
Bilateral oophorectomy (both ovaries removed)	1.6	1.9	2.9	-1.2	1.6	1.7	1.4	1.3	1.6	1.6	1.2	0.8	-0.9
Heel bone mineral density (BMD) T-score, automated (left)	0.7	1.7	3.4	0.8	-1.2	-0.1	1.2	-1.3	-1.6	-1.1	1.8	-1.8	0.9
Tinnitus: Yes, but not now, but have in the past	0.4	0.4	2.7	0.2	-0.4	-0.7	-0.8	-0.3	-0.4	-0.2	-1.6	0.4	0.3
Qualifications: CSEs or equivalent	0.6	0.8	1.7	0.9	-0.7	0.3	0.5	-0.9	-1.3	-0.9	1.0	-1.1	0.6
Serious illness, injury or assault to yourself	2.3	2.8	4.0	1.8	-1.8	-1.6	2.0	-2.0	-1.6	-1.9	0.0	-1.2	1.9
High blood pressure	0.2	0.5	2.7	0.1	0.1	0.7	1.6	-0.8	0.0	-0.1	0.6	-1.0	0.4
Hayfever, allergic rhinitis or eczema	0.4	0.8	2.3	0.3	-1.0	-1.3	0.1	0.1	-1.0	-0.9	1.5	-1.0	0.5
Multivitamins +/- minerals	1.5	1.9	6.4	-0.9	0.5	0.2	-1.5	1.4	1.0	0.9	-2.5	1.7	-1.8
Stomach or abdominal pain in last month	0.1	0.1	0.5	-0.4	-0.3	0.4	0.7	0.2	0.0	-0.4	0.5	-0.1	0.0
Supplements: Glucosamine	0.7	0.9	1.6	-0.8	1.0	1.2	0.0	1.0	1.2	1.1	0.0	0.7	-1.0
Diverticular disease/diverticulitis (self-reported)	0.8	0.9	1.8	-1.3	1.3	1.3	0.1	0.9	0.9	1.1	0.3	0.8	-0.7
Medication: Atenolol	0.6	0.8	2.8	1.2	-0.2	-0.0	1.7	-1.5	-0.3	-0.4	-0.1	0.1	1.1
Medication: Levothyroxine sodium	0.5	0.9	5.4	1.1	-0.2	0.2	2.3	-0.8	-0.3	0.0	0.7	-0.1	1.0
Sitting height	0.9	6.6	8.6	-2.4	2.6	2.9	-2.7	2.7	2.4	2.6	-1.8	2.9	-2.4
Chronic bronchitis/emphysema (father)	0.2	0.3	0.7	0.4	-0.6	-0.4	-0.5	-0.6	-0.5	-0.3	0.3	-0.8	0.5
High blood pressure (mother)	0.3	0.4	2.1	-0.6	0.9	1.4	-0.1	0.3	0.1	0.7	0.4	0.4	-0.4
Body mass index (BMI)	0.5	2.2	7.2	1.2	-1.3	-1.4	2.7	-0.9	-0.5	-1.1	2.0	-1.1	1.2
Impedance of leg (left)	0.2	1.1	3.4	0.6	-0.8	-1.2	-1.8	-0.6	-1.1	-0.9	-0.8	-1.0	0.9
Leg predicted mass (left)	0.2	0.8	1.7	-0.8	0.6	0.8	0.9	1.2	1.0	0.7	0.6	1.3	-1.0
Trunk fat mass	0.0	0.1	0.5	-0.1	-0.2	-0.5	-0.0	0.6	0.7	0.0	0.4	0.4	0.1
Waist circumference	0.2	0.6	1.7	0.5	-0.8	-1.1	1.3	-0.1	0.0	-0.7	0.9	0.0	0.6
Number of incorrect matches in round	0.1	0.2	0.6	0.3	0.2	0.0	-0.3	-0.6	-0.2	-0.2	-0.5	0.8	0.6
Past tobacco smoking	1.1	2.0	5.0	-1.7	1.5	1.3	0.1	2.2	1.3	1.1	1.6	0.4	-1.6
Alcohol usually taken with meals	3.0	4.8	8.1	-1.9	2.1	2.3	-1.6	1.6	2.2	2.2	-2.8	2.9	-2.0
Nervous feelings	0.2	0.4	0.9	-0.7	0.7	0.5	-1.0	0.9	0.3	0.5	-0.3	0.8	-0.3
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.5	1.0	-0.4	0.8	1.0	0.9	0.1	0.8	0.5	-0.8	0.9	0.1
Hearing difficulty/problems with background noise	0.1	0.2	0.6	0.3	-0.4	-0.4	-0.4	-0.4	-0.8	-0.4	-0.1	-0.8	0.5
Hair/balding pattern: Pattern 2	0.7	0.9	4.0	0.3	-0.1	-0.3	2.0	-0.2	-0.0	0.1	1.9	-1.1	0.1
Had menopause	0.2	0.3	0.6	0.7	-0.3	-0.4	0.7	-0.6	-0.2	-0.1	-0.7	-0.0	0.6
Had other major operations	0.3	0.4	0.8	-0.6	0.8	0.9	0.3	0.5	0.6	0.9	-0.1	0.6	-0.5
Forced vital capacity (FVC)	3.2	12.3	18.4	-3.3	4.3	3.7	-1.6	3.5	3.9	4.1	-2.2	4.2	-3.3
Heel bone mineral density (BMD) T-score, automated (right)	0.9	2.1	3.7	0.9	-1.4	-0.4	1.5	-1.4	-1.9	-1.4	1.7	-1.8	1.2
Ever unenthusiastic/disinterested for a whole week	0.6	0.7	2.4	0.5	-0.4	-1.4	-1.5	0.2	0.2	-0.1	-1.5	-0.1	-0.3
Qualifications: None of the above	2.0	4.3	12.3	2.2	-1.3	-1.6	1.3	-1.9	-1.3	-1.4	3.5	-2.3	2.6
Financial difficulties in last 2 years	1.9	2.6	4.0	1.9	-1.5	-1.7	1.4	-1.7	-1.3	-1.4	1.1	-2.0	1.9
Mouth/teeth dental problems	1.0	1.5	3.5	-1.4	1.5	0.7	-1.2	1.5	1.1	1.3	0.2	0.4	-1.9
Heart attack	0.1	0.2	0.8	-0.0	0.0	0.2	0.3	-0.3	0.3	0.1	0.9	-0.7	0.1
Allergy	0.7	1.7	4.1	-0.8	1.5	1.5	-0.7	0.6	1.3	1.4	-2.0	1.6	-1.0
Pain all over the body in last month	2.2	2.4	3.6	1.6	-1.5	-1.3	1.9	-1.8	-1.1	-1.6	1.3	-1.4	1.9
Diabetes (self-reported)	2.1	3.2	6.4	-1.6	2.0	2.2	0.0	1.6	2.5	1.7	-1.3	1.9	-1.9
Hayfever/allergic rhinitis (self-reported)	0.4	0.5	1.1	1.1	-0.6	-1.0	-0.3	-0.9	-0.4	-0.3	-0.4	-0.6	0.9
Medication: Ramipril	1.2	1.5	4.4	1.2	-0.7	-0.5	1.2	-1.3	-0.7	-1.0	1.6	-2.1	1.2
Medication: Simvastatin	0.7	1.1	3.5	1.0	0.5	0.5	1.9	-1.4	-0.3	0.1	1.4	-0.1	1.4
Fluid intelligence score	3.0	6.2	8.9	-2.6	2.9	3.0	-0.6	2.5	2.6	2.9	-1.5	2.7	-2.6
Illnesses of siblings	0.4	0.6	2.6	0.2	-1.0	-1.6	-0.3	0.2	-1.1	-1.1	-0.1	-0.0	-0.4
Neuroticism score	0.3	0.5	3.8	-0.5	0.3	0.5	2.0	0.5	-0.4	-0.1	0.3	-0.2	-0.5
Weight	0.1	0.3	1.0	-0.4	0.1	-0.0	1.0	0.7	0.8	0.2	0.7	0.7	-0.3
Impedance of arm (right)	0.7	3.0	16.9	-0.8	0.5	-0.3	-4.1	1.3	0.3	0.6	-2.8	1.3	-0.9
Arm fat percentage (right)	0.2	0.8	1.7	0.8	-1.0	-1.3	1.1	-0.2	-0.3	-0.9	1.3	-0.6	0.9
Trunk fat-free mass	0.2	0.9	2.2	-1.0	0.8	1.4	0.9	0.9	0.9	0.6	0.1	1.5	-1.0
Hip circumference	0.1	0.5	1.6	-0.5	0.4	0.4	0.6	1.2	1.1	0.7	0.5	0.5	-0.8
Time employed in main current job	0.1	0.2	0.5	0.1	-0.7	-0.2	-0.5	-0.5	-0.2	-0.4	-0.7	-0.1	0.2
Alcohol intake versus 10 years previously	6.7	10.0	15.6	3.9	-3.7	-3.4	0.9	-3.5	-3.3	-3.6	1.3	-3.0	3.5
Father’s age at death	0.7	0.9	4.8	-1.1	0.2	0.1	-2.2	1.0	0.1	0.1	-0.9	0.5	-0.9
Worrier / anxious feelings	1.1	2.1	3.6	-1.6	1.5	1.9	-0.0	1.4	0.9	1.1	-1.9	1.6	-1.6
Frequency of tiredness / lethargy in last 2 weeks	0.9	1.4	3.5	0.9	-1.2	-1.1	1.9	-0.9	-1.0	-1.3	1.1	-1.1	1.2
Falls in the last year	3.8	5.1	8.5	2.5	-2.6	-2.4	1.1	-2.4	-2.2	-2.9	0.3	-1.9	2.9
Hair/balding pattern: Pattern 3	0.3	0.5	1.8	0.6	-0.8	-0.8	-0.7	-0.5	-0.5	-0.4	-1.3	0.2	0.1
Number of live births	1.0	1.4	2.5	-1.1	1.3	0.9	-1.0	1.3	1.6	1.4	-0.7	0.8	-1.3
Forced expiratory volume in 1-second (FEV1)	3.2	10.9	18.2	-2.9	4.0	3.1	-1.3	3.2	3.6	3.8	-2.9	4.3	-3.0
Pulse rate	0.5	0.8	4.5	0.2	-0.7	0.2	-0.8	-0.6	-0.8	-0.8	-2.1	0.2	0.5
Happiness	0.1	0.1	0.8	0.0	0.1	0.1	-0.3	0.0	-0.1	-0.2	-0.9	0.4	0.2
Noisy workplace	0.3	0.3	1.4	0.2	-0.5	-0.5	-1.1	-0.0	0.0	-0.4	0.3	-1.2	0.1
Qualifications: A levels/AS levels or equivalent	1.9	4.2	9.1	-2.0	1.8	1.9	-1.5	2.2	1.5	1.9	-3.0	2.5	-1.8
Serious illness, injury or assault of a close relative in last 2 years	0.4	0.4	1.8	-0.3	-0.2	-0.4	-1.1	0.6	0.2	-0.2	-1.3	0.4	-0.5
Mouth/teeth dental problems: Dentures	1.0	1.7	3.5	1.5	-0.8	0.5	1.9	-1.8	-1.2	-0.9	0.6	-0.8	1.9
Asthma	0.2	0.4	0.8	-0.8	-0.2	-0.4	-0.9	0.9	0.6	0.0	0.7	-0.2	-0.5
Medication: Ibuprofen (e.g. Nurofen)	1.2	1.5	14.0	-0.3	0.4	0.7	3.7	-0.1	0.0	0.0	0.7	0.1	-0.0
Medication: Cholesterol lowering	0.6	1.0	2.4	-0.5	1.6	1.2	0.6	0.2	1.4	1.4	-0.3	1.0	-0.3
Depression (self-reported)	0.3	0.4	1.3	0.2	-0.6	-0.8	-1.1	0.2	-0.3	-0.7	-0.6	0.5	0.0
Medication: Lansoprazole	0.5	0.6	1.8	0.7	-0.8	-0.5	0.3	-1.3	-0.7	-0.9	0.3	-0.7	0.6
Prospective memory result	0.3	0.3	1.0	0.5	0.6	0.3	0.5	-0.3	1.0	0.7	0.7	-0.7	-0.0
Lung cancer (father)	1.2	1.4	3.2	1.1	-0.8	-1.5	1.8	-0.7	-0.7	-0.8	1.7	-1.1	1.0
Illnesses of mother	0.6	0.7	5.6	0.5	-0.7	-2.4	0.5	0.1	-0.1	-0.5	-0.1	-0.5	0.0
Forced expiratory volume in 1-second (FEV1), Best measure	2.9	9.1	13.0	-2.6	3.6	2.8	-1.2	2.9	3.5	3.4	-3.1	3.6	-2.6
Pulse wave Arterial Stiffness index	0.4	0.5	2.2	-1.1	0.2	0.2	-1.5	0.7	0.3	0.3	-0.5	0.4	-0.7
Impedance of arm (left)	1.0	4.6	18.4	-1.6	1.3	0.4	-4.3	2.2	1.1	1.4	-3.0	1.8	-1.7
Arm fat mass (right)	0.2	0.8	2.5	0.7	-1.0	-1.0	1.4	-0.2	-0.2	-0.8	1.6	-0.5	0.8
Trunk predicted mass	0.1	0.8	1.8	-0.9	0.7	1.3	1.0	0.8	0.7	0.5	0.1	1.4	-0.9
Standing height	0.9	8.5	12.7	-3.0	2.6	2.5	-3.4	3.2	2.5	2.5	-2.6	3.6	-2.9
Length of working week for main job	3.3	3.6	6.2	1.8	-2.1	-1.3	1.9	-2.5	-2.5	-2.4	0.3	-1.3	1.9
Exposure to tobacco smoke at home	1.3	1.5	9.3	0.1	-0.7	-1.1	-3.0	0.4	-0.0	-0.3	-1.8	0.3	-0.1
Breastfed as a baby	3.5	4.3	5.9	-2.3	1.8	1.2	-2.0	2.4	2.2	2.2	-2.1	2.0	-2.4
Tense / ‘highly strung’	0.5	0.8	1.6	0.4	-0.9	-0.7	1.3	-0.7	-1.3	-1.2	-0.3	-0.7	1.0
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.4	1.1	-0.0	0.1	-0.8	0.7	0.5	0.2	0.2	-1.1	1.0	-0.5
Hair/balding pattern: Pattern 4	0.9	2.2	6.4	-1.4	2.1	2.5	-0.1	0.9	1.8	1.9	0.6	0.7	-0.8
Birth weight of first child	0.1	0.2	0.6	0.2	-0.5	-0.1	0.0	-0.7	-0.7	-0.5	0.4	-0.3	0.8
Peak expiratory flow (PEF)	3.8	8.8	12.1	-2.7	2.9	1.4	-2.4	3.3	3.5	3.2	-2.9	3.4	-3.5
Pulse wave reflection index	2.0	2.5	4.7	-1.8	2.0	1.1	-0.7	1.7	1.9	2.2	-0.6	1.4	-1.6
Ever highly irritable/argumentative for 2 days	0.3	0.4	1.9	0.3	-0.5	-1.4	-0.7	-0.0	-0.0	0.0	0.5	-0.7	-0.2
Loud music exposure frequency	1.0	1.1	2.3	-1.1	0.7	0.9	-0.3	0.9	1.0	0.9	-1.5	1.1	-1.4
Qualifications: O levels/GCSEs or equivalent	1.7	2.8	5.4	-1.8	1.4	0.5	-0.9	2.3	1.6	1.7	-1.7	1.8	-2.2
Mouth/teeth dental problems: Bleeding gums	3.2	4.1	6.2	2.0	-2.2	-2.0	1.4	-2.2	-2.2	-2.2	1.6	-1.9	2.5
Blood clot in the leg (DVT)	0.3	0.4	1.1	-0.4	0.8	0.5	0.3	0.4	1.0	0.8	1.1	-0.3	-0.2
Medication: Paracetamol	0.7	1.2	3.4	0.7	-1.1	-0.2	1.9	-1.1	-1.4	-1.2	0.6	-0.4	1.2
Headache pain in last month	0.3	0.5	1.9	-0.0	0.2	1.2	1.4	-0.7	-0.1	-0.1	0.4	0.1	0.9
Medication for cholesterol, blood pressure or diabetes	0.2	0.4	1.4	-0.8	-0.2	-0.5	-0.8	1.2	0.0	0.2	0.0	0.3	-1.0
Glaucoma (self-reported)	1.5	1.8	3.3	-1.3	1.5	1.8	1.0	1.4	1.6	1.6	0.6	1.1	-1.0
Gout (self-reported)	0.3	0.4	1.2	1.1	-0.5	-0.5	0.6	-1.0	0.1	-0.2	-0.8	-0.5	0.5
Hypothyroidism/myxoedema (self-reported)	0.5	1.0	6.6	0.1	0.7	1.3	2.6	-0.1	0.3	0.8	0.5	0.6	0.2
Medication: Amlodipine	0.2	0.2	0.7	-0.1	0.3	0.5	-0.6	0.3	0.4	0.4	0.9	-0.5	-0.5
Medication: Ventolin 100micrograms inhaler	1.1	1.4	3.3	0.9	-1.3	-1.8	-0.1	-0.7	-0.9	-1.2	1.0	-1.8	1.0
Birth weight	0.3	0.7	2.0	0.7	-1.1	-0.6	0.0	-0.7	-1.4	-1.4	-0.4	-0.1	0.7
Chronic bronchitis/emphysema (mother)	0.2	0.3	1.1	0.3	0.1	0.9	-0.3	-0.1	-0.2	-0.1	-0.4	1.0	0.5
High blood pressure (siblings)	0.2	0.3	0.9	-0.1	0.6	0.9	0.1	0.1	0.7	0.8	0.2	-0.3	0.1
Forced vital capacity (FVC), Best measure	3.1	11.4	17.8	-3.0	4.2	3.8	-1.4	3.2	4.0	4.1	-2.5	3.5	-2.9
Body fat percentage	0.1	0.3	1.1	0.3	-0.6	-1.1	0.4	0.2	0.3	-0.4	0.9	-0.4	0.5
Leg fat percentage (right)	0.3	0.9	2.1	0.6	-0.9	-1.2	1.4	-0.5	-0.3	-0.8	1.3	-0.9	1.0
Arm fat-free mass (right)	0.1	0.6	1.8	-0.6	0.3	0.8	1.4	0.6	0.6	0.2	1.2	0.4	-0.5
Exposure to tobacco smoke outside home	0.8	1.0	2.5	-1.3	0.7	0.5	-0.8	1.6	1.0	0.9	-0.6	0.7	-1.4
Comparative body size at age 10	0.1	0.2	0.5	-0.1	-0.0	0.4	0.5	-0.2	-0.7	-0.5	-0.1	0.5	0.1
Number of full brothers	1.4	1.7	3.2	1.5	-1.8	-1.7	0.3	-1.6	-1.1	-1.5	-0.8	-0.8	1.1
Worry too long after embarrassment	0.4	0.7	2.1	-0.9	1.2	1.5	-0.2	0.7	0.2	0.9	-0.5	0.6	-0.9
Seen a psychiatrist for nerves, anxiety, tension or depression	0.3	0.4	0.7	0.6	-0.8	-0.7	0.1	-0.6	-0.8	-0.6	0.8	-0.5	0.7
Wheeze or whistling in the chest in last year	1.1	2.0	4.3	1.1	-2.0	-2.1	0.2	-1.1	-1.5	-1.9	-0.2	-1.4	0.9
Number of children fathered	0.2	0.2	0.7	-0.5	0.3	0.0	0.2	0.3	0.5	0.5	-0.6	0.3	-0.8
Reason for reducing amount of alcohol drunk: Health precaution	0.1	0.2	0.5	-0.4	-0.3	-0.2	0.3	-0.2	-0.6	-0.7	0.2	0.5	0.2
Age at first live birth	0.3	0.6	1.2	-0.5	0.9	0.8	-1.1	0.4	0.4	0.7	-1.1	1.0	-0.4
Pulse wave peak to peak time	0.2	0.2	0.9	0.9	0.0	0.1	1.0	-0.5	-0.0	-0.1	0.1	-0.0	0.4
Health satisfaction	0.4	0.5	0.8	0.9	-0.6	-0.8	0.9	-0.8	-0.4	-0.7	0.7	-0.8	0.6
Shortness of breath walking on level ground	2.6	3.1	10.8	1.3	-0.7	-0.6	3.3	-1.1	-0.8	-0.8	3.3	-2.0	1.0
Qualifications: College or University degree	0.6	1.7	3.9	-1.4	1.0	1.6	-1.2	1.2	0.7	1.2	-2.0	1.1	-1.5
Eye problems/disorders: None of the above	6.9	8.0	12.4	3.5	-2.9	-3.3	1.8	-3.0	-2.7	-2.8	2.0	-2.7	3.1
Mouth/teeth dental problems: Loose teeth	1.6	1.8	3.3	-1.3	1.1	1.6	-1.1	1.0	1.5	1.2	-1.8	1.5	-1.2
Emphysema/chronic bronchitis	0.3	0.3	0.9	0.5	-0.7	-0.4	0.0	-0.7	-0.9	-0.9	0.2	-0.4	0.4
Medication for pain relief, constipation, heartburn	1.0	1.7	14.4	-0.2	0.1	-0.6	-3.8	1.0	0.5	0.5	-0.2	-0.4	-0.7
Neck or shoulder pain in last month	0.2	0.3	1.6	-0.4	0.2	0.8	1.2	0.1	0.5	0.1	-0.3	0.4	-0.0
Medication: Blood pressure	0.1	0.2	0.6	0.4	0.3	0.5	0.1	-0.7	0.2	0.1	-0.8	-0.0	0.2
Angina (self-reported)	0.9	1.2	2.0	-1.4	1.0	1.2	0.2	0.5	1.4	1.0	-1.0	1.4	-1.0
Migraine (self-reported)	4.6	5.7	9.8	-2.6	3.0	3.1	-0.2	2.4	2.3	2.6	-0.9	2.5	-2.5
Medication: Ibuprofen	1.1	1.4	12.3	-0.3	0.4	0.6	3.5	-0.0	0.1	0.1	0.6	0.6	-0.1
Medication: Allopurinol	0.1	0.2	0.6	-0.1	0.2	0.8	0.3	-0.0	0.6	0.3	-0.7	0.3	-0.4
Medication: Omeprazole	0.4	0.4	4.1	-0.1	0.1	0.1	2.0	0.1	0.2	0.4	0.2	-0.1	-0.2
Medication: Seretide 50 evohaler	0.4	0.5	3.6	-0.3	-0.4	0.1	-1.9	0.2	-0.2	-0.2	-0.7	-0.6	-0.1
Mean time to correctly identify matches	0.1	0.1	0.5	0.3	-0.1	-0.7	0.0	-0.3	-0.4	-0.2	0.3	0.4	0.4
Heart disease (mother)	0.5	0.6	1.7	0.9	-0.3	0.4	1.1	-1.3	-0.4	-0.5	-0.0	-0.4	1.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.1	1.3	2.2	0.9	-1.4	-1.4	-1.1	-1.2	-1.5	-1.3	-0.9	-0.7	0.6
Whole body fat mass	0.1	0.3	1.5	-0.1	-0.3	-0.6	0.6	0.5	0.6	-0.1	1.2	-0.0	0.1
Leg fat mass (right)	0.2	0.7	2.8	0.4	-0.7	-0.8	1.4	-0.2	-0.1	-0.7	1.7	-0.6	0.7
Arm predicted mass (right)	0.1	0.7	1.4	-0.9	0.5	1.0	1.2	0.8	0.9	0.4	0.9	0.7	-0.8
Pulse rate, automated reading	0.2	0.6	4.0	-0.0	-0.5	0.0	-0.9	-0.1	-0.5	-0.5	-2.0	0.8	0.0
Alcohol intake frequency.	0.4	0.9	1.7	1.2	-1.0	-1.1	0.8	-1.3	-0.7	-0.8	0.5	-1.0	0.7
Comparative height size at age 10	2.6	14.2	23.3	-3.7	4.4	4.8	-2.8	3.4	3.5	3.8	-2.9	4.6	-3.1
Number of full sisters	0.2	0.3	0.8	-0.6	0.2	-0.4	-0.9	0.7	0.7	0.4	0.3	0.2	-0.5
Suffer from ‘nerves’	1.0	1.6	2.9	-1.3	1.7	1.7	0.8	1.4	1.3	1.4	-0.1	1.4	-1.1
Overall health rating	2.0	4.2	7.9	2.5	-1.4	-0.9	2.5	-2.6	-1.4	-1.8	1.7	-2.0	2.8
Chest pain or discomfort	3.8	5.4	12.0	2.1	-2.9	-3.5	1.7	-2.4	-2.0	-2.8	-0.1	-1.9	2.3
Had major operations	0.3	0.4	1.7	0.6	-0.4	-0.2	1.3	-0.2	-0.4	-0.3	0.3	-0.8	0.5
Age at last live birth	0.4	0.5	2.3	-0.3	0.1	-0.7	-1.5	0.4	0.0	-0.1	-1.3	0.5	-0.3
Family relationship satisfaction	0.3	0.4	1.0	-0.3	1.0	0.5	-0.6	0.5	0.9	0.8	0.1	1.0	-0.1
Leg pain on walking	0.3	0.4	1.4	0.4	-0.5	-1.2	1.2	-0.4	-0.3	-0.5	0.4	-0.6	0.0
Qualifications: NVQ or HND or HNC or equivalent	0.2	0.2	1.0	0.4	-0.3	-0.3	-0.2	-0.5	-0.4	-0.5	-1.0	0.2	0.2
Commuting to job workplace: Car/motor vehicle	0.8	0.9	1.9	-1.4	0.8	0.5	-1.4	1.2	0.6	0.7	-0.2	0.8	-1.1
Illness, injury, bereavement, stress in last 2 years	2.8	3.4	5.1	-1.8	2.3	2.2	-1.3	2.0	1.9	2.2	-0.1	1.9	-1.7
Medication: Aspirin	0.9	1.2	3.3	-0.6	1.4	1.6	1.8	-0.0	1.0	1.0	-0.4	1.2	-0.1
Supplements: Vitamin C	0.3	0.4	1.9	0.3	-0.7	-1.4	-0.1	-0.3	-0.3	-0.5	-0.9	0.1	0.0
Knee pain experienced in last month	0.6	1.0	6.1	-0.4	0.3	0.6	-0.1	-0.0	0.2	0.0	-2.5	1.8	0.1
Hypertension (Self-reported)	0.2	0.5	1.6	-0.1	0.3	0.9	1.2	-0.6	0.3	0.1	0.8	-1.0	0.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.1	0.1	0.4	-0.2	-0.4	-0.2	0.5	0.0	-0.6	-0.3	-0.2	0.1	-0.4
Illnesses of father: Heart disease	1.0	1.4	3.0	1.5	-1.1	-1.3	-0.4	-1.7	-1.0	-1.3	-0.6	-1.3	1.2
Illnesses of siblings: Diabetes	0.2	0.3	1.8	-0.2	-0.2	1.4	-0.1	-0.4	-0.4	-0.3	-0.5	0.1	0.4
Smoking status: Previous	0.6	0.9	2.2	1.2	-0.8	-0.8	-0.1	-1.5	-0.9	-0.6	-1.0	-0.1	1.3
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.3	1.9	-0.5	-0.2	-0.0	-1.4	0.3	0.3	0.1	-0.4	-0.3	-0.7
Whole body fat-free mass	0.2	0.9	1.7	-0.9	0.7	1.2	1.0	1.0	1.0	0.6	0.5	1.3	-0.9
Leg fat-free mass (right)	0.1	0.7	1.3	-0.7	0.5	0.7	0.8	1.0	1.0	0.6	0.6	1.2	-0.9
Arm fat percentage (left)	0.2	0.8	1.7	0.6	-0.9	-1.3	1.2	-0.0	-0.2	-0.7	1.3	-0.6	0.7
Average weekly red wine intake	0.1	0.2	1.0	-0.5	0.0	0.5	0.6	-0.0	0.1	0.0	1.0	-0.1	-0.2
Handedness (chirality/laterality): Left-handed	0.3	0.4	3.1	-0.2	-0.3	-0.2	0.0	-0.2	-0.2	-0.3	-1.8	0.2	-0.1
Mood swings	0.2	0.4	1.8	0.1	-0.4	-0.4	1.3	0.2	-0.8	-0.8	-0.0	0.3	-0.3
Loneliness, isolation	4.0	5.5	16.3	2.1	-1.4	-1.0	4.0	-2.1	-1.9	-1.7	2.8	-2.5	2.7
Long-standing illness, disability or infirmity	1.2	1.8	5.7	-0.8	1.9	1.5	1.1	0.8	2.4	1.8	0.4	0.6	-0.7
Ever had bowel cancer screening	0.2	0.2	0.7	0.1	0.2	0.8	-0.5	0.1	0.4	0.2	-0.5	0.6	0.3
Diabetes diagnosed by doctor	1.4	2.3	5.5	-1.2	1.6	1.6	0.0	1.2	2.4	1.4	-1.5	1.7	-1.6
Ever had stillbirth, spontaneous miscarriage or termination	1.1	1.2	2.4	0.4	-1.3	-1.5	1.0	-1.0	-1.3	-1.4	0.5	-1.1	1.1
Friendships satisfaction	0.5	0.6	2.0	-0.6	0.7	0.4	-0.5	0.7	0.7	0.6	-1.1	1.4	-0.5
Qualifications: nursing, teaching	3.1	4.8	7.4	-2.5	2.1	2.1	-1.5	2.2	2.1	2.3	-2.2	2.1	-2.7
Commuting to job workplace: Walk	0.1	0.1	0.2	-0.1	0.1	0.2	-0.4	0.3	0.1	0.1	-0.1	-0.4	0.3
Eye problems/disorders: Cataract	4.4	5.1	7.6	-2.5	2.3	1.5	-2.3	2.4	2.2	2.1	-2.1	2.8	-2.3
Mouth/teeth dental problems: Mouth ulcers	0.3	0.5	1.4	0.4	-1.0	-1.2	0.2	-0.2	-0.5	-1.0	-1.1	-0.0	0.2
Medication for cholesterol	0.5	0.8	2.3	0.6	-0.7	-1.4	-1.5	-0.1	-0.8	-0.5	-1.4	-0.1	0.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.5	0.5	3.2	-0.0	0.6	1.8	0.4	-0.5	0.3	0.4	1.0	0.3	-0.0
Back pain experienced in last month	9.3	13.6	18.3	3.2	-3.5	-3.8	4.3	-2.8	-3.5	-3.9	4.2	-4.1	3.3
Mineral and other dietary supplements	0.1	0.1	0.5	-0.1	-0.4	-0.1	-0.3	-0.0	-0.3	-0.4	0.3	-0.7	0.2
Breast cancer (self-reported)	5.1	6.1	10.1	2.9	-2.7	-2.4	1.0	-3.1	-3.2	-2.8	-0.6	-1.6	2.8
Asthma (self-reported)	0.2	0.4	0.9	-0.9	-0.1	-0.3	-0.8	1.0	0.7	0.1	0.7	-0.2	-0.6
Osteoporosis (self-reported)	0.8	1.0	2.3	1.5	-0.6	-0.6	-0.0	-1.4	-1.3	-0.9	-0.7	-0.2	1.3
Osteoarthritis (self-reported)	0.8	1.0	2.2	-0.6	1.4	1.2	0.2	-0.1	0.8	1.3	-1.5	1.4	-0.1
Medication: Aspirin	1.2	1.5	3.2	-0.8	1.6	1.8	1.3	0.3	1.5	1.4	-0.7	1.4	-0.5
Medication: Gliclazide	0.1	0.1	0.3	0.0	-0.0	-0.2	0.1	0.4	0.4	-0.2	0.1	-0.1	-0.5
Illnesses of father: None of the above (group 1)	0.9	1.1	2.6	-1.4	0.8	0.1	-0.7	1.6	0.9	1.0	-0.4	1.6	-1.0
Smoking status: Current	2.5	3.9	6.7	2.1	-2.5	-2.1	0.9	-2.6	-2.0	-2.4	0.6	-1.8	1.9
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.7	1.4	3.4	-1.2	1.7	1.2	-0.0	1.1	1.6	1.9	-0.2	1.1	-0.6
Whole body water mass	0.1	0.8	1.4	-0.8	0.6	1.1	1.1	0.9	0.8	0.5	0.6	1.2	-0.9
Leg predicted mass (right)	0.1	0.7	1.4	-0.7	0.5	0.7	0.9	1.0	1.0	0.6	0.6	1.2	-0.9
Arm fat mass (left)	0.2	0.8	2.3	0.7	-0.9	-0.9	1.5	-0.2	-0.1	-0.8	1.5	-0.5	0.7
Number of self-reported non-cancer illnesses	0.1	0.1	0.7	-0.1	0.2	0.1	0.9	0.1	0.2	-0.1	0.3	-0.0	0.3
Average weekly champagne plus white wine intake	3.1	4.2	8.6	-2.9	2.0	2.3	-1.4	2.5	1.8	2.1	-0.9	1.2	-2.4
Miserableness	0.3	0.4	1.6	-0.7	0.4	0.7	0.7	0.9	0.1	0.4	1.3	-0.1	-0.5
Guilty feelings	0.7	1.1	2.1	-1.4	0.6	0.7	-0.8	1.3	0.4	0.4	-1.5	1.1	-1.3
Wears glasses or contact lenses	2.6	3.0	6.8	-1.8	1.7	1.4	-1.1	1.6	1.4	1.9	-1.7	2.6	-1.4
Ever taken oral contraceptive pill	1.9	2.1	6.0	-1.1	1.0	1.0	-1.7	0.7	1.6	1.1	-2.4	1.7	-1.3
Hearing aid user	0.3	0.3	1.6	-0.5	0.4	0.8	-1.2	-0.1	-0.1	0.4	-0.6	0.4	0.1
Mother’s age at death	0.3	0.4	1.2	-1.1	0.5	1.0	-0.1	0.8	0.1	0.3	-0.1	0.3	-0.9
Financial situation satisfaction	0.3	0.4	1.6	0.2	-0.6	-1.3	-0.4	-0.4	-0.4	-0.6	-1.0	0.1	0.4
Tinnitus: Yes, now most or all of the time	1.3	1.5	2.8	-1.2	1.6	1.7	1.6	0.7	0.9	1.2	1.4	0.5	-0.6
Commuting to job workplace: Public transport	0.2	0.2	0.5	-0.2	0.2	0.6	-0.7	0.4	0.7	0.6	0.6	0.2	-0.2
Eye problems/disorders: Glaucoma	2.7	3.2	5.9	-2.1	1.9	2.4	1.1	1.9	2.0	2.1	0.6	1.3	-1.5
Medication: Blood pressure	0.4	0.7	3.8	-0.2	0.2	0.8	1.9	-0.2	0.4	0.3	1.5	-0.5	0.2
Pain type(s) experienced in last month: Hip pain	3.3	4.2	5.8	2.0	-2.1	-1.7	1.0	-2.4	-2.4	-2.3	1.2	-2.4	2.3
Supplements: Fish oil (including cod liver oil)	0.5	0.7	2.0	-0.6	1.1	0.6	-0.3	0.8	0.8	0.9	-0.4	1.4	-0.8
High cholesterol (Self-reported)	0.6	1.1	3.7	0.8	0.5	0.4	1.9	-1.3	0.2	0.3	1.6	-0.8	1.2
Medication: Bendroflumethiazide	1.1	1.7	3.3	1.1	-1.6	-1.3	-0.0	-1.6	-1.8	-1.6	0.2	-1.1	1.4
Medication: Paracetamol	0.4	0.7	4.3	0.4	-0.4	0.5	2.1	-0.6	-0.6	-0.5	0.5	0.1	0.9
Medication: Lisinopril	0.1	0.2	0.5	0.5	0.2	0.7	0.1	-0.6	0.2	0.1	-0.2	0.4	0.4
Medication: Atorvastatin	0.9	1.1	2.6	-1.0	1.2	1.0	0.2	0.8	1.6	1.2	-0.8	1.1	-0.9
Illnesses of father: High blood pressure	0.4	0.5	1.4	0.9	-0.1	0.2	0.9	-1.2	-0.4	-0.5	0.4	-0.8	1.0
Alcohol drinker status: Never	2.3	2.8	4.6	-1.9	1.7	1.4	-1.1	1.8	1.6	1.7	-1.6	1.6	-2.1
Ever smoked	1.7	3.0	6.9	1.9	-1.9	-1.7	-0.4	-2.6	-1.6	-1.4	-2.1	-0.8	1.6
Basal metabolic rate	0.1	0.6	1.3	-0.7	0.5	0.8	1.1	0.8	0.8	0.4	0.6	1.1	-0.7
Leg fat percentage (left)	0.4	1.5	2.8	0.9	-1.2	-1.5	1.7	-0.8	-0.5	-1.1	1.5	-1.2	1.2
Arm fat-free mass (left)	0.1	0.3	2.0	-0.1	-0.2	0.3	1.4	0.1	0.1	-0.3	0.9	0.3	-0.1
Number of operations (self-reported)	1.3	1.9	4.7	-1.1	1.9	2.2	1.1	1.0	1.4	1.7	-0.3	1.4	-0.7
Average weekly beer plus cider intake	1.0	1.5	3.3	1.4	-0.9	-0.5	1.6	-0.7	-0.8	-0.9	1.8	-1.7	1.2
Irritability	0.4	0.7	1.3	0.9	-1.2	-0.5	0.5	-1.1	-0.9	-1.1	0.1	-0.8	0.7
Risk taking	4.0	5.9	10.3	-2.8	1.6	1.7	-2.8	2.9	2.7	2.3	-1.3	2.0	-3.2
Ever had prostate specific antigen (PSA) test	0.5	0.6	3.5	0.2	-0.4	0.1	-0.1	-0.9	-0.4	-0.6	-1.9	0.8	0.5
Fractured/broken bones in last 5 years	0.3	0.4	1.6	0.1	-0.7	-1.3	-0.4	0.3	-0.4	-0.6	-0.9	0.2	-0.1
Age started oral contraceptive pill	1.6	2.1	3.0	1.4	-1.6	-1.4	1.4	-1.6	-1.6	-1.7	0.8	-1.4	1.2
Diastolic blood pressure, automated reading	0.4	1.3	2.3	-1.3	1.5	1.5	-0.4	1.2	1.1	1.3	1.1	0.1	-0.9
Ever depressed for a whole week	0.6	0.8	2.3	-0.4	0.2	-0.6	-1.3	0.9	0.6	0.3	-1.5	1.1	-1.0
Unable to work because of sickness or disability	6.6	8.5	13.0	3.4	-2.9	-2.2	2.1	-3.6	-3.0	-3.2	1.9	-2.9	3.4
Commuting to job workplace: Cycle	0.1	0.2	0.5	0.2	-0.7	-0.3	0.1	0.1	-0.6	-0.3	-0.7	0.1	-0.1
Myopia	0.3	0.4	1.1	-0.0	1.0	0.2	0.6	0.1	0.9	1.0	0.3	0.3	0.2
Vascular/heart problems diagnosed by doctor	0.3	0.7	3.0	-0.4	0.2	-0.3	-1.7	1.0	0.1	0.4	-0.6	1.4	-0.5
Cholesterol lowering medication	1.2	1.7	6.2	0.9	-0.2	-0.1	2.5	-1.4	-0.2	-0.4	2.2	-1.1	1.4
Medication: Omeprazole (e.g. Zanprol)	0.1	0.2	1.2	0.1	-0.2	-0.4	1.1	-0.1	0.1	0.1	-0.5	0.2	-0.1
Pain experienced in last month	1.7	2.8	5.3	-1.6	1.7	1.0	-2.1	1.9	1.5	2.1	-0.8	1.2	-2.3
Supplements: Calcium	0.4	0.5	1.4	0.5	-0.3	-0.0	1.2	-1.0	-0.8	-0.6	-1.0	-0.0	0.5
Basal cell carcinoma (self-reported)	0.4	0.5	4.6	-0.0	-0.1	-0.2	-0.4	-0.3	0.1	0.1	-2.1	0.6	-0.2
Heart attack/myocardial infarction (self-reported)	0.1	0.2	0.8	-0.1	-0.1	0.1	0.3	-0.2	0.3	0.0	0.9	-0.7	0.1
Deep venous thrombosis (DVT) (self-reported)	0.3	0.4	1.3	-0.2	0.6	0.3	0.5	0.1	0.7	0.6	1.2	-0.7	-0.1
Heart disease (siblings)	0.6	0.7	2.2	-0.1	1.1	1.5	1.2	-0.3	0.7	1.1	0.1	0.4	0.4
Alcohol drinker status: Previous	0.1	0.2	0.8	-0.4	-0.1	-0.5	0.1	0.0	0.3	0.2	-0.9	0.2	-0.4
Pack years of smoking	0.2	0.3	1.1	-0.2	0.3	1.1	1.0	-0.3	0.5	0.2	0.7	0.1	0.0
Impedance of whole body	0.5	2.5	14.7	-0.9	0.7	-0.1	-3.8	1.3	0.5	0.7	-2.4	0.7	-0.8
Leg fat mass (left)	0.2	1.0	2.9	0.6	-1.0	-1.0	1.5	-0.4	-0.2	-0.8	1.7	-0.8	0.8
Arm predicted mass (left)	0.1	0.4	1.9	-0.4	0.1	0.6	1.4	0.3	0.4	-0.0	0.7	0.6	-0.3