Hub : Genes

N6AMT2

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0810	0.0270	0.00042	0.047	0.022	0.030	0.030	0.039	2.2e-06	0.00084	1.3e-04	0.00014	1.4e-05
2	GTEx	Cells EBV-transformed lymphocytes	0.1840	0.0690	0.00160	0.116	NA	0.086	NA	0.103	1.3e-04	NA	9.6e-04	NA	3.2e-04
3	GTEx	Cells Transformed fibroblasts	0.1110	0.0450	0.00300	-0.003	NA	-0.002	NA	0.000	8.0e-01	NA	5.5e-01	NA	3.0e-01
4	GTEx	Esophagus Muscularis	0.1060	0.0380	0.00110	0.109	NA	0.081	NA	0.079	3.9e-07	NA	1.2e-05	NA	1.7e-05
5	YFS	Blood	0.0264	0.0115	0.00150	0.009	0.008	0.008	0.009	0.006	5.5e-04	0.00090	9.4e-04	0.00037	3.3e-03
6	TCGA	Breast Invasive Carcinoma	0.0198	0.0113	0.00780	0.018	0.008	0.013	NA	0.015	1.0e-04	0.00620	7.4e-04	NA	4.3e-04

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Bipolar Disorder (2018)	0.1	0.2	0.7	0.1	-0.1	-0.3	-0.8	-0.4	-0.4
Bipolar Disorder or Schizophrenia	0.2	0.5	1.1	-0.3	0.8	0.9	-1.1	-0.2	0.3
Depressed Affect (Nagel 2018)	0.1	0.2	0.4	0.4	0.7	0.0	-0.5	-0.4	0.6
Depression (Nagel 2018)	0.4	0.6	1.0	-0.7	0.9	0.8	-0.7	-0.3	1.0
Intelligence (Savage-Jansen 2018)	1.7	5.1	10.2	3.2	2.6	0.8	1.0	2.0	-2.9
Neuroticism (Nagel 2018)	0.4	0.9	3.6	-0.3	0.7	0.6	-1.9	-0.7	0.8
Schizophrenia (2018)	0.4	0.8	2.0	-0.5	1.1	1.4	-0.7	0.0	0.7
Schizophrenia vs Biploar Disorder	0.3	0.3	1.1	-0.6	-0.6	0.0	0.2	0.3	1.1
Worry (Nagel 2018)	1.6	3.4	6.9	-2.0	0.9	1.1	-2.6	-2.1	1.9
Alzheimer’s Disease (in mother)	0.5	0.5	1.6	-0.6	0.7	0.5	-1.3	-0.4	0.6
Alzheimer’s Disease (in father)	0.5	0.6	1.2	0.7	-1.0	-1.1	-0.4	-0.6	-0.3
Alzheimer’s Disease (including proxy)	0.2	0.4	0.6	-0.3	-0.6	-0.5	-0.7	-0.8	0.5
Crohns Disease (2017)	0.4	1.0	2.0	-0.4	1.4	1.0	-0.4	0.6	1.4
Irritable Bowel Disease (IBD)	0.2	0.4	1.1	0.6	0.3	-0.4	0.8	1.1	-0.5
Ulcerative Colitis (UC)	0.5	1.0	1.9	0.7	-0.1	-0.8	1.4	0.9	-1.4
Major Depression (MDD)	0.6	0.7	2.4	-0.1	0.5	0.8	1.6	1.0	0.2
Reaction Time	0.4	0.8	1.8	0.5	-0.1	-1.1	0.7	1.3	-1.1
Verbal and Numeric Reasoning (VNR)	1.5	3.7	7.7	2.8	2.3	0.9	0.2	1.4	-2.5
Breast Cancer	1.6	3.7	7.9	2.6	0.1	-1.6	0.4	2.2	-2.8
Ovarian Cancer	0.9	1.3	2.2	0.7	1.2	1.0	1.5	1.2	-0.9
Prostate Cancer	0.1	0.1	0.6	-0.8	0.1	0.3	0.0	0.1	0.3
Age at First Birth	0.3	0.5	1.7	-0.1	0.5	0.9	-1.3	-0.1	-0.1
Bipolar Disorder (2011)	0.1	0.1	0.5	0.0	0.0	0.0	0.3	0.7	-0.1
Body Mass Index (BMI) (2010)	0.8	1.0	2.2	1.5	0.2	-0.6	1.0	0.9	-1.3
Coronary Artery Disease (CAD)	2.5	3.0	5.8	0.7	-2.1	-2.4	2.0	1.6	-1.0
Crohns Disease (2012)	0.1	0.2	0.3	0.2	-0.1	-0.5	-0.1	0.5	0.6
Mean Putamen Volume	0.9	1.0	1.7	0.9	-1.0	-1.3	1.1	-0.3	-1.2
Fasting Glucose	0.4	0.5	2.3	0.3	0.1	-0.1	0.7	1.5	0.2
HbA1C	0.6	0.7	2.5	-0.2	0.7	0.7	1.6	0.8	-0.1
HDL Cholesterol	0.4	0.7	3.7	0.2	-0.1	-0.2	-1.9	-0.8	-0.2
LDL Cholesterol	0.8	1.3	2.6	0.6	-0.6	-1.2	1.6	0.9	-1.4
Lupus	1.2	1.8	4.7	-0.1	-1.4	-0.9	-1.7	-2.2	0.4
Neuroticism (2016)	0.5	0.7	3.6	0.3	0.8	0.0	-1.9	0.0	0.2
Primary Biliary Cirrhosis	0.7	1.0	3.0	-0.4	-1.4	-0.8	1.7	0.3	0.4
Rheumatoid Arthritis	2.3	3.1	8.0	-2.8	-0.7	0.5	-2.0	-1.5	1.9
Schizophrenia (2014)	0.1	0.3	0.8	-0.5	0.3	0.9	-0.3	0.4	0.7
Triglycerides	0.6	0.9	3.1	0.9	0.9	-0.1	0.8	1.8	-0.7
Type 2 Diabetes (T2D) (2012)	0.2	0.3	1.1	0.0	1.0	0.5	-0.4	0.2	0.4
Ulcerative Colitis	1.0	1.4	2.1	1.2	-0.7	-0.8	1.4	1.4	-1.3
Blood Eosinophil Count	0.2	1.8	4.3	1.4	-0.9	-2.1	0.4	-0.2	-1.9
Blood Platelet Count	0.1	0.7	1.6	0.9	1.3	0.4	0.6	-0.9	-0.7
Blood Red Count	0.1	1.2	1.7	1.2	-1.0	-1.3	0.5	1.3	-1.1
Blood White Count	0.2	1.5	5.4	0.1	0.8	0.1	2.3	1.8	0.3
Heel T-Score	0.3	2.7	6.0	2.5	0.7	0.1	1.0	2.3	-1.9
BMI	0.8	4.4	9.2	0.9	-2.7	-3.0	2.5	0.7	-1.5
Height	0.9	17.0	29.8	-4.8	0.9	4.5	5.1	-1.3	5.5
Waist Hip Ratio (WHR)	0.4	1.7	4.3	1.0	-1.3	-2.1	0.5	1.3	-1.1
Systolic Blood Pressure	0.1	0.5	1.3	0.6	-0.9	-1.2	-0.3	-0.2	-0.2
Smoking Status	0.6	1.4	2.8	1.3	-1.1	-0.9	1.1	0.9	-1.7
Allergy or Eczema	0.6	1.5	4.1	0.9	-0.8	-2.0	-0.3	-0.6	-1.8
Cardiovascular Disease	1.6	5.4	10.6	2.8	0.3	-1.1	1.9	3.3	-3.0
Hypothyroidism (self reported)	0.3	0.7	2.7	0.3	1.0	0.7	1.6	0.0	-0.3
Respiratory disease	0.3	0.7	1.9	-0.6	-1.0	-1.4	0.9	0.3	-0.0
Type 2 Diabetes (T2D) (2018)	0.2	0.3	1.0	-0.2	-0.2	-0.4	-0.8	-1.0	0.2
Lung FEV1/FVC ratio	0.2	1.0	2.5	0.2	0.4	-0.5	-1.6	-0.9	-1.5
Lung FVC	0.3	1.7	4.1	1.0	2.0	1.1	-1.2	1.1	-1.0
Neuroticism	0.4	1.0	4.7	0.5	0.7	-0.3	-2.2	-0.5	0.3
Chronotype (morning person)	0.6	1.3	2.7	-1.5	-1.6	-1.0	-0.2	-0.8	1.2
Hair Pigment	0.1	2.5	5.6	-2.4	0.3	1.1	-0.2	-2.2	1.8
Tanning	0.1	1.3	3.3	-1.1	0.2	1.8	0.6	-0.8	1.6
Hand grip strength (left)	2.4	6.4	14.7	-3.1	0.6	3.2	0.3	-1.6	3.8
Number of treatments/medications taken	0.6	1.1	2.0	0.4	-1.3	-1.4	1.2	0.9	-0.3
Average weekly spirits intake	1.4	1.7	5.5	1.3	-0.0	-0.8	0.4	2.3	-1.4
Sensitivity / hurt feelings	0.6	1.0	1.5	0.8	0.8	-0.6	-1.2	1.2	-1.2
Frequency of depressed mood in last 2 weeks	0.4	0.6	1.6	-0.7	-0.1	-0.4	-0.5	-1.0	1.3
Hearing difficulty/problems: Yes	0.7	1.1	5.0	-0.4	2.2	1.0	0.0	0.6	-0.4
Relative age of first facial hair	0.5	0.9	1.9	-1.1	1.3	1.4	-0.6	-0.6	0.4
Other serious medical condition/disability diagnosed by doctor	1.3	1.7	5.7	0.1	2.4	1.5	-1.5	0.4	0.3
Ever used hormone-replacement therapy (HRT)	0.2	0.2	0.6	-0.2	0.8	0.1	-0.6	-0.3	0.1
Ever had hysterectomy (womb removed)	0.1	0.1	0.2	0.0	-0.1	-0.4	0.3	-0.4	-0.2
Systolic blood pressure, automated reading	0.2	0.6	1.3	0.1	-1.1	-1.1	-1.0	0.0	0.1
Eye problems/disorders: Diabetes related eye disease	0.6	0.7	1.7	-0.8	-0.4	0.4	-0.9	-1.3	0.6
Angina	0.2	0.3	0.5	-0.7	0.1	0.1	0.7	0.0	-0.7
Medication for hormone replacement therapy	0.4	0.4	0.9	-0.3	0.8	0.9	-0.4	0.3	0.7
Vitamin and mineral supplements	1.0	1.3	4.1	-1.0	-2.0	-0.8	1.4	-0.5	-0.3
Supplements: Zinc	0.8	0.8	2.0	0.3	1.4	0.6	-1.3	0.7	0.5
Medication: Co-codamol	0.6	0.7	2.6	0.7	-0.7	-1.6	-0.2	0.4	-0.5
Medication: Metformin	0.9	1.2	2.8	1.7	-0.2	-1.4	0.7	0.8	-1.2
Diabetes (father)	0.8	1.0	2.6	-0.9	1.6	0.7	-1.2	0.1	0.9
Diabetes (mother)	0.4	0.6	1.4	0.1	0.5	0.3	0.9	1.2	-0.9
Severe depression (siblings)	1.5	1.7	4.7	-0.7	1.2	1.3	-2.2	-1.1	0.8
Pack years adult smoking proportion	0.7	1.0	2.8	-0.3	-1.7	-1.6	0.6	0.2	0.6
Impedance of leg (right)	0.2	0.7	1.4	1.2	-0.8	-1.2	-0.7	0.7	0.1
Leg fat-free mass (left)	0.7	3.5	7.8	-2.4	-1.7	0.4	2.8	-1.4	1.6
Trunk fat percentage	2.0	8.1	18.1	1.8	-4.3	-4.2	2.4	0.4	-2.0
Hand grip strength (right)	1.6	4.4	10.5	-2.3	0.4	2.7	1.3	-1.3	3.2
Townsend deprivation index at recruitment	0.4	0.6	1.9	-1.0	-0.8	0.1	-0.0	-0.4	1.4
Current tobacco smoking	0.2	0.3	1.1	-0.1	-0.3	0.3	0.7	1.1	-0.0
Average weekly fortified wine intake	1.4	1.7	3.2	0.3	1.8	1.5	1.8	1.0	0.7
Maternal smoking around birth	1.0	1.5	3.2	-1.5	-0.1	0.7	-1.8	-1.2	1.3
Fed-up feelings	0.2	0.3	0.6	-0.2	0.8	0.3	-0.5	-0.7	0.8
Frequency of unenthusiasm / disinterest in last 2 weeks	0.6	0.8	2.8	-0.4	0.2	0.4	-1.7	-0.8	1.0
Relative age voice broke	2.3	3.5	10.2	-1.7	0.9	1.5	-3.2	-1.1	1.9
Taking other prescription medications	0.3	0.5	2.1	0.2	-0.3	-0.5	1.5	0.0	-0.7
Age when periods started (menarche)	1.0	2.4	6.4	-1.2	-2.5	-1.1	-0.1	-1.5	1.7
Bilateral oophorectomy (both ovaries removed)	0.9	1.1	3.6	-0.1	1.6	1.9	0.5	-0.3	0.1
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.2	0.9	-0.0	-1.0	0.2	0.5	0.3	0.2
Tinnitus: Yes, but not now, but have in the past	0.2	0.2	0.6	-0.2	0.7	0.5	0.8	0.1	0.3
Qualifications: CSEs or equivalent	0.1	0.2	0.4	0.2	-0.2	-0.5	0.6	-0.4	-0.3
Serious illness, injury or assault to yourself	0.4	0.4	1.9	0.0	-0.6	-1.4	-0.5	-0.4	0.2
High blood pressure	0.9	2.5	5.9	1.7	-0.0	-0.6	0.4	2.4	-2.4
Hayfever, allergic rhinitis or eczema	1.6	3.4	7.7	2.1	-1.3	-2.8	0.7	0.0	-2.5
Multivitamins +/- minerals	0.8	1.0	3.2	0.8	1.8	1.2	-0.6	0.4	0.7
Stomach or abdominal pain in last month	0.9	1.2	3.0	-0.2	1.7	1.2	-1.3	0.1	0.9
Supplements: Glucosamine	0.4	0.6	1.9	0.8	0.3	0.0	1.4	0.7	-0.6
Diverticular disease/diverticulitis (self-reported)	0.2	0.3	0.6	0.5	0.3	0.1	0.1	0.7	-0.8
Medication: Atenolol	0.4	0.4	2.0	0.4	0.5	0.4	-1.4	-0.1	-0.0
Medication: Levothyroxine sodium	0.3	0.4	1.0	-0.3	1.0	1.0	0.6	0.4	0.2
Sitting height	0.7	4.8	15.1	-2.1	-0.1	1.9	3.9	-0.2	2.4
Chronic bronchitis/emphysema (father)	3.9	4.6	8.4	2.9	-1.4	-2.4	2.3	1.0	-2.3
High blood pressure (mother)	0.9	1.2	3.5	1.7	0.7	-0.2	-0.3	0.6	-1.9
Body mass index (BMI)	0.8	3.2	7.2	0.7	-2.7	-2.5	1.6	-0.2	-1.7
Impedance of leg (left)	0.1	0.4	0.6	0.6	-0.7	-0.8	-0.7	0.4	0.3
Leg predicted mass (left)	0.7	3.7	7.8	-2.5	-1.6	0.4	2.8	-1.5	1.7
Trunk fat mass	1.3	5.7	15.0	0.5	-3.9	-3.2	2.8	-0.2	-0.9
Waist circumference	0.9	3.3	6.6	0.2	-2.6	-2.3	2.5	0.5	-1.2
Number of incorrect matches in round	0.4	0.7	1.5	-0.4	-0.7	-1.0	-1.2	-0.2	1.1
Past tobacco smoking	0.6	1.1	4.7	-1.4	-0.4	0.2	0.2	-0.3	2.2
Alcohol usually taken with meals	0.5	0.7	1.4	-1.2	0.6	0.9	-0.2	-0.7	1.2
Nervous feelings	0.5	1.0	2.9	-0.3	-1.4	-1.7	-0.5	-0.7	-0.3
Frequency of tenseness / restlessness in last 2 weeks	1.0	1.5	4.0	-1.1	0.3	0.6	-0.7	-1.7	2.0
Hearing difficulty/problems with background noise	0.8	1.3	2.8	1.0	-0.0	-1.7	1.1	0.9	-1.4
Hair/balding pattern: Pattern 2	0.2	0.2	0.8	0.3	0.5	0.9	0.1	0.1	0.5
Had menopause	1.0	1.3	2.5	-1.6	-1.0	-0.0	-1.2	-1.1	1.3
Had other major operations	0.3	0.3	1.4	-0.6	0.2	0.1	-0.4	-0.0	1.2
Forced vital capacity (FVC)	0.6	2.2	5.4	-1.6	1.1	2.3	0.9	-0.4	1.7
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.3	1.1	0.3	-1.0	-0.5	0.6	-0.2	-0.0
Ever unenthusiastic/disinterested for a whole week	1.7	2.0	3.4	1.8	-1.0	-1.6	1.3	1.2	-1.5
Qualifications: None of the above	1.6	3.4	6.8	-2.5	-1.2	0.2	-1.4	-2.6	2.0
Financial difficulties in last 2 years	0.4	0.5	1.3	-0.3	-1.1	-0.7	0.0	-0.9	0.4
Mouth/teeth dental problems	1.0	1.6	4.1	0.8	-2.0	-1.7	1.2	0.6	-0.3
Heart attack	1.2	1.5	4.3	-1.0	1.8	2.1	-0.0	-0.1	0.3
Allergy	0.6	1.3	3.5	-0.9	1.0	1.9	-0.6	0.2	1.5
Pain all over the body in last month	1.1	1.2	2.4	-1.6	0.5	1.4	-0.4	-0.9	1.2
Diabetes (self-reported)	1.1	1.7	3.1	1.1	-1.3	-1.7	0.8	0.4	-1.8
Hayfever/allergic rhinitis (self-reported)	2.3	3.0	8.7	0.8	-3.0	-2.7	0.6	-0.2	-1.0
Medication: Ramipril	1.7	2.2	7.0	-0.3	2.6	2.4	0.1	-0.1	0.4
Medication: Simvastatin	1.4	2.0	3.9	0.9	-1.8	-2.0	1.3	0.7	-1.4
Fluid intelligence score	1.3	2.7	6.4	2.5	0.6	-0.6	1.9	1.4	-1.9
Illnesses of siblings	0.2	0.3	0.7	0.3	0.3	-0.3	0.8	0.4	-0.8
Neuroticism score	0.4	0.8	3.0	-0.3	1.0	0.3	-1.7	-0.4	0.8
Weight	0.7	3.6	8.4	-1.4	-2.9	-1.1	2.9	-1.2	0.6
Impedance of arm (right)	0.7	3.5	6.9	2.6	-1.4	-2.6	0.9	1.7	-1.3
Arm fat percentage (right)	2.0	7.9	16.7	2.2	-3.6	-4.1	2.1	0.6	-2.9
Trunk fat-free mass	1.4	7.8	17.5	-4.2	-0.3	2.7	2.1	-2.5	3.4
Hip circumference	0.6	2.5	6.3	-0.6	-2.5	-1.7	2.3	-0.8	-0.1
Time employed in main current job	0.6	0.7	1.4	-1.1	0.8	0.4	-0.6	-0.6	1.2
Alcohol intake versus 10 years previously	0.3	0.4	0.9	-0.3	-0.8	-0.7	-0.4	-0.9	0.2
Father’s age at death	0.5	0.7	1.4	-0.9	0.7	1.2	0.6	-1.0	0.5
Worrier / anxious feelings	0.8	1.6	5.2	-1.4	0.2	0.4	-2.3	-0.8	1.3
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.4	1.5	-0.6	-0.0	-0.4	1.2	-0.7	0.2
Falls in the last year	0.3	0.5	1.6	-0.3	0.7	0.2	-1.3	-0.6	-0.3
Hair/balding pattern: Pattern 3	1.2	1.7	2.9	-1.2	0.9	1.4	-1.7	-1.7	0.6
Number of live births	0.2	0.2	0.7	-0.1	-0.0	0.1	-0.8	-0.3	0.8
Forced expiratory volume in 1-second (FEV1)	0.4	1.3	3.0	-1.6	0.7	1.7	0.4	-0.8	1.0
Pulse rate	2.5	4.3	9.7	3.1	0.9	-0.6	2.0	2.5	-2.2
Happiness	0.8	1.0	2.9	-0.1	1.7	1.2	-1.0	-0.5	0.5
Noisy workplace	0.8	1.0	3.4	-0.5	0.9	1.8	0.5	-0.1	1.2
Qualifications: A levels/AS levels or equivalent	1.8	4.0	5.9	2.2	1.9	0.5	2.4	2.3	-2.0
Serious illness, injury or assault of a close relative in last 2 years	0.3	0.4	1.0	0.0	1.0	0.6	-0.6	-0.6	0.5
Mouth/teeth dental problems: Dentures	0.1	0.2	1.0	-0.6	-0.2	0.1	-1.0	-0.1	0.2
Asthma	0.3	0.6	1.2	0.2	-0.5	-1.1	0.9	0.8	-0.7
Medication: Ibuprofen (e.g. Nurofen)	1.2	1.6	5.2	-2.3	-0.6	1.1	1.1	-0.4	1.2
Medication: Cholesterol lowering	0.2	0.3	0.7	0.4	-0.1	-0.6	0.6	0.6	-0.8
Depression (self-reported)	1.4	1.7	3.9	1.4	0.1	-0.8	1.6	1.1	-2.0
Medication: Lansoprazole	0.3	0.3	1.0	-0.6	0.1	-0.0	-1.0	-0.5	0.6
Prospective memory result	0.1	0.1	0.3	0.1	-0.2	-0.3	0.0	0.5	-0.3
Lung cancer (father)	0.9	1.1	3.0	0.4	-1.7	-1.5	-0.1	0.5	-0.9
Illnesses of mother	0.4	0.5	1.5	0.6	-0.6	-1.2	0.8	0.4	-0.2
Forced expiratory volume in 1-second (FEV1), Best measure	0.4	1.1	1.9	-1.4	0.7	1.4	0.9	-1.1	0.7
Pulse wave Arterial Stiffness index	0.5	0.6	1.1	-0.5	0.9	1.1	0.3	-1.0	0.4
Impedance of arm (left)	0.5	2.5	4.9	2.2	-1.0	-2.1	0.9	1.7	-1.1
Arm fat mass (right)	1.1	4.4	11.7	0.3	-3.4	-2.7	2.4	-0.5	-1.2
Trunk predicted mass	1.4	8.2	18.2	-4.3	-0.3	2.8	2.1	-2.6	3.5
Standing height	1.1	11.2	23.5	-4.5	-0.7	2.7	3.3	-2.2	4.9
Length of working week for main job	0.4	0.5	1.2	-1.1	-0.8	-0.4	-0.3	-0.2	0.7
Exposure to tobacco smoke at home	0.4	0.4	1.1	-0.1	-0.9	-1.1	0.1	-0.5	-0.5
Breastfed as a baby	0.3	0.3	0.7	0.1	0.8	0.4	0.6	0.8	0.5
Tense / ‘highly strung’	1.1	1.9	5.3	-1.3	1.0	0.7	-2.3	-0.9	1.4
Seen doctor (GP) for nerves, anxiety, tension or depression	0.9	1.4	2.8	1.7	0.8	-0.3	0.7	1.6	-1.4
Hair/balding pattern: Pattern 4	0.2	0.5	1.2	-0.1	-1.1	-0.8	1.1	-0.1	0.5
Birth weight of first child	0.4	0.7	1.8	-1.0	-0.8	0.5	0.3	-0.7	1.3
Peak expiratory flow (PEF)	0.3	0.7	2.0	-1.1	-0.7	0.3	1.4	-0.4	0.7
Pulse wave reflection index	1.3	1.6	3.1	-1.3	1.1	1.8	-0.7	-0.8	1.5
Ever highly irritable/argumentative for 2 days	0.8	0.9	4.0	-0.2	-2.0	-1.0	0.4	-0.6	0.2
Loud music exposure frequency	0.2	0.3	0.5	-0.1	0.7	0.7	-0.5	0.6	0.1
Qualifications: O levels/GCSEs or equivalent	0.9	1.4	2.7	0.9	1.7	0.7	0.5	1.6	-1.3
Mouth/teeth dental problems: Bleeding gums	1.7	2.2	7.9	0.5	2.8	1.9	-0.9	-0.2	-0.3
Blood clot in the leg (DVT)	2.0	2.5	5.1	-2.2	-1.3	0.1	-0.3	-2.3	1.8
Medication: Paracetamol	0.8	1.4	3.4	-1.8	-0.3	0.6	-0.5	-1.1	1.7
Headache pain in last month	0.4	0.6	2.3	-0.8	-0.4	-0.1	0.4	-0.7	1.5
Medication for cholesterol, blood pressure or diabetes	1.1	1.8	4.2	-1.2	0.3	1.3	-0.8	-1.6	2.0
Glaucoma (self-reported)	0.5	0.6	1.9	-0.9	-0.4	-0.2	-1.4	-0.8	0.4
Gout (self-reported)	0.5	0.7	2.9	0.0	-1.7	-0.9	0.7	-0.5	-0.1
Hypothyroidism/myxoedema (self-reported)	0.1	0.2	0.8	0.1	0.3	0.3	0.9	-0.2	-0.1
Medication: Amlodipine	0.3	0.4	2.2	0.3	0.3	-0.4	-0.3	-0.0	-1.5
Medication: Ventolin 100micrograms inhaler	1.2	1.6	3.0	1.7	-0.9	-1.7	1.1	0.2	-1.1
Birth weight	0.5	1.2	3.3	-0.1	0.1	0.8	-1.5	-1.0	1.8
Chronic bronchitis/emphysema (mother)	0.5	0.5	1.2	-1.1	0.8	1.0	-0.5	-0.5	0.1
High blood pressure (siblings)	0.6	0.8	1.8	0.1	1.3	1.3	-0.7	0.7	0.6
Forced vital capacity (FVC), Best measure	0.4	1.4	2.6	-1.5	0.1	1.3	1.6	-0.5	1.2
Body fat percentage	1.8	7.1	16.1	1.8	-3.7	-4.0	2.0	0.5	-2.2
Leg fat percentage (right)	1.6	5.7	12.8	1.9	-3.4	-3.6	1.6	0.4	-2.1
Arm fat-free mass (right)	1.5	7.7	19.8	-4.5	-0.6	2.4	1.7	-2.5	3.4
Exposure to tobacco smoke outside home	0.3	0.4	1.1	-0.9	-0.2	0.5	-0.5	-1.1	0.2
Comparative body size at age 10	1.9	5.2	10.2	3.2	1.2	-0.8	1.6	2.8	-3.0
Number of full brothers	0.3	0.3	0.8	-0.9	-0.2	0.1	0.5	-0.5	0.8
Worry too long after embarrassment	0.5	0.9	2.3	1.3	0.6	-0.3	-0.2	1.0	-1.5
Seen a psychiatrist for nerves, anxiety, tension or depression	1.2	1.5	4.3	1.5	1.1	-0.1	1.1	0.6	-2.1
Wheeze or whistling in the chest in last year	0.2	0.3	0.7	0.0	-0.3	-0.3	0.8	0.8	-0.4
Number of children fathered	0.4	0.4	1.3	-0.0	-1.1	-0.9	-0.5	-0.2	0.1
Reason for reducing amount of alcohol drunk: Health precaution	3.3	3.9	9.9	2.8	-0.4	-1.7	0.8	1.3	-3.1
Age at first live birth	0.6	1.0	1.9	-0.9	1.0	1.1	-0.6	-1.4	0.9
Pulse wave peak to peak time	0.4	0.4	0.9	0.2	-0.9	-1.0	-0.2	0.8	-0.0
Health satisfaction	0.0	0.1	0.2	0.1	0.2	0.1	-0.4	-0.1	-0.4
Shortness of breath walking on level ground	0.6	0.7	1.9	0.7	-1.4	-0.8	0.3	-0.5	-1.0
Qualifications: College or University degree	0.6	1.8	4.7	1.2	2.2	1.0	1.2	1.4	-0.8
Eye problems/disorders: None of the above	2.0	2.3	5.8	1.8	-0.1	-0.8	1.2	1.7	-2.4
Mouth/teeth dental problems: Loose teeth	0.6	0.7	1.9	-0.9	0.5	0.9	-0.2	-1.4	0.7
Emphysema/chronic bronchitis	0.6	0.6	2.0	-0.6	1.4	1.0	-0.3	0.6	0.2
Medication for pain relief, constipation, heartburn	0.5	0.9	2.3	1.5	0.1	-0.8	-0.5	0.8	-1.2
Neck or shoulder pain in last month	0.4	0.6	2.2	-1.0	0.0	0.6	-0.1	-0.4	1.5
Medication: Blood pressure	1.0	1.7	3.7	1.4	-0.2	-1.0	1.0	1.6	-1.9
Angina (self-reported)	0.2	0.3	0.7	-0.8	0.0	0.1	0.8	-0.2	-0.4
Migraine (self-reported)	2.2	2.8	10.9	1.0	0.7	0.5	1.9	3.3	-0.6
Medication: Ibuprofen	3.1	3.7	12.1	-3.5	-0.7	1.6	0.6	-0.9	2.4
Medication: Allopurinol	1.3	1.8	3.8	1.2	-0.9	-0.9	2.0	1.4	-1.3
Medication: Omeprazole	1.8	2.1	4.0	-2.0	0.3	1.4	-0.9	-1.4	2.0
Medication: Seretide 50 evohaler	1.1	1.3	2.0	1.2	-1.4	-1.3	0.6	0.9	-1.1
Mean time to correctly identify matches	0.5	1.0	2.1	0.9	0.9	-0.4	0.7	1.4	-1.4
Heart disease (mother)	1.4	1.7	3.4	-0.7	1.4	1.8	-1.7	-0.9	0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	5.0	6.0	12.1	3.1	0.0	-1.7	1.4	3.1	-3.5
Whole body fat mass	1.0	4.2	11.6	0.0	-3.4	-2.6	2.5	-0.6	-0.7
Leg fat mass (right)	1.0	3.9	11.6	-0.0	-3.4	-2.6	2.1	-0.5	-0.7
Arm predicted mass (right)	1.3	6.5	15.8	-4.0	-0.5	2.2	1.8	-2.2	3.1
Pulse rate, automated reading	1.5	5.0	7.3	2.5	-1.1	-2.7	2.5	2.3	-2.0
Alcohol intake frequency.	1.2	2.8	5.8	-1.8	-2.4	-1.1	-0.0	-2.0	1.5
Comparative height size at age 10	0.7	3.9	9.2	-2.7	-0.8	1.4	2.2	-0.6	3.0
Number of full sisters	0.5	0.7	1.7	-1.3	-0.9	-0.2	-0.6	-0.1	1.1
Suffer from ‘nerves’	2.0	3.1	7.5	-1.0	1.6	1.5	-2.7	-2.2	0.9
Overall health rating	0.5	1.0	2.0	-0.7	-1.3	-1.4	-0.9	-1.0	0.0
Chest pain or discomfort	1.1	1.6	3.4	-1.4	1.6	1.8	0.2	0.2	1.2
Had major operations	0.8	0.9	3.6	0.1	1.2	0.3	-1.9	-0.2	-0.6
Age at last live birth	1.0	1.5	2.3	-1.4	0.6	1.4	-0.7	-1.4	1.5
Family relationship satisfaction	0.7	0.8	1.7	-0.3	1.3	1.2	-0.8	-1.0	0.2
Leg pain on walking	0.1	0.1	0.5	0.2	0.7	0.5	0.2	0.1	-0.0
Qualifications: NVQ or HND or HNC or equivalent	1.1	1.3	3.3	-1.4	-1.0	0.1	-0.7	-1.1	1.8
Commuting to job workplace: Car/motor vehicle	0.5	0.6	1.3	0.3	-0.5	-0.8	-1.1	-0.7	-0.9
Illness, injury, bereavement, stress in last 2 years	0.4	0.5	2.2	0.4	-0.0	0.4	1.5	0.4	-0.1
Medication: Aspirin	0.6	0.8	2.7	0.6	-0.6	-0.6	1.6	0.8	-0.8
Supplements: Vitamin C	0.2	0.3	1.3	-0.4	-0.0	0.0	-1.1	-0.3	0.2
Knee pain experienced in last month	0.3	0.4	0.8	0.1	-0.9	-0.7	0.8	0.5	-0.5
Hypertension (Self-reported)	0.9	2.4	5.4	1.8	0.2	-0.5	0.6	2.3	-2.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.8	2.1	4.7	-0.1	2.0	2.2	-1.3	-1.0	1.0
Illnesses of father: Heart disease	0.1	0.2	0.6	0.5	0.4	0.1	0.0	-0.2	-0.8
Illnesses of siblings: Diabetes	0.6	0.7	1.6	-0.7	-1.3	-0.8	0.5	-1.0	-0.2
Smoking status: Previous	1.1	1.6	6.2	1.7	0.2	-0.6	-0.4	0.4	-2.5
Forced expiratory volume in 1-second (FEV1), predicted	1.0	2.0	4.8	-2.1	-0.9	0.5	2.2	-0.2	1.5
Whole body fat-free mass	1.1	6.3	14.3	-3.8	-0.9	1.9	2.4	-2.3	2.9
Leg fat-free mass (right)	0.8	4.1	8.4	-2.9	-1.4	0.9	2.7	-1.7	1.9
Arm fat percentage (left)	1.6	6.5	13.5	1.8	-3.3	-3.7	2.2	0.5	-2.5
Average weekly red wine intake	0.4	0.6	1.9	0.6	-0.1	-1.4	-0.4	-0.1	-1.1
Handedness (chirality/laterality): Left-handed	0.4	0.5	2.8	0.1	-0.1	-0.1	-1.7	-0.5	-0.3
Mood swings	0.2	0.3	0.8	-0.5	0.0	-0.3	-0.3	-0.8	0.9
Loneliness, isolation	0.9	1.2	2.9	1.7	0.3	-0.7	0.6	1.1	-1.5
Long-standing illness, disability or infirmity	0.4	0.7	0.9	-0.2	-0.6	-1.0	-0.9	-1.0	-0.9
Ever had bowel cancer screening	0.6	0.7	2.2	1.1	1.5	0.5	-0.2	0.0	-0.7
Diabetes diagnosed by doctor	0.6	1.1	2.4	0.7	-1.3	-1.5	0.5	-0.2	-1.3
Ever had stillbirth, spontaneous miscarriage or termination	0.9	1.0	3.2	-0.3	1.2	0.8	-1.8	-0.1	0.8
Friendships satisfaction	0.3	0.4	1.1	1.0	0.7	0.6	0.2	-0.4	-0.5
Qualifications: nursing, teaching	1.0	1.5	6.5	-0.0	2.6	1.3	-0.6	0.6	-0.5
Commuting to job workplace: Walk	1.1	1.2	2.7	1.1	1.6	-0.1	0.8	1.7	-0.2
Eye problems/disorders: Cataract	1.1	1.3	4.4	-1.3	0.7	0.9	-0.4	-0.3	2.1
Mouth/teeth dental problems: Mouth ulcers	1.6	2.6	5.5	-1.1	2.3	2.2	-1.7	-0.8	0.7
Medication for cholesterol	0.4	0.6	1.1	-0.7	1.1	0.8	-0.8	-0.8	0.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.1	1.2	2.3	-1.0	1.5	1.2	-0.6	-1.3	0.8
Back pain experienced in last month	0.8	1.1	2.6	-1.0	0.8	0.8	-0.3	-1.6	1.2
Mineral and other dietary supplements	0.4	0.6	1.3	-0.3	-1.2	-0.7	0.6	-0.7	-0.7
Breast cancer (self-reported)	0.6	0.7	1.7	-0.8	-0.4	-0.1	-1.0	-1.3	0.9
Asthma (self-reported)	0.3	0.6	1.1	0.1	-0.3	-0.9	1.0	1.0	-0.6
Osteoporosis (self-reported)	1.2	1.5	5.2	-0.0	0.5	0.3	-2.3	-1.2	1.4
Osteoarthritis (self-reported)	0.2	0.2	0.4	-0.6	-0.6	0.4	0.5	0.2	0.1
Medication: Aspirin	0.6	0.8	3.3	0.7	-0.4	-0.3	1.8	0.8	-0.6
Medication: Gliclazide	1.0	1.1	2.7	-0.8	0.1	0.3	-1.6	-1.2	1.4
Illnesses of father: None of the above (group 1)	0.5	0.6	1.1	-1.0	-0.7	0.5	0.6	0.3	1.0
Smoking status: Current	0.2	0.3	0.6	-0.3	0.2	0.6	0.7	0.8	0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.1	0.3	1.1	-0.3	-0.4	-0.1	-1.1	-0.6	-0.2
Whole body water mass	1.1	6.3	14.4	-3.8	-0.7	2.0	2.4	-2.3	2.9
Leg predicted mass (right)	0.8	4.1	8.2	-2.9	-1.4	0.8	2.7	-1.7	1.9
Arm fat mass (left)	0.9	3.6	9.8	-0.0	-3.1	-2.3	2.3	-0.7	-1.0
Number of self-reported non-cancer illnesses	0.4	0.7	1.1	0.8	-0.1	-0.8	1.1	1.0	-0.9
Average weekly champagne plus white wine intake	0.4	0.5	1.1	-0.0	1.0	1.1	0.7	-0.0	-0.3
Miserableness	0.2	0.4	1.2	0.1	0.3	0.1	-0.3	-1.1	1.0
Guilty feelings	0.2	0.3	0.8	0.5	-0.9	-0.5	-0.2	0.6	-0.1
Wears glasses or contact lenses	0.1	0.1	0.3	0.6	0.1	-0.5	-0.2	0.3	-0.3
Ever taken oral contraceptive pill	0.4	0.4	0.9	0.0	0.6	0.9	0.8	0.8	-0.1
Hearing aid user	4.1	4.6	11.7	-1.2	3.4	3.0	-2.0	0.8	0.6
Mother’s age at death	0.8	1.0	2.1	1.5	0.3	-0.2	1.0	1.0	-1.3
Financial situation satisfaction	0.9	1.1	3.9	-0.6	1.3	2.0	0.1	0.5	0.3
Tinnitus: Yes, now most or all of the time	0.5	0.6	2.4	-0.1	0.0	0.9	1.6	0.4	-0.2
Commuting to job workplace: Public transport	0.6	0.8	2.7	0.0	-0.3	-0.2	1.7	1.1	-0.6
Eye problems/disorders: Glaucoma	1.0	1.2	2.9	-1.0	-0.5	-0.1	-1.7	-1.2	1.4
Medication: Blood pressure	0.3	0.6	1.3	1.1	-0.7	-0.6	-0.2	0.7	-1.1
Pain type(s) experienced in last month: Hip pain	0.3	0.4	0.7	-0.4	0.2	0.8	0.8	0.6	0.6
Supplements: Fish oil (including cod liver oil)	2.0	2.6	4.6	-1.0	1.6	1.9	-1.9	-0.3	2.1
High cholesterol (Self-reported)	0.9	1.7	3.7	1.5	-0.8	-1.2	1.1	0.8	-1.9
Medication: Bendroflumethiazide	0.1	0.1	0.4	0.1	-0.7	0.1	0.1	-0.3	-0.5
Medication: Paracetamol	1.6	2.4	6.7	-2.6	0.0	1.2	-0.5	-1.3	2.2
Medication: Lisinopril	3.8	4.9	9.8	3.1	-0.7	-1.7	1.2	2.4	-3.1
Medication: Atorvastatin	0.5	0.6	1.8	-0.6	1.3	1.1	0.0	-0.3	0.1
Illnesses of father: High blood pressure	0.1	0.1	0.3	0.3	-0.2	0.2	0.1	0.1	0.5
Alcohol drinker status: Never	0.8	0.9	4.3	0.5	-0.3	-0.1	2.1	-0.2	-0.9
Ever smoked	1.0	1.8	6.4	1.6	-0.1	-0.7	0.5	1.0	-2.5
Basal metabolic rate	0.9	5.0	10.4	-3.2	-1.5	1.1	2.6	-2.1	2.3
Leg fat percentage (left)	1.4	4.9	10.7	1.7	-3.1	-3.3	1.5	0.3	-2.0
Arm fat-free mass (left)	1.3	6.7	15.7	-4.0	-0.8	2.2	1.6	-2.6	3.1
Number of operations (self-reported)	1.3	1.9	3.6	-1.0	1.9	1.5	-1.7	-0.8	1.0
Average weekly beer plus cider intake	0.8	1.1	2.0	-1.3	0.9	1.3	-0.4	-1.4	0.4
Irritability	0.7	1.2	3.3	-0.3	1.3	0.8	-1.8	-1.1	0.6
Risk taking	1.3	1.9	3.1	-0.8	0.8	1.5	-1.8	-1.7	1.3
Ever had prostate specific antigen (PSA) test	0.1	0.1	0.2	0.3	0.4	0.1	0.1	-0.5	-0.1
Fractured/broken bones in last 5 years	2.6	3.4	6.5	-2.2	0.5	1.6	-1.5	-2.0	2.6
Age started oral contraceptive pill	0.6	0.7	1.1	0.8	-0.9	-0.8	0.8	1.1	-0.8
Diastolic blood pressure, automated reading	0.3	1.0	2.7	0.8	-0.4	-1.3	-0.9	1.7	-0.2
Ever depressed for a whole week	2.9	3.5	5.7	1.7	-0.8	-1.4	2.2	2.4	-2.3
Unable to work because of sickness or disability	1.5	1.9	5.7	0.4	-2.3	-2.4	-0.2	-0.7	-0.5
Commuting to job workplace: Cycle	1.9	2.4	5.5	-0.4	1.8	2.3	-1.5	-0.4	1.7
Myopia	1.1	1.5	4.6	1.6	1.3	0.3	-0.2	0.6	-2.1
Vascular/heart problems diagnosed by doctor	1.3	3.6	8.6	-2.0	-0.3	0.4	-1.1	-2.7	2.9
Cholesterol lowering medication	0.7	1.0	2.5	0.4	-1.5	-1.1	0.3	-0.4	-1.6
Medication: Omeprazole (e.g. Zanprol)	2.2	2.7	4.5	-1.9	0.3	1.2	-1.5	-2.1	1.9
Pain experienced in last month	0.1	0.1	0.4	0.1	0.2	0.0	-0.6	0.0	-0.4
Supplements: Calcium	0.8	0.9	2.2	-0.5	1.5	0.7	-1.3	-0.8	0.5
Basal cell carcinoma (self-reported)	0.3	0.3	0.7	-0.9	-0.8	-0.1	0.3	0.3	0.7
Heart attack/myocardial infarction (self-reported)	1.1	1.5	4.4	-1.1	1.8	2.1	0.0	-0.2	0.2
Deep venous thrombosis (DVT) (self-reported)	2.0	2.5	5.9	-2.2	-1.4	-0.2	-0.2	-2.4	1.6
Heart disease (siblings)	0.7	0.9	2.6	-0.5	-0.7	0.3	-0.9	-1.6	0.9
Alcohol drinker status: Previous	0.7	0.8	2.3	-0.9	-1.5	-0.9	-0.5	-0.1	0.8
Pack years of smoking	0.7	1.0	2.4	-0.1	-1.5	-1.6	0.8	0.5	0.5
Impedance of whole body	0.4	2.0	3.9	2.0	-1.1	-1.9	0.2	1.5	-0.8
Leg fat mass (left)	0.9	3.6	10.6	-0.1	-3.3	-2.4	2.1	-0.5	-0.8
Arm predicted mass (left)	1.2	6.0	14.3	-3.8	-0.8	2.0	1.8	-2.3	3.0