Hub : Genes

NIN

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Cells Transformed fibroblasts	0.1250	0.0390	8.3e-05	0.081	NA	0.082	NA	0.098	1.1e-06	NA	1.0e-06	NA	8.7e-08
2	GTEx	Esophagus Mucosa	0.3720	0.0580	2.6e-15	0.314	NA	0.341	NA	0.336	2.0e-21	NA	1.4e-23	NA	3.5e-23
3	GTEx	Muscle Skeletal	0.0962	0.0324	1.1e-04	0.039	NA	0.077	NA	0.068	9.8e-05	NA	4.8e-08	NA	2.8e-07
4	NTR	Blood	0.0281	0.0108	4.7e-04	-0.001	0.003	0.001	0.004	0.000	6.8e-01	0.03700	9.8e-02	1.1e-02	4.8e-01
5	YFS	Blood	0.0417	0.0146	5.7e-04	0.003	0.010	0.017	0.012	0.008	2.6e-02	0.00018	1.9e-06	5.7e-05	9.0e-04

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bipolar Disorder (2018)	0.2	0.3	0.8	0.2	-0.2	-0.7	-0.9	-0.0
Bipolar Disorder or Schizophrenia	0.3	0.8	1.7	1.3	0.4	1.0	-1.0	-0.4
Depressed Affect (Nagel 2018)	0.3	0.7	1.6	0.4	-1.1	-0.1	-0.7	-1.3
Depression (Nagel 2018)	0.7	1.0	2.0	0.3	-1.0	-0.6	1.4	-1.3
Intelligence (Savage-Jansen 2018)	0.8	2.3	4.0	-1.5	1.7	-2.0	-1.6	0.2
Neuroticism (Nagel 2018)	0.5	1.1	2.5	-0.3	-0.4	-0.8	-1.4	-1.6
Schizophrenia (2018)	0.7	1.4	3.5	1.6	0.6	1.9	-0.6	-0.5
Schizophrenia vs Biploar Disorder	3.4	4.5	6.8	2.2	2.5	2.6	-1.2	1.7
Worry (Nagel 2018)	1.2	2.6	4.8	-1.8	-0.3	-2.2	-1.3	-1.8
Alzheimer’s Disease (in mother)	0.3	0.3	0.7	-0.0	-0.4	-0.4	-0.8	-0.8
Alzheimer’s Disease (in father)	1.5	1.6	4.9	0.5	2.2	0.8	-1.4	-0.7
Alzheimer’s Disease (including proxy)	0.7	1.0	4.3	0.4	0.3	-0.0	-2.1	-0.5
Crohns Disease (2017)	1.1	2.4	4.4	1.0	1.4	2.0	-2.1	-0.7
Irritable Bowel Disease (IBD)	0.5	1.2	2.6	1.3	0.7	1.6	-1.2	0.2
Ulcerative Colitis (UC)	0.1	0.2	0.6	0.7	-0.0	0.4	0.4	0.4
Major Depression (MDD)	0.4	0.5	0.9	0.3	-0.9	-0.1	0.9	0.8
Reaction Time	0.2	0.3	0.8	-0.1	0.8	0.2	-0.0	-0.9
Verbal and Numeric Reasoning (VNR)	0.7	1.7	3.9	-1.3	1.4	-2.0	-0.9	0.7
Breast Cancer	0.4	1.0	2.4	0.5	-1.2	0.5	-0.6	-1.5
Ovarian Cancer	0.4	0.5	1.4	-0.2	-0.9	-0.4	-0.1	-1.2
Prostate Cancer	1.1	1.5	3.8	-1.2	1.9	-1.1	-0.3	-0.9
Age at First Birth	0.6	0.9	2.0	-0.3	1.3	-0.8	1.4	-0.4
Bipolar Disorder (2011)	0.1	0.1	0.5	-0.1	-0.2	-0.7	0.2	0.1
Body Mass Index (BMI) (2010)	0.3	0.4	0.8	-0.9	0.8	-0.4	0.4	0.3
Coronary Artery Disease (CAD)	0.4	0.5	1.2	-0.1	0.8	1.1	0.6	-0.1
Crohns Disease (2012)	0.4	0.6	1.4	-0.3	1.2	0.6	-1.1	0.3
Mean Putamen Volume	0.6	0.7	2.0	1.4	0.6	1.2	-0.0	0.0
Fasting Glucose	0.1	0.2	0.5	0.3	0.2	0.4	-0.2	0.7
HbA1C	0.5	0.6	2.2	0.3	-1.5	-0.3	0.2	-0.6
HDL Cholesterol	1.0	1.6	2.4	1.5	-0.0	1.3	-1.4	-1.5
LDL Cholesterol	0.8	1.3	3.4	1.8	0.2	1.7	0.3	-0.1
Lupus	1.8	2.7	5.9	-2.4	-1.3	-1.1	1.5	-1.5
Neuroticism (2016)	0.6	0.9	1.4	-0.6	-1.1	-0.7	1.1	-1.2
Primary Biliary Cirrhosis	0.3	0.5	1.7	-0.4	-0.1	-0.3	-1.3	0.5
Rheumatoid Arthritis	1.2	1.7	6.1	0.5	-0.6	1.2	2.5	0.2
Schizophrenia (2014)	2.0	4.4	9.2	3.0	1.4	2.8	-1.1	1.2
Triglycerides	0.8	1.2	4.9	0.1	-1.0	0.5	2.2	0.3
Type 2 Diabetes (T2D) (2012)	0.2	0.2	0.5	-0.7	-0.7	-0.2	-0.1	0.5
Ulcerative Colitis	0.7	1.0	3.1	0.8	0.7	0.2	0.7	1.8
Blood Eosinophil Count	0.1	0.5	1.5	-1.2	0.1	0.1	-0.9	-0.3
Blood Platelet Count	0.4	4.5	14.1	2.6	0.5	3.8	1.2	0.5
Blood Red Count	0.2	2.4	7.4	2.7	-1.0	1.2	-1.5	-0.0
Blood White Count	0.2	1.3	3.7	-1.2	-0.3	-0.7	1.9	0.9
Heel T-Score	0.1	0.4	1.0	0.6	0.9	-1.0	-0.2	0.2
BMI	0.1	0.7	2.1	0.4	-0.2	1.0	0.3	1.4
Height	0.6	10.8	29.1	-4.6	-1.6	-5.4	-1.1	-0.4
Waist Hip Ratio (WHR)	0.2	1.1	2.9	-0.3	-0.9	-0.8	1.7	-1.0
Systolic Blood Pressure	1.8	9.1	18.7	3.8	3.2	4.3	0.6	1.5
Smoking Status	0.5	1.1	2.4	-1.6	-0.5	-1.1	-0.8	-1.0
Allergy or Eczema	0.6	1.6	5.9	-0.7	2.4	-0.5	-0.6	-0.9
Cardiovascular Disease	0.8	2.5	8.4	0.9	2.9	1.0	1.4	0.6
Hypothyroidism (self reported)	0.6	1.5	3.8	1.0	1.9	1.1	-0.7	0.9
Respiratory disease	0.3	0.7	2.0	0.1	1.4	-0.5	-1.0	-0.2
Type 2 Diabetes (T2D) (2018)	0.5	0.9	3.6	-0.1	0.6	0.6	0.4	1.9
Lung FEV1/FVC ratio	1.0	5.1	13.6	1.7	-0.2	2.9	-3.7	0.7
Lung FVC	0.3	1.4	3.4	-0.0	1.8	0.5	1.8	-0.1
Neuroticism	0.3	0.8	1.9	-0.6	-0.5	-1.4	-1.0	-0.8
Chronotype (morning person)	0.6	1.3	4.0	-1.0	0.3	-0.7	0.8	-2.0
Hair Pigment	0.1	3.0	6.6	2.3	0.4	2.6	-1.8	-0.0
Tanning	0.1	0.9	1.6	-1.3	-1.2	-1.1	0.0	-0.6
Hand grip strength (left)	0.3	0.8	2.0	1.1	0.2	0.2	-0.8	1.4
Number of treatments/medications taken	0.7	1.2	3.8	-0.6	1.9	-0.4	1.4	-0.0
Average weekly spirits intake	0.5	0.6	1.3	0.1	-1.2	-0.2	-1.1	-0.7
Sensitivity / hurt feelings	1.1	2.0	8.4	1.0	0.2	0.1	-2.9	-0.6
Frequency of depressed mood in last 2 weeks	0.3	0.4	1.5	0.5	-0.0	-0.3	-0.4	-1.2
Hearing difficulty/problems: Yes	0.4	0.5	1.6	1.2	-0.9	0.2	-0.3	-0.5
Relative age of first facial hair	0.6	1.2	2.9	-1.7	0.5	-1.4	0.7	0.8
Other serious medical condition/disability diagnosed by doctor	1.1	1.5	5.0	-0.9	1.1	-0.0	2.2	-0.5
Ever used hormone-replacement therapy (HRT)	0.6	0.8	2.8	-0.8	-0.3	-1.7	-0.2	0.6
Ever had hysterectomy (womb removed)	0.1	0.1	0.3	0.3	0.5	-0.2	0.4	-0.1
Systolic blood pressure, automated reading	1.0	2.9	6.8	2.1	1.6	2.6	-0.9	0.3
Eye problems/disorders: Diabetes related eye disease	0.7	0.7	1.4	-0.9	0.4	-0.5	1.0	1.2
Angina	1.0	1.2	5.6	-0.0	2.4	0.3	0.7	0.4
Medication for hormone replacement therapy	0.5	0.6	1.2	-0.8	-0.8	-0.6	-0.0	1.1
Vitamin and mineral supplements	0.4	0.5	1.1	-0.5	-0.5	-0.7	-0.7	-1.0
Supplements: Zinc	0.6	0.7	2.5	-1.6	0.0	-0.6	0.4	-0.6
Medication: Co-codamol	1.5	1.7	4.4	-2.1	0.4	-1.8	1.0	0.2
Medication: Metformin	0.4	0.6	0.8	0.8	0.3	0.8	0.9	0.9
Diabetes (father)	2.3	2.9	8.1	1.6	0.4	2.8	0.7	1.8
Diabetes (mother)	0.5	0.6	1.4	-1.2	-0.8	-0.9	0.3	0.4
Severe depression (siblings)	0.7	0.8	1.6	-0.8	-0.6	-1.0	1.3	-0.4
Pack years adult smoking proportion	0.1	0.2	0.6	0.0	0.2	0.2	-0.8	0.7
Impedance of leg (right)	0.1	0.7	2.5	-0.4	0.0	-0.8	-1.6	-0.5
Leg fat-free mass (left)	0.1	0.5	1.2	-0.8	-0.7	-0.5	0.3	1.1
Trunk fat percentage	0.5	1.9	4.1	-2.0	-0.9	-1.1	1.6	-0.9
Hand grip strength (right)	0.6	1.6	4.5	0.8	0.4	0.2	-1.7	2.1
Townsend deprivation index at recruitment	0.1	0.2	0.4	-0.6	0.7	0.0	-0.2	-0.3
Current tobacco smoking	0.1	0.2	0.8	-0.6	-0.1	-0.1	-0.1	0.9
Average weekly fortified wine intake	1.3	1.6	4.5	-0.6	-1.1	-1.4	2.1	-0.0
Maternal smoking around birth	0.2	0.2	0.8	-0.9	-0.3	-0.5	0.1	-0.4
Fed-up feelings	0.4	0.6	1.2	0.9	-0.2	1.1	-0.6	-0.9
Frequency of unenthusiasm / disinterest in last 2 weeks	0.9	1.2	2.3	1.5	0.3	0.7	0.9	-1.5
Relative age voice broke	0.6	1.0	2.2	-1.1	0.4	-1.1	-0.4	-1.5
Taking other prescription medications	0.4	0.7	1.1	-1.1	0.9	-0.6	0.6	-0.9
Age when periods started (menarche)	0.4	1.0	2.0	1.0	0.0	0.0	1.3	1.4
Bilateral oophorectomy (both ovaries removed)	0.4	0.4	1.1	-1.0	0.5	-0.4	0.6	0.4
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.7	2.2	0.2	0.5	0.3	0.9	1.5
Tinnitus: Yes, but not now, but have in the past	0.3	0.3	0.7	-0.3	0.6	-0.5	-0.1	0.8
Qualifications: CSEs or equivalent	0.7	0.9	3.9	0.1	-0.9	-0.2	-2.0	-0.2
Serious illness, injury or assault to yourself	0.3	0.4	0.7	-0.7	-0.7	-0.8	-0.3	-0.1
High blood pressure	0.8	2.3	4.6	1.5	1.0	2.2	1.9	0.4
Hayfever, allergic rhinitis or eczema	0.5	1.1	5.2	-0.2	2.3	-0.2	0.2	-0.6
Multivitamins +/- minerals	0.4	0.5	1.0	0.2	-0.3	1.0	0.8	0.8
Stomach or abdominal pain in last month	0.7	0.9	2.5	0.6	1.0	1.6	0.8	0.0
Supplements: Glucosamine	0.9	1.2	2.0	-1.4	-1.1	-1.1	0.5	1.3
Diverticular disease/diverticulitis (self-reported)	0.2	0.3	0.9	-0.6	-0.2	-0.9	-0.0	-0.1
Medication: Atenolol	0.4	0.5	1.0	0.4	-0.5	0.9	1.0	0.4
Medication: Levothyroxine sodium	0.8	1.4	6.3	0.4	2.5	0.5	0.2	-0.6
Sitting height	0.3	2.3	4.0	-0.8	-1.6	-1.4	-2.0	1.5
Chronic bronchitis/emphysema (father)	1.0	1.2	2.2	-1.0	-0.5	-1.5	-0.8	-1.4
High blood pressure (mother)	1.1	1.5	5.6	0.8	-0.7	0.8	2.4	0.5
Body mass index (BMI)	0.0	0.1	0.3	-0.2	-0.3	0.6	0.3	0.4
Impedance of leg (left)	0.2	0.8	1.4	-0.8	-0.2	-1.1	-1.2	-0.8
Leg predicted mass (left)	0.1	0.6	1.3	-0.8	-0.8	-0.5	0.4	1.1
Trunk fat mass	0.3	1.4	4.0	-2.0	-0.8	-1.1	1.0	-0.2
Waist circumference	0.3	1.2	2.2	-1.5	-1.4	-0.7	0.9	-0.4
Number of incorrect matches in round	0.2	0.4	0.8	0.8	0.2	0.6	0.1	0.9
Past tobacco smoking	0.3	0.6	1.8	1.3	-0.0	0.7	0.4	0.5
Alcohol usually taken with meals	0.3	0.5	0.8	0.9	-0.5	0.2	0.8	0.7
Nervous feelings	1.3	2.5	6.0	-1.2	-0.4	-1.5	-1.6	-2.5
Frequency of tenseness / restlessness in last 2 weeks	0.4	0.6	2.5	-0.1	0.8	-0.2	0.3	-1.6
Hearing difficulty/problems with background noise	1.3	2.0	2.9	1.5	-1.4	0.7	1.7	-1.6
Hair/balding pattern: Pattern 2	1.3	1.6	4.7	0.9	-2.2	0.6	-1.0	-1.0
Had menopause	0.6	0.8	1.2	-1.1	0.2	-1.1	-0.7	1.0
Had other major operations	0.3	0.4	1.2	-0.4	0.7	-0.4	-1.1	0.1
Forced vital capacity (FVC)	0.2	0.6	1.3	0.7	0.3	0.6	1.0	1.2
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.5	2.1	0.1	0.4	0.1	0.5	1.4
Ever unenthusiastic/disinterested for a whole week	0.5	0.6	1.0	0.9	0.8	1.0	0.5	0.7
Qualifications: None of the above	0.2	0.5	1.4	-0.6	-0.2	-0.2	-0.8	-1.2
Financial difficulties in last 2 years	0.2	0.3	0.8	-0.3	0.4	-0.2	0.6	-0.9
Mouth/teeth dental problems	0.2	0.3	0.5	-0.7	-0.2	-0.7	0.7	0.4
Heart attack	2.7	3.5	13.3	-0.6	3.6	-0.3	-1.8	0.7
Allergy	0.6	1.4	3.2	0.5	-1.8	0.8	-0.9	1.4
Pain all over the body in last month	1.7	1.9	4.7	-1.7	-0.5	-2.2	1.0	-0.6
Diabetes (self-reported)	0.4	0.6	1.6	0.4	0.8	0.8	0.5	1.3
Hayfever/allergic rhinitis (self-reported)	0.8	1.0	4.8	0.2	2.2	-0.3	-0.2	-0.6
Medication: Ramipril	1.7	2.2	7.3	0.8	2.7	1.2	1.3	0.3
Medication: Simvastatin	0.9	1.4	4.9	-0.9	0.1	-1.1	2.2	-0.1
Fluid intelligence score	0.3	0.7	2.1	-0.1	1.0	-0.4	0.2	1.5
Illnesses of siblings	1.2	1.7	7.7	-0.5	0.0	-0.5	2.8	-0.4
Neuroticism score	0.5	1.0	2.5	-0.1	-0.7	-0.9	-1.6	-1.2
Weight	0.1	0.7	1.7	-1.3	-0.7	-0.9	-0.1	0.6
Impedance of arm (right)	0.9	4.4	13.6	-0.6	-0.3	-1.0	3.7	-2.7
Arm fat percentage (right)	0.3	1.1	4.3	-0.6	-0.4	0.2	2.1	-0.9
Trunk fat-free mass	0.4	2.2	6.0	-1.2	-0.2	-1.3	-1.4	2.5
Hip circumference	0.2	0.8	1.8	-1.3	-1.0	-0.6	0.7	0.6
Time employed in main current job	1.0	1.1	5.4	0.0	-2.3	-0.2	0.0	-0.5
Alcohol intake versus 10 years previously	1.6	2.5	6.8	-2.6	-1.6	-1.7	0.2	-0.0
Father’s age at death	0.2	0.3	0.6	-0.5	0.3	-0.8	0.6	0.3
Worrier / anxious feelings	0.4	0.7	1.6	-0.6	0.6	-1.1	-1.3	-0.2
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.5	1.1	-0.8	-0.0	-0.7	0.6	-1.0
Falls in the last year	0.9	1.2	2.5	1.0	0.5	1.2	-0.7	-1.6
Hair/balding pattern: Pattern 3	0.7	1.1	2.8	0.4	1.7	1.2	-0.7	0.6
Number of live births	0.6	0.8	3.1	-0.2	0.2	-0.9	-1.8	0.2
Forced expiratory volume in 1-second (FEV1)	0.3	1.1	1.9	1.4	0.2	1.4	0.1	1.3
Pulse rate	0.5	0.8	1.8	1.4	-0.4	0.8	-1.0	-0.6
Happiness	0.5	0.6	1.6	0.7	1.3	0.6	-0.5	-0.0
Noisy workplace	0.6	0.8	3.1	-0.4	-0.6	-0.6	-0.1	-1.8
Qualifications: A levels/AS levels or equivalent	0.3	0.6	1.4	0.3	1.2	-1.0	0.5	-0.5
Serious illness, injury or assault of a close relative in last 2 years	2.2	2.6	5.1	-2.2	-0.2	-2.3	1.7	-0.3
Mouth/teeth dental problems: Dentures	0.5	0.9	1.3	-1.0	-1.1	-0.5	-0.7	1.2
Asthma	0.5	0.9	1.9	0.7	1.2	0.1	1.4	-0.9
Medication: Ibuprofen (e.g. Nurofen)	0.3	0.3	0.4	0.5	-0.6	0.6	0.6	-0.6
Medication: Cholesterol lowering	0.7	1.1	4.0	-0.6	0.9	-0.7	2.0	-0.1
Depression (self-reported)	1.4	1.6	3.6	1.9	1.0	1.5	-1.2	-0.1
Medication: Lansoprazole	2.5	2.8	6.2	-2.4	-0.4	-1.3	2.5	-0.6
Prospective memory result	0.7	0.8	2.2	-1.1	0.1	-1.5	-0.8	-0.2
Lung cancer (father)	1.6	1.8	7.3	-1.0	-0.5	-0.6	-2.7	-0.5
Illnesses of mother	1.5	1.8	5.2	0.3	1.9	0.5	-2.3	-0.0
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.4	0.7	0.9	-0.6	0.7	-0.0	0.7
Pulse wave Arterial Stiffness index	1.1	1.2	3.7	-1.9	0.2	-1.2	0.8	-0.6
Impedance of arm (left)	0.8	3.8	11.2	-0.5	-0.1	-0.6	3.3	-2.7
Arm fat mass (right)	0.2	0.6	1.1	-1.0	-0.9	-0.4	1.1	-0.1
Trunk predicted mass	0.4	2.2	5.8	-1.3	-0.3	-1.4	-1.3	2.4
Standing height	0.5	4.5	12.2	-2.7	-1.4	-3.5	-0.8	0.4
Length of working week for main job	0.8	0.9	2.8	0.7	0.0	1.1	-1.7	-0.6
Exposure to tobacco smoke at home	0.7	0.8	2.3	-0.9	-0.8	-0.0	-1.5	-0.7
Breastfed as a baby	1.0	1.2	2.7	0.6	-1.4	0.6	1.7	0.9
Tense / ‘highly strung’	0.3	0.6	1.0	-0.6	-0.3	-1.0	-0.7	-1.0
Seen doctor (GP) for nerves, anxiety, tension or depression	0.4	0.6	2.0	-0.3	0.3	-0.7	-0.4	-1.4
Hair/balding pattern: Pattern 4	0.3	0.7	1.7	0.3	-0.9	0.5	-1.3	0.9
Birth weight of first child	0.4	0.7	1.7	1.3	-0.8	0.8	0.7	0.3
Peak expiratory flow (PEF)	0.6	1.4	4.0	1.6	0.3	2.0	0.1	0.8
Pulse wave reflection index	1.1	1.3	3.7	-0.7	-0.6	-0.2	1.4	1.9
Ever highly irritable/argumentative for 2 days	0.5	0.6	2.4	-0.5	0.3	-0.2	1.5	0.5
Loud music exposure frequency	0.8	0.9	2.2	0.5	-1.5	0.5	1.3	0.1
Qualifications: O levels/GCSEs or equivalent	0.6	1.0	1.5	1.2	1.1	1.0	0.4	0.9
Mouth/teeth dental problems: Bleeding gums	1.5	2.0	4.1	1.4	1.2	1.4	-2.0	0.1
Blood clot in the leg (DVT)	2.3	2.9	5.6	-1.6	-0.5	-2.2	2.4	-1.1
Medication: Paracetamol	0.3	0.6	1.0	-0.9	-1.0	0.5	0.7	-0.5
Headache pain in last month	1.0	1.7	5.6	-0.1	-0.7	-0.5	2.4	-1.5
Medication for cholesterol, blood pressure or diabetes	0.6	1.0	4.3	-0.1	-0.5	0.0	-2.1	-0.4
Glaucoma (self-reported)	0.9	1.1	3.2	-0.8	0.1	-0.7	-1.8	1.0
Gout (self-reported)	0.9	1.2	2.1	1.5	1.1	1.2	-0.9	-0.6
Hypothyroidism/myxoedema (self-reported)	0.3	0.5	2.0	-0.2	1.4	0.3	-0.2	0.6
Medication: Amlodipine	1.0	1.4	4.0	1.2	1.0	2.0	0.6	-0.6
Medication: Ventolin 100micrograms inhaler	1.7	2.2	5.3	-1.0	2.3	-1.0	-0.1	-1.9
Birth weight	0.4	0.9	1.7	-0.2	0.5	-1.3	1.0	-1.3
Chronic bronchitis/emphysema (mother)	0.1	0.1	0.5	-0.0	-0.3	0.0	0.2	-0.7
High blood pressure (siblings)	1.7	2.5	5.4	1.8	0.4	1.3	-2.3	1.3
Forced vital capacity (FVC), Best measure	0.1	0.4	1.0	0.3	-0.4	-0.2	1.0	0.8
Body fat percentage	0.1	0.5	1.3	-1.1	-0.2	-0.1	0.9	-0.5
Leg fat percentage (right)	0.1	0.4	1.2	-0.4	0.6	0.3	-1.1	0.5
Arm fat-free mass (right)	0.5	2.4	4.8	-1.4	-0.5	-1.2	-1.9	2.2
Exposure to tobacco smoke outside home	0.7	0.9	1.6	1.0	0.6	0.8	-1.0	-1.3
Comparative body size at age 10	0.2	0.6	1.8	-0.7	0.4	-0.0	1.3	0.6
Number of full brothers	0.4	0.5	1.0	-0.8	-0.6	-1.0	0.2	-0.8
Worry too long after embarrassment	0.8	1.3	2.3	1.1	1.5	0.7	-1.4	0.8
Seen a psychiatrist for nerves, anxiety, tension or depression	1.2	1.6	6.1	1.1	0.1	0.6	-2.5	0.4
Wheeze or whistling in the chest in last year	0.3	0.5	1.6	1.3	-0.5	0.4	-0.1	-0.8
Number of children fathered	0.2	0.2	0.5	0.2	0.7	0.4	-0.4	0.2
Reason for reducing amount of alcohol drunk: Health precaution	0.4	0.4	0.8	0.3	0.9	0.9	0.5	-0.5
Age at first live birth	1.0	1.8	4.8	-0.7	0.1	-0.6	2.2	-1.8
Pulse wave peak to peak time	0.8	1.0	3.0	1.7	-0.5	1.0	-0.5	0.7
Health satisfaction	0.3	0.4	1.5	-0.5	0.3	-0.4	-1.2	-0.2
Shortness of breath walking on level ground	0.2	0.2	0.5	-0.4	0.3	-0.6	-0.1	-0.7
Qualifications: College or University degree	0.2	0.6	1.6	-0.6	0.9	-1.3	0.3	-0.2
Eye problems/disorders: None of the above	0.5	0.6	0.9	0.9	0.9	-0.0	-0.9	-0.8
Mouth/teeth dental problems: Loose teeth	1.5	1.8	4.0	1.8	1.1	2.0	0.1	0.8
Emphysema/chronic bronchitis	0.4	0.5	1.5	0.1	-1.2	-0.3	0.3	-0.9
Medication for pain relief, constipation, heartburn	0.5	0.8	3.6	0.5	0.5	-0.1	-1.9	0.1
Neck or shoulder pain in last month	1.0	1.4	6.1	0.2	-0.9	0.4	2.5	0.1
Medication: Blood pressure	0.7	1.2	4.3	0.2	0.6	0.6	2.1	1.0
Angina (self-reported)	0.9	1.2	4.9	-0.1	2.2	0.1	0.9	0.4
Migraine (self-reported)	0.4	0.4	0.8	-0.8	-0.6	-0.4	0.9	0.5
Medication: Ibuprofen	0.4	0.4	0.6	0.3	-0.7	0.7	0.8	0.6
Medication: Allopurinol	0.4	0.5	1.3	1.1	-0.2	0.9	-0.4	-0.6
Medication: Omeprazole	0.5	0.6	2.0	0.4	0.6	0.4	-0.3	1.4
Medication: Seretide 50 evohaler	1.3	1.5	5.2	-0.3	0.7	0.0	2.3	1.2
Mean time to correctly identify matches	0.4	0.8	3.7	-0.3	1.9	0.4	-0.1	-0.4
Heart disease (mother)	0.8	1.0	3.0	-0.2	-1.2	0.1	1.7	0.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.5	0.5	1.1	0.9	0.1	1.1	-0.2	0.8
Whole body fat mass	0.1	0.6	2.1	-1.4	-0.5	-0.6	0.5	-0.0
Leg fat mass (right)	0.1	0.3	0.5	-0.7	-0.1	0.1	-0.6	0.7
Arm predicted mass (right)	0.6	2.9	6.1	-1.4	-0.3	-1.2	-2.3	2.5
Pulse rate, automated reading	0.3	0.8	4.0	-0.0	0.1	-0.3	-2.0	0.1
Alcohol intake frequency.	0.6	1.5	3.5	0.5	-1.8	0.4	1.9	0.6
Comparative height size at age 10	0.2	1.2	2.9	-1.7	0.5	-1.6	0.2	-0.3
Number of full sisters	1.6	2.0	5.2	-1.5	-2.3	-0.9	1.2	0.4
Suffer from ‘nerves’	0.6	1.0	2.9	0.5	0.5	0.0	-1.7	-1.3
Overall health rating	0.2	0.4	1.3	-0.8	0.4	0.2	-0.2	-1.1
Chest pain or discomfort	0.4	0.5	1.7	-0.0	-1.0	0.2	1.3	-0.1
Had major operations	0.2	0.2	0.8	-0.2	0.1	0.2	0.9	-0.5
Age at last live birth	0.7	1.1	4.4	0.1	0.8	-0.1	-0.4	-2.1
Family relationship satisfaction	0.4	0.5	1.3	0.1	0.3	-1.1	-0.4	-1.0
Leg pain on walking	1.0	1.2	2.9	0.1	1.4	-0.4	-1.7	-1.0
Qualifications: NVQ or HND or HNC or equivalent	0.9	1.0	3.7	0.3	-1.9	-0.1	0.3	1.1
Commuting to job workplace: Car/motor vehicle	1.0	1.1	2.0	1.4	-0.2	1.2	-1.4	0.2
Illness, injury, bereavement, stress in last 2 years	0.8	1.0	2.3	0.3	1.2	0.9	-0.6	1.5
Medication: Aspirin	1.2	1.5	6.1	0.4	0.4	0.4	2.5	1.1
Supplements: Vitamin C	1.1	1.3	3.8	-1.0	1.3	-2.0	0.0	-0.1
Knee pain experienced in last month	0.7	1.1	3.2	0.8	0.6	1.8	-0.9	-0.6
Hypertension (Self-reported)	0.8	2.3	4.4	1.4	0.8	2.1	1.9	0.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.1	0.1	0.4	-0.3	-0.3	0.1	-0.7	0.2
Illnesses of father: Heart disease	0.3	0.4	1.1	0.6	-0.4	-0.3	1.1	0.1
Illnesses of siblings: Diabetes	0.7	0.9	3.1	0.3	0.1	0.8	-1.8	0.7
Smoking status: Previous	1.0	1.4	3.8	-1.9	0.4	-1.6	-0.1	-0.7
Forced expiratory volume in 1-second (FEV1), predicted	0.1	0.3	0.9	0.9	-0.4	0.4	-0.1	-0.3
Whole body fat-free mass	0.3	1.5	3.8	-1.2	-0.5	-1.2	-0.8	1.9
Leg fat-free mass (right)	0.1	0.7	0.9	-0.9	-1.0	-0.6	0.5	0.9
Arm fat percentage (left)	0.3	1.1	4.2	-0.5	0.1	0.4	2.1	-0.8
Average weekly red wine intake	0.8	1.3	3.2	0.3	1.4	0.1	-1.0	1.8
Handedness (chirality/laterality): Left-handed	2.0	2.4	4.0	2.0	1.3	1.8	1.7	0.3
Mood swings	1.0	1.8	3.3	1.7	-0.6	0.8	-1.4	-1.8
Loneliness, isolation	0.8	1.1	3.8	-0.2	0.4	0.7	-1.0	-1.9
Long-standing illness, disability or infirmity	0.5	0.7	1.6	-0.1	1.1	0.6	1.2	-0.6
Ever had bowel cancer screening	1.1	1.3	5.0	0.8	0.2	0.9	0.5	-2.2
Diabetes diagnosed by doctor	0.2	0.4	1.0	0.5	0.2	0.7	0.0	1.0
Ever had stillbirth, spontaneous miscarriage or termination	0.6	0.7	1.6	-0.0	0.3	1.3	1.1	-0.8
Friendships satisfaction	0.2	0.3	0.8	-0.1	0.1	-0.7	-0.9	-0.4
Qualifications: nursing, teaching	0.3	0.5	1.7	0.3	0.9	-0.1	-1.3	-0.1
Commuting to job workplace: Walk	0.9	0.9	2.4	0.5	0.8	0.6	1.0	1.5
Eye problems/disorders: Cataract	0.4	0.5	1.2	-0.8	-0.6	-0.5	1.1	0.4
Mouth/teeth dental problems: Mouth ulcers	0.2	0.3	0.6	-0.1	-0.2	-0.7	0.7	-0.8
Medication for cholesterol	0.1	0.1	0.2	-0.1	-0.2	-0.1	-0.5	-0.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	2.1	2.5	5.8	-1.8	-1.1	-2.4	-1.3	-0.5
Back pain experienced in last month	0.5	0.8	1.6	0.2	1.3	0.7	1.0	-0.9
Mineral and other dietary supplements	1.0	1.3	4.6	0.3	2.1	0.5	-0.1	-1.3
Breast cancer (self-reported)	0.7	0.9	1.8	0.5	-1.2	0.2	1.3	-0.9
Asthma (self-reported)	0.4	0.8	1.2	1.0	1.1	0.3	0.9	-1.1
Osteoporosis (self-reported)	1.3	1.6	3.3	1.6	-0.1	1.8	-1.4	0.0
Osteoarthritis (self-reported)	0.2	0.2	0.5	-0.6	0.1	-0.0	-0.7	-0.5
Medication: Aspirin	1.3	1.7	6.6	0.0	0.5	-0.1	2.6	1.2
Medication: Gliclazide	0.4	0.4	0.8	0.9	0.1	0.9	-0.3	0.5
Illnesses of father: None of the above (group 1)	1.4	1.7	3.3	-1.3	-1.2	-1.4	-1.8	-0.3
Smoking status: Current	0.2	0.3	1.2	-0.5	-0.4	-0.0	-0.2	1.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.6	1.3	3.1	1.4	-0.6	1.8	0.3	1.0
Whole body water mass	0.2	1.4	3.6	-1.2	-0.5	-1.1	-0.7	1.9
Leg predicted mass (right)	0.1	0.7	1.0	-0.9	-1.0	-0.7	0.5	1.0
Arm fat mass (left)	0.1	0.5	1.3	-0.9	-0.7	-0.2	1.1	-0.0
Number of self-reported non-cancer illnesses	1.0	1.7	8.3	-0.0	2.9	-0.0	0.3	-0.4
Average weekly champagne plus white wine intake	0.3	0.5	1.1	0.5	-0.9	-0.3	1.0	0.3
Miserableness	0.3	0.6	1.1	0.9	0.4	-0.2	-0.8	-1.0
Guilty feelings	0.4	0.6	1.7	-0.2	-0.1	-0.5	-1.3	-1.0
Wears glasses or contact lenses	0.6	0.7	1.6	0.6	1.1	0.7	1.3	-0.1
Ever taken oral contraceptive pill	1.4	1.5	3.7	1.2	1.9	1.2	-0.9	0.4
Hearing aid user	0.2	0.2	0.5	-0.6	0.0	-0.4	-0.7	-0.1
Mother’s age at death	1.6	1.9	5.0	-2.2	-0.7	-1.5	1.3	-0.5
Financial situation satisfaction	0.4	0.5	1.8	-0.5	1.3	-0.1	-0.5	-0.6
Tinnitus: Yes, now most or all of the time	0.3	0.3	1.6	-0.1	0.2	-0.1	0.1	-1.2
Commuting to job workplace: Public transport	0.2	0.2	0.5	-0.2	0.1	0.7	0.7	-0.3
Eye problems/disorders: Glaucoma	1.4	1.7	3.3	-1.8	0.3	-1.4	-1.2	1.3
Medication: Blood pressure	1.1	2.2	4.5	1.8	1.3	2.1	0.3	-1.1
Pain type(s) experienced in last month: Hip pain	0.4	0.5	1.6	-0.7	1.2	0.4	-0.0	0.4
Supplements: Fish oil (including cod liver oil)	0.9	1.2	4.8	-0.4	-2.2	-0.8	0.1	0.6
High cholesterol (Self-reported)	0.3	0.6	1.2	0.3	1.0	0.2	1.1	0.7
Medication: Bendroflumethiazide	0.3	0.4	1.2	-0.2	-0.9	0.1	1.1	-0.0
Medication: Paracetamol	0.2	0.2	0.7	-0.8	-0.2	0.1	0.0	-0.7
Medication: Lisinopril	0.2	0.3	0.6	0.6	0.2	0.1	-0.8	0.7
Medication: Atorvastatin	1.4	1.8	2.9	1.7	1.7	1.3	0.5	1.1
Illnesses of father: High blood pressure	1.3	1.7	2.5	1.3	1.0	1.4	1.6	1.0
Alcohol drinker status: Never	1.4	1.7	5.2	0.9	0.9	1.1	2.3	0.2
Ever smoked	0.1	0.2	0.4	-0.7	-0.5	0.0	-0.1	-0.5
Basal metabolic rate	0.2	1.3	3.0	-1.2	-0.7	-1.1	-0.6	1.7
Leg fat percentage (left)	0.1	0.3	1.0	-0.7	0.5	0.1	-1.0	0.2
Arm fat-free mass (left)	0.5	2.4	4.1	-1.6	-0.7	-1.5	-1.6	2.0
Number of operations (self-reported)	0.8	1.1	4.2	-0.6	2.0	-0.2	-0.9	0.5
Average weekly beer plus cider intake	0.2	0.2	0.4	-0.7	0.3	-0.4	-0.7	0.0
Irritability	0.6	1.1	5.1	-0.3	-2.2	0.0	0.3	-0.3
Risk taking	0.3	0.4	0.6	0.4	-0.8	0.8	0.5	-0.7
Ever had prostate specific antigen (PSA) test	0.5	0.6	1.8	0.4	1.3	0.4	-0.4	-0.9
Fractured/broken bones in last 5 years	0.4	0.6	1.6	1.3	0.2	1.0	-0.3	-0.3
Age started oral contraceptive pill	0.5	0.7	2.2	-1.1	-0.1	-1.5	-0.0	-0.0
Diastolic blood pressure, automated reading	0.7	2.0	4.3	1.7	-0.2	2.1	-1.7	-0.4
Ever depressed for a whole week	1.3	1.7	2.4	1.5	0.3	1.4	1.6	1.2
Unable to work because of sickness or disability	1.6	2.0	4.1	-1.5	1.4	-2.0	-0.3	1.4
Commuting to job workplace: Cycle	0.8	0.9	2.1	0.2	-1.4	-1.3	-0.4	-0.8
Myopia	1.6	2.3	5.5	2.3	0.0	2.4	0.8	0.1
Vascular/heart problems diagnosed by doctor	0.7	2.0	3.8	-1.2	-1.4	-1.9	-1.5	-0.5
Cholesterol lowering medication	1.0	1.5	5.2	-0.3	-0.5	-0.7	2.3	1.1
Medication: Omeprazole (e.g. Zanprol)	0.3	0.4	1.1	-0.1	1.1	0.2	-0.3	0.7
Pain experienced in last month	0.2	0.4	1.7	0.3	0.2	-0.4	-1.3	-0.3
Supplements: Calcium	0.6	0.6	1.5	-1.0	-0.6	-0.5	1.2	-0.2
Basal cell carcinoma (self-reported)	0.8	1.0	2.6	-1.6	0.5	-0.6	1.3	0.2
Heart attack/myocardial infarction (self-reported)	2.8	3.6	14.1	-0.5	3.8	-0.2	-1.8	0.7
Deep venous thrombosis (DVT) (self-reported)	1.8	2.3	4.7	-1.4	-0.4	-2.2	2.0	-1.0
Heart disease (siblings)	0.3	0.4	0.9	-0.4	-0.5	-0.2	0.9	-0.8
Alcohol drinker status: Previous	1.7	2.0	6.3	-0.0	-1.3	-0.9	2.5	1.1
Pack years of smoking	0.2	0.3	1.1	0.2	0.3	0.3	-1.0	0.3
Impedance of whole body	0.4	1.8	4.5	-0.7	-0.4	-0.9	1.7	-2.1
Leg fat mass (left)	0.1	0.3	0.7	-0.9	-0.0	-0.1	-0.6	0.5
Arm predicted mass (left)	0.5	2.5	4.1	-1.5	-0.8	-1.4	-1.8	2.0