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chr13:20,282,946-22,173,795

Best TWAS P=6.84e-22 · Best GWAS P=5.79e-34 conditioned to 1.71e-27

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	IFT88	0.27	0.33	lasso	11	0.34	1.4e-42	7.5	7.9	3.7e-15	-0.13	1.00	0.00	FALSE
2	GTEx	Adipose Subcutaneous	IFT88	0.25	0.18	lasso	6	0.18	2.9e-14	7.6	7.6	2.9e-14	-0.13	1.00	0.00	FALSE
3	GTEx	Adrenal Gland	IFT88	0.17	0.10	lasso	4	0.10	2.2e-04	7.6	6.7	2.8e-11	-0.12	0.56	0.02	FALSE
4	GTEx	Artery Aorta	IFT88	0.25	0.23	enet	16	0.22	2.3e-12	7.6	7.6	2.8e-14	-0.12	1.00	0.00	FALSE
5	GTEx	Artery Aorta	XPO4	0.12	0.04	lasso	4	0.02	2.0e-02	4.9	-5.7	1.5e-08	0.10	0.62	0.02	FALSE
6	GTEx	Artery Coronary	IFT88	0.17	0.05	lasso	6	0.02	5.4e-02	7.6	7.0	1.8e-12	-0.14	0.24	0.04	FALSE
7	GTEx	Artery Tibial	IFT88	0.27	0.17	enet	40	0.19	1.4e-14	7.7	7.4	1.1e-13	-0.10	1.00	0.00	FALSE
8	GTEx	Brain Cerebellum	IFT88	0.29	0.24	lasso	1	0.22	3.3e-07	7.7	7.7	1.0e-14	-0.13	0.84	0.01	FALSE
9	GTEx	Cells EBV-transformed lymphocytes	CRYL1	0.27	0.00	lasso	11	0.00	3.4e-01	-5.8	-8.8	1.8e-18	0.08	0.07	0.13	FALSE
10	GTEx	Cells Transformed fibroblasts	IFT88	0.15	0.00	lasso	5	0.00	2.1e-01	3.3	7.6	2.8e-14	-0.12	0.28	0.03	FALSE
11	GTEx	Colon Transverse	IFT88	0.20	0.09	lasso	8	0.07	2.1e-04	7.6	6.0	1.4e-09	-0.09	0.33	0.03	FALSE
12	GTEx	Esophagus Gastroesophageal Junction	IFT88	0.42	0.20	lasso	8	0.23	5.7e-09	7.5	6.8	7.3e-12	-0.14	1.00	0.00	FALSE
13	GTEx	Esophagus Mucosa	IFT88	0.15	0.06	enet	26	0.10	2.9e-07	3.6	5.9	3.9e-09	-0.08	0.94	0.00	FALSE
14	GTEx	Esophagus Muscularis	IFT88	0.38	0.26	lasso	4	0.25	1.4e-15	7.7	7.8	9.2e-15	-0.13	1.00	0.00	FALSE
15	GTEx	Esophagus Muscularis	XPO4	0.10	0.00	enet	5	0.00	5.0e-01	1.1	-7.1	1.7e-12	0.10	0.15	0.10	FALSE
16	GTEx	Heart Atrial Appendage	IFT88	0.36	0.28	lasso	4	0.28	4.7e-13	7.7	7.7	1.5e-14	-0.12	1.00	0.00	FALSE
17	GTEx	Heart Left Ventricle	IFT88	0.27	0.27	lasso	7	0.26	2.3e-14	7.5	7.8	6.6e-15	-0.12	1.00	0.00	FALSE
18	GTEx	Lung	IFT88	0.18	0.14	lasso	5	0.16	1.3e-12	7.7	6.7	2.0e-11	-0.11	1.00	0.00	FALSE
19	GTEx	Nerve Tibial	IFT88	0.23	0.14	lasso	8	0.12	5.5e-09	7.8	7.2	5.8e-13	-0.12	1.00	0.00	FALSE
20	GTEx	Skin Not Sun Exposed Suprapubic	IFT88	0.12	0.08	lasso	5	0.05	1.4e-03	7.7	7.9	4.0e-15	-0.15	0.43	0.02	FALSE
21	GTEx	Skin Sun Exposed Lower leg	IFT88	0.10	0.06	lasso	4	0.06	1.7e-05	7.7	7.7	1.1e-14	-0.12	0.97	0.00	FALSE
22	GTEx	Spleen	IFT88	0.50	0.37	enet	27	0.39	4.7e-11	7.6	6.8	1.0e-11	-0.07	0.97	0.00	FALSE
23	GTEx	Testis	IFT88	0.48	0.42	lasso	7	0.46	2.4e-22	7.6	7.0	1.9e-12	-0.13	1.00	0.00	FALSE
24	METSIM	Adipose	IFT88	0.11	0.07	bslmm	543	0.07	3.9e-10	7.5	8.0	1.6e-15	-0.15	1.00	0.00	FALSE
25	METSIM	Adipose	XPO4	0.03	0.02	bslmm	544	0.01	1.1e-02	4.2	-6.0	2.0e-09	0.14	0.83	0.01	FALSE
26	YFS	Blood	IL17D	0.02	0.02	blup	482	0.01	1.8e-04	-5.8	-8.5	1.5e-17	0.13	0.72	0.01	FALSE
27	The Cancer Genome Atlas	Breast Invasive Carcinoma	IFT88	0.06	0.04	blup	86	0.03	1.4e-07	6.9	8.4	3.6e-17	-0.15	0.65	0.35	FALSE
28	The Cancer Genome Atlas	Breast Invasive Carcinoma	N6AMT2	0.02	0.02	lasso	1	0.01	4.3e-04	-5.5	5.5	4.9e-08	-0.08	0.20	0.03	FALSE
29	The Cancer Genome Atlas	Esophageal Carcinoma	IFT88	0.11	0.09	lasso	7	0.11	2.0e-04	7.5	5.6	1.8e-08	-0.08	0.02	0.89	FALSE
30	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	IFT88	0.04	0.03	blup	83	0.03	2.2e-04	7.6	9.6	6.8e-22	-0.15	0.01	0.96	TRUE
31	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	XPO4	0.03	0.01	blup	72	0.03	1.5e-04	-4.2	-6.9	5.5e-12	0.08	0.23	0.19	FALSE
32	The Cancer Genome Atlas	Brain Lower Grade Glioma	IFT88	0.11	0.10	blup	86	0.09	3.5e-10	7.8	9.6	1.4e-21	-0.14	0.01	0.99	FALSE
33	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	IFT88	0.07	0.04	lasso	8	0.06	5.5e-07	4.9	5.4	6.1e-08	-0.09	0.73	0.21	FALSE
34	The Cancer Genome Atlas	Soft Tissue Sarcoma	IFT88	0.05	0.04	blup	85	0.03	3.9e-03	3.8	6.3	2.1e-10	-0.12	0.05	0.71	FALSE
35	The Cancer Genome Atlas	Thyroid Carcinoma	IFT88	0.05	0.00	blup	85	0.02	2.1e-03	5.7	8.9	3.8e-19	-0.16	0.02	0.63	FALSE