Best TWAS P=2.22e-14 · Best GWAS P=1.88e-39 conditioned to 1e-25
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | SLCO1C1 | 0.14 | 0.05 | enet | 18 | 0.10 | 1.3e-12 | 2.5 | -7.6 | 2.2e-14 | -0.48 | 1.00 | 0.00 | TRUE |
| 2 | CommonMind | Brain Pre-frontal Cortex | ST8SIA1 | 0.06 | 0.04 | lasso | 3 | 0.08 | 1.1e-09 | 2.0 | -6.3 | 2.9e-10 | 0.00 | 0.00 | 1.00 | FALSE |
| 3 | GTEx | Cells EBV-transformed lymphocytes | C2CD5 | 0.36 | 0.12 | lasso | 7 | 0.17 | 4.4e-06 | -4.0 | -5.1 | 2.7e-07 | -0.02 | 0.64 | 0.08 | FALSE |
| 4 | GTEx | Cells Transformed fibroblasts | KCNJ8 | 0.28 | 0.00 | lasso | 9 | 0.00 | 1.5e-01 | -1.3 | -5.2 | 2.3e-07 | -0.04 | 0.13 | 0.04 | FALSE |
| 5 | GTEx | Esophagus Muscularis | C2CD5 | 0.14 | 0.03 | lasso | 5 | 0.06 | 1.1e-04 | -4.0 | -5.9 | 4.5e-09 | -0.01 | 0.36 | 0.12 | FALSE |
| 6 | GTEx | Heart Atrial Appendage | GOLT1B | 0.16 | 0.15 | lasso | 6 | 0.13 | 2.9e-06 | -3.0 | -5.3 | 9.3e-08 | -0.04 | 0.16 | 0.69 | FALSE |
| 7 | METSIM | Adipose | ST8SIA1 | 0.10 | 0.02 | enet | 15 | 0.05 | 6.7e-08 | 6.8 | 5.6 | 2.5e-08 | -0.01 | 0.12 | 0.88 | FALSE |
| 8 | ROSMAP | Brain Pre-frontal Cortex | ST8SIA1 | 0.08 | 0.06 | enet | 9 | 0.06 | 1.7e-08 | -7.4 | -6.9 | 6.8e-12 | 0.00 | 0.00 | 1.00 | TRUE |
| 9 | ROSMAP | Brain Pre-frontal Cortex | SLCO1C1 | 0.08 | 0.02 | blup | 573 | 0.05 | 2.5e-07 | -3.0 | -7.5 | 8.2e-14 | -0.37 | 0.51 | 0.29 | FALSE |
| 10 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | SLCO1A2 | 0.03 | 0.00 | blup | 193 | 0.02 | 3.2e-03 | -5.5 | 5.9 | 3.7e-09 | 0.05 | 0.07 | 0.10 | TRUE |