Hub : Genes

ST8SIA1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.0640 0.0250 2.2e-03 0.045 0.027 0.067 0.048 0.077 3.5e-06 2.4e-04 1.4e-08 1.5e-06 1.1e-09
2 METSIM Adipose 0.0975 0.0310 2.8e-05 0.025 0.038 0.049 0.044 0.045 1.0e-04 1.7e-06 6.7e-08 3.1e-07 2.2e-07
3 ROSMAP Brain Pre-frontal Cortex 0.0773 0.0274 9.8e-04 0.062 0.025 0.063 0.047 0.056 2.2e-08 3.2e-04 1.7e-08 1.0e-06 8.7e-08

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
Bipolar Disorder (2018) 0.3 0.5 1.4 -0.5 -0.1 -1.2
Bipolar Disorder or Schizophrenia 0.3 0.8 1.8 0.1 -0.7 -1.3
Depressed Affect (Nagel 2018) 3.7 7.9 13.6 2.6 -3.7 1.8
Depression (Nagel 2018) 0.9 1.3 2.5 1.2 -1.6 0.4
Intelligence (Savage-Jansen 2018) 0.5 1.7 3.3 -1.8 -0.6 -1.2
Neuroticism (Nagel 2018) 4.9 11.6 17.0 4.1 -3.1 2.9
Schizophrenia (2018) 0.3 0.5 0.7 0.5 -0.9 -0.8
Schizophrenia vs Biploar Disorder 0.1 0.1 0.2 0.5 0.3 0.0
Worry (Nagel 2018) 2.3 4.9 9.5 3.1 -1.6 1.7
Alzheimer’s Disease (in mother) 0.0 0.1 0.1 -0.0 -0.4 -0.2
Alzheimer’s Disease (in father) 2.5 2.7 4.1 1.8 -2.0 0.9
Alzheimer’s Disease (including proxy) 0.3 0.4 1.0 0.5 -1.0 -0.2
Crohns Disease (2017) 0.2 0.5 0.7 -0.3 0.8 -0.8
Irritable Bowel Disease (IBD) 0.4 1.0 2.3 -1.5 0.4 -0.7
Ulcerative Colitis (UC) 1.1 2.0 5.3 -2.3 0.5 -0.7
Major Depression (MDD) 2.3 2.8 5.7 2.4 -1.3 1.0
Reaction Time 0.3 0.6 1.2 -0.1 -0.8 -1.1
Verbal and Numeric Reasoning (VNR) 0.6 1.5 3.2 -1.8 0.7 -1.0
Breast Cancer 0.0 0.0 0.0 0.0 0.0 0.0
Ovarian Cancer 0.0 0.1 0.1 -0.1 0.3 0.3
Prostate Cancer 0.0 0.0 0.0 0.0 0.0 0.0
Age at First Birth 0.3 0.4 1.1 -1.0 0.2 -0.3
Bipolar Disorder (2011) 3.6 3.5 5.8 -1.8 1.2 -2.4
Body Mass Index (BMI) (2010) 1.7 2.3 4.2 1.4 -2.0 0.9
Coronary Artery Disease (CAD) 0.2 0.2 0.4 0.7 -0.5 0.3
Crohns Disease (2012) 0.3 0.5 1.4 0.2 1.2 0.2
Mean Putamen Volume 0.4 0.4 0.6 -0.8 0.6 -0.7
Fasting Glucose 0.0 0.1 0.1 0.0 -0.2 -0.4
HbA1C 1.3 1.4 2.0 -1.3 -1.4 -0.7
HDL Cholesterol 3.4 5.7 8.3 -2.6 2.9 -1.4
LDL Cholesterol 0.1 0.1 0.3 -0.2 0.5 0.3
Lupus 0.2 0.3 0.4 -0.4 -0.5 -0.6
Neuroticism (2016) 0.8 1.2 2.5 1.6 -0.9 0.6
Primary Biliary Cirrhosis 0.5 0.7 1.5 1.2 -0.2 0.7
Rheumatoid Arthritis 0.1 0.1 0.3 -0.2 -0.5 0.4
Schizophrenia (2014) 0.6 1.3 3.4 -0.7 0.1 -1.9
Triglycerides 4.4 7.2 17.1 4.1 -1.9 0.8
Type 2 Diabetes (T2D) (2012) 1.5 1.7 2.4 -0.7 -1.5 -1.5
Ulcerative Colitis 0.4 0.5 1.0 -0.4 -0.6 1.0
Blood Eosinophil Count 0.0 0.4 0.6 -0.2 -0.7 -0.8
Blood Platelet Count 0.4 4.2 7.5 2.7 -1.4 1.7
Blood Red Count 0.1 0.9 1.6 -0.8 -0.8 -1.3
Blood White Count 0.1 0.9 2.1 -0.1 -1.5 -0.8
Heel T-Score 0.1 0.8 2.1 0.4 0.4 1.4
BMI 0.8 4.6 7.0 2.6 -2.6 0.2
Height 2.0 39.3 47.1 -6.3 5.6 -6.9
Waist Hip Ratio (WHR) 1.7 7.5 8.2 -2.9 2.6 -2.7
Systolic Blood Pressure 0.4 2.2 3.6 1.9 0.3 1.6
Smoking Status 0.8 1.9 4.0 0.6 2.0 -1.2
Allergy or Eczema 0.3 0.8 1.8 0.3 -1.3 -0.6
Cardiovascular Disease 0.2 0.8 1.0 0.9 1.0 0.7
Hypothyroidism (self reported) 0.2 0.4 1.0 0.3 1.0 0.1
Respiratory disease 1.0 2.3 3.7 1.9 -1.8 0.0
Type 2 Diabetes (T2D) (2018) 0.1 0.2 0.4 0.3 -0.6 -0.0
Lung FEV1/FVC ratio 1.2 5.9 9.8 3.1 0.8 2.7
Lung FVC 0.8 4.3 6.9 2.6 0.1 2.5
Neuroticism 3.2 7.6 10.8 3.1 -3.3 1.5
Chronotype (morning person) 1.1 2.6 5.1 -1.4 2.3 0.9
Hair Pigment 0.1 2.3 4.6 -0.0 -2.1 1.6
Tanning 0.1 0.8 1.1 -0.8 1.1 -0.8
Hand grip strength (left) 0.2 0.5 1.1 0.1 1.1 0.5
Number of treatments/medications taken 0.3 0.5 0.7 0.5 -0.9 -0.6
Average weekly spirits intake 0.1 0.1 0.3 -0.3 0.0 -0.5
Sensitivity / hurt feelings 2.0 3.5 5.2 1.8 -2.3 1.4
Frequency of depressed mood in last 2 weeks 1.8 2.5 4.8 2.2 -1.6 0.4
Hearing difficulty/problems: Yes 0.2 0.2 0.6 -0.1 0.8 -0.3
Relative age of first facial hair 2.5 5.1 5.4 2.3 -2.2 2.2
Other serious medical condition/disability diagnosed by doctor 0.7 0.9 1.6 -0.9 0.6 -1.3
Ever used hormone-replacement therapy (HRT) 0.3 0.4 0.7 -0.6 0.8 -0.4
Ever had hysterectomy (womb removed) 0.5 0.6 1.0 -0.8 1.0 -0.5
Systolic blood pressure, automated reading 1.0 2.9 4.9 2.2 -0.4 1.9
Eye problems/disorders: Diabetes related eye disease 0.3 0.4 1.1 -0.1 -1.0 -0.2
Angina 0.1 0.1 0.2 -0.2 -0.4 0.2
Medication for hormone replacement therapy 0.5 0.5 1.3 0.5 1.1 0.3
Vitamin and mineral supplements 0.0 0.0 0.1 -0.1 0.2 0.2
Supplements: Zinc 1.8 1.9 3.9 -2.0 0.1 -1.4
Medication: Co-codamol 0.3 0.4 0.7 -0.1 -0.9 0.5
Medication: Metformin 0.3 0.4 0.6 0.7 -0.5 -0.8
Diabetes (father) 0.4 0.5 1.1 0.4 -0.2 -1.1
Diabetes (mother) 0.5 0.6 1.6 0.5 -1.3 -0.2
Severe depression (siblings) 3.6 4.0 6.9 2.6 -2.2 0.7
Pack years adult smoking proportion 0.2 0.3 1.0 0.2 1.0 -0.1
Impedance of leg (right) 1.3 6.2 8.9 -3.0 2.7 -1.6
Leg fat-free mass (left) 0.1 0.6 1.6 0.4 0.1 -1.3
Trunk fat percentage 0.2 0.9 1.7 0.9 -0.0 -1.3
Hand grip strength (right) 0.4 1.0 1.5 0.3 1.2 1.2
Townsend deprivation index at recruitment 0.2 0.3 0.9 -0.3 0.9 0.1
Current tobacco smoking 1.6 2.6 4.1 -0.9 1.7 -2.0
Average weekly fortified wine intake 1.4 1.6 2.9 -1.7 1.4 -0.4
Maternal smoking around birth 1.0 1.4 2.5 0.3 1.6 1.3
Fed-up feelings 3.8 6.8 8.7 2.9 -3.0 1.8
Frequency of unenthusiasm / disinterest in last 2 weeks 0.6 0.7 1.1 1.1 -1.0 -0.1
Relative age voice broke 1.9 2.9 4.3 1.6 -1.3 2.1
Taking other prescription medications 0.8 1.3 3.0 1.7 -0.4 0.8
Age when periods started (menarche) 1.9 4.6 8.3 -2.9 2.4 0.2
Bilateral oophorectomy (both ovaries removed) 0.7 0.8 2.0 0.5 1.4 0.4
Heel bone mineral density (BMD) T-score, automated (left) 3.6 8.1 13.4 2.8 -1.7 3.7
Tinnitus: Yes, but not now, but have in the past 1.2 1.3 2.0 1.4 -0.8 1.2
Qualifications: CSEs or equivalent 2.7 3.5 8.2 1.5 -0.5 2.9
Serious illness, injury or assault to yourself 0.5 0.6 1.6 -0.3 -0.0 -1.3
High blood pressure 0.3 0.8 1.1 0.6 1.1 1.0
Hayfever, allergic rhinitis or eczema 0.2 0.4 0.7 0.8 -0.8 -0.0
Multivitamins +/- minerals 0.3 0.4 1.0 1.0 -0.3 0.2
Stomach or abdominal pain in last month 0.5 0.6 1.3 1.1 -0.1 0.8
Supplements: Glucosamine 0.2 0.2 0.4 0.4 0.4 -0.6
Diverticular disease/diverticulitis (self-reported) 0.1 0.1 0.2 0.3 -0.3 -0.5
Medication: Atenolol 0.9 1.1 1.7 1.3 0.3 1.2
Medication: Levothyroxine sodium 0.0 0.1 0.1 0.3 -0.1 0.4
Sitting height 1.3 9.1 11.8 -2.7 2.8 -3.4
Chronic bronchitis/emphysema (father) 1.7 2.0 4.7 -2.2 1.1 -0.4
High blood pressure (mother) 0.6 0.9 1.8 0.7 -1.4 0.4
Body mass index (BMI) 0.7 2.9 6.9 2.6 -1.3 -0.1
Impedance of leg (left) 1.1 5.2 6.9 -2.6 2.6 -1.4
Leg predicted mass (left) 0.1 0.6 1.5 0.4 0.0 -1.2
Trunk fat mass 0.3 1.3 2.9 0.9 0.3 -1.7
Waist circumference 0.4 1.5 3.8 0.4 0.8 -1.9
Number of incorrect matches in round 0.4 0.7 2.0 0.4 1.4 -0.4
Past tobacco smoking 1.2 2.3 4.8 -2.2 -1.4 0.4
Alcohol usually taken with meals 3.1 5.0 8.3 -2.9 1.7 -2.0
Nervous feelings 0.7 1.3 2.3 1.5 -1.0 0.9
Frequency of tenseness / restlessness in last 2 weeks 3.7 5.7 11.0 3.3 -2.2 1.2
Hearing difficulty/problems with background noise 0.2 0.3 0.6 -0.3 0.4 -0.8
Hair/balding pattern: Pattern 2 0.6 0.8 1.7 -0.8 1.3 0.1
Had menopause 0.7 0.8 1.6 -0.3 0.9 -1.3
Had other major operations 0.3 0.4 0.7 -0.9 -0.0 0.6
Forced vital capacity (FVC) 0.1 0.4 0.9 0.3 1.0 0.4
Heel bone mineral density (BMD) T-score, automated (right) 2.0 4.6 7.4 2.1 -1.3 2.7
Ever unenthusiastic/disinterested for a whole week 1.8 2.2 4.8 2.2 -0.7 1.2
Qualifications: None of the above 0.6 1.2 2.0 1.2 1.4 -0.4
Financial difficulties in last 2 years 1.9 2.6 6.2 2.5 -1.2 0.3
Mouth/teeth dental problems 0.9 1.4 2.5 -1.6 1.1 -0.7
Heart attack 0.2 0.3 0.3 0.5 -0.5 0.5
Allergy 0.9 2.0 3.6 -1.9 1.1 -1.1
Pain all over the body in last month 0.5 0.5 0.8 0.8 -0.1 -0.9
Diabetes (self-reported) 0.8 1.2 1.9 -1.4 0.3 -1.3
Hayfever/allergic rhinitis (self-reported) 0.5 0.7 1.4 1.2 0.4 -0.7
Medication: Ramipril 0.5 0.6 0.9 -1.0 1.0 0.3
Medication: Simvastatin 2.0 2.9 5.7 -1.7 0.2 -2.4
Fluid intelligence score 1.1 2.2 4.5 -2.1 0.8 -1.3
Illnesses of siblings 2.0 2.7 3.1 -1.6 1.6 -1.8
Neuroticism score 3.2 6.7 9.0 3.0 -3.0 1.5
Weight 0.3 1.4 3.3 0.9 0.4 -1.8
Impedance of arm (right) 0.2 0.9 2.2 -1.5 0.6 -0.1
Arm fat percentage (right) 0.4 1.7 4.5 2.1 -0.6 -0.6
Trunk fat-free mass 0.4 2.2 4.9 -0.6 1.1 -2.2
Hip circumference 0.2 1.0 2.5 1.6 0.2 -0.6
Time employed in main current job 0.5 0.6 1.0 0.6 -1.0 -0.6
Alcohol intake versus 10 years previously 0.2 0.3 0.8 -0.1 -0.9 0.4
Father’s age at death 0.5 0.6 1.1 1.1 -0.4 0.8
Worrier / anxious feelings 3.8 7.1 14.3 3.8 -1.5 2.2
Frequency of tiredness / lethargy in last 2 weeks 1.5 2.5 4.8 2.2 -1.3 0.9
Falls in the last year 0.7 1.0 1.5 0.5 -1.1 -1.2
Hair/balding pattern: Pattern 3 0.9 1.3 1.9 -1.2 1.4 -0.8
Number of live births 1.0 1.4 1.4 1.1 -1.2 1.2
Forced expiratory volume in 1-second (FEV1) 0.6 2.0 3.0 1.6 0.6 1.7
Pulse rate 0.2 0.4 1.1 -0.4 -0.1 1.0
Happiness 1.2 1.4 2.8 1.7 -0.9 -0.8
Noisy workplace 0.3 0.3 0.7 -0.3 0.9 0.4
Qualifications: A levels/AS levels or equivalent 0.8 1.8 3.9 -2.0 -1.1 0.5
Serious illness, injury or assault of a close relative in last 2 years 4.4 5.1 10.3 1.9 -3.2 1.1
Mouth/teeth dental problems: Dentures 0.2 0.3 0.6 -0.5 -0.8 -0.4
Asthma 0.4 0.9 1.7 1.3 -0.8 0.5
Medication: Ibuprofen (e.g. Nurofen) 1.3 1.6 4.8 0.2 -2.2 -0.0
Medication: Cholesterol lowering 0.2 0.4 1.0 -0.3 0.1 -1.0
Depression (self-reported) 1.0 1.2 2.8 1.7 -0.4 0.9
Medication: Lansoprazole 0.1 0.1 0.2 0.1 0.4 -0.4
Prospective memory result 0.9 1.1 2.1 -1.0 1.4 -0.5
Lung cancer (father) 0.3 0.4 0.8 -0.9 0.1 -0.5
Illnesses of mother 1.6 2.0 5.6 -0.6 2.4 -0.3
Forced expiratory volume in 1-second (FEV1), Best measure 0.6 1.8 3.6 1.3 0.4 1.9
Pulse wave Arterial Stiffness index 0.2 0.3 0.7 -0.9 0.1 0.2
Impedance of arm (left) 0.3 1.2 3.4 -1.8 0.5 -0.0
Arm fat mass (right) 0.3 1.3 2.4 1.5 -0.0 -1.2
Trunk predicted mass 0.4 2.2 5.0 -0.7 1.1 -2.2
Standing height 1.3 12.6 13.0 -3.5 3.5 -3.6
Length of working week for main job 1.5 1.7 4.8 -0.2 2.2 -0.4
Exposure to tobacco smoke at home 0.1 0.2 0.2 0.5 0.2 0.4
Breastfed as a baby 0.2 0.2 0.4 0.4 -0.7 0.2
Tense / ‘highly strung’ 1.8 2.9 4.4 2.1 -1.1 1.8
Seen doctor (GP) for nerves, anxiety, tension or depression 3.3 5.0 11.1 3.3 -0.5 1.9
Hair/balding pattern: Pattern 4 0.1 0.3 0.6 -0.3 -0.8 -0.6
Birth weight of first child 0.8 1.4 3.5 1.9 -0.8 0.0
Peak expiratory flow (PEF) 1.2 2.8 4.2 2.0 0.6 2.0
Pulse wave reflection index 0.2 0.2 0.3 0.5 0.5 0.4
Ever highly irritable/argumentative for 2 days 0.1 0.2 0.3 0.4 0.3 0.5
Loud music exposure frequency 2.0 2.2 4.2 2.1 0.9 1.3
Qualifications: O levels/GCSEs or equivalent 0.2 0.3 0.4 -0.6 -0.5 -0.5
Mouth/teeth dental problems: Bleeding gums 4.7 6.1 11.4 3.4 -0.6 2.5
Blood clot in the leg (DVT) 0.6 0.7 1.3 -0.9 1.1 -0.2
Medication: Paracetamol 1.7 2.8 6.9 1.0 -2.6 -0.6
Headache pain in last month 0.3 0.5 1.3 0.1 -1.2 0.4
Medication for cholesterol, blood pressure or diabetes 0.1 0.1 0.2 0.3 -0.5 0.1
Glaucoma (self-reported) 1.1 1.3 2.2 1.5 -0.3 1.3
Gout (self-reported) 0.5 0.7 1.0 -0.5 1.0 -0.8
Hypothyroidism/myxoedema (self-reported) 0.2 0.4 1.1 0.5 1.0 0.1
Medication: Amlodipine 1.2 1.7 3.0 0.9 -1.7 1.1
Medication: Ventolin 100micrograms inhaler 0.3 0.4 0.8 0.9 0.4 -0.3
Birth weight 0.4 0.8 1.2 0.7 -1.1 -0.8
Chronic bronchitis/emphysema (mother) 1.3 1.5 2.5 -1.6 0.7 -1.2
High blood pressure (siblings) 3.2 4.6 6.0 1.8 -2.1 2.5
Forced vital capacity (FVC), Best measure 0.1 0.5 0.8 0.0 0.8 0.9
Body fat percentage 0.3 1.0 1.7 1.3 0.1 -1.2
Leg fat percentage (right) 0.3 1.2 2.3 1.2 0.2 -1.5
Arm fat-free mass (right) 0.4 2.1 5.1 -0.5 1.0 -2.3
Exposure to tobacco smoke outside home 0.4 0.5 0.7 0.6 0.6 0.8
Comparative body size at age 10 0.5 1.5 4.2 2.1 0.1 -0.3
Number of full brothers 0.9 1.1 1.6 1.2 -1.3 0.5
Worry too long after embarrassment 2.8 4.7 4.9 2.1 -2.1 2.2
Seen a psychiatrist for nerves, anxiety, tension or depression 4.0 5.1 6.7 2.6 -2.4 1.7
Wheeze or whistling in the chest in last year 1.1 1.9 2.8 1.6 -1.7 -0.7
Number of children fathered 0.5 0.6 1.5 1.2 0.5 0.2
Reason for reducing amount of alcohol drunk: Health precaution 0.2 0.2 0.6 0.0 -0.2 0.8
Age at first live birth 0.6 1.1 1.7 0.2 -1.2 1.3
Pulse wave peak to peak time 0.2 0.2 0.5 0.7 0.2 -0.4
Health satisfaction 0.5 0.6 1.6 1.3 -0.5 -0.1
Shortness of breath walking on level ground 1.2 1.4 2.4 -1.2 -0.4 -1.6
Qualifications: College or University degree 0.6 2.0 3.6 -1.1 -1.9 1.1
Eye problems/disorders: None of the above 0.5 0.6 0.9 -0.9 0.1 -0.9
Mouth/teeth dental problems: Loose teeth 1.5 1.8 3.9 2.0 0.4 1.2
Emphysema/chronic bronchitis 0.4 0.5 1.0 0.5 -0.5 -1.0
Medication for pain relief, constipation, heartburn 1.7 2.8 5.6 -1.6 2.4 -0.4
Neck or shoulder pain in last month 0.3 0.4 1.0 1.0 -0.0 0.6
Medication: Blood pressure 0.3 0.5 0.8 -0.9 0.7 -0.1
Angina (self-reported) 0.1 0.1 0.1 -0.2 -0.3 0.3
Migraine (self-reported) 2.0 2.5 4.4 -2.1 0.2 -1.8
Medication: Ibuprofen 0.9 1.1 2.3 -0.6 -1.5 -0.7
Medication: Allopurinol 0.7 1.0 1.3 -0.7 1.2 -1.0
Medication: Omeprazole 3.6 4.2 7.9 2.8 -1.6 1.5
Medication: Seretide 50 evohaler 2.8 3.2 5.6 1.8 -2.4 0.9
Mean time to correctly identify matches 0.4 0.7 1.7 0.2 -0.7 -1.3
Heart disease (mother) 1.8 2.2 5.2 0.4 -2.3 1.1
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.2 0.3 0.6 0.7 -0.5 -0.1
Whole body fat mass 0.3 1.2 2.2 1.2 0.2 -1.5
Leg fat mass (right) 0.4 1.5 3.2 1.1 0.2 -1.8
Arm predicted mass (right) 0.5 2.4 5.1 -0.9 1.2 -2.3
Pulse rate, automated reading 0.7 2.2 5.8 -2.4 0.5 -0.8
Alcohol intake frequency. 0.8 1.8 4.2 0.6 -2.1 0.9
Comparative height size at age 10 0.7 4.0 5.9 -1.2 2.2 -2.4
Number of full sisters 1.3 1.5 2.2 1.4 -1.5 0.7
Suffer from ‘nerves’ 3.0 4.8 12.3 3.5 0.0 1.4
Overall health rating 1.3 2.7 7.8 2.8 -0.1 0.6
Chest pain or discomfort 1.7 2.4 5.6 1.3 -2.4 0.3
Had major operations 0.1 0.1 0.2 0.1 -0.5 -0.3
Age at last live birth 0.8 1.2 2.6 0.9 -0.4 1.6
Family relationship satisfaction 1.6 1.9 3.3 1.8 -1.4 0.8
Leg pain on walking 3.8 4.7 6.8 2.6 -2.1 1.7
Qualifications: NVQ or HND or HNC or equivalent 0.6 0.7 1.4 1.2 0.3 0.8
Commuting to job workplace: Car/motor vehicle 0.2 0.3 0.8 -0.9 0.1 -0.0
Illness, injury, bereavement, stress in last 2 years 1.0 1.2 2.1 -1.2 1.5 0.4
Medication: Aspirin 0.3 0.3 0.8 -0.9 0.5 -0.1
Supplements: Vitamin C 0.4 0.5 0.8 -0.9 0.1 -0.9
Knee pain experienced in last month 1.7 2.6 7.6 2.8 0.2 -0.3
Hypertension (Self-reported) 0.2 0.7 1.4 0.5 1.2 0.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 2.0 2.4 4.0 2.0 -1.8 0.1
Illnesses of father: Heart disease 0.7 1.0 1.3 -0.9 -1.1 1.0
Illnesses of siblings: Diabetes 0.5 0.6 1.3 0.2 -1.2 -0.6
Smoking status: Previous 1.2 1.8 4.0 2.0 1.1 0.2
Forced expiratory volume in 1-second (FEV1), predicted 0.4 0.8 2.3 -0.3 1.5 -0.2
Whole body fat-free mass 0.2 1.4 3.7 -0.2 0.7 -1.9
Leg fat-free mass (right) 0.1 0.5 0.9 0.7 -0.0 -0.9
Arm fat percentage (left) 0.4 1.5 3.8 2.0 -0.7 -0.4
Average weekly red wine intake 1.8 2.7 7.3 -0.2 2.7 0.8
Handedness (chirality/laterality): Left-handed 0.2 0.2 0.4 -0.5 -0.1 -0.7
Mood swings 6.5 11.7 14.5 3.8 -3.8 2.5
Loneliness, isolation 1.9 2.6 5.9 1.4 -2.4 0.0
Long-standing illness, disability or infirmity 0.6 1.0 1.3 1.0 0.7 1.1
Ever had bowel cancer screening 0.9 1.0 2.0 1.4 -1.0 -0.4
Diabetes diagnosed by doctor 0.6 1.0 1.8 -0.9 -0.5 -1.3
Ever had stillbirth, spontaneous miscarriage or termination 0.5 0.6 1.3 0.5 1.2 -0.1
Friendships satisfaction 0.6 0.7 1.2 1.1 -1.0 -0.1
Qualifications: nursing, teaching 1.0 1.6 4.5 0.2 -2.1 0.5
Commuting to job workplace: Walk 0.3 0.3 0.7 -0.0 0.9 0.5
Eye problems/disorders: Cataract 3.3 3.9 5.3 2.0 -1.5 2.3
Mouth/teeth dental problems: Mouth ulcers 2.3 3.6 8.6 1.4 -2.9 0.6
Medication for cholesterol 0.2 0.3 0.7 -0.4 -0.8 0.2
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.3 0.3 0.7 -0.5 -0.3 -0.8
Back pain experienced in last month 0.5 0.7 1.2 0.1 -1.1 -0.9
Mineral and other dietary supplements 0.5 0.7 1.1 0.3 -0.9 1.1
Breast cancer (self-reported) 0.3 0.4 0.8 0.9 -0.6 -0.1
Asthma (self-reported) 0.3 0.6 1.2 1.1 -0.7 -0.1
Osteoporosis (self-reported) 2.1 2.6 5.9 -0.8 1.1 -2.4
Osteoarthritis (self-reported) 0.2 0.3 0.5 0.4 0.7 0.5
Medication: Aspirin 0.1 0.1 0.3 -0.5 0.1 0.1
Medication: Gliclazide 1.5 1.7 2.7 -0.9 1.2 -1.6
Illnesses of father: None of the above (group 1) 0.5 0.6 0.9 0.8 1.0 -0.6
Smoking status: Current 1.4 2.3 3.2 -0.7 1.8 -1.8
Forced expiratory volume in 1-second (FEV1), predicted percentage 1.2 2.6 5.2 1.6 -0.2 2.3
Whole body water mass 0.2 1.2 3.4 -0.1 0.6 -1.8
Leg predicted mass (right) 0.1 0.5 0.9 0.7 -0.1 -0.9
Arm fat mass (left) 0.3 1.2 2.1 1.4 -0.1 -1.2
Number of self-reported non-cancer illnesses 0.4 0.7 1.6 1.2 -0.6 -0.1
Average weekly champagne plus white wine intake 1.0 1.4 3.8 0.5 1.9 -0.2
Miserableness 2.8 4.8 6.3 2.4 -2.5 1.5
Guilty feelings 4.7 7.1 9.4 3.1 -2.4 2.4
Wears glasses or contact lenses 0.4 0.5 1.2 0.1 -1.1 -0.5
Ever taken oral contraceptive pill 1.1 1.2 2.1 -0.6 1.5 1.1
Hearing aid user 2.2 2.5 4.5 -2.1 0.8 -1.5
Mother’s age at death 0.1 0.1 0.1 -0.3 -0.3 -0.4
Financial situation satisfaction 2.3 2.8 8.2 2.9 -0.3 0.4
Tinnitus: Yes, now most or all of the time 0.4 0.4 1.3 -1.1 -0.0 0.1
Commuting to job workplace: Public transport 1.1 1.3 2.2 1.5 -0.7 1.1
Eye problems/disorders: Glaucoma 1.4 1.6 2.2 1.5 -1.4 0.9
Medication: Blood pressure 0.2 0.3 0.5 0.6 0.7 0.3
Pain type(s) experienced in last month: Hip pain 0.5 0.6 1.5 0.5 -1.2 0.0
Supplements: Fish oil (including cod liver oil) 0.1 0.1 0.2 0.3 0.5 -0.2
High cholesterol (Self-reported) 0.5 0.9 2.0 -0.4 -1.4 -0.8
Medication: Bendroflumethiazide 1.9 2.9 3.2 -1.6 1.8 -1.7
Medication: Paracetamol 1.5 2.4 5.7 0.7 -2.4 -1.0
Medication: Lisinopril 0.1 0.1 0.3 -0.3 0.1 0.5
Medication: Atorvastatin 3.1 3.9 4.9 1.8 -1.9 2.2
Illnesses of father: High blood pressure 0.4 0.4 0.5 0.7 -0.7 -0.6
Alcohol drinker status: Never 0.5 0.6 0.9 0.7 -0.9 0.7
Ever smoked 1.3 2.2 4.8 2.2 1.1 -0.7
Basal metabolic rate 0.2 1.4 3.6 0.0 0.7 -1.9
Leg fat percentage (left) 0.4 1.3 2.8 1.7 0.0 -1.1
Arm fat-free mass (left) 0.6 3.2 6.4 -0.6 1.7 -2.5
Number of operations (self-reported) 0.8 1.2 1.9 -1.2 1.4 -0.6
Average weekly beer plus cider intake 1.6 2.3 3.9 -1.3 2.0 -1.2
Irritability 3.4 5.8 9.4 3.1 -1.6 2.3
Risk taking 0.7 1.0 2.1 1.5 -0.8 0.3
Ever had prostate specific antigen (PSA) test 0.0 0.0 0.0 0.2 -0.2 -0.2
Fractured/broken bones in last 5 years 0.5 0.6 0.9 -0.2 0.9 -1.0
Age started oral contraceptive pill 0.5 0.6 1.4 1.2 -0.0 0.7
Diastolic blood pressure, automated reading 0.8 2.5 4.5 1.6 -0.7 2.1
Ever depressed for a whole week 2.9 3.6 6.6 2.6 0.3 2.0
Unable to work because of sickness or disability 0.6 0.8 1.3 -0.6 0.9 -1.1
Commuting to job workplace: Cycle 0.1 0.1 0.3 -0.1 -0.6 0.3
Myopia 1.6 2.4 6.3 -0.2 -2.5 0.9
Vascular/heart problems diagnosed by doctor 0.3 0.8 1.2 -0.8 -0.7 -1.1
Cholesterol lowering medication 0.6 0.8 1.5 0.0 -1.2 -1.0
Medication: Omeprazole (e.g. Zanprol) 2.8 3.4 5.8 2.4 -1.8 1.1
Pain experienced in last month 0.7 1.2 3.3 -0.2 -0.4 1.8
Supplements: Calcium 1.3 1.4 2.0 -1.2 0.8 -1.4
Basal cell carcinoma (self-reported) 0.2 0.3 0.7 0.2 -0.2 0.8
Heart attack/myocardial infarction (self-reported) 0.5 0.6 0.7 0.8 -0.8 0.7
Deep venous thrombosis (DVT) (self-reported) 0.5 0.6 1.1 -0.9 1.0 -0.2
Heart disease (siblings) 0.2 0.3 0.5 -0.7 -0.6 0.0
Alcohol drinker status: Previous 0.7 0.8 1.1 0.5 1.0 1.1
Pack years of smoking 0.2 0.3 0.7 0.1 0.8 -0.3
Impedance of whole body 0.6 3.0 5.1 -2.3 1.9 -0.6
Leg fat mass (left) 0.4 1.5 2.3 1.5 0.2 -1.4
Arm predicted mass (left) 0.5 2.3 4.4 -0.3 1.6 -2.1