Best TWAS P=1.89e-09 · Best GWAS P=2.44e-09 conditioned to 0.171
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Brain Cerebellar Hemisphere | SAV1 | 0.19 | 0.06 | lasso | 7 | 0.02 | 1.3e-01 | -5.1 | -6.0 | 1.9e-09 | 0.89 | 0.03 | 0.80 | TRUE |
| 2 | GTEx | Cells Transformed fibroblasts | SAV1 | 0.29 | 0.12 | lasso | 8 | 0.18 | 4.0e-13 | -4.8 | -5.2 | 1.6e-07 | 0.65 | 0.42 | 0.57 | FALSE |
| 3 | GTEx | Esophagus Mucosa | SAV1 | 0.13 | 0.15 | enet | 14 | 0.15 | 5.1e-10 | -5.6 | -5.5 | 3.5e-08 | 0.87 | 0.03 | 0.97 | FALSE |
| 4 | GTEx | Muscle Skeletal | NIN | 0.10 | 0.04 | enet | 10 | 0.08 | 4.8e-08 | -4.7 | -5.4 | 7.1e-08 | 0.63 | 0.52 | 0.47 | FALSE |
| 5 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | SAV1 | 0.07 | 0.05 | enet | 6 | 0.07 | 1.1e-06 | -5.7 | -5.9 | 4.3e-09 | 0.94 | 0.01 | 0.99 | FALSE |
| 6 | The Cancer Genome Atlas | Brain Lower Grade Glioma | SAV1 | 0.07 | 0.02 | enet | 8 | 0.04 | 2.3e-05 | 3.3 | -5.7 | 1.4e-08 | 0.78 | 0.05 | 0.92 | FALSE |