TWAS hub - SLCO1A2

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0800	0.0270	2.2e-04	0.026	0.009	0.027	0.026	0.026	3.1e-04	2.3e-02	2.8e-04	3.1e-04	3.3e-04
2	NTR	Blood	0.0184	0.0091	2.3e-02	-0.001	0.005	0.000	0.005	-0.001	9.2e-01	6.2e-03	5.0e-01	8.9e-03	5.8e-01
3	ROSMAP	Brain Pre-frontal Cortex	0.1205	0.0329	2.3e-06	0.109	0.055	0.102	0.105	0.108	7.0e-14	1.2e-07	4.3e-13	2.4e-13	1.1e-13
4	TCGA	Head and Neck Squamous Cell Carcinoma	0.0345	0.0206	5.7e-03	0.001	0.018	0.018	NA	0.006	2.2e-01	3.2e-03	3.3e-03	NA	6.7e-02
5	TCGA	Brain Lower Grade Glioma	0.0671	0.0295	5.2e-05	0.042	0.029	0.029	NA	0.022	1.3e-05	2.7e-04	2.9e-04	NA	1.5e-03
6	TCGA	Prostate Adenocarcinoma	0.0996	0.0381	7.7e-07	0.037	0.075	0.051	NA	0.048	9.0e-05	2.9e-08	4.5e-06	NA	8.5e-06

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Illnesses of mother	4.9	6.1	13.7	-3.7	0.7	-2.9	1.5	-2.0	-2.7
Average weekly beer plus cider intake	4.4	6.4	15.7	3.3	-1.8	4.0	2.5	0.4	-1.5
Illnesses of father: None of the above (group 1)	3.8	4.7	10.2	-0.6	-0.6	1.1	2.8	-3.2	-2.9
Knee pain experienced in last month	3.4	5.3	13.5	-0.6	1.2	1.1	3.7	-2.7	-2.9
Illnesses of father: Heart disease	3.3	4.6	11.3	-1.4	1.0	-2.7	-3.4	1.6	1.8
Qualifications: nursing, teaching	3.3	5.2	12.6	-3.5	1.1	-2.3	-0.4	-2.9	-1.8
Relative age voice broke	3.2	4.9	11.3	1.6	0.8	1.2	-3.4	2.9	2.2
Heel bone mineral density (BMD) T-score, automated (right)	3.1	7.1	16.1	-1.6	-1.6	-0.5	4.0	-3.6	-2.8
Eye problems/disorders: Cataract	2.8	3.2	4.8	-2.2	1.8	-2.1	-1.6	-1.6	-1.2
Ever unenthusiastic/disinterested for a whole week	2.7	3.3	6.3	0.9	-1.9	2.2	2.5	-1.2	-1.6
Illnesses of father: High blood pressure	2.7	3.3	9.0	-1.2	-0.1	-3.0	-2.1	1.7	1.4
Depression (self-reported)	2.6	3.1	7.6	2.4	1.7	2.8	0.2	-0.4	-1.5
Depression (Nagel 2018)	2.5	3.7	8.4	-0.3	0.6	1.4	2.3	-2.5	-2.9
High blood pressure (mother)	2.5	3.5	7.8	2.2	-1.9	1.3	-1.1	1.4	2.8
Happiness	2.5	3.0	9.0	2.1	0.5	3.0	1.6	-0.3	-1.3
Illnesses of siblings: Diabetes	2.5	3.0	9.0	1.2	-1.4	3.0	2.0	-0.9	-0.9
Coronary Artery Disease (CAD)	2.4	2.9	10.2	-0.4	0.7	-0.7	-3.2	1.1	2.2
Arm predicted mass (right)	2.4	12.4	37.7	2.3	0.0	3.7	6.1	-2.9	-3.1
Rheumatoid Arthritis	2.3	3.2	7.9	1.8	0.6	0.4	-2.3	2.8	1.5
Relative age of first facial hair	2.3	4.7	13.3	1.4	1.1	0.6	-3.6	2.2	2.5
Financial difficulties in last 2 years	2.3	3.1	6.9	-0.5	0.5	0.4	2.6	-2.0	-2.6
Mother’s age at death	2.3	2.9	6.9	2.5	0.4	2.6	2.0	-0.4	-0.3
Eye problems/disorders: Glaucoma	2.3	2.7	9.0	-0.9	-3.0	-0.4	1.2	-2.1	-0.6
Arm fat-free mass (left)	2.3	11.5	35.6	1.6	0.4	3.2	6.0	-3.0	-3.3
Unable to work because of sickness or disability	2.3	3.0	6.0	0.8	-0.1	2.0	1.9	-1.9	-2.4
Frequency of unenthusiasm / disinterest in last 2 weeks	2.2	3.0	7.8	-0.5	1.3	1.2	2.0	-1.6	-2.8
Ever highly irritable/argumentative for 2 days	2.2	2.7	8.7	2.9	0.5	2.2	0.5	1.1	-0.7
Family relationship satisfaction	2.2	2.7	7.2	2.1	0.5	2.7	1.1	0.7	-1.4
Supplements: Vitamin C	2.2	2.6	5.3	2.3	-1.2	2.1	0.3	1.6	1.3
Arm predicted mass (left)	2.2	11.2	34.8	1.6	0.3	3.1	5.9	-3.0	-3.3
LDL Cholesterol	2.1	3.4	14.5	1.1	-3.8	1.1	0.3	0.3	1.8
Heel bone mineral density (BMD) T-score, automated (left)	2.1	4.8	13.6	-0.9	-1.1	0.1	3.7	-2.6	-2.5
Waist circumference	2.1	7.7	22.6	1.6	-0.0	2.7	4.8	-2.2	-2.9
Weight	2.1	10.4	31.9	1.8	0.1	3.3	5.7	-2.6	-3.1
Arm fat-free mass (right)	2.1	10.9	35.0	2.0	0.0	3.3	5.9	-2.7	-2.9
Comparative body size at age 10	2.1	5.7	16.6	0.0	-0.2	1.1	3.2	-4.1	-2.5
Leg fat-free mass (right)	2.1	11.3	31.6	2.4	0.3	3.9	5.6	-2.4	-3.1
Ever had stillbirth, spontaneous miscarriage or termination	2.1	2.2	6.3	-0.5	0.7	-0.1	1.8	-1.7	-2.5
Leg predicted mass (right)	2.1	11.1	31.2	2.4	0.3	3.8	5.6	-2.4	-3.1
Leg fat mass (left)	2.1	8.3	25.3	0.9	0.2	2.1	5.0	-2.9	-3.2
Medication for hormone replacement therapy	2.0	2.2	4.4	-1.8	-0.1	-1.3	1.5	-1.4	-2.1
Leg predicted mass (left)	2.0	10.4	28.5	2.5	-0.1	3.9	5.3	-2.3	-2.7
Length of working week for main job	2.0	2.2	9.9	0.0	-0.4	-0.0	3.1	-0.8	-1.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	2.0	2.4	4.6	2.1	1.9	1.7	0.5	1.1	-1.2
Whole body fat-free mass	2.0	11.4	34.6	2.1	0.2	3.5	5.9	-2.8	-3.1
Whole body water mass	2.0	11.3	34.9	2.0	0.1	3.4	5.9	-2.8	-3.1
Medication: Atorvastatin	2.0	2.4	4.9	1.7	-0.8	1.6	-1.4	1.2	2.2
Basal metabolic rate	2.0	11.3	34.5	1.9	0.2	3.4	5.9	-2.8	-3.2
Leg fat-free mass (left)	1.9	9.8	27.0	2.4	-0.1	3.7	5.2	-2.3	-2.6
Age when periods started (menarche)	1.9	4.5	9.0	3.0	0.9	2.3	-0.6	2.7	2.1
Impedance of arm (right)	1.9	8.8	23.7	-1.6	1.8	-3.1	-4.9	3.0	2.1
Blood clot in the leg (DVT)	1.9	2.4	6.6	1.2	0.9	0.4	-1.6	2.6	1.8
Deep venous thrombosis (DVT) (self-reported)	1.9	2.4	6.1	1.0	0.8	0.3	-1.7	2.5	2.0
Impedance of whole body	1.9	9.5	24.5	-1.6	1.4	-3.5	-5.0	3.1	2.5
Impedance of leg (right)	1.8	8.5	20.9	-1.6	1.1	-3.3	-4.6	2.9	2.6
Past tobacco smoking	1.8	3.2	10.9	0.6	0.4	1.3	3.3	-1.4	-2.1
Medication: Simvastatin	1.8	2.7	6.4	-2.5	1.1	-2.5	-1.4	-0.4	0.3
Trunk fat-free mass	1.8	10.4	33.8	1.6	0.4	3.0	5.8	-2.8	-3.1
Impedance of arm (left)	1.8	8.2	21.3	-0.6	0.9	-2.6	-4.6	3.5	2.7
Trunk predicted mass	1.8	10.1	32.9	1.5	0.4	2.9	5.7	-2.8	-3.0
Arm fat mass (left)	1.8	7.2	22.4	1.0	-0.7	2.1	4.7	-2.7	-2.8
Alzheimer’s Disease (including proxy)	1.7	2.4	6.5	2.5	0.9	1.9	-0.8	1.7	0.7
Medication: Co-codamol	1.7	1.9	5.7	-0.4	-0.5	-0.3	2.4	-1.6	-1.8
Lung cancer (father)	1.7	2.0	6.0	-0.8	-1.5	-0.1	2.5	-1.7	-0.5
Leg fat mass (right)	1.7	6.5	20.2	0.8	-0.0	2.0	4.5	-2.6	-2.7
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.7	2.0	5.0	-1.0	-1.1	-0.1	1.8	-2.2	-1.2
Cholesterol lowering medication	1.7	2.5	5.8	-1.4	1.5	-1.8	-2.4	0.9	1.0
Schizophrenia vs Biploar Disorder	1.6	2.1	4.1	-0.9	1.1	-0.2	1.5	-2.0	-2.0
Heel T-Score	1.6	12.9	32.4	-2.1	-1.5	-0.4	4.7	-5.7	-4.0
Frequency of depressed mood in last 2 weeks	1.6	2.3	4.6	-0.2	-0.2	1.1	2.2	-2.0	-2.0
Pack years adult smoking proportion	1.6	2.5	7.1	2.7	-1.2	2.2	1.3	0.0	0.3
Body mass index (BMI)	1.6	7.0	18.9	1.2	-0.8	2.7	4.3	-2.7	-2.6
Glaucoma (self-reported)	1.6	1.9	4.0	-1.0	-2.0	-0.4	1.4	-1.6	-1.5
Pulse wave peak to peak time	1.6	1.9	4.0	-1.1	0.5	-0.4	1.7	-2.0	-1.7
Heart disease (mother)	1.6	1.9	5.8	0.5	0.4	-0.2	-1.8	1.3	2.4
Smoking status: Previous	1.6	2.3	6.3	-1.2	-0.2	-1.5	-2.5	0.1	2.0
Ever smoked	1.6	2.9	10.4	-1.0	0.2	-1.4	-3.2	1.4	1.4
Pack years of smoking	1.6	2.3	6.6	2.6	-1.1	2.1	1.3	-0.2	0.2
Alzheimer’s Disease (in mother)	1.5	1.7	4.8	2.2	-0.2	1.6	-1.2	1.1	0.6
Major Depression (MDD)	1.5	1.9	7.3	0.1	0.8	1.2	1.2	-0.8	-2.7
Bilateral oophorectomy (both ovaries removed)	1.5	1.7	3.2	-1.4	-1.8	-1.4	-0.7	-1.5	-0.8
Seen doctor (GP) for nerves, anxiety, tension or depression	1.5	2.3	4.6	1.8	1.6	2.1	-0.1	0.4	-1.7
High blood pressure (siblings)	1.5	2.2	6.4	1.6	2.5	1.0	0.5	1.3	1.1
Shortness of breath walking on level ground	1.5	1.8	3.6	1.9	1.7	1.8	0.6	-0.0	-1.1
Irritable Bowel Disease (IBD)	1.4	3.3	9.6	1.8	0.1	0.6	-1.8	3.1	1.8
Angina	1.4	1.9	3.9	-0.8	0.5	-1.4	-2.0	1.0	1.9
Average weekly fortified wine intake	1.4	1.6	3.3	-1.8	0.3	-1.7	-0.1	0.7	1.8
Impedance of leg (left)	1.4	6.6	13.4	-1.8	1.8	-3.4	-3.7	2.4	1.6
Alcohol usually taken with meals	1.4	2.3	5.2	-0.4	0.8	-0.9	-2.3	1.9	1.8
Hair/balding pattern: Pattern 2	1.4	1.7	4.1	0.7	-0.3	0.1	-2.0	1.6	1.8
Heart attack	1.4	1.8	5.2	0.2	0.4	-0.4	-1.8	1.3	2.3
Hip circumference	1.4	5.9	17.3	1.6	0.6	2.6	4.2	-1.6	-2.4
Hair/balding pattern: Pattern 3	1.4	2.1	6.5	-0.8	0.0	0.5	2.5	-1.6	-1.7
Pulse wave Arterial Stiffness index	1.4	1.7	4.0	0.9	-0.3	0.3	-1.6	2.0	1.5
Arm fat mass (right)	1.4	5.8	17.2	0.9	-0.5	2.0	4.2	-2.5	-2.5
Whole body fat mass	1.4	6.0	18.7	0.9	-0.0	1.8	4.3	-2.4	-2.8
Number of self-reported non-cancer illnesses	1.4	2.4	7.4	2.2	0.9	2.7	0.6	0.3	-0.7
Heart attack/myocardial infarction (self-reported)	1.4	1.8	5.9	0.3	0.4	-0.2	-1.7	1.4	2.4
Mean Putamen Volume	1.3	1.5	2.8	1.5	-1.3	1.7	-1.2	0.0	1.0
Illnesses of siblings	1.3	1.9	4.4	-1.5	-2.1	-1.8	-1.2	-0.1	0.0
Eye problems/disorders: None of the above	1.3	1.5	2.9	1.2	0.0	1.2	-0.2	1.7	1.7
Mouth/teeth dental problems: Mouth ulcers	1.3	2.1	4.2	1.8	2.0	1.8	-0.1	1.3	0.5
Ever depressed for a whole week	1.3	1.6	4.4	-0.3	-0.1	0.7	2.1	-1.6	-1.5
Primary Biliary Cirrhosis	1.2	1.7	4.5	-0.1	1.8	-0.5	-2.1	1.4	0.4
Trunk fat mass	1.2	5.0	16.5	0.9	0.1	1.7	4.1	-1.9	-2.5
Frequency of tenseness / restlessness in last 2 weeks	1.2	1.9	4.7	0.5	1.5	1.5	0.6	-1.3	-2.2
Alcohol intake versus 10 years previously	1.2	1.9	3.7	0.6	-1.9	0.7	1.7	-1.5	-1.2
Hypothyroidism/myxoedema (self-reported)	1.2	2.3	5.8	-0.9	-1.7	-0.3	1.3	-2.4	-1.5
Osteoarthritis (self-reported)	1.2	1.5	3.0	-0.3	-1.2	0.5	1.7	-1.2	-1.7
Pain type(s) experienced in last month: Hip pain	1.2	1.5	4.0	-0.8	-0.1	-0.3	2.0	-0.7	-2.0
Leg fat percentage (left)	1.2	4.5	13.3	-0.0	0.1	0.9	3.6	-2.3	-2.7
Commuting to job workplace: Cycle	1.2	1.4	3.2	1.3	-0.4	0.5	-1.8	0.1	1.8
Bipolar Disorder (2018)	1.1	1.8	3.2	0.9	-1.3	0.5	-1.7	1.3	1.8
Schizophrenia (2018)	1.1	2.2	5.3	-2.3	0.7	-1.6	-0.3	-1.7	-1.4
Crohns Disease (2017)	1.1	2.3	4.7	1.9	-1.7	1.0	-0.7	2.2	1.2
Ulcerative Colitis (UC)	1.1	2.0	4.9	1.0	1.4	0.2	-1.8	2.2	1.1
Age at First Birth	1.1	1.7	8.3	0.2	2.9	0.7	-0.5	0.9	0.1
Maternal smoking around birth	1.1	1.6	4.4	2.1	-1.2	1.7	-0.0	1.1	0.3
Multivitamins +/- minerals	1.1	1.4	2.4	1.2	-1.0	1.4	1.2	-0.3	-1.5
Hearing difficulty/problems with background noise	1.1	1.7	3.8	1.3	1.0	1.9	1.6	0.4	-1.1
Mouth/teeth dental problems	1.1	1.7	3.0	-1.4	-1.7	-1.5	0.7	-1.6	-0.2
Fluid intelligence score	1.1	2.3	3.7	-0.5	1.5	-1.3	-1.5	1.8	1.9
Health satisfaction	1.1	1.5	4.2	0.8	1.5	2.0	0.1	0.2	-1.2
Neck or shoulder pain in last month	1.1	1.6	3.9	0.2	1.0	1.0	1.5	-1.1	-2.0
Alcohol intake frequency.	1.1	2.6	8.6	1.4	-0.6	2.9	1.4	-0.8	-1.5
Number of full sisters	1.1	1.4	3.5	1.9	-0.9	1.8	-0.1	0.7	0.6
Chest pain or discomfort	1.1	1.6	3.8	0.9	1.4	2.0	1.2	-0.6	-1.2
Wears glasses or contact lenses	1.1	1.3	2.3	-1.3	-0.4	-1.5	0.4	-1.4	-1.3
HbA1C	1.0	1.1	3.4	-0.5	-0.9	0.1	-1.4	0.3	1.9
Smoking Status	1.0	2.4	4.5	1.6	-1.4	0.9	-2.1	2.0	0.8
Type 2 Diabetes (T2D) (2018)	1.0	1.8	5.2	-2.3	-1.1	-1.6	-0.7	-1.0	-0.7
Supplements: Zinc	1.0	1.1	3.6	-0.1	-0.6	0.7	1.2	-0.8	-1.9
Supplements: Glucosamine	1.0	1.2	2.1	1.2	1.0	1.2	-0.3	1.2	-1.5
Worrier / anxious feelings	1.0	1.9	4.5	1.0	2.1	0.7	-1.3	1.6	1.2
Noisy workplace	1.0	1.2	2.3	0.8	-0.8	1.4	1.5	-0.6	-1.0
Mouth/teeth dental problems: Loose teeth	1.0	1.1	3.9	-0.8	0.8	-1.1	-2.0	-0.0	-0.6
Angina (self-reported)	1.0	1.3	2.5	-0.5	0.8	-1.2	-1.6	0.9	1.5
Qualifications: NVQ or HND or HNC or equivalent	1.0	1.2	1.9	1.4	0.8	1.1	-1.3	1.3	0.4
Illness, injury, bereavement, stress in last 2 years	1.0	1.3	4.2	-1.4	0.5	-2.1	-0.5	0.5	0.9
Arm fat percentage (left)	1.0	4.0	12.4	0.6	-1.1	1.3	3.5	-2.1	-2.0
Average weekly red wine intake	1.0	1.5	5.2	-0.5	0.4	-1.0	-2.3	0.4	1.4
Friendships satisfaction	1.0	1.2	3.4	1.4	0.8	0.6	-0.7	1.8	0.6
Medication: Gliclazide	1.0	1.1	3.6	0.6	-1.9	1.3	0.7	-0.5	0.2
Alzheimer’s Disease (in father)	0.9	0.9	2.0	1.1	0.2	0.9	-0.3	1.2	1.4
Verbal and Numeric Reasoning (VNR)	0.9	2.1	7.0	0.1	1.8	-0.8	-0.6	2.6	1.2
Hearing difficulty/problems: Yes	0.9	1.4	2.9	0.7	1.1	1.2	1.5	-0.2	-1.7
Diabetes (mother)	0.9	1.1	2.8	1.1	-1.1	1.7	0.3	0.1	1.2
Current tobacco smoking	0.9	1.5	4.1	1.4	-0.2	1.2	-0.8	2.0	-0.8
Fed-up feelings	0.9	1.6	4.3	2.1	-0.4	1.9	-0.1	1.2	-0.2
Stomach or abdominal pain in last month	0.9	1.1	2.2	0.7	-0.3	1.5	1.3	-0.9	-1.1
Arm fat percentage (right)	0.9	3.5	10.4	0.4	-0.8	1.2	3.2	-2.0	-2.1
Pulse rate	0.9	1.5	6.8	0.2	2.6	0.6	1.0	0.7	-0.4
Asthma	0.9	1.8	3.8	1.6	-0.7	2.0	1.4	0.8	1.1
Prospective memory result	0.9	1.1	3.2	-0.5	0.1	-0.1	1.2	-1.3	-1.8
Exposure to tobacco smoke at home	0.9	1.1	5.6	-0.1	-0.1	0.2	2.4	-0.7	-0.4
Peak expiratory flow (PEF)	0.9	2.1	6.7	-1.5	0.0	-1.2	2.6	-1.2	0.8
Emphysema/chronic bronchitis	0.9	1.0	2.6	-0.2	0.4	0.3	1.1	-1.6	-1.4
Medication: Ibuprofen	0.9	1.1	3.1	-1.8	0.2	-1.4	-0.4	-0.2	-1.2
Medication: Allopurinol	0.9	1.2	3.1	-1.8	0.6	-0.8	1.1	-1.3	-0.6
Comparative height size at age 10	0.9	4.8	15.4	2.0	-0.5	2.4	3.9	-0.6	-1.8
Suffer from ‘nerves’	0.9	1.4	3.3	0.4	1.8	0.6	1.7	-0.3	-1.4
Medication for cholesterol	0.9	1.3	2.6	1.6	-1.3	1.6	1.0	-0.1	0.4
Asthma (self-reported)	0.9	1.8	3.6	1.5	-0.8	1.9	1.7	0.6	0.8
Smoking status: Current	0.9	1.4	3.7	1.5	-0.4	1.1	-0.7	1.9	-0.7
Ever taken oral contraceptive pill	0.9	1.0	3.2	-0.1	-0.0	-0.1	1.8	-0.7	-1.5
Ever had prostate specific antigen (PSA) test	0.9	1.0	1.8	-1.1	0.8	-1.3	0.6	-0.9	-1.1
Supplements: Calcium	0.9	1.0	2.6	0.4	-0.8	0.7	0.8	-1.2	-1.6
Intelligence (Savage-Jansen 2018)	0.8	2.4	7.1	1.6	2.7	1.1	0.5	1.7	0.2
Body Mass Index (BMI) (2010)	0.8	1.1	2.3	1.2	-0.2	1.5	1.4	-0.9	-0.5
Hypothyroidism (self reported)	0.8	1.7	4.4	-0.7	-1.2	-0.5	1.1	-1.6	-2.1
Ever had hysterectomy (womb removed)	0.8	0.9	2.2	-0.8	-1.5	-1.3	-0.4	-0.7	0.3
Townsend deprivation index at recruitment	0.8	1.1	2.1	1.2	0.9	1.5	0.8	1.1	0.1
Medication: Levothyroxine sodium	0.8	1.3	3.0	-0.7	-1.6	0.0	1.3	-1.7	-0.3
Time employed in main current job	0.8	0.9	1.5	1.1	1.1	1.2	0.2	1.2	0.3
Father’s age at death	0.8	1.1	2.7	-0.0	0.1	-0.0	1.6	-1.3	-1.4
Number of live births	0.8	1.1	3.9	-0.7	0.9	-0.4	0.2	-2.0	-1.1
Birth weight of first child	0.8	1.5	4.8	-1.0	-1.0	-0.7	1.0	-2.2	-1.0
Leg fat percentage (right)	0.8	3.0	9.1	-0.0	-0.3	0.9	3.0	-2.0	-2.0
Number of full brothers	0.8	1.0	3.5	-0.9	1.9	-0.1	-0.9	-0.4	-0.9
Number of children fathered	0.8	0.9	2.9	-1.7	0.3	-1.1	0.2	-1.0	-0.6
Commuting to job workplace: Walk	0.8	0.9	3.5	0.4	-0.3	0.9	0.6	-1.9	-0.6
Medication: Aspirin	0.8	1.1	3.3	0.1	-0.3	0.3	-1.3	1.1	1.8
High cholesterol (Self-reported)	0.8	1.4	3.3	-1.2	1.5	-1.2	-1.8	0.1	0.1
Heart disease (siblings)	0.8	0.9	3.9	0.0	2.0	0.6	-0.8	-0.3	-0.7
Triglycerides	0.7	1.1	4.1	0.4	-2.0	1.3	0.6	-0.6	0.1
BMI	0.7	3.9	9.9	-0.1	0.0	1.1	3.1	-2.9	-2.0
Systolic Blood Pressure	0.7	3.3	6.9	-0.7	-2.4	-1.1	-2.2	0.7	2.6
Ever used hormone-replacement therapy (HRT)	0.7	0.9	1.9	-0.7	1.4	-0.1	1.1	-0.8	-1.0
Severe depression (siblings)	0.7	0.8	1.6	-0.4	1.2	-0.4	-0.4	1.1	1.1
Hayfever, allergic rhinitis or eczema	0.7	1.5	6.4	-0.2	-0.2	0.3	-1.6	-0.2	2.5
Diverticular disease/diverticulitis (self-reported)	0.7	0.8	1.9	1.0	-0.2	1.0	-0.3	1.4	1.0
Medication: Atenolol	0.7	0.9	2.2	-1.5	0.1	-1.0	0.7	-1.3	-0.2
Sitting height	0.7	4.9	19.2	0.1	0.9	0.7	4.4	-2.1	-2.1
Had other major operations	0.7	0.9	1.8	-1.3	-0.5	-0.6	0.3	-1.2	-1.0
Gout (self-reported)	0.7	1.0	2.3	-1.5	0.2	-0.6	0.9	-1.3	-1.0
Birth weight	0.7	1.5	3.8	-0.9	2.0	-0.8	0.3	-1.9	-0.7
Body fat percentage	0.7	2.7	8.5	0.3	-0.1	0.9	2.9	-1.7	-2.0
Seen a psychiatrist for nerves, anxiety, tension or depression	0.7	0.9	3.1	1.8	0.0	1.4	0.1	0.5	-0.2
Age at first live birth	0.7	1.2	1.7	-1.1	1.2	-1.1	-1.0	-1.3	-0.6
Had major operations	0.7	0.9	2.3	-0.1	-1.5	0.4	-0.7	0.6	1.4
Loneliness, isolation	0.7	1.0	2.5	1.6	-0.5	1.5	-0.8	0.4	-0.4
Mineral and other dietary supplements	0.7	1.0	2.8	-0.5	-0.4	-0.4	-1.5	0.3	1.7
Medication: Bendroflumethiazide	0.7	1.1	2.4	-1.5	1.3	-1.0	-0.8	-0.7	-0.1
Alcohol drinker status: Previous	0.7	0.7	2.2	-1.5	-0.4	-0.4	0.0	-1.3	0.5
Neuroticism (2016)	0.6	0.9	2.2	1.0	0.4	1.5	0.5	0.5	-1.2
Vitamin and mineral supplements	0.6	0.8	1.6	-1.2	1.1	-1.1	-0.5	-0.4	0.4
Allergy	0.6	1.4	5.3	-1.0	0.4	-1.4	0.4	-0.2	-2.3
Pulse wave reflection index	0.6	0.7	1.6	-0.3	-0.8	-0.8	-1.3	0.8	0.9
Medication: Ventolin 100micrograms inhaler	0.6	0.8	1.9	-0.3	-1.4	0.4	1.4	-0.8	0.6
Chronic bronchitis/emphysema (mother)	0.6	0.7	1.1	0.6	-1.0	0.9	0.7	-0.8	-1.0
Exposure to tobacco smoke outside home	0.6	0.9	1.8	0.2	1.3	0.1	1.3	-1.1	-0.7
Wheeze or whistling in the chest in last year	0.6	1.1	2.4	0.5	-0.0	1.6	1.5	-0.5	-1.1
Migraine (self-reported)	0.6	0.7	2.0	-0.7	0.1	-0.7	-1.1	-1.4	0.1
Overall health rating	0.6	1.4	4.0	0.7	2.0	1.5	0.7	-0.1	-1.0
Medication: Aspirin	0.6	0.7	2.4	-0.0	-0.3	0.1	-1.1	0.8	1.6
Back pain experienced in last month	0.6	0.9	3.4	-1.0	0.2	-0.5	1.8	-0.8	-0.3
Hearing aid user	0.6	0.6	2.5	-0.8	0.6	-1.6	-0.5	-0.1	-0.4
Irritability	0.6	0.9	3.4	1.8	0.0	0.8	-0.1	0.8	1.0
Fasting Glucose	0.5	0.6	1.1	0.7	-0.4	0.9	0.6	0.6	1.1
Lupus	0.5	0.8	1.5	-0.8	1.2	-1.1	-0.7	0.7	-0.5
Ulcerative Colitis	0.5	0.7	2.1	0.0	1.5	-0.4	-0.9	0.9	0.5
Height	0.5	9.8	34.8	1.0	3.2	1.9	5.9	-1.3	-2.8
Eye problems/disorders: Diabetes related eye disease	0.5	0.5	0.9	-0.9	0.3	0.1	0.7	-1.0	-0.9
Diabetes (father)	0.5	0.6	1.3	0.9	-0.8	1.0	1.1	0.0	-0.2
Qualifications: CSEs or equivalent	0.5	0.6	1.1	1.1	-0.4	0.8	-0.9	0.9	0.4
Number of incorrect matches in round	0.5	0.9	3.0	0.4	-1.7	0.7	0.8	-0.8	-0.7
Medication: Ramipril	0.5	0.7	2.2	0.6	0.2	0.7	-0.7	1.5	0.7
Neuroticism score	0.5	1.0	2.8	1.7	0.9	1.2	0.4	0.9	0.1
Frequency of tiredness / lethargy in last 2 weeks	0.5	0.8	2.5	0.8	1.6	1.3	0.2	0.2	-0.1
Medication: Ibuprofen (e.g. Nurofen)	0.5	0.6	1.6	-1.3	-0.6	-0.8	0.2	-0.1	-1.1
Medication: Cholesterol lowering	0.5	0.8	2.1	-1.4	-0.1	-0.8	0.2	-1.4	-0.2
Medication: Lansoprazole	0.5	0.5	1.7	0.5	1.3	0.9	0.6	-0.2	-0.3
Loud music exposure frequency	0.5	0.5	2.1	-0.5	0.2	-0.2	1.4	-0.3	-0.9
Qualifications: O levels/GCSEs or equivalent	0.5	0.8	2.3	0.3	-0.2	1.5	-0.2	1.2	1.0
Reason for reducing amount of alcohol drunk: Health precaution	0.5	0.5	1.0	-0.7	0.4	-0.8	1.0	-0.8	-0.5
Medication: Omeprazole	0.5	0.6	1.3	0.1	0.8	-0.2	-1.1	1.0	0.8
Miserableness	0.5	0.9	3.4	1.1	-0.9	1.8	-0.6	0.2	0.0
Financial situation satisfaction	0.5	0.6	1.8	0.6	0.2	1.3	0.8	-0.4	-0.7
Tinnitus: Yes, now most or all of the time	0.5	0.6	1.1	0.6	0.3	0.9	1.1	0.9	0.6
Alcohol drinker status: Never	0.5	0.6	1.3	0.2	1.1	1.1	-0.1	-0.3	-1.1
Number of operations (self-reported)	0.5	0.8	1.7	-0.9	-1.0	-1.0	-1.3	0.2	0.4
Ovarian Cancer	0.4	0.5	1.5	-0.6	-0.6	-0.8	-0.0	0.0	-1.2
HDL Cholesterol	0.4	0.6	1.8	-0.3	1.3	-0.9	-0.8	0.5	-0.4
Schizophrenia (2014)	0.4	0.8	2.3	-1.5	0.4	-1.1	-0.1	-1.2	0.0
Allergy or Eczema	0.4	1.0	2.6	-1.1	0.1	-0.3	-0.9	-1.0	1.6
Chronotype (morning person)	0.4	1.0	2.4	-0.4	-1.5	-0.6	-0.9	0.4	1.5
Hand grip strength (left)	0.4	1.2	2.2	1.1	0.7	1.5	1.3	1.0	0.6
Trunk fat percentage	0.4	1.7	5.6	0.6	0.1	0.9	2.4	-1.0	-1.6
Hand grip strength (right)	0.4	1.2	2.2	1.2	0.6	1.5	0.2	1.5	0.9
Taking other prescription medications	0.4	0.6	2.6	-0.3	0.1	0.4	-0.5	-1.6	-0.8
Tinnitus: Yes, but not now, but have in the past	0.4	0.5	1.0	-0.9	0.2	-1.0	0.5	-0.8	-0.2
Serious illness, injury or assault to yourself	0.4	0.4	0.9	0.7	-0.5	-0.1	-1.0	0.8	0.5
Qualifications: A levels/AS levels or equivalent	0.4	1.0	1.7	1.0	0.4	0.9	-0.9	1.3	1.3
Serious illness, injury or assault of a close relative in last 2 years	0.4	0.4	0.7	0.5	0.9	0.9	0.8	-0.3	-0.1
Mouth/teeth dental problems: Dentures	0.4	0.7	1.9	0.9	0.9	0.7	-0.3	1.4	-0.2
Standing height	0.4	3.8	11.8	1.7	1.6	1.7	3.4	-0.3	-1.7
Hair/balding pattern: Pattern 4	0.4	1.0	2.5	-1.6	0.7	-1.5	-0.2	-1.0	-0.3
Mouth/teeth dental problems: Bleeding gums	0.4	0.5	1.1	-0.6	1.1	0.4	-0.3	-1.0	-0.4
Headache pain in last month	0.4	0.7	1.9	0.1	1.4	-0.4	0.7	-0.4	-1.3
Medication for cholesterol, blood pressure or diabetes	0.4	0.7	1.7	1.3	0.4	1.3	0.5	0.4	-0.6
Worry too long after embarrassment	0.4	0.6	1.9	1.0	1.4	0.4	0.2	0.6	0.3
Medication for pain relief, constipation, heartburn	0.4	0.7	3.2	0.1	1.8	-0.4	-0.6	-0.5	0.2
Medication: Seretide 50 evohaler	0.4	0.5	1.5	-0.2	-1.0	0.1	0.4	-0.4	1.2
Mean time to correctly identify matches	0.4	0.7	1.5	-1.2	0.8	-1.2	0.2	0.0	0.8
Handedness (chirality/laterality): Left-handed	0.4	0.5	1.4	1.2	0.2	1.0	0.1	-0.5	-0.5
Average weekly champagne plus white wine intake	0.4	0.6	1.4	0.3	-0.7	0.4	-0.1	1.1	1.2
Guilty feelings	0.4	0.6	1.7	0.5	0.9	0.9	0.2	-0.2	-1.3
Medication: Paracetamol	0.4	0.5	1.6	0.6	-0.2	0.4	-1.3	1.1	0.1
Pain experienced in last month	0.4	0.7	2.3	0.2	-0.7	-0.2	-1.5	0.3	1.1
Basal cell carcinoma (self-reported)	0.4	0.4	1.4	-0.4	-0.5	-0.5	-0.3	0.5	1.2
Bipolar Disorder or Schizophrenia	0.3	0.8	1.8	-1.3	-0.3	-1.0	-1.3	-0.5	0.0
Depressed Affect (Nagel 2018)	0.3	0.6	1.2	0.7	-0.1	1.0	0.0	-0.9	-1.1
Neuroticism (Nagel 2018)	0.3	0.6	1.1	0.8	0.8	1.1	0.3	-0.7	-0.9
Worry (Nagel 2018)	0.3	0.7	2.6	0.7	1.6	0.6	0.7	0.1	-0.3
Respiratory disease	0.3	0.7	2.8	0.1	-0.1	0.7	1.7	-0.9	-0.3
Lung FEV1/FVC ratio	0.3	1.5	3.5	-1.9	0.9	-1.3	0.2	-1.7	-0.3
Lung FVC	0.3	1.4	3.4	1.2	0.0	0.7	0.8	1.9	1.5
Neuroticism	0.3	0.7	1.0	0.9	0.9	0.8	1.0	-0.0	-0.9
Systolic blood pressure, automated reading	0.3	0.7	2.5	-0.0	-1.6	-0.5	-0.4	-0.4	1.2
Chronic bronchitis/emphysema (father)	0.3	0.3	0.7	-0.0	0.6	0.8	0.4	-0.7	0.5
Nervous feelings	0.3	0.6	1.9	0.7	0.1	0.5	-0.1	1.4	0.9
Hayfever/allergic rhinitis (self-reported)	0.3	0.4	0.9	-1.0	0.9	-0.4	-0.1	0.2	0.9
Falls in the last year	0.3	0.4	0.8	-0.5	0.8	0.5	0.1	-0.4	-0.9
Breastfed as a baby	0.3	0.4	1.6	0.1	1.3	0.7	0.6	0.1	0.0
Medication: Paracetamol	0.3	0.4	1.4	0.2	0.0	0.1	-1.0	1.2	-0.0
Forced vital capacity (FVC), Best measure	0.3	1.1	4.7	0.5	-0.7	0.9	2.2	-0.3	0.6
Medication: Blood pressure	0.3	0.5	0.8	-0.9	-0.6	-0.7	0.9	-0.8	-0.0
Pulse rate, automated reading	0.3	1.0	2.9	0.9	-0.6	1.1	0.1	1.7	0.7
Age at last live birth	0.3	0.4	1.3	-0.3	0.9	-0.3	-0.4	-1.1	-0.4
Leg pain on walking	0.3	0.3	1.0	0.4	-0.4	1.0	0.3	-0.2	-0.7
Forced expiratory volume in 1-second (FEV1), predicted	0.3	0.5	1.6	1.1	0.1	1.3	0.5	0.2	0.0
Mood swings	0.3	0.5	1.1	1.0	0.8	0.5	-0.8	-0.1	-0.7
Long-standing illness, disability or infirmity	0.3	0.5	1.5	0.7	-0.4	1.2	-0.6	-0.7	0.3
Diabetes diagnosed by doctor	0.3	0.5	1.4	-1.0	-0.0	-0.6	-1.2	-0.3	-0.5
Osteoporosis (self-reported)	0.3	0.4	1.5	0.4	0.7	1.2	0.2	-0.5	0.3
Supplements: Fish oil (including cod liver oil)	0.3	0.4	0.7	0.7	0.8	0.1	0.7	0.1	-0.8
Fractured/broken bones in last 5 years	0.3	0.4	0.7	-0.1	0.9	-0.6	-0.8	0.9	-0.1
Age started oral contraceptive pill	0.3	0.4	1.8	0.4	1.3	0.3	-0.2	-0.2	-0.3
Myopia	0.3	0.4	1.5	0.3	0.2	-0.4	-0.3	1.2	0.7
Medication: Omeprazole (e.g. Zanprol)	0.3	0.4	0.7	-0.3	0.7	-0.8	-0.8	0.4	0.4
Reaction Time	0.2	0.4	1.0	-0.4	1.0	-0.5	-0.3	0.2	0.7
Crohns Disease (2012)	0.2	0.3	1.0	0.5	-1.0	0.1	-0.1	0.8	-0.3
Blood Red Count	0.2	2.0	4.8	2.2	-0.7	1.5	0.7	2.0	0.2
Waist Hip Ratio (WHR)	0.2	0.7	3.0	-0.1	-0.2	-0.0	1.0	-0.4	-1.7
Cardiovascular Disease	0.2	0.8	2.1	-0.6	1.2	-0.4	-1.5	0.5	0.7
Number of treatments/medications taken	0.2	0.4	1.3	-1.1	-0.2	-0.7	-0.4	-0.7	-0.4
Average weekly spirits intake	0.2	0.3	0.6	0.7	0.0	0.4	0.6	-0.2	-0.7
Other serious medical condition/disability diagnosed by doctor	0.2	0.2	0.6	0.4	-0.4	0.2	-0.6	0.4	0.8
Medication: Metformin	0.2	0.3	1.0	-0.2	-0.3	0.6	-0.1	-1.0	-0.1
Forced vital capacity (FVC)	0.2	0.8	2.9	0.5	-0.4	-0.0	1.7	0.5	1.0
Qualifications: None of the above	0.2	0.3	0.5	0.6	-0.4	0.6	0.7	-0.7	-0.3
Diabetes (self-reported)	0.2	0.2	0.7	-0.8	-0.5	-0.4	-0.3	-0.1	-0.5
Forced expiratory volume in 1-second (FEV1)	0.2	0.8	2.5	-0.6	0.3	-0.9	1.6	-0.0	1.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.7	3.5	-0.2	-0.1	0.1	1.9	-0.6	0.7
Tense / ‘highly strung’	0.2	0.4	0.7	0.7	0.5	0.7	0.9	0.6	-0.1
Medication: Amlodipine	0.2	0.3	0.8	-0.4	0.6	-0.4	-0.2	-0.2	0.9
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.2	0.2	0.6	-0.7	0.6	-0.0	-0.3	-0.1	-0.6
Commuting to job workplace: Car/motor vehicle	0.2	0.3	0.5	-0.5	0.7	-0.3	-0.6	0.6	-0.1
Ever had bowel cancer screening	0.2	0.2	1.1	-0.2	1.0	-0.4	-0.1	0.1	-0.1
Breast cancer (self-reported)	0.2	0.3	0.6	0.2	-0.6	0.3	0.3	-0.8	-0.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.3	0.8	-0.7	0.5	-0.3	0.1	-0.4	0.9
Commuting to job workplace: Public transport	0.2	0.3	0.8	0.5	-0.1	0.3	0.4	-0.9	-0.5
Risk taking	0.2	0.3	0.6	-0.3	0.8	-0.6	-0.4	0.8	-0.4
Diastolic blood pressure, automated reading	0.2	0.6	2.0	0.2	-1.2	-0.1	1.4	-0.4	0.3
Bipolar Disorder (2011)	0.1	0.1	0.3	-0.2	-0.5	-0.0	-0.0	0.1	0.3
Type 2 Diabetes (T2D) (2012)	0.1	0.1	0.2	-0.2	-0.3	0.1	-0.3	0.2	-0.5
Blood Eosinophil Count	0.1	0.8	2.3	0.6	-0.5	1.0	1.5	0.6	-0.9
Blood Platelet Count	0.1	1.7	3.2	-0.9	1.7	-1.4	-1.8	-0.6	-0.8
Blood White Count	0.1	0.5	2.6	-0.1	-0.2	-0.5	1.6	0.3	-0.0
Tanning	0.1	0.7	1.7	1.0	-1.3	0.6	-0.3	0.6	0.8
Sensitivity / hurt feelings	0.1	0.2	0.4	0.5	0.6	0.5	-0.1	0.1	0.1
High blood pressure	0.1	0.2	0.7	-0.1	0.5	0.4	0.8	0.0	-0.1
Had menopause	0.1	0.2	0.9	0.2	0.1	0.2	0.9	-0.1	0.1
Pain all over the body in last month	0.1	0.1	0.2	0.5	0.1	0.2	-0.2	0.4	0.0
Qualifications: College or University degree	0.1	0.3	1.0	-0.5	0.5	-1.0	-0.4	-0.1	-0.2
Hypertension (Self-reported)	0.1	0.4	1.0	-0.5	0.7	0.4	1.0	-0.4	-0.4
Medication: Blood pressure	0.1	0.3	0.9	-0.2	0.9	0.0	-0.7	0.3	0.3
Medication: Lisinopril	0.1	0.2	0.4	-0.4	-0.6	-0.0	0.6	-0.2	0.3
Vascular/heart problems diagnosed by doctor	0.1	0.2	0.5	0.4	-0.7	-0.1	-0.6	0.3	0.0
Breast Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Hair Pigment	0.0	0.7	2.5	0.4	0.3	1.0	-1.6	-0.2	0.6

Hub : Genes

SLCO1A2

Models

Trait associations